Connie K. Ho for redOrbit.com — Your Universe Online
Researchers at Oregon State University (OSU) recently conducted a comprehensive review and discovered that higher-dose use of particular statins can help treat high cholesterol and other blood lipid problems.
In particular, the researchers believe that medications should be considered as an option after patients have tried to manage cholesterol issues with changes in diet and exercise. According to the review´s findings, some statins are more effective than others. As well, statins combined with lipid-lowering medications may not always work better. The review was featured in the Annals of Pharmacotherapy and included results on the various treatment options for overly high LDL cholesterol levels, too low HDL cholesterol levels, as well as increased levels of triglycerides.
“Statins are proven medications that can reduce heart attacks and strokes by about 30 percent in the patients that need them,” explained the study´s author Matt Ito, a professor of pharmacy practice at OSU and president-elect of the National Lipid Association, in a prepared statement.
The study highlighted how statin drugs can help lower LDL, otherwise known as “bad,” cholesterol for moderate and high risk patients who have problems managing their cholesterol levels or who have suffered a heart attack or angina as side effects of cardiovascular disease. As well, in some cases, increasing the amount of statin was found to be a protective measure against cardiovascular issues and was more effective than other drugs or a mix of other drugs.
“What we looked at here was whether adding other drugs or therapies to the use of statins could further reduce problems, and in most cases the research indicates that they didn´t help,” continued Ito in the statement. “What did help was increasing the statin dose to higher levels within the range for which they are approved. And there did not appear to be a significant change in side effects based on any approved dosage.”
The group of investigators looked at “intensive monotherapy,” where high dosages of only one statin drug are utilized to lower LDL cholesterol to 100 mg/dL or less or 70 mg/dL or less for patients who have already had special risks like coronary disease or diabetes. The findings of the study showed that an average patient who undergoes intensive monotherapy could only be prescribed the drugs atorvastatin (brand name Lipitor) and rosuvastatin (brand name Crestor), which have both been used to decrease the amount of cholesterol in the blood of adults. Even though statin drugs are mainly well tolerated by patients, there may be some side effects such as muscle pain or damage. Medical experts state that it is important to consider these kinds of side effects when creating safe dosages for individuals.
“The reaction to statin regimens varies with the individual, so some of these other drugs may also be able to accomplish the goals we´re seeking,” noted Ito in the statement. “These recommendations are based on results with an average patient, but physicians may find some of their patients can do adequately well with other statins, or that they don´t need intensive monotherapy.”
For patients who are concerned about their cholesterol levels, the Foundation of the National Lipid Association provides important information for individuals. The organization provides a number of tricks and tips for lifestyle management. For one, they recommend that people consume a diet full of dietary fiber, lean sources of protein, and healthier fats and oils like liquid vegetable oils. They also advise that individuals eat less foods that are rich in saturated fat, avoid foods that have “partially hydrogenated” oil or trans fat, and limit intake of sweets and sugary beverages.
Big Blue Eyeball Found On Florida Beach Belongs To Swordfish
Lawrence LeBlond for redOrbit.com – Your Universe Online
A huge eyeball found on a Florida beach last week by a local resident is believed to be from a swordfish, according to the state Fish and Wildlife Conservation Commission (FWC).
On Monday, FWC experts said based on the color of the eye, its size and structure, and along with the presence of bone around it, the animal most-likely associated with it was the large, predatory sport fish. The FWC said DNA testing is currently underway to confirm the finding.
Early speculation from officials, as well as Gino Covacci, who found the peculiar peeper, was that the eyeball was from a giant squid. But after examinations, experts said the eyeball didn´t quite fit the squid profile, according to a statement by Joe Herrera, a curator with FWC´s Fish and Wildlife Research Institute in St. Petersburg, Florida.
Herrera said because of the straight cuts on the bone around the eyeball, experts believe an angler cut it out of a swordfish and tossed it overboard. It also fits for the location, he noted, as swordfish are frequently found in the Florida Straits off South Florida this time of year, near where the eyeball turned up on Pompano Beach.
The FWC´s initial finding mirrors that of Charles Messing, a professor at Nova Southeastern University´s Oceanographic Center, who told Florida’s Sun Sentinel newspaper on Friday he believed, based on images of various sea creatures, that the eyeball belonged to a swordfish.
Study On The Biggest Loser Shows Long-Term Effect Of Diet and Exercise
Connie K. Ho for redOrbit.com — Your Universe Online
The holidays are coming up, and it can be a dangerous trap for those trying to lose weight. However, researchers have found that while diet is an important factor, exercise plays an important role as well. A new study by the National Institute of Diabetes and Digestive Kidney Disease (NIDDK) recently revealed that modest diet and exercise could help decrease body fat and sustain muscle in adults.
The study, conducted under the National Institutes of Health, was recently featured in the online edition of Obesity. The findings showcased that both diet and exercise play a role in weight loss, as opposed to only diet alone. Researchers looked at data from 11 participants of “The Biggest Loser,” a reality television show on the National Broadcasting Company (NBC) that showcases obese adults who lose weight over a number of months. The scientists specifically studied the impact of a restricted diet and strenuous exercise regime.
“By including the show’s contestants as voluntary study participants, this research took advantage of a cost-efficient opportunity to study a small group of obese individuals already engaged in an intensive lifestyle intervention,” remarked NIDDK senior investigator Kevin Hall, who is unaffiliated with the television program, in a prepared statement.
In the project, the researchers found the body fat, resting metabolic rate (amount of energy that was used during periods of inactivity), and total energy expenditure of participants at the start of the program, during the third week, and at week 30. Week 30 was also the week in which participants returned home after training at an isolated ranch for 17 weeks. The average weight loss in the program was 128 pounds, with approximately 82 percent pounds lost due to reduction of body fat and the other 98 percent based off the preservation of lean tissue. The researchers believe that the preservation of lean tissue brought a number of benefits to the individuals, including maintaining strength and mobility while also lowering the risk of injury.
To calculate the changes in diet and exercise along with the weight loss, the scientists utilized a mathematical computer model that focused on the differences in human metabolism. The computer model looked at the results due to specifically diet and exercise as opposed to other factors that may have been involved. Through an exercise simulation, they determined that participants who adapted moderate lifestyle changes could keep their weight loss and prevent weight gain; these small changes included activities like participating in 20 minutes of daily intense exercise or decreasing calories by 20 percent .
“This study reinforces the need for a healthy diet and exercise in our daily lives,” remarked Dr. Griffin P. Rodgers, NIDDK Director, in the statement. “It also illustrates how the science of metabolism and mathematical modeling can be used to develop sound recommendations for sustainable weight loss – an important tool in the treatment of obesity – based on an individual´s unique circumstances.”
The research comes at the right time. According to the NIH, over two-thirds of U.S. adults who are 20 years and older are overweight or obese. As well, over one-third of adults are considered obese. Individuals who are considered obese have a greater risk for heart disease, high blood pressure, stroke, type 2 diabetes, and certain forms of cancer.
Fungal Meningitis Reported In 15 States, 214 Cases Reported, 15 Deaths
Lawrence LeBlond for redOrbit.com – Your Universe Online
A fungal meningitis outbreak linked to contaminated steroid injections has now been expanded to 15 states after Pennsylvania reported the first case on Monday, according to a Reuters report.
At least nine new infections have been linked to the contaminated drug made by the same pharmaceutical responsible for 15 deaths and 205 previous cases of fungal meningitis, now expanding the list to 214. Of the new reported cases, two were heart transplant patients who were administered cardioplegic solution produced by the New England Compounding Center (NECC) in Framingham, Massachusetts during surgery, officials with the Food and Drug Administration (FDA) said in a statement.
A third infection occurred in a Pennsylvania patient who had received an epidural steroid injection in July from medications supplied by NECC. That person is being treated in a hospital, the Pennsylvania Department of Health said.
NECC had shipped more than 17,000 doses of the injectable steroid methylprednisolone acetate to 76 facilities in 23 states; Some 14,000 doses have been reportedly used. Some of those sickened by the contaminated injection have been hospitalized and are seriously ill.
Over the weekend the US Centers for Disease Control and Prevention (CDC) said 205 people had been stricken by the infection so far, with Illinois and New Hampshire also reporting their first cases.
Triamcinolone acetonide, an injectable steroid product also made by NECC, has also been identified as contaminated and had been reported to the FDA. The Pennsylvania case has been tied to this drug. Up until this point, all previous “cases of meningitis“¦have been associated with methylprednisolone acetate,” said officials with the regulator.
The FDA has yet to confirm the latest infections were caused by the NECC product.
“Investigation of these patients is ongoing; and there may be other explanations for their Aspergillus infection. Cardioplegic solution is used to induce cardiac muscle paralysis during open heart surgery to prevent injury to the heart,” the FDA said.
“The sterility of any injectable drug, including ophthalmic — eye — drugs that are injectable or used in conjunction with eye surgery, and cardioplegic solutions produced by the New England Compounding Center are of significant concern, and out of an abundance of caution, patients who received these products should be alerted to the potential risk of infection,” the regulator added.
At this time, no cases of infection have been linked to the ophthalmic drug produced by NECC, but the FDA is continuing to monitor the situation, noting that this class of products could potentially pose similar risks of infection.
The outbreak has caught the attention of President Barack Obama, who has noted his concern about the severity of illnesses. Jay Carney, a White House spokesperson told UPI reporters the president had been briefed on the situation and was “as concerned about it as you would expect given the severity of the impact on some people who have either died or gotten very sick.”
The CDC on its website said it is currently not recommending “empiric anti-fungal therapy for symptomatic patients who have normal cerebrospinal fluid laboratory examination. These patients should be closely monitored and re-evaluated for progression of symptoms“¦Should the patient have progression of symptoms, a lumbar puncture — a spinal tap in which a thin needle draws fluid surrounding the spinal cord and the brain — should be repeated immediately, using a different site than was used for the epidural — lower back — injection when possible.”
However, the CDC has listed a series of recommendations for physicians treating patients who were administered the steroid based on growing evidence that Exserohilum rostratum–a brown-black mold, or fungus–was the predominant pathogen in this outbreak. Also, expert opinion and published literature indicated the drug voriconazole might be effective in treating infections due to brown-black molds as well as infections due to the Aspergillus species.
The CDC said it is continuing consultations with health experts on treatment options for patients associated with this series of illnesses. The CDC is also recommending physicians of patients with fungal meningitis symptoms or infections should consult infectious disease experts for assistance.
Dr. J. Todd Weber of the CDC said treating the patients sickened by the contaminated steroid is “new territory” because it has never caused meningitis before.
“We have been working directly with the clinics to ensure that patients who received these injections are monitored and receive any necessary follow-up,” said Acting Pennsylvania Secretary of Health Michael Wolf.
Currently, Tennessee has seen the worst outbreak of the infection with 53 cases and six deaths. The state government suspended NECC´s license on Monday; NECC had already surrendered its license in Massachusetts, has halted operations and has recalled all of its products. Its sister company, Ameridose, has also suspended its operations.
A list of the NECC recalled products may be found on the FDA´s website.
NECC is facing a barrage of federal and state investigations. The outbreak has raised concerns about how the pharmaceutical industry operates, especially as NECC engaged in the little-known practice of drug compounding that is not regulated by the FDA.
In drug compounding, pharmacies prepare specific doses of approved medications, based on guidance from a doctor, to meet an individual patient’s need.
An investigation by Reuters found that one NECC customer received solicitations from NECC for bulk orders and failed to require proof of individual patient prescriptions as required by state regulation. After failure to only deliver products in response to patient-specific prescriptions in Massachusetts was realized, the company forfeited its license there.
Several states are following the FDA and launching their own probes against the company, including Michigan, Massachusetts, Indiana, Montana and Ohio.
“We continue to cooperate with the FDA, as we are with the CDC and the Board of Registration in Pharmacy of the Massachusetts Department of Public Health,” said the NECC in a statement, adding that it was reviewing all information garnered by the regulator.
In Tennessee, where the most cases have occurred, 71-year-old Janet Russell was the first person to file a lawsuit against NECC seeking $15 million in damages after being diagnosed with meningitis. Russell claimed she contracted the infection after receiving an injection of methylprednisolone for back pain on August 30 at St. Thomas’ Outpatient Neurosurgery Center.
Her lawsuit states that as a result, she is suffering constant pain, the effects of a stroke, permanent disability, and emotional distress and will need ongoing treatment due to the infection. Russell is currently in the hospital’s intensive care unit, her attorney said.
