Healthy Life Expectancy Highest In Hawaii, Lowest In South

redOrbit Staff & Wire Reports – Your Universe Online

Seniors living in Hawaii have the longest healthy life expectancy, while those living in the South, regardless of race, have the lowest, the CDC reported on Thursday in a state-by-state analysis of life expectancy for Americans 65 years of age.

Healthy life expectancy (HLE) is a population health measure that estimates the number of expected years of life in good health for people at a given age.

“Where you live in the United States shouldn’t determine how long and how healthy you live – but it does, far more than it should,” said CDC Director Tom Frieden.

“Not only do people in certain states and African-Americans live shorter lives, they also live a greater proportion of their last years in poor health. It will be important moving forward to support prevention programs that make it easier for people to be healthy no matter where they live.”

The CDC used 2007-2009 data from the National Vital Statistics Systems, US Census Bureau, and Behavioral Risk Factor Surveillance System to calculate HLEs by sex and race for each of the 50 states and Washington, DC, for all people 65 years of age.

The highest HLE was observed in Hawaii (16.2 years), while the lowest was seen in Mississippi (10.8 years).

HLE estimates for whites were lowest for seniors in Southern states. For blacks, HLE was comparatively low in all states and Washington, DC, with the exception of Nevada and New Mexico.

HLE was found to be greater for females than for males in all states, with the difference ranging from 0.7 years in Louisiana to 3.1 years in the Dakotas. For 65-year-old males, HLE varied between a low of 10.1 years in Mississippi and a high of 15.0 years in Hawaii, while HLE for 65-year-old females varied between a low of 11.4 years in Mississippi and a high of 17.3 years in Hawaii.

The CDC said HLE estimates can be used to predict future health service needs, evaluate health programs and identify trends and inequalities. Examining HLE as a percent of life expectancy can also reveal populations that might be enduring illness or disability for years.

SOFIA Airborne Telescope Heads South

Lee Rannals for redOrbit.com – Your Universe Online

NASA’s Stratospheric Observatory for Infrared Astronomy (SOFIA) telescope has moved south to New Zealand for the next two weeks to take advantage of the Southern Hemisphere’s orientation.

The space agency said the airborne observatory would be utilizing its southern position to take advantage of studying celestial objects that are difficult or impossible to see in the northern sky. SOFIA is a telescope attached to a modified Boeing 747SP aircraft with an effective diameter of 100 inches. It provides astronomers with visible, infrared and sub millimeter spectrum views of the night sky.

Astronomers used SOFIA on its first New Zealand flight to observe the disk of gas and dust orbiting the black hole at the center of our Milky Way galaxy. The airborne telescope was also able to take a peek at two dwarf galaxies and the Large and Small Magellanic Clouds. The Magellanic Clouds can be seen with the naked eye in the southern sky.

“SOFIA’s deployment to the Southern Hemisphere shows the remarkable versatility of this observatory, which is the product of years of fruitful collaboration and cooperation between the U.S. and German space agencies,” said Paul Hertz, director of NASA’s Astrophysics Division in Washington. “This is just the first of a series of SOFIA scientific deployments envisioned over the mission’s planned 20-year lifetime.”

Astronomers will be using a far-infrared spectrometer known as the German Receiver for Astronomy at Terahertz Frequencies (GREAT) mounted on SOFIA to study interstellar gas and the life cycle of stars.

“The success of the GREAT spectrometer in addressing exciting scientific questions at far-infrared wavelengths was demonstrated during SOFIA’s earlier, Northern Hemisphere flights,” said Rolf Guesten of the Max Planck Institute for Radio Astronomy in Bonn, Germany, and leader of the German researchers who developed the spectrometer. “Now, we are turning the instrument to new frontiers such as the Magellanic Clouds, including the Tarantula Nebula — that is the most active star-forming region known in the local group of galaxies.”

Pamela Marcum, the project scientists for SOFIA, said the results anticipated from these southern observations will further scientists’ understanding of star formation, stellar evolution and chemistry in the stellar clouds.

“The deployment exemplifies the synergistic relationship between SOFIA’s international partners, with NASA playing a crucial role in the planning and execution of the science observations,” Marcum said.

SOFIA received major upgrades back in December to its observatory and avionics systems. These upgrades will significantly improve the systems’ efficiency and operability.

Personality, Not Taste Buds, Determine How You Feel About Spicy Foods

Brett Smith for redOrbit.com – Your Universe Online
Anyone who’s ever dared to eat the ‘Suicidal’ chicken wings at the Anchor Bar in Buffalo, NY knows the painful rush that comes with every deliciously fiery bite, and a new study from Penn State researchers suggested that the thrill-seekers among us are the most inclined to like the spicy stuff.
According to the report, which was presented at the 2013 Institute of Food Technologists (IFT) Annual Meeting and Food Expo, people who are more open to unique and intense situations are more likely to enjoy spicy foods.
Conducted by Nadia Byrnes, a doctoral candidate at Pennsylvania State University, the study included over 180 participants between the ages of 18 and 45. They were given the Arnett Inventory of Sensation Seeking (AISS) survey to rate their thoughts on engaging in unique and intense experiences, which Byrnes and her team used to determine participants’ risk preferences.
Statements like, “I can see how it would be interesting to marry someone from a foreign country,” were used to test a participant’s proclivity for unique situations, while a statement like, “When I listen to music, I like it to be loud,” was used to gauge someone’s feelings about intense sensations.
Those participants with the lowest AISS scores were considered to be risk-aversive and not likely to engage in new situations, while those scoring highest were considered to be risk-takers and more open to new experiences.
After taking the AISS test, the volunteers were given 25 micrometers of capsaicin in food, and asked to rate how much they liked what they were eating over the course of the meal, as the burning sensation became more intense. The researchers found that as time passed, participants with lower than average AISS scores quickly began to dislike the food, while those with above average scores liked the food throughout the course of the meal. Participants with average scores also started to dislike the food but not as quickly as those with the lowest scores.
“Theoretically, we know that burn intensity and liking are linear related. The more irritating a compound or food gets, the less people should like it,” Byrnes said. “But that’s not always the case.”
Byrnes’ study builds on her previous study published in April that included 97 volunteers who also took the AISS test. These study participants were then asked to rate the intensity of six different food stimuli, one of which included diluted capsaicin. They then completed questionnaires on how often they ate spicy foods.
According to that study, which was published in the journal Food Quality and Preference, a person’s proclivity for spicy foods depends on “social influences, repeated exposure to capsaicin, physiological differences in chemosensation and personality.”
The study also found that people who liked spicy foods felt the burn just as much as those who said they didn’t.
During the same panel in which Byrnes presented her latest study, Shane McDonald, a chemist at food research and development company Kalsec, discussed the addition of “tingling” spices to foods. Citing a traditional Szechuan cuisine that combines the heat of chili peppers with the tingling sensation of Szechuan peppers, McDonald said tingling sensations could be effectively marketed by American food manufacturers.

New Book Identifies Most Controversial Wikipedia Topics

Enid Burns for redOrbit.com – Your Universe Online

Warning, this article may be heavily edited. The preview of a new book reveals the top ten topics that spark “edit wars” on Wikipedia.

“The most controversial topics on Wikipedia: A multilingual and geographic analysis,” written by Taha Yasseri, Anselm Spoerri, Mark Graham and Janos Kertesz; posted a draft chapter of a book that is to be published next year by Scarecrow Press.

The forthcoming book was written by a team of researchers from Oxford University, Gizmodo reported.

BBC reported that three other institutions were involved in the research and writing of the book. The book looks into the most controversial topics that spur “edit wars” in ten different language versions of Wikipedia. In each language the authors visualize and analyze the similarities and differences that each language produces for hot-button topics.

The book preview teases with the top ten topics in English, German, French, Spanish, Persian, Czech, Hungarian, Arabic, Romanian and Hebrew. The top ten topics for spawning “edit wars” on Wikipedia for the English language are:

1. George W. Bush

2. Anarchism

3. Muhammad

4. LWWEe

5. Global warming

6. Circumcision

7. United States

8. Jesus

9. Race and intelligence

10. Christianity

Topics that remain heated across multiple language versions of Wikipedia include Muhammad, Jesus, September 11 and 9/11 conspiracy theories, Islam, and other forms of religion.

Wikipedia is a citizen record of iconic and notable events, people, figures and topics. Each record on Wikipedia is contributed on a voluntary basis, and is subject to editing by other contributors. Wikipedia estimates that it has 770,000 contributors working on over 22 million articles in 285 languages, according to MIT Technology Review.

The ability to contribute, then edit, raises some controversy and calls into question the integrity of Wikipedia as a source for research.

“So it’s not surprising that disputes arise over the wording of these articles. Indeed, the controversy can sometimes reach war-like proportions with one editor changing the wording and another immediately changing it back again,” said the Technology Review article.

The book poses an interesting look into the Wikipedia workings set against a cultural backdrop.

“The result is a fascinating insight into the way conflicts emerge in different languages and how they are resolved. Yasseri and co also reveal the controversies that are common across language groups and how they vary around the world,” the Technology Review article said.

The book will delve deeper into the editing patterns in each of the Wikipedia language versions, and how they vary.

“Further research is planned to log how controversial topics change over time,” BBC News reported.

“These guys begin by defining what they mean by a controversy. In Wikipedia, the editorial history of every article is easily accessible but the number of changes is by no means a measure of controversy; it may simply indicate a rapidly changing topic,” the Technology Review article said.

“Pages that get updated a lot might just be about a rapidly changing field or topic, they said. By contrast, a topic page in which words and phrases are constantly removed and reinstated gave an insight into the depth of feeling it evoked among contributors,” The BBC News article said.

The public who contribute to and regularly refer to Wikipedia will likely find the academic look the book gives to Wikipedia interesting. The challenge will be that the book will remain in control of the authors, and won’t be subject to editing by the public.

Gold Nanofibers May Help Keep Damaged Heart In Rhythm

April Flowers for redOrbit.com – Your Universe Online

In the wake of a heart attack, the heart’s tissues sustain irreparable damage. Cells in the heart cannot multiply and the heart muscle contains very few stem cells, meaning the tissue is unable to repair itself. The damaged tissue therefore becomes fibrotic and cannot contract correctly.

Looking for new, innovative methods to restore heart function, scientists have been exploring cardiac “patches;” these patches could be transplanted into the body to replace damaged heart tissues.

Dr. Tal Dvir, of Tel Aviv University’s (TAU) Department of Molecular Microbiology and Biotechnology and the Center for Nanoscience and Nanotechnology, has been working with his PhD student Michal Shevach and other colleagues to literally set a gold standard in cardiac tissue engineering. The results of this study were recently published in the Journal of Materials Chemistry B.

One of the largest challenges in developing cardiac patches is ensuring that engineered tissue can mimic the heart’s coordinated electrical system, which controls heartbeat and rhythm. Dr. Dvir’s team integrated cardiac cells with nanofibers made of gold particles to form functional, engineered tissues to overcome this issue, with the goal of optimizing electrical signaling between cells.

Heart cells have proteins on their surface that are responsible for transferring electrical signals. The process of tissue engineering itself, however, leads to the loss of these proteins. Dr. Dvir says that the heart cells will start to produce them again naturally, but they take time to develop. The patient may not have this time. This is where the gold nanofibers come in — they can fill the role of electrical connectors until the cells are able to produce their own connector proteins again.

Cells taken from patients or animals are placed onto a 3D scaffolding made of biomaterials — basically any matter or surface that interacts with biological systems — to create new tissues. This organizes the cells into the proper formation as they grow. The team employed various chemical and physical processes to integrate gold nanoparticles into their scaffolds, which allowed the cells to interact with each other.

A scanning electron microscope and various other measures of electrical activity were used to observe the nanoparticles on the fibers and check conductivity. Significantly stronger contractions were observed with cells placed on gold-embedded scaffolding when compared to those without the gold. More importantly, the cells demonstrated effective electrical signaling by contracting in unison.

New treatment options are sorely needed for heart attack victims because 50 percent die within five years of their initial attack. Functioning, transplantable tissue could save lives, and improve the patient’s quality of life.

Dr. Dvir and the team at his Tissue Engineering and Regenerative Medicine Laboratory plan to continue their research by evaluating the potential for the gold infused cardiac patches to improve function after heart attack through pre-clinical tests in the lab and, eventually, clinical trials with patients. Dr. Dvir says that the ideal method would be to use a patient’s own cells when building the new tissue, therefore avoiding the risk of rejection.

Butterflies Could Inspire New Hue-Changing Materials

April Flowers for redOrbit.com – Your Universe Online

Butterflies have beautiful wings full of colorful patterns that do remarkable things with light. A new study from a Hong Kong Baptist University team of physicists has uncovered how subtle differences in tiny crystals of butterfly wings create stunningly varied patterns of color, even among closely related species. If the team can figure out how to replicate the wings’ light-manipulating properties, the discovery could lead to new coatings for manufactured materials that could change color by design.

“It was very exciting to see how nature can create a nanostructure that’s not easy to replicate by humans,” says Kok Wai Cheah, a physicist at Hong Kong Baptist University. Cheah and his team are the first to investigate the color-creating properties in multiple butterfly species within a single genus.

The research team studied three tropical butterfly species that display iridescence – a property of materials that change color depending on the viewing angle. All three, however, displayed different colors. When seen from above, Papilio ulysses, the Ulysses butterfly or blue mountain swallowtail, appears bluish green, while its cousin Papilio peranthus, by contrast, looks yellowish green, and a third relative, Papilio blumei, the green swallowtail, is more of a deep green. All three species shift toward a deep blue color when viewed from a sharp angle.

To understand the physics behind the wings’ structural colorations, the team looked at a cross-section of each species’ wing under a scanning electron microscope. The wings contain specialized architectures, with solid flat layers known as cuticles alternating with thin “air” layers known as laminae. The laminae aren’t entirely air, however. They also contain pillars of cuticle material, giving the wing a repeating crystal-like structure, which is similar to a Bragg reflector – essentially a multi-layered mirror that reflects only certain wavelengths, or colors, of light.

The light spectrum reflected from the wing at different angles was then measured using a technique called angle-resolved reflection spectroscopy. The researchers found that the varying colors between the three species’ wings are because of slight differences in crystal parameters. For example, P. ulysses has seven cuticle layers, while P. peranthus has eight. There is a variation between thicknesses of cuticles and air layers between the species as well. Even though these differences are slight, Cheah notes, they have a major effect on the butterflies’ appearance. “It all comes from the fact the wing structure has subtle differences between these three types of butterfly,” he says.

The lessons learned from butterfly wings could lead to designer materials, Cheah thinks. These materials wouldn’t need to be painted or dyed one specific color. An article of clothing could reflect a subdued color during the workday, and then display a more ostentatious one at night. “You would just tune your structure to produce the color you want,” says Cheah.

The team is planning further research to investigate color-generating mechanisms in other insect body structures, such as the metallic effect produced by iridescent beetle shells.

The findings of this study were reported in the open-access journal, Optical Materials Express.

Making Batteries From Bacteria

Lee Rannals for redOrbit.com – Your Universe Online

Students at Germany’s University of Bielefeld are using the bacteria Escherichia coli to help construct a bio-battery.

Ten students have been spending their free time in the laboratory in order to construct the bio-battery as their entry into this year’s international Genetically Engineered Machine competition (iGEM) at MIT. The team is using the bacteria to convert glucose into energy.

“There is an ever-increasing demand for sources of alternative energy. The conservation of fossil fuels and the phasing out of nuclear energy in Germany have sped this process up,” said Thorben Meyer, a student who participated in the project. “It is not only large-scale electricity production which pollutes the environment, but also household batteries, which contain many harmful substances. Heavy metals and dangerous inorganic and organic electrolytes can be released into the environment by improper handling of batteries.”

Batteries like the one the Beilefeld students are developing work similarly to conventional batteries. These environmentally friendly microbial fuel cells (MFC) consists of two separate units, the anode and the cathode components, just like traditional batteries. However, these bio-batteries contain bacteria in the anode area instead of electrolytes. These bacteria break down substrates via their natural metabolic process.

During this process, electrons are produced that are delivered in an external loop to the cathode. The external circuit is then the one with the battery-powered application.

Bio-batteries could potentially be used in regions where there is a shortage of electricity, such as in developing countries or disaster areas. The batteries are not dependent on the weather either, making them advantageous energy sources compared to other forms of green energy like solar and wind power.

The students investigating the bacteria battery said it is possible to optimize the organism E. coli with a view to producing electricity more efficiently. The team has already been able to isolate various genes within the organism that serve to carry the electrons. They have also started to construct a suitable apparatus for the production of electricity.

iGEM participants are expected to find sponsors to cover competition fees, travel costs and accommodation. The competition has been hosted annually at MIT since 2004.

