Latest Wnt signaling pathway Stories
Despite the promise associated with the therapeutic use of human stem cells, a complete understanding of the mechanisms that control the fundamental question of whether a stem cell becomes a specific cell type within the body or remains a stem cell has—until now—eluded scientists.
Researchers from the Massachusetts General Hospital (MGH) Cancer Center have identified a new potential strategy for treating colon tumors driven by mutations in the KRAS gene, which usually resist both conventional and targeted treatments.
Baylor College of Medicine researchers presented new data regarding breast cancer stem cells, the unique subset of breast cancer cells that are capable of initiating tumor growth and are relatively resistant to chemo and radiotherapies.
Damage to podocytes -- a specialized type of epithelial cell in the kidney -- occurs in more than 90 percent of all chronic kidney disease.
Scientists at Weill Cornell Medical College used genetic methods to successfully repair cleft lips in mice embryos specially engineered for the study of cleft lip and cleft palate.
New research in Developmental Cell suggests that increasing expression of certain developmental genes at precise times in the uterus might improve pregnancy rates from in vitro fertilization-embryo transfers (IVF-ET), which remain low at around 30 percent.
In principle, stem cells offer scientists the opportunity to create specific cell types—such as nerve or heart cells—to replace tissues damaged by age or disease.
The embryonic enzyme pyruvate kinase M2 (PKM2) has a well-established role in metabolism and is highly expressed in human cancers.
Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways.
Researchers from the NYU Cancer Institute, an NCI-designated cancer center at NYU Langone Medical Center, have identified a cell cycle-regulated mechanism behind the transformation of normal cells into cancerous cells.
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