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Latest Wellcome Trust Sanger Institute Stories

2014-05-12 13:49:54

Wellcome Trust Sanger Institute New atlas of molecules paves the way for improved understanding of metabolic diseases In the most comprehensive exploration of the association between genetic variation and human metabolism, researchers have provided unprecedented insights into how genetic variants influence complex disease and drug response through metabolic pathways. The team has linked 145 genetic regions with more than 400 molecules involved in human metabolism in human blood. This...

2014-04-14 14:24:06

Genetic evidence supports role of gene family in cancer development Researchers have found a major piece of genetic evidence that confirms the role of a group of virus-fighting genes in cancer development. Our understanding of the biological processes that cause cancer is limited. UV light and smoking are two well-understood cancer-causing processes. Exposure to either of these processes causes distinguishable patterns of genetic damage, or 'signatures', on the genome that can lead to...

2014-03-16 16:20:46

CAMBRIDGE, England, March 16, 2014 /PRNewswire/ -- Kymab, a monoclonal antibody biopharmaceutical company founded on research from the Wellcome Trust Sanger Institute, announced today the publication in Nature Biotechnology of a paper describing its breakthrough therapeutic antibody discovery technology, Kymouse(TM) (http://dx.doi.org). Scientists at Kymab have engineered a mouse with the full set of genes encoding the human antibody repertoire, calling this...

2014-02-24 07:54:55

Barbara K. Kennedy, Penn State University 23 February 2014 — Two teams have independently discovered that a single regulatory protein acts as the master genetic switch that triggers the development of male and female sexual forms (termed gametocytes) of the malaria parasite, solving a long-standing mystery in parasite biology with important implications for human health. The protein, AP2-G, is necessary for activating a set of genes that initiate the development of gametocytes -- the...

2014-01-22 12:25:32

Largest exome studies to date establish critical new resources for biomedical community NEW YORK, Jan. 22, 2014 /PRNewswire-USNewswire/ -- The Icahn School of Medicine at Mount Sinai today announced the publication of two papers in the journal Nature that reveal new information about the genetic complexity underpinning schizophrenia. These collaborative studies represent the largest exome sequencing efforts to date to elucidate this mental illness, and together found that the disorder is...

2013-12-24 13:35:52

Genetic screening identifies genes driving resistance with a guide RNA library Researchers have developed a method to create a comprehensive library of mutations across all genes in the mouse genome. This library can be used to examine the role of every gene in different cell types. CRISPR technology uses the DNA-cutting enzyme Cas9, with the help of a guide RNA sequence, to find and modify genetic targets. Scientists can easily engineer multiple new guide RNAs using standard molecular...

Barber Pole Worm Genome Provides Essential Platform To Understand Drug Resistance In Worms
2013-08-28 12:59:38

Wellcome Trust Sanger Institute Researchers have identified five enzymes that are essential to the survival of a parasitic worm that infects livestock worldwide and is a great threat to global food security. Two of these proteins are already being studied as potential drug targets against other pathogens. The team sequenced the genome of Haemonchus contortus, or the barber pole worm, a well-studied parasitic worm that resides in the gut of sheep and other livestock globally. This genome...

2013-08-06 23:17:10

Dr. Cambon-Thomsen of CNRS, Dr. Blomberg of ELIXIR, Dr. Hubbard of Sanger Institute and Dr. Ropers of MPI for Molecular Genetics to lead discussions on the molecular diagnosis of complex diseases with genomics and bioinformatics. Needham, MA (PRWEB) August 06, 2013 Bio-IT World and Cambridge Healthtech Institute today announced the final program and keynote lineup for the Fifth International Clinical Genomics & Informatics Europe Conference. The three-day event will be held 4-6...

2013-05-06 20:33:51

Technology will allow better surveillance of bacterial populations, understanding of vaccine effectiveness A new study led by researchers from Harvard School of Public Health (HSPH) and the Wellcome Trust Sanger Institute in the UK has, for the first time, used genome sequencing technology to track the changes in a bacterial population following the introduction of a vaccine. The study follows how the population of pneumococcal bacteria changed following the introduction of the 'Prevnar'...


Word of the Day
mundungus
  • A stinking tobacco.
  • Offal; waste animal product; organic matter unfit for consumption.
This word comes from the Spanish 'mondongo,' tripe, entrails.