Our Brain Senses A Fall Before Our Muscles React

April Flowers for redOrbit.com – Your Universe Online

When you stumble and fall, your brain catches on very quickly, but it feels like your muscles aren’t doing anything to stop it – and it always occurs in front of a million people, or at least that one person you want to impress the most.

A fall for a young person is merely embarrassing. For an elderly person, however, falling can be a life threatening situation. Approximately 80 percent of the elderly who break a hip die within a year.

A new study from the University of Michigan suggests the critical window of time between when the brain senses a fall and when the muscles respond may help explain why so many older people suffer these serious falls – which could add a great deal to prevention efforts.

A research team from the U-M School of Kinesiology has developed a new method for looking at the electrical response in the brain before and during a fall by using an electroencephalogram (EEG).

The findings, reported in the Journal of Neurophysiology, revealed many areas of the brain sense and respond to a fall, but that happens well before the muscles react. Daniel Ferris, professor of Kinesiology, likened the study method to recording an orchestra with many microphones and then teasing out the sounds of specific instruments. The research team used the EEG to measure electrical activity in different regions of the brain.

“We’re using an EEG in a way others don’t, to look at what’s going on inside the brain,” said Ferris. “We were able to determine what parts of the brain first identify when you are losing your balance during walking.”

Healthy young subjects walked on a balance beam mounted to a treadmill with electrodes attached to their scalps. To avoid injury, when a participant lost their balance and fell from the beam, they simply continued walking on the moving treadmill.

The research team used a method known as independent components analysis to separate and visualize the electrical activity in different regions of the brain. According to their findings, people sense the start of a fall much better with both feet on the ground. People aren’t as sure of their stability on one foot, but two grounded feet make it easier to determine where the ground is relative to the body.

The team was surprised to find so many regions of the brain activate during a fall. They also found it surprising the brain recognizes a loss of balance as quickly as it does.

The scientists suggest further studies that compare the elderly with younger subjects could help determine if the elderly sense falls too late. If this is the case, pharmaceuticals might help them regain their balance. If, instead, it is a simple motor problem such as muscles not responding properly, then strengthening exercises could help.

The Ferris lab is continuing research under the same grant, looking to separate sensory and motor contributions to brain activity during walking.

Engineers Present Battery-Less Technology For Wireless Gadgets

[ Watch The Video: Researchers Bring The Internet Of Things One Step Closer To Reality ]

Michael Harper for redOrbit.com – Your Universe Online

In our hyper-connected world, we create a good deal of digital waste. Cell towers, TV towers and even Wi-Fi hotspots constantly deliver wireless communications to a host of devices. But what of all those signals and waves that go unused?

Engineers from the University of Washington want to recycle these waves, in a sense, and use them to power new types of sensors and wireless devices. The result would be a new technology that operates without the use of batteries.

The U of W engineers are set to present their research at the annual Association for Computing Machinery’s Special Interest Group on Data Communication 2013 conference in Hong Kong.

They have dubbed the new technology “Ambient Backscatter,” and it works by re-purposing the signals which are already coursing through the air. In a demonstration video, the team shows off the interaction between two tiny circuit boards decked with a single antenna and lacking any type of batteries. As one person interacts with the device, in this case pushing a sequence of buttons and swiping their finger on a touch display, the other device receives this interaction, blinking an LED light in confirmation.

“Our devices form a network out of thin air,” said co-author Joshua Smith, an associate professor of computer science and engineering and of electrical engineering at the University of Washington. “You can reflect these signals slightly to create a Morse code of communication between battery-free devices.”

The team now envisions a future where small sensors can be placed on all manner of items, objects and even embedded within walls to create “an Internet of things.” Since these sensors only borrow radio signals from other devices and towers, they’ll never need batteries and, therefore, will require no human interaction to speak of.

In their demonstration video, the team shows how this technology could be used in a number of ways, including facilitating a money transfer between two people. One circuit board device was registered with a certain amount of money, then forwarded these imaginary funds to another circuit board. The entire transaction was conducted without wires and without batteries.

The team also suggests that Ambient Backscatter tags could be placed on objects like keys, so that when a person walks too far away from their keys with their cell phone, they could receive an alert to let them know where their keys are. They also suggest putting these sensors in walls to measure all sorts of activity, such as fluctuations in temperature or when a homeowner arrives at home.

The University of Washington students tested these devices all over Seattle in locations ranging between half a mile and 6.5 miles away from TV towers. When the wireless and battery-less circuit boards communicated with one another, they transmitted data at a speed of about 1 kilobit per second when 2.5 feet apart and outdoors. The devices transmitted data at the same speed when 1.5 feet away indoors. This speed is sufficient for reading sensors or sending a text message, say the researchers.

Though this new technology allows for battery-free devices, the team say it could also be built into smartphones and other devices with batteries to extend their life. When the battery dies on a smartphone, for instance, this technology could provide enough power to send and receive text messages and communicate with sensors.

All-Terrain ‘Parkour Robot’ RHex Capable Of Jumping, Climbing

[ Watch the Video: University of Pennsylvania Unveils Acrobatic Robot ]

redOrbit Staff & Wire Reports – Your Universe Online

Researchers from the University of Pennsylvania (Penn) have created a new all-terrain, six-legged walking robot that has been specially designed with jumping and climbing capabilities that could help it complete military reconnaissance, rescue or supply transportation missions.

The robot is named RHex (pronounced “Rex” and short for “robot hexapod”), and according to its creators at the university’s Kodlab facility, it is a “biologically inspired hexapedal robot” that has been affectionately dubbed the “parkour robot.” The researchers have been using human free-runners to discover new ways for the robot to manipulate itself in order to overcome a variety of different obstacles.

In videos demonstrating its capabilities – which are available in both regular and “extended cut” versions – RHex is shown walking across multiple different types of terrain, flipping itself over, climbing on top of rocks and completing various other tasks.

RHex was first developed as part of a DARPA-funded collaboration more than a decade ago between several universities, in which experts began to ponder what it would take for robots to be able to traverse offroad terrain as well as animals do, according to Keith Collins of the Associated Press (AP).

[ Watch the Video: University of Pennsylvania Unveils Acrobatic Robot – Extended ]

“You look at any machine that’s been built today, and almost any animal that you can imagine will outperform that machine,” Penn electrical and systems engineering professor Daniel Koditschek, who has been involved in the project since day one, told Collins. He and graduate student Aaron Johnson are behind the latest version of RHex.

Johnson and Koditschek are also teaming up on an upgraded, lighter and more agile model for RHex. This enhanced robot, which would be known as XRL (X-RHex Lite), would be constructed from carbon fiber and would be capable of executing “double jumps, flips, and, through a combination of moves, even pull-ups,” the researchers said.

It would also be able to overcome taller obstacles by launching itself vertically, hooking its front legs on the edge of the object it is trying to overcome, and then dragging its chassis up and over, they added. The Kod*lab team reports that they have completed successful demonstrations of this maneuver multiple times under laboratory conditions.

Past versions of the robot included the original, known as Research RHex; EduBot, which was a version for use in classrooms; SandBot, which was an offshoot of EduBot used by researchers at Georgia Tech to study traveling over sand; and Desert RHex, a modified version of Research RHex deployed during desert terrain tests in the Mojave Desert in 2009. A commercial version, known as the Rugged RHex, is produced by Boston Dynamics, Inc.

Back on July 30, Johnson told CNET’s Amanda Kooser that the ultimate goal of the project is the development of “a robot that can go anywhere, even over terrain that might be broken and uneven.” He added that his team’s most recent advances on the RHex project “greatly expand the range of what this machine is capable of, as it can now jump onto or across obstacles that are bigger than it is.”

Yellow Necked Drywood Termite, Kalotermes flavicollis

The yellow-necked drywood termite (Kalotermes flavicollis) is a species of termite that can be found in Italy, Spain, Greece, France, Slovenia, North Africa, and the Near East. It prefers to reside in Mediterranean habitats, especially in warm coastal areas. This species is xylophagous, consuming mainly wood, so it creates nests in trees, roots, and human structures.

The yellow-necked drywood termite can reach an average length of up to .39 inches and the majority of the body is light brown or yellow in color. The neck area is yellowish orange in color, the trait from which the species received its common name, and the legs and antennae are light yellow in color. Queens and kings differ in appearance from other members of the colony, holding long wings that are used in courtship, and females are often a bit larger than males. Colonies contain three other types of termite including larvae, nymphs, and soldiers, which are white in color with brown heads.

The yellow-necked drywood termite swarms between the months of July and October, during which time courtship takes place. After breeding, the wings of both the king and queen will fall off and the pair will begin a new colony that can hold up to two thousand individuals. Young individuals do all of the work in the colonies, so there are never adult workers.

Image Caption: Kalotermes flavicollis – winged adult. Credit: Hectonichus/Wikipedia (CC BY-SA 3.0)

Air Force Satellite Tracking Program Threatened By Budget Cuts

Michael Harper for redOrbit.com – Your Universe Online

Budget cutbacks have forced the United States Air Force (USAF) to shutter its “Space Fence” satellite surveillance program. On October 1, the USAF will officially stop tracking orbiting objects or space debris that comes within a certain distance from planet Earth.

The cuts, which are a part of the sequestration, will save the Air Force as much as $14 million each year. The earliest phases of the current Space Fence were set in place in 1961 and, according to Commander of the Air Force Space Command, General William Shelton, are outdated. Though the budget cuts will take the surveillance system out of operation, General Shelton said in an official statement a new Space Fence is currently being developed that will vastly outperform the current system.

The current iteration, known as the Air Force Space Surveillance System (AFSSS) will remain in place after the October 1 deadline, though nonoperational. It will remain there until officials reach a decision about how to dispose of it properly. Though the Fence will be taken offline, the USAF will continue to search the sky for any incoming threats. According to a press release, officials will operate modified versions of the fence at Cavalier Air Force Station in North Dakota and Elgin Air Force Base in Florida. This, says an Air Force press release, will allow the military branch to shut down the fence “while still maintaining solid space situational awareness.”

The Fence is composed of three transmitters and six receivers placed strategically around the southern United States. Transmitters in Jordan Lake and Gila River, Arizona and one in Lake Kickapoo, Texas act as “fence poles” for the surveillance system, projecting a virtual fence of radar energy into space. Six receivers in Arkansas, California, Georgia, Mississippi and New Mexico are used to determine what is flying near our planet and how closely. According to the press release, two receivers in California and Georgia have already been decommissioned earlier last April.

Previously the Fence worked by broadcasting radar signals into space and receiving signals anytime an object crossed the threshold of this radio signal. Though this system quickly alerted Air Force officials about possible intruding objects, the data was sometimes spotty and not always accurate. The Air Force now says the temporary system they’ll be setting up in Florida and North Dakota will be more accurate than the old Fence.

This supplemental system will stay in place until the Air Force can complete the new system, which could be operational by 2017.

“The AFSSS is much less capable than the space fence radar planned for Kwajalein Island in the Republic of the Marshall Islands,” explained General Shelton. “In fact, it’s apples and oranges in trying to compare the two systems.”

According to an article by Forbes, the new Space Fence is so accurate it can track items as small as 4 inches wide. Though the new Fence has already been designed, the same sequestration budget cuts have prevented the USAF from awarding the final $3 billion contract to build it.

In 2009 the Air Force awarded three contracts to Lockheed Martin, Northrop Grumman and Raytheon to build the new surveillance system. The Air Force must now wait for sequestration to end before it can move forward with construction plans.

Your Eyes May Tell If You Are At Risk For Stroke

April Flowers for redOrbit.com – Your Universe Online

A new study, led by National University of Singapore, shows that your eyes may be a window to stroke risk. More specifically, the research team suggested that retinal imaging may someday help determine if you are more likely to develop a stroke, the nation’s fourth leading cause of disability.

“The retina provides information on the status of blood vessels in the brain,” said Mohammad Kamran Ikram, MD, PhD, assistant professor in the Singapore Eye Research Institute, the Department of Ophthalmology and Memory Aging & Cognition Centre, at the National University of Singapore. “Retinal imaging is a non-invasive and cheap way of examining the blood vessels of the retina.”

The results of this study were published in a recent issue of Hypertension.

The single most important risk factor for stroke globally is high blood pressure. Yet, doctors still find it impossible to predict which high blood pressure patients are most likely to develop a stroke.

The research team tracked stroke occurrence in 2,907 patients with high blood pressure for an average of 13 years. The patients had not previously experienced stroke before the study. Each participant had photographs taken of the retina at baseline. The retina is the light-sensitive layer of cells at the back of the eyeball. Damage to the blood vessels in the retina attributed to hypertension is called hypertensive retinopathy. Evidence of hypertensive retinopathy in the photographs was scored as “none,” “mild” and “moderate/severe.”

Of all the participants, 146 experienced a stroke during the follow up period caused by a blood clot. Another 15 strokes were caused by bleeding in the brain.

The scientists adjusted their findings for several stroke risk factors, including age, sex, race, cholesterol levels, blood sugar, body mass index, smoking and blood pressure readings. The team found that in patients with mild hypertensive retinopathy, the risk of stroke rose 35 percent. The risk rose 137 percent in those with moderate or severe hypertensive retinopathy.

The risk of a blood clot, even with medication and good blood pressure control, rose 96 percent in those with mild hypertensive retinopathy and 198 percent higher in those with moderate or severe hypertensive retinopathy.

“It is too early to recommend changes in clinical practice,” Ikram said. “Other studies need to confirm our findings and examine whether retinal imaging can be useful in providing additional information about stroke risk in people with high blood pressure.”

Researchers Successfully Turn A Meat-Eating Fish Into A Vegetarian

Brett Smith for redOrbit.com – Your Universe Online
University of Maryland researchers announced last week they have been able to successfully turn a fish known for eating anything, the cobia, into a vegetarian.
While altering any animal’s diet may seem unnatural or even wrong, the biologists said the development could mean big bucks for the seafood industry.
“Aquaculture isn’t sustainable because it takes more fish to feed fish than are being produced,” said Aaron Watson, a graduate assistant at the university’s Center for Environmental Science. “But a new vegetarian diet might change everything.”
According to the research team’s report in the journal Lipids, the change occurred over the course of a four-year study using various mixtures of plant-based proteins and fatty acids and an amino acid-like substance. They were eventually able to create a substance that cobia and another farmed fish, gilt-head bream, actually ate. The researchers said the formulated diet sustained the two species as well as their natural diet.
Study co-author Allen Place said the findings should come as good news to both fish farmers and conservationists alike.
“This makes aquaculture completely sustainable,” he said. “The pressure on natural fisheries in terms of food fish can be relieved. We can now sustain a good protein source without harvesting fish to feed fish.”
The new study marks the first time science has been able to convert an omnivorous fish into an herbivore – despite numerous efforts.
After securing a grant from the National Oceanic and Atmospheric Administration (NOAA), Watson began trying to demonstrate cobia could subsist on a vegetarian diet in 2009. Watson said he believed a non-meat diet would also reduce the level of contaminants, such as polychlorinated biphenyls (PCBs) and mercury, absorbed by fish feeding in polluted waters.
To make the switch, the Maryland scientists replaced conventional fish meal with a food made of corn, soy and wheat. They were also able to replace fish oil in the two species’ diet using soybean or canola oil, supplemental lipids from algae sources, and amino acid supplements, such as taurine. Popular for being used in certain energy drinks, taurine is important to the metabolism of fats, responding to stress, and muscle growth in carnivorous fish.
Watson said he modeled the diet based on observations of herbivorous trout. For a period, he experiment with feeding the cobia barley.
“Cobia were very sensitive to it,” he told the Washington Post, noting the grain often passed through the fish undigested.
While the newly formulated feed pellets “are 15 to 20 percent more expensive than the commercially available feed,” the fish that ate them grew to a bigger average size, potentially offsetting any cost issues.
In addition to being more sustainable and cost effective, researchers said the artificial diet also makes the fish healthier to eat by reducing the amount of mercury and PCBs they ingest.
“Right now, you are only supposed to eat striped bass once every two weeks,” Place said. “You can eat aquaculture-raised fish twice a week because levels are so low.”

Chronic Pain Is A Problem Few Doctors Can Address

Enid Burns for redOrbit.com – Your Universe Online

Most doctors are trained and well-equipped to treat acute pain, or pain that results from an injury and will subside with treatment, but few doctors are trained to address chronic pain. A new study from Henry Ford Hospital in Detroit finds that of the 117 US and Canadian medical schools, only four US medical schools put a required course for pain management on the schedule for medical students.

Chronic pain is a growing issue with more and more patients suffering from regular pain. The hospital estimates that 100 million people in the US live with chronic pain. It accounts for roughly a $635 billion annual split between health care costs and loss of productivity. The growing number of patients with chronic pain outnumbers medical specialists by a wide margin. The report says that a 2011 study found that for every medical specialist, there were 28,500 patients.

Many of those patients go to their general care physicians, and not specialists, to help with pain management.

“It’s a major health care problem,” said Raymond Hobbs, M.D., a Henry Ford Internal Medicine physician, and senior author of the clinical review published in the Journal of American Osteopathic Association. “We have physicians who have been well trained and have been practicing medicine a long time, but didn’t receive training in pain management.”

While acute pain results from an injury or is otherwise temporary and is resolved within three-to-six months, chronic pain persists for much longer. Chronic pain is often long-term and even lifelong. Chronic pain is also not always consistent with an injury, and for that reason can be a challenge to the doctor treating the patient.

