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Last updated on April 17, 2014 at 21:23 EDT

Latest Z. Josh Huang Stories

2012-11-23 10:56:34

They show how embryonic origin and timing influence cell specification and network integration The cerebral cortex of the human brain has been called "the crowning achievement of evolution." Ironically, it is so complex that even our greatest minds and most sophisticated science are only now beginning to understand how it organizes itself in early development, and how its many cell types function together as circuits. A major step toward this great goal in neuroscience has been taken by...

2012-01-04 08:56:59

Quite early in its development, the mammalian brain has all the raw materials on hand to forge complex neural networks. But forming the connections that make these intricate networks so exquisitely functional is a process that occurs one synapse at a time. An important question for neuroscience has been: how exactly do stable synapses form? How do nerve cells of particular types know which of their cortical neighbors to "synapse" with, and which to leave out of their emerging networks?...

2011-09-21 19:44:41

20 mouse lines provide views of cortical GABA neurons not previously possible A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has succeeded in creating what amounts to a GPS system for locating and tracking a vital class of brain cells that until now has eluded comprehensive identification, particularly in living animals. The cells in question are the class of neurons that release the neurotransmitter called GABA (gamma aminobutyric acid). GABA neurons function to...

2010-12-21 15:58:34

How GABA transmission regulates synaptic adhesion at developing inhibitory synapses Newly published research led by Professor Z. Josh Huang, Ph.D., of Cold Spring Harbor Laboratory (CSHL) sheds important new light on how neurons in the developing brain make connections with one another. This activity, called synapse validation, is at the heart of the process by which neural circuits self-assemble, and is directly implicated in pathology that gives rise to devastating neurodevelopmental...