U.S. Senator Richard Blumenthal of Connecticut called for an immediate criminal investigation of NECC and its officers and employees. “The scope of this disaster, which only increases by the day, is a call to action for increased federal oversight of these unauthorized drug manufacturers masquerading as compounding pharmacies,” he said in a statement.
The states that have so far reported cases of fungal meningitis include: Tennessee, Michigan, Pennsylvania, New Hampshire, Illinois, Indiana, Minnesota, New Jersey, Texas, Idaho, Maryland, North Carolina, Virginia, Ohio and Florida.
Remove Displaced Objects In Child’s Nose With Mother’s Kiss
Connie K. Ho for redOrbit.com — Your Universe Online
Researchers recently discovered that “mother´s kiss,” a technique to take out foreign objects stuck in kid´s nasal passages, is an effective method that limits the need for more invasive procedures like hooks or forceps.
There are a number of objects that can become lodged in a child´s nasal passageway. Some of objects may include items like beads, crayons, cotton, erasers, food, dried beans, seeds, small toys, and paper wads. Symptoms can include problems breathing, nasal discharge, as well as irritation or pain in the nose. The findings on the effectiveness of the “mother´s kiss” were recently published in the Canadian Medical Association Journal (CMAJ).
“The mother’s kiss appears to be a safe and effective technique for first-line treatment in the removal of a foreign body from the nasal cavity,” commented Dr. Stephanie Cook of the Buxted Medical Centre in the United Kingdom in a prepared statement. “In addition, it may prevent the need for general anesthesia in some cases.”
With this method, the mother of the child or a relative utilizes his or her mouth to cover the mouth of the child. The person also blocks the nostril with a finger and blows into the mouth, which creates a cover. The breath from the mouth then acts as a suction to remove the foreign object. Based on the study, the researchers recommend that the parent or relative first explain to the child the technique so that he or she is not afraid. It can also be done with the help of a medical expert and repeated however many times until the object is removed.
“[Mother´s kiss] can work,” Dr. Nina Shapiro of Mattel Children´s Hospital of the University of California, Los Angeles told WebMD. “It is more important that there were no adverse events such as bleeding or pushing the object further up the nostril.” According to the findings of this study, “the worst thing that can happen is that it doesn’t work.”
According to U.S. News, the team of investigators looked at eight case studies and concluded that the technique was useful for youths between the ages of one and eight years of age.
“Children feel comfortable and are not threatened with this removal technique that we commonly utilize in the emergency department,” remarked Dr. Robert Glatter in the WebMD article.
The scientists recommend that parents and guardians first discuss with their pediatricians on the “mother´s kiss” for any special instructions.
“The mom has to be brave,” continued Glatter in the WebMD article. “Some parents want to try it and others are scared of it.”
They team of investigators believe that further studies need to be done to analyze the different positive-pressure techniques and to identify the effectiveness in various situations, depending on the object or the duration that the object is caught in the nasal passages.
The U.S. National Library of Medicine under the National Institutes of Health also offers helpful information for parents who may find that their children have foreign objects in the nasal passage. Medical experts recommend that items should not be removed with tweezers or other tools. To prevent items from becoming stuck in a child´s nasal passages, it is best to keep small objects away from infants and toddlers as well as to prevent children from placing objects in various body openings.
Researchers Find New Way To Make Materials Iridescent And Ultra Water Proof
Jedidiah Becker for redOrbit.com — Your Universe Online
Read my exclusive interview with Professor Shu Yang about her research.
Have you ever looked at a peacock´s feathers, a butterfly´s wing or an oily puddle on the road and wondered why they have those shimmering, vibrant colors?
Unlike the colors you see in spring grass, an animals´ fur or fading autumn leaves, these iridescent hues are not the result of pigmentation but rather of a naturally occurring phenomenon known as “structural color.” And while the royal azure of the male peacock´s feather may resemble the deep indigo of a ripe blueberry, the mechanisms that produce these colors are fundamentally different at the most basic level.
According to a study published in the journal Advanced Functional Materials, a team of researchers from the University of Pennsylvania has found a new way to artificially recreate structural colors in a laboratory while also combining them with another highly useful physical property: the ability to strongly repel water known as “superhydrophobicity.”
“A lot of research over the last 10 years has gone into trying to create structural colors like those found in nature, in things like butterfly wings and opals,” says Shu Yang, the team´s lead researcher. Yang is an associate professor at the university´s Department of Materials Science and Engineering and a leading expert in the fields of biomaterials, polymers and nanostructured materials.
Yang also says that a lot of research has been devoted in recent years to creating materials that exhibit superhydrophobicity, a characteristic which could have innumerable applications in both the industrial and domestic spheres. However, Yang´s research team has used a bit of outside-the-box thinking to become one of the few laboratories to successfully create a material that combines the properties of structural colors as well as those of superhydrophobicity.
THE SCIENCE OF STRUCTURAL COLORS & SUPERHYDROPHOBICITY
The mechanisms that produce both structural colors and superhydrophobicity rely on the basic physical structure or geometry of a material rather than on its chemical properties.
To understand how structural colors work and what makes them so unique, it helps to first remember how pigments — a more familiar form of coloration — work.
At the molecular level, when light strikes a pigment, certain wavelengths of light are absorbed by the pigment´s electrons while other waves are simply reflected. Thus the colors that the human eye perceives are actually those wavelengths of light that weren´t absorbed by the pigment. When you look at a bowl of ripe blueberries or the petals of a violet, you´re essentially seeing the spectrum of light that was ℠rejected´ by a natural pigment called anthocyanin.
In contrast to pigments, structural colors are the result of light interacting with tiny repeating patterns and structures on the surface of a material. As with pigments, these “microstructures” or “nanostructures” correspond with different wavelengths of light.
Unlike pigments, however, these microstructures don´t create color by absorbing light of certain wavelengths. Instead, they interact and interfere with the path of the light rays, subjecting them to a variety of optical phenomena such as thin film interference, diffraction grating effects, multilayer interference, photonic crystal effects, and light scattering.
In turn, these different types of optical phenomena cause light of particular wavelengths to be reflected through constructive and destructive interference which can intensify the color or give it that shimmery, iridescent quality.
And since structural colors depend entirely on the arrangement of molecules on the nanoscale rather than on electronic absorption at the chemical level, a peacock feather or butterfly wing that is ground into a fine powder will not retain its color since the grinding process destroys these nanostructures.
Like structural colors, a superhydrophobic surface — one that is extremely hard to make wet — also depends on the basic microstructure of the material. However, it relies on the roughness of a material at the nanoscale. Since water adheres best to flat surfaces where it can maximize contact area, “rough” surfaces make it difficult for water get “grip” and are thus water repellant.
A LITTLE LAB MAGIC
In attempts to create structurally colored surfaces that are also ultra water repellant, researchers have experimented with a variety of methods that involve different combinations of complex, intricate steps. These attempts have typically involved first creating the colored surface using 3D polymers. Once this basic foundation is laid which creates the structural color, they then use different techniques to attempt to “roughen” the surface and make it water repellant without damaging the delicate nanostructures that gives the surface its optical properties.
Yang´s team, however, decided to take a creative new approach for creating both of the desired properties.
First, they began with a technique known as holographic lithography which uses a laser to create a three-dimensional network of lattices on a synthetic material called photoresist. Those parts of the photoresist not exposed to the laser beam were then removed by washing the material in a solvent. This left “holes” in the unlasered areas which, in turn, gave the material the surface properties needed to produce its structural color.
Then it was time to make the material super water repellant. Whereas most previous processes have used techniques known as nanoparticle assembling or plasma etching to create the desired roughness, Yang´s team was able was able to make the material´s surface rough by simply using a different solvent after the photoresist was removed.
Yang explained that the secret was to use a poor solvent after the photoresist had been washed off. While good solvents try to maximize their contact with the material´s surface, poor solvents produce the exact opposite effect — a property that the researchers were able harness.
“The good solvent causes the structure to swell,” explained Yang.
“Once it has swollen, we put in the poor solvent. Because the polymer hates the poor solvent, it crunches in and shrivels, forming nanospheres within the 3D lattice.”
The tiny nanospheres created by the poor solvent give the surface the roughness it needs to become superhydrophobic without disturbing the network of lattices that produce it´s structural color.
“We found that the worse the solvent we used, the more rough we could make the structures,” Yang said.
APPLICATIONS
One of the most urgent forces propelling the research and development of superhydrophobic materials is their potential to reduce energy consumption. Because all kinds of optical devices — from LCD´s to solar panels — rely on the efficient transmission of light through transparent surfaces, the ability to apply a water-repellent, self-cleaning coating to these surfaces could have a tremendous impact on the energy efficiency of countless electronic devices
Yet while both researchers and industry leaders see a wide variety of practical applications for materials that exhibit both superhydrophobicity and structural color, Yang´s team has also embraced vision for this combination of properties that is at once aesthetic and pragmatic.
“Specifically, we´re interested in putting this kind of material on the outside of buildings. The structural color we can produce is bright and highly decorative, and it won´t fade away like conventional pigmentation color dies. The introduction of nano-roughness will offer additional benefits, such as energy efficiency and environmental friendliness.”
“It could be a high-end facade for the aesthetics alone, in addition to the appeal of its self-cleaning properties. We are also developing energy efficient building skins that will integrate such materials in optical sensors.”
Yang´s research was supported by the Office of Naval Research and the National Science Foundation.
Apple Sued Over Eye On MacBook Pro Retina Display
Michael Harper for redOrbit.com – Your Universe Online
Apple likes to choose some stunning images whenever they announce and/or show off their Retina displays. For instance, we´ve seen images of peacock feathers, roaming zebras, and even brightly colored hot air balloons, including screen grabs from the popular Pixar movie “UP.” However, when Apple released their impressive new 15-inch MacBook Pro with Retina Display (the largest Retina display yet) they may have gotten themselves in a bit of legal trouble. According to Patently Apple, whenever Apple first showed off this new, larger Retina Display, they began using an image they did not have permission to use.
Sabine Liewald of Switzerland says Apple used her picture of a woman´s eye, dressed in colorful blue, green and yellow makeup, to market the MacBook Pro display. Now, Liewald is suing Apple for using this image without her permission.
As the story goes, Apple contacted Liewald´s agency, Factory Downtown, to obtain a high-resolution image of the file. At the time, the MacBook maker had said they only wanted to use the image for “comping” or layout purposes and had no intent to use it in marketing. According to Liewald, Apple knew at all times they did not have permission to use this image in their advertisements.
Obviously, Apple did use the image in their marketing for the new Retina displays, and now Liewald is seeking restitution.
The artist has filed a suit in the United States District Court for New York Southern District, Judge Jesse M. Furman presiding.
Liewald is also looking for more than damages in the suit, however. According to Cult of Mac, she´s also “going for the throat” and looking for a piece of Apple´s profits as well.
While the damages claim is realistic, seeking profits may be a bit of stretch in this case. Of course, Apple is the Most Valuable Company in the World, so it makes sense to swing for the fences when you have the opportunity.
Apple has since removed the offending image from their MacBook Pro with Retina display website, replacing it with another image of an eye, this time a left eye with more red makeup than blue.
This is the second run-in Apple has had with paying for Swiss intellectual property lately. When iOS 6 first rolled out last month, the Swiss Federal Railway took immediate notice of the new iPad clock app, saying it looked almost identical to their iconic clock-face which had been designed by Hans Hilfiker. This design had been both trademarked and copyrighted by the Swiss Federal Railway, who sent a little note to Apple alerting them to this misstep. Not long after, Apple decided to pay for the use of the image, striking a licensing deal with the Swiss Railway Service. The terms of the deal are unknown.
Apiology
Apiology is the scientific study of honey bees, a subdiscipline of melittology (the study of all bees), which is a subdiscipline of entomology. Melittology comprises of more than 17,000 species other than the honey bee. Apiology includes apicology, which is the study of honey bee ecology. Honey bees are often chosen as a study group to answer questions on the evolution of social systems.
People who study honey bees are called apiologists. There have been a number of notable apiologists throughout history.
Perhaps the most notable of apiologists would be Charles Butler (1560-1647), often referred to as the Father of English Beekeeping. Butler observed with his bees that these honey makers produce wax combs from scales of wax produced in their own bodies; and he was among the first to assert that drones are male and the queen female, though he believed worker bees lay eggs.
Other notable apiologists include Johann Dzierzon (1811-1906), who discovered parthenogenesis among bees; Karl von Frisch (1886-1982), a Nobel Prize winner who studied honey bee communication; L.L. Langstroth (1810-1895), who modernized American beekeeping; Amos Ives Root (1839-1923), an innovator in honey harvesting techniques, who also published the first account of the Wright brothers flight in his beekeeping journal; Stephen Taber III (1924-2008), an innovator in the practice of artificial insemination of queen bees for the purpose of developing disease resistant and gentle bee colonies; and Mark Winston, who currently studies life history, caste structure, and reproduction in social insects and pheromones of honey bees at Simon Fraser University in California.