“Internationally, iGEM is the most important student competition in synthetic biology. Its form makes it unique in the world,” said Dr. Joern Kalinowski, who is supporting the Beilefeld students. “Synthetic biology is the latest development in the field of modern biology, and participation in the competition opens the students up to new perspectives. They also have the opportunity to prove themselves against young scientists from around the world.”

Last year a group from the University of Alberta won the iGEM competition after discovering a way to turn waste paper into valuable chemicals. The students developed plans for a startup biotech company called Upcycled Aromatics to turn paper that cannot be recycled into high-value specialty chemicals, including one key ingredient for the flu vaccine Tamiflu.

Mapping Nepalese Attitudes Towards Endangered Tigers

April Flowers for redOrbit.com – Your Universe Online

A new study from Michigan State University reveals it is much easier to feel positive about the endangered Bengal tiger in your backyard if you live on the good side of town. The study, published in AMBIO, examined what factors influenced people’s attitudes towards the tigers that share their neighborhood in Nepal’s Chitwan National Park, which is home to some 125 adult tigers. The decision to map people’s attitudes represents a novel approach from the research team.

“Harmonizing human-wildlife relationships is key to sustainably conserving wildlife such as the endangered tigers,” said Jianguo “Jack” Liu, MSU’s Rachel Carson Chair in Sustainability, director of the Center for Systems Integration and Sustainability (CSIS). “People’s attitudes towards tigers shape the fate of tigers.”

A map of attitudes toward tigers – a clear plotting of the haves, the have-nots, and how social status shapes different views of wildlife conservation – was created by Neil Carter, PhD student at CSIS who has spent years studying how people and tigers co-exist in Nepal.

The researchers surveyed 500 Chitwan residents to find that it’s not so much the contact a person has with a tiger – a scare, an attack, losing livestock. Instead, neighborly feelings towards carnivores, they found, is something of a luxury and depends on the person’s social and economic status.

The study area included 100-square miles of forest and settlements on the west side of Chitwan. The people in this area who report supporting the protection of tigers live in the more prosperous east side. The eastern neighborhoods are comparatively urban, with residents who are more economically secure, have more clout with the local government and have more resources beyond just those the forest provides.

When surveyed by the researchers, the residents of the more prosperous east side were more likely to report positive attitudes toward tigers. The team found this was because these residents profited directly from the tigers’ presence – they work as guides or porters for tourists, for example. They are also more educated, feel that you can control your surroundings and influence the world around you, then you tend to be more positive about what’s in the forest.

Residents on the more rural and isolated west side, on the other hand, depend more directly on the forest for sustenance. Carter suggests the daily dependence on the forest not only makes them more vulnerable to tiger attacks, but also makes conservation regulations more burdensome and fuels tiger intolerance. The west side residents also tended to feel less empowered, with less input into regulations and less recourse when things aren’t going well.

“This is important to know from a wildlife conservation standpoint,” Carter said. “There’s reason to expect people on the west side to be less compliant with conservation policies, for example, by killing tigers in retaliation to attacks or to harbor poachers.”

The lessons learned in Nepal shed light on what makes or breaks conservation efforts around the globe in areas where people live next door to wolves, coyote, bears – animals that inspire fascination and fear. Human buy-in is essential for conservation efforts. The team hopes their work will allow conservation managers to create maps of attitudes toward many other wildlife species.

“It surprised me how powerful the effect of the social, cultural and economic factors had on their attitudes,” Carter said. “This is showing us that conservation is not just the wildlife issues. It’s very much about managing people and their needs, and knowing where to focus attention.”

Line Island Expedition Will Shed Light On Microbial Dynamics Of Coral Reef Robustness And Decline

April Flowers for redOrbit.com – Your Universe Online
Climate change, unsustainable fishing, and pollution are serious threats facing coral reefs. A multidisciplinary series of studies is being conducted to understand the underlying processes. The researchers are investigating variability in coral reef community structure and microbial dynamics across gradients of natural and anthropogenic stress.
The results of the “Line Islands Collection – Microbial dynamics of coral reef robustness and decline” – named after their upcoming expedition to the Line Islands – have been published in the new PeerJ open access journal.
The expedition to the Line Islands – located in the central Pacific Ocean with one of the most pristine coral reef systems remaining on Earth – is part of an effort to better understand the effects of anthropogenic influences on these fascinating ecosystems, and specifically how microbial communities affect coral reef robustness and decline. The expedition will be launched in the fall of 2013. In preparation for the expedition, the team is launching a Collection of related articles in PeerJ. The Collection – launched on July 16 with four initial articles – will continue to grow as the work of the research collaboration builds up.
The focus of the expedition to the Line Islands will be to shed light on the intricate interactions between microbes, coral, algae and fish. To accomplish this task, the research team has a wide range of expertise in many different scientific disciplines.
The interactions between microbes and macroorganisms in coral reefs, specifically how these systems respond to perturbation, are being investigated by the Laboratory of Forest Rohwer at San Diego State University.
A team from Scripps, led by Jennifer E. Smith, will investigate how local human impacts – such as fishing, pollution and species invasion-and global human impacts, like warming and acidification – affect competitive dynamics among benthic taxa and alter community structure.
A second Scripps team, led by Stuart Sandin, has interests that are centered on predator/prey dynamics and how those dynamics shape the coral reef community.
Together, these three groups have investigated, and will continue to investigate, the biogeochemical processes which shape coral reef ecosystems, spanning spatial scales from microns to thousands of kilometers.
By creating a comprehensive Collection, the research teams hope to demonstrate some of the implications that result from considering coral reef microbiology on a new scale – something which may help others to see these findings in their broader context.

Digital Tools Having Both Positive, Negative Effects On Student Writing

Lee Rannals for redOrbit.com – Your Universe Online

The boom of technology over the past two decades has started phasing out cursive handwriting in classrooms. However, a new survey by Pew Research Center finds teachers believe the Internet and social media actually encourage students to write better.

According to the survey, 96 percent of advanced placement (AP) and National Writing Project (NWP) teachers say digital technologies allow students to share their work with a wider and more varied audience. The teachers said digital tools like the Internet, social media and cell phones “encourage student creativity and personal expression.”

The teachers say students’ exposure to a broader audience for their work and more feedback from peers encourages greater student investment in what they write and in the writing process as a whole.

Teachers in the survey did share some worries about how digital tools are having some undesirable effects on student writing. They said there is an increasingly ambiguous line being drawn between “formal” and “informal” writing and the tendency for students to use informal language and style in formal writing assignments.

Sixty-eight percent of the teachers surveyed said digital tools make students more likely to take shortcuts and not put effort into their writing, while 46 percent said these tools make students more likely to “write too fast and be careless.”

Half of the teachers surveyed said digital tools have made teaching writing easier, compared to just 18 percent who said it has made it more difficult.

Overall, teachers say they have given their students’ writing skills modest marks, and see areas that need attention. AP and NWP teachers tended to rate their students “good” or “fair” as opposed to “excellent” or “very good.” Most of the teachers said their students were best at effectively organizing and structuring writing assignments. Students have also shown to have a better ability at understanding and considering multiple viewpoints on a particular topic or issue.

“Alongside the use of digital tools to promote better writing, almost all AP and NWP teachers surveyed say they encourage their students to do at least some writing by hand,” Pew said. “Their reasons are varied, but many teachers noted that because students are required to write by hand on standardized tests, it is a critical skill for them to have.”

Weill Cornell Presents Updated Results From Phase 3 Trial Of IVIG For Alzheimer’s Disease

Additional data from GAP study presented by Dr. Norman Relkin at Alzheimer’s Association International Conference

Weill Cornell Medical College neurologist Dr. Norman Relkin reported new findings today from the Phase 3 clinical trial of IVIG (intravenous immunoglobulin) in mild to moderate Alzheimer’s disease at the Alzheimer’s Association International Conference (AAIC) in Boston, Mass. While the primary study outcomes were negative, observations from the subgroup analyses include whether there may be a dose-dependent reduction of beta amyloid in the blood and brain of IVIG-treated Alzheimer’s patients who have the ApoE4 genotype.

IVIG is a mixture of antibodies derived from the blood of healthy donors. Given its ability to control infection and inflammation, IVIG has been used to treat disease for more than 30 years. It has been approved for use in treating several disorders, ranging from pediatric immune disorders to a blood cancer and Kawasaki disease, but is not approved for Alzheimer’s disease.

The Gammaglobulin Alzheimer’s Partnership (GAP) Study was a Phase 3, randomized, double-blind, placebo-controlled clinical trial in 390 people with mild to moderate Alzheimer’s disease, conducted at 45 centers in the U.S. and Canada. Two different doses of IVIG were tested versus placebo as add-ons to approved Alzheimer’s medications. The drug was administered every two weeks for 18 months. Primary study endpoints were changes on two well-established tests of cognition and daily functioning — the ADAS-Cog and ADCS-ADL.

In a topline announcement in May, the GAP researchers reported negative results on the GAP study’s primary outcomes — the ADAS-Cog and ADCS-ADL. At the same time, preliminary observations were reported on favorable changes on another cognitive test, the Modified Minimental State Examination (3MS) in two subgroups: people with Alzheimer’s who carried the APOE-e4 Alzheimer’s risk gene, and those who were moderately impaired. The study was not powered to show statistical significance in these pre-planned subgroup analyses.

Today at the AAIC meeting, Dr. Relkin reported for the first time on additional cognitive and biomarker tests that shed further light on the study’s outcomes. The researchers found that study participants in the APOE-e4 carrier subgroup receiving IVIG 400mg/kg/2wk (n=87) had numerically superior results at 18 months relative to placebo on the Modified Mini-Mental State (3MS) Examination (n=66) and the Trails B test (n=77), two out of several measures of thinking ability made in the study. “Though 3MS and Trails B were not the primary outcome measures in the study, they are well-established cognitive measures.” Dr. Relkin says.

Biomarker analyses demonstrated that antibodies from the treatment reached the central nervous system. Among the findings that Dr. Relkin reported:

-A statistically significant, dose dependent reduction in plasma beta-amyloid 42 levels (but not beta-amyloid 40) was observed in IVIG treated patients relative to placebo.
-Statistically significant, dose dependent increases in anti-oligomer and anti-fibril antibodies in the CSF or plasma occurred in IVIG-treated patients relative to placebo.
-A reduction in brain fibrillar amyloid (as measured by PET scan using florbetapir) was seen in patients who received IVIG at the 400mg/kg/2wk dose, particularly those who were APOE-e4 carriers.
-No effect in tau and phosphorylated tau levels in spinal fluid.

“It is important to say that the GAP study results do not provide grounds for prescribing IVIG in Alzheimer’s disease, even with this positive signal in the APOE-e4 carriers,” Dr. Relkin says. “Further confirmatory studies and regulatory approval would be needed before clinical use could be recommended.”

“The primary clinical outcomes are unequivocally negative, but there are intriguing signals in the clinical and biological markers,” he adds “With the understanding that we cannot draw conclusions about IVIG’s effectiveness in these subgroups from these results alone, the effects of IVIG on beta-amyloid and antibody levels in the blood and brain are noteworthy. These results support that IVIG can target beta amyloid and that the antibodies it contains can reach the brains of people with Alzheimer’s when administered through the bloodstream.”

Despite the negative results of the Phase 3 IVIG trial, and because of the successes of IVIG in animal models of Alzheimer’s and early stage trials in people, researchers continue to pursue how IVIG may work in the brain to inform ongoing Alzheimer’s therapy research.

“The favorable data in subjects who carry the APOE-e4 gene also underscores the need for further research and emphasis on a precision medicine approach to Alzheimer’s,” Dr. Relkin says. “The APOE-e4 carrier group is easily identified by genetic testing. It may be important to more specifically target our next generation of Alzheimer’s therapies with an eye towards treating identifiable subgroups of patients such as APOE-e4 carriers.”

Earlier Phase Studies at Weill Cornell Showed Promise of IVIG

Dr. Relkin is associate professor of clinical neurology at Weill Cornell Medical College and study leader of the Gammaglobulin Alzheimer’s Partnership (GAP) trial, conducted by Baxter International and the Alzheimer’s Disease Cooperative Study (ADCS), a clinical trial consortium supported by the United States National Institute on Aging in the National Institutes of Health.

Dr. Relkin, who is also director of the Memory Disorders Program at NewYork-Presbyterian Hospital/Weill Cornell Medical Center and a researcher in Weill Cornell’s Feil Family Brain and Mind Research Institute, became interested in IVIG when he and Weill Cornell colleagues Dr. Mark Weksler and Dr. Paul Szabo found evidence in 2003 of decreased levels of free antibodies against beta amyloid in the blood of patients with Alzheimer’s disease. Following a report by German investigator Dr. Richard Dodel that IVIG contained increased levels of anti-amyloid antibodies, they began testing IVIG as a potential anti-amyloid immunotherapy for Alzheimer’s disease.

For example, Dr. Relkin reported in 2006 that a pilot study found IVIG stabilized or improved cognitive function in Alzheimer’s patients when administered over a period of a year or more. When the treatment stopped, cognitive abilities began to decline, and then stabilized once more when the treatment was offered again.

A 2007 laboratory analysis by Dr. Relkin and his colleagues demonstrated that antibodies in IVIG could not only recognize and scoop up toxic beta amyloid proteins, but also other proteins that accumulate in a wide variety of neurodegenerative diseases.

Phase2 GAP results demonstrated that patients who responded best to IVIG did not measurably decline in cognitive abilities over 18 months and had an average rate of brain shrinkage similar to elderly individuals who did not have the disease. Dr. Relkin presented these findings in April 2010 at the annual meeting of the American Academy of Neurology.

Dr. Relkin proposed the GAP trial after the earliest phase studies he carried out showed the promise of IVIG in slowing dementia-related decline. The Phase 1 and Phase 2 trials he performed involved relatively small numbers of patients, however, making the generalizability of the findings uncertain. He proposed the GAP study as a means of assessing IVIG’s safety and effectiveness in a larger number of Alzheimer’s patients.

“The Phase 3 GAP study was conducted at a very high standard, setting goals that have not yet been reached by any medication for Alzheimer’s disease that is approved or under investigation,” Dr. Relkin says. “What we stand to learn from this research cannot be overstated. The data reinforces some of the findings from the earlier phases of the GAP study, and we need now to delve deeper into the data to help move forward toward improving the treatment of Alzheimer’s disease.”

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Music Soothes And Eases Pain For Pediatric ER Patients

redOrbit Staff & Wire Reports – Your Universe Online

A team of US and Canadian researchers have discovered new evidence suggesting that music can help reduce feelings of pain and distress amongst pediatric ER patients.

As part of the study, which was published in Monday’s edition of the journal JAMA Pediatrics, lead investigator Lisa Hartling of the University of Alberta and her colleagues conducted a clinical research trial of 42 children between the ages of three and 11.

All of the children were treated at the Stollery Children’s Hospital in Edmonton, and each of them required IVs, the researchers said. Some of those youngsters listened to music while getting their IVs, while others did not.

Hartling and her colleagues measured each patient’s distress levels, perceived pain levels, and heart rates, as well as the satisfaction rates of both their parents and the health-care providers treating the children. The trial was conducted from January 2009 through March 2010.

“We did find a difference in the children’s reported pain – the children in the music group had less pain immediately after the procedure,” Hartling explained in a statement. “The finding is clinically important, and it’s a simple intervention that can make a big difference. Playing music for kids during painful medical procedures would be an inexpensive and easy-to-use intervention in clinical settings.”

According to the study authors, the children who listened to music reported experiencing significantly less pain, and some of them also experienced less distress. In addition, the parents of those children tended to be more satisfied with the level of care that their sons and daughters received.

More than three-fourths (76 percent) of the health care providers who worked with the music-listening group said that the IVs were very easy to administer, compared to just 38 percent for those working with the other youngsters. The researchers also reported higher levels of distress amongst children who were born prematurely.

Hartling said that she and her colleagues hope to further their work in the area, focusing on whether or not music or other types of distractions can be used to provide relief for pediatric patients undergoing other painful medical procedures. The pain and distress caused by those procedures, the authors said, can have “long-lasting negative effects” on the youngsters who have to undergo them.

“There is growing scientific evidence showing that the brain responds to different types of music in very specific ways,” said Hartling, who is an assistant professor in the university’s Faculty of Medicine and Dentistry. “So additional research into how and why music may be a better distraction from pain could help advance this field.”

Adult Human Cells Used To Create Long-Lived Blood Vessels

redOrbit Staff & Wire Reports – Your Universe Online

Massachusetts General Hospital (MGH) researchers have managed to create long-lasting blood vessels from reprogrammed human induced pluripotent stem cells (iPSCs), This groundbreaking research is published in the latest issue of the Proceedings of the National Academy of Sciences (PNAS) Early Edition.

