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Last updated on April 17, 2014 at 1:21 EDT

Latest Wallerian degeneration Stories

2014-04-01 14:58:41

A new discovery suggests it could one day be possible to chemically reprogram and repair damaged nerves after spinal cord injury or brain trauma. Researchers from Imperial College London and the Hertie Institute, University of Tuebingen have identified a possible mechanism for re-growing damaged nerve fibres in the central nervous system (CNS). This damage is currently irreparable, often leaving those who suffer spinal cord injury, stroke or brain trauma with serious impairments like loss...

2012-11-01 23:10:49

A gene that is associated with regeneration of injured nerve cells has been identified by scientists at Penn State University and Duke University. The team, led by Melissa Rolls, an assistant professor of biochemistry and molecular biology at Penn State, has found that a mutation in a single gene can entirely shut down the process by which axons -- the parts of the nerve cell that are responsible for sending signals to other cells -- regrow themselves after being cut or damaged. "We are...

2012-04-02 10:04:42

A new animal model of nerve injury has brought to light a critical role of an enzyme called Nmnat in nerve fiber maintenance and neuroprotection. Understanding biological pathways involved in maintaining healthy nerves and clearing away damaged ones may offer scientists targets for drugs to mitigate neurodegenerative diseases such as Huntington's and Parkinson's, as well as aid in situations of acute nerve damage, such as spinal cord injury. University of Pennsylvanian biologists developed...

2010-06-15 14:13:26

Antibodies "” warrior proteins the immune system makes to defend the body against invading pathogens such as viruses and bacteria "” have a gentler side nobody knew about until now: They function not only as soldiers but also as nurses. And researchers at the Stanford University School of Medicine now think antibodies' absence in the central nervous system (the brain and spinal cord) may be a key part of the reason why nerve damage there doesn't get naturally repaired in humans....

2010-01-26 12:20:40

Scientists at the Babraham Institute have discovered a novel survival factor whose rapid transport along nerve cells is crucial for keeping them alive. The same factor seems likely to be needed to keep our nerves healthy as we age. These findings, published today in the online, open-access journal PLoS Biology, show that a molecule known as Nmnat2 provides a protective function; in its absence healthy, uninjured nerve cells start to degenerate and boosting levels of Nmnat2 can delay...

2009-10-28 22:05:28

Scientists at the University of California, San Diego School of Medicine report that regeneration of central nervous system axons can be achieved in rats even when treatment delayed is more than a year after the original spinal cord injury. "The good news is that when axons have been cut due to spinal cord injury, they can be coaxed to regenerate if a combination of treatments is applied," said lead author Mark Tuszynski, MD, PhD, professor of neurosciences and director of the Center for...

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2009-08-02 12:46:32

In a major step in spinal cord injury research, scientists at the University of California, San Diego School of Medicine have demonstrated that regenerating axons can be guided to their correct targets and re-form connections after spinal cord injury. Their findings will be published in the advance online edition of the journal Nature Neuroscience on August 2. In the last few years, researchers have shown that the severed wires of the spinal cord, called axons, can be induced to regenerate...

2009-07-21 14:55:00

In the July issue of Biomaterials, published by Elsevier, researchers from the University of Central Florida (UCF) report on the first lab-grown motor nerves that are insulated and organized just like they are in the human body. The model system will drastically improve understanding of the causes of myelin-related conditions, such as diabetic neuropathy and later, possibly multiple sclerosis (MS). In addition, the model system will enable the discovery and testing of new drug therapies for...