“Pain is the most common reason a patient sees a physician. For most patients, the duration of the pain is short,” said Dr. Hobbs. “Unfortunately, for some patients the pain never goes away. It is these situations that present physicians with their greatest challenge since few are formally trained in effectively managing pain.”

The physician needs to look at the pain, but also how it affects the patient’s life, said Hobbs. Pain affects a patient in terms of psychological, social and cultural contexts.

“Negative emotions can increase the perception of chronic pain, whereas a positive emotional state can lead to a better response,” Dr. Hobbs said.

Dr. Hobbs recommends a number of strategies to help physicians work with chronic pain patients:

• Work in collaboration with a team of specialists comprising primary care, physical or occupational medicine, pain management and mental health.

• Patients being considered for oral opioid therapy like morphine, codeine and fentanyl should be screened for substance abuse using a five-point risk assessment tool.

• Set a threshold dose of 200 mg/d or less of oral morphine equivalents per day.

• Follow the so-called Universal Precaution model that calls for a complete medication evaluation and regular assessments of the four A’s of pain medicine: analgesia, activity, adverse effects and aberrant behavior.

Prescriptions of short-acting opioids help establish daily requirements for patients before long-acting opioids are prescribed.

“If large doses of breakthrough medications are needed on a regular basis, then the physician should consider increasing the long-acting medications and evaluating whether the underlying problem is worsening,” said Dr. Hobbs.

“Physicians have a moral responsibility to help their patients,” said Dr. Hobbs. “We also should realize the opportunity we have and to use it to decrease our patients’ suffering and to help restore their quality of life.”

How Can Albert Einstein Or Elvis Presley Help Spot Early Dementia?

redOrbit Staff & Wire Reports – Your Universe Online

Simple tests that measure the ability to recognize and name famous people may help doctors identify early dementia in people 40 to 65 years of age, Northwestern University researchers reported Tuesday in the journal Neurology.

“These tests also differentiate between recognizing a face and actually naming it, which can help identify the specific type of cognitive impairment a person has,” said lead author Tamar Gefen, a doctoral candidate in neuropsychology at Northwestern University Feinberg School of Medicine.

Although face recognition tests already exist to help identify dementia, they are outdated and more suitable for an older generation, the researchers said.

However, “the famous faces for this study were specifically chosen for their relevance to individuals under age 65, so that the test may be useful for diagnosing dementia in younger individuals,” said senior author Emily Rogalski, assistant research professor at Northwestern’s Cognitive Neurology and Alzheimer’s Disease Center.

An important component of the test is that it distinguishes deficits in remembering the name of a famous person from that of recognizing the same individual, Rogalski explained.

The study also used quantitative software to analyze MRI scans of the brains of participants who completed the test to understand the areas important for naming and recognition of famous faces.

The study participants were, on average, 62 years of age, and included 30 people with primary progressive aphasia, a type of early onset dementia that mainly affects language, and 27 without dementia.

The test involved 20 famous faces printed in black and white, including John F. Kennedy, Lucille Ball, Princess Diana, Martin Luther King Jr., Albert Einstein, and Elvis Presley. Participants were given points for each face they could name. If the subject could not name the face, he or she was asked to identify the famous person through description. Participants gained more points by providing at least two relevant details about the person.

The two groups then underwent MRI brain scans.

The researchers found participants with primary progressive aphasia performed significantly worse on the test, scoring an average of 79 percent in recognition of famous faces and 46 percent in naming the faces. The second group, who were without dementia, scored an average of 97 percent in recognition and 93 percent on naming.

The study also found people who experienced difficulty putting names to the faces were more likely to have a loss of brain tissue in the left temporal lobe of the brain, while those with trouble recognizing the faces had tissue loss on both the left and right temporal lobe.

“In addition to its practical value in helping us identify people with early dementia, this test also may help us understand how the brain works to remember and retrieve its knowledge of words and objects,” Gefen said.

Nine Armed Starfish, Luidia senegalensis

The nine-armed starfish (Luidia senegalensis) is a species that is classified in the Luidiidae family. It can be found in western areas of the Atlantic Ocean, with a range that includes the Caribbean Sea, The Florida coast, South American coasts, and the Gulf of Mexico. It prefers a habitat within muddy or sandy areas with plenty of seashells in protected areas like lagoons and can be found at depths of up to 130 feet.

The nine-armed starfish has a small, round body with nine long arms that extends from it, growing to a diameter between twelve to sixteen inches. A large number of plates occur on the upper side of its body and arms that hold spines and differ in color. The upper areas of the arms are grey while in outside plates are cream in color. Small, white spines occur along the edges of the arms as well as on the underbelly. The tube feet of this species are similar to those of other starfish, with suckers that help it remain steady and travel. These are slightly clear and orange in color. The mouth of this species occurs in the middle of its body disk. It can sometimes be confused with the gray sea star, which occurs in its range.

Like other species of starfish, the nine-armed starfish is both a predator and scavenger, feeding mainly on mollusks, polychaete worms, and crustaceans. These food types are consumed when the starfish turns its stomach inside out, covers its prey, and then digesting it slowly. This species is also known to dig itself into the sand, consuming small prey like brittle stars while it filters through the sediment. Individuals in the Indian River Lagoon have been found to have small polychaete worms residing on their body, living in a commensal relationship.

The breeding season of the nine-armed starfish varies depending upon the area of its range, but this species breeds the same way. Both males and females release their gametes simultaneously into the water column. Once eggs are fertilized, they develop into bipinnaria larvae that become part of the plankton in the water. After about twenty-five days, the eggs are large enough to fall to the sea floor and undergo metamorphosis into young starfish.

Image Caption: Nine-armed Starfish. Credit: Andrea Westmoreland/Wikipedia (CC BY-SA 2.0)

Raw Garlic Consumption Drastically Reduces Lung Cancer Risk

redOrbit Staff & Wire Reports – Your Universe Online
It may not do much for your breath, but new research appearing in the journal Cancer Prevention Research reveals consuming raw garlic can nearly halve a person’s risk of contracting lung cancer.
According to Hayley Dixon of The Telegraph, men and women who regularly eat the popular culinary ingredient were 44 percent less likely to suffer from the disease. Furthermore, even smokers benefitted from a garlic-eating regimen, seeing their risk of contracting lung cancer by approximately 30 percent.
The researchers from the Jiangsu Provincial Center for Disease Control and Prevention in China responsible for the study believe that the benefits might be linked to a chemical known as allicin, explained FoxNews.com. Allicin is an organosulfur compound that is released once raw garlic is diced or smashed, and it is believed to reduce inflammation and act as an antioxidant to limit damage to the body’s cells from free radicals.
The study authors analyzed information from over 1,400 lung cancer patients and 4,500 healthy adults that had been collected between the years of 2003 and 2010. Each individual was questioned about their eating habits and their overall lifestyle, including how frequently they consumed garlic and whether or not they were smokers. It is unclear at this point whether or not cooked garlic would have the same effect, Dixon said.
“A previous study at the University of South Australia concluded that garlic could decrease the risks of bowel tumors by as much as a third, while other studies have found that garlic can help to repress common colds and assist with inflammation,” FoxNews.com said. “Although numerous studies have highlighted certain health benefits from eating raw garlic, they have yet to determine whether or not cooked garlic might possess the same capabilities.”
Approximately 40,000 men and women in England and Wales are diagnosed with lung cancer each year, Dixon said, calling it “the deadliest form of the disease.” Smoking is believed to cause about 80 percent of all lung cancer cases, and under 10 percent of all people who contract the disease are still five years alive following their diagnosis.
Experts from the Nanjing Medical University School of Public Health, the Ganyu County Center for Disease Control and Prevention, the Dafeng County Center for Disease Control and Prevention, the David Geffen School of Medicine’s Center for Human Nutrition, and the UCLA Fielding School of Public Health were also involved in the research.

Researchers Aim To Study Fossil Evidence To Gain More Insight Into Evolution

redOrbit Staff & Wire Reports – Your Universe Online

The fossils of microscopic aquatic creatures, whose shells resemble grains of sand to the naked eye, could help shed new light on the process of evolution, according to new research published Friday in the journal Methods in Ecology & Evolution.

As part of their research, University of Southampton evolutionary ecologist Dr. Thomas Ezard and his colleagues are analyzing the remains of the one-millimeter large planktonic foraminifera – creatures that can be found in all of the world’s oceans and whose remains can date back several hundred million years.

Their recently-published paper “opens the debate on the best way to understand how new species come into existence,” a biological process commonly known as speciation. At the heart of the debate is whether or not fossil records, such as those belonging to the planktonic foraminifera, “contain useful evidence of speciation over and above the molecular study of evolution,” the researchers said in a statement.

Traditionally, molecular evolution utilizes evidence from species that are currently still alive in order to determine what their ancestors might have looked like. The technique used by Dr. Ezard and others, however, promotes the importance of utilizing fossil records together with molecular models.

“Because planktonic foraminifera have been around for many millions of years and rocks containing groups of their species can be dated precisely, we can use their fossils to see evidence of how species evolve over time,” Dr. Ezard said. “We can also see how differences between individual members of species develop and, in theory, how a new species comes into existence.

“The controversial hypothesis we test is that the processes leading to a new species coming into existence provoke a short, sharp burst of rapid genetic change,” he added. “This is controversial because it is very difficult to detect these new species coming into existence accurately without the fossil data; it is more commonly determined from assumptions made from the study of species alive today using molecular evidence.”

In their study, Dr. Ezard, Dr. Gavin Thomas from the University of Sheffield and Imperial College London professor Andy Purvis emphasize the importance of using both fossil and molecular evidence when studying evolution. Their goal is to make it so in the future, evolutionary research will involve the use of both types of data.

Cocaine Use Slows Fat Metabolism, Makes Recovery Even More Difficult

Brett Smith for redOrbit.com – Your Universe Online

Cocaine has long been thought to prevent weight gain in regular users by acting as an appetite suppressant, but new research from a team of UK scientists has found that the illegal drug actually has a metabolic effect that prevents the body from storing fat.

While that may be seen as a desirable side-effect, these metabolic changes can result in dramatic weight gain during recovery – making the rehabilitation process even more distressing. The study findings contradict the notion that weight gain during recovery was a result of patients replacing drug abuse with overeating.

“Notable weight gain following cocaine abstinence is not only a source of major personal suffering but also has profound implications for health and recovery,” said study co-author Karen Ersche, a behavioral scientist at the University of Cambridge. “Intervention at a sufficiently early stage could have the potential to prevent weight gain during recovery, thereby reducing personal suffering and improving the chances of recovery.”

In the study, which was published in the journal Appetite, the UK researchers recruited 60 men, half of whom were regular users of cocaine. The team evaluated participants’ body composition, eating behaviors and levels of leptin, an appetite and energy use hormone.

The British scientists found that cocaine users in the study tended to have a preference for high-fat, high-carbohydrate foods and bouts of uncontrolled eating. However these men often had significantly less body fat compared to the control group. Many of the regular users even experienced significant weight loss.

Regular users also showed lower levels of leptin that were related to the duration of cocaine use. The findings were unusual in that lower leptin levels and a high-fat diet typically lead to weight gain. The researchers said these findings indicate that users’ overeating habits pre-date any recovery process that often results in weight gain.

“We were surprised how little body fat the cocaine users had in light of their reported consumption of fatty food,” Ersche said. “It seems that regular cocaine abuse directly interferes with metabolic processes and thereby reduces body fat. This imbalance between fat intake and fat storage may also explain why these individuals gain so much weight when they stop using cocaine.”

“For most people weight gain is unpleasant but for people in recovery, who can gain several (pounds), this weight gain goes far beyond an aesthetic concern but involves both psychological and physiological problems,” she added. “The stress caused by this conspicuous body change can also contribute to relapse. It is therefore important that we better understand the effects of cocaine on eating behavior and body weight to best support drug users on their road to recovery.”

Hugh Perry, chair of the Neurosciences and Mental Health Board at the Medical Research Council that funded the study, said the study helps to inform the treatment process and could benefit individuals in the longer term.

“This research has clear implications for our understanding of how the body processes fat during chronic cocaine dependency and also how the body adjusts during withdrawal and recovery from dependency,” he said.

Understanding the Benefits Of Organic Food

Rayshell Clapper for redOrbit.com – Your Universe Online
In today’s world, we hear about organic versus conventional food all of the time and often wonder just what the benefits of organic foods are? About a year ago, redOrbit published an article explaining that organic foods have no more nutritional value than conventional foods. That is to say, the nutrients, vitamins, and minerals found in organic foods equaled those found in non-organic foods. So an orange grown organically has about the same amount of vitamin C as an orange grown conventionally has. However, there are other benefits of organic foods than just what nutrients we get from them.
First of all, what is the difference between organic and conventional foods? According to the Mayo Clinic, some of the key differences between organic and conventional foods are:
– Chemical fertilizers have been used on most conventional foods to promote plant growth, while organics use only natural fertilizers like manure or compost.
– Conventional foods are sprayed with synthetic insecticides, but organic foods use natural methods including beneficial insects and birds, mating disruption or traps.
– Conventional produce uses herbicides to manage weeds while organics use environmentally-generated plant killing compounds, crop rotation, tilling, hand weeding or mulch to control weeds.
– Conventional livestock receive antibiotics, growth hormones and medications to prevent disease and spur growth, but organics receive organic feed and access to the outdoors while using preventable measures to help minimize disease.
Both methods end up with a product to sell and eat, but organics do so using what is in nature as opposed to chemicals and medicines like conventional. As redOrbit showed, the nutritional value—as in what nutrients we gain—of each is about equal, but there are other benefits of organic food.
Helpguide.org, in collaboration with Harvard Health Publications, explains several of these benefits.
– Organic produce contains fewer pesticides. Pesticides are chemicals such as fungicides, herbicides, and insecticides. These chemicals are widely used in conventional agriculture and residues remain on (and in) the food we eat.
– Organic food is often fresher. Fresh food tastes better. Organic food is usually fresher when eaten because it doesn’t contain preservatives that make it last longer. Organic produce is often (but not always) produced on smaller farms near where it is sold.
– Organic farming is better for the environment. Organic farming practices reduce pollution (air, water and soil), conserve water, reduce soil erosion, increase soil fertility, and use less energy. In addition, organic farming is better for birds and small animals as chemical pesticides can make it harder for creatures to reproduce and can even kill them. Farming without pesticides is also safer for the workers who harvest our food.
– Organically raised animals are NOT given antibiotics, growth hormones, or fed animal byproducts. The use of antibiotics in conventional meat production helps create antibiotic-resistant strains of bacteria. This means that when someone gets sick from these strains they will be less responsive to antibiotic treatment. Not feeding animal byproducts to other animals reduces the risk of mad cow disease (BSE). In addition, the animals are given more space to move around and access to the outdoors, both of which help to keep the animals healthy. The more crowded the conditions, the more likely an animal is to get sick.
In closing, when it comes to organic food, it’s often more about what they don’t have than what they do have. Although the benefits of organic food may or may not include higher amounts of vitamins and minerals, they do provide a food product with less toxins and promote fresher foods.
Each of the benefits discussed above help make a case for eating organic. However, conventional foods have their own set of benefits, the foremost of which is simply that they are more affordable. Whether one chooses conventional foods or organic foods, it is important to know the difference and understand what it is we are eating. If we are going to be healthy eaters, we must also be informed eaters. We should know the benefits of organic foods.

NASA Reveals Plans For Asteroid-Mining Mission

[ Watch The Video: OSIRIS-REx Investigates Asteroid Bennu ]

Brett Smith for redOrbit.com – Your Universe Online

NASA announced yesterday that it will be launching a spacecraft in 2016 with the intent of laying the groundwork for future expeditions to mine asteroids.

The space agency added that the mission – dubbed the Origins, Spectral Interpretation, Resource Identification, Security and Regolith Explorer (OSIRIS- REx) – is scheduled to visit the asteroid Bennu and enable scientists to better study the origins of the universe by taking a sample of the 1,600-foot wide asteroid.

After traveling through the solar system for two years, the spacecraft is scheduled to arrive at Bennu in October 2018. It will study the asteroid for a year before returning to Earth with a sample from its surface. Because asteroids are “relics from our solar system’s formation,” the surface sample could tell scientists new details on how the planets formed and the origins of life, NASA said.

Scientists are able to determine an asteroid’s approximate composition by analyzing the light that it reflects. Using spectrometers, the OSIRIS-REx will be able to measure the intensity of light reflecting off Bennu at different frequencies and determine the asteroid’s chemical make-up.

NASA researchers said they are particularly interested in looking for organic compounds because of their importance to life as we know it. The presence of organic compounds will provide some new clues to how life emerged in the early solar system.

In addition to studying Bennu’s composition, OSIRIS- REx will also be charged with the task of determining the effect of sunlight on Bennu’s orbit. Called the Yarkovsky effect, sunlight can push an asteroid’s orbit when its surface absorbs sunlight, rotates and then radiates heat back out into space. These tiny pushes can significantly affect an asteroid’s orbit over time – potentially sending it hurtling toward Earth.

OSIRIS-REx also has a potential commercial purpose: collecting data for later use in space mining operations. Asteroids contain all kinds of useful minerals and precious metals and even the smallest asteroids could have resources worth millions of dollars. So called ‘S-type’ asteroids are of particular commercial interest because they contain significant amounts of iron, nickel and cobalt.