Using vascular precursor cells derived from iPSCs, reprogrammed adult cells that have several of the same characteristics of embryonic stem cells, the scientists were able to create functional blood vessels in an animal model that lasted up to nine months. In their study, the authors describe how they used cells from both healthy adults and those with type 1 diabetes to generate blood vessels under the skin or on the brain’s outer surface in mice.

“The discovery of ways to bring mature cells back to a ‘stem-like’ state that can differentiate into many different types of tissue has brought enormous potential to the field of cell-based regenerative medicine, but the challenge of deriving functional cells from these iPSCs still remains,” said co-author Rakesh Jain, director of the MGH Steele Laboratory for Tumor Biology.

“Our team has developed an efficient method to generate vascular precursor cells from human iPSCs and used them to create networks of engineered blood vessels in living mice,” he added.

Their work could lead to medical advances such as the treatment of cardiovascular disease and other ailments through the regeneration or repair of blood vessels, and could eliminate one of the obstacles preventing tissue engineering from creating usable organs.

Researchers have, in the past, been able to use iPSCs to build endothelial cells that line vessels and connective tissue cells that provide structural support. However, those cells were unable to form long-lasting blood vessels once they were introduced into animal models.

According to co-senior author Dai Fukumura, also of the Steele Lab, the largest obstacle the researchers faced was, “establishing a reliable protocol to generate endothelial cell lines that produced great quantities of precursor cells that could generate strong, durable blood vessels.”

Jain, Fukumura and their colleagues took a method originally used to derive endothelial cells from human embryonic stem cells (hESCs) and adapted it. The method originally used a single protein marker to identify vascular progenitors, but the iPSC-derived cells used that protein marker as well as two others with vascular potential.

Next, they expanded that population using a culture system that members of the team developed to differentiate endothelial cells from hESCs, and found only iPSC-derived cells expressing all three markers were capable of generating endothelial cells with the full potential of forming functional blood vessels.

“To test the capacity of those cells to generate functional blood vessels, they implanted onto the surface of the brains of mice a combination of the iPSC-derived endothelial precursor cells expressing the three markers with the mesenchymal precursors that generate essential structural cells,” the hospital explained in a statement. “Within two weeks, the implanted cells had formed networks of blood-perfused vessels that appeared to function as well as adjacent natural vessels and continued to function for as long as 280 days in the living animals.

“While implantation of the combined precursor populations under the skin of the animals also generated functional blood vessels, it required implantation of five times more cells, and the vessels were short-lived, an observation consistent with the team’s previous studies of vessel generation in these two locations,” they added.

Since type 1 diabetes can damage a person’s blood vessels, and those patients could benefit from the ability to manufacture blood vessels, the study authors wanted to figure out if iPSCs derived from their cells could help generate functional blood vessels.

“As with cells from healthy individuals, precursors derived from T1D-iPSCs were able to generate functional, long-lasting blood vessels,” the hospital said. “However, the researchers note, different lines of the T1D-iPSCs — including different lines derived from the same patient — showed differences in cell-generating potential, indicating the need to better understand the underlying mechanisms.”

“The potential applications of iPSC-generated blood vessels are broad — from repairing damaged vessels supplying the heart or brain to preventing the need to amputate limbs because of the vascular complication of diabetes,†noted co-lead author Rekha Samuel of the Christian Medical College in India.

However, she cautions scientists must first overcome challenges such as, “the variability of iPSC lines and the long-term safety issues involved in the use of these cells,” as well as develop, “better ways of engineering the specific type of endothelial cell needed for specific organs and functions.”

Sexuality And Attractiveness Key To Female Bonobo Dominance

April Flowers for redOrbit.com – Your Universe Online

Among mammalian species, female social dominance is rare. However, one of our closest living relatives, bonobos, are known for the relatively high statuses females hold in social groups. This puzzles researchers as the males are often bigger and stronger than the females. A new study from the Max Planck Institute for Evolutionary Anthropology has analyzed the dominance relations between male and female wild bonobos, taking particular interest in the high social status of some females.

It is not female alliances that help females win conflicts with males, the study reveals, nor does the context of the conflict seem to be relevant for the outcome either. Instead, the researchers found the determining factor was sexual attractiveness. If the females in the conflicts with males displayed sexually attractive attributes, including sexual swellings, then they tended to win the conflict more easily. The males in these conflicts behave in a less aggressive way as well.

Intersexual dominance relations in bonobo populations have never been thoroughly studied in the wild. However, several theories exist for how females reach their elevated status. One theory proposes bonobo female dominance is facilitated by females forming coalitions which suppress male aggression. Another theory suggests an evolutionary scenario in which females prefer non-aggressive males which renders male aggressiveness a non-adaptive trait.

Recently, a study from the Lui Kotale bonobo project from the Max Planck Institute for Evolutionary Anthropology reported on the outcomes of intersexual conflicts in a bonobo community near the Salonga National Park in the Democratic Republic of the Congo. The analysis of male/female conflicts revealed a sex-independent dominance hierarchy with several females occupying top ranks.

The team also discovered only two factors have a significant influence on the outcome of intersexual conflicts. The first is female motivation to help their offspring, and the second is attractiveness. They found when females defend their offspring against male aggression, often alone but sometimes in groups, males defer to females. They found it even more interesting females are more likely to win conflicts against males during times when they exhibit sexual swellings indicating elevated fecundity.

Martin Surbeck of the Max Planck Institute for Evolutionary Anthropology says, “In those situations, males also aggress females less often, which is different from chimpanzees, our other closest living relatives.” The study findings suggest in bonobos both female sexuality and male mating strategies are involved in the shifting dominance relationships between the sexes.

Families Who Connect Through Social Media Feel Closer

redOrbit Staff & Wire Reports – Your Universe Online

Teenagers who are connected to their parents on social media feel closer to them in real life, according to new research from Brigham Young University.

The study of nearly 500 families also found teens that interact with their parents on social media such as Facebook, Twitter and Instagram are more likely to be generous, kind and helpful to others.

Lead study author Sarah Coyne said one of the reasons social media helps families feel more connected is because it provides people with opportunities to give positive feedback and show affection.

“Social networks give an intimate look at your teenager’s life. It lets parents know what their kids are going through, what their friends think is cool or fun, and helps them feel more connected to their child. It gives a nice little window into what is going on,” she said.

Coyne said half of the teens in the study reported being on social networking sites with their parents, while 16 percent interacted with parents every day through social media.

More frequent interactions were linked to more family closeness, she added.

“The more frequently parents used social media to interact with teens, the stronger the connection.”

However, parents need to be mindful not to take things too far with social media, she said.

“Parents need to be smart about how they use it. I think it is a really great tool to connect with your kids. But just like everything else, it’s got to be used in moderation. You don’t want to be the parent who posts embarrassing pictures of your kid all the time or makes snarky comments. You have to keep it at the level that’s appropriate and respectful of what the teen wants as well.”

Coyne acknowledged some of the improved closeness between teens and parents who interact through social media is a “chicken and egg” phenomenon.

“Parents who are more connected to their teens in general want to keep that connection elsewhere,” she said.

“As we have experiences in new media, it strengthens bonds that are already there. It’s kind of a rich get richer type of thing and cementing what’s already there.

“You don’t want these results to get overblown to say, ‘If you friend your kid on Facebook, you’re suddenly going to have a great relationship.’ It’s just one tool in an arsenal that parents have to connect with their teens. This is what teens are doing – they are on social media already, so it’s a nice tool to use,” she said.

The study also revealed overall social networking use, independent of parental use, was associated with certain negative outcomes for teenagers, such as higher rates of aggressiveness and internalizing behavior.

“That was a little surprising to me,” Coyne said.

“We tend to think of social networking as relatively harmless, and for the most part it really is. But kids who are using it a ton – we had some kids in the study who were using it more than 8 hours a day – some of them show problems in terms of aggression and depression.”

Coyne advised parents to be media savvy and stay up to date on social networking trends.

“If you really want to stay involved with your kid, you can’t be afraid to learn new technology, to learn new web sites and to know where your teen is.”

The study was published online July 11 in the journal Cyberpsychology, Behavior, and Social Networking.

French, US Studies Shed Light On Alzheimer’s Disease And Dementia

Brett Smith for redOrbit.com- -Your Universe Online

Alzheimer’s disease affects millions of Americans and two new studies have uncovered interesting information about the disease.

In one study of almost 500,000 French men and women, people who delayed retirement were found to have less of a risk of developing Alzheimer’s or other types of dementia. In the other study of 3.5 million US military veterans, those diagnosed with cancer were less likely to have Alzheimer’s and those who received chemotherapy were even less likely.

The French study is said to be the largest to look at the connection between delayed retirement and dementia. It appears to be consistent with previous findings that encourage older people to stay mentally stimulated and socially active.

“For each additional year of work, the risk of getting dementia is reduced by 3.2 percent,” study author Carole Dufouil of INSERM told CBS News.

Alzheimer’s research was emphasized by former French president Nicolas Sarkozy, and the country’s integrated medical system made for a more robust study, according to reports. The researchers used those comprehensive medical records to look at health outcomes for around 429,000 workers.

The French team found that almost three percent of those in the study had developed dementia, but the risk of this was lower for each year of age at retirement. To eliminate the possibility that the retirement was caused by dementia, the French team ruled out anyone who was diagnosed with dementia within five or ten years of retirement.

“The trend is exactly the same,” Dufouil said.

The US military study echoes the findings of a similar study on older Italians released last week – those diagnosed with cancer are less likely to also be diagnosed with Alzheimer’s.

“With these large-cohort studies and others, we are beginning to see the outlines of a broad picture of Alzheimer’s disease risk and prevention factors,” said Maria Carrillo, vice president of medical and scientific relations at the Alzheimer’s Association.

“However, we need to know even more about what specific factors actually raise and lower risk for cognitive decline and Alzheimer’s,” Carrillo said. “To do that, we need longer-term studies in larger and more diverse populations, and more research funding is required to make that happen. Alzheimer’s research would benefit from its own version of the Framingham Study, which has taught us so very much about preventable risk factors for heart disease and stroke.”

Providing a wider scope than the Italian study which did not look at individual cancers, the US military study found that reduced risk was greatest among survivors of liver cancer (51 percent lower risk), cancer of the pancreas (44 percent), lung cancer (25 percent) and leukemia (23 percent).

The study also found that treatment with chemotherapy, but not radiation, reduced Alzheimer’s risk by 20 to 45 percent among veterans with a cancer history.

“The potential protective effect of chemotherapy is supported by recent experimental studies,” said study co-author Dr. Laura Frain, a geriatrician at VA Boston Healthcare System. “The results of this study are interesting because they could help focus future research onto the specific pathways and treatment agents involved in the individual cancers that are associated with a reduced risk of Alzheimer’s. This could potentially open new therapeutic strategies for Alzheimer’s prevention and treatment.”

Phytoplankton Join ‘Social Mixers’ In Ocean Turbulence

[Watch the video: Phytoplankton Social Mixers]
Lee Rannals for redOrbit.com – Your Universe Online
The motility of phytoplankton allows the tiny ocean plants to determine their fate in ocean turbulence, according to scientists at MIT and Oxford University.
Researchers wrote in the journal Nature Communications that the individual vortices that make up ocean turbulence are like social mixers for phytoplankton. This social mixer brings similar cells into close proximity, helping to enhance sexual reproduction and other ecologically desirable activities.
Scientists previously believed that phytoplankton were passive drifters, unable to defy even the weakest currents orto  travel of their own accord. However, researchers have now shown that many species can actually swim, and do so to optimize light exposure and to avoid predators. The latest study found that when these micro-plants are caught in an ocean vortex, they form highly concentrated patches at the center of the swirl. This process continues to repeat itself, allowing phytoplankton to move from social mixer to social mixer.
“Based on our intuition of turbulence and turbulent mixing, we expected homogeneity to reign,” says Roman Stocker, an associate professor of civil and environmental engineering at MIT who led the study. “Instead, the phytoplankton surprised us by forming highly concentrated clusters of cells – it’s turbulent un-mixing. For the phytoplankton, this is a vehicle to effectively find cells of the same species without any sensory information on each other’s location or the need to invest in costly means of chemical communication.”
These highly concentrated patches can also have a downside since phytoplankton form the base of the ocean food chain and proximity makes them easy prey.
“While patchiness increases the chance of a fatal encounter with a predator, it also increases the chance of finding other phytoplankton cells, which is needed to form resilient cysts that can survive harsh winter conditions,” says William Durham, the paper’s first author and a lecturer at Oxford University who began working on this study as a doctoral student at MIT.
“This mechanism suggests phytoplankton might tune their motility to have the best of both worlds, minimizing patchiness when there are a lot of predators around while maximizing patchiness when the time is ripe for cyst formation.”
The researchers team first performed experiments using phytoplankton in the lab, then extended their observations to a turbulent ocean using high-resolution simulations. They used a transparent box shaped like the letter H with seawater flowing upward through the vertical bars to create two inner-directed vortices within the horizontal bar. When the team added a red-tide-forming species of phytoplankton known as Heterosigma akashiwo to the mix, they formed dense patches at the centers of the swirls.
The team found that patchiness increased more than tenfold when phyotoplankton swam. This research led to the conclusion that the microorganisms might have evolved to develop the ability to actively adjust their swimming speeds to modulate interactions with others of the same species.
“Life is turbulent in the vast expanses of the ocean – and it’s fascinating to learn how some of the most important organisms on our planet fare and behave in their daily turbulent lives,” Stocker concluded.

Sculpting Flow

TACC supercomputers help microfluidics researchers make waves at the microscopic level

Have you ever noticed the way water flows around boulders in a fast-moving river, creating areas of stillness and intense motion? What if those forces of fluid flow could be controlled at the smallest levels?

In May 2013, researchers from UCLA, Iowa State and Princeton reported results in Nature Communications about a new way of sculpting tailor-made fluid flows by placing tiny pillars in microfluidic channels. By altering the speed of the fluid, and stacking many pillars, with different widths, placements and orientations, in the fluid’s path, they showed that it is possible to create an impressive array of controlled flows.

Why does this matter?

Because such a method will allow clinicians to separate white blood cells from other cells in a blood sample, increase mixing in industrial applications, and more quickly perform lab-on-a-chip-type operations, like DNA sequencing and chemical detection. Each of these could form the foundation for a multi-million dollar industry. Together, they could revolutionize microfluidics.

“Most microfluidic flow is at a very low speed,” said Baskar Ganapathysubramaniam, assistant professor of mechanical engineering at Iowa State and one of the lead researchers. “At that speed, the flow hugs the cylinder and there’s fore-aft symmetry. Whatever’s happening upstream is exactly mirrored downstream. But if you increase the speed — or more technically, the Reynolds number — slightly, you can break this symmetry and get wakes, vortices, and non-trivial deformations.” All of which create distinct flows.

Hashing out the idea with Dino Di Carlo, associate professor of bioengineering at UCLA, the two researchers asked themselves if they could control the flow of fluids in microfluidic channels by placing pillars in specific locations in the path. Using both experimental methods and numerical simulations, they explored the possibilities offered by this approach and found that they could indeed create a range of predictable flows.

“Each pillar has a unique deformation signature to it,” Ganapathysubramaniam said. “By stacking these pillars together, we can create an astounding variety of deformations, and these can be tuned for specific purposes.”

“Engineering tools like this allow a scientists to easily develop and manipulate a flow to a shape of their interest,” Di Carlo said. “There hasn’t been that platform available in the fluids community.”

The equations used to determine the fluid flows are fairly straightforward, but the number of configurations needed to solve the problem required them to use the Ranger supercomputer at the Texas Advanced Computing Center (TACC). Ranger, funded by the National Science Foundation (NSF), served the national open science community for five years and was replaced by Stampede (the sixth most powerful supercomputer in the world) in January 2013.

Using several thousand processors concurrently, the researchers ran more than a 1,000 different problems, each representing a combination of different speeds, thicknesses, heights or offsets.

“Each of these gives us one transformation and together, they form what we call a library of transformations,” DiCarlo described.

With this method, Ganapathysubramaniam says it’s possible to create a sequence of pillars that would push white cells to the boundaries of a channel to separate them, and then return them to the center to be recaptured. He is also excited to study the potential of pillars to enhance mixing, which would be useful for removing heat from microprocessor fabrication as well as nano- and micro-scale controlled manufacturing.

Eventually, DiCarlo and Ganapathysubramanian want to crowd-source the identification of critical flow transportations that will have implications to industry.

“Once we have the library, we envision creating a video game where we ask the player to design a specific kind of flow transformation,” Ganapathysubramaniam explained. “They pick different pillars, stack them together, and see if they can get that configuration.”

It’s this kind of out-of-the-box thinking that characterizes the Iowa State scientist’s research. Recently, partnering with Manish Parashar, the director of the Rutgers Discovery Informatics Institute (RDI2) at Rutgers University, and with Rutgers research professor Jaroslaw Zola, Ganapathysubramaniam undertook another experiment typical of his knack for creative problem-solving.

