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Last updated on April 18, 2014 at 16:34 EDT

Latest Wnt signaling pathway Stories

Early Differentiation Of Higher Brain Structures Affected By Competing Pathways
2013-04-26 11:36:30

Georgia Institute of Technology Sand-dwelling and rock-dwelling cichlids living in East Africa's Lake Malawi share a nearly identical genome, but have very different personalities. The territorial rock-dwellers live in communities where social interactions are important, while the sand-dwellers are itinerant and less aggressive. Those behavioral differences likely arise from a complex region of the brain known as the telencephalon, which governs communication, emotion, movement and...

2013-04-12 15:53:17

Mount Sinai researchers present targets, treatments for prostate, colon, and ovarian cancer at the American Association for Cancer Research Annual Meeting Research on a soy-based treatment for colorectal cancer, a promising agent in ovarian cancer, and a new drug target for advanced prostate cancer was presented at the American Association for Cancer Research 2013 Annual Meeting. The meeting took place April 6-10, 2013 in Washington, DC. Natural Product From Soy May Be Effective in...

2013-03-22 09:34:32

Cells in the body need to be acutely aware of their surroundings. A signal from one direction may cause a cell to react in a very different way than if it had come from another direction. Unfortunately for researchers, such vital directional cues are lost when cells are removed from their natural environment to grow in an artificial broth of nutrients and growth factors. Now, researchers at the Stanford University School of Medicine and the Howard Hughes Medical Institute have devised a...

2013-02-26 11:54:12

Researchers at the Stanford University School of Medicine have identified a group of progenitor cells in the inner ear that can become the sensory hair cells and adjacent supporting cells that enable hearing. Studying these progenitor cells could someday lead to discoveries that help millions of Americans suffering from hearing loss due to damaged or impaired sensory hair cells. "It's well known that, in mammals, these specialized sensory cells don't regenerate after damage," said Alan...

2012-12-04 08:28:33

SAN DIEGO, Dec. 4, 2012 /PRNewswire/ -- Fate Therapeutics, Inc., a biopharmaceutical company engaged in the discovery and development of adult stem cell modulators, announced today several advancements in its goal to develop the first Wnt-protein therapeutic for regenerative medicine applications. After several years of systematically applied structural prediction, rational design and protein engineering, Fate Therapeutics has generated several proprietary Wnt-protein drug candidates...

2012-09-20 22:21:20

LAUSANNE, Switzerland, September 21, 2012 /PRNewswire/ -- Debiopharm Group(TM) (Debiopharm), a Swiss-based global biopharmaceutical group of companies with a focus on the development of prescription drugs that target unmet medical needs and companion diagnostics, today presented the 'JCA-Mauvernay Award' to Doctor Masanobu Oshima from Kanazawa University for his research on 'The Role of Inflammatory Responses in Gastric Cancer Development' and Doctor Shinji Tanaka from the Tokyo...

2012-07-19 02:37:48

The Cancer Genome Atlas generates genomic data for colon and rectal cancers that point to potential targets for treatment The pattern of genomic alterations in colon and rectal tissues is the same regardless of anatomic location or origin within the colon or the rectum, leading researchers to conclude that these two cancer types can be grouped as one, according to The Cancer Genome Atlas (TCGA) project's large-scale study of colon and rectal cancer tissue specimens. In multiple types of...

2012-07-17 12:20:03

- Partnership Based on Open Innovation That Leverages Eisai's Natural Product Chemistry-Based Drug Discovery Platform -Tokyo, July 17, 2012 - (JCN Newswire) - Eisai Co., Ltd. announced today that its U.S. subsidiary Eisai Inc. has entered into a research collaboration with U.S. biopharmaceutical company Verastem, Inc. for the generation of small molecule Wnt inhibitors that target cancer stem cells. Based on this agreement, Eisai will synthesize analogs of VS-507 (salinomycin) with the aim of...

2012-07-02 13:46:08

Analyzing circulating tumor cells reveals signaling pathway that may be essential to spread of deadly tumor Detailed analysis of genes expressed in circulating tumor cells (CTCs) -- cells that break off from solid tumors and travel through the bloodstream -- has identified a potential treatment target in metastatic pancreatic cancer. In a report that will appear in Nature and has received advance online publication, Massachusetts General Hospital (MGH) Cancer Center investigators describe...

Why Do Fat Cells Get Fat?
2012-06-25 13:47:23

Surprising finding about WNT signaling points to Sfrp5 as a potential target for anti-obesity drugs As the world fights obesity at the human level, scientists at the University of Michigan and their colleagues have made a surprising finding at the microscopic level that could help fuel that fight. Their work helps explain why fat-storing cells get fatter, and burn fat slower, as obesity sets in. If their findings from mice can be shown to apply to humans, they may provide a new target...