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Latest Von Hippel-Lindau tumor suppressor Stories

2012-09-13 13:34:51

It seems as if a tumor deprived of oxygen would shrink. However, numerous studies have shown that tumor hypoxia, in which portions of the tumor have significantly low oxygen concentrations, is in fact linked with more aggressive tumor behavior and poorer prognosis. It´s as if rather than succumbing to gently hypoxic conditions, the lack of oxygen commonly created as a tumor outgrows its blood supply signals a tumor to grow and metastasize in search of new oxygen sources — for...

2012-07-25 09:33:05

In addition to the well-known risk factor of smoking, chronic obstructive pulmonary disease (COPD) increases lung cancer risk. A University of Colorado Cancer Center study published in the journal Cancer Prevention Research details one novel mechanism of this risk: long-term oxygen depletion stimulates signals that promote tumor growth. In addition, this early study — performed in animal models — shows that tumors fueled by these COPD-induced signals may be especially...

2012-01-30 12:41:07

A new family of proteins which regulate the human body´s ℠hypoxic response´ to low levels of oxygen has been discovered by scientists at Barts Cancer Institute at Queen Mary, University of London and The University of Nottingham. The discovery has been published in the international journal Nature Cell Biology. It marks a significant step towards understanding the complex processes involved in the hypoxic response which, when it malfunctions, can cause and affect the...

2011-12-05 13:06:47

Study published online today in Nature Genetics BGI, the world's largest genomics organization, announced that a study on frequent mutation of genes encoding ubiquitin-mediated proteolysis pathway (UMPP) components in clear cell renal cell carcinoma (ccRCC) is published online today in Nature Genetics. In addition to BGI, co-leaders of the study included Peking University Shenzhen Hospital, Shenzhen Second People's Hospital, among others. The study reveals that alteration of UMPP may...

2011-06-06 13:44:41

Johns Hopkins researchers solve mystery of Warburg effect It's long been known that cancer cells eat a lot of sugar to stay alive. In fact, where normal, noncancerous cells generate energy from using some sugar and a lot of oxygen, cancerous cells use virtually no oxygen and a lot of sugar. Many genes have been implicated in this process and now, reporting in the May 27 issue of Cell, researchers at the Johns Hopkins University School of Medicine have discovered that this so-called Warburg...

2011-03-30 17:03:09

Researchers at UT Southwestern Medical Center have discovered genetic pathways to starve selectively kidney cancer cells. Two separate studies indicate that both rare and common cases of kidney cancer may be susceptible to a new class of drugs that inhibits cancer cells from generating the energy needed to survive. In one study, available online and scheduled for the May 5 issue of the journal Oncogene, researchers found that inactivating the gene von Hippel-Lindau (VHL) in mice blocked cells...

2010-12-13 07:30:00

BOSTON, Dec. 13, 2010 /PRNewswire/ -- The second episode in a three-part series on Grey's Anatomy features a patient with von Hippel-Lindau disease (VHL). The next new episode in the show is expected to air on January 6. The first episode, "Adrift and at Peace," aired Dec. 2 (http://tinyurl.com/vhlstory1). VHL is a rare disease, a genetic cancer syndrome that causes a series of tumors in many different parts of the body. It is hard to diagnose, but getting a diagnosis is not the end of...


Word of the Day
negawatt
  • A unit of saved energy.
Coined by Amory Lovins, chairman of the Rocky Mountain Institute as a contraction of negative watt on the model of similar compounds like megawatt.