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Latest Wnt signaling pathway Stories

2014-06-03 11:48:40

University of Colorado Denver At the 50th Annual Meeting of the American Society for Clinical Oncology (ASCO), University of Colorado Cancer Center researchers reported results of a Phase I trial of OMP-54F28 (FZD8-Fc), an investigational drug candidate discovered by OncoMed Pharmaceuticals targeting cancer stem cells (CSCs). The drug was generally well tolerated, and several of the 26 patients with advanced solid tumors experienced stable disease for greater than six months. Three trials...

Protein Discovery Could Boost Efficacy Of Bone Marrow Replacement Treatments
2014-05-01 03:38:51

University of California - San Diego Researchers at the University of California, San Diego School of Medicine report that a protein called beta-catenin plays a critical, and previously unappreciated, role in promoting recovery of stricken hematopoietic stem cells after radiation exposure. The findings, published in the May 1 issue of Genes and Development, provide a new understanding of how radiation impacts cellular and molecular processes, but perhaps more importantly, they suggest...

2014-02-28 13:39:01

Study helps explain chronic inflammation in autoimmunity and cancer Activation of beta-catenin, the primary mediator of the ubiquitous Wnt signaling pathway, alters the immune system in lasting and harmful ways, a team of Chicago-based researchers demonstrate in the February 26, 2014, issue of Science Translational Medicine. An increase in beta-catenin in certain types of T cells—a class of white blood cells—causes chronic inflammation in the intestine and colon, eventually leading...

2014-01-31 10:54:35

Scientists at Washington University School of Medicine in St. Louis have discovered what appears to be a potent stimulator of new bone growth. The finding could lead to new treatments for osteoporosis and other diseases that occur when the body doesn't make enough bone. Osteoporosis affects 55 percent of Americans age 50 and older. Of that age group, one in three women and one in 12 men are believed to have osteoporosis, a condition responsible for millions of fractures each year, mostly...

Stem Cell Research Cure Baldness
2013-12-20 09:45:37

redOrbit Staff & Wire Reports - Your Universe Online Regenerative medicine research conducted throughout this year at the University of Southern California (USC) could lead to new ways to counter baldness and receding hairlines using stem cells. USC Assistant Professor of Pathology Dr. Krzysztof Kobielak and his colleagues have published a trio of papers in the journals Stem Cells and the Proceedings of the National Academy of Sciences (PNAS) describing some of the biological...

2013-12-09 23:22:07

Generating new cardiac muscle from human embryonic stem cells (hESCs) and/or induced pluripotent stem cells (iPSC) could fulfill the demand for therapeutic applications and drug testing. The production of a similar population of these cells remains a major limitation, but in a study just published in STEM CELLS Translational Medicine, researchers now believe they have found a way to do this. Durham, NC (PRWEB) December 09, 2013 Generating new cardiac muscle from human embryonic stem cells...

2013-10-21 13:27:21

Scientists report in Nature they have found a novel and unexpected molecular switch that could become a key to slowing some of the ravages of getting older as it prompts blood stem cells to age. The study is expected to help in the search for therapeutic strategies to slow or reverse the aging process, and possibly rejuvenate these critically important stem cells (called hematopoietic stem cells, or HSCs), said scientists from Cincinnati Children's Hospital Medical Center and the...

2013-06-25 10:59:01

Gene mutations that cause cell signaling networks to go awry during embryonic development and lead to major birth defects may also cause subtle disruptions in the brain that contribute to psychiatric disorders such as schizophrenia, autism, and bipolar disorder, according to new research by UC San Francisco scientists. Over the past several years, researchers in the laboratory of psychiatrist Benjamin Cheyette, MD, PhD, have shown that mice with mutations in a gene called Dact1 are born...

2013-06-13 10:51:05

Researchers discover biochemical pathway that links nail growth to fingertip regeneration Mammals possess the remarkable ability to regenerate a lost fingertip, including the nail, nerves and even bone. In humans, an amputated fingertip can sprout back in as little as two months, a phenomenon that has remained poorly understood until now. In a paper published today in the journal Nature, researchers at NYU Langone Medical Center shed light on this rare regenerative power in mammals, using...

2013-06-03 13:30:35

Penn Medicine study highlights interplay between immune system and tissue regeneration Researchers in the Perelman School of Medicine at the University of Pennsylvania have determined the role of a key growth factor, found in skin cells of limited quantities in humans, which helps hair follicles form and regenerate during the wound healing process. When this growth factor, called Fgf9, was overexpressed in a mouse model, there was a two- to three-fold increase in the number of new hair...


Word of the Day
barratry
  • The offense of persistently instigating lawsuits, typically groundless ones.
  • An unlawful breach of duty on the part of a ship's master or crew resulting in injury to the ship's owner.
  • Sale or purchase of positions in church or state.
This word ultimately comes from the Old French word 'barater,' to cheat.
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