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Latest Virulence Stories

2012-01-30 14:13:40

Escherichia coli bacteria thrive in the lower intestine of humans and other animals, including birds. Most are vital constituents of the healthy gut flora, but certain forms of E. coli cause a range of diseases in both humans and poultry. In this month´s issue of the journal PLoS ONE, a team of researchers at Arizona State University´s Biodesign Institute investigates disease-causing E. coli strains known as APEC (for Avian Pathogenic E. coli).  By studying circular segments...

2012-01-09 19:54:23

Researchers at Duke University Medical Center have developed a new way to identify the genes of harmful microbes, particularly those that have been difficult to study in the laboratory. This new method uses chemicals to create mutant bacteria, followed by genomic sequencing to identify all mutations. By looking for common genes that were mutated in Chlamydia sharing a particular trait, the investigators were able to rapidly "zero in" on the genes responsible for that trait. The approach...

2011-12-13 14:47:07

Single-celled bacteria communicate with each other using coded messages to coordinate attacks on their targets. Until now, the diversity of codes employed by these invading bacteria was thought to be extremely limited. However, a new report published Dec. 12 in PLoS ONE reveals bacterial communication by a novel, previously undescribed signal type — and, as is often the case in evolutionary stories, some plants have evolved a complementary cypher-breaking detection system that...

2011-12-10 01:49:36

• The study focuses on the protein Ler, which is present in the pathogenic strains of Escherichia coli that caused an outbreak of food poisoning in Germany last May. • Ler binds multiple DNA sequences, thereby activating numerous genes responsible for bacterial virulence. • The findings of the study have been published in PloS Pathogens. A team headed by scientists from the Institute for Research in Biomedicine (IRB Barcelona) reports how the protein Ler, which is...

2011-12-09 11:51:09

A protein called enhanced disease susceptibility 1 (EDS1) plays a central role in plants' ability to defend themselves from pathogens. But in the almost two decades since it was discovered, how EDS1 works at the molecular level has been a mystery. Solving the mystery will help scientists enhance disease resistance in crops. Two papers published in the Dec. 9 issue of Science (http://www.sciencemag.org/magazine) demonstrate how EDS1 activates different components of the plant immune system,...

2011-11-18 03:55:38

Results in 'Science' could identify new ways to design vaccines, antibiotics A University of Louisville scientist has determined for the first time how the bacterium that causes Legionnaires´ disease manipulates our cells to generate the amino acids it needs to grow and cause infection and inflammation in the lungs. The results are published online today (Nov. 17) in Science. Yousef Abu Kwaik, Ph.D., the Bumgardner Endowed Professor in Molecular Pathogenesis of Microbial Infections...

2011-11-04 22:51:05

For decades, scientists and farmers have attempted to understand how a bacterial pathogen continues to damage tomatoes despite numerous agricultural attempts to control its spread. Pseudomonas syringae pv. tomato is the causative agent of bacterial speck disease of tomato (Solanum lycopersicum), a disease that occurs worldwide and causes severe reduction in fruit yield and quality, particularly during cold and wet springs. In the spring of 2010, for example, an outbreak in Florida and...

2011-10-11 09:17:51

Antivirulence drugs disarm pathogens rather than kill them, and although they could be effective in theory, antivirulence drugs have never been tested in humans. A new study to be published in the online journal mBio® on Tuesday, October 18 reveals these drugs have the potential to fight infection while avoiding the pitfalls of drug resistance. Traditional antibiotics aim to kill or stop the growth of pathogens, but antivirulence drugs prevent disease by neutralizing virulence factors,...

2011-08-23 18:33:49

Scientists have discovered that bacteria like E. coli and Salmonella have a sneaky way of making minor alterations to their genes to boost their chances for infection. It's a fascinating discovery made at Ohio State University, which is featured in the Aug. 14 issue of Nature Chemical Biology. This discovery shows how bacteria make tweaks in their genes, and their proteins to gain strength. The team includes research scientist Herve Roy, who joined the University of Central Florida...

2011-07-28 12:43:49

International team publishes comprehensive DNA analysis of outbreak strain and 11 related strains in New England Journal of Medicine An international team of scientists has successfully employed single molecule, real-time (SMRTâ“ž¢) DNA sequencing technology from Pacific Biosciences of California, Inc. (NASDAQ: PACB) to provide valuable insights into the pathogenicity and evolutionary origins of the highly virulent bacterium responsible for the German E. coli...


Latest Virulence Reference Libraries

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2011-04-14 13:29:59

Acinetobacter baumannii is a species of pathogenic bacteria that is resistant to most antibiotics. Some think the disease is killing tens of thousands of U.S. hospital patients each year due to its resistance to drug treatment. It can cause severe pneumonia and infections of the urinary tract, bloodstream, and other parts of the body. It forms opportunistic infections including reports of attacking wounded soldiers and is sometimes abbreviated as MDRAB. It is the most relevant human...

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