“A small, 10-yard S-type asteroid contains about 1,433,000 pounds of metal, with about 110 pounds in the form of rare metals like platinum and gold,” said Dante Lauretta, principal investigator for the OSIRIS-REx mission.

“The mission will be a proof-of-concept – can you go to an asteroid, get material, and bring it back to Earth,” he added. “Next, people will have to industrialize it so that the economy works out, so for the recoverable value in any given asteroid, you’re spending half that to bring it back.”

Lauretta also noted that even though the spacecraft’s mission is primarily scientific, it basically holds the same types of instruments that would be needed for a commercial mining operation.

“The only thing you might want to add is the ability to do a quick chemical analysis of material on board the spacecraft, so you can say, ‘The platinum concentration is X,’ for example,” Lauretta said. “We couldn’t afford it – that’s a pretty sporty option. Other than that, for anyone who’s thinking about an asteroid mission, this is the set of instruments that you want to fly.”

Gene Regulator Is Key To Healthy Retinal Development And Good Vision In Adulthood

Animal study reveals “unexpected” role of horizontal cells in photoreceptor rod and cone cell development of retina

Scientists are developing a clearer picture of how visual systems develop in mammals. The findings offer important clues to the origin of retinal disorders later in life.

In research published this week in the Journal of Neuroscience, University at Buffalo scientists and colleagues focused on a particular protein, called a transcription factor, that regulates gene activity necessary for the development of one type of retinal neuron, the horizontal cells.

Horizontal cells process visual information by integrating and regulating input from rod and cone photoreceptors, which allow eyes to adjust to see well in both bright and dim light conditions.

“We have found that activation of the transcription factor named Onecut1 is essential for the formation of horizontal cells,” explains Xiuqian Mu, PhD, assistant professor in the departments of Ophthalmology and Biochemistry in the UB School of Medicine and Biomedical Sciences.

The researchers came to this conclusion after creating mice that lacked Onecut1. In these knockout mice, the number of horizontal cells was 80 percent lower than in normal mice.

The researchers were surprised to find that the removal of Onecut1 also had an impact on photoreceptor cells, the rods and cones that absorb light in the retina and convert that energy to an electrical impulse eventually conveyed to the brain.

During development, Mu explains, the removal of Onecut1 only appeared to impact the horizontal cells. However, by the time these mice reached adulthood, around 8 months old, the level of photoreceptor cells in these knockout mice was less than half the normal level.

“Because degradation of photoreceptors is believed to be a major factor in retinal diseases, such as retinitis pigmentosa and Leber’s congenital amaurosis, this finding, that horizontal cells are necessary for the normal survival of photoreceptor cells, is novel and significant,” says Mu. “Many retinal diseases are manifested by the degeneration of photoreceptor cells.”

This finding was unexpected, Mu explains, because most investigations into the degeneration of photoreceptor cells have involved genes that directly affect photoreceptor cell development.

“People haven’t been looking at horizontal cells,” he says. “We didn’t think that they’d be involved in photoreceptor cell degradation.

“With this finding, we have discovered that retinal horizontal cells are required for maintaining the integrity of the retina and that their deficiency can lead to retinal degradation,” explains Mu.

He notes that in most cases where photoreceptor cells die, it’s because they are somehow defective.

“But in this case, the photoreceptor cells are fine in the beginning, so the death of the photoreceptor cells is a secondary affair that is somehow driven by the deficiency in horizontal cells,” he says.

UB co-author Steven J. Fliesler, PhD, Meyer H. Riwchun Endowed Chair Professor, vice-chair and director of research in the Department of Ophthalmology and professor in the Department of Biochemistry, notes that this finding could open up a new area of study.

“One scenario we have speculated upon is that there are important supportive interactions between horizontal cells and photoreceptors that are required to maintain photoreceptor function and viability,” Fliesler says. “When horizontal cells are blocked from being formed — the immediate consequence of knocking out Onecut1 — the photoreceptors don’t get what they need to survive, so they degenerate and die later on.”

The majority of the research was conducted in the UB Department of Ophthalmology/Ross Eye Institute and the developmental genomics group at UB’s New York State Center of Excellence in Bioinformatics and Life Sciences.

First author on the paper is Fuguo Wu of UB. Other UB co-authors are Renzhong Li, Tadeusz J. Kaczynski, Darshan Sapkota. Additional co-authors are Yumiko Umino and Eduardo Solessio of SUNY Upstate Medical University, Shengguo Li and Mengqing Xiang of the University of Medicine and Dentistry of New Jersey, David M. Sherry of the University of Oklahoma Health Sciences Center and Maureen Gannon of Vanderbilt University Medical Center.

Mu, Fliesler and Solessio also are faculty members of the SUNY Eye Institute, a SUNY-wide eye research consortium.

The work was supported by the Whitehall Foundation, the National Eye Institute, the SUNY/RF Research Collaboration Fund, Research to Prevent Blindness, the Oklahoma Center for the Advancement of Science and Technology, the Lions of Central New York, and resources and facilities provided by the Veterans Administration Western NY Healthcare System.

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Slight Global Warming May Come From Ozone Winds

April Flowers for redOrbit.com – Your Universe Online

Laypeople tend to mix up the ozone hole and global warming. The popular belief is that the hole is a major cause of the world’s increasing average temperature. On the other hand, scientists have long attributed the ozone shortage in the hole to a small cooling trend.

A new computer model study, led by the Lamont-Doherty Earth Observatory, suggests that there might be a slight warming influence from the ozone hole. The influence is due to the hole’s effect on winds, however, not temperatures. The shifting wind patterns caused by the ozone hole push clouds farther toward the South Pole, according to the findings. This reduces the amount of radiation the clouds reflect and possibly causing a bit of warming rather than cooling.

“We were surprised this effect happened just by shifting the jet stream and the clouds,” said Kevin Grise, a climate scientist at Lamont-Doherty Earth Observatory. This small warming effect may prove important in future predictions of the Southern Hemisphere climate, Grise notes.

The study findings, published in Geophysical Research Letters, are the result of a collaboration between Grise, Lorenzo Polvani of Columbia University, George Tselioudis of NASA Goddard Institute for Space Studies, Yutian Wu of New York University, and Mark Zelinka of Lawrence Livermore National Laboratory.

Three oxygen atoms bound together create an ozone molecule, and these molecules gather in the lower portion of the stratosphere – around 12 to 19 miles above ground. This is approximately twice as high as commercial airliners fly. The ozone layer shields life on the planet from some of the hazardous ultraviolet radiation barraging the atmosphere. Without that protection, UV rays can cause sunburns, eye damage and even skin cancer.

Researchers in the 1980s discovered that the ozone layer was thinning above Antarctica during the spring months in the Southern Hemisphere. The resulting “hole” was attributed to chlorofluorocarbons (CFCs), such as Freon, from cooling systems, aerosol cans and degreasing solvents, which break apart ozone molecules. The 1987 Montreal Protocol banned the use of CFCs globally, but the ozone hole persists decades later.

PERCEPTION VS. REALITY

Previous studies have found that people falsely equate the ozone hole to global warming. For example, a Yale University poll in 2010 found that 61 percent of those surveyed believed the ozone hole significantly contributed to global warming and 43 percent agreed with the statement “if we stopped punching holes in the ozone layer with rockets, it would reduce global warming.”

Perception aside, there are actual consequences to the ozone hole. One of these is its odd effect on the Southern Hemisphere polar jet stream. The polar jet stream is a group of fast flowing air currents that encircle the South Pole. The ozone hole only appears during the spring months, however, the summer after each appearance the high-speed jet stream swings south toward the pole.

“For some reason when you put an ozone hole in the Southern Hemisphere during springtime, you get this robust poleward shift in the jet stream during the following summer season,” said Grise. “People have been looking at this for 10 years and there’s still no real answer of why this happens.”

Grise and his team wondered if the hole’s impact on the jet stream has any indirect effects on the cloud cover. They used computer models to work out the clouds’ reaction to changing winds.

“Because the jet stream shifts, the storm systems move along with it toward the pole,” said Grise. “If the storm systems move, the cloud system is going to move with it.”

The researchers found that high- and mid-level clouds traveled with the shifting jet stream towards the Pole and the Antarctic continent. Low-level cloud coverage, in contrast, dropped in their models throughout the Southern Ocean. Due to the wide variety of factors that govern the formation and movement of clouds, modeling them is difficult. Grise notes, however, that their theory of migrating cloud coverage is supported by observational evidence from the International Satellite Cloud Climatology Project, a decades-long NASA effort to map global cloud distributions.

The amount of energy the clouds can reflect drops when the cloud cover moves poleward. This increases the amount of radiation that reaches the ground. “If you shift the reflector poleward,” Grise explained, “you’ve moved it somewhere there is less radiation coming in.”

The Intergovernmental Panel on Climate Change (IPCC) reported a direct cooling effect from the thinning ozone layer in 2007. This amounts to a reduction of about 0.05 watts per square meter’s worth of energy reaching the ground. The new study estimates the indirect effect of the shifting cloud cover to be an increase of approximately 0.2 watts per square meter, suggesting not only that warming rather than cooling would be taking place, but also that there’s a larger influence overall. The jet stream only shifts during the summer months, so the warming only takes place in those months.

“Theoretically this net radiation input into the system should give some sort of temperature increase, but it’s unknown if that signal could be detected or what the magnitude of it would be,” said Grise.

According to the George Washington University Solar Institute, an average of about 175 watts per square meter reaches the ground from sunlight globally.

VALIDITY CONCERNS

Since predicting cloud behavior is so challenging, the model used in Grise’s study could be underestimating clouds north of the jet stream being pulled toward the equator and in turn reflecting more light, according to Dennis Hartmann, an atmospheric scientist at the University of Washington in Seattle who was not involved in the study. This increase reflection could potentially reduce or even negate the warming effect, Hartmann added. He also noted concerns with the modeling of the low-level cloud response.

Still, “this is certainly a very interesting topic and potentially important from a practical perspective of predicting Southern Hemisphere climate and even global warming rates,” he commented.

FUTURE RESEARCH

As the ozone layer above the South Pole recovers, the jet stream should show less and less of a shift to the south during the summer months. Increasing levels of greenhouse gases, however, could also cause a change in mid-latitude wind patterns and push the jet stream poleward, creating a complicated scenario in which Grise said he plans to study in future work.

“You have sort of this tug-of-war between the jet being pulled equator-ward during the summer because of the ozone recovery and the greenhouse gases pulling the jet further poleward,” said Grise. “What the clouds do in that scenario is an open question.”

Diabetes Drug Teplizumab Proves Effective In Clinical Trials

redOrbit Staff & Wire Reports – Your Universe Online

An experimental drug developed to help prevent the advance of type 1 diabetes in its earliest stages has proven effective for approximately half of the patients involved in a two-year, phase 2 clinical trial, according to new research published online in Diabetes.

The study, which is also scheduled to appear in the November issue of the journal’s print edition, focused on 52 patients who had been diagnosed with “new-onset type 1 diabetes” within eight weeks of the start of the trial, the researchers explained. The participants, most of whom were under 14 years of age, were treated with the immunosuppressive drug teplizumab for two weeks at diagnosis, then again one year later.

The study participants then had their capacity to produce their own insulin in order to control their blood sugar levels compared with a control group that had not received teplizumab. Since participants received daily insulin injections prior to and during the trial, the researchers instead measured blood levels of C-peptide – a molecule also produced in the pancreas, typically at the same rate as insulin.

Approximately half of the study participants benefited from the experimental treatment, especially those who had relatively good control of blood sugar levels and/or only a moderate need for insulin injections prior to the start of the trial, the study authors said.

However, they noted that some patients saw their ability to produce insulin decrease by 50 percent or more – a drop similar to many of the control group members who did not receive teplizumab. The researchers said that they are not certain what caused the different results in different patients, but that it likely involves differences in the patients’ metabolic condition and the severity of their condition when the study began.

“The benefits of treatment among the patients who still had moderately healthy insulin production suggests that the sooner we can detect the pre-diabetes condition and get this kind of drug onboard, the more people we can protect from the progressive damage caused by an autoimmune attack,” Jeffrey Bluestone, PhD, co-leader of the research and a professor at the University of California, San Francisco (UCSF) who helped develop the drug, said in a statement.

According to Bluestone and his colleagues, teplizumab is one of several drugs currently being tested for their ability to control autoimmune reactions. This particular drug uses an antibody targeted against CD3, a molecule that acts as a T-cell co-receptor, to bind to those T-cells and restrain them from attacking the beta cells that store and release insulin in the body. The use of immunotherapies, currently used to treat organ transplant rejection and autoimmune diseases, is being tested as a diabetes therapy based on preclinical models and clinical trials.

The trial was led by Kevan Herold, MD, PhD an immunobiology professor at Yale University. Herold said that he and his colleagues were “very excited by the efficacy of the drug… Some of our patients and families have described a real impact on their diabetes,” and the researchers added that their findings emphasize the importance of diagnosing and treating type 1 diabetes at its earliest stages.

The research was a project of the Immune Tolerance Network, an international clinical research group aiming to accelerate the clinical development of immune tolerance therapies, and was supported by grants from the US National Institutes of Health (NIH). In addition, the authors have disclosed that Bluestone owns a patent on the teplizumab molecule, and that Herold has received grants from a pharmaceutical company which owns rights to the drug.

NASA Satellites Helps Predict Zebra Migration Patterns

[ Watch The Video: NASA Technology A Powerful Tool For Conservation ]

Brett Smith for redOrbit.com – Your Universe Online

Every year, the September rains drive African zebras on a 360-mile trek to Botswana’s Okavango Delta where the accumulating waters release a grazer’s paradise of plant life.

Using GPS collars and satellite imagery, a team of US and UK researchers is now able to more accurately predict this annual zebra migration, according to their report in the Journal of Geophysical Research – Biogeosciences.

In the past, unverified folk stories gave details of an epic zebra migration, but fencing erected in 1968 to keep a buffalo disease from spreading to livestock inadvertently prevented the zebra herds from reaching their goal.

In 2004, the fences were taken down and within three years the zebras resumed migrational movements along the Makgadikgadi Salt Pans, which leads to the Okavango Delta. Since the average zebra lifespan is around twelve years, researchers knew the behavior hadn’t been learned from previous generations.

To find out more about the migration, the study researchers tracked zebra herds using GPS collars. The GPS data was combined with satellite imagery of environmental conditions taken during the course of the migration.

To track plant growth, the researchers used the Moderate Resolution Imaging Spectroradiometer (MODIS) on board NASA’s Terra and Aqua satellites. By focusing on near-infrared light being reflected from plants, the team was able to determine growing conditions across the migration path and in the delta. The researchers also used NASA’s Tropical Rainfall Measuring Mission data to track rainfall totals, giving them rain data in three-hour intervals.

“By comparing the results of the models, it was possible to determine which environmental variables are the most effective in predicting zebra movement, and then use this knowledge to try and infer as to how the zebra make their decisions,” said study co-author Gil Bohrer, assistant professor in the Department of Civil, Environmental, and Geodetic Engineering at The Ohio State University. “It shows we can figure out very closely what ‘makes the zebra move.'”

The team said their approach could be used to inform policymakers and farmers in their land use decisions. They added that the study is particularly important in the face of climate change, which appears to be affecting migration habits.

According to study researcher Pieter Beck, research associate with the Woods Hole Research Center in Falmouth, Massachusetts, many major land migrations on Earth have already been disrupted and migratory animals are sharing limited resources with agriculture and other human activities.

“We need to know what the fate of those migrations is under climate change,” Beck said. “Understanding when animals might come through, what drives them, what they’re looking for sometimes. Being able to predict that into the future is very useful information to managing those landscapes so that migratory animals and humans can coexist.”

Bill Fagan, professor of biology at the University of Maryland, reacted positively to the study’s findings – particularly to the notion that animals can resume long-held migratory patterns.

“Their discussion was particularly intriguing as a demonstration of how important the consistency and strength of the rainfall cues were for migration success,” Fagan noted. “With so many ungulate migrations declining worldwide, it is nice to have an optimistic result about migration for a change.”

Cushion Sea Star, Choriaster granulatus

The cushion sea star (Choriaster granulatus), also known as the granulated sea star or the doughboy star, is a species of sea star that is classified within the Oreasteridae family. It is the sole species within its genus, Choriaster. It can be found in a number of tropical areas including the Red Sea, the Great Barrier Reef, the Indo-Pacific region, and along the coasts of East Africa. It prefers to reside in areas with coral reefs or detritus, as depths of up to 131 feet.

The cushion sea star is a large species, reaching an average of diameter 10.6 inches. Its arms are short and thick and do not taper to a point, like most species of starfish. Its coloring is typically pale pink with groupings of small brown papillae in the center of its disk. Like other starfish species, this species consumes detritus, carrion, and algae and one of its common predators is Triton’s trumpet, a species of sea snail.

Image Caption: A robust red sea star (Choriaster granulatus). Philippine Islands, Occidental Mindoro, Pandan Islands. Credit: Dr. Dwayne Meadows/Wikipedia (CC BY 2.0)

Dementia Risk Tied To Blood Sugar Level, Even With No Diabetes

University of Washington-Group Health study in New England Journal of Medicine

A joint Group Health–University of Washington (UW) study in the New England Journal of Medicine has found that higher blood sugar levels are associated with higher dementia risk, even among people who do not have diabetes.

Blood sugar levels averaged over a five-year period were associated with rising risks for developing dementia, in this report about more than 2,000 Group Health patients age 65 and older in the Adult Changes in Thought (ACT) study.