Using Federated Computing enabled by CometCloud, the project brought together a team of researchers with access to 10 supercomputers at six high performance computing (HPC) centers across three continents to continue and extend Ganapathysubramaniam’s microfluidics simulations. The consortium included TACC’s new Stampede system, as well as resources from the Department of Energy, FutureGrid, and international HPC centers.

Using the Comet Cloud, the researchers ran 12,845 flow simulations, consuming more than 2.5 million core-hours and generating 400 gigabytes of data over the course of 16 days. [Initial results of the work are published on the Comet Cloud website and a paper about the project is under review.]

“The experiment allowed us to explore an alternate paradigm for doing computational science and demonstrate that we can support applications using this paradigm,” Parashar said. “Many applications have a similar workflow so this could be a model for supporting researchers without all of them going to one resource or another. This could be used to provide compute resources to a wide-range of applications.”

The computations enabled by CometCloud brought Ganapathysubramaniam halfway to his dream of a complete library of microscopic fluid flows. However, the entire library would take much more computing. Fortunately, supercomputers are getting relentlessly faster, and with new technologies come new opportunities for industry, science and medicine.

On the Net:

Cyclospora Parasite Outbreak Taking Place In Iowa And Nebraska

Lee Rannals for redOrbit.com – Your Universe Online

A rare parasite known as Cyclospora derived from fresh vegetables has sickened nearly 80 people.

The outbreak has climbed from 35 people to 80 in just a week in Midwestern states. So far, Iowa and Nebraska are the only states reporting problems.

The parasitic disease spreads through contaminated food and water and can cause unusually long watery diarrhea, which could last up to 57 days if it goes untreated. According to the University of Minnesota, Cyclospora can also cause fatigue, anorexia, bloating, stomach cramps, vomiting, muscle aches, and a low-grade fever.

The Iowa Department of Public Health (IDPH) said that 45 cases of the parasite have been reported in 15 counties, so far. However, the IDPH said that nearly half of the cases have been reported in Linn County.

“Most people’s illness began in mid to late June and at least one person has been hospitalized. Many people report still being ill with diarrhea and some have had relapses,” the IDPH said. “Specific treatment is available (but it is not typically used for more common diarrheal illnesses). Also, very specific laboratory testing (not commonly ordered) must be done to detect Cyclospora.”

According to Nebraska Department of Health and Human Services (NDHHS), Nebraska has identified 35 cases.

“We’re currently investigating and trying to identify the source of infection,” said Leah Brucco-White, a public information officer for NDHHS.

Although health officials haven’t pinpointed the cause of the breakout yet, Iowa’s investigation is pointing to fresh vegetables as the likely culprit. The IDPH said it conducted interviews with patients who have been sick for its investigation. Past Cyclospora outbreaks have been linked to imported produce items like raspberries, basil, snow peas, and mesclun lettuce.

Patricia Quinlisk, MD, MPH, medical director for the IDPH, said investigators were conducting follow-up interviews with sick patients. IDHS has discussed case-control studies, but the sample size needed to help identify a specific fruit or vegetable would need to be large.

Quinlisk said the US Centers for Disease Control and Prevention, as well as other experts, recommend that researchers focus on a cluster analysis when sample sizes are small.

The IDPH issued an epidemiologic alert to clinicians about the Cyclospora outbreak on July 3, when seven cases had been detected. The agency has advised clinicians to test patients for the parasite if they have diarrhea lasting more than a few days accompanied by anorexia and fatigue.

In the past 20 years, only 10 previous Cyclospora infections have been identified in Iowa.

Quadrupole Magnet Test Puts Large Hadron Collider On Track For Upgrade

Lee Rannals for redOrbit.com – Your Universe Online
Scientists have successfully tested a powerful new magnet that will be playing a big role in developing a new beam for CERN’s Large Hadron Collider (LHC).
Researchers collaborated to build a powerful superconducting quadrupole magnet to increase LHC luminosity by an order of magnitude. This new system will help the LHC produce 10 times more high-energy collisions than it was originally designed for.
The HQ02a is the latest in the LHC Accelerator Program’s (LARP) series of High Field Quadrupole magnets with cables of the brittle but high-performance superconductor niobium tin (Nb3Sn). This magnet is able to operate at a higher magnetic field than the final-focus quadrupoles currently operating at the LHC.
According to a recent statement, this new magnet tested at the Fermi National Accelerator Laboratory (Fermilab) was able to achieve all of its objectives.
“Congratulation to all the LARP team for this brilliant result,” said Lucio Rossi, leader of the High Luminosity LHC project at CERN. “The steady progress by LARP and the other DOE supported programs clearly shows the benefits of long-term investments to make serious advances in accelerator technology.”
Eric Prebys of Fermilab, who has served as director of LARP for the last five years, said that this magnet marks the end of the research and development phase and the beginning of focused development of the magnets that will be installed for the LHC luminosity upgrade.
“However, the implications go well beyond that, in that it establishes high performance niobium tin as a powerful superconductor for use in accelerator magnets. This success is a tribute to the skill, hard work, and collaborative spirit of all of the people involved.”
The LHC was able to help scientists finally discover the Higgs boson particle last year, but precise measurements of the God particle have yet to be done. LARP hopes to support CERN’s plan to replace the current focusing magnets in about 10 years as part of the High Luminosity LHC project, which will in turn lead to more precise measurements of the Higgs boson particle.
“The desired performance characteristics were clearly demonstrated by the test recently completed at Fermilab,” says Berkeley Lab’s GianLuca Sabbi, who directed the HQ02 development. “The magnet quickly achieved its design field gradient with low sensitivity to ramp-rate effects. This result was made possible by the expertise and dedication of many scientists, engineers, and technicians at all the collaborating laboratories.”
The scientists said HQ02a’s performance has reaffirmed the key design elements for focusing magnets that will meet the needs of CERN’s High Luminosity upgrade.
“This is a major step forward in reaching our ultimate goals,” said Bruce Strauss, LARP program manager at DOE’s Office of Science. “It should not be regarded as a single accomplishment but rather the realization of a significant number of individual goals in the design, construction, and testing of Nb3Sn beam-line magnets.”

First-Ever 3D Printed Rocket Part Successfully Tested

Lee Rannals for redOrbit.com – Your Universe Online

NASA reports it has successfully tested the first-ever 3D printed rocket component, demonstrating a technology that could eventually lead to more efficient manufacturing of rocket engines.

The US space agency and Aerojet Rocketdyne tested a rocket engine injector made through 3D printing. NASA said this space technology could eventually help save American companies time and money. They were able to demonstrate the ability to design, manufacture and test this highly critical rocket engine component by using selective laser melting manufacturing.

“NASA recognizes that on Earth and potentially in space, additive manufacturing can be game-changing for new mission opportunities, significantly reducing production time and cost by ‘printing’ tools, engine parts or even entire spacecraft,” said Michael Gazarik, NASA’s associate administrator for space technology in Washington. “3-D manufacturing offers opportunities to optimize the fit, form and delivery systems of materials that will enable our space missions while directly benefiting American businesses here on Earth.”

If the type of injector created was done through traditional processes it would have taken more than a year to make. However, using 3D printing, NASA and Aerojet Rocketdyne were able to produce it in less than four months, with a 70 percent reduction in cost.

“Rocket engine components are complex machined pieces that require significant labor and time to produce. The injector is one of the most expensive components of an engine,” said Tyler Hickman, who led the testing at NASA’s Glenn Research Center in Cleveland, Ohio.

Jeff Haynes, Aerojet Rocketdyne’s additive manufacturing program manager, said this feat represents a huge step in application of manufacturing.

“The injector is the heart of a rocket engine and represents a large portion of the resulting cost of these systems. Today, we have the results of a fully additive manufactured rocket injector with a demonstration in a relevant environment.” he said.

The team working on the injector partnered used the Air Force Research Laboratory at Edwards Air Force Base, California. NASA said this laboratory helped provide insight into the spray patterns of additively manufactured injector elements.

“Hot fire testing the injector as part of a rocket engine is a significant accomplishment in maturing additive manufacturing for use in rocket engines,” said Carol Tolbert, manager of the Manufacturing Innovation Project at Glenn. “These successful tests let us know that we are ready to move on to demonstrate the feasibility of developing full-size, additively manufactured parts.”

Bicycle Helicopter Pilot From Canada Wins $250,000 Prize

Michael Harper for redOrbit.com – Your Universe Online
A Canadian team has just won $250,000 for successfully defying gravity with a bicycle-powered helicopter.
Though scientists had long thought the feat to be impossible, the American Helicopter Society (AHS) began offering the prize money to anyone who could lift themselves in the air using only human muscle. The prize had been unclaimed since the Igor I Sikorsky Human Powered Helicopter Competition first began in 1980, 33 years ago.
To win the prize, the team of engineers at the University of Toronto had to hover above ground at a height of more than nine feet for more than 60 seconds. While in flight, the vehicle must remain in an area of 32 feet by 32 feet. The team successfully completed the flight on June 13.
It has taken the AHS nearly a month to decide if the aircraft had met all the correct specifications.
Engineer Dr. Todd Reichert and Cameron Robertson led the team, largely staffed by University of Toronto students. Together they built the Atlas, a flying machine made up of four 65-foot long rotors and powered by a bicycle in the middle. Each of the components are held together by lightweight, carbon fiber tubes. The long, slow spinning rotors were inspired by the Gossamer Albatross — the human-powered aircraft that crossed the English Channel in 1979. The airfoils are made of expanded polystyrene foam and balsa wood and held together with carbon fiber tubing and wire. Each rotor is covered with Mylar plastic film, making them transparent.
Dr. Reichert piloted the Atlas by pedaling the bicycle and spinning the giant blades. As each of the giant blades began to spin, the Atlas slowly rose to a height of ten feet. In an interview with Wired, Reichert explained that though the team had been working for many months to earn the 33 year-old prize, their successful flight was almost delayed due to scheduled practice which was set to take place in the soccer arena where the team was flying the Atlas. In addition to being rushed for time, Reichert also said the biggest problems for the team in earlier, lower altitude tests came mid-flight.
“For us, the dangerous part is coming down from altitude,” said the world record-setting pilot, noting the Atlas tended to get pulled down in its own downward force of pressure. “Climbing is no problem — it’s in the time period between 15 and 40 seconds that is really tough.”
Mike Hirschberg, the executive director of the AHS, said there had been many scientific studies which claimed it was impossible for a human to power a helicopter like Reichert had. At the presentation ceremony last Thursday, Hirschberg said, “Several studies ‘proved’ it was, in fact, scientifically impossible.
“Well, it took a third of a century to prove those skeptics wrong. It took that long for the state of the art of vertical flight to see significant technological advances in lightweight structures, computer-aided design, aeromechanics, and multidisciplinary design optimization,” he explained to The Guardian.
Two other teams were vying for the The Igor I Sikorsky Human Powered Helicopter prize and lost: teams from the University of Maryland in College Park and California Polytechnic State University in San Luis Obispo. The AHS plans to offer “another grand challenge” in the future.

Virtual Brain Capable Of Daydreaming Just As Humans Do

April Flowers for redOrbit.com – Your Universe Online

A team of international researchers, led by Washington University School of Medicine in St. Louis, has created a virtual model of the brain capable of daydreaming like humans do.

The computer model is based on the dynamics of brain cells and the many connections those cells make with their neighbors and cells in other brain regions. The team hopes their model will help further understanding of why certain portions of the brain work together when a person daydreams or is mentally idle. One day, this information should help doctors better diagnose and treat brain injuries.

“We can give our model lesions like those we see in stroke or brain cancer, disabling groups of virtual cells to see how brain function is affected,” said Maurizio Corbetta, MD, the Norman J. Stupp Professor of Neurology at Washington University School of Medicine in St. Louis. “We can also test ways to push the patterns of activity back to normal.”

In the late 1990s to early 2000s, scientists recognized the brain stays busy even when not engaged in mental tasks. Prior research has identified several “resting state” brain networks, which are groups of different brain regions that have activity levels that rise and fall in sync when the brain is at rest. Disruptions in networks associated with brain injury and disease have been linked to cognitive problems in memory, attention, movement and speech.

The new model, described in the Journal of Neuroscience, was developed to help researchers learn how the brains anatomical structure contributes to the creation and maintenance of resting state networks. The team started with a process for simulating small groups of neurons, including factors that decrease or increase the likelihood that a group of cells will send a signal.

“In a way, we treated small regions of the brain like cognitive units: not as individual cells but as groups of cells,” said Gustavo Deco, PhD, professor and head of the Computational Neuroscience Group in Barcelona. “The activity of these cognitive units sends out excitatory signals to the other units through anatomical connections. This makes the connected units more or less likely to synchronize their signals.”

Using data from brain scans, the team assembled 66 cognitive units in each hemisphere of the brain. Then they interconnected them in anatomical patterns similar to the connections present in the biological brain.

The model is constructed so that the individual units went through the signaling process at random low frequencies that had been observed in brain cells in culture and in recordings of resting brain activity.

The model was allowed to run while the researchers slowly changed the coupling, or the strength of the connections between units. At specific coupling values, the interconnections between the units sending impulses began to create coordinated patterns of activity.

“Even though we started the cognitive units with random low activity levels, the connections allowed the units to synchronize,” Deco said. “The spatial pattern of synchronization that we eventually observed approximates very well–about 70 percent–to the patterns we see in scans of resting human brains.”

Simulating 20 minutes of human brain activity required a cluster of powerful computers running the model for 26 hours. The researchers have been able to simplify the mathematics, however, so that the model will run on a typical computer.

“This simpler whole brain model allows us to test a number of different hypotheses on how the structural connections generate dynamics of brain function at rest and during tasks, and how brain damage affects brain dynamics and cognitive function,” Corbetta said.

Lionfish Invasion May Call For Human Intervention

Brett Smith for redOrbit.com – Your Universe Online

With almost daily reports detailing how human activities are decimating other species, researchers from the University of North Carolina are making the unique call for human intervention in controlling the Atlantic Ocean’s lionfish population.

“Lionfish are here to stay, and it appears that the only way to control them is by fishing them,” said John Bruno, a UNC biologist and lead investigator in a new study detailing the lack of lionfish predation that was recently published in the journal PLOS ONE.

Along with a team of fellow American and Canadian marine biologists, the UNC researchers investigated the proliferation of lionfish in three Caribbean regions. Using a deep-diving submersible, the team was shocked to find major populations of these predatory fish as deep as 300 feet below the surface.

“We expected some populations of lionfish at that depth, but their numbers and size were a surprise,” said co-author Stephanie Green, a research fellow at Oregon State University. “This was kind of an ‘Ah hah!’ moment.”

“It was immediately clear that this is a new frontier in the lionfish crisis, and that something is going to have to be done about it,” Green said. “Seeing it up-close really brought home the nature of the problem.”

Native to the Pacific Ocean, lionfish were accidentally introduced to the Atlantic Ocean in the early 1990s. Without any limiting factors in their new habitat, the ravenous predators swarmed across the Caribbean, reducing various native fish populations by up to 80 percent, according to previous OSU research.

“When I began diving 10 years ago, lionfish were a rare and mysterious species seen deep within coral crevices in the Pacific Ocean,” said co-author Serena Hackerott, a master’s student in marine sciences at UNC. “They can now been seen across the Caribbean, hovering above the reefs throughout the day and gathering in groups of up to ten or more on a single coral head.”

A popular aquarium fish, lionfish have venomous spines in addition to their striking colors and majestic fins. The spines generally make lionfish unappealing for most predators. However, they are eaten by humans – once the spines have been removed.

The researchers said they looked to see if sharks or groupers could help control the lionfish population by out-competing them for prey or eating them directly. They also wanted to determine if overfishing of reef predators had opened the door for an unchecked lionfish invasion.

After surveying 71 disparate reefs over three years, the team said they saw no relationship between the density of lionfish and the concentrations of native predators, suggesting that “interactions with native predators do not influence” the lionfish population. They noted, however, that targeted removal by reef managers had reduced lionfish populations in some protected reefs.

The marine biologists suggested the large-scale introduction of reef predators to achieve a better balance and biodiversity for the fragile ecosystems. However, they made pessimistic predictions about the success of such a plan.

“Active and direct management, perhaps in the form of sustained culling, appears to be essential to curbing local lionfish abundance and efforts to promote such activities should be encouraged,” the study concluded.

Two Million Die Each Year As Result Of Air Pollution

Lee Rannals for redOrbit.com – Your Universe Online

According to a study published in the journal Environmental Research Letters, over two million people die every year as a result of air pollution.

