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2014-04-18 15:52:50

Finding could influence cancer care and regenerative medicine An international team led by researchers at UC Davis has shown that the cyclin B1/Cdk1 protein complex, which plays a key role in cell division, also boosts the mitochondrial activity to power that process. This is the first time the complex has been shown to perform both jobs. This newfound ability could make cyclin B1/Cdk1 an excellent target to control cellular energy production, potentially advancing cancer care and...

2013-09-09 20:31:55

University of Montreal, McGill researchers develop new method to link signaling molecules to target regulators of cell division A team of University of Montreal and McGill University researchers have devised a method to identify how signaling molecules orchestrate the sequential steps in cell division. In an article published online today in the Proceedings of the National Academy of Sciences, the scientists explain how they could track the relationship between signaling molecules and...

2013-03-13 18:06:19

A better 'mousetrap' discovered in fruit flies might stop a human cancer-driving kinase in its tracks A seemingly obscure gene in the female fruit fly that is only active in cells that will become eggs has led researchers at the Stowers Institute for Medical Research to the discovery of a atypical protein that lures, traps, and inactivates the powerful Polo kinase, widely considered the master regulator of cell division. Its human homolog, Polo-like kinase-1 (Plk1), is misregulated in many...

2012-08-14 12:02:29

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have discovered a mechanism that explains how some cancer cells “hijack” a biological process to potentially activate cell growth and the survival of cancer gene expression. Their study appeared in a recent issue of Nature Structural & Molecular Biology. The newly discovered mechanism involves histones (highly alkaline proteins found in cells that package and order DNA), and in this...

2012-03-28 17:20:49

Later-stage cancers thrive by finding detours around roadblocks that cancer drugs put in their path, but a Purdue University biochemist is creating maps that will help drugmakers close more routes and develop better drugs. Kinase enzymes deliver phosphates to cell proteins in a process called phosphorylation, switching a cellular function on or off. Irregularities in phosphorylation can lead to uncontrolled cell growth and are a hallmark of cancer. Many successful cancer drugs are...

2011-12-03 11:08:04

MK 1775, a small, selective inhibitor molecule, has been found to be active against many sarcomas when tested by researchers at Moffitt Cancer Center in Tampa, Fla. Their findings, recently appearing in Molecular Cancer Therapeutics, published by the American Association for Cancer Research, suggest that a badly needed new agent against sarcomas - especially sarcomas affecting children - may be at hand. According to corresponding author Soner Altiok, M.D., Ph.D., sarcomas are rare forms of...

How Old Yeast Cells Send Off Their Daughter Cells Without The Baggage Of Old Age
2011-11-24 04:40:35

[ Watch the Video ] The accumulation of damaged protein is a hallmark of aging that not even the humble baker's yeast can escape. Yet, aged yeast cells spawn off youthful daughter cells without any of the telltale protein clumps. Now, researchers at the Stowers Institute for Medical Research may have found an explanation for the observed asymmetrical distribution of damaged proteins between mothers and their youthful daughters. Reporting in the Nov. 23, 2011, issue of Cell the research...

2011-07-07 19:23:55

Scripps Research Institute scientists have discovered a basic mechanism that can enable developing cancer cells to sustain abnormal growth. The finding is expected to lead to the targeting of this mechanism with drugs and diagnostic techniques. The study, which recently appeared in the early online edition of the Proceedings of the National Academy of Sciences, illuminates the roles of two nearly identical proteins, Cks1 and Cks2. These proteins were known to be overexpressed in many cancers,...

2011-04-19 13:30:02

A new study shows how inflammation can help cause cancer. Chronic inflammation due to infection or to conditions such as chronic inflammatory bowel disease is associated with up to 25 percent of all cancers. This study by researchers at the Ohio State University Comprehensive Cancer Center "“ Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC "“ James) found that inflammation stimulates a rise in levels of a molecule called microRNA-155 (miR-155)....


Word of the Day
Cthulhu
  • A gigantic fictional humanoid alien god being described with a head resembling an octopus and dragon wings and claws, around whom an insane cult developed.
  • Pertaining to the mythos of Cthulhu and additional otherworldly beings created by H. P. Lovecraft or inspired by his writings and imitators.
This word was invented in 1926 by H.P. Lovecraft for his short story, 'The Call of Cthulhu.' 'Cthulhu' may be based on the word 'chthonic,' which in Greek mythology refers to the underworld.
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