Quantcast
Last updated on April 20, 2014 at 21:20 EDT

Latest Viral neuraminidase Stories

Scientists Develop Flu Drug Effective Against Drug-Resistant Virus
2013-02-23 09:29:00

Lee Rannals for redOrbit.com — Your Universe Online Scientists writing in the journal Science say they have found a new class of influenza drug is effective against drug-resistant strains of the flu virus. University of British Columbia (UBC) researchers published details about the development of a new drug candidate that is capable of preventing flu virus from spreading from one cell to the next. So far, the drug has tested successfully in mice trials, using lethal strains of the...

2012-08-04 01:12:36

Structural analysis opens the way to new anti-influenza drugs Researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have determined the detailed 3-dimensional structure of part of the flu virus' RNA polymerase, an enzyme that is crucial for influenza virus replication. This important finding is published today in PLoS Pathogens. The research was done on the 2009 pandemic influenza strain but it will help scientists to design innovative drugs against all the...

2012-01-18 12:58:11

Incomplete availability of data has hampered a thorough assessment of the evidence for using the anti-influenza drug oseltamivir, a Cochrane Review has found. However, after piecing together information from over 16,000 pages of clinical trial data and documents used in the process of licensing oseltamivir (Tamiflu) by national authorities, a team of researchers has raised critical questions about how well the drug works and about its reported safety profile. The new analysis shows...

2011-07-12 22:24:20

Findings could aid development of drugs exploiting flu protein "Ëœpockets' UC Irvine researchers have found a new approach to the creation of customized therapies for virulent flu strains that resist current antiviral drugs. Using powerful computer simulations, UCI's Rommie Amaro and Robin Bush created a method to predict how pocket structures on the surface of influenza proteins promoting viral replication can be identified as these proteins evolve, allowing for possible...

2010-11-04 08:24:30

(Ivanhoe Newswire) -- In adults with seasonal influenza A virus infection, the combination of the drugs oseltamivir (tamiflu) and zanamivir (relenza) is less effective than oseltamivir monotherapy and not significantly more effective than zanamivir monotherapy. In the past few years oseltamivir and zanamivir have been key drugs for limiting the impact of seasonal influenza both in individuals (by reducing morbidity and mortality) and collectively (by slowing the virus' spread to buy time for...

2010-11-04 01:05:46

In adults with seasonal influenza A virus infection, the combination of the drugs oseltamivir (tamiflu) and zanamivir (relenza) is less effective than oseltamivir monotherapy and not significantly more effective than zanamivir monotherapy. This key finding comes from a randomized, placebo-controlled trial"” in adults presenting with influenza symptoms at general practices throughout France during the seasonal influenza epidemic in 2008-2009"” carried out by Catherine Leport from...

2009-10-26 08:00:00

SAN DIEGO, Oct. 26 /PRNewswire/ -- Inhibikase Therapeutics, a specialty pharmaceutical company based in Atlanta, Georgia, will discuss simultaneous antiviral and antibacterial activity from small molecule agents at the 2009 BIOCOM Investor Conference. Employing a host-factor targeted approach, Inhibikase will illustrate the utility of IkT-001 and IkT-041 to treat multiple infectious diseases in humans. The Company's flu program has identified a compound, IkT-041, comparable in activity...

2009-08-21 14:42:51

The World Health Organization in Geneva, Switzerland, has issued guidelines for the use of anti-virals to combat swine flu, officials said. An international panel of experts who reviewed studies on the safety and effectiveness of anti-virials said the pandemic virus is susceptible to both oseltamivir and zanamivi, known as neuraminidase inhibitors. However, the virus is resistant to a second class of antivirals -- the M2 inhibitors. Worldwide, most patients infected with the H1N1 virus...

cb40929ec082a8345f55b81eeb154a261
2009-05-21 10:13:57

U.S. scientists say they are creating a new drug compound to combat the influenza virus, targeting the illness on two fronts. Researchers at the Rensselaer Polytechnic Institute said the world has been fortunate with the H1N1 swine flu virus in that it, so far, responds to treatment with available drugs. But if the virus mutates substantially, the currently available drugs might be ineffective because they only target one portion of the virus, Professor Robert Linhardt said. By targeting both...

bc8d5ec6422d339b575b5cecd258456f1
2009-05-20 07:04:04

Approach targets both the H and N portions of the virus What happens if the next big influenza mutation proves resistant to the available anti-viral drugs? This question is presenting itself right now to scientists and health officials this week at the World Health Assembly in Geneva, Switzerland, as they continue to do battle with H1N1, the so-called swine flu, and prepare for the next iteration of the ever-changing flu virus. Promising new research announced by Rensselaer Polytechnic...