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Latest valproic acid Stories

2009-11-18 14:39:05

Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure. There have been several protocols available for hepatic fate specification from ES cells, however, most of the protocols currently used result in low yield or purity of functional hepatocytes. Valproic acid (VPA), a histone deacetylase inhibitor, has been demonstrated to...

2009-11-09 07:00:00

REHOVOT, Israel, November 9 /PRNewswire-FirstCall/ -- D-Pharm Ltd. (TASE: DPRM) announced today that it has entered into a licensing, co-development and supply agreement with Wanbang Biopharmaceuticals Ltd. for commercialization of DP-b99 in the People's Republic of China. DP-b99 is a novel drug discovered and developed by D-Pharm for treatment of patients with acute ischemic stroke. DP-b99, designated as an Investigational New Drug (IND) in the US, is currently in a Phase III...

2009-10-14 12:22:06

Pregnant women are advised to take vitamin supplements containing folic acid as part of their routine pre-natal care. Now, a new study warns that taking medications that reduce or block the actions of folic acid during the first trimester of pregnancy increase the risk that the growing baby will develop abnormalities. The large collaborative cohort study was conducted by researchers at Ben-Gurion University of the Negev. This conclusion just published in the British Journal of Clinical...

2009-10-14 11:59:42

Medications that block folic acid are associated with increased abnormalities Using medication that reduces or blocks the actions of folic acid during the first trimester of pregnancy (weeks 1-12), increases the risk that the growing baby will develop abnormalities. This conclusion was reached by a team of Epidemiologists, Paediatricians, Clinical Pharmacologists, Obstetricians and Gynecologists who examined birth and abortion data collected in Israel between 1998 and 2007. The study drew...

2009-08-17 07:00:00

REHOVOT, Israel, August 17 /PRNewswire/ -- D-Pharm announced today the completion of a financial round, which yielded NIS 85 million (approximately $23M USD) to fund the Company's late stage clinical stroke program. The financial round combined a rights offering of NIS 57 million and an Initial Public Offering (IPO) of NIS 28 million. The IPO was oversubscribed and the unit price was set at 133 NIS, 13% higher than the minimum price. The company's pre-money valuation was NIS 120 million....

2009-08-03 19:39:32

Scientists at Leeds have prevented epilepsy caused by a gene defect from being passed on to mice offspring "“ an achievement which may herald new therapies for people suffering from the condition.The study is published today in the US journal Proceedings of the National Academy of Sciences (PNAS). It offers, for the first time, irrefutable proof that a faulty version of a gene known as Atp1a3 is responsible for causing epileptic seizures in mice.Says lead researcher Dr Steve Clapcote,...

2009-07-21 18:40:11

Interim results of a study being conducted by scientists at the University of Liverpool suggest that children aged three years and younger, who are born to women taking the anti-epileptic drug sodium valproate whilst pregnant, are likely to have an IQ of six to nine points lower than average.The research, in collaboration with Emory University in the US and the Central Manchester University Hospitals NHS Foundation Trust, tested more than 300 three-year-olds in the UK and US, whose mothers...

2009-06-30 07:00:00

SOUTH SAN FRANCISCO, Calif., June 30 /PRNewswire/ -- Hyperion Therapeutics, a privately held specialty pharmaceutical company focused on the development of therapies that address critical unmet needs in the areas of gastroenterology and hepatology, today announced it has closed a $60 million Series C financing. New investors Bay City Capital and Panorama Capital co-led the financing. Series A and B investors Highland Capital Partners, NEA, and Sofinnova Ventures also participated. (Logo:...

2009-06-12 09:28:50

Three female mice have been cloned until now. The first mouse was born on 12 May, the second is now 10 days old and the third is only two days old. Scientists are studying how to improve the efficiency of the cloning process Universitat Autònoma de Barcelona (UAB) researchers are the first to have cloned mice in Spain. Cloe, Cleo and Clona are three female brown-coloured mice and were born respectively on 12 May, 3 June and 10 June. By means of nuclear transfer techniques,...

2009-06-02 07:00:00

- Company preparing to initiate phase II trial in hepatic encephalopathy - SOUTH SAN FRANCISCO, Calif., June 2 /PRNewswire/ -- Hyperion Therapeutics, Inc. today announced top-line results from a phase I study of HPN-100 in patients with liver cirrhosis. The data were presented as part of the 2009 Digestive Disease Week meeting. The abstract is titled "Pharmacokinetic (PK) and Safety Analyses of a Novel Ammonia-Reducing Agent in Healthy Adults and Patients with Cirrhosis." (Logo:...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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