Image Caption: A bee drinking water. From the apiary of Mr. Stanisław Kosiorek (Poland). Credit: Bartosz Kosiorek/Wikipedia (CC BY-SA 3.0)
Primates In Peril Report Highlights 25 Most Endangered Primates
Brett Smith for redOrbit.com – Your Universe Online
Madagascar´s isolation has led to the island developing some of the most unique plants and animals – so much so that many ecologists refer to it as the “eighth continent.”
Unfortunately, a report titled “Primates in Peril” from the International Union for Conservation of Nature (IUCN) has singled-out Madagascar as home to six of the twenty-five most severely threatened primate species living on the island located just off the eastern coast of Africa.
According to the report, these threatened monkeys, lemurs and gorillas are suffering from deforestation, loss of habitat, poaching and illegal trafficking.
“This report shows that the world’s primates are under increasing threat from human activities,” said Christoph Schwitzer, head of research at the Bristol Conservation and Science Foundation (BCSF) who was involved in the study.
“Whilst we haven’t lost any primate species yet during this century, some of them are in very dire straits,” he added.
One of the worst situations detailed in the report was that of the Madagascar’s rarest lemur, the northern sportive lemur (Lepilemur septentrionalis). Also known as the northern weasel lemur, only 19 individuals are left in the wild, according to the report.
“The lemurs are now one of the world’s most endangered groups of mammals, after more than three years of political crisis and a lack of effective enforcement in their home country, Madagascar,” explained Schwitzer.
In 2009, the government was overthrown by coup d´Ã©tat and conservation standards fell during the ensuing chaos. The U.S. government has denounced the current government´s ability to protect endangered species, including the rare lemurs.
According to Schwitzer, political upheaval and instability which affects and threatens species is not exclusive to the island nation.
“A similar crisis is happening in Southeast Asia, where trade in wildlife is bringing many primates very close to extinction,” Schwitzer said.
The report also noted the impending threat facing the pygmy tarsier (Tarsius pumilus) of Indonesia, a four-inch long primate that typically weighs around 2 ounces. This tiny primate was only seen in museums until 2008 when three were captured and one individual was seen in the wild.
The IUCN report was not without good news as Russell Mittermeier, a chairman at the IUCN, noted that biodiversity is in a constant state of flux.
“Amazingly, we continue to discover new species every year since 2000,” Mittermeier said. “What is more, primates are increasingly becoming a major ecotourism attraction, and primate-watching is growing in interest.”
Many biodiversity experts say some conservation efforts are beginning to pay dividends, with several primates being removed from endangered lists. Two such primates were India’s lion-tailed macaque and Madagascar’s greater bamboo lemur after they were targeted for conservation efforts and appeared to have recovered.
To combat the local threats to biodiversity, Madagascar has set up five nature reserves, 21 wildlife reserves, and 21 national parks. The international community has also rallied around the preservation of biodiversity in Madagascar with six of the national parks declared a joint World Heritage Site in 2007. They are the: Marojejy, Masoala, Ranomafana, Zahamena, Andohahela and Andringitra parks.
HPV Vaccinations Not Associated With Increased Sexual Activity In Adolescent Girls
Lawrence LeBlond for redOrbit.com – Your Universe Online
Despite previous warnings that adolescent girls who receive vaccines for human papillomavirus (HPV) would be more sexually active, a new study has found those concerns to be grossly unwarranted.
The new study, conducted by Robert Bednarczyk PhD, of Kaiser Permanente Center for Health Research-Southeast in Atlanta, and his colleagues, have found there is no difference in the sexual behaviors of adolescent girls who have received the HPV vaccine and their peers who have not been given the shot.
The vaccine, given to ultimately prevent cervical cancer, was believed by some opponents to encourage young girls to become more sexually active or to engage in riskier sex than they otherwise would without the shot. But this is not the case, according to the study, published online today in the journal Pediatrics.
For the study, researchers didn´t ask girls about having sex, but instead looked at “markers” of sexual activity after HPV vaccination. Specifically, they examined up to three years of records on whether girls had sought birth control advice; tests for sexually transmitted diseases or pregnancy; or had become pregnant.
The HPV shot has been recommended by the US Centers for Disease Control and Prevention (CDC) since 2006 for girls beginning at age 11. HPV is transmitted through sexual activity and causes genital warts and can lead to cervical, penile, vaginal, and head and neck cancers. The vaccine is also recommended for older girls who did not receive the vaccine when they were younger, and also for males at age 11 and older.
Despite recommendations, the vaccine has been slow to catch on. In the 5 years since becoming available to adolescent girls, only half have received even one dose of Gardasil. Since its introduction, the vaccine has been associated with increased sexual activity in teens. However, the Kaiser study, with a partnership from Emory University, of which Bednarczyk is also a member, has shown there is little evidence to warrant these claims.
“Our study found a very similar rate of testing, diagnosis and counseling among girls who received the vaccine and girls who did not,” said Bednarczyk. “We saw no increase in pregnancies, sexually transmitted infections or birth control counseling — all of which suggest the HPV vaccine does not have an impact on increased sexual activity.”
“This is reassuring news for teenagers, parents, and members of the public. Our study adds to growing evidence that the HPV vaccine is a safe and effective way to prevent these rare but sometimes deadly cancers,” added Robert Davis, MD, MPH, a co-author and senior investigator with Kaiser.
The study included nearly 1,400 eleven-year-old girls who were members of the Kaiser Permanente health plan in Georgia in 2006 and 2007 during the first 18 months after Gardasil became available. Of the group, 493 girls received at least one dose of the vaccine during the study period. A comparison group including 905 girls did not receive Gardasil, but did receive other recommended vaccines.
The researchers followed both groups for up to three years to assess whether they had been tested for or diagnosed with a sexually transmitted infection (STI), had taken a pregnancy test, or had been counseled about contraceptives.
Bednarczyk and colleagues found that about 10 percent of the girls in the study (counting those from both groups) had one or more of these outcomes. Only eight of the girls (less than 1 percent) were diagnosed with an STI or had a positive pregnancy test. And girls who received Gardasil did not have a substantially higher rate of testing, diagnosis, or counseling compared to those who did not receive the vaccine.
Some parents have been concerned that the vaccine was “a license to have sex,” but this latest study strengthens the evidence against that concern, Dr. Elizabeth Alderman, an adolescent medicine specialist at The Children’s Hospital at Montefiore in New York City who was not involved in the study, told CBS News.
A CDC study published in January suggested that the vaccine didn´t promote sexual activity among older girls, but it relied on self-reporting of girls from ages 15 to 24, Alderman noted, adding that self-reporting is notoriously unreliable.
Saad Omer, an infectious diseases and vaccine researcher from Emory University in Atlanta who worked on the study, told Genevra Pittman of Reuters Health: “Parents can be reassured at least based on the evidence that young girls who receive HPV vaccines did not show increased signs (of) clinical outcomes of sexual activity.”
Alderman has been a paid speaker for Merck & Co., which makes one of the two vaccines for HPV sold in the US, but stated she has no current financial ties to the company. Three of the study’s four co-authors have also reported they have done previous research funded by Merck.
“The administrative data used for this study did not provide an opportunity to do a detailed examination of the reasons for this counseling or of the extent of hormonal contraceptive use among girls in this cohort,” wrote the authors.
Ultrathin Coatings Change Color With Only A Few Atoms’ Difference In Thickness
In Harvard’s Pierce Hall, the surface of a small germanium-coated gold sheet shines vividly in crimson. A centimeter to the right, where the same metallic coating is literally only about 20 atoms thicker, the surface is a dark blue, almost black. The colors form the logo of the Harvard School of Engineering and Applied Sciences (SEAS), where researchers have demonstrated a new way to customize the color of metal surfaces by exploiting a completely overlooked optical phenomenon.
For centuries it was thought that thin-film interference effects, such as those that cause oily pavements to reflect a rainbow of swirling colors, could not occur in opaque materials. Harvard physicists have now discovered that even very “lossy” thin films, if atomically thin, can be tailored to reflect a particular range of dramatic and vivid colors.
Published in the journal Nature Materials (online) on October 14, the finding opens up new possibilities for sophisticated optical devices, as well as consumer products such as jewelry and new techniques in the visual arts.
The discovery is the latest to emerge from the laboratory of Federico Capasso, Robert L. Wallace Professor of Applied Physics and Vinton Hayes Senior Research Fellow in Electrical Engineering at SEAS, whose research group most recently produced ultrathin flat lenses and needle light beams that skim the surface of metals. The common thread in Capasso’s recent work is the manipulation of light at the interface of materials that are engineered at the nano- scale, a field referred to as nanophotonics. Graduate student and lead author Mikhail A. Kats carried that theme into the realm of color.
“In my group, we frequently reexamine old phenomena, where you think everything’s already known,” Capasso says. “If you have perceptive eyes, as many of my students do, you can discover exciting things that have been overlooked. In this particular case there was almost a bias among engineers that if you’re using interference, the waves have to bounce many times, so the material had better be transparent. What Mikhail’s done–and it’s admittedly simple to calculate–is to show that if you use a light-absorbing film like germanium, much thinner than the wavelength of light, then you can still see large interference effects.”
The result is a structure made of only two elements, gold and germanium (or many other possible pairings), that shines in whatever color one chooses.
“We are all familiar with the phenomenon that you see when there’s a thin film of gasoline on the road on a wet day, and you see all these different colors,” explains Capasso.
Those colors appear because the crests and troughs in the light waves interfere with each other as they pass through the oil into the water below and reflect back up into the air. Some colors (wavelengths) get a boost in brightness (amplitude), while other colors are lost.
That’s essentially the same effect that Capasso and Kats are exploiting, with coauthors Romain Blanchard and Patrice Genevet. The absorbing germanium coating traps certain colors of light while flipping the phase of others so that the crests and troughs of the waves line up closely and reflect one pure, vivid color.
“Instead of trying to minimize optical losses, we use them as an integral part of the design of thin-film coatings,” notes Kats. “In our design, reflection and absorption cooperate to give the maximum effect.”
Most astonishingly, though, a difference of only a few atoms’ thickness across the coating is sufficient to produce the dramatic color shifts. The germanium film is applied through standard manufacturing techniques–lithography and physical vapor deposition, which the researchers compare to stenciling and spray-painting–so with only a minimal amount of material (a thickness between 5 and 20 nanometers), elaborate colored designs can easily be patterned onto any surface, large or small.
“Just by changing the thickness of that film by about 15 atoms, you can change the color,” says Capasso. “It’s remarkable.”
The researchers have already performed the same treatment on silver, making it appear gold, as well as a range of pastel colors.
Harvard’s Office of Technology Development has filed a patent application and is working with the Capasso lab to pursue the commercialization of this new technology, either through a start-up company or through licensing to existing companies. Application areas being explored include consumer products and optical devices, such as filters, displays, photovoltaics, detectors, and modulators.
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On The Net:
Finally, A Robot With The Ingenuity Of MacGyver
Michael Harper for redOrbit.com — Your Universe Online
MacGyver was an admittedly fictitious character who always knew what to do in a pinch. Quickly assessing his surroundings, the secret agent for the Phoenix Foundation would make use of what was available to him and break free from whatever makeshift cell he was being held in. MacGyver wasn´t a real person, of course, but it´s often the characters portrayed on screen which inspire scientific innovation. After all, would we really have iPads if it weren´t for a plethora of Science Fiction movies, such as 2001: A Space Odyssey?
Researchers from Georgia Tech have called upon the late-80s action-adventure television series for some inspiration as they plan to build a robot able to use its own ingenuity to go into a dangerous situation and rescue any who may be in harm´s way.
Aptly dubbed “MacGyver Bot,” this robot will be able to quickly asses its surroundings and know what items can be used, what items pose further danger and who needs to be rescued.
As the world of robotics progresses, these bots have been asked to perform either the most dangerous or the most monotonous of tasks. While it is much safer for robots to enter into these dangerous situations to perform search and rescue missions, these robots are currently able to perform a set list of tasks and are unable to “think” on their own two feet“¦or wheels.
“Our goal is to develop a robot that behaves like MacGyver, the television character from the 1980s who solved complex problems and escaped dangerous situations by using everyday objects and materials he found at hand,” explained Mike Stilman, the leader of the group to develop MacGyver Bot and an assistant professor in the School of Interactive Computing at Georgia Tech.
