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Latest Wellcome Trust Sanger Institute Stories

2014-08-12 08:30:12

SAN DIEGO, Aug. 12, 2014 /PRNewswire/ -- BioNano Genomics announced today the purchase of an Irys(TM )System by the Wellcome Trust Sanger Institute, one of the world's leading genome centers, located near Cambridge, UK. The Sanger Institute made the largest single contribution to the gold standard sequence for the Human Genome Project and today is focused on the role of genetics in health and disease. The Sanger Institute purchased BioNano's Irys platform to detect structural...

dna single-cell technique
2014-07-22 03:30:21

Biotechnology and Biological Sciences Research Council (BBSRC) Researchers develop new, powerful single-cell technique to study environmental effects on DNA Researchers at the BBSRC-funded Babraham Institute, in collaboration with the Wellcome Trust Sanger Institute Single Cell Genomics Centre, have developed a powerful new single-cell technique to help investigate how the environment affects our development and the traits we inherit from our parents. The technique can be used to map...

2014-05-12 13:49:54

Wellcome Trust Sanger Institute New atlas of molecules paves the way for improved understanding of metabolic diseases In the most comprehensive exploration of the association between genetic variation and human metabolism, researchers have provided unprecedented insights into how genetic variants influence complex disease and drug response through metabolic pathways. The team has linked 145 genetic regions with more than 400 molecules involved in human metabolism in human blood. This...

2014-04-14 14:24:06

Genetic evidence supports role of gene family in cancer development Researchers have found a major piece of genetic evidence that confirms the role of a group of virus-fighting genes in cancer development. Our understanding of the biological processes that cause cancer is limited. UV light and smoking are two well-understood cancer-causing processes. Exposure to either of these processes causes distinguishable patterns of genetic damage, or 'signatures', on the genome that can lead to...

2014-03-16 16:20:46

CAMBRIDGE, England, March 16, 2014 /PRNewswire/ -- Kymab, a monoclonal antibody biopharmaceutical company founded on research from the Wellcome Trust Sanger Institute, announced today the publication in Nature Biotechnology of a paper describing its breakthrough therapeutic antibody discovery technology, Kymouse(TM) (http://dx.doi.org). Scientists at Kymab have engineered a mouse with the full set of genes encoding the human antibody repertoire, calling this...

2014-02-24 07:54:55

Barbara K. Kennedy, Penn State University 23 February 2014 — Two teams have independently discovered that a single regulatory protein acts as the master genetic switch that triggers the development of male and female sexual forms (termed gametocytes) of the malaria parasite, solving a long-standing mystery in parasite biology with important implications for human health. The protein, AP2-G, is necessary for activating a set of genes that initiate the development of gametocytes -- the...

2014-01-22 12:25:32

Largest exome studies to date establish critical new resources for biomedical community NEW YORK, Jan. 22, 2014 /PRNewswire-USNewswire/ -- The Icahn School of Medicine at Mount Sinai today announced the publication of two papers in the journal Nature that reveal new information about the genetic complexity underpinning schizophrenia. These collaborative studies represent the largest exome sequencing efforts to date to elucidate this mental illness, and together found that the disorder is...

2013-12-24 13:35:52

Genetic screening identifies genes driving resistance with a guide RNA library Researchers have developed a method to create a comprehensive library of mutations across all genes in the mouse genome. This library can be used to examine the role of every gene in different cell types. CRISPR technology uses the DNA-cutting enzyme Cas9, with the help of a guide RNA sequence, to find and modify genetic targets. Scientists can easily engineer multiple new guide RNAs using standard molecular...

Barber Pole Worm Genome Provides Essential Platform To Understand Drug Resistance In Worms
2013-08-28 12:59:38

Wellcome Trust Sanger Institute Researchers have identified five enzymes that are essential to the survival of a parasitic worm that infects livestock worldwide and is a great threat to global food security. Two of these proteins are already being studied as potential drug targets against other pathogens. The team sequenced the genome of Haemonchus contortus, or the barber pole worm, a well-studied parasitic worm that resides in the gut of sheep and other livestock globally. This genome...


Word of the Day
cock-a-hoop
  • Exultant; jubilant; triumphant; on the high horse.
  • Tipsy; slightly intoxicated.
This word may come from the phrase 'to set cock on hoop,' or 'to drink festively.' Its origin otherwise is unclear. A theory, according to the Word Detective, is that it's a 'transliteration of the French phrase 'coq a huppe,' meaning a rooster displaying its crest ('huppe') in a pose of proud defiance.' Therefore, 'cock-a-hoop' would 'liken a drunken man to a boastful and aggressive rooster.'
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