For example, in people without diabetes, risk for dementia was 18 percent higher for people with an average glucose level of 115 milligrams per deciliter compared to those with an average glucose level of 100 mg/dl. And in people with diabetes, whose blood sugar levels are generally higher, dementia risk was 40 percent higher for people with an average glucose level of 190 mg/dl compared to those with an average glucose level of 160 mg/dl.

“The most interesting finding was that every incrementally higher glucose level was associated with a higher risk of dementia in people who did not have diabetes,” said first author Paul K. Crane, MD, MPH, an Associate Professor of Medicine at the UW School of Medicine, Adjunct Associate Professor of Health Services at the UW School of Public Health, and Affiliate Investigator at Group Health Research Institute. “There was no threshold value for lower glucose values where risk leveled off.”

“One major strength of this research is that it is based on the ACT study, a longitudinal cohort study, where we follow people for many years as they lead their lives,” said senior author Eric B. Larson, MD, MPH, a senior investigator at Group Health Research Institute who also has appointments at the UW Schools of Medicine and Public Health. “We combine information from people’s research visits every other year with data from their visits to Group Health providers whenever they receive care. And this gave us an average of 17 blood sugar measurements per person: very rich data.”

These measurements included blood glucose (some fasting, some not) and glycated hemoglobin (also known as HbA1c). Blood sugar levels rise and fall in peaks and valleys throughout each day, but glycated hemoglobin doesn’t vary as much over short intervals. Combining glucose and glycated hemoglobin measures into a composite measure required special statistical techniques, which Drs. Crane and Larson’s co-authors Rod Walker, MS, a biostatistician, and Rebecca Hubbard, PhD, an associate investigator, both from Group Health Research Institute, had developed. (Dr. Hubbard is also an Affiliate Assistant Professor of Biostatistics at the UW School of Public Health.) These sophisticated statistical models required specialized data on the relationships between glycated hemoglobin and glucose levels, and they used data generated by co-author David M. Nathan, MD, a Professor of Medicine at Harvard Medical School and Director of the Diabetes Center at Massachusetts General Hospital.

So should people try to eat less sugar—or foods with a lower “glycemic index”? Not necessarily, Dr. Crane said: “Your body turns your food into glucose, so your blood sugar levels depend not only on what you eat but also on your individual metabolism: how your body handles your food.” But he does suggest that taking walks couldn’t hurt: The ACT study has previously linked physical activity to later onset and reduced risk of dementia, including Alzheimer’s disease.

Furthermore, Dr. Crane emphasized that these results come from an observational study: “What we found was that people with higher levels of glucose had a higher risk of dementia, on average, than did people with lower levels of glucose,” he said. “While that is interesting and important, we have no data to suggest that people who make changes to lower their glucose improve their dementia risk. Those data would have to come from future studies with different study designs.”

More research is planned to delve into various possible mechanisms for the relationship between blood sugar and dementia. “This work is increasingly relevant,” Dr. Crane said, “because of the worldwide epidemics of dementia, obesity, and diabetes.”

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Absorbent Nanofibers Show Promise In Brain Infection Treatment

April Flowers for redOrbit.com – Your Universe Online

A team of scientists, led by Chang Gung University, report a plastic material already used in absorbent surgical sutures and other medical devices shows promise for continuous administration of antibiotics to patients with brain infections. The findings, reported in ACS Chemical Neuroscience, show the use of the material, placed directly on the brain’s surface, could reduce the need for weeks of costly hospital stays now required for such treatment.

Professor of Mechanical Engineering at Chang Gung University (CGU), Taiwan, Shih-Jung Liu and his colleagues explain in approximately 5-10 percent of patients undergoing brain surgery, infections become life-threatening complications. Currently, treatment for such infections involves intravenous antibiotics for up to eight weeks and extended, costly hospital stays.

Prior research has shown drug delivering plastics could release antibiotics directly into the brain, but additional surgeries were needed to remove the plastic when the treatment course was completed. Liu and his team wanted to create a biodegradable option using a dissolvable plastic called PLGA.

The team describes the development of PLGA fibers that release vancomycin. Vancomycin is a powerful antibiotic that kills many microbes, including the infamous “MRSA,” which shrugs off most other known antibiotics. The team tested their fibers in rat models, which stand in for humans in these types of studies. The PLGA fibers successfully released the antibiotic for more than eight weeks in the brain, without any apparent side effects.

Mobile Tweets Used To Predict Likelihood Of Foodborne Illness

redOrbit Staff & Wire Reports – Your Universe Online

Researchers at the University of Rochester have devised a new system that can tell people how likely they are to become ill when dining at a particular restaurant by “listening” to the tweets from other restaurant patrons.

The system, dubbed nEmesis, can help people make more informed decisions and could potentially complement traditional public health methods for monitoring food safety, the researchers said.

The system works by combining machine-learning and crowdsourcing techniques to analyze millions of tweets to identify people reporting food poisoning symptoms after visiting a restaurant.

Such a large volume of tweets would be impossible to analyze manually, the researchers noted. Indeed, over a four-month period, nEmesis gathered 3.8 million tweets from more than 94,000 unique users in New York City, traced 23,000 restaurant visitors, and found 480 reports of likely food poisoning – data that correlated fairly well with public inspection figures given by the local health department.

The nEmesis system then ranked restaurants according to how likely it is for someone to become ill after dining there.

“The Twitter reports are not an exact indicator – any individual case could well be due to factors unrelated to the restaurant meal – but in aggregate the numbers are revealing,” said Henry Kautz, chair of the computer science department at the University of Rochester and co-author of a paper about the system to be presented at the Conference on Human Computation & Crowdsourcing in November.

In other words, a “seemingly random collection of online rants becomes an actionable alert” that can help detect cases of foodborne illness in a timely manner, Kautz said.

Since people often tweet from their phones or other mobile devices, which are GPS enabled, nEmesis can “listen” to relevant, geo-tagged public tweets and detect restaurant visits by matching up the location from where the tweet was sent and the known locations of restaurants.

If a user tweets from a location that is determined to be a restaurant, the system will continue to track that person’s tweets for 72 hours, even if they are not geotagged or if the person is tweeting from a different device.

If a user later tweets about feeling ill, the system captures that data.

The correlation between the Twitter data and the public inspection data means about one third of the inspection scores could be reliably predicted from the Twitter data, with the remainder showing some divergence.

“This disagreement is interesting as the public inspection data is not perfect either,” wrote study co-author Adam Sadilek, formerly a colleague of Kautz at Rochester and who is now at Google.

“The adaptive inspections could reveal the real risk, which is currently hidden for both methods.”

The current work builds on an earlier collaboration by Kautz and Sadilek that used Twitter to determine how likely a specific user was to have flu-like symptoms, and also to find the influence of different lifestyle factors on health.

At the heart of all this work is the algorithm based on machine-learning that Sadilek developed to distinguish between tweets that suggest the user is unwell and those that don’t.

“It’s like teaching a baby a new language,” only in this case it’s a computational algorithm that is being taught, Sadilek said.

For nEmesis, Kautz and Sadilek introduced an extra layer of complexity to improve the algorithm – crowdsourcing.

The researchers turned to Amazon’s Mechanical Turk system to reach out to a crowd of readily available workers, each of whom were paid small amounts of money to categorize some tweets that could be used to train the algorithm.

To ensure the pool of tweets was of high enough accuracy, more than one worker examined each tweet. The researchers incentivized the right answer by paying workers when their answers agreed with that of the majority, and deducting money when it didn’t.

Using this collection of tweets allowed the algorithm to learn from the training samples how to identify tweets that showed people who were likely to have foodborne illnesses.

The researchers acknowledge the system only considers people who tweet, which may not be a representative sample of those visiting a particular restaurant. However, Twitter data can be used together with information from other sources to detect foodborne illness in a timely manner. It can also provide an extra layer – a passive level of monitoring – that is cost-effective and can benefit everyone.

From Harmless Colonizers To Virulent Pathogens: UB Microbiologists Identify What Triggers Disease

The bacteria Streptococcus pneumoniae harmlessly colonizes the mucous linings of throats and noses in most people, only becoming virulent when they leave those comfortable surroundings and enter the middle ears, lungs or bloodstream. Now, in research published in July in mBio, University at Buffalo researchers reveal how that happens.

“We were asking, what is the mechanism behind what makes us sick?†explains Anders P. Hakansson, PhD, assistant professor of microbiology and immunology in the UB School of Medicine and Biomedical Sciences. “We are looking to find ways to interfere with the transition to disease. Few have looked at the specific mechanism that suddenly makes these bacteria leave the nose where they typically prefer to reside and travel into the lungs or the middle ear where they cause disease. If we can understand that process, then maybe we can block it.â€

Hakansson and his colleagues had previously found that when the pneumococci colonize the nose, they form sophisticated, highly structured biofilm communities.

In the current study, the research team grew biofilms of pneumococci on top of human epithelial cells, where the bacteria normally grow. They then infected these bacteria with influenza A virus or exposed them to the conditions that typically accompany the flu, including increased temperature to mimic fever, increased concentrations of ATP (the energy molecule in cells), and the stress hormone norepinephrine, released during flu infection.

All three stimuli triggered a sudden release and departure of bacteria from the biofilm in the nose into otherwise normally sterile organs, such as the middle ears and lungs or into the bloodstream. At the same time, the researchers found that the gene expression profile of the bacteria that had dispersed from the biofilms revealed far more virulence.

Hakansson says the research demonstrates how the mammalian and bacterial kingdoms interact. “Humans are the only natural hosts for these bacteria,†he explains, “when the viral infection comes in, there is this interkingdom signaling, where the bacteria respond to host molecules. If we can find ways to interrupt that signaling, we might be able to prevent disease.â€

Hakansson is affiliated with the Witebsky Center for Microbial Pathogenesis and Immunology and the New York State Center of Excellence in Bioinformatics and Life Sciences, both at UB. The major portion of the work was conducted by co-author Laura R. Marks, an MD/PhD candidate in the UB Department of Microbiology and Immunology, with co-authors Bruce A. Davidson, research assistant professor of anesthesiology and Paul R. Knight, III, MD, PhD, professor of anesthesiology and microbiology and immunology.

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Volunteer Mars Colonists Gather In D.C.

Michael Harper for redOrbit.com – Your Universe Online

Forty of the volunteers chosen to take a one-way trip to the Red Planet gathered in Washington, DC yesterday to hear Dutch entrepreneur Bas Lansdorp explain his plans to build a permanent base on Mars by 2023. Should Lansdorp succeed in raising the necessary $6 billion to send these volunteers to Earth’s neighbor, they’ll embark on a seven-month, one-way journey to set up the planet’s first colony.

Lansdorp’s non-profit organization, called Mars One, first plans to establish a communications satellite on Mars in 2016 before sending out the volunteers in groups of four. Every two years new groups will be sent to live and ultimately die on Martian soil. Two of the volunteers who have applied to go to Mars say they’re excited to discover new lands and open up exploration for future generations.

“How could you not be excited?” said Michael Tamits, an 18-year old volunteer from Australia, speaking to the Sydney Morning Herald. “This is without doubt the most ambitious life endeavor known to man.”

Christine Rambo, a 38-year-old student librarian from New Jersey told the AFP she feels like Columbus discovering America for the first time.

“It is so exciting and such a great achievement, I want to be a part of it.”

Mars One was introduced last June by Lansdorp, a researcher from the Netherlands with a Masters in Science from Delft University of Technology. Once the first human colony is built on Mars in 2023, the volunteer astronauts will begin building an environment for themselves and incoming colonials as well as looking for signs of life on the Red Planet.

Mars One began taking applications this year for volunteer astronauts, and the criteria to be selected for the mission are generally easy to meet. Applicants only need to be 18 years of age and have what Space One calls a “deep sense of purpose,” and a “willingness to build and maintain healthy relationships.”

The group even makes a point to say they aren’t looking for people with specific skill sets, noting that they’ll train the right volunteers for eight years before they venture off into space. Though they’re currently taking applications for volunteer astronauts, the final selections will not be made until next year. To raise awareness for the mission, the volunteers will be selected during a reality TV broadcast.

Lansdorp told the AFP that Mars One hasn’t yet raised all of the $6 billion it will take to embark on this mission. Applicants must pay $30 to be considered and the organization is selling merchandise (hoodies, shirts, mugs, etc) to help them towards their goal. Though he didn’t say how much money they’ve raised, he did say more than 78,000 people have volunteered to die on Mars.

The prospect sounds grim enough, but Tamits says he doesn’t mind the idea of spending the rest of his young days living his life on Martian soil.

“I’d rather die looking upon Earth from outer space than to be on my deathbed thinking I could have had my chance.”

Gum Tissue Stem Cells Heal Fast And Fight Inflammation

April Flowers for redOrbit.com – Your Universe Online

A new study from the Ostrow School of Dentistry of the University of Southern California (USC) reveals stem cells found in mouth tissue can relieve inflammatory disease, as well as become other types of cells.

The study, published in a recent issue of the Journal of Dental Research, focused on gingival mesenchymal stem cells (GMSC) that are found in the gingival, or gum tissue, of the mouth. Like other stem cells, GMSC have the ability to develop into different types of cells as well as affect the immune system.

“Gingiva is very unique in our body,” says Professor Songtao Shi, associate professor at the Center for Craniofacial Molecular Biology. “It has much less inflammatory reaction and heals much faster when compared to skin.”

Before this study, the developmental origins and abilities of GMSC had not been fully demonstrated. The USC researchers reveal there are two types of GMSC. The first type, M-GMSC, arrives from the mesoderm layer of cells during embryonic development. The second type, N-GMSC, originate from cranial neural crest cells that develop into many important structures of the head and face. N-GMSC were found to comprise 90 percent of the gingival stem cells.

M-GMSC and N-GMSC vary dramatically in their abilities, the team found. In addition to being easier to change into other types of cells, including neural and cartilage-producing cells, N-GMSC also have more of a healing effect on inflammatory disease than M-GMSC. When mice with dextrate sulfate sodium-induced colitis – an inflamed condition of the colon – received transplants of N-GMSC, the inflammation was dramatically reduced.

The study findings suggest the stem cells in the gingiva – obtained via a simple biopsy of the gums – may have important medical applications in the future.

“We will further work on dissecting the details of the gingiva stem cells, especially their notable immunoregulatory property,” says Xingtian Xu, specialized lab technician at the Ostrow School of Dentistry Center for Craniofacial Molecular Biology.

“Through the study of this unique oral tissue, we want to shed the light on the translational applications for improving skin wound healing and reducing scar formation.”

Researchers Reveal Genes That Drive Brain Cancer

Columbia University Medical Center

Columbia researchers find that about 15 percent of glioblastoma patients could receive personalized treatment with drugs currently used in other cancers

A team of researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center has identified 18 new genes responsible for driving glioblastoma multiforme, the most common — and most aggressive — form of brain cancer in adults. The study was published August 5, 2013, in Nature Genetics.

“Cancers rely on driver genes to remain cancers, and driver genes are the best targets for therapy,” said Antonio Iavarone, MD, professor of pathology and neurology at Columbia University Medical Center and a principal author of the study.

“Once you know the driver in a particular tumor and you hit it, the cancer collapses. We think our study has identified the vast majority of drivers in glioblastoma, and therefore a list of the most important targets for glioblastoma drug development and the basis for personalized treatment of brain cancer.”

Personalized treatment could be a reality soon for about 15 percent of glioblastoma patients, said Anna Lasorella, MD, associate professor of pediatrics and of pathology & cell biology at CUMC.

“This study — together with our study from last year, Research May Lead to New Treatment for Type of Brain Cancer — shows that about 15 percent of glioblastomas are driven by genes that could be targeted with currently available FDA-approved drugs,” she said. “There is no reason why these patients couldn’t receive these drugs now in clinical trials.”

New Bioinformatics Technique Distinguishes Driver Genes from Other Mutations

In any single tumor, hundreds of genes may be mutated, but distinguishing the mutations that drive cancer from mutations that have no effect has been a longstanding problem for researchers.

The Columbia team used a combination of high throughput DNA sequencing and a new method of statistical analysis to generate a short list of driver candidates. The massive study of nearly 140 brain tumors sequenced the DNA and RNA of every gene in the tumors to identify all the mutations in each tumor. A statistical algorithm designed by co-author Raul Rabadan, PhD, assistant professor of biomedical informatics and systems biology, was then used to identify the mutations most likely to be driver mutations. The algorithm differs from other techniques to distinguish drivers from other mutations in that it considers not only how often the gene is mutated in different tumors, but also the manner in which it is mutated.

“If one copy of the gene in a tumor is mutated at a single point and the second copy is mutated in a different way, there’s a higher probability that the gene is a driver,” Dr. Iavarone said.

The analysis identified 15 driver genes that had been previously identified in other studies — confirming the accuracy of the technique — and 18 new driver genes that had never been implicated in glioblastoma.

Significantly, some of the most important candidates among the 18 new genes, such as LZTR1 and delta catenin, were confirmed to be driver genes in laboratory studies involving cancer stem cells taken from human tumors and examined in culture, as well as after they had been implanted into mice.

A New Model for Personalized Cancer Treatment

Because patients’ tumors are powered by different driver genes, the researchers say that a complicated analysis will be needed for personalized glioblastoma treatment to become a reality. First, all the genes in a patient’s tumor must be sequenced and analyzed to identify its driver gene.