“We want to understand the basic cognitive processes that allow humans to take advantage of arbitrary objects in their environments as tools. We will achieve this by designing algorithms for robots that make tasks that are impossible for a robot alone possible for a robot with tools.”
To build this robot, Stilman will have to call upon his knowledge of navigation and robotics. In previous research, Stilman created a system by which robots could autonomously recognize different obstacles and move them out of its way as it navigated itself from one point to the next. By building upon this knowledge, Stilman says MacGyver Bot should be able to not only know how to move obstacles out of its way but also use other obstacles and other elements lying around to complete its task.
“This project is challenging because there is a critical difference between moving objects out of the way and using objects to make a way,” said Stilman in a prepared statement.
“Researchers in the robot motion planning field have traditionally used computerized vision systems to locate objects in a cluttered environment to plan collision-free paths, but these systems have not provided any information about the objects´ functions.”
Building an algorithm, Stilman and team hope to “teach” MacGyver Bot some of the basic mechanics of physics and gravity. For instance, MacGyver Bot should one day be able to understand that a simple piece of pipe could be used as a lever or that a fallen ladder could be used to build a bridge over dangerous debris.
Furthermore, this rescue bot could also learn some basic body mechanics, such as how much force should be used to open a jammed door as well as develop a plan with a series of steps to find its way out of harm.
Stilman says MacGyver Bot will be built based upon Golem Krang, the world´s strongest humanoid robot. To get development moving on MacGyver Bot, the US Navy has offered to fund the research by means of a $900,000 grant from the Office of Naval Research. The Navy hopes this robot will one day work hand in hand with service men and women in search and rescue missions.
Link Between Smoking And Cataracts Discovered
redOrbit Staff & Wire Reports – Your Universe Online
Cigarettes have already been linked to a plethora of different diseases and adverse health conditions, and now a new study has found that the smoking could also increase the risk of developing cataracts in some individuals.
Dr. Juan Ye of the Zhejiang University Institute of Ophthalmology and colleagues conducted a meta-analysis, reviewing a dozen cohorts and eight case-control studies from five continents (Africa, Asia, Australia, Europe and North America) to determine smoking’s impact on the development of age-related cataracts, the leading cause of vision loss and blindness in the world.
They looked at the occurrence of age-related cataract in individuals who had smoked cigarettes versus those who had never lit up. They also looked at the differences between former and current smokers, as well as each of the three different types of cataract that can develop in older individuals, the Association for Research and Vision in Ophthalmology (ARVO) explained in an October 12 press release.
“The results showed that every individual that ever smoked cigarettes was associated with an increased risk of age-related cataract, with a higher risk of incidence in current smokers,” they said, adding that “former and current smokers showed a positive association with two of the subtypes: nuclear cataract, when the clouding is in the central nucleus of the eye, and subscapular cataract, when the clouding is in the rear of the lens capsule.”
The study did not find a link between smoking and cortical cataract, a type of cataract in which the cortex of the lens is affected by cloudiness. Their findings have been published in the journal Investigative Ophthalmology & Visual Science (IOVS).
“Although cataracts can be removed surgically to restore sight, many people remain blind from cataracts due to inadequate surgical services and high surgery expenses,” Ye said. “Identifying modifiable risk factors for cataracts may help establish preventive measures and reduce the financial as well as clinical burden caused by the disease.”
“We think our analysis may inspire more high-quality epidemiological studies” the study author added. “Our analysis shows that association between smoking and the risk of age-related cataract differ by subtypes, suggesting that pathophysiologic processes may differ in the different cataract types.”
Georgia Woman Gives Birth To Her Own Grandson
redOrbit Staff & Wire Reports – Your Universe Online
Like any pregnant woman, 45-year-old Angie Stockton carried a child in her womb for nine months before delivering the infant boy earlier this month. The only difference is that she gave birth not to a son, but to a grandson.
According to the Daily Mail, Angie’s daughter Krista Saxon was unable to carry the baby, so she agreed to step in and serve as a gestational carrier for her daughter and her son-in-law, Trent. Baby Tucker was born on October 6, weighing in at 7 pounds, 12 ounces.
“It’s been 26 years since I’ve been pregnant. I’ve forgot a lot of things. So she had to tell me what to expect. It’s funny because she’s the one who ended up with a lot of the pregnancy symptoms,” Stockton, a resident of Athens, Georgia, told local Fox 5 news reporter Kaitlyn Pratt on Friday.
Stockton added that carrying her daughter’s child was just “something I wanted to do” as a mother. Pratt reported that this is believed to be the first time in state history, and just the fourth time in the US, that a grandmother had served as a gestational carrier for her grandchild.
While she said that what she was doing did raise some eyebrows, the parents of the newborn baby boy were just happy to have a new bundle of joy in their lives.
“I was just tickled that he was here and healthy,” Trent Saxon, Tucker’s dad, told Fox 5. “But I was also thinking about putting him in a ball uniform, getting him on a ball field one day.”
“Each day as we got the crib together, put his nursery together, it became more real but I didn’t start thinking ‘oh my gosh I’m about to be a parent,'” added Krista Saxon, according to the Daily Mail. “Until we were getting ready to go into the operating room and then it just hit me like we finally made it.”
Krista and Trent were married three years ago and had planned from the beginning to have a child, but were unable to do so because Krista’s uterus was not fully formed, according to Gannett News Service reports.
She said it was “hard knowing I couldn’t do that for my child” and that she was “lucky to have such a good mother, who’s willing to do anything to help me have the child I wanted.” Krista added that they felt as though their family was now “complete” with the birth of their child — but if she and her husband eventually do decide to have a second child, they told reporters that they will plan to adopt.
Ethiopian Lion Population Proven To Be Unique By DNA
Lee Rannals for redOrbit.com — Your Universe Online
DNA has proven that the Addis Ababa lion in Ethiopia is genetically unique, prompting researchers to urge the animal be put on an endangered species list.
It has been obvious that some lions in Ethiopia have a large, dark mane, extending from the head, neck and chest to the belly, but it wasn’t known if these lions were a genetically distinct population.
Researchers found that captive lions at the Addis Ababa Zoo in Ethiopia are actually genetically distinct from all lion populations both in Africa and Asia.
The team compared DNA samples from 15 Addis Ababa Zoo lions to lion breeds in the wild, including eight males and seven females.
“To our knowledge, the males at Addis Ababa Zoo are the last existing lions to possess this distinctive mane. Both microsatellite and mitochondrial DNA data suggest the zoo lions are genetically distinct from all existing lion populations for which comparative data exist,” principal investigator Professor Michi Hofreiter, of the Department of Biology at the University of York, said in a press release.
He said they believe the lions should be treated as a distinct conservation management unit, and they are asking for immediate conservation actions like a captive breeding program.
Lions are principal terrestrial predators in Africa and are a key species of the savannah ecosystem. However, their numbers are in decline and two significant populations have already become extinct in the wild.
Ethiopia is one region with a declining lion population, which includes just a few hundred wild lions and about 20 Addis Ababa Zoo lions. The zoo lions belonged to the collection of the late emperor of Ethiopia, Haile Selassie. Selassie established the zoo in 1948, and the seven founder lions are claimed to have been captured in south-western Ethiopia.
The team is recommending establishing a captive breeding program as the first step towards conserving this unique lion population.
“A great amount of genetic diversity in lions has most likely already been lost, largely due to human influences,” Susann Bruche, with Imperial College London and lead author of the paper published in the European Journal of Wildlife Research, said in a press release. “Every effort should be made to preserve as much of the lion’s genetic heritage as possible.”
She said they hope field surveys will identify wild relatives of the Addis Ababa Zoo lions in the future, but conserving captive populations is a crucial first step. “Our results show that these zoo lions harbor sufficient genetic diversity to warrant a captive breeding program.”
Previous suggestions said no lions comparable to the Addis Ababa Zoo lions existed in the wild, mostly because they were hunted for their mane. However, Ethiopian authorities say lions with similar appearance to those at the zoo still exist in the east and north-east of the country.
The researchers say these regions should be prioritized for field surveys.
“A key question is which wild population did the zoo lions originate from and whether this wild population still exists; this would obviously make it a priority for conservation,”
“What is clear is that these lions did not originate in the zoo, but come from somewhere in the wild – but not from any of the populations for which comparative data is available,” Hofreiter said in the release.
New Concept Dramatically Alters Theory Of Animal Evolution
April Flowers for redOrbit.com – Your Universe Online
New work by Dr. Stuart A. Newman, professor of cell biology and anatomy at New York Medical College, develops a concept that dramatically alters one of the basic assumptions of the theory of evolution. The assumption is that survival is based on a change’s functional advantage if it is to persist.
Newman, whose life’s work has supported the theory of evolution, offers an alternative model where he proposes that the origination of the structural motifs of animal form were predictable and relatively sudden, with abrupt morphological transformations favored during the early period of animal evolution.
The study will be published in Science, both online and in print. An interview with Dr. Newman will also be released as a podcast.
The most prevalent thought about evolution is that it takes place opportunistically, by small steps. Each change persists, or doesn’t persist, based on its functional advantage. Newman’s model, described in the report, is based on recent inferences about the genetics of the single-celled ancestors of the animals and, more surprisingly, the physics of “middle-scale” materials.
More than a half billion years ago, according to the fossil record, an assortment of recurrent “morphological motifs” first appeared in animal bodies and the embryos that generate them. For present—day animals, cells arrange themselves into tissues having non-mixing layers and interior cavities during embryonic development. Embryos have patterned arrangements of cell types. With these, they form segments, exoskeletons and blood vessels. As the embryos develop, they proceed to fold, elongate, and extend appendages. In some species, they generate endoskeletons with repeating elements, such as the human hand.
The motifs, or recurring forms, in animal embryonic development are remarkably similar to the forms assumed by nonliving condensed, chemically active, viscoelastic materials, when they are organized by relevant physical forces and effects. The mechanisms that create these motifs in living embryos are much more complex, however.
Newman’s new study suggests the ancestors of present-day animals, as a result of ancient single-celled organisms, came to reside in multicellular clusters. The resulting physical processes relevant to matter at this new spatial scale were immediately mobilized.
The single celled organisms are believed to have contained genes of the “developmental-genetic toolkit” that all present-day animals utilize to direct embryonic development, though they used the genes for single-cell functions. The products of these genes enabled the ancestral clusters to produce the characteristic motifs by harnessing the middle-scale physical effects. Different body forms arose in parallel because not every ancestral cluster contained the same “toolkit” genes. This gave rise to the modern morphologically distinct animal phyla.
Over the hundreds of millions of years since the occurrence of these origination events, natural selection has led to the complex developmental processes which have made embryogenesis much less dependent on potentially inconsistent physical determinants. The physical motifs, however, were retained. Newman asserts that this new perspective provides natural interpretations for aspects of early animal evolution, which have been puzzling in the past. This includes the “explosive” rise of complex body forms that appeared between 540 and 640 million years ago and the failure to add new motifs since that time.
This new model also explains the conserved use of the same set of genes to create development in all of the morphologically diverse phyla, and the “embryonic hourglass” of comparative developmental biology. The hourglass is the observation that the species of a phylum can have drastically different trajectories of early embryonic development, but still wind up with very similar body types.
Study Reveals Worst Excuses For Calling Off Sick From Work
redOrbit Staff & Wire Reports – Your Universe Online
We’ve all had to call off work for some reason — illness, doctor’s appointment, death in the family, etc. — but one employment website has compiled some of the worst and most memorable excuses for missing work ever passed along from employee to employer.
CareerBuilder.com, which was founded in 1995 and is operated by Gannett Co, Inc., the Tribune Company, and the McClatchy Company, sponsored a study centered upon employees and their sick days and announced the results on Thursday.
The poll, which was conducted online by Harris Interactive and ran from August 13 through September 6, polled nearly 2,500 human resource professionals and hiring managers and nearly 4,000 workers representing a variety of industry types and company sizes.
According to Forbes staff writer Jacquelyn Smith, approximately 30% of professionals called in sick at least once this year when they weren’t actually ill. “But instead of simply telling their managers, ‘I can´t make it in today because I´m not feeling well,’ they offered much more colorful excuses,” she said.
