Latest Utrophin Stories

2012-12-10 12:41:23

Approximately 250,000 people in the United States suffer from muscular dystrophy, which occurs when damaged muscle tissue is replaced with fibrous, bony or fatty tissue and loses function. Three years ago, University of Missouri scientists found a molecular compound that is vital to curing the disease, but they didn't know how to make the compound bind to the muscle cells. In a new study, published in the Proceedings of the National Academies of Science, MU School of Medicine scientists Yi...

2011-03-16 08:17:01

(Ivanhoe Newswire) "“ University of Iowa researchers have identified a new gene mutation that causes muscular dystrophy. In addition, by engineering the human gene mutation into a mouse, the researchers, have created a new mouse model that could help screen potential drugs to treat this type of muscular dystrophy. Normal dystroglycan, a protein that is abnormal in a group of congenital muscular dystrophies, is extensively modified with added sugar chains. This modification allows...

2010-12-27 20:41:24

A novel potential therapy based on a natural human protein significantly slows muscle damage and improves function in mice who have the same genetic mutation as boys with the most common form of muscular dystrophy, according to a paper published online Dec. 27 in the Proceedings of the National Academy of Sciences. Duchenne Muscular Dystrophy is a fatal genetic mutation in about one of every 3,500 boys. They are unable to produce a protein called dystrophin that keeps muscles strong. By eight...

2010-08-02 15:00:00

NOVATO, Calif., Aug. 2 /PRNewswire-FirstCall/ -- BioMarin Pharmaceutical Inc. (Nasdaq: BMRN) announced today that it has completed the Phase 1 clinical study of BMN 195, a small molecule utrophin up-regulator, for the treatment of Duchenne muscular dystrophy (DMD). The Phase 1 clinical trial was a single-center, double-blind, placebo-controlled, single-dose escalation study followed by a multiple-dose escalation study in healthy volunteers. The administration of up to 400 mg/kg did not...

Word of the Day
  • A landsman who is making his first voyage at sea; a novice who enters naval service from rural life.
According to the OED, a grass-comber is also 'a sailor's term for one who has been a farm-labourer.'