Researchers have shown that around 2.1 million deaths are caused each year by a human-caused increase in fine particulate matter (PM2.5). These are tiny particles suspended in the air that can penetrate deep into the lungs, causing cancer and other respiratory diseases. The team also found that around 470,000 die each year as a result of increases in ozone.

“Our estimates make outdoor air pollution among the most important environmental risk factors for health,” said Jason West, from the University of North Carolina and co-author of the study. “Many of these deaths are estimated to occur in East Asia and South Asia, where population is high and air pollution is severe.”

Climate change can affect air pollution because temperature and humidity can change the reaction rates which determine the formation or lifetime of a pollutant, while rainfall determines the time that pollutants can accumulate. Higher temperatures increase the emissions of organic compounds from trees, which can then react in the atmosphere to form ozone and particulate matter.

“Very few studies have attempted to estimate the effects of past climate change on air quality and health. We found that the effects of past climate change are likely to be a very small component of the overall effect of air pollution,” said West.

The researchers used several climate models for the study to help simulate the concentrations of ozone and PM2.5 in the years 2000 and 1850. They used 14 models that simulated levels of ozone and six that simulated levels of PM2.5. The team also used past studies to assess how the specific concentrations of air pollution from the climate models related to current global mortality rates.

The study’s findings fell in line with previous studies that have analyzed air pollution and mortality. However, the latest study had variation depending upon which climate model was used.

“We have also found that there is significant uncertainty based on the spread among different atmospheric models. This would caution against using a single model in the future, as some studies have done,” added West.

Hulking Humanoid Robot Atlas Debuts At Robotics Challenge

[ Watch the Video: Meet Atlas! ]

Brett Smith for redOrbit.com – Your Universe Online

On Monday, the seven engineering teams advancing in the Defense Advanced Research Projects Agency’s (DARPA) Virtual Robotics Challenge got to meet their prize ‘fighter,’ a 6-foot-2-inch robot named ATLAS.

The hulking ATLAS has a humanoid form and online videos showcase the robot’s uncanny sense of balance and locomotion skills.

The teams will have until December to program ATLAS for a series of tasks that might be expected from a first-responder during an emergency situation. The engineers will base their ATLAS programming on algorithms developed for the previous stage of the competition, when they had to create a functioning virtual robot that could operate in a computer-generated environment.

“The Virtual Robotics Challenge was a proving ground for teams’ ability to create software to control a robot in a hypothetical scenario,” said Gill Pratt, program manager for the DARPA Robotics Challenge (DRC). “The DRC Simulator tasks were fairly accurate representations of real world causes and effects, but the experience wasn’t quite the same as handling an actual, physical robot.

“Now these seven teams will see if their simulation-honed algorithms can run a real machine in real environments,” Pratt said. “And we expect all teams will be further refining their algorithms, using both simulation and experimentation.”

While “ATLAS is one of the most advanced humanoid robots ever built,” according to DARPA, the robot’s brains will need to be filled with programs that operate its sensors, actuators, joints and limbs. The seven advancing teams will receive funding from DARPA and tech support from ATLAS developer Boston Dynamics.

In June, DARPA officials met with the competition’s Track A teams, which were funded to create both the software and the hardware for the DRC. During the meetings, Track A teams showed off their designs, hardware components and, in some cases, completed robots. The Track A designs included everything from NASA’s chimp-like RoboSimian to Drexel University’s Hubo, which resembled an astronaut’s suit.

“We have dramatically raised the expectations for robotic capabilities with this Challenge, and brought together a diverse group of teams to compete,” said Pratt. “The progress the Track A teams have made so far is incredible given the short timeline DARPA put in place.

“From here out, it’s going to be a race to the DRC Trials in December, and success there just means the qualifying teams will have to keep on sprinting to the finish at the DRC Finals in 2014,” Pratt added.

The prize for winning the competition is $2 million, but Pratt told the New York Times the real winners will be those who can be helped in the future by robotic first-responders.

“Two weeks ago, 19 brave firefighters lost their lives,” he said. “A number of us who are in the robotics field see these events in the news, and the thing that touches us very deeply is a single kind of feeling which is, can’t we do better? All of this technology that we work on, can’t we apply that technology to do much better? I think the answer is yes.”

Climate Change Has Resulted In More Predation On Mosquito-Eating Birds

April Flowers for redOrbit.com – Your Universe Online

According to the Centers for Disease Control and Prevention (CDC), 286 people were killed in the US in 2012 by West Nile virus, which is carried by mosquitoes. Many bird species eat these mosquitoes and other insects that can be agricultural pests. Rising temperatures are threatening these wild birds, including the Missouri-native Acadian flycatcher, by making snakes more active and hungrier.

University of Missouri biologist John Faaborg led a new study which urges farmers, public health officials and wildlife managers to be aware of complex indirect effects of climate change in addition to the more obvious influences of higher temperatures and irregular weather patterns.

“A warmer climate may be causing snakes to become more active and seek more baby birds for food,” said Faaborg, professor of biological sciences in MU’s College of Arts and Science. “Although our study used 20 years of data from Missouri, similar threats to bird populations may occur around the world. Increased snake predation on birds is an example of an indirect consequence that forecasts of the effects of climate change often do not take into account.”

Cooler temperatures in the heart of Missouri’s Ozark forest usually make snakes less active than those found in the edge of the forest or in smaller pockets of woodland. During abnormally hot years, however, even the deep interior of the forest increases in temperature. Warmer temperatures make cold blooded snakes more active and increase their need for food. Prior studies used video cameras to discover snakes are major predators of young birds.

During the last two decades, research by Faaborg and his colleagues has shown fewer young Acadian flycatchers (Empidonax virescens) and young Indigo buntings (Passerina cyanea) survived during hotter years. One reason for this, the study suggests, is an increase in snake activity.

The findings of the study, published in Global Change Biology, are based on data collected over 20 years of fieldwork performed by Faaborg, his colleagues and former students.

“Low survival in the Ozark nests harms bird numbers in other areas,” Faaborg said. “Birds hatched in the Ozark forest spread out to colonize the rest of the state and surrounding region. Small fragments of forests in the rest of the state do not support successful bird reproduction, so bird populations in the entire state depend on the Ozarks.”

Pedophiles Beware Negobot, A ‘Virtual Lolita’

Enid Burns for redOrbit.com – Your Universe Online

Parents worry about their children falling victim to online predators, but a new solution aims to snare such offenders. Negobot, a software program created by a group of researchers at the University of Deusto in Spain, has seven programs to engage in chat with suspected pedophiles.

The program is being called a “virtual Lolita” by a number of media outlets, including the Huffington Post. Negobot starts chats with suspects in a neutral tone, posing as a 14-year-old girl. The program is adaptive, using an arsenal of artificial intelligence and machine learning to keep the conversation convincing. Triggers can sway the conversation in different directions. Negobot has seven personalities that are typical targets of sexual predators.

“As conversations become more intimate or suggestive, and the ‘target’ begins to employ grooming tactics, Negobot’s behavior changes in ways designed to lure him in,” the Daily Mail reported.

Personalities include insistent and offended. “An attempt to obtain personal information will cause Negobot to try to find out more about the suspect,” the Daily Mail said.

The software represents an advance over previous virtual chat programs, according to the team of creators. In the past, chatbots have been found to be predictable. “Their behavior and interest in a conversation are flat, which is a problem when attempting to detect untrustworthy targets like pedophiles,” said Dr. Carlos Lorden, who contributed to the software work.

“What is new about Negobot is that it employs game theory to maintain a much more realistic conversation,” Dr. Laorden said.

The Negobot uses its artificial intelligence and machine learning to engage in game theory, which activates a convincing chat session. It is, in fact, the game theory that makes Negobot convincing. “It can take the lead in conversations, and remember specific facts about what had been discussed previously, and with whom.” BBC News reported.

Some say the program can help overburdened police, however others fear that the program can trap people unfairly. The Negobot program only provides the chat personality, it is up to the website or platform to determine how to respond. It is not clear whether the program alerts police, or the site’s administrator at least, when engaging in such chats, or if the program is able to suspend accounts and deny access.

Developers at the university were able to create a convincing chat by deploying tricks such as “inserting typos, abbreviations, and deliberate language areas to mimic the actions of a young teenager,” the Daily Mail said.

The program still has some learning to do yet. “Despite having a high degree of artificial intelligence, Negobot’s powers of conversation are still limited, the researchers point out that it is unable to detect linguistic subtleties such as irony, for example,” the Daily Mail said.

Negobot is available for $29.95. Most likely social networks, chat rooms, online games and other Internet hangouts for children will employ the software, rather than individuals. The team worked under a collaborative agreement with Ertzaintza, the Basque Country police force, the Daily Mail reported.

Prisoners Doing Yoga May See Psychological Benefits

Yoga can improve mood and mental well being among prisoners, an Oxford University study suggests, and may also have an effect on impulsive behavior.

The researchers found that prisoners after a ten-week yoga course reported improved mood, reduced stress and were better at a task related to behavior control than those who continued in their normal prison routine.

‘We found that the group that did the yoga course showed an improvement in positive mood, a decrease in stress and greater accuracy in a computer test of impulsivity and attention,’ say Dr Amy Bilderbeck and Dr Miguel Farias, who led the study at the Departments of Experimental Psychology and Psychiatry at Oxford University. ‘The suggestion is that yoga is helpful for these prisoners.’

Dr Bilderbeck adds: ‘This was only a preliminary study, but nothing has been done like this before. Offering yoga sessions in prisons is cheap, much cheaper than other mental health interventions. If yoga has any effect on addressing mental health problems in prisons, it could save significant amounts of public money.’

The researchers were supported in the running of the trial by the Prison Phoenix Trust, an Oxford-based charity that offers yoga classes in prisons. They approached the Oxford University psychologists about conducting such a study to assess the benefits, though the study was designed, analyzed and published independently of the Trust.

The Oxford University researchers, along with colleagues from King’s College London, the University of Surrey and Radboud University Nijmegen in the Netherlands, report their findings in the Journal of Psychiatric Research.

Prisons see rates of mental health problems that are many times higher than the general population, and high levels are often recorded of personal distress, aggression, antisocial behavior and drug and alcohol abuse among prisoners.

Yoga and meditation have been shown be beneficial in reducing anxiety, depression and improving mood in other areas and settings, so the Oxford researchers carried out an initial exploratory study to look at a range of possible benefits of yoga among prisoners.

Inmates of a range of ages were recruited from five category B and C prisons, a women’s prison and a young offender institution, all in the West Midlands, and were randomly assigned to either a course of ten weekly yoga sessions of 90 minutes run by the Prison Phoenix Trust, or to a control group.

In sessions with the researchers before and after the yoga course, all the prisoners completed standard psychology questionnaires measuring mood, stress, impulsivity and mental well being. A computer test to measure attention and the participant’s ability to control his or her responses to an on-screen cue was also used after the yoga course.

If yoga is associated with improving behavior control, as suggested by the results of the computer test, there may be implications for managing aggression, antisocial or problem behavior in prisons and on return to society, the researchers note – though this is not measured in this initial study.

Dr Bilderbeck, who practices yoga herself, cautions: ‘We’re not saying that organizing a weekly yoga session in a prison is going to suddenly turn prisons into calm and serene places, stop all aggression and reduce reoffending rates. We’re not saying that yoga will replace standard treatment of mental health conditions in prison. But what we do see are indications that this relatively cheap, simple option might have multiple benefits for prisoners’ well being and possibly aid in managing the burden of mental health problems in prisons.’

Sam Settle, director of the Prison Phoenix Trust, says: ‘Almost half of adult prisoners return to prison within a year, having created more victims of crime, so finding ways to offset the damaging effects of prison life is essential for us as a society. This research confirms what prisoners have been consistently telling the Prison Phoenix Trust for 25 years: yoga and meditation help them feel better, make better decisions and develop the capacity to think before acting – all essential in leading positive, crime-free lives once back in the community.’

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When Describing Intoxication, Women Use Softer Terms Like ‘Tipsy’

Michael Harper for redOrbit.com – Your Universe Online
When drinking, it can be difficult to accurately describe to anyone else precisely how you are feeling. This isn’t because inebriation has left you without your faculties, however. According to a new study from the University at Buffalo, SUNY, people use different words like “hammered” or “tipsy” to describe their level of intoxication.
More specifically, however, men and women tend to use these words differently to describe how they feel. Not surprisingly, men are more likely to use harder-hitting words like “hammered” or “wasted” while women were found to more often use words like “buzzed” or “tipsy.” Researchers say it’s important to understand how people use these words to make people aware of problem drinking as well as to help them understand when they truly have had too many and shouldn’t drive.
The results of this study will appear in the December 2013 issue of Alcoholism: Clinical & Experimental Research.
“Drinkers use a complex set of physical and cognitive indicators to estimate intoxication,” explained Ash Levitt, a research scientists at the Research Institute on Addictions for the University at Buffalo, SUNY in a statement.
“In order to quickly and easily communicate various levels of intoxication, drinkers distill these indicators down into distinct sets of natural language terms for intoxication, such as ‘tipsy’ or ‘wasted.’ Understanding this language is important as these terms reflect levels of intoxication as well as whether individuals are accurately estimating intoxication levels when they use these terms.”
Levitt has performed this kind of research before, finding that people use different words to describe their level of intoxication depending on how drunk they really were. Yet one observation has remained consistent throughout his studies: Women generally prefer to keep quiet about how intoxicated they are while men are more likely to broadcast their state of inebriation using heavy terms.
“This study’s key findings that men’s drinking, regardless of whether it is moderate or heavy, is described using terms indicative of excessive consumption such as ‘wasted’ or ‘hammered,’ while women tend to couch drinking in more moderate terms such as ‘buzzed’ or ‘tipsy’ corresponds with the way that ‘drinking men’ and ‘drinking women’ are differentially perceived,” explained Mark Wood, a professor of psychology at the University of Rhode Island.
“As such, these findings have clear implications for prevention and intervention work with men and women.”
Furthermore, Levitt’s research found that men and women are more likely to use the same words when judging how drunk others appear to be. After gathering some 145 undergraduate students from an unnamed midwestern university, Levitt asked them to read short situational stories about people drinking. Men and women were equally represented in these stories. When they finished reading, Levitt and crew asked them to describe how drunk they felt the characters would be. Words like “buzzed” were more often used by both men and women when describing a female character. Alternatively, words like “wasted” were more often used by both genders to describe the male characters.
Levitt believes this research is important to help both genders understand when they are truly intoxicated.
“One potential real-world implication that this research suggests is that women may be at increased risk for alcohol-related consequences such as drunk driving if they or their friends underestimate how intoxicated they are by using moderate terms like ‘tipsy’ to describe them when, in fact, they are heavily intoxicated and heavy terms would be more accurate,” said Levitt.
A 2012 study found that an increasing number of women were involved in drunk driving crashes, catching up to men in this regard. If men and women better understand one another and how to accurately describe their levels of intoxication, these drunk driving numbers could potentially come down.

Efficiency In The Forest

Researchers find that a changing atmosphere affects how much water trees require
Spurred by increasing levels of atmospheric carbon dioxide, forests over the last two decades have become dramatically more efficient in how they use water, a Harvard study has found.
Studies have long predicted that plants would begin to use water more efficiently as atmospheric carbon dioxide levels rose. A research team led by Research Associate Trevor Keenan and Assistant Professor of Organismic and Evolutionary Biology Andrew Richardson, however, has found that forests across the globe are becoming more efficient than expected.
Using data collected from forests in the northeastern US and elsewhere around the world, Keenan and Richardson, found increases in efficiency larger than those predicted by even the most state-of-the-art computer models. The research, which was done in collaboration with researchers from the Harvard’s Department of Earth and Planetary Sciences, the USDA Forest Service, Ohio State University, Indiana University, and the Karlsruhe Institute of Technology in Germany, is described in a July 10 paper in Nature.
“This could be considered a beneficial effect of increased atmospheric carbon dioxide,” said Keenan, the first author of the paper. “What’s surprising is we didn’t expect the effect to be this big. A large proportion of the ecosystems in the world are limited by water – they don’t have enough water during the year to reach their maximum potential growth. If they become more efficient at using water, they should be able to take more carbon out of the atmosphere due to higher growth rates.”
While increased atmospheric carbon dioxide may benefit forests in the short term, Richardson emphasized that the overall climate picture would remain grim if levels continue to rise.
“We’re still very concerned about what rising levels of atmospheric carbon dioxide mean for the planet,” Richardson cautioned. “There is little doubt that as carbon dioxide continues to rise – and last month we just passed a critical milestone, 400 ppm, for the first time in human history – rising global temperatures and changes in rainfall patterns will, in coming decades, have very negative consequences for plant growth in many ecosystems around the world.”.
How do increasing carbon dioxide levels lead to more efficient water use?
The answer, Keenan said, is in the way photosynthesis works. To take in the carbon dioxide they need, plants open tiny pores, called stomata, on their leaves. As carbon dioxide enters, however, water vapor is able to escape.
Higher levels of carbon dioxide, however, mean the stomata don’t need to open as wide, or for as long, meaning the plants lose less water and grow faster. To take advantage of that fact, Keenan said, commercial growers have for years pumped carbon dioxide into greenhouses to promote plant growth.
To test whether such a “carbon dioxide fertilization effect” was taking place in forests, Keenan, Richardson and others turned to long-term data measured using a technique called eddy covariance. This method, which relies on sophisticated instruments mounted on tall towers extending above the forest canopy, allows researchers to determine how much carbon dioxide and water are going into or out of the ecosystem.
With more than 20 years of data, the towers in the Harvard Forest – which have the longest continuous record in the world – are an invaluable resource for studying how forests have responded to changes in atmospheric carbon dioxide levels. Though more than 300 towers have since sprung up around the globe, many of the earliest – and hence the longest data record – are in the northeast U.S.
When Keenan, Richardson and colleagues began to examine those records, they found that forests were storing more carbon and becoming more efficient in how they used water. The phenomenon, however, wasn’t limited to a single region – when they examined long-term data sets from all over the world, the same trend was evident.
“We went through every possible hypothesis of what could be going on, and ultimately what we were left with is that the only phenomenon that could cause this type of shift in water-use efficiency is rising atmospheric carbon dioxide,” Keenan said.
Going forward, Keenan (now based at Macquarie University in Sydney, Australia) said he is working on a proposal to get access to data collected from even more sites around the world, including several that monitor tropical and Arctic systems.
“This larger dataset will help us to better understand the extent of the response we observed,” he said. “That in turn will help us to build better models, and improve predictions of the future of the Earth’s climate. Right now, all the models we have under-represent this effect by as much as an order of magnitude, so the question is: What are the models not getting? What do they need to incorporate to capture this effect, and how will that affect their projections for climate change?”

