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Latest Wellcome Trust Stories

2014-05-23 12:24:55

LA JOLLA, Calif., May 23, 2014 /PRNewswire-USNewswire/ -- The California Institute for Biomedical Research (Calibr) has received a Translation Award from the Wellcome Trust to develop a novel semi-synthetic antibody-based immunotherapy to treat hormone-refractory prostate cancer. The novel therapeutic agent engages the patient's own immune system to selectively destroy prostate tumor cells. This approach offers a potentially more efficacious and safer alternative to traditional...

Single Cell Genome Sequencing Of Malaria Parasites
2014-05-11 03:52:59

Wellcome Trust Single-cell genomics could provide new insight into the biology of Malaria parasites, including their virulence and levels of drug resistance, to ultimately improve treatment and control of the disease, according to new research funded by the Wellcome Trust and the National Institutes of Health. The findings are revealed in a study by researchers at the Texas Biomedical Research Institute and published today in the journal Genome Research. Malaria infections commonly...

2014-04-14 14:24:06

Genetic evidence supports role of gene family in cancer development Researchers have found a major piece of genetic evidence that confirms the role of a group of virus-fighting genes in cancer development. Our understanding of the biological processes that cause cancer is limited. UV light and smoking are two well-understood cancer-causing processes. Exposure to either of these processes causes distinguishable patterns of genetic damage, or 'signatures', on the genome that can lead to...

2014-04-14 14:09:57

The mechanism which underlies the susceptibility of liver disease patients to life-threatening infection has been uncovered by Wellcome Trust-funded medical scientists, who have also suggested a possible treatment to reverse immune suppression in these patients. Liver disease, or cirrhosis, is currently the fifth leading cause of death in the UK. Cirrhosis patients are more than five times more likely to pick up infections in hospital than patients with other chronic conditions, due to...

2014-02-18 13:46:43

Teenage boys who show a combination of depressive symptoms and elevated levels of the 'stress hormone' cortisol are up to fourteen times more likely to develop major depression than those who show neither trait, according to research funded by the Wellcome Trust. In a study published today in the Proceedings of the National Academy of Sciences, researchers from the University of Cambridge have identified the first biomarker – a biological signpost – for major, or clinical, depression....

Wellcome Trust Funding Study To Sequence Genome Of King Richard III
2014-02-12 08:03:41

[ Watch the video: The Whole Genome Sequence of King Richard III ] Lawrence LeBlond for redOrbit.com - Your Universe Online Richard III, a short-lived fifteenth-century king who was discovered buried in an untidy grave underneath a car park in Leicester, England in 2012, is to have his genome sequenced by University of Leicester researchers. The study, funded by Wellcome Trust, the Leverhulme Trust and Prof Sir Alec Jeffreys, is being led by Dr Turi King of the University’s...

Largest Study Yet Of Diabetes Genetics Brings In Data From Different Ethnic Groups
2014-02-10 10:49:21

University of Oxford Seven new genetic regions associated with type 2 diabetes have been identified in the largest study to date of the genetic basis of the disease. DNA data was brought together from more than 48,000 patients and 139,000 healthy controls from four different ethnic groups. The research was conducted by an international consortium of investigators from 20 countries on four continents, co-led by investigators from Oxford University's Wellcome Trust Centre for Human...

2013-12-24 13:35:52

Genetic screening identifies genes driving resistance with a guide RNA library Researchers have developed a method to create a comprehensive library of mutations across all genes in the mouse genome. This library can be used to examine the role of every gene in different cell types. CRISPR technology uses the DNA-cutting enzyme Cas9, with the help of a guide RNA sequence, to find and modify genetic targets. Scientists can easily engineer multiple new guide RNAs using standard molecular...

2013-12-12 12:20:06

One of the first studies to use recently released data from the UK Biobank has provided the strongest evidence yet for a link between fathers' diabetes and low birth weight One of the first studies to use recently released data from the UK Biobank has provided the strongest evidence yet for a link between fathers' diabetes and low birth weight. The research shows that your dad can influence your size at birth and that diabetes genes may explain some of this effect. The study is...


Latest Wellcome Trust Reference Libraries

Caenorhabditis elegans
2014-01-12 00:00:00

Caenorhabditis elegans is a species of parasitic roundworm in the Nematoda phylum. It can be found in temperate regions, in many different areas of the world. It prefers to reside in nutrient rich soils. Its scientific name is derived from the Greek terms Caeno, meaning recent, rhabditis, meaning rod-like, and the Latin term elegans, which means elegant. It was first named by Maupas in 1900, but was not classified in the Caenorhabditis subgenus until 1952 by Osche. Caenorhabditis elegans...

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Word of the Day
callithump
  • A somewhat riotous parade, accompanied with the blowing of tin horns, and other discordant noises; also, a burlesque serenade; a charivari.
'Callithump' is a back-formation of 'callithumpian,' a 'fanciful formation' according to the Oxford English Dictionary. However, the English Dialect Dictionary, says 'Gallithumpians' is a Dorset and Devon word from the 1790s that refers to 'a society of radical social reformers' or 'noisy disturbers of elections and meetings.'
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