“In some tumors it’s obvious what the driver is; but in others, it’s harder to figure out,” said Dr.Iavarone.

Once the candidate driver is identified, it must be confirmed in laboratory tests with cancer stem cells isolated from the patient’s tumor.

“Cancer stem cells are the tumor’s most aggressive cells and the critical cellular targets for cancer therapies,” said Dr. Lasorella. “Drugs that prove successful in hitting driver genes in cancer stem cells and slowing cancer growth in cell culture and animal models would then be tried in the patient.”

Personalized Treatment Already Possible for Some Patients

For 85 percent of the known glioblastoma drivers, no drugs that target them have yet been approved.

But the Columbia team has found that about 15 percent of patients whose tumors are driven by certain gene fusions, FDA-approved drugs that target those drivers are available.

The study found that half of these patients have tumors driven by a fusion between the gene EGFR and one of several other genes. The fusion makes EGFR — a growth factor already implicated in cancer — hyperactive; hyperactive EGFR drives tumor growth in these glioblastomas.

“When this gene fusion is present, tumors become addicted to it — they can’t live without it,” Dr. Iavarone said. “We think patients with this fusion might benefit from EGFR inhibitors that are already on the market. In our study, when we gave the inhibitors to mice with these human glioblastomas, tumor growth was strongly inhibited.”

Other patients have tumors that harbor a fusion of the genes FGFR (fibroblast growth factor receptor) and TACC (transforming acidic coiled-coil), first reported by the Columbia team last year. These patients may benefit from FGFR kinase inhibitors. Preliminary trials of these drugs (for treatment of other forms of cancer) have shown that they have a good safety profile, which should accelerate testing in patients with glioblastoma.

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Study Says Ozone-protection Treaty Had Climate Benefits Also

The Earth Institute at Columbia University
The global treaty that headed off destruction of earth’s protective ozone layer has also prevented major disruption of global rainfall patterns, even though that was not a motivation for the treaty, according to a new study in the Journal of Climate.
The 1987 Montreal Protocol phased out the use of chloroflourocarbons, or CFCs, a class of chemicals that destroy ozone in the stratosphere, allowing more ultraviolet radiation to reach earth’s surface. Though the treaty aimed to reverse ozone losses, the new research shows that it also protected the hydroclimate. The study says the treaty prevented ozone loss from disrupting atmospheric circulation, and kept CFCs, which are greenhouse gases, from warming the atmosphere and also disrupting atmospheric circulation. Had these effects taken hold, they would have combined to shift rainfall patterns in ways beyond those that may already be happening due to rising carbon dioxide in the air.
At the time the Montreal Protocol was drafted, the warming potential of CFCs was poorly understood, and the impact of ozone depletion on surface climate and the hydrological cycle was not recognized at all. “We dodged a bullet we did not know had been fired,” said study coauthor Richard Seager, a climate scientist at Columbia University’s Lamont-Doherty Earth Observatory.
Today, rising carbon dioxide levels are already disturbing earth’s hydrological cycle, making dry areas drier and wet areas wetter. But in computer models simulating a world of continued CFC use, the researchers found that the hydrological changes in the decade ahead, 2020-2029, would have been twice as severe as they are now expected to be. Subtropical deserts, for example in North America and the Mediterranean region, would have grown even drier and wider, the study says, and wet regions in the tropics, and mid-to-high latitudes would have grown even wetter.
The ozone layer protects life on earth by absorbing harmful ultraviolet radiation. As the layer thins, the upper atmosphere grows colder, causing winds in the stratosphere and in the troposphere below to shift, displacing jet streams and storm tracks. The researchers’ model shows that if ozone destruction had continued unabated, and increasing CFCs further heated the planet, the jet stream in the mid-latitudes would have shifted toward the poles, expanding the subtropical dry zones and shifting the mid-latitude rain belts poleward. The warming due to added CFCs in the air would have also intensified cycles of evaporation and precipitation, causing the wet climates of the deep tropics and mid to high latitudes to get wetter, and the subtropical dry climates to get drier.
The study builds on earlier work by coauthor Lorenzo Polvani, a climate scientist with joint appointments at Lamont-Doherty and Columbia’s Fu Foundation School of Engineering and Applied Science. Polvani and others have found that two human influences on climate — ozone loss and industrial greenhouse gases — have together pushed the jet stream in the southern hemisphere south over recent decades. As the ozone hole over Antarctica closes in the coming decades, the jet stream will stop its poleward migration, Polvani found in a 2011 study in the journal Geophysical Research Letters. The projected stopping of the poleward jet migration is a result of the ozone hole closing, canceling the effect of increasing greenhouse gases.
“We wanted to take a look at the more drastic scenario — what would have happened if there had been no Montreal Protocol?” said study lead author Yutian Wu, a former Lamont graduate student who is now a postdoctoral researcher at New York University. “The climatic impacts of CFCs and ozone depletion were not known back then.”
The Montreal Protocol is considered one of the most successful environmental treaties of all time. Once scientists linked CFCs to rapid ozone loss over Antarctica, world leaders responded quickly. Nearly 200 countries have ratified the treaty. The ozone depletion that CFCs would have caused is now known to have been far worse than was realized at the time, in 1987. The cost of developing CFC-substitutes also turned out to be far less than the industry estimated.
“It’s remarkable that the Montreal Protocol has not only been important in protecting the ozone layer and in decreasing global warming but that it also has had an important effect on rainfall patterns and reducing the changes we are in for,” said Susan Solomon, an atmospheric scientist at the Massachusetts Institute of Technology who won the Vetlesen Prize earlier this year for her work on ozone depletion. Solomon was not involved in the study.
As a greenhouse gas, CFCs can be thousands of times more potent than carbon dioxide. Dutch scientist Guus Velders estimated in a 2007 study that had the chemicals not been phased out, by 2010 they would have generated the warming equivalent of 220 billion tons of carbon dioxide, (Humans produced 32 billion tons of CO2 in 2011).
Hydroflourocarbons, or HFCs, have largely replaced CFCs as refrigerants, aerosol propellants and other products. While HFCs are ozone-safe, they, too, are powerful greenhouse gases that have become a concern as world leaders grapple with climate change. The Kyoto Protocol was drafted to regulate global greenhouse gas emissions, but its expiration at the end of 2012 has led some countries to seek climate protections from the Montreal Protocol. Canada, Mexico and the United States have asked that HFCs be regulated under Montreal, though the treaty was never intended to limit greenhouse gases. So far no action has been taken.
“This research supports the principle that it’s generally best not to put things into the environment that weren’t there before,” said Scott Barrett, an economist at the Earth Institute who was not involved in the study. “It’s a lesson, surely, for our current efforts to limit greenhouse gas emissions.”

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Greenhouse World: Are Our Oceans Headed For The Same Fate?

April Flowers for redOrbit.com – Your Universe Online

A new study, led by Scripps Institution of Oceanography, reveals the look of the oceans will change drastically in the future as the coming greenhouse world alters marine food webs and gives certain species advantages over others, if history’s closest analog is any indication.

Richard Norris, paleobiologist at Scripps Institution of Oceanography, UC San Diego, worked with an international team of scientists to show the ancient greenhouse world had few large reefs, a poorly oxygenated ocean, tropical surface waters like a hot tub, and food webs that did not sustain the abundance of large sharks, whales, seabirds, and seals of the modern ocean. If greenhouse gases continue to rise at the current accelerating rates, aspects of this greenhouse ocean could reappear.

The study, published in Science, is based on what is known about the “greenhouse world” of 50 million years ago. During this time, the levels of greenhouse gases were much higher than those that have been present at any point during human history.

Atmospheric CO2 concentrations have never exceeded 280 parts per million (ppm) during the past million years. Industrialization, forest clearing, agriculture, and other human activities, however, have caused rapid increases in CO2 and other gases known to create a “greenhouse” effect that traps heat in the atmosphere. For the first time in human history, CO2 levels exceeded 400 ppm in May 2013, although those numbers have since been revised. In the coming decades, that milestone could be left well behind. The researchers say at its current pace, Earth could recreate the CO2 content of the atmosphere in the greenhouse world in just 80 years.

Fossils from the greenhouse world period indicate CO2 concentrations reached 800-1,000 parts per million during that time. Other extreme measurements include tropical ocean temperatures reaching 95 degrees F, and polar oceans that were around 50 degrees F, similar to the ocean temperatures off the coast of San Francisco currently. The greenhouse world had no polar ice sheets. Between 42 and 57 million years ago, scientists have identified a “reef gap” in which complex coral reefs largely disappeared and the seabed was dominated by piles of pebble-like single-celled organisms called foraminifera.

“The ‘rainforests-of-the-sea’ reefs were replaced by the ‘gravel parking lots’ of the greenhouse world,” said Norris.

Differences in the ocean food web with large parts of the tropical and subtropical ocean ecosystems supported by minute picoplankton instead of the larger diatoms typically found in highly productive ecosystems today marked the greenhouse world as well. In the cold oceans of recent geologic times, large marine animals such as sharks, tuna, whales, seals and even seabirds became abundant when algae became large enough to support top predators.

“The tiny algae of the greenhouse world were just too small to support big animals,” said Norris. “It’s like trying to keep lions happy on mice instead of antelope; lions can’t get by on only tiny snacks.”

Rapid warming events within the greenhouse world resemble our projected future. One such event, the well-studied Paleocene-Eocene Thermal Maximum (PETM), happened 56 million years ago and serves as a guide to predicting what may happen under current climate trends.

The PETM lasted approximately 200,000 years and warmed the planet by 9-16 degrees F, causing massive migrations of animals and plants and shifts in climate zones. The extinction of species was remarkably light, other than a mass extinction in the rapidly warming deep ocean, despite the disruption to the planet’s ecosystems.

“In many respects the PETM warmed the world more than we project for future climate change, so it should come as some comfort that extinctions were mostly limited to the deep sea,” said Norris. “Unfortunately, the PETM also shows that ecological disruption can last tens of thousands of years.”

Continuing the current fossil fuel economy even for decades magnifies the period of climate instability, Norris added. Abruptly halting fossil fuel use at current levels could limit future climate instability to less than 1,000 years before Earth’s climate would largely return to pre-industrial norms. If, however, our fossil fuel consumption remains on its current trajectory until the end of this century, projections show the climate effects beginning to resemble those of the PETM. Major ecological changes could last 20,000 years or more, with a recognizable human “fingerprint” on Earth’s climate lasting for 100,000 years.

Want To Lose Weight? Try Eating A Big Breakfast

Brett Smith for redOrbit.com – Your Universe Online

Many health experts recommend a balanced breakfast to start each day and new research from Tel Aviv University in Israel has shown that a ‘big breakfast’ diet can even lead to more efficient weight loss when compared to a big dinner diet.

According to their report in the journal Obesity, the Israel-based team found that when overweight and obese women were given a weight-loss diet with the same amount of daily caloric intake, those who ate more for breakfast than dinner tended to lose more weight than those who did the opposite and feasted at night.

To investigate the health effects of meal timing, the research team enlisted 93 obese women who were randomly placed into one of two groups. Both groups were told to consume a moderate-carbohydrate, moderate-fat, 1,400-calorie-a-day diet for 12 weeks. The first group was told to eat 700 calories at breakfast, 500 at lunch, and 200 at supper. The other group had a 200 calorie breakfast, 500 calorie lunch, and 700 calorie dinner. Both groups’ 700-calorie meals included the same foods.

At the end of the twelve weeks, the “big breakfast” volunteers had lost an almost of 18 pounds each, on average. They also lost three inches off their waist line. The “big dinner†group averaged a 7.3-pound weight loss and 1.4 inches of lost waistline.

The breakfast group was also found to have noticeably lower levels of insulin, glucose, and triglycerides throughout the day, which could eventually lead to a lower risk of cardiovascular disease, diabetes, hypertension, and high cholesterol, added the researchers.

They also noted that the big breakfast group also had lower levels of the hunger-regulating hormone ghrelin, suggesting that these women were more satiated throughout the day than their counterparts in the other group. The breakfast group also did not experience blood glucose spikes that often occur after a meal. Some experts consider these jumps in blood sugar levels more harmful than sustained high blood glucose levels with respect to cardiovascular disease.

According to the researchers, the results indicate that proper meal timing should be considered when attempting to manage obesity, in addition to a regular exercise regimen and proper nutrition. The study authors also suggested that people minimize late-night snacking or mindless eating in front of the television screen.

One of the study’s authors – Daniela Jakubowicz, a diabetes expert at Wolfson Medical Center in Holon, Israel – has been espousing the virtues of a large breakfast for years and even has a diet book based on the principle.

In a review of Jakubowicz’s 2009 book The Big Breakfast Diet: Eat Big Before 9 a.m. and Lose Big for Life,” Los Angeles Times’ critic Anne Colby noted that most women would lose weight on the diabetes researcher’s recommended 1,100 calories-a-day diet. Colby added that a major drawback of the plan is that it slightly runs counter to social norms.

“The main drawback to the big-breakfast diet would seem to be the fact that people eat not just to satisfy hunger or cravings, but as a social activity,” Colby wrote in 2010. “And dinner is when they typically gather to break bread. Sure you can order up a vegetable platter or salad while others are noshing on pesto pasta and pizza, but it takes commitment.”

Brain’s Long-Term Reward System Relies On Dopamine

Brett Smith for redOrbit.com – Your Universe Online

From driving across country to graduating from college, long-term goals are often difficult to stay focused on when an immediate reward isn’t within sight.

A team of researchers from the University of Washington in Seattle and MIT has recently discovered new details on how the brain is able to stay focused until these long-term goals are achieved, according to a report in the journal Nature.

The joint teams research builds on previous studies that have linked the neurotransmitter dopamine to the brain’s reward system. While most previous studies have involved looking at dopamine with respect to an immediate reward, the new study found increasing levels of dopamine as laboratory rats approached an expected reward after delayed gratification.

To measure levels of dopamine in the rats’ brains, the team used a system developed by UW behavioral scientist Paul Phillips called fast-scan cyclic voltammetry (FSCV) that involves small, implanted electrodes that continuously record dopamine concentration by looking for its electrochemical signature.

“We adapted the FSCV method so that we could measure dopamine at up to four different sites in the brain simultaneously, as animals moved freely through the maze,” said co-author Mark Howe, currently a post-doctoral neurobiologist at Northwestern University. “Each probe measures the concentration of extracellular dopamine within a tiny volume of brain tissue, and probably reflects the activity of thousands of nerve terminals.”

The scientists started by training rats to find their way through a maze in search of a reward. During each rat’s run through the maze, a tone would sound instructing it to turn right or left at an intersection in pursuit of a chocolate milk reward.

The research team said they expected to see pulses of dopamine being released by the rats’ brain at periodic intervals during the trials. However, they found that levels of the neurotransmitter steadily rose throughout the experiment — culminating in a peak level as the rodent neared its reward. While the rats’ behavior during each trial varied, their dopamine levels reliably rose despite running speed or probability of reward.

“Instead, the dopamine signal seems to reflect how far away the rat is from its goal,” said Ann Graybiel, who runs a brain research laboratory at MIT. “The closer it gets, the stronger the signal becomes.”

The team also discovered that the magnitude of the dopamine signal was associated with the size of the expected reward. When rats were conditioned to expect a larger serving of chocolate milk, their dopamine levels rose more rapidly to a higher peak.

Researchers varied the experiment by extending the maze to a more complex shape that made the rats run farther and make additional turns to reach the prize. During these longer trials, the dopamine signal increased more gradually, but eventually reached the same level as in the previous maze.

“It’s as if the animal were adjusting its expectations, knowing that it had further to go,” Graybiel said.

She suggested that future studies should look into this same phenomenon in humans.

“I’d be shocked if something similar were not happening in our own brains,†Graybiel said.

A List Of GMO Foods: The Basics

Rayshell Clapper for redOrbit.com – Your Universe Online

Many people would like to have a list of GMO foods to help them when deciding what foods to purchase while they’re wandering through the produce aisle of their local grocery store. GMO stands for ‘genetically modified organism’ and usually refers to plant or animal products that have had their DNA altered in order to make the food higher in nutrient content, resistant to disease, or to confer some other benefit (or alleged benefit) for either the farmer or the consumer.

For some people,
any form of genetic modification is suspect, and those interested in all-natural and organic foods tend to avoid GMO foods. However, others see GMO products as beneficial. For some foods, it helps them to grow stronger or adds nutrients, while others that are genetically modified are done so to protect the organism against insects, parasites or other disease.

Whatever your stand on genetically modified organisms may be, the following GMO foods list is meant to help identify some of the main GMO foods in order to help you make more informed choices regarding what to purchase and eat. While this is by no means a complete list, it includes some of the most common GMO foods.

1. Corn

Corn is perhaps the most controversial on the list of GMO foods because corn is so ubiquitous in the American diet. From corn syrup to corn starch to corn oil and just plain old corn and corn meal, Americans ingest an enormous amount of corn every year. For just that reason, there is growing concern this produce is a GMO food. According to Natural Society, “Monsanto’s GMO corn has been tied to numerous health issues, including weight gain and organ disruption.”

Monsanto is one of the largest and most notorious producers of many of the GMO foods that fill the produce sections of America’s supermarkets. As Discovery.com notes, though, “Bt-corn (named after the Bacillus thruringiensis bacterium) is a form of sweet corn that has been genetically modified to include an insect-killing gene. This means the farmer doesn’t have to spray with pesticides, because the insects die from eating the corn. No spraying means less harm to the environment and the workers handling the toxic spray. The move has caused debate, however. The same gene that attacks corn predators also appears to kill the Monarch butterfly.”

