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Latest Wnt signaling pathway Stories

2012-03-02 01:29:33

Finding promises to streamline creation of therapeutic cells Despite the promise associated with the therapeutic use of human stem cells, a complete understanding of the mechanisms that control the fundamental question of whether a stem cell becomes a specific cell type within the body or remains a stem cell has–until now–eluded scientists. A University of Georgia study published in the March 2 edition of the journal Cell Stem Cell, however, creates the first ever blueprint...

2012-02-16 18:16:47

Better understanding of cancer-promoting pathway may lead to new strategy for treatment-resistant tumors Researchers from the Massachusetts General Hospital (MGH) Cancer Center have identified a new potential strategy for treating colon tumors driven by mutations in the KRAS gene, which usually resist both conventional and targeted treatments. In a paper appearing in the Feb. 17 issue of Cell, the team reports that targeting a later step in the pathway leading from KRAS activation to tumor...

2011-12-12 16:09:54

Baylor College of Medicine researchers presented new data regarding breast cancer stem cells, the unique subset of breast cancer cells that are capable of initiating tumor growth and are relatively resistant to chemo and radiotherapies, today at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium. The conference is co-sponsored by BCM, the American Association of Cancer Research and the Cancer Therapy and Research Center at the University of Texas Health Science Center in San Antonio....

2011-12-05 13:01:24

Damage to podocytes -- a specialized type of epithelial cell in the kidney -- occurs in more than 90 percent of all chronic kidney disease. Now researchers at the Stanford University School of Medicine have uncovered an unexpected pathway that reveals for the first time how these cells may regenerate and renew themselves during normal kidney function. This finding is an important step toward one day therapeutically coaxing the cells to divide, which could be used to treat people with...

2011-11-28 23:15:53

Weill Cornell researchers report development and use of new mouse model that could show the way to new treatments and prevention strategies for cleft lip and cleft palate in humans Scientists at Weill Cornell Medical College used genetic methods to successfully repair cleft lips in mice embryos specially engineered for the study of cleft lip and cleft palate. The research breakthrough may show the way to prevent or treat the conditions in humans. Cleft lip and cleft palate are among the...

2011-11-18 02:50:45

New research in Developmental Cell suggests that increasing expression of certain developmental genes at precise times in the uterus might improve pregnancy rates from in vitro fertilization-embryo transfers (IVF-ET), which remain low at around 30 percent. Conducted by researchers at Cincinnati Children's Hospital Medical Center, the study is to be published online by the journal on Nov. 17. Researchers point to the genes Msx1 and Msx2 — which play integral roles in organ...

2011-11-14 23:38:14

In principle, stem cells offer scientists the opportunity to create specific cell types–such as nerve or heart cells–to replace tissues damaged by age or disease. In reality, coaxing stem cells to become the desired cell type can be challenging, to say the least. In a paper published this week in the journal Proceedings of the National Academy of Sciences, however, scientists at the University of Georgia describe a method that–in a single step–directs...

2011-11-07 13:03:26

Findings point to possible personalized brain tumor therapy with Src inhibitors The embryonic enzyme pyruvate kinase M2 (PKM2) has a well-established role in metabolism and is highly expressed in human cancers. Now, a team led by researchers at the University of Texas MD Anderson Cancer Center reports in advance online publication of the journal Nature that PKM2 has important non-metabolic functions in cancer formation. "Our research shows that although PKM2 plays an important role in...

2011-10-27 15:37:17

FINDINGS: Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways. In this way, signaling pathways are targeted to genes that are most relevant to each cell type and tailor gene expression to control cell state, growth, differentiation, and death. RELEVANCE: When signaling pathways operate properly, a cell receives instructions from its neighbors and the environment that tweak gene expression and control the...

2011-10-24 09:25:24

CK1 protein in cancer cells identified as possible future therapeutic target Researchers from the NYU Cancer Institute, an NCI-designated cancer center at NYU Langone Medical Center, have identified a cell cycle-regulated mechanism behind the transformation of normal cells into cancerous cells. The study shows the significant role that protein networks can play in a cell leading to the development of cancer. The study results, published in the October 21 issue of the journal Molecular...


Word of the Day
penuche
  • A fudgelike confection of brown sugar, cream or milk, and chopped nuts.
'Penuche' is a variant of 'panocha,' a coarse grade of sugar made in Mexico. 'Panocha' probably comes from the Spanish 'panoja, panocha,' ear of grain.
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