Cell Therapy for Parkinson’s Disease
(Ivanhoe Newswire) — Parkinson’s disease is a disorder of the brain that leads to shaking, difficulty with walking, movement, and coordination. With 50,000 new cases reported every year it is one of the most common nervous system disorders of the elderly. Researchers are attempting to develop stem cell therapy to replace cells causing this disease.
In Parkinson’s disease, the loss of dopamine-producing cells in the midbrain causes well-characterized motor symptoms. Though embryonic stem cells could potentially be used to replace dopaminergic (DA) neurons in Parkinson’s disease patients, such cell therapy options must still overcome technical obstacles before the approach is ready for the clinic. Embryonic stem cell-based transplantation regimens carry a risk of introducing inappropriate cells or even cancer-prone cells.
To develop cell purification strategies to minimize these risks, Dr. Lorenza Studer and colleagues at Memorial Sloan Kettering Cancer Center in New York developed three different mouse lines to label dopaminergic neurons at early, mid, and late stages of differentiation.
Their data suggest that mouse embryonic stem cells induced to the mid-stage of neuronal differentiation are best suited for transplantation to replace dopaminergic neurons.
Further, their work identified new genes associated with each stage of neuronal differentiation. Their results in the mouse model system help define the differentiation stage and specific attributes of embryonic stem cell-derived, dopamine-generating cells that hold promise for cell therapy applications.
Source: Journal of Clinical Investigation, July 2012