Another aspect of the corn controversy is that the US is the largest producer of corn worldwide, so any danger to corn affects more than just those within our border.

2. Tomatoes

Tomatoes were the first GMO food to reach the market. They are a part of the GMO food list because they are modified specifically to avoid rotting so quickly. Moreover, as Discovery.com explains, “The original GM tomatoes were resistant to antibiotics. This raised concerns the gene might be passed on to humans, making us more resistant to antibiotics and in turn less capable of fighting infectious diseases.”

3. Soy

Another important product on the list is the humble soybean. Soy can be found in tofu, countless vegetarian products, soybean oil, soy flour, and numerous other products. Most strains of soy that make it to grocery stores have been genetically modified to resist herbicides. And as Discovery.com points out, “Because soy is widely used in the production of other items (including cereal, baked products, chocolate and even ice cream), chances are everybody in the US is eating GM soy.”

These are three big items on any list of GMO foods, but several others exist as well. In
no particular order some of these include:
Dairy
Cotton
Oils (like Canola)
Papayas
Sugar
Animal Feed
Salmon
Golden Rice
Squash
Sugar Beets
Potatoes
Each one of these is commonly genetically modified for its own specific reasons. If you do not want to eat GMO foods, then the best course is to make sure the foods you purchase have a specific non-GMO label. This is a bit difficult in the US because these labels are not mandatory by the Food and Drug Administration (FDA) – at least not yet.

Eating Grapes Can Lead To A Healthier You

Susan Bowen for redOrbit.com – Your Universe Online
If you eat grapes regularly, chances are you are healthier than people who don’t. A new observational study, published in the Journal of Food Science, showed an association between grape consumption – including fresh grapes, raisins and 100 percent grape juice – and healthier dietary patterns and nutrient intakes.
By analyzing the diets of more than 221,800 children and adults using data from the 2003-2008 National Health and Nutrition Examination Survey, researchers found people who consumed grapes and grape products had increased levels of vitamin A, vitamin C, vitamin B6, dietary fiber, calcium and potassium.
It was found those who eat grapes also eat more of other fruits, vegetables, whole grains, nuts and seeds than non-consumers. They also consumed less added sugar, total fat, saturated fat and cholesterol.
Jean-Mari Peltier, Executive Director of the National Grape and Wine Initiative said, “It reinforces the association between grapes and a healthier diet, which is good news for consumers. Grapes, raisins and 100% grape juice are all foods that people enjoy eating, and this information adds another dimension to the grape and health story.”
Grapes are part of the berry family that have been eaten as food for over 2000 years. A three-quarter cup serving of grapes (red, green, or black) provides 90 calories, 23 g total carbohydrates, 1 g dietary fiber, and 20 g sugar. A one-quarter cup serving of raisins provides 120 calories, 1 g protein, 32 g total carbohydrate, 2 g dietary fiber, and 24 g sugar. Eight fluid ounces of 100 percent grape juice contains 150 calories, 1 g protein, 37 g total carbohydrate, and 36 g sugar.
Grapes, raisins, and grape juice also contain a wide variety of polyphenols, which may have beneficial effects on health. The biomedical effects of grape products have recently been reviewed and include modulating endothelial function, delaying low-density lipoprotein (LDL) oxidation, lowering blood pressure, and reducing oxidative stress, along with having beneficial effects on immune markers and cognition.
The dietary pattern reported by grape eaters in this study is similar to the pattern recommended by current dietary guidelines which include increased intakes of fruit and vegetables, especially dark green and orange vegetables, and reduced intakes of sodium, fat, added sugars, and calories from solid fats and added sugars. Fruit product intake has previously been associated with healthier dietary patterns. Significantly higher scores on the 2005 Healthy Eating Index have been associated, for instance, with 100 percent orange juice consumption by children and dried fruit consumption by adults.
Grapes are America’s number one specialty crop. The National Grape and Wine Initiative focuses on research and extension to strengthen the US grape and grape product industries in partnership with academics and government.

Impact Of Climate Change On Marine Life Analyzed By International Research Team

redOrbit Staff & Wire Reports – Your Universe Online

Global warming is forcing marine species to alter their breeding times and shift their geographic distribution towards the poles, according to new research published in this month’s edition of the journal Nature Climate Change.

The study comes from an ongoing research project, in which researchers from 17 international institutions are conducting a three-year global meta-analysis of the impact of climate change on marine systems.

Their project, which has been funded the National Center for Ecological Analysis and Synthesis (NCEAS) in California, has discovered that marine species are traveling towards the poles at a far faster rate than their land-based counterparts.

“This is the first comprehensive documentation of what is happening in our marine systems in relation to climate change,” former Nobel Prize recipient Camille Parmesan, the National Marine Aquarium Chair in Public Understanding of Oceans and Human Health within Plymouth University’s Marine Institute and one of the lead authors of the new study, said in a statement.

She added the research provided a “simple, but important message…What it reveals is that the changes that are occurring on land are being matched by the oceans. And far from being a buffer and displaying more minor changes, what we’re seeing is a far stronger response from the oceans.”

Parmesan and her colleagues compiled a database of more than 1,700 changes in marine life from international peer-reviewed scientific journals and other literature in order to analyze the impact of climate change. They discovered 81 percent of all changes could be directly linked with global warming.

They also discovered the so-called “front line” marine species such as phytoplankton and bony fish are moving towards the poles at an average rate of more than 44 miles (72 kilometers) per decade. In comparison, terrestrial creatures are moving pole-ward at an average rate of less than four miles (six kilometers) per decade, even though sea surface temperatures are warming three times slower than land temperatures.

The report will form part of the Fifth Assessment Report United Nation’s Intergovernmental Panel for Climate Change (IPCC), which is due for publication in 2014. The IPCC, which is based in Geneva, Switzerland assesses scientific, technical and socioeconomic data related to climate change, its potential effects, and possible adaptation and mitigation strategies.

“The effects of climate change on marine species have not been a major focus of past IPCC reports because no one had done the work to pull together all the disparate observations from around the world,” said UCSB scientist Carrie Kappel. “This study provides a solid basis for including marine impacts in the latest global accounting of how climate change is affecting our world.”

“Our research has shown that a wide range of marine organisms, which inhabit the intertidal to the deep-sea, and are found from the poles to the tropics, have responded to recent climate change by changing their distribution, phenology or demography,” added Dr. Pippa Moore, a lecturer in aquatic biology from Aberystwyth University. “These results highlight the urgent need for governments around the globe to develop adaptive management plans to ensure the continued sustainability of the world’s oceans and the goods and services they provide to human society.”

JAXA Rocket Carrying KIROBO Robot Departs For Space Station

redOrbit Staff & Wire Reports – Your Universe Online

A Japan Aerospace Exploration Agency (JAXA) spacecraft carrying supplies, food, experiment hardware and one pint-sized talking robot has begun its weeklong journey to the International Space Station (ISS) after lifting off from the Tanegashima Space Center on Saturday afternoon.

According to NASA officials, the fourth JAXA H-II Transfer Vehicle (HTV-4) launched from the facility, which is located in southern Japan, at 3:48pm EDT Saturday (4:48am Sunday local time). Also known as Kounotori or “white stork” because it is transporting an important delivery, HTV and its 3.5 ton payload launched aboard an H-IIB launch vehicle en route to the ISS, which was flying 260 statute miles over southwest Russia at the time of departure.

In addition to carrying drinking water, food, clothing and work supplies for the Expedition 36 crew members currently stationed onboard the facility, HTV-4 will be delivering new hardware for NASA’s Robotic Refueling Mission (RRM) – an initiative designed to demonstrate and test the tools, technologies and techniques needed to robotically service and refuel satellites in space.

The agency hopes that RRM will lay the foundation for future robotic servicing missions in microgravity, and the hardware currently en route to the ISS will allow RRM to be outfitted in order to practice a new set of satellite-servicing activities. Among those activities is a 2014 demonstration of how space robots can help replenish the refrigerant cryogen in the instruments of older satellites that were not originally designed to be serviced.

Also making the journey to the space station is KIROBO, a 13-inch tall humanoid robot programmed to communicate in Japanese. As reported last month by redOrbit.com’s own Lee Rannals, KIROBO is accompanying Japanese astronaut Koichi Wakata, and is programmed to remember his face and to keep records of its conversations with him.

KIROBO – which is equipped with speech recognition, natural language processing, speech synthesis, information communication, facial recognition and recording technology – is also expected to play a role in some ongoing ISS missions. It is expected to relay messages from the control room to the astronaut. The communication test between the robot and Wakata is reportedly scheduled to begin in November.

According to BBC News, the project “is part of a study to see how machines can lend emotional support to people isolated over long periods.” The robot, whose name is a portmanteau of the Japanese words for “hope” and “robot,” underwent dozens of tests over the past nine months to ensure that it was compatible with space and able to reliably perform its tasks on the ISS. A twin robot, MIRATA, will be stationed on Earth and will keep tabs on KIROBO, the British news agency added.

HTV-4 is expected to reach and dock with the space station on August 9, according to AFP reports. The vehicle is also delivering test samples for research experiments inside the Kibo laboratory, a new freezer capable of preserving materials at temperatures below -90 Fahrenheit, and four small CubeSat satellites to be deployed from Kibo’s airlock, NASA said.

Hubble Finds Fireball Following Gamma Ray Burst

redOrbit Staff & Wire Reports – Your Universe Online

Researchers using the Hubble Space Telescope have discovered new evidence that the merger of two small, super-dense stellar objects is responsible for producing short-duration gamma ray bursts, according to research published Saturday in a special online edition of the journal Nature.

Thanks to observations provided using NASA’s low-orbit aperture telescope, the study authors were able to locate a new type of stellar blast known as a kilonova, which they say results from the energy released after two compact objects crash into one-another.

Hubble observed the fading fireball from one of these events last month, following a short gamma ray burst (GRB) in a galaxy almost 4 billion light-years from Earth, they explained. Experts had predicted that a kilonova would accompany a short-duration GRB, but this was the first time the phenomenon had been witnessed.

“This observation finally solves the mystery of the origin of short gamma ray bursts,” lead researcher Nial Tanvir of the UK’s University of Leicester said in a statement.

“Many astronomers, including our group, have already provided a great deal of evidence that long-duration gamma ray bursts (those lasting more than two seconds) are produced by the collapse of extremely massive stars. But we only had weak circumstantial evidence that short bursts were produced by the merger of compact objects,” he added. “This result now appears to provide definitive proof supporting that scenario.”

The kilonova, which has been dubbed the “smoking gun” evidence supporting the theory that the short-duration bursts are caused by the merger of stellar objects such as a pair of neutron stars, is said to be approximately 1,000 times brighter than a nova caused by the eruption of a white dwarf.

Astrophysicists had predicted that this type of GRBs were created when a pair of super-dense neutron stars in a binary system spiral together, and during the final few milliseconds during which they merge, they eject highly radioactive material. That material, the researchers explain, heats up and expands, emitting a burst of light.

The resulting kilonova emits roughly as much visible and near-infrared light every second as the Sun does every few years, and lasts for approximately one week. Recently, researchers Jennifer Barnes and Daniel Kasen of the University of California, Berkeley, and the Lawrence Berkeley National Laboratory published a study describing how kilonovas should look.

An unexpected chance to study their hypothesis came on June 3, when NASA’s Swift mission detected an extremely bright gamma-ray burst, (GRB 130603B) in a galaxy located nearly four billion light-years away. While the initial blast of gamma rays lasted just one-tenth of a second, investigators report that it was approximately 100 billion times brighter than the kilonova flash that followed.

“We quickly realized this was a chance to test Barnes’ and Kasen’s new theory by using Hubble to hunt for a kilonova in near-infrared light,” Tanvir said. They calculated that the light would be at its brightest in near-infrared wavelengths about three to 11 days after the initial event, so they quickly requested permission to use Hubble’s Wide Field Camera 3 to search for the location of the initial burst. One June 12-13, they spotted a faint red object, and subsequent observations three weeks later confirmed that it had faded away and was likely a fireball from the blast.

“Previously, astronomers had been looking at the aftermath of short-period bursts largely in optical light, and were not really finding anything besides the light of the gamma-ray burst itself,” explained researcher Andrew Fruchter of the Space Telescope Science Institute (STSCI). “But this new theory predicts that when you compare near-infrared and optical images of a short gamma-ray burst about a week after the blast, the kilonova should pop out in the infrared, and that’s exactly what we’re seeing.”

Symptoms of Lupus

Lupus is a complex disease. The key to treating lupus is early diagnosis; however, the symptoms of lupus are the same as other diseases. In the medical community, lupus is known to be a great imitator. Its similarities to other diseases often lead to misdiagnosis. If you are suffering from any of the symptoms below, make sure to consult a doctor and report all the symptoms that you have felt. The most common symptoms of lupus are:

  • Fatigue
  • Joint/muscle aches or pains
  • Feverishness
  • Appearance of rashes
  • Weakness
  • Weight gain/loss.

While lupus is higher in women than in men, men can still be diagnosed by lupus. There are slight differences when lupus manifests for both genders. Here are the symptoms of lupus manifested in different parts of the body.

Lupus Symptoms

  • Central Nervous System (CNS) – Symptoms are the same for both genders. Patients suffer from seizures, paralysis, neuropathies like myasthenia gravis (abnormal weakness of the muscles), psychiatric disorders like clinical depression, and migraines.
  • Blood – Decreased platelets and increased or abnormal autoantibodies are often observed.
  • Musculoskeletal – Patients may suffer from arthritis and myalgia or muscle pain. Arthralgia or joint pain is also common.
  • Skin – Discoid lesions or sores that inflame and eventually scar appear on the face, mouth, and ears for both men and women. Both genders also experience baldness, butterfly rash, photosensitivity, and Raynaud’s syndrome, a condition where the blood vessels narrow when a patient feels cold or stressed causing the affected area to turn blue. In men, ulcers appear on the nose and mouth while women experience it in the nose, mouth, and genitals.
  • Gastrointestinal tract – Patients with lupus also have reduced appetite and diarrhea. Vomiting has also been observed.
  • Kidney – With lupus nephritis, the kidney becomes severely affected. Reduction in the amount of urine, unexplained shortness of breath, edema or the swelling of the ankles, legs, and feet, and persistent nausea are some of the signs. During testing, high amounts of protein are found in the urine.
  • Eye – There are small white or yellowish white deposits in the retina. The eyes are also very dry, and conjunctivitis is common.
  • Tissues – Patients can experience pericarditis or inflammation of the lining surrounding the heart, endocarditis where the inner lining of your heart chambers are infected, and pleurisy, where the inner linings of the heart are inflamed.
  • Lymph Nodes – The liver and the spleen are enlarged. Symptoms often include loss of appetite and discomfort or pain on the upper left side of the abdomen.

When you report these symptoms to your doctor, they will do several tests to confirm the diagnosis. Because lupus has periods of flares and wellness, routine blood tests are essential. Doctors request for routine blood tests and antibody blood tests. Antibody blood tests test for antinuclear antibodies (ANA).  In 97% of lupus patients, ANA tests positively. Other tests include urine testing, tissue biopsies, and blood clotting time tests. Even when diagnosed, routine screening is vital in managing lupus. Some of the treatment available to lupus patients have side effects that can damage the organs.

References:

https://resources.lupus.org/entry/common-symptoms

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108835/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602487/

https://www.webmd.com/digestive-disorders/enlarged-spleen-causes-symptoms-and-treatments#2

https://resources.lupus.org/entry/lab-tests

Causes of Lupus

The exact cause of lupus is still unknown. Researchers have explored hormones, genetics, and environmental triggers as the culprit for lupus. Recently, research has also focused on epigenetics or the role of the environment in activating specific genetic markers.

These possible causes are examined in detail below.

Hormones

About nine out of ten cases of lupus are of women. Lupus also manifests in women during the child-bearing age. Hormones are said to be the leading cause of lupus in women. The onset of menstruation until pre-menopause is said to expose women to high estrogen levels. Lupus also flares mostly before menstrual periods and during pregnancy. Still, some other studies suggest that it’s not just hormones but sex as well. The female X chromosome carries CD40 which contributes to the development of lupus. Patients also experience more flares during pregnancy and researchers still have not discovered whether estradiol or progesterone cause this.

Genetics

Studies on what specific genes set off lupus are still ongoing. There may be around 50 to 100 genes that make you susceptible for lupus. In identical twins where one has developed lupus, the remaining twin has a 30% chance of getting it too. If you have a family member or relative who has lupus, your risk is 10% higher especially if other members of the family have other autoimmune diseases.

People of color are also at higher risk of getting lupus. African-Americans, Asians, Hispanic/Latino, Native Americans, native Hawaiians, and Pacific Islanders might share similar genes that predispose them to lupus. It has also been observed that some lupus patients come from more diverse backgrounds although the link is not established.
Epigenetics can also explain why some people who have higher risks for lupus never really develop it especially in the case of identical twins.