Among the top 10 excuses that you probably shouldn’t try at home“¦
• Employee´s sobriety tool wouldn’t allow the car to start
• Employee forgot he had been hired for the job
• Employee said her dog was having a nervous breakdown
• Employee´s dead grandmother was being exhumed for a police investigation
• Employee´s toe was stuck in a faucet
• Employee said a bird bit her
• Employee was upset after watching “The Hunger Games”
• Employee got sick from reading too much
• Employee was suffering from a broken heart
• Employee´s hair turned orange from dying her hair at home
“Of course sometimes people are telling the truth and can be found at home under piles of blankets with a thermometer and maximum-strength medicine,” the UK newspaper the Daily Mail said. “But next to actually being sick, the most common reasons employees gave for calling in sick are because they just don’t feel like going to work (34 percent), or because they felt like they needed to relax (29 percent).”
In addition, 22 percent said that they reported off so that they could go to a doctor’s appointment, while 16 percent said that they simply wanted to sneak in a little extra sleep and 15 percent said that they had some errands to run instead. Skipping out on work without a valid excuse can be hazardous to your employment status, though, as 17 percent of employers told CareerBuilder that they had terminated an employee who had given a bogus excuse.
And if you think that there’s no possible way you could be caught, Meg Handley of US News and World Report says you should probably think again. Handley reports that 29 percent of employers had “checked up on” their workers to make sure that the illness was genuine, either by requiring a note from a doctor or by calling the employee at some point during the day. Some of them even reportedly recruited co-workers of the “ill” individual to verify the veracity of the sickness, or driving by the person’s home to sneak a peek themselves.
“Every time we think we´ve seen it all, the next year´s survey always brings in the unexpected,” CareerBuilder VP of Human Resources Rosemary Haefner told Smith. “It´s better to be honest. Keep it short and simple, and only provide the information that is needed“¦ If you´re caught lying, it can have more serious consequences and can bring your professionalism and reliability into question.”
“As an employer, you don´t want to pry into the employee´s personal life, but in some cases you may need more explanation as to why he or she can´t be at work that day,” she added. “If you are taking measures to try to catch an employee, then there clearly is a bigger trust issue at hand. If you don´t trust your employees, it can be difficult to establish a productive and mutually supportive work environment.”
Odd “Sombrero” Uplift Observed In Andean Mountains Due To Magma Chamber
Brett Smith for redOrbit.com – Your Universe Online
Geophysicists at University of California, San Diego (UCSD) have identified a unique phenomenon in Altiplano-Puna plateau, located in the central Andes near the borders of Bolivia, Chile and Argentina.
Magma underneath the Earth´s crust is forcing the ground up in one spot, and at the same time sinking the ground around it. The result is something the researchers have described as the “sombrero uplift,” after the popular Mexican hat.
According to their report on the phenomenon, published in the journal Science, the two UC San Diego scientists recorded uplift in the crust that measured about 0.4 inches per year for 20 years across an area 62 miles wide; the surrounding area sunk at a lower rate–about eight-hundredths of an inch.
“It’s a subtle motion, pushing up little by little every day, but it’s this persistence that makes this uplift unusual. Most other magmatic systems that we know about show episodes of inflation and deflation,” said Yuri Fialko, a professor of geophysics at UCSD and Planetary Physics at the Scripps Institute of Oceanography.
Fialko and co-author Jill Pearse said the phenomenon was the result of a diapir, or a blob of magma, that rises to Earth´s crust like heated wax inside a lava lamp.
Using satellite data from European Remote Sensing (ERS) and Envisat missions, the geophysicists were able to study the uplift in great detail. In 2006, the team asked for the satellites to gather more data from their orbits over Altiplano-Puna.
“It was really important to have good data from different lines of sight, as this allowed us to estimate contributions from vertical and horizontal motion of Earth´s surface, and place crucial constraints on depth and mechanism of the inflation source,” Fialko said.
“Back in 2006, it looked like the satellites stopped acquiring data from the ascending orbits over the area of interest. Fortunately, ESA was very responsive to our requests, and generated an excellent dataset that made our study possible.”
“Satellite data and computer models allowed us to make the important link between what’s observed at the surface and what’s happening with the magma body at depth,” he added.
Fialko said the study´s findings could fuel future research around magmatic events, including the formation of large calderas. Although this diapir in the Altiplano-Puna plateau appears unlikely to cause such a phenomenon–the creation of large calderas, “supervolcanoes,” are highly destructive events that spew thousands of cubic kilometers of magma into the atmosphere. An event of this type would dwarf the Icelandic volcano eruption in 2011 that ejected large amounts of ash into the atmosphere and disrupted global air travel, Fialko said.
Diapirs have been known to exist before, but this new study is the first to recognize an active diapir currently rising through the crust. Fialko said a less prominent uplift phenomenon is taking place near Socorro, New Mexico.
The Altiplano-Puna plateau is a highly active area for magma and is part of a South American volcanic arc that extends along the northwest side of the continent. Experts have described the area as the largest known active magma body in Earth´s continental crust.
Short Bursts Of Exercise Can Burn Calories Throughout The Day
Brett Smith for redOrbit.com – Your Universe Online
Although we all need it–maintaining a regular exercise regimen can be difficult with the demands of everyday life pulling at us from every direction.
However, some exercise is better than none at all and a new study from a group of Colorado researchers supports that notion by demonstrating a few short bursts of intense exercise can burn to up 200 more calories throughout the day.
The researchers, from the University of Colorado and Colorado State University, will present their findings in a presentation entitled, “A Single Session of Sprint Interval Training Increases Total Daily Energy Expenditure,” at The Integrative Biology of Exercise VI meeting this week in Westminster, CO.
“Research shows that many people start an exercise program but just can’t keep it up,” said the study lead author Kyle Sevits of CSU. “The biggest factor people quote is that they don’t have the time to fit in exercise. We hope if exercise can be fit into a smaller period of time, then they may give exercise a go and stick with it.”
Previous studies have shown that an exercise program known as sprint interval training can improve overall fitness and athletic performance. The team decided to investigate how this exercise regimen affects caloric expenditure, a factor that motivates many people to exercise.
In their study, Sevits and colleagues enlisted five healthy male volunteers between the ages of 25 and 31 years old. The participants began the study by undergoing an exercise stress test to make sure they were fit enough to participate in the sprint training. The researchers also recorded the participants´ body compositions and metabolic rates while at rest.
After they were deemed healthy enough to participate, the volunteers ate a specific diet over three days that was designed to meet their metabolic needs and establish an “energy balance,” with just enough calories for their bodies, Sevits explained.
The men then checked into hospital-type rooms at the University of Colorado research facility that were outfitted with a ventilation system designed to analyze oxygen, carbon dioxide and water content. The system allowed researchers to determine how many calories were burned by each volunteer.
For two days, each volunteer continued to eat the balanced diet. They spent the majority of their time doing sedentary activities, but on one of the days, they engaged in the sprint interval workout.
During the workout, each participant would pedal as fast as possible on a stationary bicycle on a high-resistance setting for five 30-second periods, separated by four-minute recovery periods in which they pedaled slowly at a low-resistance setting. The researchers also coached the volunteers over an intercom system during their sprints so that they would give maximum effort.
The ventilation analysis showed that the participants burned an extra 200 calories on the day of their 2.5-minute sprint workout. Researchers were unsure of the mechanism behind the burn, but noted that the results were promising for people trying to squeeze a few minutes of exercise into their schedule.
“Burning an extra 200 calories from these exercises a couple of times a week can help keep away that pound or two that many Americans gain each year,” Sevits noted.
The American government currently recommends 150 minutes of moderate exercise or 75 minutes of vigorous exercise per week.
Early Child-Parent Bond Leads To Positive Emotional Development
Connie K. Ho for redOrbit.com — Your Universe Online
A new study by scientists at the University of Iowa (UI) has determined that parental bonding early on could result in behavioral and emotional benefits for the child.
The study came about from the group´s interest in studying the attachment theory, an important topic in research regarding social and emotional development. In particular, researchers observed that a close relationship between child and parents was less likely to lead to aggressive, troubled or other types of negative emotional behavior during childhood. Interestingly enough, the child only had to feel intimate with one parent to have positive results. The findings, published in the journal Child Development, showcase the importance and impact of parents in a child´s life in the beginning stages of development.
“There is a really important period when a mother or a father should form a secure relationship with their child, and that is during the first two years of life. That period appears to be critical to the child´s social and emotional development,” noted Sanghag Kim, a post-doctoral researcher in psychology at the UI, in a prepared statement. “At least one parent should make that investment.”
The study included observation of 102 infants, who were around 15 months of age, along with one parent of the infant. The scientists then followed up with the parent-child pairings when the child turned eight years old, conducting separate surveys with the child and either the mother or father. The participants´ backgrounds were varied in terms of education, income and race but all were in a heterosexual relationship with their partner.
Apart from observations and surveys with the parent and child, the team of investigators also obtained feedback from teachers who instructed the children in classroom settings. They polled the teachers’ opinions on the child´s inner emotions and outward displays of emotions. They found that the perspectives from the teachers and children were similar in content, while the parents´ evaluations were a bit different.
“Parents and teachers have different perspectives,” remarked Kim in the statement. “They observe children in different contexts and circumstances. That is why we collected data from many informants who know the child.”
Based on the findings, the scientists saw that there was no significant benefit for children who were close to both parents as opposed to children who were close to only one parent. They believe that a positive, secure and warm relationship with one caregiver provides a strong enough foundation for the child´s development. The results of the study could be beneficial for caregivers who may be single mothers or stay-at-home dads.
“Some people think the father is not good enough to be the primary caregiver,” continued Kim in the statement. “Our data show otherwise.”
On the other hand, for children who did not feel comfortable with either parent, these kids showed a mix of aggression, fear and worry when they reached school age. Researchers believe that, apart from the weak relationship with caregivers, there may be other factors at play. The scientists plan to study the issue in further studies, specifically exploring the impact of day-care providers to determine whether these centers offer important emotional support for infants or act more as a barrier for children to bond with parents.
Researchers Show Glaciers Are Cracking In The Presence Of Carbon Dioxide
Alan McStravick for redOrbit.com — Your Universe Online
Our glaciers and ice caps are experiencing a little chemistry-based “good cop, bad cop” and it looks like the bad cop is going to make them crack under pressure.
There is little doubt in the scientific community about the excessive presence at startling levels of carbon dioxide (CO2) in our atmosphere and the effect it is having on our increasing global temperatures and our melting ice caps and glaciers.
Researchers from the Massachusetts Institute of Technology (MIT) wanted to explore the relationship between CO2 and our global refrigerator on a molecular level. Their study, printed today in the Institute of Physics (IOP) Publishing´s Journal of Physics D: Applied Physics, has shown that CO2 molecules may be having a much more direct impact on the ice caps and glaciers than was previously believed.
Specific to the cracking, and breaking up of glaciers and the ice cap, the team learned that the material strength and fracture toughness of ice are severely decreased under increasing concentrations of the CO2 molecule. These higher levels of CO2 make ice caps and glaciers more vulnerable to cracking and splitting into pieces. They believe their results help to explain how the huge crack that had been seen in the Pine Island Glacier in Antarctica eventually gave way, creating a new glacier that is roughly the size of Berlin.
With overall coverage that dwarfs Europe and North America combined, our ice caps and glaciers cover 7 percent of the Globe. They are instrumental in the reflection of 80 percent of the Sun´s light rays that enter our atmosphere, helping to maintain the Earth´s temperature. Unfortunately, they are a natural carbon sink that captures a large amount of CO2.
“If ice caps and glaciers were to continue to crack and break into pieces, their surface area that is exposed to air would be significantly increased, which could lead to accelerated melting and much reduced coverage area on the Earth. The consequences of these changes remain to be explored by the experts, but they might contribute to changes of the global climate,” said lead author of the study Professor Markus Buehler.
Professor Buehler, working with his student and co-author, Zhao Qin, employed a series of atomistic-level computer simulations in order to analyze the dynamics of molecules so as to investigate the role of CO2 molecules in ice fracturing. Their results showed CO2 exposure does, in fact, cause ice to break more easily.
What Buehler and Qin found was the decreased ice strength is not due to material defects in the ice caused simply by CO2 presence, but instead by the fact that the strength of the hydrogen bonds are, themselves, weakened under the increasing concentrations of CO2. Hydrogen bonds are the chemical bonds between water molecules in an ice crystal. The CO2 actually competes with the water molecules connected in the ice crystal.
They were able to show how the CO2 molecules will first adhere to a crack boundary in the ice by forming a bond with the hydrogen atoms. That bond will then travel through the ice, in a flipping motion, along the crack boundary until it reaches the crack tip.
Once the CO2 molecules accumulate at the crack tip they begin a constant barrage on the water molecules in their attempt to bond with them. This process leaves a trail of broken bonds in its wake all the while increasing the brittleness of the ice on a macroscopic scale. And that´s how a bad cop gets his perp to crack. Case closed.
