Latest Vascular endothelial growth factor Stories

2013-06-03 10:48:37

Results of a randomized phase III clinical trial conducted by the Radiation Therapy Oncology Group (RTOG) determined that adding bevacizumab to initial treatment for glioblastoma (GBM) did not improve patient overall survival or progression-free survival. Results were reported June 2 during the plenary session of the American Society of Clinical Oncology 2013 Annual Meeting. GBM is the most common primary malignant brain tumor in adults and, despite treatment advances in recent years, the...

2013-06-03 10:45:11

The angiogenesis inhibitor bevacizumab (Avastin) failed to increase overall survival (OS) or statistically significant progression-free survival (PFS) for glioblastoma patients in the frontline setting, according to research led by researchers at The University of Texas MD Anderson Cancer Center. The study was presented today on the plenary session of the American Society of Clinical Oncology 2013 Annual Meeting by Mark Gilbert, M.D., professor in MD Anderson's Department of...

2013-06-03 10:43:06

Gene panel may help personalize therapy for aggressive brain tumors A new test may help identify newly diagnosed glioblastoma patients more likely to benefit from bevacizumab (Avastin®), according to new research from The University of Texas MD Anderson Cancer Center. The results of the study were presented today at the annual meeting of the American Society of Clinical Oncology. This study is associated with RTOG 0825, a large multi-center Phase III trial that evaluated the...

2013-05-17 10:38:40

Findings suggest VEGF inhibition via TGF-B1 may be beneficial The most common cause of failure after glaucoma surgery is scarring at the surgical site, so researchers are actively looking for ways to minimize or prevent scar formation. Previous work had suggested that vascular endothelial growth factor (VEGF) activates fibrosis, whereas VEGF inhibition results in reduced scar formation and better surgical results. In a series of studies using a rabbit model of glaucoma surgery,...

2013-05-14 13:20:22

Researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center report that cancers physically alter cells in the lymphatic system — a network of vessels that transports and stores immune cells throughout the body — to promote the spread of disease, a process called metastasis. The findings are published in this week's online Early Edition of the Proceedings of the National Academy of Sciences. Roughly 90 percent of all cancer...

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