Environment

Some environmental factors are known to activate flares. It follows that these environmental agents are investigated too, but there is no definite link established yet. If someone who is predisposed to lupus is in an environment that has known triggers, their chances of manifesting the disease are certainly higher. Here are some environmental agents:

  • UV rays both from artificial and natural light can elicit skin rashes and lesions of susceptible people.
  • Cigarette smoking has a link to lupus and other autoimmune diseases. Smoking is thought to damage DNA and increase anti-dsDNA antibodies, responsible for attacking the body’s own cells.
  • Exposure to certain substances like silica, solvents, pesticides, and heavy metals. Although it’s not yet clear how exactly they trigger lupus, silica has been linked to the increase of pro-inflammatory cytokines.

Others

Drug-induced lupus is normally caused by drugs like hydralazine, minocycline, quinidine, chlorpromazine, methyldopa, and minocycline to name a few. Unlike SLE, symptoms for drug-induced lupus disappear when the patient stops taking the drugs.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728979/

https://www.ncbi.nlm.nih.gov/books/NBK459474/

https://www.webmd.com/lupus/understanding-lupus-prevention#1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965307/

https://resources.lupus.org/entry/what-causes-lupus

What is Lupus?

What is lupus? It’s something you might be wondering after watching any episode of House, M.D where the doctors spend their time arguing back and forth over whether something is or isn’t lupus. Or you may be worrying that you yourself might be suffering from the condition.

Well, either way, there’s a lot we know about lupus, and a lot we don’t know. But let’s look at some of the basic details to figure out what is lupus, what the signs and symptoms are, and what you can do to treat it.

What Is Lupus?

Lupus is a chronic condition where the body essentially attacks its own tissue. You see, lupus is something called an autoimmune disorder, which is a condition where the immune system begins to treat the cells of the body as if they were a foreign pathogen.

In a healthy immune system, white blood cells attack and destroy invading cells from viruses or bacteria. But in someone with an autoimmune disorder, these cells attack the other, healthy cells of your body instead. No one is completely sure why this happens in someone with lupus, but it seems to have something to do with a combination of genetics and environment.

For starters, we know that there’s a connection with genetics and lupus. People with lupus often have family members who have the condition, and the fact that almost 90% of lupus patients are women definitely suggests a genetic component.

And as for the environment, lupus is often triggered by something that a patient is exposed to. A significant proportion of lupus cases happens after the patient suffers from a serious episode of bacterial infection. That implies that the immune system of someone genetically predisposed to lupus is triggered into a hypersensitized state by that infection.

And in addition, a lot of cases of lupus are caused by exposure to certain medications, primarily anti-seizure medications.  And in these patients, lupus often goes away after they stop taking the medication. So that implies that for some people, lupus symptoms can be created entirely by external substances.

What Are The Symptoms?

The symptoms of lupus are generally consistent from patient to patient, but the severity of lupus can vary pretty significantly. Lupus can do damage to the cells of the heart, lungs, kidneys, and nearly every other organ. This usually leads to those tissues becoming swollen or inflamed. And that results in painful joints and swollen limbs, which makes moving difficult for lupus patients.

Skin issues are also quite common among people with lupus. And one of the most obvious signs that doctors look for when diagnosing lupus is a distinctive butterfly-shaped rash across the face of lupus patients. In addition, people with lupus often develop painful sores in the mouth.

In the worst cases of lupus, the damage caused to the body can even be fatal. Because lupus causes tissue damage, it can begin to destroy important organs. The heart can become swollen and scarred, which makes it harder for it to pump blood through the body. The kidneys can also begin to shut down, which leaves your body unable to filter out toxins. And the red blood cells that carry oxygen to the brain are often damaged by lupus, which is also life-threatening.

However, most people don’t experience such severe lupus, and lupus can be treated and managed in most patients.

How Is It Treated?

For most lupus patients, it’s perfectly possible to live a normal, productive life. There is no cure for lupus, but there are things you can do to make it manageable.

To begin with, adopting a healthy lifestyle will make your lupus symptoms less severe. Avoid processed foods and get plenty of exercise. Focus on maintaining as positive an attitude as you can. These simple changes can actually make a big difference in managing your lupus.

As far as medications go, most doctors prescribe anti-inflammatory drugs. This class of drugs reduces the amount of inflammation in people with lupus, which helps restore some of their mobility and also reduces the amount of pain they experience. In addition, your doctor might try a corticosteroid which is designed to do the same thing and reduce the amount of swelling in your tissue.

And while there is currently no cure for lupus, research into the condition is continuing and making strides every day. If you would like to contribute to the fight against lupus, you can donate to the Lupus Foundation of America a which works to raise awareness of lupus and fund research with charitable events.

So what is lupus? Lupus is an autoimmune disorder that impacts many peoples’ lives. But there is something you can do to fight back. Help raise lupus awareness and contribute funds to research. Together we can make a difference.

More Bears Are Now Using Banff Highway Crossings

Susan Bowen for redOrbit.com – Your Universe Online
Anywhere that cars and wildlife occupy the same area, the potential for dangerous interactions between the two exists. Additionally, a highway that prevents large animals from crossing successfully to other parts of their range can seriously disrupt wildlife habitat.
Banff National Park has worked hard since the 1990’s to decrease these problems along the highly-traveled, 83-km stretch of the Trans-Canada Highway that runs through the park. New research, published in the journal Conservation Biology, shows that their efforts have been a success.
There are 25 wildlife crossing structures in the park; two are overpasses and the rest are bridges or culverts. The overpasses are wide and covered with enough vegetation to resemble the surrounding forest. These work in conjunction with high fencing installed along the roadways. The fencing itself “has reduced wildlife-vehicle collisions by more than 80% and, for elk and deer alone by more than 96%,” according to the Parks Canada website.
Study participant Tony Clevenger, an Alberta-based wildlife biologist, explains the purpose of the research. “This is a landmark study because it’s the first time anyone has done extensive genetic sampling to address unanswered questions about the use of highway crossings by bears. We knew that bears used the crossings, we just didn’t know how many, what percentage of each species’ population uses them, whether there is a preference by males or females to use crossings, and if there was a gender or species preference for overpasses or underpasses.”
In the course of their three year study, Clevenger and his fellow researchers Mike Sawaya and Steven Kalinowski, both of Montana State University, proved that the structures are doing their job of allowing animals to safely use all parts of their habitat. This is particularly important for the threatened Alberta grizzly bear population.
The researchers set out non-invasive hair snags to provide material for genetic testing. They recovered snagged hair from 20 crossings strung with barbed wire, 420 baited hair traps and 497 rub trees with wires attached. They were able to collect 10,000 hair samples. The team identified 15 individual grizzly bears and 17 individual black bears, meaning that 20 percent of Banff’s bears used the crossings. They have also determined that bears are able to use the crossing structures to find mates on the other side.
Sawaya said that their research shows that there is sufficient connectivity to maintain a healthy ecosystem for bears and other large mammals. Clevenger explained that the study’s findings are a breakthrough. “This is confirmation of what our previous investigations have suggested but couldn’t confirm. We were pretty certain that the numbers of bears using the crossings had steadily increased. Now we know.”
Parks Canada adds, “There is a ‘learning curve’ for animals to begin using wildlife crossings after construction. For wary animals like grizzly bears and wolves, it may take up to five years before they feel secure using newly built crossings. Elk were the first large species to use the crossings, even using some while they were under construction!”
In all, eleven species of large mammals have been recorded using wildlife crossings more than 143,000 times since 1996. This includes grizzly and black bears, wolves, coyotes, cougars, moose, elk, deer, bighorn sheep, and more recently, wolverine and lynx.
The study showed that grizzly bears, elk, moose and deer prefer wildlife crossings that are high, wide and short in length, including overpasses. Black bears and cougars seem to prefer long, low and narrow crossings.
The Banff example is being copied in other places. The Montana Department of Transportation has installed more than 40 wildlife crossings where US Highway 83 passes through prime grizzly habitat on the Flathead Indian Reservation. The Western Transportation Institute (WTI) is studying these crossings to access their success in improving habitat. Rob Ament, manager of WTI’s Road Ecology Program said that the research in Banff and Flathead is fundamental to providing solutions to transportation in the rural west, where wildlife-vehicle collisions are common. He concludes, “Between Banff and the U.S. 93 project, we’re talking about the two largest wildlife mitigation projects for highways in North America, if not the world. The lessons we learn will be shared with transportation practitioners not only here in the United States but also with those around the globe.”

Can You Stomach This? Starfish Feeding Secrets Revealed

[ Watch the Video: Starfish Feeding Mechanism Better Understood ]

Brett Smith for redOrbit.com – Your Universe Online

Starfish have a feeding method that is unlike any other. To eat, the echinoderm ejects its stomach from its own body — placing it over the digestible parts of its prey, typically a mussel or clam. The stomach then partially digests what it can, producing a chowder-like slurry that is then drawn back into the starfishes’ ten digestive glands.

According to a new report in The Journal of Experimental Biology, UK scientists have identified a particular signaling molecule responsible for drawing the stomach back into the starfish’s body.

“These findings open up the possibility of designing chemical-based strategies to control the feeding of starfish,†said study co-author Maurice Elphick, professor of physiology and neuroscience at Queen Mary, University of London.

Humans are constantly competing with starfish for tasty treats at the bottom of the sea, and the study’s findings could lead to a fairly non-invasive and humane way to control the starfish population.

“Starfish predation has an economic impact, as they feed on important shellfish such as mussels and clams,” Elphick said. “Periodic increases in starfish populations can also cause major destruction to Pacific reef tracts, such as the Great Barrier Reef, since certain species feed on reef-building corals.”

Starfish are notorious for ravaging the fragile ecosystems of coral reefs. If the world’s reefs become heavily affected by climate change as many predict, scientists may need to consider every tool at their disposal for maintaining these rich sources of biodiversity.

Using DNA sequencing and chemical analysis of starfish nerves, along with other tests, the researchers were able to identify the key neuropeptide used in their stomach retraction.

“Interestingly, we have also found that the neuropeptide behind the stomach retraction is evolutionarily related to a neuropeptide that regulates anxiety and arousal in humans,” Elphick said.

The discovery builds on previous research from the same team that found neuropeptides called SALMFamides that cause the starfish stomach to relax and flip inside-out before being sent outside the body.

In addition to having an unusual feeding technique, starfish also have a bizarre way to ‘see’ the environment around them. In a study released last month, researchers have found new details about how starfish use primitive eyes that are located at the tip of each arm.

While marine biologists have known about these eyes for some time, it wasn’t clearly understood how they worked.

In the study, the scientists placed starfish with and without eyes near a coral reef and watched to see how they would navigate toward it. While the starfish without eyes meandered aimlessly, those with eyes made their way directly to the reef.

“The results show that the starfish nervous system must be able to process visual information, which points to a clear underestimation of the capacity found in the circular and somewhat dispersed central nervous system of echinoderms,” said Anders Garm, a biologist at the University of Copenhagen who worked on the study.

The researchers noted that the starfish eyes resemble those of crabs and spiders, containing simple photoreceptors that sense or receive light.

Bullied Kids May Become Career Criminals

April Flowers for redOrbit.com – Your Universe Online

Individuals who suffered repeated bullying throughout their childhood and adolescence are significantly more likely to go to prison than people who did not, according to a new study presented at the American Psychological Association’s (APA) 121st Annual Convention on August 1 in Honolulu, Hawaii.

The study, conducted by Michael G. Turner, PhD, of the Department of Criminal Justice and Criminology at the University of North Carolina, Charlotte, revealed almost 14 percent of those who reported being bullied repeatedly from childhood through their teens ended up in prison as adults. This is compared to six percent of non-victims, nine percent of childhood-only victims, and seven percent of teen-only victims.

Turner also compared conviction rates, finding more than 20 percent of those who endured chronic bullying were convicted of crimes, compared to 11 percent of non-victims, 16 percent of childhood victims, and 13 percent of teen victims. Non-white childhood victims had significantly lower odds of serving prison time than white childhood victims, according to Turner’s analysis.

“Previous research has examined bullying during specific time periods, whereas this study is the first to look at individuals’ reports of bullying that lasted throughout their childhood and teen years, and the legal consequences they faced in late adolescence and as adults,” said Turner.

Among other findings, the study revealed women who suffered chronic bullying from childhood through their teens had significantly higher odds of using alcohol or drugs, and of being arrested and convicted than men who had also suffered long-term chronic bullying.

For the study, Turner analyzed data collected by the US Department of Labor and the Bureau of Justice Statistics during the 1997 National Longitudinal Survey of Youth. The participant cohort consisted of 7,335 individuals between the ages of 12 and 16 as of Dec. 31, 1996, and reflected the demographics of the US at the time.

Four groups were identified by the analysis: non-victims (74 percent); those bullied repeatedly before the age of 12 (15 percent); those bullied repeatedly after the age of 12 (6 percent); and those repeatedly victimized before and after the age of 12 (5 percent). The survey collected accounts of repeated bullying over several periods and the legal outcomes were assessed when participants’ were in their late teens or adults. The relationships between bullying and legal outcomes were examined across gender and race, as well. The participants were followed over a 14-year time period, starting in early adolescence and ending in adulthood.

Turner believes his findings will be significant for medical professionals.

“This study highlights the important role that health care professionals can play early in a child’s life when bullying is not adequately addressed by teachers, parents or guardians,” Turner said. “With appropriate questions during routine medical checkups, they can be critical first points of contact for childhood victims. Programs that help children deal with the adverse impacts of repeated bullying could make the difference in whether they end up in the adult legal system.”

Recent Devastating Wildfires Could Be Result Of Climate Change

redOrbit Staff & Wire Reports – Your Universe Online

The larger, more destructive wildfires devastating some regions of the western US could be fueled by climate change, according to new research appearing in the Journal of Applied Meteorology and Climatology.

These erratic fires are more difficult to contain, as well as more dangerous to people living in the area and likely to cause catastrophic damage, lead author and Michigan State University assistant professor of geography Lifeng Luo and his colleagues said.

Furthermore, they predict the trend is likely to continue.

As Luo said Thursday in a statement, “Our findings suggest that future lower atmospheric conditions may favor larger and more extreme wildfires, posing an additional challenge to fire and forest management.”

Using multiple regional climate models, the study authors studied both current and future climate patterns and their impact on the spread of fire in the mountainous region that includes Arizona, Idaho, Nevada, New Mexico, Utah and Wyoming.

They focused their efforts on the month of August, which is the most active time period for wildfires in the western US. They discovered 3.6 million acres burned in the area during August 2012 – more than any August in a dozen years. However, there were only 6,948 fires last August – the second fewest since 2000. That means the fires were much larger than usual.

The increased size of the wildfires is mainly driven by natural factors, such as the availability of fuel (vegetation), precipitation, wind and the location of lightning strikes, the researchers explained. Specifically, they found extremely dry and unstable conditions in the earth’s lower atmosphere will continue contributing to “erratic and extreme fire behavior.”

Furthermore, Luo and co-authors Ying Tang and Shiyuan Zhong from Michigan State, and Xindu Bian and Warren Heilman from the US Forest Service also wrote, “global climate change may have a significant impact on these factors, thus affecting potential wildfire activity across many parts of the world.”

In related news, research published earlier this month in the journal Nature Communications revealed wildfires could be playing a greater role in global warming than experts had previously believed. In fact, the study revealed carbonaceous aerosols produced during the massive 2011 Las Conchas fire in New Mexico could have been quite different from those featured in current computer simulations.

As a result, the information provided by those computer climate models could be inaccurate. Based on their findings, the study authors believe that scientists need to establish a framework to include a realistic representation of these carbon-containing particles in climate models. Furthermore, they suggest that wildfire emissions could contribute far more to global warming trends than current estimates suggest.

New Mars Express Images Show Craters Once Filled With Water

Brett Smith for redOrbit.com – Your Universe Online
Newly released images from the European Space Agency (ESA) show how water and other natural forces shaped craters and other surface features on Mars.
According to a statement from the space agency, the craters shown were once filled with sediments and water. Only traces of their history can now be found in the Martian desert.
The images, snapped on January 15 by ESA’s Mars Express orbiter, show a swath of the red planet just a few degrees south of the equator. The unnamed region sits slightly to the north of a dried out riverbed, dubbed Tagus Valles, and east of Tinto Valles and Palos crater, which were both featured in previous Mars Express photo sets.
One particular 21-mile-wide crater featured in the images contains several large, flat-topped blocks called mesas located next to parallel wind-blown features called yardangs. Both features appear to be carved from sediments that originally sat in the crater, most likely deposited there during a flood that covered the entire region, the agency said. After large amounts of sediment were eroded away, only the odd-shaped pattern of stronger blocks remained.
Hints of a watery past can also be seen in the remnants of an ancient crater located about 12 miles to the east. While the crater has almost completely disappeared, a long winding channel clearly ‘flows’ directly into what remains.
The crater remains also show evidence of several landslides, potentially due to water eroding the crater walls. Ruts run down the crater’s inner walls to where large piles of material have accumulated around the crater floor.
One group of interconnected craters in the images has flat floors that have been smoothed over by sediments. A smaller crater in the group contains a prominent debris residue called an ejecta blanket.
An ejecta blanket is formed after a meteor strikes a planetary surface and the excavated material forms a symmetrical apron around the crater. The ejecta blanket featured in the latest Mars Express image is referred to as a rampart, which has “petal-like lobes around its edges” formed by ejected water that allowed debris to flow along the surface, the ESA said.
The new Mars images also show evidence of volcanic activity shaping the region. A dark, fine layer of ash in one of the images may have come from the Elysium volcanic region, the ESA said. Over the millennia, pockets of buried volcanic material were exposed by erosion and the ash was spread around by wind.
Meanwhile, NASA’s Curiosity rover is about to complete its first full year on Mars and is currently in the middle of a long voyage toward Mount Sharp. The Curiosity team has said they hope to find more evidence of Mars’ watery past at the base of the 3.4-mile-high mountain. However, the NASA scientists say there are not in a rush to get there and the journey could take a year or longer, depending on how many interesting stops they find along the way.

