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Latest Von Hippel-Lindau tumor suppressor Stories

2008-09-24 03:00:12

By Yeom, Chan Joo Chung, June-Key; Kang, Joo Hyun; Jeon, Yong Hyun; Kim, Kwang Il; Jin, Yong Nan; Lee, You Mie; Jeong, Jae Min; Lee, Dong Soo Hypoxia-inducible factor-1 (HIF-1) is a transcription factor of hypoxic response in cancer cells and is associated with tumor progression, angiogenesis, metastasis, and resistance to therapy. We assessed whether the human sodium iodide symporter (NIS) reporter systems can be used to visualize transcriptional activation of HIF- 1 in C6 glioma. Methods:...

2008-07-07 12:00:12

Kidney cancer patients generally have one option for beating their disease: surgery to remove the organ. But that could change, thanks to a new molecule found by Stanford University School of Medicine researchers that kills kidney cancer cells. Ideally, the researchers said, a drug created from this molecule would help fight the life-threatening disease while leaving patients' kidneys intact. "You now have a potential means of going after a disease that's been difficult to treat," said...

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2007-04-05 15:00:00

By MARILYNN MARCHIONE The most infamous feud in American folklore, the long-running battle between the Hatfields and McCoys, may be partly explained by a rare, inherited disease that can lead to hair-trigger rage and violent outbursts. Dozens of McCoy descendants apparently have the disease, which causes high blood pressure, racing hearts, severe headaches and too much adrenaline and other "fight or flight" stress hormones. No one blames the whole feud on this, but doctors say it could...

2005-08-15 13:29:35

A new research study reveals that a diverse group of apparently unrelated genes that are associated with pheochromocytoma intersect at a common pathway that drives the necessary culling of cells. Mutations in these genes disrupt the normal disposal of unneeded or damaged cells during development, thereby allowing potentially dangerous premalignant cells that should not have survived to persist. The mechanism described in the work, published in the August issue of Cancer Cell, may play a role...

2005-08-15 13:27:32

A new study published in the August issue of Cancer Cell may bring good news for the hundreds of thousands of cancer patients who undergo radiation therapy each year. Scientists report that they have a better understanding of the complex effects of radiation on tumor biology and that specific radiation treatment regimens may enhance the effectiveness of radiotherapy, even in tumor populations that have been notoriously difficult to treat. In an earlier study, Dr. Mark W. Dewhirst and...

2005-08-01 18:06:03

COLUMBUS, Ohio - Scientists have identified some of the very earliest genetic changes involved in the development of lung cancer and have incorporated them into a new strain of mouse that develops the disease in much the same way that humans do. The discoveries, reported in the August 1 issue of Cancer Research, open the door to the possibility of new, targeted treatments that could be offered at the very first signs of lung cancer, when the possibility of a cure is most likely. Creating...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.