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Latest Wellcome Trust Sanger Institute Stories

2010-04-12 11:22:46

Scientists at the University of Liverpool have discovered that dangerous strains of Salmonella are beginning to emerge in people infected with HIV in Africa. Their research has found that, in adults with HIV, new African Salmonellae can cause severe disease by invading cells in the blood and bone marrow, where they can hide away, allowing them to evolve into more dangerous, multi-drug resistant strains over time. This is made possible by the loss of immune cells that occurs in HIV which...

2010-02-17 12:54:56

Screening cancer genomes for the driver mutations in tumor suppressor genes A new study of mutations in cancer genomes shows how researchers can begin to distinguish the 'driver' mutations that push cells towards cancer from the 'passenger' mutations that are a by-product of cancer cell development. The study also shows that at least one in nine genes can be removed without killing human cells. Many cancer genomes are riddled with mutations. The vast majority of these are likely to be...

2010-02-04 14:55:00

IPSWICH, Mass., Feb. 4 /PRNewswire/ -- As an important supplier to the Wellcome Trust Sanger Institute, New England Biolabs is pleased to announce that the Sanger Institute will use New England Biolabs as one of its suppliers for next-generation sequencing library construction reagents. (Logo: http://www.newscom.com/cgi-bin/prnh/20090921/NE79207LOGO-b ) "We are extremely pleased that the Wellcome Trust Sanger Institute, as a world leading genome center, has determined that our reagents...

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2010-01-25 08:30:00

An international team of researchers has used high resolution genome sequencing to track a particularly virulent strain of MRSA as it traveled between South America, Europe and Southeast Asia. The findings shed light on how these deadly bacteria are able to spread from patient to patient in a single hospital and, on a larger scale of geography and time, between countries and entire continents. The researchers included scientists from Rockefeller University, the Wellcome Trust Sanger Institute...

2010-01-22 00:44:55

Revolutionary strategy for control and prevention of infection For the first time, researchers have shown how transmission of MRSA from one person to another can be precisely tracked in a hospital setting. The team have developed a remarkable new method that can 'zoom' from large-scale inter-continental transmission events to the much finer detail of person-to-person infection of MRSA within a single hospital. The ability to track strains in this way will enable researchers to understand how...

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2010-01-07 08:20:10

Mutations in the genome regulation machinery identified in clear cell renal cell carcinoma In a new study, scientists have searched for mutations in the gene regions of more than 100 kidney cancer samples, the largest number of samples from a single tumor type to be sequenced to date. Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, with 102,000 deaths worldwide each year. It is noteworthy because its pathology "“ all the visible clues to its nature...

2009-12-23 16:54:52

Genome rearrangements in 24 breast cancers The first detailed search of breast cancer genomes to uncover genomic rearrangements is published today. The team characterized the ways in which the human genome is broken and put back together in 24 cases of breast cancer. Rearrangements involve reshuffling and reorganization of the genome and include deletions, duplications and novel juxtaposition of DNA sequences. The study shows that breast cancer samples can differ greatly in the extent to...

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2009-12-17 08:55:00

Geneticists have recently finished analyzing the genomes of two different types of cancer cells, giving them the first complete genetic map of the devastating disease and marking a milestone in the history of cancer research. Working with melanoma and lung cancer cells, scientists at the Wellcome Trust Sanger Institute in the United Kingdom were able to detect all genetic changes in the two rogue cells.  Because cancer cells are more or less normal human body cells that have undergone...

2009-12-06 13:39:05

Scientists in Cambridge have discovered that the loss of a key segment of DNA can lead to severe childhood obesity. This is the first study to show that this kind of genetic alteration can cause obesity. The results are published today in Nature. The study, led by Dr Sadaf Farooqi from the University of Cambridge and Dr Matt Hurles from the Wellcome Trust Sanger Institute, looked at 300 children with severe obesity. The team scanned each child's entire genome looking for types of mutation...

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2009-12-01 07:35:00

Deadly bug targets vulnerable children and adults in Africa Researchers have characterized a new multi drug resistant strain of Salmonella Typhimurium that is causing life-threatening disease in Africa. This type of Salmonella bug normally causes diarrhea and is rarely fatal. The new strain infects vulnerable children and adults in many regions of sub-Saharan Africa leading to death in up to one in four cases. The new genome work, a collaboration between the Wellcome Trust Sanger Institute,...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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