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Latest Wnt signaling pathway Stories

2011-02-14 16:26:20

Neurobiologists at UC San Diego have discovered new ways by which nerves are guided to grow in highly directed ways to wire the brain during embryonic development. Their finding, detailed in a paper in the February 15 issue of the journal Developmental Cell, provides a critical piece of understanding to the longstanding puzzle of how the human brain wires itself into the complex networks that underlie our behavior. The discovery concerns the movements of a highly sensitive and motile...

2010-12-17 13:02:35

Comprehensive study of medulloblastoma suggests targeted drugs may be especially effective in children Pediatric cancer researchers at The Children's Hospital of Philadelphia contributed important expertise to a new landmark study of medulloblastoma, a type of brain tumor typically found in children. The large multicenter study defines the genetic landscape of this cancer, and holds intriguing clues to gene changes on signaling pathways that may become fruitful targets for future therapies....

2010-12-08 22:14:33

International effort led by St. Jude Children's Research Hospital scientists is expected to fuel development of targeted therapies and aid the search for unique combinations of cells and mutations that lead to other cancers Investigators have demonstrated for the first time that the most common malignant childhood brain tumor, medulloblastoma, is actually several different diseases, each arising from distinct cells destined to become different structures. The breakthrough is expected to...

2010-11-19 13:43:42

An old pinworm medicine is a new lead in the search for compounds that block a signaling pathway implicated in colon cancer. The findings, reported by Vanderbilt University Medical Center researchers in the November issue of Nature Chemical Biology, suggest a fresh approach for developing therapeutics that target the pathway. More than 90 percent of sporadic (non-inherited) colon cancers "” the second deadliest type of cancer in the developed world "” are caused by mutations that...

2010-09-20 22:36:54

St. Jude research results help build a foundation for the next generation of therapies using cell-replacement strategies to restore vision lost to the retinal degeneration associated with glaucoma, diabetic retinopathy and age-related macular degeneration New research led by St. Jude Children's Research Hospital investigators adds to evidence that the Six3 gene functions like a doorman in the developing brain and visual system, safeguarding the future retina by keeping the region where the...

2010-09-14 10:00:00

SAN DIEGO, Sept. 14 /PRNewswire/ -- Wintherix, LLC, a privately held biotechnology company focusing on bone healing and regenerative medicine, today announced that WX04554, a potent small molecule activator of the Wnt pathway, has been designated as a lead drug for clinical development in bone healing and repair indications. Pre-clinical studies indicate that this class of small molecules potently activates the Wnt pathway and causes bones to heal and become stronger by forcing stem cells...

2010-09-14 00:59:05

Hutchinson-Gilford Progeria Syndrome (HGPS or progeria) is a rare genetic disease that causes young children to develop symptoms associated with advanced age, such as baldness, wrinkles, osteoporosis and cardiovascular disease. Now, a study published by Cell Press in the September 14th issue of the journal Developmental Cell uses a mouse model to shed light on progeria, and perhaps also on the normal aging process. Progeria is caused by a mutation in the gene for lamin A that leads to...

2010-08-09 10:00:00

SAN DIEGO, Aug. 9 /PRNewswire/ -- Epitherix, LLC, a privately held company focused on the discovery and development of novel Wnt pathway small molecule inhibitors for epithelial and leukemic cancers, today announced that it has identified multiple chemical scaffolds that are potent and selective against colorectal carcinoma. "We're very encouraged by our in vitro and in vivo data, especially considering the difficulty in drugging this pathway to date," said Dr. Osman Kibar, CEO of...

2010-07-15 02:43:36

Scientists are making progress towards a better understanding of the neuropathology associated with debilitating psychiatric illnesses like bipolar disorder and schizophrenia. New research, published by Cell Press in the July 15 issue of the journal Neuron, reveals mechanisms that connect a known psychiatric risk gene to disruptions in brain cell proliferation and migration during development. A research group led by Dr. Li-Huei Tsai from the Massachusetts Institute of Technology had recently...

2010-06-22 01:59:57

The APC protein serves as the colon's guardian, keeping tumors at bay. Now researchers reveal a new function for the protein: helping to renovate the cytoskeleton by triggering actin assembly. The result suggests a second way that mutations in APC could lead to cancer. The study appears online on June 21 in the Journal of Cell Biology (www.jcb.org). A faulty APC gene occurs in more than 80% of colon cancers and is one of the early "gateway" mutations leading to abnormal growth. Researchers...


Word of the Day
tessitura
  • The prevailing range of a vocal or instrumental part, within which most of the tones lie.
This word is Italian in origin and comes from the Latin 'textura,' web, structure.