Latest Wellcome Trust Sanger Institute Stories

2009-12-17 08:55:00

Geneticists have recently finished analyzing the genomes of two different types of cancer cells, giving them the first complete genetic map of the devastating disease and marking a milestone in the history of cancer research. Working with melanoma and lung cancer cells, scientists at the Wellcome Trust Sanger Institute in the United Kingdom were able to detect all genetic changes in the two rogue cells.  Because cancer cells are more or less normal human body cells that have undergone...

2009-12-06 13:39:05

Scientists in Cambridge have discovered that the loss of a key segment of DNA can lead to severe childhood obesity. This is the first study to show that this kind of genetic alteration can cause obesity. The results are published today in Nature. The study, led by Dr Sadaf Farooqi from the University of Cambridge and Dr Matt Hurles from the Wellcome Trust Sanger Institute, looked at 300 children with severe obesity. The team scanned each child's entire genome looking for types of mutation...

2009-12-01 07:35:00

Deadly bug targets vulnerable children and adults in Africa Researchers have characterized a new multi drug resistant strain of Salmonella Typhimurium that is causing life-threatening disease in Africa. This type of Salmonella bug normally causes diarrhea and is rarely fatal. The new strain infects vulnerable children and adults in many regions of sub-Saharan Africa leading to death in up to one in four cases. The new genome work, a collaboration between the Wellcome Trust Sanger Institute,...

2009-11-02 07:40:00

A global collaborative has produced a first draft of the genome of a domesticated pig, an achievement that will lead to insights in agriculture, medicine, conservation and evolution. A red-haired Duroc pig from a farm at the University of Illinois will now be among the growing list of domesticated animals that have had their genomes sequenced. Researchers will announce the achievement Monday (Nov. 2) at a meeting at the Wellcome Trust Sanger Institute in Hinxton, England. "The pig is a unique...

2009-10-22 12:32:21

LANL among organizations proposing new genome sequence strategies A team of geneticists at Los Alamos National Laboratory, together with a consortium of international researchers, has recently proposed a set of standards designed to elucidate the quality of publicly available genetic sequencing information. The new standards could eventually allow genetic researchers to develop vaccines more efficiently or help public health or security personnel more quickly respond to potential...

2009-10-16 11:01:48

First high-throughput analysis of every Salmonella Typhi gene For the first time, researchers are able to look at the need for every gene in a bacterial cell in a single experiment. The new method will transform the study of gene activity and the search for weaknesses in bacterial armories. Using a newly developed, next-gen sequencing method, a team established which genes Salmonella Typhi needs to survive and which are more of a luxury. The results and the method will be a boon to scientists...

2009-10-12 07:42:37

Genome-wide meta-analysis identifies 22 regions associated with blood cell traits A new genome-wide association study published Oct. 11 in Nature Genetics begins to uncover the basis of genetic variations in eight blood measurements and the impact those variants can have on common human diseases. Blood measurements, including the number and volume of cells in the blood, are routinely used to diagnose a wide range of disorders, including anemia, infection and blood cell cancers. An...

2009-10-09 10:57:22

In 1996, researchers from major genome sequencing centers around the world convened on the island of Bermuda and defined a finished genome as a gapless sequence with a nucleotide error rate of one or less in 10,000 bases. This effectively set the quality target for the human genome effort and was quickly applied to other genome projects. If a genome sequence didn't meet this stringent criterion, it was simply considered a "draft." More than a decade later, researchers are finding that with...

2009-10-08 09:47:46

New map of copy number variation in the human genome is a resource for human genetics In research published Oct. 7 by Nature, an international team describes the finest map of changes to the structure of human genomes and a resource they have developed for researchers worldwide to look at the role of these changes in human disease. They also identify 75 'jumping genes' - regions of our genome that can be found in more than one location in some individuals. However, the team cautions that they...

2009-10-07 15:50:00

An international research team has issued the most updated map of changes to the structure of human genomes. Writing in the journal Nature, researchers said the new map should provide others with a better approach to fighting human diseases. Researchers also reported the identification of 75 so-called "jumping genes," which are defined as regions of human genomes that can be found in more than one location. They used data compiled through scanning and comparing genomes of 450 people of...

Word of the Day
  • Boughs or branches.
  • Warbling of birds in trees.