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New Research Challenges 50 Years Of Muscle Knowledge

Michael Harper for redOrbit.com – Your Universe Online

For the past 50 years, scientists and health professionals have operated with the knowledge that biceps are packed with long ropes of filaments. When the bicep is used to lift a heavy object or flex, these filaments were understood to shorten or contract the muscle and give it its power.

A new study from the University of Washington (UW) challenges this notion, saying that while the general idea of filaments contracting is the same, the shape of these filaments is quite different. Instead of long strands of contracting and shortening filaments straight up and down the length of the muscle, a mesh arrangement of filaments spreads out across the muscle.

According to C. David Williams, a postdoctoral researcher at Harvard who earned his doctorate while at UW, this action is responsible for the muscle force measured by scientists for years. The new study is published in the Royal Society journal Proceedings of the Royal Society B.

The predominant thinking of the last 50 years is that 100 percent of the muscle force comes from changes as muscles shorten and myosin and actin filaments overlap. But when we isolated the effects of filament overlap we only got about half the change in force that physiologists know muscles are capable of producing,” said Williams.

The mesh of filaments fans out into a lattice that is also responsible for the lifting power of biceps and the force generated by other muscles. Williams’ discovery doesn’t only cover the shape of the filaments in the muscles.

According to Thomas Daniel, a professor of biology at UW and co-author of the resulting paper, this discovery could have long lasting ramifications on the understanding of muscles in the body.

“One of the major discoveries that David Williams brought to light is that force is generated in multiple directions, not just along the long axis of muscle as everyone thinks, but also in the radial direction. This aspect of muscle force generation has flown under the radar for decades and is now becoming a critical feature of our understanding of normal and pathological aspects of muscle,” said Daniel.

To better understand his new hypothesis, Williams created a 3D computer model to see the geometry and physics at work inside a muscle wrapped in mesh filament. According to Williams, his research wouldn’t have been possible without the ability to render these computer models and watch the way these filaments work together. With these computer models in place, the research team then validated their hypothesis with the flight muscle of a moth. This muscle has been compared to the human cardiac muscle in the past. The same lattice spacing effect occurred in the flight muscle, leading the team to believe that the same effect can be seen in other muscles of the body as well.

“In the heart especially, because the muscle surrounds the chambers that fill with blood, being able to account for forces that are generated in several directions during muscle contraction allows for much more accurate and realistic study of how pressure is generated to eject blood from the heart,” said co-author Michael Regnier.

“The radial and long axis forces that are generated may be differentially compromised in cardiac diseases and these new, detailed models allow this to be studied at a molecular level for the first time.”

New Observations Give Peek Into Massive Star Formation


[ Watch the Video: Zooming in on the Birth of a Monster Star ]

Lee Rannals for redOrbit.com – Your Universe Online

Astronomers used ESO’s Atacama Large Millimeter/submillimeter array (ALMA) to gain one of the best views yet of a star in the process of forming.

The embryonic monster star sits inside Spitzer Dark Cloud (SDC) 335.579-0.292 right now, which contains over 500 times the mass of the Sun. Astronomers say the cloud will be giving birth to a very brilliant star with up to 100 times the mass of the Sun. The brightest stars in the galaxy form within cool and dark clouds, but the processes are both shrouded in dust and a mystery.

The team used ALMA to perform a microwave prenatal scan to get a clearer look at the formation of the star. There are two theories on how massive stars like this begin to form. One is that the parental dark cloud fragments create several small cores that collapse on their own and eventually form stars. The other says the entire cloud begins to collapse inwards, with material racing towards the cloud’s center to form one or more massive stars.

This new observation supports the theory of global collapse for the formation of massive stars, rather than fragmentation.

“The ALMA observations reveal the spectacular details of the motions of the filamentary network of dust and gas, and show that a huge amount of gas is flowing into a central compact region,” said team member, Ana Duarte Cabral from the Laboratoire d’Astrophysique de Bordeaux, France.

Scientists first spotted SDC335.579-0.292 as a dramatic environment of dark, dense filaments of gas and dust through observations with NASA’s Spitzer Space Telescope and the European Space Agency’s (ESA) Herschel Space Observatory. The team used ALMA to look at the forming star in detail, observing the amount of dust and the motion of the gas moving around within the dark cloud.

“The remarkable observations from ALMA allowed us to get the first really in-depth look at what was going on within this cloud,” says Nicolas Peretto of CEA/AIM Paris-Saclay, France. “We wanted to see how monster stars form and grow, and we certainly achieved our aim! One of the sources we have found is an absolute giant – the largest protostellar core ever spotted in the Milky Way.”

The star’s core has over 500 times the mass of our Sun swirling around within it, and the ALMA observations show that much more material is still flowing inwards and increasing the mass still further. This material will eventually collapse to form the giant star.

“Even though we already believed that the region was a good candidate for being a massive star-forming cloud, we were not expecting to find such a massive embryonic star at its center,” says Peretto. “This object is expected to form a star that is up to 100 times more massive than the Sun. Only about one in ten thousand of all the stars in the Milky Way reach that kind of mass!”

Gary Fuller from the University of Manchester, UK said that not only are these stars rare, but their birth is extremely rapid, so finding such a massive object is a “spectacular result.”

This research was presented in a paper entitled “Global collapse of molecular clouds as a formation mechanism for the most massive stars” and is scheduled to appear in Astronomy & Astrophysics.

Salk Researchers Identify Potential Biomarker For Cancer Diagnosis

Findings of disrupted micronuclei may prove to be a valuable tool for detecting cancer

Scientists studying cancer development have known about micronuclei for some time. These erratic, small extra nuclei, which contain fragments or whole chromosomes that were not incorporated into daughter cells after cell division, are associated with specific forms of cancer and are predictive of poorer prognosis.

In a new study, published on July 3 in Cell, a team of scientists at the Salk Institute for Biological Studies finds that disrupted micronuclei, which can trigger massive DNA damage on chromosomes, might play an even more active role in carcinogenesis than previously thought. They also found that disrupted micronuclei can be an objective biomarker for the genetic instability common to many solid tumors, including non-small cell lung cancer (NSCLC).

“Our study shows that more than 60 percent of micronuclei undergo catastrophic dysfunction in solid tumors such as NSCLC,” says Martin Hetzer, a professor in Salk’s Molecular and Cell Biology Laboratory and holder of the Jesse and Caryl Phillips Foundation Chair. “We identified disrupted micronuclei in two major subtypes of human non-small cell lung cancer, which suggests that they could be a valuable tool for cancer diagnosis.”

As a result of a glitch in cell division, whole chromosomes can sometimes end up outside the nucleus. During normal division, a cell duplicates its chromosomes and sends them to two newly formed daughter cells. One set of chromosomes goes to each daughter cell, but, for a variety of reasons, the chromosomes sometimes are not divided evenly, with one cell receiving an extra set and the other cell coming up short. These lagging chromosomes, which acquire their own nuclear membrane and are called micronuclei, often don’t make it to the nucleus, ending up elsewhere within the cell and becoming wrapped in their own nuclear envelope. Micronuclei appear at a higher frequency in cancer cells.

In their study, Hetzer and his team found that during a certain phase of cancer cell division previously undetected defects in the nuclear lamina, filaments that provide support and stability to the cell’s nucleus, cause the nuclear envelope surrounding micronuclei to catastrophically collapse, leading to the loss of basic nuclear functions such as replication, transcription, and DNA damage recognition and repair. More than 60 percent of micronuclei undergo this irreversible loss of function following nuclear envelope collapse, precipitating cancer-causing aneuploidy, the accumulation of an abnormal number of intact chromosomes within cancer cells.

“In the micronuclei,” says Emily Hatch, a research associate in the Hetzer laboratory, “we saw holes developing in the lamina. We think the membrane has no support at the site of these holes, so it weakens and ruptures. We don’t fully understand why this happens in micronuclei.”

Previous studies have found that the DNA damage and arrest of gene transcription caused by nuclear envelope collapse can promote aneuploidy. This damaged DNA can then enter the next generation of daughter cells and undergo chromothripsis, a rearrangement of genomic information in one chromosome, which leads to massive DNA damage and the formation of tumors.

In the current study, Hatch identified biomarkers to identify disrupted micronuclei, which may greatly increase pathologists’ ability to recognize these structures in tumor sections. Currently, few objective markers exist to detect genomic instability in solid tumors, she says, although several cancers rely on the identification of aneuploidy.

“Our ability to identify disrupted micronuclei in solid tumors suggests a new way to evaluate aneuploidy in these tissues,” adds Hetzer, who says that it is not clear if all or how many cancers are affected by disrupted micronuclei. In addition to NSCLC, scientists believe that micronuclei disruption may play a role in bone cancer, melanoma and other forms of lung cancer.

Because they are strongly correlated with mitotic errors, micronuclei are regarded as an accurate indicator of genomic stability and aneuploidy, two hallmarks which characterize non-small cell lung cancer. Hetzer’s team found disrupted micronuclei in pulmonary adenocarcinomas, the most common form of primary lung cancer and roughly 50 percent of all NSCLCs, and squamous cell carcinomas, which make up about 30 percent of NSCLCs.

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Ocean Acidification Has Transformed Delicate Ecosystem

Brett Smith for redOrbit.com – Your Universe Online
While many studies have focused on how ocean acidification may impact various individual species, an international team of researchers has just published a study on how an entire ecosystem can be affected by a more acidic ocean.
As one of the consequences of climate change, ocean acidification is expected to significantly increase if carbon emissions continue at current rates.
According to the study, which was published in Proceedings of the National Academy of Sciences (PNAS), ocean waters with higher levels of acidity will result in ecosystems with less diversity.
“The background, low-grade stress caused by ocean acidification can cause a whole shift in the ecosystem so that everything is dominated by the same plants, which tend to be turf algae,” said lead author Kristy Kroeker, a postdoctoral researcher at the Bodega Marine Laboratory at the University of California, Davis.
“In most ecosystems, there are lots of different colorful patches of plants and animals — of algae, of sponges, of anemones,” Kroeker explained. “With ocean acidification, you lose that patchiness. We call it a loss of functional diversity; everything looks the same.”
To reach their conclusion, the research team headed to Castello Aragonese, a 14th century castle off the western coast of Italy, at the northern end of the Gulf of Naples.
In the waters near the castle, natural volcanic vents release carbon dioxide gas, which creates a gradient of different levels of acidity for the surrounding area. This gradient allowed the research team to get a first-hand view of how increasingly acidic waters might look across time and how ecosystems may react to them.
First, the researchers selected three reef zones: low, high and extremely high acidity. Each area was used to represent world ocean conditions for the present day, 2100 and 2500, respectively. Next, the team removed animals and vegetation from the rocks in all three zones. Over the course of three years, Kroeker would dive to the different study regions every three months to photograph them and see how each recovered.
After analyzing the different recoveries among all three zones, the team found that the two regions with higher acidity recovered with a reduced number and variety of species.
In particular, they noted that turf algae would colonize and grow in the low acidity zone, only to be preyed upon by sea urchins and snails, which eventually allowed for increased diversity over time.
However, in the more acidic regions, the turf algae would grow to dominate the zones, as grazers avoided the area or did not prey on the algae while in these areas.
Known as calcareous grazers, sea urchins and snails play key roles in establishing and maintaining the balance within marine ecosystems. These species are also considered among the most susceptible to ocean acidification.
“Our research is showing that if the role of these grazers changes with ocean acidification, you might expect to see cascading effects of the whole ecosystem,” Kroeker said. “If the pattern holds for other calcareous grazers, this has implications for other ecosystems, as well.”

Late Or Early Introduction Of Solid Foods Linked To Diabetes In Infants

Brett Smith for redOrbit.com – Your Universe Online

Deciding when to switch an infants diet from liquid to solid food can be a tough choice for any mother. Now, a new study from researchers at the University of Colorado indicates babies who are given solid food before 3 months of age and after 6 months of age could be at an increased risk for developing type 1 diabetes mellitus (T1DM).

According to the study which was published in JAMA Pediatrics, the best time to introduce solid foods into an infant’s diet is between the ages of 4 and 5 months and in conjunction with breastfeeding.

While the study focused on children who had a genetic predisposition for the disease, the researchers said they were unsure of the mechanism behind the increased risk associated with early or late introduction of solid food.

“The risk predicted by early exposure to solid foods might suggest a mechanism involving an abnormal immune response to solid food antigens in an immature gut immune system in susceptible individuals,” the authors wrote. “As the increased risk is not limited to a specific food, it is possible many solids, including cereals and fruits, contain a common component that triggers an immature response.”

“Additionally, the increased risk predicted by late exposure to solid foods may be related to the cessation of breastfeeding before solid foods are introduced, resulting in a loss of the protective effects of breast milk at the introduction of foreign food antigens.”

In the study, the researchers checked for a predisposition via the screening of umbilical cord blood with respect to the human leukocyte antigen (HLA) at St. Joseph’s Hospital in Denver. They also recruited first-degree relatives of persons with T1DM.

In total, the study followed over 1,800 children with an increased genetic disposition for T1DM. The research team considered a first exposure to solid food early if it was given before 4 months of age and late if given at 6 months or later. Researchers reported 53 children in their study cohort were diagnosed with T1DM.

After compensating for genetic factors, first-degree relatives with the condition, mother’s education level and delivery type, the Colorado scientists found early exposure was linked to a doubling of risk, while late exposure increased the risk three-fold.

The study also found early exposure to fruit and late exposure to rice or oat products more than doubled T1DM risk. A complicated vaginal delivery was also linked to an approximately doubled risk increase. However, breastfeeding at the time of wheat or barley exposure appeared to cut the risk for type 1 diabetes in half.

“Our data suggest multiple foods/antigens play a role and that there is a complex relationship between the timing and type of infant food exposures and T1DM risk,” the authors wrote in conclusion.

“In summary, there appears to be a safe window in which to introduce solid foods between 4 and 5 months of age; solid foods should be introduced while continuing to breastfeed to minimize T1DM risk in genetically susceptible children,” they added. “These findings should be replicated in a larger cohort for confirmation.”

Colon Cancer Cells Thrive On Foul-Smelling Hydrogen Sulfide Gas

redOrbit Staff & Wire Reports – Your Universe Online

Hydrogen sulfide, the foul-smelling gas produced by rotten eggs, plays a key role in colon cancer metabolism and is a potential target for new treatments for the disease, researchers from the University of Texas Medical Branch at Galveston (UTMB) have discovered.

In a paper appearing in this week’s online edition of the Proceedings of the National Academy of Sciences, the UTMB researchers describe how their cell-culture and mouse experiments illustrated colon cancer cells produce large amounts of the colorless, corrosive and flammable chemical compound.

In fact, the cancer cells rely on the gas for their growth and survival, according to author and professor Csaba Szabo. “They love it and they need it,” he said. “Colon cancer cells thrive on this stuff – our data show that they use it to make energy, to divide, to grow and to invade the host.”

