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Latest Wnt signaling pathway Stories

2012-07-02 13:46:08

Analyzing circulating tumor cells reveals signaling pathway that may be essential to spread of deadly tumor Detailed analysis of genes expressed in circulating tumor cells (CTCs) -- cells that break off from solid tumors and travel through the bloodstream -- has identified a potential treatment target in metastatic pancreatic cancer. In a report that will appear in Nature and has received advance online publication, Massachusetts General Hospital (MGH) Cancer Center investigators describe...

Why Do Fat Cells Get Fat?
2012-06-25 13:47:23

Surprising finding about WNT signaling points to Sfrp5 as a potential target for anti-obesity drugs As the world fights obesity at the human level, scientists at the University of Michigan and their colleagues have made a surprising finding at the microscopic level that could help fuel that fight. Their work helps explain why fat-storing cells get fatter, and burn fat slower, as obesity sets in. If their findings from mice can be shown to apply to humans, they may provide a new target...

2012-06-21 02:24:12

St. Jude Children's Research Hospital — Washington University Pediatric Cancer Genome Project lifts lid on the most aggressive subtype of medulloblastoma and finds genes that cooperate in tumor development Researchers studying the genetic roots of the most common malignant childhood brain tumor have discovered missteps in three of the four subtypes of the cancer that involve genes already targeted for drug development. The most significant gene alterations are linked to subtypes...

2012-05-31 01:31:03

Breast-cancer researchers at the University of Wisconsin-Madison have found that two related receptors in a robust signaling pathway must work together as a team to maintain normal activity in mammary stem cells. Mammary stem cells produce various kinds of breast cell types. They may also drive the development and growth of malignant breast tumors. Published recently in the Journal of Biological Chemistry, the research also suggests that a new signaling pathway may be involved, a...

2012-05-22 22:57:04

The impact and influence of thirty years of research into the Wnt/beta-catenin signaling pathway are highlighted in a special issue of The EMBO Journal. “Three decades of Wnt signalling” summarizes many of the crucial scientific developments that have taken place since the discovery of the first mammalian Wnt gene in 1982. The reviews also describe many of the crucial research findings that have established the pathway as one of the fundamental signal transduction mechanisms in...

2012-03-29 23:17:32

Proteins important in embryos found to change the adult brain Certain genes and proteins that promote growth and development of embryos also play a surprising role in sending chemical signals that help adults learn, remember, forget and perhaps become addicted, University of Utah biologists have discovered. "We found that these molecules and signaling pathways [named Wnt] do not retire after development of the organism, but have a new and surprising role in the adult. They are called...

2012-03-20 09:30:29

Patient biopsies reveal potential new target for therapy A genetic pathway previously known for its role in embryonic development and cancer has been identified as a target for systemic sclerosis, or scleroderma, therapy. The finding, discovered by a cross-disciplinary team led by John Varga, MD, John and Nancy Hughes Distinguished Professor of Rheumatology at Northwestern University Feinberg School of Medicine, was recently published in the journal Arthritis & Rheumatism. "We...

2012-03-15 22:50:56

Implications for treatment of birth defects, wounds, cancer The genetic pathway that regulates the way cells align themselves relative to each other has been found to act as a "stop sign" that signals organisms when to halt cell growth, according to new research published by biologists at the Center for Regenerative and Developmental Biology in Tufts University's School of Arts and Sciences. The research sheds light on one of the primary challenges to developing new ways to induce...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.