(Ivanhoe Newswire) — Tired of the pain, pills and joint swelling? A team of researchers in North Carolina discovered that lubricin, a synovial fluid glycoprotein, may treat or prevent joint disease.
Osteoarthritis is the most common form of arthritis, the degenerative joint disease. It mostly affects cartilage, the slippery tissue that covers the ends of bones where they meet to form a joint, and allows bones to glide over one another with limited friction and wear. Osteoarthritis causes cartilage to be broken down through a vicious cycle of mechanical and metabolic factors, and mechanical wear of cartilage is widely believed to contribute to this process. Eventually, the bones under the cartilage rub together, which can cause a tremendous amount of pain, swelling, and loss of motion at the joint.
Many studies have examined cartilage friction and lubrication with the goal of understanding cartilage wear prevention. Very few studies have focused on measuring wear directly, though, and until now no other studies have directly assessed the effects of synovial fluid constituents in mediating wear.
“We measured the effect of the synovial fluid protein lubricin on cartilage wear,” Stefan Zauscher, an associate professor of mechanical engineering and material science, as well as biomedical engineering, at Duke University in Durham, N.C., was quoted as saying.
“Our measurements were performed at the surface level using an atomic force microscope with pressures and sliding speeds comparable to those seen in joints. The measurements show a direct link between lubricin in solution and reduction of cartilage wear,” Zauscher stated.
This indicates that lubricin is important for cartilage preservation physiologically, which may have important implications for treating or preventing joint disease in the future.
SOURCE: Lubricin Reduces Microscale Cartilage Wear, October 2010