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Latest Wellcome Trust Sanger Institute Stories

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2010-06-21 07:10:00

The completion of three pilot projects designed to determine how best to build an extremely detailed map of human genetic variation begins a new chapter in the international project called 1,000 Genomes, said the director of the Baylor College of Medicine Human Genome Sequencing Center, which is a major contributor to the effort. "Mapping all the shared normal variation in human populations is a critical step to interpreting medically actionable genetic changes," said Dr. Richard Gibbs, also...

2010-06-11 13:13:06

Reprogramming immune system cells to produce natural killer cells for cancer A team of researchers has developed a method to produce cells that kill tumour cells in the lab and prevent tumours forming in mouse models of cancer. Although the current work is in cells and mouse, if the research transfers to human biology, the new type of cell could be a new source for cell-based anticancer therapies. The cells were produced by knocking out a single gene essential in the pathways of development...

2010-04-12 11:22:46

Scientists at the University of Liverpool have discovered that dangerous strains of Salmonella are beginning to emerge in people infected with HIV in Africa. Their research has found that, in adults with HIV, new African Salmonellae can cause severe disease by invading cells in the blood and bone marrow, where they can hide away, allowing them to evolve into more dangerous, multi-drug resistant strains over time. This is made possible by the loss of immune cells that occurs in HIV which...

2010-02-17 12:54:56

Screening cancer genomes for the driver mutations in tumor suppressor genes A new study of mutations in cancer genomes shows how researchers can begin to distinguish the 'driver' mutations that push cells towards cancer from the 'passenger' mutations that are a by-product of cancer cell development. The study also shows that at least one in nine genes can be removed without killing human cells. Many cancer genomes are riddled with mutations. The vast majority of these are likely to be...

2010-02-04 14:55:00

IPSWICH, Mass., Feb. 4 /PRNewswire/ -- As an important supplier to the Wellcome Trust Sanger Institute, New England Biolabs is pleased to announce that the Sanger Institute will use New England Biolabs as one of its suppliers for next-generation sequencing library construction reagents. (Logo: http://www.newscom.com/cgi-bin/prnh/20090921/NE79207LOGO-b ) "We are extremely pleased that the Wellcome Trust Sanger Institute, as a world leading genome center, has determined that our reagents...

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2010-01-25 08:30:00

An international team of researchers has used high resolution genome sequencing to track a particularly virulent strain of MRSA as it traveled between South America, Europe and Southeast Asia. The findings shed light on how these deadly bacteria are able to spread from patient to patient in a single hospital and, on a larger scale of geography and time, between countries and entire continents. The researchers included scientists from Rockefeller University, the Wellcome Trust Sanger Institute...

2010-01-22 00:44:55

Revolutionary strategy for control and prevention of infection For the first time, researchers have shown how transmission of MRSA from one person to another can be precisely tracked in a hospital setting. The team have developed a remarkable new method that can 'zoom' from large-scale inter-continental transmission events to the much finer detail of person-to-person infection of MRSA within a single hospital. The ability to track strains in this way will enable researchers to understand how...

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2010-01-07 08:20:10

Mutations in the genome regulation machinery identified in clear cell renal cell carcinoma In a new study, scientists have searched for mutations in the gene regions of more than 100 kidney cancer samples, the largest number of samples from a single tumor type to be sequenced to date. Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, with 102,000 deaths worldwide each year. It is noteworthy because its pathology "“ all the visible clues to its nature...

2009-12-23 16:54:52

Genome rearrangements in 24 breast cancers The first detailed search of breast cancer genomes to uncover genomic rearrangements is published today. The team characterized the ways in which the human genome is broken and put back together in 24 cases of breast cancer. Rearrangements involve reshuffling and reorganization of the genome and include deletions, duplications and novel juxtaposition of DNA sequences. The study shows that breast cancer samples can differ greatly in the extent to...

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2009-12-17 08:55:00

Geneticists have recently finished analyzing the genomes of two different types of cancer cells, giving them the first complete genetic map of the devastating disease and marking a milestone in the history of cancer research. Working with melanoma and lung cancer cells, scientists at the Wellcome Trust Sanger Institute in the United Kingdom were able to detect all genetic changes in the two rogue cells.  Because cancer cells are more or less normal human body cells that have undergone...


Word of the Day
tessitura
  • The prevailing range of a vocal or instrumental part, within which most of the tones lie.
This word is Italian in origin and comes from the Latin 'textura,' web, structure.