Quantcast
Last updated on April 24, 2014 at 5:30 EDT

Latest Wnt signaling pathway Stories

2011-05-16 19:24:39

Worm with abundant ability to regenerate relies on ancient gene to make decisions Most people don't think worms are cool. But the tiny flatworm that Northwestern University scientist Christian Petersen studies can do something very cool indeed: it can regenerate itself from nearly every imaginable injury, including decapitation. When cut in half, it becomes two worms. This amazing ability of the planarian flatworm to regenerate its entire body from a small wedge of tissue has fascinated...

2011-05-12 22:18:51

A seldom-studied gene known as notum plays a key role in the planarian's regeneration decision-making process, according to Whitehead Institute scientists. Protein from this gene determines whether a head or tail will regrow at appropriate amputation sites. Since the late 1800s, scientists have been fascinated by the planarian's amazing ability to regenerate its entire body from a small wedge of tissue. Whitehead Member Peter Reddien and former postdoctoral fellow Christian Petersen recently...

2011-04-28 07:30:00

REDWOOD CITY, Calif., April 28, 2011 /PRNewswire/ -- OncoMed Pharmaceuticals, Inc., a company developing novel therapeutics that target cancer stem cells or tumor-initiating cells, today announced that the FDA has accepted an IND filing for OMP-18R5, which allows OncoMed to commence Phase 1 clinical testing. OMP-18R5 is a monoclonal antibody that binds selected receptors in the Wnt signaling pathway and is the first antibody to specifically block these targets to enter human studies....

2011-04-27 01:55:54

Among obese patients, activation of the protein biomarker CTNNB1 was associated with better colorectal cancer-specific survival and overall survival, whereas post-diagnosis physical activity was associated with better colorectal cancer-specific survival among patients negative for CTNNB1, according to a study in the April 27 issue of JAMA. Activation of the WNT signaling pathway (a network of proteins known for their roles in cancer) and cadherin-associated protein beta-1 (CTNNB1;...

2011-04-21 07:30:00

REDWOOD CITY, Calif., April 21, 2011 /PRNewswire/ -- OncoMed Pharmaceuticals, Inc., a company developing novel therapeutics targeting cancer stem cells, today announced it has expanded its collaboration with Bayer HealthCare. Bayer's U.S. affiliate will manufacture clinical supplies of a second Wnt inhibitor in the alliance. Bayer will manufacture the bulk drug substance at its Berkeley, California clinical manufacturing center to support Phase 1 clinical testing planned to commence...

2011-04-13 21:05:19

NYU School of Medicine researchers find molecules block a crucial cell pathway Researchers from the Cancer Institute at NYU Langone Medical Center have identified three novel small molecules that interrupt a crucial cellular communication pathway that regulates many aspects of development and cancer. The finding, published in the April 12, 2011 issue of the Proceedings of the National Academy of Sciences and featured on its cover, could provide the basis for innovative therapies for...

2011-04-05 21:18:16

Researchers say the discovery could offer a new screening and therapeutic strategies Most women are infected with human papillomavirus (HPV), which can cause cervical cancer - yet few develop the cancer. Now researchers at Georgetown Lombardi Comprehensive Cancer Center, a part of Georgetown University Medical Center, believe they have found the missing link explaining why: activation of the beta-catenin oncogene. At the American Association for Cancer Research (AACR) 102nd Annual Meeting...

2011-03-14 16:19:56

New research shows that the Wnt receptor Frizzled-9 (Fzd9) promotes bone formation, providing a potential new target for the treatment of osteoporosis. The study appears online on March 14 in The Journal of Cell Biology (www.jcb.org). Adult bones are maintained by a balance of bone-forming osteoblasts and bone-resorbing osteoclasts. Although Wnt signaling affects this balance in mice and humans, the Wnt receptors involved remain unknown. A team of researchers led by Thorsten Schinke found...

2011-02-14 16:26:20

Neurobiologists at UC San Diego have discovered new ways by which nerves are guided to grow in highly directed ways to wire the brain during embryonic development. Their finding, detailed in a paper in the February 15 issue of the journal Developmental Cell, provides a critical piece of understanding to the longstanding puzzle of how the human brain wires itself into the complex networks that underlie our behavior. The discovery concerns the movements of a highly sensitive and motile...

2010-12-17 13:02:35

Comprehensive study of medulloblastoma suggests targeted drugs may be especially effective in children Pediatric cancer researchers at The Children's Hospital of Philadelphia contributed important expertise to a new landmark study of medulloblastoma, a type of brain tumor typically found in children. The large multicenter study defines the genetic landscape of this cancer, and holds intriguing clues to gene changes on signaling pathways that may become fruitful targets for future therapies....