Szabo and his colleagues linked the majority of hydrogen sulfide produced in colon-cancer cells to a protein known as CBS. This protein is produced at much higher levels in these cancerous cells than in health tissue, the researchers said. However, when CBS was chemically blocked, colon cancer tissue growth was halted while the growth rate of non-cancerous tissue was unaffected.

Furthermore, they observed the anti-colon cancer effects of blocking the protein when studying “nude” mice onto which patient-derived cancer tumor cells had been implanted. Without hydrogen sulfide, the tumors grew far less quickly, while also displaying a pronounced decrease in angiogenesis – the process by which a tumor stimulates the growth of a host’s blood vessels around itself to essentially hijack oxygen and nutrients for its own use.

“Our work identifies CBS as a new anti-cancer target. By blocking CBS, we can fight colon cancer,” said UTMB professor and study author Mark Hellmich. “This is a chance to do research that really matters. We’re very excited to have that opportunity.”

In addition to Szabo and Hellmich, authors of the study include UTMB associate professor Celia Chao, postdoctoral fellows Ciro Coletta and Katalin Modis, assistant professor Bartosz Szczesny and adjunct professor Andreas Papapetropoulos.

The research was funded by the John Sealy Memorial Endowment Fund, the McLaughlin Foundation, the American Heart Association, the US National Institutes of Health (NIH), the European Union (EU) and the Greek national fund.

Calcium Carbonate From Earthworm Poop Provides A Good Measurement Of Past Climate

Susan Bowen for redOrbit.com – Your Universe Online

A recent discovery about earthworm excrement could help scientists improve our models of future climate change. Most earthworms excrete balls of calcium carbonate crystals, a chalk-like material. What makes these crystals interesting is that they retain a memory of the temperature at which they were created.

Scientists at the Universities of Reading and York conducted an experiment in which earthworms were kept at differing temperatures and their excretions measured using isotopic testing. These modern earthworms produced chalk balls that maintained a record of the temperature at which they were created.

Principal Investigator, Professor Mark Hodson, stated, “There are many conflicting theories about why earthworms produce calcite granules, but until now, the small lumps of chalk-like material found in earthworm poo have been seen as little more than a biological curiosity. However, our research shows they may well have an important role to play, offering a window into past climates.”

These chalky crystals are commonly found at archeological sites, and will help archaeologists in determining the climatic context of their finds. They will also provide an additional way of determining what the climate was like in ages past. Scientists are now gathering samples from archaeological sites that are thousands of years old for sampling.

Climate data using instruments only goes back about 150 years. Prior to that period other methods have to be used. In addition to human records, scientists use such techniques as measuring tree rings and ice cores and analyzing pollen distribution.

Adding earthworm poop to the arsenal has several advantages. Tree ring thickness, for example, can be influenced by other things besides climate, including the clearing of surrounding trees. In addition, many of the other methods may use samples that are thousands of miles from the archaeological site. These chalk deposits are right there in the exact same context as the surrounding dig site. This proximity will provide data on more localized environments and increase the accuracy of the climate data at any given place.

The part of the value of this localized data will be in improving current climate models. In an article in the journal Geochimica et Cosmochimica Acta, lead author Dr Emma Versteegh explains, “This knowledge about past climates is of vital importance for developing and benchmarking climate models that make predictions for the future. Many different proxies already exist, but no proxy is perfect, or is available in every location, so it is good to have many different ones.”

The more accurately we are able to measure climate fluctuations in the past and their consequences, the better we will be able to predict what might befall our planet in the future.

Low Cost IVF Feasible, Effective For Developing Countries

Lee Rannals for redOrbit.com – Your Universe Online

Belgium researchers have shown that low-cost In vitro fertilization (IVF) for developing and poor countries is feasible and effective.

The investigators suggest that infertility care may not be “universally accessible,” showing that a simplified IVF cycle could cost just $250.

“We showed that the IVF methodology can be significantly simplified and result in successful outcomes at levels that compare favorably to those obtained in high resource programs,” the study authors reported at the annual meeting of the European Society of Human Reproduction and Embryology (ESHRE).

Investigator Dr. Elke Klerkx from the Genk Institute for Fertility Technology, Belgium, said that infertility care is probably the most neglected healthcare problem in developing countries, affecting more than two million couples. The low-cost IVF system tested was based on an embryo culture method that removes the need for an expensive IVF laboratory with CO2 incubators, medical gas supply and air purification systems.

The researchers studied IVF patients under the age of 36 with at least eight oocytes available for fertilization. The primary outcome measure was embryo quality at day three, while secondary outcomes were embryo implantation rate and ongoing pregnancy rate.

An analysis of outcomes showed similar rates of fertilization and embryo cleavage in both groups. However, 23 out of 35 cycles assessed the top quality embryo selected by an independent embryologist originated from the simplified culture system. The low-cost group implantation rate was 34.8 percent, with an ongoing pregnancy rate of 30.4 percent.

“Our initial results are proof of principle that a simplified culture system designed for developing countries can offer affordable and successful opportunities for infertility treatment where IVF is the only solution,” said Klerkx “This is a major step towards universal fertility care. If combined with single embryo transfer and low stimulation protocols, we estimate the cost of a treatment cycle can be less than 200 euro – with laboratory costs between 10 percent and 15 percent of those in Western-style programs.”

She warned that the low cost would only be possible if a low-cost laboratory based on the simplified culture system were available.

“In developed countries the cost of setting-up a high-quality IVF lab is between [$1.9 million to $3.8 million US], but we would expect to set up a low-cost lab for less than [$386,000 US],” explained Klerkx.

Elke added the simplified lab procedure will open up a new era in the history of IVF.

“The method not only offers affordable and successful access to IVF, but will make effective treatment techniques available to a much larger part of the world’s infertile population,” Klerkx concluded. “This, therefore, may also be considered an important breakthrough in terms of human rights, equity and social justice.”

First Test-Tube Baby Born Using New Genetic Screening Technique

Brett Smith for redOrbit.com – Your Universe Online

Next generation sequencing (NGS) techniques have allowed scientists to sequence DNA at faster rates than ever before, and in the process they have begun to revolutionize fields as disparate as anthropology and botany.

The technology is also now being used to screen embryos for in vitro fertilization (IVF), and the first child to ever pass though that screening process was recently born in the United States.

Developed in the UK at the University of Oxford, the embryo screening process is designed to scan the embryo for genetic abnormalities that could lead to a miscarriage, defective genes or mitochondrial DNA mutations.

“Next generation sequencing provides an unprecedented insight into the biology of embryos,” said Dr. Dagan Wells at Oxford’s Biomedical Research Centre, who helped to develop the screening process and reported on the child birth at the annual meeting of the European Society of Human Reproduction and Embryology.

The screening process could have massive implications for women seeking IVF as about only 1 in 3 attempts are successful. Chromosomal abnormalities often prevent the successful implantation of an embryo in the womb or the pregnancy being successfully carried to full term. These problems often increase with the woman’s age.

Some fertility clinics already offer an embryo screening service, but it typically adds thousands of dollars to the procedure. The NGS test is expected to be considerably cheaper and quicker – producing results in about 24 hours.

“Current tests are adding a significant amount of money on to an already expensive procedure and that is limiting access; most patients are having to pay for this out of pocket themselves,” Wells told BBC News. “What our technique does is it gives you the number of chromosomes and other biological information about the embryo at a low cost – probably about two thirds of the price of existing methods of screening.”

According to reports, Marybeth Scheidts and her husband David Levy had been trying to conceive a child for four years before visiting the Pennsylvania clinic where the groundbreaking IVF procedure took place. Three of the 13 embryos produced at the clinic were healthy – meaning the odds were against doctors picking a good embryo without the screening process.

“It takes its toll, there were some days I would break down and cry, I wanted to hide in my bedroom and say stop,” she told the BBC. “Then to see him … all this hard work and we have finally got our little tiny human being named Connor.”

Dr. Michael Glassner, a doctor at Main Line Health System where the procedure took place, said he expects this type of embryo screen to become more common in the coming years.

“If you have ever sat across the desk from a patient that has failed or is in that crossroads of thinking of another cycle and you look in their eyes where they are barely able to hold on to their hopes and dreams – anything that is so significantly going to impact pregnancy rates is going to become standard,” said Glassner.

“So I think five years from now you fast forward – yes I think it will be standard.”

Chinese Beachgoers Undeterred By Largest-Ever Algal Bloom

redOrbit Staff & Wire Reports – Your Universe Online

It may be called the Yellow Sea, but the northern part of the East China Sea has turned green due to the largest algal bloom in the history of the Asian nation, various media outlets are reporting.

According to AFP news agency reports, the State Oceanic Administration is reporting that the algae, which is known as Enteromorpha prolifera, started appearing about one week ago, and among the places affected are a public beach in Qingdao, northeast China’s Shandong province.

Pictures have surfaced showing beach-goers swimming and enjoying the sunshine at the beach – undeterred by the algal bloom, which had spread across an 11,158 square mile (28,900 square kilometer) area. Previously, the largest aggregation of Enteromorpha prolifera was 5,019 square miles (13,000 square kilometers) in 2008.

“Officials in the city of Qingdao had used bulldozers to remove 7,335 tons of the growth from beaches,” said Karl Mathiesen of the Guardian. While the algae is not toxic to people or animals, Mathiesen said “the carpet on the surface can dramatically change the ecology of the environment beneath it. It blocks sunlight from entering the ocean and sucks oxygen from the water suffocating marine life.”

In fact, not only is Enteromorpha prolifera harmless, it is actually edible, according to the Daily Mail‘s Steve Nolan. The algae are also known as “sea lettuce,” he said, and is “rich in magnesium and many other nutrients, a vitamin-rich food source that can help improve skin and lower blood pressure.”

However, clean-up crews are nonetheless working hard to clean up the algal masses, because it can produce large amounts of the toxic gas hydrogen sulphide as it decomposes and begins to rot, Nolan said.

Where did all of the algae come from? University of Cambridge and EnAlgae Project researcher Dr. Brenda Parker told the Guardian that algae thrive on an abundance of nutrients in the water, and that the massive blooms could be the result of unnatural ecosystem changes, possibly due to industrial pollution.

“Algal blooms often follow a massive discharge of phosphates or nitrates into the water. Whether it’s farming, untreated sewage or some kind of industrial plant that is discharging waste into the water,” Parker said. “That would probably be an indicator that something is a little bit unbalanced.”

“Officials have blamed warm seas for bringing in the algae in the past, but many scientists blame pollution for the phenomenon,” added Nolan. “Some experts say that the algae blooms in water with high levels of nutrients blaming farmers using too much fertilizer on their crops and cities failing to treat sewage properly.”

Brain Epigenome Continues To Change Through Developmental Years

Brett Smith for redOrbit.com – Your Universe Online
While the entire genome has been sequenced and the codes of many genes have been identified, there are is a wide range of unknown mechanisms that interact with the code without changing “letters” of the DNA. These chemical changes to DNA are referred to as the epigenome, and a new study in the journal Science has revealed significant epigenomic activity during brain development.
DNA includes four chemical bases: adenine (A), guanine (G), cytosine (C), and thymine (T). An epigenomic process known as DNA methylation usually occurs where a cytosine base sits next to a guanine base in the DNA chain, known as CpG sites.
Previous research has shown in human embryonic stem cells and certain types of stem cells, DNA methylation also occurs when G does not follow C, a phenomenon called “non-CG methylation.” This type of methylation was thought to disappear when stem cells later differentiate into specific body cells. However, the new study showed non-CG methylation appears in the brain’s neurons long after stem cell differentiation, usually during childhood and adolescence when the brain is developing.
The scientists reached their findings by sequencing the genomes of mouse and human brain tissue, including neurons and glial cells taken during various life stages.
“This shows that the period during which the neural circuits of the brain mature is accompanied by a parallel process of large-scale reconfiguration of the neural epigenome,” said co-author Joseph R. Ecker, professor and director of Salk Institute’s Genomic Analysis Laboratory.
“The human brain has been called the most complex system that we know of in the universe,” said co-author Ryan Lister, who worked in Ecker’s laboratory at Salk and is now a group leader at The University of Western Australia. “So perhaps we shouldn’t be so surprised that this complexity extends to the level of the brain epigenome.
“These unique features of DNA methylation that emerge during critical phases of brain development suggest the presence of previously unrecognized regulatory processes that may be critically involved in normal brain function and brain disorders.”
The researchers said the construction of networks within the brain requires a long maturation process in which brain cells need to tweak the way they express their genetic code.
“DNA methylation fulfills this role,” said study co-author Terrence J. Sejnowski, head of Salk’s Computational Neurobiology Laboratory. “We found that patterns of methylation are dynamic during brain development, in particular for non-CG methylation during early childhood and adolescence, which changes the way that we think about normal brain function and dysfunction.”
The team noted their study could form a critical foundation for exploring how methylation patterns may be linked to psychiatric disorders or other diseases. Some recent studies have shown DNA methylation playing a role in schizophrenia, depression, suicide and bipolar disorder.
“Our work will let us begin to ask more detailed questions about how changes in the epigenome sculpt the complex identities of brain cells through life,” said co-author Eran Mukamel, from Salk’s Computational Neurobiology Laboratory.
The study researchers said their future work will focus on determining whether minor alterations in the DNA methylation process could be associated to neurodevelopmental disorders.

Neutral Spider Web Seeking Positively Charged Insects

[ Watch the Video: Falling Insects Electrostatically Deform Web ]

Michael Harper for redOrbit.com – Your Universe Online

A new study from the University of California claims spider webs don’t attract the prey; rather, the prey attracts the web. As insects such as aphids or bees fly through the air, carried by their tiny and quickly beating wings, they build up a positive electrostatic charge. This charge may be enough to attract the thin and flexible strands of spider’s silk which contains a neutral or negative charge.

According to Victor Manuel Ortega-Jimenez, a post-doctorate fellow at the University of California Berkeley (UC Berkeley), sticky spider’s silk gets some help from static electricity in the effort to ensnare passing insects. Furthermore, he now wonders if the lighter form of silk eventually developed due to its light weight and ability to deform and come away from the web to grab hold of passing insects. Ortega-Jimenez’s work is now published in the journal Scientific Reports.

“Electrostatic charges are everywhere, and we propose that this may have driven the evolution of specialized webs,” said Ortega-Jimenez in a statement.

He normally studies the way hummingbirds fly but says he became interested in a potential positive charge on insect’s wings when he was playing with his young daughter.

“I was playing with my daughter’s magic wand, a toy that produces an electrostatic charge, and I noticed that the positive charge attracted spider webs,” he said. “I then realized that if an insect is positively charged too it could perhaps attract an oppositely charged spider web to affect the capture success of the spider web.”

A flying insect’s wings will naturally build up a positive charge as they push through the air. As the wings beat against air molecules, friction is built up, resulting in a positive charge. In some ways this phenomenon is similar to walking across a carpet on a dry day just before touching a doorknob. When we experience a build-up of positive charge, we can see a spark leap from the metal door knob. When bees experiences the same type of charge (on a markedly smaller scale), they’re able to attract pollen to their legs when they land on flowers.

As it can sometimes be tricky to coerce a bee to fly into a spider’s web (and even harder to document it), Ortega-Jimenez worked with dead insects such as aphids, bees and fruit flies. He then applied a positive charge to the dead bugs with an electrostatic generator and dropped them on neutral spider webs in a lab environment.

“Using a high speed camera, you can clearly see the spider web is deforming and touching the insect before it reaches the web,” said Ortega-Jimenez. In the high speed photos and videos, tiny strands of thinner silk are reaching out like the positive peaks of a sound wave.

“You would expect that if the web is charged negatively, the attraction would increase.” He pointed out this attraction between web and bug is not observed when the insects are not positively charged.

This effect would not be seen if it weren’t for the different types of silk a spider produces. The thicker and more resilient silk used to create the spokes give the web its strength and structure which a thinner and more flexible silk fill it out. This new study suggests this finer silk may do more than just add some surface area to the overall web; it also reaches out and grabs an attractive insect passing by.

FDA Could Allow Generic Drugmakers To Update Safety Labels

redOrbit Staff & Wire Reports – Your Universe Online

The US Food and Drug Administration (FDA) could soon allow generic drug manufacturers to change safety labels on their medications to reflect updated safety information.

The agency announced the proposed new rule on Wednesday, and according to Katie Thomas of the New York Times, it could open the door for these pharmaceutical companies to be targeted by lawsuits for the first time since such actions were prohibited by the US Supreme Court two years ago.

“Consumer advocates applauded the development, calling it a necessary fix for a system that they say is unfair to patients who take generic medicines,” Thomas reported.

Likewise, Dr. Sidney M. Wolfe, a senior adviser to the Health Research Group at Public Citizen told the Times the rule changes were “common sense” and would allow individuals who were physically harmed by generic drugs to go to “court and get redress for serious damages.”

