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Latest Virulence Stories

2011-11-18 03:55:38

Results in 'Science' could identify new ways to design vaccines, antibiotics A University of Louisville scientist has determined for the first time how the bacterium that causes Legionnaires´ disease manipulates our cells to generate the amino acids it needs to grow and cause infection and inflammation in the lungs. The results are published online today (Nov. 17) in Science. Yousef Abu Kwaik, Ph.D., the Bumgardner Endowed Professor in Molecular Pathogenesis of Microbial Infections...

2011-11-04 22:51:05

For decades, scientists and farmers have attempted to understand how a bacterial pathogen continues to damage tomatoes despite numerous agricultural attempts to control its spread. Pseudomonas syringae pv. tomato is the causative agent of bacterial speck disease of tomato (Solanum lycopersicum), a disease that occurs worldwide and causes severe reduction in fruit yield and quality, particularly during cold and wet springs. In the spring of 2010, for example, an outbreak in Florida and...

2011-10-11 09:17:51

Antivirulence drugs disarm pathogens rather than kill them, and although they could be effective in theory, antivirulence drugs have never been tested in humans. A new study to be published in the online journal mBio® on Tuesday, October 18 reveals these drugs have the potential to fight infection while avoiding the pitfalls of drug resistance. Traditional antibiotics aim to kill or stop the growth of pathogens, but antivirulence drugs prevent disease by neutralizing virulence factors,...

2011-08-23 18:33:49

Scientists have discovered that bacteria like E. coli and Salmonella have a sneaky way of making minor alterations to their genes to boost their chances for infection. It's a fascinating discovery made at Ohio State University, which is featured in the Aug. 14 issue of Nature Chemical Biology. This discovery shows how bacteria make tweaks in their genes, and their proteins to gain strength. The team includes research scientist Herve Roy, who joined the University of Central Florida...

2011-07-28 12:43:49

International team publishes comprehensive DNA analysis of outbreak strain and 11 related strains in New England Journal of Medicine An international team of scientists has successfully employed single molecule, real-time (SMRTâ“ž¢) DNA sequencing technology from Pacific Biosciences of California, Inc. (NASDAQ: PACB) to provide valuable insights into the pathogenicity and evolutionary origins of the highly virulent bacterium responsible for the German E. coli...

2011-07-25 14:14:10

Naturally produced by the body, nitric oxide disrupts pathogens' metabolism A new target for nitric oxide has been revealed in studies of how it inhibits the growth of Salmonella. This bacterium is a common cause of food-poisoning. "Nitric oxide is naturally produced in the nose and the gut and other tissues in the body to ward off infection," explained the senior author of the paper, Dr. Ferric Fang. He is a University of Washington (UW) professor of laboratory medicine, microbiology and...

2011-07-20 16:51:20

Researchers at Duke University Medical Center have discovered a way to block the damaging actions of Chlamydia, the bacteria responsible for the largest number of sexually transmitted infections in the United States. The team, which included Duke University microbiologists and chemists, designed a molecule that takes away the bacteria's self-defense mechanisms. The therapies that could come from this discovery mark a new type of antimicrobial approach. Instead of directly killing the...

2011-06-27 21:18:15

Scientists have discovered the tool that bacteria normally found in our mouths use to invade heart tissue, causing a dangerous and sometimes lethal infection of the heart known as endocarditis. The work raises the possibility of creating a screening tool "“ perhaps a swab of the cheek, or a spit test "“ to gauge a dental patient's vulnerability to the condition. The identification of the protein that allows Streptococcus mutans to gain a foothold in heart tissue is reported in the...

2011-06-22 16:16:24

Scarlet fever has revealed unusual high infect rate in HK this year. So far, 466 children were infected and 2 of them dead. Scarlet fever is caused by Streptococcus pyogenes, a gram-positive pathogen that can be transmitted viaskin wound and airborne droplet.  According to the guidance of Hong Kong Center for Disease Control (HK CDC), Hong Kong University (HKU) and their partners today released the draft genome sequence of the S. pyogenes strain that was isolated from a scarlet fever...

2011-06-13 12:31:04

Scientists in Saarbruecken provide free access to the enteric pathogen's genetic regulation data Just a few genes make enterohaemorrhagic E. coli (EHEC) extremely dangerous to humans. If it were not for these genes, EHEC would hardly differ from harmless enteric bacteria. Bioinformatics scientists from the Saarbrcken Cluster of Excellence want to exploit this similarity to find starting points for effective drugs against the EHEC pathogen. In a very short time, the scientists have constructed...


Latest Virulence Reference Libraries

69_6c18294b6ad5d3bd2a21fde1a9e1ea03
2011-04-14 13:29:59

Acinetobacter baumannii is a species of pathogenic bacteria that is resistant to most antibiotics. Some think the disease is killing tens of thousands of U.S. hospital patients each year due to its resistance to drug treatment. It can cause severe pneumonia and infections of the urinary tract, bloodstream, and other parts of the body. It forms opportunistic infections including reports of attacking wounded soldiers and is sometimes abbreviated as MDRAB. It is the most relevant human...

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Word of the Day
cacodemon
  • An evil spirit; a devil.
  • A nightmare.
  • In astrology, the twelfth house of a scheme or figure of the heavens: so called from its signifying dreadful things, such as secret enemies, great losses, imprisonment, etc.
'Cacodemon' comes from a Greek term meaning 'evil genius.'
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