Latest Wellcome Trust Sanger Institute Stories

2011-01-28 00:11:29

Research shows how bacteria keep ahead of vaccines and antibiotics New research provides the first detailed genetic picture of an evolutionary war between Streptococcus pneumoniae bacteria and the vaccines and antibiotics used against it over recent decades. Large-scale genome sequencing reveals patterns of adaptation and the spread of a drug-resistant lineage of the S. pneumoniae bacteria. The study unmasks the genetic events by which bacteria such as S. pneumoniae respond rapidly to new...

2011-01-06 16:34:18

Chromosome crisis common in cancer causation Remarkable new research overthrows the conventional view that cancer always develops in a steady, stepwise progression. It shows that in some cancers, the genome can be shattered into hundreds of fragments in a single cellular catastrophe, wreaking mutation on a massive scale. The scars of this chromosomal crisis are seen in cases from across all the common cancer types, accounting for at least one in forty of all cancers. The phenomenon is...

2010-12-20 08:29:58

A set of brain proteins is found to play a role in over 100 brain diseases and provides a new insight into evolution of behavior In research published Sunday, scientists have studied human brain samples to isolate a set of proteins that accounts for over 130 brain diseases. The paper also shows an intriguing link between diseases and the evolution of the human brain. Brain diseases are the leading cause of medical disability in the developed world according to the World Health Organization...

2010-10-28 05:40:00

Researchers unveiled early results from the pilot phase of the 1000 Genomes Project on Wednesday, revealing the most complete inventory to date of the millions of DNA variations between individuals. The findings are estimated to contain 95 percent of the genetic variation of any person on Earth, and shed light on the genetic roots of diseases and why some people are at greater risk than others for developing illnesses such as diabetes or cancer.  The more subtle genetic variations also...

2010-10-27 20:40:36

Pancreatic cancer genomes show remarkable mutation effects In new research published today, researchers uncover evolution in action in cancer cells. They show the forces of evolution in pancreatic tumours mean that not only is cancer genetically different between different patients, but each new focus of cancer spread within a patient has acquired distinct mutations. Effectively, ten different foci of cancer spread are ten different, but related, tumours. The complexity of pancreatic cancer...

2010-10-15 01:15:25

Powerful mutation tool identifies new cancer genes Researchers have developed a genetic tool in mice to speed the discovery of novel genes involved in cancer. The system "“ called PiggyBac "“ has already been used by the team to identify novel candidate cancer-causing genes. This new development of the PiggyBac system makes it a powerful addition to the armoury of genetic methods available to researchers for picking apart the genetic causes of cancer. It will complement advances...

2010-09-15 17:26:41

A gene network behind hardening of the arteries and coronary heart disease has been identified by a team of scientists from Australia, Europe and the United Kingdom. Their findings expose potential targets for the treatment of heart disease. Dr Michael Inouye, a postdoctoral fellow at the Walter and Eliza Hall Institute, began the study at the Wellcome Trust Sanger Institute in the UK and completed it earlier this year at the Walter and Eliza Hall Institute. Researchers from Finland's...

2010-09-01 20:42:36

HapMap 3 points the way forward for human genetics studies New findings show the value of genetic studies across human populations and the value of the latest DNA sequencing technologies to interrogate genetic variation. The results, from the latest phase of the international HapMap Project, are reported in Nature. The researchers' extensive study of genetic variation in multiple populations will form a framework for future genetic studies of variation and disease: their findings highlight...

2010-08-30 06:30:00

An international team of scientists has identified a genetic risk factor associated with common migraines for the first time and say the research could lead to new treatments in the prevention of migraine attacks. Researchers studied the genetic data of 50,000 people from Finland, Germany and the Netherlands and found that patients with a certain DNA variant that affects regulation of a certain brain chemical have a greater risk of developing migraines. The study suggests that a buildup of...

2010-07-12 12:46:13

A controversial new study, commissioned by the Royal Society of the United Kingdom, will analyze how population growth will impact sustainable development and the economy, according to a statement release by the organization on Monday. "The Royal Society has decided that it is time for a comprehensive review of the science, looking at the extent to which population will be a significant variable in rates of progress towards sustainable economic and social development over the next thirty...

Word of the Day
  • Remarkable; prodigious.
  • Audacious; gutsy.
  • Completely; extremely.
  • Audaciously; boldly.
  • Impressively great in size; enormous; extraordinary.
This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'