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Latest Wellcome Trust Sanger Institute Stories

2011-09-27 13:20:42

New genetic insights could facilitate screening for mutation A genomic study of chronic blood cancer - a precursor to leukaemia - has discovered gene mutations that could enable diagnosis using only a blood test, avoiding the need for an invasive and painful bone marrow biopsy. Researchers at the Wellcome Trust Sanger Institute identified the SF3B1 gene as being frequently mutated in myelodysplasia, one of the most common forms of blood cancer. Myelodysplasia is particularly prevalent...

Researchers Sequence DNA Of 17 Common Types Of Lab Mice
2011-09-16 09:53:31

  An international team of researchers have sequenced the genomes of 17 different strains of mice in what the National Science Foundation (NSF) is calling "an achievement that lays the groundwork for the identification of genes responsible for“¦ diseases that afflict both mice and humans." The work, which was spearheaded by researchers at the Wellcome Trust Sanger Institute and the University of Oxford, gives researchers the genetic blueprints of multiple varieties of...

2011-08-31 20:24:25

Study of metabolites reveals health implications from small molecules Researchers have undertaken the most comprehensive investigation of genetic variance in human metabolism and discovered new insights into a range of common diseases. Their work has revealed 37 new variants that are associated with concentrations of metabolites in the blood. Many of these match variants associated with diseases such as chronic kidney disease, type 2 diabetes and blood clotting. The team conducted the...

2011-08-25 14:53:06

New gene identified that affects levels of pain in osteoarthritis following use of 1000 Genomes study data Researchers have today revealed a new gene associated with osteoarthritis. This is only the third gene to be identified for this painful and debilitating disease that affects more than 40 per cent of people aged more than 70 years. The disease-associated variant, in the gene MCF2L, was discovered when Wellcome Trust Sanger Institute researchers used data from the 1000 Genomes...

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2011-08-21 14:54:24

While sequencing the DNA of a member of the kangaroo family for the first time, an international team of researchers believe they have identified the gene responsible for the creature's hop, Judith Burns of BBC News reported on Friday. The project, which is detailed in the latest issue of the journal Genome Biology, centers around the tammar wallaby (Macropus eugenii), a smaller species of kangaroo located on islands off the south and west coasts of Australia. According to Burns, this...

2011-07-01 12:52:11

1 step closer to understanding the biology behind disease-associated genetic variants Researchers have developed a new strategy to improve the outcome of genome-wide association (GWA) studies. GWA studies involve rapidly scanning markers across the genomes of many people. By doing this, scientists can look for the association between certain genetic markers or variants within the population, and a particular trait, including disease. However, the challenge is to take these initial association...

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2011-06-13 05:30:00

Researchers have discovered that parents give their children about 60 new genome mutations. The new value is reported in the first-ever direct study of new mutations coming from mother and father. Researchers measured directly the number of mutations in two families, using whole genome sequences from the 1000 Genomes Project.  The results also reveal that human genomes, like all genomes, are changed by the forces of mutation. New mutations are the ultimate source from which new...

2011-06-08 14:07:24

Dual approach will find mutations in osteosarcoma and develop tools to monitor disease in patients A new study into osteosarcoma - cancer of the bone - will use advances in genomic research and analysis to identify new genes that give rise to the condition and to create personalised blood tests for children and young adults with the condition. The study is funded by Skeletal Action Cancer Trust, SCAT. It is hoped that the results of this new study will help doctors improve treatment of this...

2011-02-02 19:41:40

Comprehensive catalogue uncovers genetic sequence of large-scale differences between human genomes A detailed analysis of data from 185 human genomes sequenced in the course of the 1000 Genomes Project, by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, in collaboration with researchers at the Wellcome Trust Sanger Institute in Cambridge, UK, as well as the University of Washington and Harvard Medical School, both in the USA, has identified the genetic...

2011-02-02 19:40:17

A study from the 1000 Genomes Project yields data for analyzing structural variants in DNA Advances in DNA sequencing technology have revolutionized biomedical research and taken us another step forward in personalized medicine. Now, scientists led by Brigham and Women's Hospital (BWH), Harvard Medical School (HMS), the Broad Institute, the Wellcome Trust Sanger Institute (WTSI), the University of Washington, and the European Molecular Biology Laboratory, have developed a new framework for...


Word of the Day
grass-comber
  • A landsman who is making his first voyage at sea; a novice who enters naval service from rural life.
According to the OED, a grass-comber is also 'a sailor's term for one who has been a farm-labourer.'