Incentive-Based Crowdsourcing May Be Answer To A Faulty Wikipedia
Michael Harper for redOrbit.com — Your Universe Online
Were it possible to define the whole mass of the Internet in one quip, it might go as follows: “The Internet: Full of people who want to be right“¦and cats.”
That´s the trouble with the luxury of having such large amounts of information so freely available to us. Society can quickly become a mass of people who know so little about everything as opposed to knowing everything about so little, in a sense. Enter crowdsourcing, the means by which Internet-dwellers are asked to pitch in their collective wisdom for the good of the group. Those who are prone to think people are inherently good and want the best for the group might be more inclined to think crowdsource-driven sites, such as Wikipedia, are a great way to broadcast the world´s knowledge. On the other side of the token, there´s much to be said about seeking absolute accuracy over “just good enough.”
Dr. Victor Naroditskiy and Professor Nick Jennings from the University of Southampton are working together to find a way to improve crowdsourcing and find a harmonious balance to strike between these two paradigms.
Along with some help from Masdar Institute´s Professor Iyad Rahwan and Dr. Manuel Cebrian, Research Scientist at the University of California, San Diego, this team have developed some methods to both gather the best information as well as verify the information found within,
Dr. Victor Naroditskiy is the lead author of a paper the team has published in the journal PLoS ONE to describe these new crowdsourcing methods. He explained that while sites like Wikipedia have mechanisms in place to ensure the validity of the information posted, the human element can still throw the proverbial wrench in the gears. After all, to err is human, thus Wikipedia´s hierarchy of trusted editors and contributors who can check the citations and sources of any incoming information.
Crowdsourcing can also be useful when data needs to be collected quickly, as in the case of the Haiti earthquake when volunteers mapped, in real-time, trouble areas where help was needed.
In these time-critical situations, there´s no time for a Wikipedia-style hierarchy of editors.
Dr. Naroditskiy and team have now developed an incentive-based system to verify the best information in a quick manner.
Co-Author Iyad Rahwan explains their system in a statement, saying: “We showed how to combine incentives to recruit participants to verify information. When a participant submits a report, the participant´s recruiter becomes responsible for verifying its correctness.”
“Compensations to the recruiter and to the reporting participant for submitting the correct report, as well as penalties for incorrect reports, ensure that the recruiter will perform verification.”
While the notion of incentives for the best information sounds like an easy fix, one blogger suggests this kind of system essentially lowers the bar all around, outnumbering the true experts by making everyone else “expert-enough.”
“In other words,” writes Michael Martinez, “because no one can be expert enough in all topics to ensure that only correct information is included in a crowdsourced resource the more inexpert contributors a project relies upon the more misinformation will be accepted as reliable.”
“It’s simply a matter of numbers. The expert nodes in the population will always be outnumbered by the inexpert nodes; the expert nodes will always have fewer connections than the inexpert nodes; the expert message will always be propagated more slowly than the inexpert message; and the inexpert message will always win out over the expert message.”
New Melanoma Treatments Destroy The Skin’s Deadliest Predator
Alan McStravick for redOrbit.com – Your Universe Online
Your skin is responsible for keeping you healthy. It covers your internal organs and actively protects them from injury. The dermal layer also acts as a barrier to germs. Additionally, skin can help to regulate your body temperature, with your skin cells communicating directly with the brain to allow sensations of touch, temperature and pain.
For these reasons and more, skin cancers, and more specifically melanomas, are particularly insidious–melanoma being the most serious type of skin cancer. The American Cancer Society estimates that some 75,000 individuals will be diagnosed with this form of skin cancer this year, alone.
Melanoma, the focus of a new study out of Bonn University, is a cancer that begins in the melanocytes — the cells that produce skin coloring or pigment known as melanin. This skin colorant helps to protect you from harmful UV rays.
If caught early on, melanoma can be treated and cured. Otherwise, it can, and usually does, become particularly dangerous, as it metastasizes early on. Its spread is aided by lymphatic vessels and the bloodstream, allowing for quick spread of small tumors. Current treatment models have utilized the body´s own immune system, in conjunction with other methods. Allowing the immune defense to search out and destroy malignant cells is typically only temporarily effective. The research team, whose findings have been published online in the journal Nature, now knows why this is the case.
According to their research, the inflammatory reaction caused by the treatment allows the tumor cells to temporarily alter their external characteristics thus becoming invisible to defense cells. By recognizing this, combination therapies can be altered and improved, hopefully leading to a drastic decrease in the mortality of melanoma.
This most recent study was derived from a working group under Dr. Thomas Tüting, Director of the Laboratory for Experimental Dermatology at the Bonn University Hospital. They have specifically investigated the effect of a targeted immune therapy with tumor-specific defense cells.
The trials they used focused on mice that had developed a congenital form of melanoma. While researchers were able to destroy advanced tumors using cytotoxic T-cells, according to Dr. Jennifer Landsberg and Dr. Judith Kohlmeyer, lead authors of the study, ““¦they [melanoma] recover after some time — just as they do in patients in the hospital.”
Marcel Renn, also a lead author of the study went on to say: “They behave like wolves in sheep´s clothing and thus evade detection and destruction by defense cells.”
As mentioned above, the immune system plays an unwitting role in the spread of melanoma. “The immune system is like a double-edged sword,” according to Dr. Tüting. “It can fight the tumor — but it can also protect it.”
Therapy-resistant melanomas presented a significantly stronger inflammatory reaction with many scavenger cells of the immune system. The study found that messengers released from these immune cells — the tumor necrosis factor-alpha — were able to bring about a change in the character of the melanoma cells directly in the Petri dish in the laboratory. Treated this way, cells were harder to detect by the defense cells.
Recognition of these changes in the tumor tissue is important in that it can lead to the formation of resistance to therapy. “According to more recent discoveries, treatment with inhibitors which prevent signal transmission in tumor cells is also affected by this,” he said.
Viewing the melanoma cells on the molecular level revealed that therapy-resistant tumors had lost the characteristics typical for pigment cells. They actually appeared to demonstrate similar traits with connective tissue cells. “It is possible that melanoma cells undergo this change in character so easily because they originate from the embryonic development of cells in the neural crest which can also form connective tissue and nerve cells,” study coauthor Dr. Michael Hölzel, of the Institute for Clinical Pharmacology and Clinical Chemistry at the Bonn University Hospital, said in a statement.
The team´s findings, which focused on mice in the laboratory, were also able to be reproduced with human melanoma cells as well as with various associated defense cells in the Petri dish. “Detection by other defense cells which can search out specific genetic changes in the melanoma cells was not affected by this, however,” stresses Dr. Thomas Wölfel, director of a working group involved in the study at the Medical Clinic III of the Mainz University Hospital.
Of particular interest was when inflammation subsided due to the tumor necrosis factor-alpha having no more effect on the human and mouse melanoma cells, those cells regained their pigment-cell characteristics. Once this change occurred, the immune defense cells were able to detect and fight the melanoma once more.
This knowledge can be of specific importance to the development of new treatment strategies. The team believes that defense cells against antigens of various categories and specificity should be used in conjunction with therapeutic inhibition of inflammation that targets the tumor cells.
“Our experimental model system will help us to develop optimally effective combination therapies as rapidly as possible,” says Prof. Tüting. “However, it will still take several years until the clinical application of strategies of this type [is realized].”
What is Jupiter?
Hi I’m Emerald Robinson. In this “What Is” video we’ll take a look at Jupiter – the largest planet in the solar system.
Jupiter is aptly named after the Roman king of the gods. It’s the fifth planet from the sun, and the first of the gas giant outer planets. Jupiter is a thousand times larger than the Earth. It’s so large , it has a mass 2 and 1/2 times that of all the other planets in the Solar System combined.
Due to its large mass, Jupiter’s gravity is much greater than that of Earth’s. If you weighed 100 lbs. on Earth you would weigh about 240 lbs. on Jupiter… if you could stand on gas.
Only slightly denser than water, Jupiter is composed of 75% hydrogen and about 25% helium. This ball of gas has no surface, but has a liquid center and small solid core. Jupiter has alternating bands of clouds that spin in opposite directions. Its white bands are known as zones and its dark bands are known as belts.
Jupiter has more than sixty known moons, some of which are as intriguing as Jupiter itself. Io is volcanically active. Europa might be able to harbor life. Callisto, is potentially suitable for a human base. And Ganymede, is the largest moon in the solar system, bigger than both Mercury and Pluto.
Like the other planets, Jupiter has an elliptical orbit. It’s an average of 483.5 million miles from the Sun, and an average of 391 million miles from Earth . It takes Jupiter twelve Earth years to revolve around the sun. But, with the fastest rotation in the solar system, Jupiter’s days zip by. A day on Jupiter is just 10 Earth hours long.
One of the great mysteries of Jupiter is its Great Red Spot. While we don’t know precisely why it’s red, we do know that it’s a colossal storm that’s been kicking up 300 mph winds since it was first spotted over 400 years ago.
No doubt Jupiter and its many moons will continue to provide us with enticing mysteries for many years to come.
Fish Poop May Play Critical Role In Oceans’ Carbon Cycle
Alan McStravick for redOrbit.com – Your Universe Online
Professor Deborah Steinberg of the Virginia Institute of Marine Science (VIMS) has dedicated her professional life to investigating crustaceans and their role in the “biological pump,” which is the process by which marine life transports carbon dioxide from the atmosphere and ocean´s surface to the deep sea. This cycle removes the carbon to a depth where it contributes nothing to global warming.
In a new study published in Tuesday´s issue of Scientific Reports, professor Steinberg partnered with Dr. Grace Saba of Rutgers University and retrained her focus from crustaceans to small forage fish in order to gain an understanding of their role in this carbon removal process.
The research pair collected their data off the coast of southern California on an exploratory expedition aboard the research vessel Point Sur. Building on Steinberg´s knowledge of copepods and other small, drifting marine animals, gleaned from two decades of research, the team wanted to explore whether forage fish like crustaceans played a discernible role in the biological pump through their consumption of photosynthetic surface algae and subsequent release “fecal pellets”.
With copepods, the ingested carbons from the algae are released as fecal pellets which sink quickly into the deep ocean. This is important because the algal cells are generally too small and too light to sink on their own.
“℠Fecal pellet´ is the scientific term for ℠poop,´” laughs Steinberg. “Previous studies in our lab and by other researchers show that zooplankton fecal pellets can sink at rates of hundreds to thousands of feet per day, providing an efficient means of moving carbon to depth. But there have been few studies of fecal pellets from fish, thus the impetus for our project.”
Adding to Steinberg´s comment, Saba says, “We collected fecal pellets produced by northern anchovies, a forage fish, in the Santa Barbara Channel off the coast of southern California.” The researchers found that sinking rates for the anchovies´ fecal pellets averaged around 2,500 feet per day. This figure was arrived at during experiments conducted in the shipboard lab.
At that rate, says Saba, “pellets produced at the surface would travel the 1,600 feet to the seafloor at our study site in less than a day.”
Additionally, Saba and Steinberg determined the overall abundance of the pellets, finding approximately 6 per cubic meter of seawater. This finding, paired with measurements of the pellets´ carbon content — an average of 22 micrograms per pellet — allowed them to create a model that would show the effect that forage fish have on the biological pump.
“Twenty micrograms of carbon might not seem like much,” says Steinberg, “but when you multiply that by the high numbers of forage fish and fecal pellets that can occur within nutrient-rich coastal zones, the numbers can really add up.”
The team´s calculation of the total “downward flux” of carbon within the forage fish fecal pellets saw a maximum figure of 251 milligrams per square meter per day. This figure is equal to or greater than previously measured values of sinking organic matter collected through the use of suspended sediment traps.
“Our findings show that — given the right conditions — fish fecal pellets can transport significant amounts of repackaged surface material to depth, and do so relatively quickly,” says Saba.
Steinberg and Saba believe these conditions are likely to occur commonly on the Pacific coastlines of North and South America. This is because ocean currents abut and even cross over the continental shelves allowing for cold, nutrient-rich waters from depth to move into the sunlit surface zone.
Classic 40-Year-Old Marshmallow Test Gets Revisited With New Study
Lawrence LeBlond for redOrbit.com – Your Universe Online
Breakthrough research in the 1960s that used marshmallows to assess a child´s ability to delay gratification has been revisited with a fresh, new updated study by researchers from the University of Rochester.
In the landmark study from the 60s and 70s, researchers used either marshmallows or cookies to study the effects of child self-control. In those studies, if a child could hold off on the temptation to eat the yummy snack, he or she would be rewarded with more treats later.
