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Scientists Hunt Down Origin Of Huntington's Disease In The Brain
2014-04-29 17:24:09

Elaine Schmidt, University of California - Los Angeles Health Sciences The gene mutation that causes Huntington's disease appears in every cell in the body, yet kills only two types of brain cells. Why? UCLA scientists used a unique approach to switch the gene off in individual brain regions and zero in on those that play a role in causing the disease in mice. Published in the April 28 online edition of Nature Medicine, the research sheds light on where Huntington's starts in the...

2009-12-25 22:12:54

In Huntington's disease, a mutated protein in the body becomes toxic to brain cells. Recent studies have demonstrated that a small region adjacent to the mutated segment plays a major role in the toxicity. Two new studies supported by the National Institutes of Health show that very slight changes to this region can eliminate signs of Huntington's disease in mice. Researchers do not fully understand why the protein (called mutant huntingtin) is toxic, but one clue is that it accumulates in...

2009-12-25 22:04:50

Finding suggests new approach for treating devastating genetic disorder UCLA scientists have identified a molecular switch that prevents Huntington's disease from developing in mice. Published in the Dec. 24 edition of the journal Neuron, the discovery suggests a new approach to treating the genetic disorder, which ultimately leads to death in as little as 10 years. Affecting one out of every 10,000 Americans, Huntington's progressively deprives patients of their ability to walk, speak, think...

2009-12-23 16:50:18

Scientists have identified a key molecular switch that may drive the onset of Huntington's disease (HD), an incurable neurodegenerative disorder that leads to severe disruptions in muscle coordination and cognitive function. The research, published by Cell Press in the December 24 issue of the journal Neuron, enhances the understanding of HD pathogenesis and may direct new strategies for treating this devastating brain disease. HD is caused by an abnormally lengthy repeating stretch of the...


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bellycheer
  • Good cheer; viands.
  • To revel; to feast.
The word 'bellycheer' may come from 'belle cheer', "good cheer".
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