Scientists Develop Breathalyzer That Can ‘Smell’ Infection

Brett Smith for redOrbit.com – Your Universe Online
No longer the sole the domain of law enforcement, breathalyzers are being used more and more by scientists who want a faster, less invasive way to assess patients.
According to a new report in the open-access journal PLOS ONE, researchers from University of California, Irvine have developed breathalyzer technology capable of determining the severity of bacterial and other infections.
In the study, the California researchers worked with a method originally developed to analyze air pollution. They used it to associate levels of inflammation in mice with naturally produced levels of carbon monoxide in breath.
“Breath analysis has been showing promise as a diagnostic tool in a number of chronic diseases,” said study author Dr. Alan Barbour, a professor of microbiology, molecular genetics and medicine at UC Irvine. “This study provides the first evidence…that it can be used for rapid clinical assessment of infections, which can lead to prompt institution of effective treatments.”
The air pollution method was originally developed by chemists at UC Irvine, and Barbour wanted to see if the technique could be used to detect low-level biomarkers that are the product of a body’s inflammatory response to infection. While these biomarkers can be detected in the blood, the research team decided to see if a breathalyzer could be developed, creating a less invasive test.
The scientists used mice with bacterial blood infections to refine their technology. They found that higher levels of infection correlated to higher carbon monoxide-to-carbon dioxide ratios in breath samples. Carbon monoxide returned to normal soon after the mice were given an antibiotic, showing that carbon monoxide is a dependable indicator of infection.
“Using a breath analysis method like this could help physicians in the emergency room and ICU make critical decisions about serious infections more quickly than if they had to wait for blood tests to come back from the lab,” Barbour said.
The UC Irvine scientist said that he plans to begin testing the technology using human breath samples and subjects.
Scientists in Japan recently announced a different spin on the breathalyzer concept – using it to determine if exercisers are beginning to burn fat.
Acetone levels in the blood rise when the body breaks down fat and the experimental device is designed to show when this excess acetone makes its way from the blood into the lungs and out as breath. After breathing into the device for ten seconds, the results of the breathalyzer are sent to a smartphone via Bluetooth or a cable connection.
Earlier this year, researchers in Sweden announced they had expanded on the most prevalent use of breathalyzers and designed one capable of detecting the presence of 12 different drugs in human breath. The device is able to pick up hints of marijuana, cocaine, opiates and methamphetamines with 87 percent accuracy.
While that level of accuracy might not be enough to warrant a conviction in court, the device in its current state could be used for roadside stops that could then be followed up with further testing back at a police station.

Citizen Scientists Rival Experts In Analyzing Land-Cover Data

Over the past 5 years, IIASA researchers on the Geo-Wiki project have been leading a team of citizen scientists who examine satellite data to categorize land cover or identify places where people live and farm. These data have led to several publications published in peer-reviewed journals.
“One question we always get is whether the analysis from laypeople is as good as that from experts. Can we rely on non-experts to provide accurate data analysis?” says IIASA researcher Linda See, who led the study published in the journal PLOS ONE.
The researchers compared 53,000 data points analyzed by more than 60 individuals, including experts and non-experts in remote sensing and geospatial sciences. The new study shows that non-experts were as good as experts at identifying human impact, a concept that has emerged from ecological sciences, in satellite land cover data.
However, the study showed, experts were better at identifying the specific land-cover types such as forest, farmland, grassland, or desert. When presented with control data where researchers knew the land-cover type, experts identified land cover correctly 69% of the time, while non-experts made correct classifications only 62% of the time. The researchers suggest that interactive training and feedback could help non-experts learn to make better classifications and continue to improve these numbers in the future.
“Citizen science has actually been around for a very long time in many different guises,” says See. “But as the internet continues to proliferate in the developing world, and mobile devices and wearable sensors become the norm, we will see an explosion of activity in this area. Studies like this are critical for establishing the quality of data coming from citizens. What we need is more tools and techniques for helping us to continually improve this quality, and more partnerships with NGOs, industry, government and academia that actively involve and trust citizens.”

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Fear Factor For Fish: A Mix Of Robots And Alcohol

April Flowers for redOrbit.com – Your Universe Online

An international team of scientists has shown bio-inspired robots can not only elicit fear in zebrafish, but that this reaction can be modulated by alcohol. These findings, published in PLoS ONE, are the latest in a series of experiments designed to test the ability of robots to influence live animals.

The team hopes to pave the way for new methodologies for understanding anxiety and other emotions, as well as substances that alter them. With this study, Maurizio Porfiri, associate professor of mechanical and aerospace engineering at the Polytechnic Institute of New York University (NYU-Poly) and Simone Macri, a collaborator at the Istituto Superiore di Sanita in Rome, Italy, expand their previous efforts to determine how bio-inspired robots can be employed as reliable stimuli to elicit reactions from live zebrafish. Zebrafish show a strong affinity for robotic members designed to swim and appear as one of their own, according to prior studies. Those same studies revealed this preference can be abolished by exposure to ethanol.

The team hypothesized bio-engineered robots could be used to induce fear as well. They designed a robot that mimicked the morphology and locomotion pattern of the Indian leaf fish, a natural predator of the zebrafish. In a three-section tank, the scientists placed zebrafish in one section, the robotic Indian leaf fish in another and left the third compartment empty. They found the control group avoided the robotic predator uniformly, showing a preference for the empty section of the tank.

The research team exposed separate groups of fish to different levels of ethanol in water to determine whether alcohol would affect fear responses. In humans, rodents and some species of fish, ethanol has been shown to influence anxiety-related responses. The team observed remarkable changes in behavior, (failing to avoid the predatory robot), in the zebrafish exposed to the highest concentrations of ethanol. No harm or lasting effects have been caused by acute administration of ethanol on zebrafish.

“These results are further evidence that robots may represent an exciting new approach in evaluating and understanding emotional responses and behavior,” said Porfiri. “Robots are ideal replacements as independent variables in tests involving social stimuli–they are fully controllable, stimuli can be reproduced precisely each time, and robots can never be influenced by the behavior of the test subjects.”

To ensure the zebrafish response to the robot was, in fact, a fear-induced response and to validate their findings, the team conducted two traditional anxiety tests and evaluated whether the results obtained therein were sensitive to ethanol administration.

Test subjects were placed in a two-chamber tank with one well-lit side and one darkened side, to establish which conditions were preferable. In another tank, the team simulated a heron attack from the water’s surface — herons also prey on zebrafish. They measured how quickly and how many fish took shelter from the attack. The fish strongly avoided the dark compartment. Most of them sought shelter very quickly from the attack. These responses were significantly modulated by ethanol exposure, abolishing the preference for the light compartment and significantly slowing the fishes’ retreat to shelter during the simulated attack.

“We hoped to see a correlation between the robotic Indian leaf fish test results and the results of the other anxiety tests, and the data support that,” Porfiri explained. “The majority of control group fish avoided the robotic predator, preferred the light compartment and sought shelter quickly after the heron attack. Among ethanol-exposed fish, there were many more who were unaffected by the robotic predator, preferred the dark compartment and were slow to swim to shelter when attacked.”

The scientists believe zebrafish could be suitable replacements for higher-order animals in testing for emotional responses. Their robotic approach would also reduce the number of live test subjects necessary for experiments and may inform other areas of inquiry, from collective behavior to animal protection.

Bigger Bird Brains Developed Before Dinosaurs Could Fly

[ Watch the Video: CT Scan of Albatross Brain ]

redOrbit Staff & Wire Reports – Your Universe Online

Feathered dinosaurs actually developed the larger brains needed for flight before actually taking to the skies, according to a new study published Wednesday in the journal Nature.

In the study, lead author Amy Balanoff, a research associate at the American Museum of Natural History and a postdoctoral researcher at Stony Brook University, and her colleagues, used CT scans to analyze the skulls of feathered but flightless dinosaurs.

They discovered “the reptiles’ brains were much more like that of Archaeopteryx, which is thought to be the first bird and lived 150 million years ago, than had been previously thought,” explained Richard Gray, Science Correspondent with The Telegraph. “It means these other flightless dinosaurs may have already taken key evolutionary leaps towards becoming modern birds by developing ‘flight ready brains.'”

The brains of birds can be distinguished from other creatures due to “hyperinflation,” meaning they are enlarged in comparison to the size of their bodies, the researchers said. This phenomenon is most obvious in the forebrain, which is vital for providing the enhanced vision and coordination required for flight.

However, researchers have been finding more and more evidence feathers, wishbones and other features once considered to be unique to modern birds actually first appeared in non-avian dinosaurs. Now, thanks to Balanoff’s team, scientists can now add the hyperinflated brain to that list.

Using CT scanners located at the Museum, Stony Brook University, University of Texas and Ohio University, the study authors were able to craft 3D reconstructions of more than two dozen specimens, including modern birds, the Archaeopteryx (one of the earliest known birds) and closely related non-avian dinosaurs.

As a result, they were able to calculate the total volume of each digital brain case, as well as determine the size of the cerebrum, the cerebellum, the optic lobes, and other major anatomical regions of the brain.

They discovered, in terms of volumetric measurements, the Archaeopteryx was not unique as a transitional species bridging the gap between non-avian dinosaurs and modern birds. In fact, Balanoff and her colleagues learned several other non-avian dinosaurs, including bird-like oviraptorosaurs and troodontids, actually had larger brains relative to their body sizes than the creature once believed to be the oldest known bird.

Archaeopteryx has always been set up as a uniquely transitional species between feathered dinosaurs and modern birds, a halfway point,” Balanoff told Gray. “But by studying the cranial volume of closely related dinosaurs, we learned that Archaeopteryx might not have been so special: If Archaeopteryx had a flight-ready brain, which is almost certainly the case given its morphology, then so did at least some other non-avian dinosaurs.”

Unfortunately for the Archaeopteryx, this is another blow to its once proud legacy, as Carl Zimmer of National Geographic pointed out on Wednesday. Once viewed as the “crucial fossil for scientists wanting to understand how reptiles evolved into feathered flyers,” Zimmer said its importance has been drastically reduced as more studies have been conducted and more fossils have been discovered by investigators.

For the past several decades, experts have agreed birds evolved from a suborder of bipedal saurischian dinosaurs known as theropods, but it has become increasingly uncertain exactly where Archaeopteryx fits into the equation, he said. It could still be closely related to the ancestors of modern birds, or there could be other non-flying theropods which share a closer genetic link with living avians.

“It’s possible that the common ancestor of Archaeopteryx and other close relatives of birds had already evolved a more bird-like brain than other dinosaurs. It’s also possible that the different linages of dinosaurs that were closely related to birds evolved even bigger brains in parallel,” Zimmer said.

“If a bird-like brain was essential for the mental challenge of flying through the air, then these other dinosaurs had what it took for flight,” he added. “It will be up to future paleontologists and ornithologists to figure out how flight shapes the brain, and how well other feathered dinosaurs could fly. But Archeopteryx will only be one among many species that they consider when they tackle those questions.”

Scientists Grow Human Ear In Lab From Animal Tissue

Lee Rannals for redOrbit.com – Your Universe Online
Scientists from Massachusetts General Hospital in Boston say they have grown a human-like ear from animal tissue in a lab.
The new ear, reported in the Journal of the Royal Society Interface, moves scientists one step closer to growing a complete human ear from a patient’s cells. The researchers say their ear has the flexibility of a real ear, and the technique may one day be used to help people with missing or deformed ears.
The scientists took living tissues from cows and sheep and grew them on a flexible wire frame that has the 3D shape of a real human ear. They then implanted the ear onto a rat whose immune system had been suppressed to enable the ear to grow.
“We’ve demonstrated the first full-sized adult human ear on the rat model,” Dr Thomas Cervantes, who led the study, told BBC News. “One – we were able to keep the shape of the ear, after 12 weeks of growth in the rat. And then secondly we were also able to keep the natural flexibility of the cartilage.”
Researchers grew the cells on a titanium wire scaffold that is modeled on the dimensions of a real human ear. The work shows that it is possible to grow enough cells to make a full-size human ear.
“In a clinical model, what we would do is harvest a small sample of cartilage, that the patient has, and then expand that so we could go ahead and do the same process,” Dr Cervantes told BBC. “This research is a significant step forward in preparing the tissue-engineered ear for human clinical trials.”
The researcher said he hopes the process could move into human clinical trial in about five years.
Last year doctors at John Hopkins Hospital were able to grow a replacement ear for a cancer patient on her own arm. The patient, Sherrie Walters, became the first person to receive a replacement ear developed from her own rib cartilage.
Walters developed basal cell carcinoma cancer, which led to the amputation of a portion of her left ear, skull and ear canal. The original procedure left her left side disfigured and deaf in her left ear. The doctors used cartilage from the rib cage to create a new ear that matched her right one. The ear was then implanted under the skin of her left forearm in November, where it grew for four months before being transplanted onto her head.

Breakthrough Snakebite Nasal Spray Could Save Thousands Of Lives

redOrbit Staff & Wire Reports – Your Universe Online

A team of California researchers has developed a novel approach to treating venomous snakebites by administering antiparalytics topically via a nasal spray, a breakthrough that could dramatically reduce the estimated 125,000 global snakebite fatalities each year.

The researchers, led by Dr. Matt Lewin of the California Academy of Sciences in collaboration with the Department of Anesthesia at the University of California, San Francisco, demonstrated the success of the needleless treatment during a recent experiment conducted at UCSF, the results of which were published last week in the journal Clinical Case Reports.

Snakebite is one of the most neglected of tropical diseases and there is often no easy way to treat victims in the field. An estimated 75 percent of snakebite victims who die do so because they don’t reach the hospital in time.

For a number of reasons, antivenoms are an imperfect solution. For example, even if the snake has been identified and the corresponding antivenom exists, venomous bites often occur in remote locations far from population centers. Furthermore, antivenoms are costly, require refrigeration and require significant expertise to administer and manage.

“In addition to being an occupational hazard for field scientists, snakebite is a leading cause of accidental death in the developing world, especially among otherwise healthy young people,” said Dr. Lewin.

“We are trying to change the way people think about this ancient scourge and persistent modern tragedy by developing an inexpensive, heat-stable, easy-to-use treatment that will at least buy people enough time to get to the hospital for further treatment.”

In his role as Director of the Academy’s Center for Exploration and Travel Health, Lewin prepares field medicine kits for the museum’s scientific expeditions around the world, and often accompanies scientists as the expedition doctor.

Two years ago, he assembled snakebite treatment kits for the Academy’s Hearst Philippine Biodiversity Expedition that would have required scientists to inject themselves if they needed treatment. But after seeing the team’s apprehension about the protocol, Lewin began to wonder if there might be a better way to treat snakebite in the field.

In some fatal snakebites, victims are paralyzed by the snake’s neurotoxins, resulting in death by respiratory failure. A group of common drugs known as anticholinesterases have been used for decades to reverse chemically-induced paralysis in operating rooms and, in intravenous form, to treat snakebite when antivenoms are not available or not effective. However, it is difficult to administer such IV drugs outside of a hospital setting, so Lewin began to explore the idea of a different delivery vehicle for these antiparalytics – a nasal spray.

In April of this year, Lewin and a team of anesthesiologists led by Dr. Philip Bickler at UCSF Medical Center designed and completed a complex experiment that took place at the university. During the study, a healthy human volunteer was paralyzed, while awake, using a toxin that mimics that of cobras and other snakes that disable their victims by paralysis. The experimental paralysis mimicked the effects of neurotoxic snakebite, progressing from eye muscle weakness all the way to respiratory difficulty, in the same order as is usually seen in envenomation. The team then administered the nasal spray and within 20 minutes the patient had recovered.

Later that month, while Lewin was giving the keynote address at the American Society for Clinical Investigation/Association of American Physicians meeting in Chicago, he discussed the experiment and its origins. The meeting gave Lewin the opportunity to meet Dr. Stephen Samuel, an Indian physician and scientist from Trinity College Dublin who was interested in collaborating with Lewin in India, where an estimated 1 million people are bitten by snakes every year, resulting in tens of thousands of deaths.

Lewin flew to India to help Samuel set up treatment protocols at a rural hospital in Krishnagiri. In June, Samuel, Dr. CS Soundara Raj and colleagues at TCR Multispeciality Hospital in Krishnagiri, Tamil Nadu, India treated a snakebite victim using the new protocol. The patient, a 50-year-old woman, was suffering from persistent facial paralysis from a krait bite, despite having undergone a full course of antivenom treatment. Upon treatment with the antiparalytic nasal spray, the facial paralysis was reversed within 30 minutes. Two weeks later, the patient reported having returned to her daily activities.

Lewin and his US colleagues are now conducting additional studies on mice to develop new methods and drug combinations, as there are many combinations of anticholinesterases and anticholinergic agents that could be used to make delivery of the drugs more predictable through the mucous membranes in the nose or eyes.

He is also working to set up future clinical studies with Samuel, Soundara Raj and their colleagues in India.

“We have to look into designing a product, maybe stock it in the local pharmacies throughout farming areas,” Samuel told Discover Magazine. “It’s not going to be a substitute for antivenom but it will buy time. It should save a lot of lives.”