In the study, published in the October 11 issue of the journal Cognition, researchers from Rochester University demonstrate that being able to delay gratification is influenced as much by the environment as by instinctive ability. Children participating in the study who experienced reliable interactions immediately before the test began waited on average four times longer (12 minutes versus 3 minutes) than youngsters who were in unreliable situations.
This study follows another published last August in the issue of the Proceedings of the National Academy of Sciences (PNAS), in which study researchers from Cornell University used a group of the same children, now adults, from the earlier experiments from the 60s and 70s, in an updated experiment.
In that study, reported on by redOrbit.com in September 2011, the researchers found that those who were better at delaying gratification as children, showed similar behaviors as adults; and for those who wanted their treat right away as a child, were also more likely to seek instant gratification as an adult. Brain imaging also showed key differences between both groups in two distinct areas: the prefrontal cortex and the ventral striatum.
In the study, participants looked at a screen displaying a series of faces and were asked to signal only when a face of one gender was shown. Called a “cool” test, this experiment revealed no significant differences between the two groups. In the second experiment–the “hot” test– participants were shown faces displaying emotional cues, such as happy, sad and frightened. In this test, researchers found more varied results revealing that aptitude for delayed gratification was consistent from childhood to adulthood.
“In this test, a happy face took the place of the marshmallow. The positive social cue interfered with the low delayer´s ability to suppress his or her actions,” said researchers.
The second test was repeated while the participant´s brain was scanned using functional magnetic resonance imaging (fMRI). The results showed that the brain´s prefrontal cortex was more active for high delayers and the ventral striatum – an area linked to addictions – was more active in low delayers.
“This is the first time we have located the specific brain areas related to delayed gratification. This could have major implications in the treatment of obesity and addictions,” said, at the time, lead author of the study, Dr. B.J. Casey, director of the Sackler Institute for Developmental Psychobiology at Weill Cornell Medical College.
Though following the Cornell study, as well as the past experiments, the new Rochester study looked more closely at why some preschoolers were able to resist the marshmallow while others succumbed to sniffing, licking, nibbling and eventually devouring the little, white, sugary, cylindrical treat.
In their study, the researchers assigned 28 preschoolers between the ages of 3 and 5 to two contrasting environments: reliable and unreliable. The study results were so significant that a larger sample group was not required to ensure statistical accuracy.
Both groups of children were given a create-your-own-cup kit and were asked to decorate some blank paper that would be placed in the cup.
In the unreliable environment group, children were provided a container of used crayons and told that if they could wait, a person would return with a better set of supplies for their project. After about 2.5 minutes, a person returned with an apology that a mistake was made and there would be no better supplies handed out, but asked the children to still create the art project with the original supplies offered.
Next, a quarter-inch sticker was placed on the table and the child was told that if he or she could wait, somebody would return with a large selection of better stickers to use. After the same 2.5-minute wait, the person would return empty handed with another apology.
In the reliable environment group, the same set-up was used, but the researcher always returned with promised materials.
After using these experiments as a base-line, the researchers began the marshmallow test, telling the children they could have “one marshmallow right now. Or–if you can wait for me to get more marshmallows from the other room–you can have two marshmallows to eat instead.”
The researcher removed the art supplies and placed the single marshmallow in a small desert dish on the table in front of the child. Researchers and parents watched a video feed from another room until either fifteen minutes had passed or a marshmallow was eaten, whichever came first. In this phase of the experiment, all children received three additional marshmallows in the end.
“Watching their strategies for waiting was quite entertaining,” said Holly Palmeri, coauthor and coordinator of the Rochester Baby Lab at the University of Rochester.
It was entertaining watching the kids dance in their seats, singing, taking pretend naps; several kids took bites from the bottom of the marshmallow than placed it back in the cup so it looked untouched. Interestingly, a few kids nibbled from both ends, and after realizing they could no longer hide the evidence, devoured the treat, Palmeri explained.
“We had one little boy who grabbed the marshmallow immediately and we thought he was going to eat it,” said Celeste Kidd, a doctoral candidate in brain and cognitive sciences at the University of Rochester and lead author of the study.
Instead he sat on it, Kidd joked. “Instead of covering his eyes, he covered the marshmallow.”
Analysis of the study revealed that children who were in the unreliable environment group waited an average of three minutes and two seconds before succumbing to the gooey goodness of the marshmallow treat. Meanwhile, the children in the reliable environment group held out for an average of 12 minutes and two seconds.
Only one child in the unreliable group held out the full 15 minutes, compared to nine children in the reliable group, noted the researchers.
“Our results definitely temper the popular perception that marshmallow-like tasks are very powerful diagnostics for self-control capacity,” said Kidd.
“Being able to delay gratification–in this case to wait 15 difficult minutes to earn a second marshmallow–not only reflects a child’s capacity for self-control, it also reflects their belief about the practicality of waiting,” Kidd explained. “Delaying gratification is only the rational choice if the child believes a second marshmallow is likely to be delivered after a reasonably short delay.”
Study coauthor, Richard Aslin, the William R. Kenan Professor of brain and cognitive sciences at Rochester, said the findings provide an important reminder about the complexity of human behavior.
“This study is an example of both nature and nurture playing a role“¦We know that to some extent, temperament is clearly inherited, because infants differ in their behaviors from birth. But this experiment provides robust evidence that young children’s action are also based on rational decisions about their environment,” explained Aslin.
Aslin said he was shocked the effect was so large. “I thought that we might get a difference of maybe a minute or so“¦ You don’t see effects like this very often.”
In past research, children´s wait times averaged between 6.08 and 5.71 minutes, the authors reported. By manipulating the environment, wait times doubled in the reliable group and were halved in the unreliable environment.
The authors conclude that manipulating the environment provides strong evidence that children’s wait times reflect rational decision making about the probability of reward. The results are consistent with other research showing that children are sensitive to uncertainty in future rewards.
Aslin noted, however, that parents should not be worried by watching their kids gobble up their treat because of the unreliability they were subjected to in the study.
“Children do monitor the behavior of parents and adults, but it is unlikely that they are keeping detailed records of every single action“¦It’s the overall sense of a parent’s reliability or unreliability that’s going to get through, not every single action,” Aslin explained.
“Don’t do the marshmallow test on your kitchen table and conclude something about your child. It especially would not work with a parent, because your child has all sorts of strong expectations about what a person who loves them very much is likely to do,” added Kidd.
These studies build on the previous gratification research that first started at Stanford University in the 1960s. Walter Mischel and other researchers showed that individual differences in the ability to delay gratification on a simple task correlated strongly with success later in life. Longer wait times as a child were linked years later to higher SAT scores, less instances of substance abuse, and better social skills.
The correlations found in the landmark marshmallow studies have been cited as evidence that qualities like self-control and emotional intelligence may be more important in life than more traditional measures of intelligence, such as IQ testing.
More Younger People Are Suffering Strokes
Alan McStravick for redOrbit.com – Your Universe Online
A scary reality, especially for those of us with aging parents, is the possibility of stroke and its debilitating effects.
When a blood clot blocks an artery or a blood vessel breaks, a stroke or “brain attack” can occur as the flow of blood to the brain is interrupted. With either of these situations, brain cells will begin to die and brain damage occurs.
Many health experts have recognized the need to address a potential stroke as quickly as possible. The acronym F.A.S.T. was developed to help combat the long-term effects of a stroke. F.A.S.T. stands for the four actions you should perform on a loved one you believe is having a stroke.
• FACE: Ask your loved one to smile. Does one side of his or her face droop?
• ARMS: Ask your loved one to raise both arms. Does one arm drift downward?
• SPEECH: Ask your loved one to repeat a simple phrase. Does his or her speech sound slurred or strange?
• TIME: If you observe any of these signs, it’s time to call 911.
Time really is of the essence. This is because when brain cells die during a stroke, the functions controlled by that area of the brain are lost. With just a few lost minutes, a stroke victim can lose speech, movement and/or memory. While some people have had complete recoveries after their stroke, it is estimated that a full 2/3 of survivors will have some type of lasting disability.
Our aging parents aren´t the only ones we should be keeping an eye on, however. Another target demographic has been recognized in a new study. To get a good idea of who is in this new group, all many of us need do is look in a mirror.
Published Wednesday in the online issue of Neurology, new research has shown that stroke may be affecting people at a younger age.
“The reasons for this trend could be a rise in risk factors such as diabetes, obesity and high cholesterol,” said study author Brett Kissela, MD, MS, with the University of Cincinnati College of Medicine in Ohio and a Fellow of the American Academy of Neurology. “Other factors, such as improved diagnosis through the increased use of MRI imaging may also be contributing. Regardless, the rising trend found in our study is of great concern for public health because strokes in younger people translate to greater lifetime disability.”
The study, conducted over 3 distinct one year-long periods, paid special attention to the occurrence of strokes in people aged 20-54. They also only included in the study persons experiencing their first ever stroke.
In the twelve years that spanned the entirety of the study, researchers found the average age of someone who experienced stroke fell from 71, in 1994, to 69 years of age in 2005. Additionally, they found that strokes among people under age 55 made up a greater percentage of all strokes over time, growing from an estimated 13 percent in the 1993-94 study up to 19 percent in 2005. This increase was seen in both Caucasian and African-American populations.
“The good news is that some of the possible contributing factors to these strokes can be modified with lifestyle changes, such as diet and exercise,” said Kissela. “However, given the increase in stroke among those younger than 55, younger adults should see a doctor regularly to monitor their overall health and risk for stroke and heart disease.”
If we are to look for a silver lining for this study, it is that we know that over the same time as the observations were made (1993-2005), the mortality rate associated with stroke actually declined 30 percent.
Responsible as the third leading cause of death in the United States, strokes kill more than 140,000 people each year and it is the leading cause of serious, long-term disability in the U.S. It is estimated that every 40 seconds someone suffers a stroke. Smokers and persons with high blood pressure are at a significantly higher risk for stroke.
Cancer Cells Spread Through The Body Via Adhesion Molecules
Connie K. Ho for redOrbit.com — Your Universe Online
A new study from the Massachusetts Institute of Technology (MIT) has revealed that cancer cells break away from tumors via adhesion molecules, causing a spread of cancer throughout the body.
The findings from the research project were recently published in the journal Nature Communications and offer a glimpse into the possible development of cancer drug targets.
“As cancer cells become more metastatic, there can be a loss of adhesion to normal tissue structures. Then, as they become more aggressive, they gain the ability to stick to, and grow on, molecules that are not normally found in healthy tissues but are found in sites of tumor metastases,” remarked lead researcher Sangeeta Bhatia, a member of the David H. Koch Institute for Integrative Cancer Research at MIT, in a prepared statement. “If we can prevent them from growing at these new sites, we may be able to interfere with metastatic disease.”
According to the scientists, cells are usually attached to the extracellular matrix, a structural support system, in the body. The matrix assists in managing cellular behavior and the cells are held down with the help of integrins, a type of protein found on cell surfaces. These proteins let go of the cells when cancer cells metastasize.
In particular, the researchers looked at the adhesion properties of cancer cells from primary lung tumors that metastasized later, primary lung tumors that did not metastasize, metastatic tumors that moved to farther locations in the body, and metastatic tumors that moved to lymph nodes close by. Each type of cell was exposed to a different pair of molecules from the extracellular matrix. In particular, there was a pair of extracellular matrix molecules that were especially adhesive to fibronectin and galectin, which are made of proteins that attach to sugars. The scientists then recorded how the cells were attached to the protein pairs.
Based on the results of the project, the team of investigators believes that the technology can be utilized in future studies on cellular adhesion.
“They´ve not only scaled this up dramatically, they´re able to study the adhesion proteins in combination, which allows them to identify adhesion synergies,” noted Dr. Jan Pilch, an assistant professor at the University of Pittsburgh School of Medicine who is unaffiliated with the study, in the statement.
The team of investigators was surprised to discover that the cells from the metastatic tumors were similar to each other as opposed to similar to the cells of the primary tumor. Even though the metastatic cells are similar in adhesive qualities, they can move in different directions; some cells will change the mix of integrins expressed, while others will modify the sugars found on cell surfaces.
Past studies have shown that tumors can lead to metastasis as a result of the secretion of molecules that increases the growth of an environment that is conducive to cancer development. In particular, more galectin-3 is correlated with more aggressive metastasis. An increase in galectin-3 and other molecules that encourage tumor cells to grow may affect the process.
“There´s a lot of evidence to suggest that a hospitable niche for the tumor cells is being established prior to the cells even arriving and establishing a home there,” concluded the study´s lead author Nathan Reticker-Flynn, a doctoral student in Bhatia´s lab.
