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Last updated on April 16, 2014 at 5:49 EDT

Latest Wnt signaling pathway Stories

2010-05-28 13:25:14

A Florida State University College of Medicine researcher has discovered a new interaction between a cell signaling system and a specific gene that may be the cause of B-cell lymphoma. The finding suggests a similar interaction could be occurring during the development of other types of cancer, leading to further understanding of how cancer works "” and how it might be stopped. Yoichi Kato, an assistant professor in the Department of Biomedical Sciences, and his lab team found that the...

2010-04-07 13:44:13

The vivid colors and designs animals use to interact with their environments have awed and inspired since before people learned to draw on the cave wall. But how different creatures in the animal kingdom "” from colorful birds and reef fish to butterflies and snakes "” make and deploy their artful designs is one of nature's deepest secrets. Now, however, a team of researchers from the Howard Hughes Medical Institute at the University of Wisconsin-Madison has exposed the fine...

2010-03-26 09:06:51

Study reveals possible new strategy in eradicating chemo-resistant leukemia stem cells About 40 percent of children and up to 70 percent of adults in remission from acute myelogenous leukemia (AML) will have a relapse. In recent years, doctors have come to believe that this is due to leukemia stem cells, endlessly replicating cancer cells that generate the immature blood cells characteristic of leukemia and are resistant to typical cancer treatments. Now, researchers at Children's Hospital...

2010-02-15 14:29:38

Scientists have discovered a molecular pathway that works through the immune system to regenerate damaged kidney tissues and may lead to new therapies for repairing injury in a number of organs systems. The findings, reported in this week's Proceedings of the National Academy of Sciences (PNAS), come from collaborative research led by Cincinnati Children's Hospital Medical Center and the Brigham & Women's Hospital of Harvard Medical School. The study may have significant medical...

2009-12-16 12:19:29

Tissue-specific genes, thought to be dormant or not marked for activation in embryonic stem cells, are indeed marked by transcription factors, with proper marking potentially crucial for the function of tissues derived from stem cells. The finding in the study by researchers at the Broad Stem Cell Research Center involves a class of genes whose properties previously were thought to be unimportant for stem cell function. Most research has instead focused on genes that regulate a pluripotency...

2009-11-25 14:59:29

M. D. Anderson-led team connects the dots among three distinct components of cancer development, potentially pointing the way to new therapeutic strategies Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers from The University of Texas M. D. Anderson Cancer Center report in the Nov. 25 issue of Molecular Cell. This newly...

2009-11-15 12:07:52

Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors. "We are very excited about these findings," says Vladimir Spiegelman, an associate professor of dermatology. "Drugs could be developed to block this mechanism and prevent colorectal cancer, which affects millions of people worldwide." The research will appear in...

2009-09-16 13:04:00

HEIDELBERG, Germany, September 16 /PRNewswire/ -- - Integrated Chemical Genetics and Proteomics Approach Identifies new Potential Drug Targets in Wnt Pathway Cellzome announces today, the publication entitled "Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling"** is now available online in Nature. The paper describes how Cellzome's quantitative chemical proteomics platform was used to identify a small molecule which plays a critical role in the regulation...

2009-09-14 15:37:11

Amputations trigger a molecular response that determines if a head or tail will be regrown in planaria, a flatworm commonly studied for its regenerative capabilities. Until now, no molecular connection between wounding and the decision to regenerate either a head or tail in planaria had been identified. Whitehead Institute scientists report this finding in the September 15-28 issue of PNAS Early Edition. Regeneration is the regrowth of part of an organism's body after it has been damaged or...

2009-09-08 15:43:38

Researchers at the Carnegie Institution's Department of Plant Biology have discovered a key missing link in the so-called signaling pathway for plant steroid hormones (brassinosteroids). Many important signaling pathways are relays of molecules that start at the cell surface and cascade to the nucleus to regulate genes. This discovery marks the first such pathway in plants for which all the steps of the relay have been identified. Since this pathway shares many similarities with pathways in...