Under the current system, manufacturers of generic medications are prohibited from updating the safety information on their drug labels, even if they discover a potential issue that is not included on the existing one, according to a Reuters report. The new FDA proposal, however, would allow such changes to be made, and would require all manufacturers of a given drug to carry uniform warnings if the agency approved a revision issued by any one of them.

“It is a first step toward acknowledging that there is a problem with the current system,” attorney Michael Johnson, representing one of the patients who sued generic drug companies in the 2011 Supreme Court case, told Thomas. “It doesn’t make sense to have one set of rules for the name brand and another set of rules for the generics.”

Ralph Neas, president of the Generic Pharmaceutical Association, disagrees, telling Aubrey Pringle of Medill News Service, “Decisions on safety and efficacy of prescription drugs should rest in the hands of the FDA, the only body with the scientific knowledge, regulatory experience and complete data that is needed to make these decisions.”

The FDA told Pringle the rule changes would make generic and brand-name drugmakers equal when it came to updating warning labels. The notice was posted Wednesday on the Office of Management and Budget website, Thomas said, and indicates the FDA intends to publish a proposed rule by September. A period of public comment would begin shortly thereafter, she added.

Moths Emit Sonic Pulses To Jam Bat Echolocation Systems

Brett Smith for redOrbit.com – Your Universe Online

For years, the military has used radio signals to jam an enemy’s radar and a new study in the journal Biology Letters suggests hawk moths use the same technique to evade predation by bats.

According to the study’s authors from the University of Florida, hawk moths emit sonic pulses from their genitals in response to the high-frequency echolocation that bats produce to locate prey.

“This is just the first step toward understanding a really interesting system,” said study co-author Akito Kawahara, assistant curator of Lepidoptera at the Florida Museum of Natural History.

“Echolocation research has been focused on porpoises, whales and dolphins,” he continued. “We know some insects produce the sounds, but this discovery in an unrelated animal making ultrasound, potentially to jam the echolocation of bats, is exciting.”

Hawk moths are a favorite insect among researchers and particularly geneticists due to their large size. The study was conducted in Malaysia, which holds the highest level of diversity for hawk moths anywhere in the world.

Previous studies have shown tiger moths use ultrasound as a defense mechanism. However, tiger moths use a vibrating membrane on the thorax to produce the sound, while hawk moths emit the sound from their genitals.

Kawahara said the hawk moths may use the sound to warn others or to jam bats’ echolocation system, disrupting the predators’ ability to identify and hone in on an object.

“So much work has been focused on animals that are active during the day, but there are a lot of really interesting things happening at night, and we just don’t know a lot about what is actually going on – because we can’t hear or see it,” Kawahara said. “The fascinating part is that there are a lot of new discoveries to be made. It’s a totally unknown, unexplored system.”

Using high-energy lamps to capture the hawk moths in the jungle, the research team played pre-recorded bat sounds to the insects and captured the sounds the hawk moths made in response. They found at least three different hawk moth species produce the sound, including both males and females.

“As a museum, we are creating a library of life,” Kawahara said. “Museum specimens are usually preserved immediately, but we are trying to understand the behavior of these organisms so that we have a record of their behavior along with the specimen and DNA. This is why there are so many interesting things we’re starting to discover.”

In addition to providing more information about a particular species, echolocation research could also translate into improvements in ultrasound medical technology, the researchers suggested.

The team said they plan to continue researching the hawk moths’ ultrasound capabilities with an emphasis on determining the evolution of this defense mechanism.

“We think hawkmoths are a primary food source for bats because none appear to be chemically defended, which is why they have evolved anti-bat ultrasound strategies,” Kawahara said. “Hawkmoths have evolved different ways of avoiding bats – I can’t even explain how amazing the system is, it is just fascinating.”

With more than 1,400 species worldwide, hawk moths are some of the fastest and most proficient flying insects. They are also considered to be important pollinators, with many plants dependent solely on hawk moths for reproduction.

White Dwarf Study Shows Nature’s Constants May Not Be So Constant

Lee Rannals for redOrbit.com – Your Universe Online

An international team of astronomers wrote in the journal Physical Review Letters they were able to test a controversial theory about the constants of nature.

The team studied a distant white dwarf star using the Hubble Space Telescope to measure the strength of the electromagnetic force, or alpha, one of the four fundamental forces that shape the universe as we know it. The researchers hoped to determine whether the laws of physics were constant throughout the universe.

“This idea that the laws of physics are different in different places in the cosmos is a huge claim, and needs to be backed up with solid evidence,” said Dr Julian Berengut of the University of New South Wales’ School of Physics. “A white dwarf star was chosen for our study because it has been predicted that exotic, scalar energy fields could significantly alter alpha in places where gravity is very strong.”

Scaler fields are forms of energy that appear in theories of physics that seek to combine the Standard Model of particle physics with Einstein’s general theory of relativity.

“By measuring the value of alpha near the white dwarf and comparing it with its value here and now in the laboratory we can indirectly probe whether these alpha-changing scalar fields actually exist,” said Berengut.

The team studied the light absorbed by nickel and iron ions in the atmosphere of a white dwarf known as G191-B2B. The ions are kept above the surface by the star’s strong radiation, despite the pull of its extremely strong gravitational field.

“This absorption spectrum allows us to determine the value of alpha with high accuracy. We found that any difference between the value of alpha in the strong gravitational field of the white dwarf and its value on Earth must be smaller than one part in ten thousand,” Dr Berengut says. “This means any scalar fields present in the star’s atmosphere must only weakly affect the electromagnetic force.”

He said more precise measurements of iron and nickel on Earth would be needed in order to complement the high-precision astronomical data. “Then we should be able to measure any change in alpha down to one part per million. That would help determine whether alpha is a true constant of Nature, or not,” Berengut added.

Team member Professor Martin Barstow of the University of Leicester, who presented the work at the Royal Astronomical Society National Astronomy Meeting in St Andrews, Scotland said the team’s work was limited by the need to use very old laboratory measurements from the 1970s.

“In the future, with better laboratory data to complement the high-precision astronomical data, we should be able to measure the change in alpha down to one part per million. At that level we would be able to place strong restrictions on whether alpha is a true constant of nature,” Barstow said.

Across America 2013: Solar Impulse Prepares For Final Leg To New York

Lawrence LeBlond for redOrbit.com – Your Universe Online

The Solar Impulse team of Bertrand Piccard and Andre Borschberg are now preparing for the final flight of their HB-SIA zero-fuel airplane in the Across America 2013 campaign. Borschberg will take control of the solar-powered airplane for this final leg of the journey from Washington, DC to New York.

Borschberg is scheduled to take off from Washington Dulles International Airport on Saturday, July 6 at around 5:00 am EDT. The estimated landing time is 2:00 am at JFK International Airport on July 7. The NY landing will be the culmination of an epic journey that began in San Francisco, California on May 3.

The ambitious Across America 2013 journey was not only taken on to show off the capabilities of an airplane that can fly both day and night solely on the power of the sun’s energy, but also to inspire governments and the public to take a broader stance on clean technologies. During the Washington, DC layover, Secretary of Energy Ernest Moniz met with the Solar Impulse team. The highlights of the meeting were to emphasize how Solar Impulse aligns with four key DOE priorities: solar energy, energy storage, energy efficiency and advanced materials.

Along with the Across America 2013 campaign, Piccard and Borschberg promoted their Clean Generation initiative, offering specially designed flags at each of the key destinations throughout the mission. Clean Generation is also meant to inspire people to seek cleaner technologies and, to help promote the idea, all those who signed up for the initiative had a chance to ride in the Solar Impulse airplane as virtual passengers — their names being carried on a USB stick along with Piccard and Borshcberg during their flights.

The Solar Impulse team has also initiated a landing contest for New York City residents. The contest will allow 50 lucky persons the chance to greet the Solar Impulse team as it lands at JFK on the morning of July 7, completing the Across America 2013 project.

Google will also hold a live broadcast of the final flight on a dedicated Google page that will also include information about the final leg and the overall project, including links to Solar Impulse’s live broadcast and their YouTube channel.

A Google Hangout is also scheduled with the Solar Impulse pilots, moderated by Wired Mag’s Jason Paur. The Hangout will feature guests including Erik Lindbergh, the grandson of aviation pioneer Charles Lindbergh.

The Solar Impulse team is also encouraging citizens to go out during the final flight and see if they can spot the plane as it passes overhead along key landmarks, including the Statue of Liberty, scheduled at around 12:00 am, a few hours before touchdown at JFK. People can check out real-time location updates on the Solar Impulse webpage via their mobile devices and can even post pictures and videos on the group’s social media page.

Also, the Solar Impulse team will be carrying a special edition of the book ‘The Little Prince’ for the final leg of the journey. This is to help mark the 70th anniversary of the book’s publication in New York in 1943, which is linked to the history of aviation. The book is also being honored by the Antoine de Saint Exupery Youth Foundation.

Once the team lands in NY several events are scheduled to take place, including a press conference on Monday at noon at JFK, participation in the NASDAQ Opening Bell Ceremony and a meeting with UN Secretary General Ban Ki-Moon on Tuesday, July 9.

But before all this occurs, the zero-fuel airplane must complete the final leg of the Across America 2013 mission. While the flight has been confirmed, mission operators said the schedule could change depending on weather conditions.

Tentatively, the final flight is scheduled to begin at 5:00 am on July 6, with Borschberg taking off from Washington Dulles International Airport in Washington DC. The plane should cross Chesapeake Bay at around 6:45 am and head toward Cambridge in Maryland. The plane should fly across Delaware Bay at around 8:00 am, crossing into New Jersey and following the coast toward Atlantic City.

At around 9:15 am, Borschberg should be in the proximity of Atlantic City before flying 11 miles offshore for a long holding pattern until 9:00 pm, when he will then return toward land to complete the flight. He will enter the Lower Bay at around 11:40 pm, fly over the Verrazano Narrows Bridge and toward the Statue of Liberty around 12:00 am, and then on to Upper Bay, where he will hold until about 1:15 am.

Borschberg is expected to land the solar-powered aircraft at John F. Kennedy International Airport in New York at 2:00 am on July 7.

Image Below: An itinerary map of the entire Across America 2013 campaign. Credit: Solar Impulse

Mysterious Flashes Could Be Blitzars, Dying Neutron Stars

John P. Millis, PhD for redOrbit.com – Your Universe Online

Radio observatories have recently noticed bursts of radio light emerging in the night sky. The intense flashes exist for only a moment then disappear and do not seem to repeat.

These so called ‘blitzars’ are a mystery, but researchers Heino Falcke (Max-Plank Institute for radio astronomy) and Luciano Rezzolla (Albert-Einstein Institute in Potsdam) have suggested we may be witnessing the death-cry of a supermassive pulsar collapsing into a black hole.

Usually, solar cores greater than about two solar masses will immediately collapse into a black hole following a supernova event. However, in extreme cases that rapid rotation of the core can cause the process to stop at the neutron star phase, persisting for perhaps millions of years.

Eventually, the neutron star will slow due to the magnetic field interacting with the interstellar medium. Once the angular momentum is no longer able to sustain the neutron star, it will collapse under its own gravity into a black hole.

During this process the intense magnetic field of the neutron star would disintegrate, casting the energy of the field into the surrounding space. (While neutron stars have incredibly powerful magnetic fields, black holes are comparatively weak.) This “casting-off” of the magnetic field energy could manifest itself as a flash of radio light.

In theory, the location of the millisecond radio burst should be coincident with a young stellar mass black hole. However, it is speculated that these objects would lie in distant galaxies, perhaps beyond our current ability to confirm their existence. However, this would provide a means to trace the rate of core-collapse supernovae throughout the Universe.

A preprint of their theory paper, submitted to Astronomy & Astrophysics, can be found here.

Astronomers Catch Distant Galaxy Snacking On Gas

Lee Rannals for redOrbit.com – Your Universe Online
Astronomers were recently able to catch a distant galaxy in the act of snacking on nearby gas while using the European Southern Observatory’s (ESO) Very Large Telescope (VLT).
The team wrote in the journal Science about how they were able to make the best direct observational evidence so far supporting the theory that galaxies pull in and devour nearby material to grow and form stars. Scientists have always suspected galaxies grow this way, but until now, no one has directly observed this act.
Astronomers using VLT studied a very rare alignment between a distant galaxy and an even more distant quasar. The light from the quasar passed through the material around the foreground galaxy before reaching Earth, allowing the team to observe the galaxy and its surrounding gas in more detail.
“This kind of alignment is very rare and it has allowed us to make unique observations,” explained Nicolas Bouche of the Research Institute in Astrophysics and Planetology (IRAP) in Toulouse, France, lead author of the new paper. “We were able to use ESO’s Very Large Telescope to peer at both the galaxy itself and its surrounding gas. This meant we could attack an important problem in galaxy formation: how do galaxies grow and feed star formation?”
Like a car making a long road trip, galaxies quickly deplete their gas reservoirs as they create new stars. Astronomers assumed from this that galaxies replenished themselves by consuming surrounding gas using its own gravitational pull. As a galaxy drags gas inwards, the gas rotates around the galaxy before falling in. The new observation shows both how the galaxy was rotating and the composition and motion of the gas outside the galaxy.
“The properties of this vast volume of surrounding gas were exactly what we would expect to find if the cold gas was being pulled in by the galaxy,” said co-author Michael Murphy of Swinburne University of Technology in Melbourne, Australia in a recent statement. “The gas is moving as expected, there is about the expected amount and it also has the right composition to fit the models perfectly. It’s like feeding time for lions at the zoo — this particular galaxy has a voracious appetite, and we’ve discovered how it feeds itself to grow so quickly.”
Astronomers have discovered evidence of material around galaxies in the early Universe, but this is the first time they have been able to show clearly that the material is moving inwards rather than outwards.
“In this case we were lucky that the quasar happened to be in just the right place for its light to pass through the infalling gas. The next generation of extremely large telescopes will enable studies with multiple sightlines per galaxy and provide a much more complete view,” said co-author Crystal Martin of the University of California Santa Barbara.
Astronomers reported last October that our own galaxy is apparently slowly consuming the remnants of an ancient star cluster. A team from Yale University said they found the Milky Way was consuming this “light snack” in the southern Galactic sky region.

To Preserve Memory Into Old Age, Keep Your Brain Active!

Michael Harper for redOrbit.com – Your Universe Online

Good news for those reading and writing this article: a new study from Rush University Medical Center in Chicago claims reading and writing may preserve memory into old age. By keeping your brain active, says study author Robert S. Wilson, PhD, you’re able to slow the rate at which your memory decreases in later years.

This is not the first time researchers have arrived at such a conclusion, of course. Previous studies have also found keeping the brain active by reading, writing, completing crossword puzzles and more can essentially exercise the brain and keep it limber far into old age. One study also concluded that keeping television consumption to a minimal amount may also boost brain power over the years. Wilson’s study was recently published in the journal Neurology.

“Our study suggests that exercising your brain by taking part in activities such as these across a person’s lifetime, from childhood through old age, is important for brain health in old age,” said Wilson in a statement.

For his study, Wilson gathered nearly 300 people around the age of 80. He then gave them tests which were designed to measure both their memory and cognition each year until they passed away at an average age of 89. The same participants also answered questions about their past, such as whether they read books, did any writing, or engaged in any other mentally stimulating activities. The volunteers answered these questions for every part of their life, from childhood to adolescence, middle age and beyond.

When the participants passed away, their brains were then examined at an autopsy as Wilson’s team looked for physical evidence of dementia, such as lesions in the brain, tangles or plaques. After examining the brains of these volunteers and compiling the data from the questionnaires, Wilson’s team found those who had kept their minds active throughout their lives had a slower rate of memory decline than those who did not often participate in mentally challenging activities. Based on the amount of plaques and tangles in the brains, keeping your brain active is responsible for a 15 percent differential in memory decline.

The study also found the rate of memory decline was reduced by 32 percent in people who kept their brains active late in life. Those who were not mentally active had it much worse; their memories declined 48 percent faster than their actively reading and writing peers.

“Based on this, we shouldn’t underestimate the effects of everyday activities, such as reading and writing, on our children, ourselves and our parents or grandparents,” said Wilson.

And this news is hardly surprising. Doctors, teachers and parents have been admonishing children to turn off the television and pick up a book for years. There is no shortage of studies to back up their claims. A 2009 study, for example, found people who keep their brains active saw a 30 to 50 percent decrease in risk of developing memory loss. This study, conducted by doctors at the Mayo Clinic in Rochester, Minnesota observed people between the ages of 70 and 89 with and without diagnosed memory loss.

Those who were likely to read magazines or engage in other social activities were 40 percent less likely to develop memory loss than homebodies who did not read. Furthermore, those who spent less than seven hours a day watching television were 50 percent less likely to develop memory loss than those who planted themselves in front of the tube for long stretches of time.