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Latest Wnt signaling pathway Stories

2011-10-24 09:07:16

Previously unknown role of FoxM1 is crucial to regulation of brain tumor stem cells Two previously unassociated proteins known to be overly active in a variety of cancers bind together to ignite and sustain malignant brain tumors, a research team led by scientists at The University of Texas MD Anderson Cancer Center reports this week in the journal Cancer Cell. This research is the first to connect FoxM1 to a molecular signaling cascade that regulates normal neural stem cells, said...

2011-09-29 23:14:11

Study findings indicate a key step in the generation of white matter and understanding developmental disabilities Through the identification of a gene's impact on a signaling pathway, scientists at Children's National Medical Center continue to make progress in understanding the mechanics of a key brain developmental process: growth and repair of white matter, known as myelination. The study, published online in the September 2011 online edition of The Journal of Neuroscience, identified...

2011-09-21 19:09:39

Brain disorder accounts for 1 in 4 cases No cure exists for frontotemporal dementia, which strikes between the ages of 40 and 64 and accounts for at least one in four cases of early-onset dementia. Caused by the death of cells in the front and sides of the brain, the disease can lead to dramatic changes in a patient's personality and behavior, including the loss of the ability to communicate. Now UCLA scientists have discovered that a key signaling pathway plays an important role in the...

Scientists Successfully Expand Bone Marrow-derived Stem Cells In Culture
2011-09-16 06:54:07

  All stem cells–regardless of their source–share the remarkable capability to replenish themselves by undergoing self-renewal. Yet, so far, efforts to grow and expand scarce hematopoietic (or blood-forming) stem cells in culture for therapeutic applications have been met with limited success. Now, researchers at the Stowers Institute for Medical Research teased apart the molecular mechanisms enabling stem cell renewal in hematopoietic stem cells isolated from mice and...

2011-09-01 17:08:32

Salk scientists discover a highly conserved mechanism governing brain development If you think today's political rhetoric is overheated, imagine what goes on inside a vertebrate embryo. There, two armies whose agendas are poles apart, engage in a battle with consequences much more dire than whether the economy will recover---- they are battling for whether you (or frogs or chickens) will have a forebrain. In a study published in the August 19 online edition of Genes & Development,...

2011-07-20 17:21:43

A team of researchers from the University of Utah and Brigham Young University has developed a mouse model of focal dermal hypoplasia, a rare human birth defect that causes serious skin abnormalities and other medical problems. A team of researchers from the University of Utah and Brigham Young University has developed a mouse model of focal dermal hypoplasia, a rare human birth defect that causes serious skin abnormalities and other medical problems. This animal model not only provides...

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2011-06-15 09:15:00

According to a new study published in the journal Cell, Wnt signaling, already known to control many biological processes, between hair follicles and melanocyte stem cells can determine hair pigmentation. The research at NYU Langone Medical Center was led by Mayumi Ito, PhD, assistant professor at the Ronald O. Pereleman Department of Dermatology at NYU. "We have known for decades that hair follicle stem cells and pigment-producing melanocyte cells collaborate to produce colored hair, but...

2011-06-09 15:00:55

Mice born to mothers who are fed a diet supplemented with B vitamins are less likely to develop intestinal tumors, report scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University. Previous research in humans and mice suggests that B vitamins, particularly folate, play a role in the prevention of colorectal cancer. Using a mouse model of naturally occurring colorectal cancer, the USDA HNRCA scientists examined whether a mothers' B vitamin...

2011-05-31 12:17:16

Scientists identify in the journal Nature a new molecular pathway used to suppress blood vessel branching in the developing retina "“ a finding with potential therapeutic value for fighting diseases of the retina and a variety of cancers. Researchers report that myeloid cells, blood cells involved in the immune system, use this molecular pathway to guide blood vessel patterning in the retina. Furthermore, in the same study researchers were able to reverse this pathway to accelerate the...

2011-05-29 12:00:00

CINCINNATI, May 29, 2011 /PRNewswire-USNewswire/ -- Scientists identify in the journal Nature a new molecular pathway used to suppress blood vessel branching in the developing retina - a finding with potential therapeutic value for fighting diseases of the retina and a variety of cancers. (Logo: http://photos.prnewswire.com/prnh/20110406/MM79025LOGO) Researchers report that myeloid cells, blood cells involved in the immune system, use this molecular pathway to guide blood vessel...


Word of the Day
endocarp
  • The hard inner (usually woody) layer of the pericarp of some fruits (as peaches or plums or cherries or olives) that contains the seed.
This word comes from the Greek 'endon,' in, within, plus the Greek 'karpos', fruit.
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