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Latest Wellcome Trust Sanger Institute Stories

2012-03-23 13:12:45

Researchers compare the genome of 2 parasites to explain differences in host range and transmission strategy Researchers have found the subtle genetic differences that make one parasite far more virulent than its close relative. They looked at the evolution of these parasites and found that although their genome architecture still remains similar, the two split from their common ancestor 28 million years ago, approximately four times longer than the human-gorilla split. Toxoplasma is...

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2012-03-13 07:56:05

A recent study posted in Nature Genetics explains that researchers have found that Chlamydia has been evolving differently than previously thought. The researchers used whole genome sequencing to find these results. Their findings show the exchange of DNA between different strains of the STD to form new strains is more common than expected. The researchers came about their findings while working with hospitals to improve their testing and detection of Chlamydia, particularly different...

2012-03-12 12:43:00

COPENHAGEN, Denmark, March 12, 2012 /PRNewswire/ -- The Grete Lundbeck European Brain Research Foundation announced today that The Brain Prize 2012 is jointly awarded to Christine Petit and Karen Steel: 'for their unique, world-leading contributions to our understanding of the genetic regulation of the development and functioning of the ear, and for elucidating the causes of many of the hundreds of inherited forms of deafness.' Inherited conditions render one in a...

2012-03-12 09:57:18

Whole genome analysis of Chlamydia trachomatis highlights risks with current method of tracking In a study released today in Nature Genetics, researchers have found that Chlamydia has evolved more actively than was previously thought. Using whole genome sequencing the researchers show that the exchange of DNA between different strains of Chlamydia to form new strains is much more common than expected. The team highlights that current clinical testing methods do not capture the variation...

Genome Reveals Humans, Gorillas More Alike Than Previously Thought
2012-03-08 07:53:30

Researchers who have completed the genome sequence of the gorilla have discovered that the species is more genetically similar to humans than they had previously thought. The study, which was led by researchers at the UK's Wellcome Trust Sanger Institute and the Baylor College of Medicine (BCM), looked at DNA from a 30-year-old female western lowland gorilla from the San Diego Zoo named Kamilah, Dave Mosher of National Geographic News reported on Wednesday. They began studying the...

Devil's Contagious Cancer Genome Sequenced
2012-02-17 05:48:15

[ Watch the Video ] The Tasmanian devil population is threatened to extinction with a highly contagious cancer. In order to understand the origins of the cancer, researchers have sequenced the complete genome of the cell and traced it back to what they are calling an ℠immortal´ female. Researchers hope by sequencing the genome they can find a way to help the Tasmanian devil. According to Elizabeth Murchison, a Tasmanian native working at the Wellcome Trust Sanger Institute in...

2012-02-17 00:31:25

Researchers develop a new catalogue to help identify gene variations associated with disease A high-quality reference catalogue of the genetic changes that result in the deactivation of human genes has been developed by a team of researchers. This catalogue of loss-of-function (LoF) variants is needed to find new disease-causing mutations and will help us to better understand the normal function of human genes. In addition, the researchers report that each of us is carrying around 20 genes...

2012-01-26 02:11:22

Research led by scientists at the London School of Hygiene & Tropical Medicine has exploited a revolutionary genetic technique to discover how human African Trypanosomiasis (HAT) drugs target the parasite which causes the disease. The new knowledge could help lead to the development of better treatments for the tens of thousands of people in sub-Saharan Africa who are affected each year. The findings, published in Nature, are based on the simultaneous analysis of thousands of genes and...

2012-01-12 21:39:16

A team of geneticists and computational biologists in the UK today reveal how an ancient mechanism is involved in gene control and continues to drive genome evolution. The new study is published in the journal Cell. To function properly, mammalian tissues require the protein CTCF, which has several key activities including the regulation of genes and interaction with proteins in the cell's nucleus to alter gene activity. CTCF acts by binding to DNA and plays a role in diseases such as HIV...

2011-12-20 18:10:38

A new candidate malaria vaccine with the potential to neutralize all strains of the most deadly species of malaria parasite has been developed by a team led by scientists at the University of Oxford. The results of this new vaccine independently confirm the utility of a key discovery reported last month from scientists at the Wellcome Trust Sanger Institute who had identified this target within the parasite as a potential 'Achilles' heel' that could hold significant promise for vaccine...