Immune System Uses Vitamin B To Recognize Infection
Connie K. Ho for redOrbit.com — Your Universe Online
Researchers from the University of Melbourne and Monash University in Australia recently studied how the body utilizes vitamin B to recognize bacterial infection, allowing the body´s specialized immune cells to defend against infection.
Medical experts have long touted vitamin B as an important element in healthy living. According to the American Cancer Society, vitamin B is necessary for growth and development. It can affect the activity of enzymes, which regulate chemical reactions in the body as well as change food into energy.
In particular, the study is the first of its kind to highlight how the highly abundant mucosal associated invariant T cells, otherwise known as MAIT cells, identify the vitamin B production from bacteria and yeast. The scientists believe that the immune receptor MR1 can capture some of the by-products of bacterial vitamin synthesis, allowing the MAIT cells to work effectively.
“Humans are unable to make vitamin B and obtain it mostly from diet. Because bacteria can synthesize vitamin B, our immune system uses this as a point of difference to recognize infection,” explained researcher Dr. Lars Kjer-Nielsen of the University of Melbourne in a prepared statement. “Given the relative abundance of the MAIT cells lining mucosal and other surfaces, such as the intestine, the mouth, lungs, it is quite probable that they play a protective role in many infections from thrush to tuberculosis.”
The team of investigators believes that the study´s findings pave the way for further research on immunity and infection.
“This is a significant discovery that unravels the long sought target of MAIT cells and their role in immunity to infection,” noted Kjer-Nielsen in the statement.
As well, the results of the study will help in the development of vaccines and other possible pharmaceuticals.
“This is a major breakthrough in which Australian researchers have beaten many strong research teams around the world, becoming the first to unlock the mystery of what drives a key component of our immune system,” commented James McCluskey, a professor of the Department of Microbiology and Immunology at the University of Melbourne, in the statement.
Furthermore, the study has allowed the researchers to understand the relationship between the body´s immune system and gut bacteria.
“Some vitamin by-products appear to drive immunity while others dampen it,” explained Jamie Rossjohn, a professor at Monash University, in the statement.
The researchers plan to continue the project and hope to study how MAIT cells could also be related to intestinal or muscular disorders like inflammatory bowel disease or irritable bowel syndrome.
“This discovery now cracks open a new field in immunology and we can expect many research groups to focus their attention on this system,” continued Rossjohn in the statement.
The Australian Research Council along with the National Health and Medical Research Council of Australia provided funding for the project.
The findings are published in the journal Nature.
Fossil Find Suggests Complex Brains Developed Earlier Than Previously Believed
April Flowers for redOrbit.com – Your Universe Online
Anatomically complex brains evolved earlier than previously thought and have changed little over the course of time, according to a new study by University of Arizona neurobiologist Nicholas Strausfeld. The specimen described in the study, which will be published in the October 11 issue of Nature, is the earliest known fossil to show a brain.
The three inch long fossil was discovered embedded in mudstones deposited during the Cambrian period 520 million years ago in what is currently the Yunnan Province in China. It belongs to the species Fuxianhuia protensa, an extinct lineage of arthropods that combines advanced brain anatomy with a primitive body plan.
Arthropods are the taxonomic group that is comprised of crustaceans, arachnids and insects. This fossil represents a missing link that may shed light on the evolutionary history of the group. The research team thinks this fossil could resolve a long-standing debate about how and when complex brains evolved, calling the find a “transformative discovery.”
“No one expected such an advanced brain would have evolved so early in the history of multicellular animals,” said Strausfeld, a Regents Professor in the UA department of neuroscience. Paleontologists and evolutionary biologists disagree on how arthropods evolved, especially, according to Strausfeld, about what the common ancestor looked like that gave rise to insects. Until now, the scientific community has favored one of two scenarios.
Some scientists believe that insects evolved from an ancestor that gave rise to malacostracans. Malacostracans are a group of crustaceans that include crabs and shrimp. Other scientists point to a lineage of less commonly known crustaceans called branchiopods, which include brine shrimp.
Branchiopod brain anatomy is much simpler than that of malacostracans, leading to the theory that the branchiopods were the more likely ancestors of the arthropod lineage. The discovery of a complex brain anatomy in an otherwise primitive organism like Fuxianhuia makes it unlikely that the branchiopods are the common ancestor.
“The shape [of the fossilized brain] matches that of a comparable sized modern malacostracan,” the authors write. The fossil supports the second hypothesis, which states that the branchiopod brains evolved from a previously complex to a more simple architecture instead of the other way around.
This second hypothesis arises from neurocladistics, a field pioneered by Strausfeld. Neurocladistics attempts to reconstruct the evolutionary relationships among organisms based on the anatomy of their nervous system. On the other hand, conventional cladistics usually look to an organism’s overall morphology or molecular data such as DNA sequences to reconstruct the evolutionary relationships.
Strausfeld has cataloged approximately 140 character traits detailing the neural anatomies of almost 40 arthropod groups.
“There have been all sorts of implications why branchiopods shouldn´t be the ancestors of insects,” he said. “Many of us thought the proof in the pudding would be a fossil that would show a malacostracan-like brain in a creature that lived long before the origin of the branchiopods; and bingo! — this is what this is.”
Strausfeld collaborated with Xiaoya Ma, a postdoctoral fellow at London’s Natural History Museum, in studying the brain anatomies of various fossil specimens at the Yunnan Key Laboratory for Palaeobiology at Yunnan University.
“I spent a frenetic five hours at the dissecting microscope, the last hours of my visit there, photographing, photographing, photographing,” he said. “And I realized that this brain actually comprises three successive neuropils in the optic regions, which is a trait of malacostracans, not branchiopods.”
The portions of the arthropod brain that serve particular functions — like collecting and processing input from sensory organs — are called neuropils. Scent receptors in the antennae are wired to the olfactory neuropils, for example, while the eyes connect to neuropils in the optic lobes.
By tracing the fossilized outlines of Fuxianhuia’s brain, Strausfeld realized it had three optic neuropils on each side that once were probably connected by nerve fibers in crosswise patterns such that occurs in insects and malacostracans. The brain also has three fused segments, unlike branchiopods, which only have two fused segments.
“In branchiopods, there are always only two visual neuropils and they are not linked by crossing fibers,” Strausfeld said. “In principle, Fuxianhuia´s is a very modern brain in an ancient animal.”
“This fossil provides the most convincing, and certainly the oldest, description of nervous-system tissue in a fossil arthropod,” Graham Budd of Uppsala University Earth Sciences Department wrote in a comment on the study according to the AFP news agency.
The study claims that this fossil supports the idea that once a basic brain design evolved, it changed little over time. Instead, peripheral components such as the eyes, antennae, and other appendages and sensory organs underwent great diversification. They specialized in different tasks, but all plugged into the same basic circuitry.
“It is remarkable how constant the ground pattern of the nervous system has remained for probably more than 550 million years,” Strausfeld added. “The basic organization of the computational circuitry that deals, say, with smelling, appears to be the same as the one that deals with vision, or mechanical sensation.”
“In principle, Fuxianhuia’s is a very modern brain in an ancient animal,” added Strausfeld.
“It is remarkable how constant the ground pattern of the nervous system has remained for probably more than 550 million years.”
While Dragon Survives, One Satellite Failed After Engine Anomaly
Lee Rannals for redOrbit.com – Your Universe Online
While the Dragon capsule was able to survive an engine failure with the Falcon 9 rocket on Sunday, news broke that a satellite aboard a secondary payload suffered from the event.
SpaceX launched its Falcon 9 rocket on Sunday, with both the Dragon capsule and Orbcomm‘s prototype OG2 communication satellite onboard.
During launch, one of the rocket’s nine Merlin engines lost pressure and suddenly shutdown, leaving its secondary mission in jeopardy.
The Dragon capsule jettisoned from the rocket, and was able to dock with the International Space Station on Wednesday morning, however, the satellite didn’t have the same successful outcome.
Orbcomm said in a statement that the satellite was deployed in the wrong orbit, missing its mark by possibly between 200 to 300 miles, according to Jonathan’s Space Report as reprinted by Reuters.
The company said an analysis has begun to determine if the satellite can use its onboard propulsion system to boost its orbit.
The initial plan for the satellite was for it to launch into orbit after leaving Earth’s atmosphere on the back of the Falcon 9, but the OG2 missed its target because of the engine loss.
The satellite was the first of 18 OG2 satellites that will be carried into space aboard a Falcon 9 rocket.
Orbcomm said they are currently in contact with the satellite to see if they can get it to rise in orbit.
Falcon 9 was able to complete its primary mission of getting the Dragon capsule at a place where it could resupply the International Space Station.
Early Wednesday morning, Expedition 33 Commander Suni Williams used the station’s Canadarm2 robotic arm to snag the Dragon and place it in its docking port.
Dragon is scheduled to spend 18 days attached to the station, during which the crew will unload 882 pounds of crew supplies, science research and hardware from the cargo craft and reload it with 1,673 pounds of cargo for return to Earth.
Dragon will be detached from the Harmony module on October 28, and will be released by ISS for a splashdown in the Pacific Ocean.
This was the first official resupply mission SpaceX has been contracted out to do. Dragon will have 11 more to do after this mission.
Expert Warns People Cleaning Camps, Cabins This Fall To Take Precautions Against Possible Hantavirus
Lawrence LeBlond for redOrbit.com – Your Universe Online
The hunting season is upon us and that means thousands of people will be heading into the woods to deer camps and cabins for their yearly ritual. And for those who will be cleaning out and camping at these cabins, precautions should be taken to avoid a possible viral infection similar to one that has plagued California´s Yosemite National Park this summer.
The warning comes from David Wolfgang, director of Veterinary and Biomedical Sciences at Penn State´s College of Agricultural Medicine. Wolfgang said that hantavirus has killed several people in Pennsylvania over the years, and many more throughout the country since it was first discovered in the US in 1993.
While the threat of hantavirus is greater this year than in previous years, mainly due to an increased population of certain mice species that can carry the virus, Wolfgang emphasized that caution–but not panic–is warranted.
Before 2012, data from the US Centers for Disease Control and Prevention (CDC) showed that 587 cases of hantavirus pulmonary syndrome (HPS) have been reported in the US. Of these cases, 556 occurred following the initial discovery of HPS in 1993. About 36 percent of all HPS cases reported have been fatal (roughly 200 people).
“Several species of wild rodents, such as the deer mouse and the white-footed mouse, have been linked to the virus,” said Wolfgang. “You could be at risk when opening or cleaning a hunting camp or cabin — that may put you in contact with rodent droppings, urine or nesting materials.”
Because the virus enters the body when contaminated dust is inhaled, people should wear masks while cleaning camps out, especially if there is a sign of rodent infestation. Rodent feces and urine, once dry can be stirred up with dust, making it easily inhalable.
Once hantavirus gets into your system, HPS can set in. HPS is a serious, acute lung disease that causes the lungs to fill with fluid, explained Wolfgang.
He noted that the CDC website has a listing of precautions that should be taken when interacting with areas that may have, or have had, rodent infestations.
Some of these precautions include: wash all dishes and utensils in hot soapy water before use, store food in rodent-proof containers, ensure that bedding, pillows and sleeping bags are clean, and launder them before use if they may have been contaminated by rodents. To keep further infestations from occurring, block holes and fill cracks where rodents may be able to enter.
Once buildings have been opened, it is a good idea to let them air out for at least 30 minutes before cleaning. Wearing rubber gloves and a protective mask is also a good idea. Spray all materials and surfaces thoroughly with disinfectant, especially areas where droppings and urine are suspected. For larger areas, a bleach solution may be necessary.
“Be especially careful with vacuum cleaners,” warned Wolfgang. “The dampened rodent droppings should be carefully picked up as described and not picked up with a vacuum cleaner, because this may aerosolize the virus and put you at greater risk.”
Also, sleeping on the floor or around walls where rodents may have trafficked is a risk factor as well, he noted. “Those areas should be thoroughly cleaned prior to sleeping with your face close to potentially contaminated surfaces.”
After cleaning, all materials used should be buried, burned or disposed of appropriately. Gloves should be disinfected before removing them, and washing your hands with soap and hot water immediately afterward should provide a proper amount of protection from infection.
“The symptoms of the disease are nonspecific and include fever, fatigue and muscle aches,” said Wolfgang. “Patients also may experience headaches, dizziness, chills and abdominal problems. Symptoms may begin one to five weeks after exposure.”
After four to 10 days, some patients may experience coughing and shortness of breath, he added. “If symptoms occur, check with your physician and mention that you may have been exposed to rodent contamination.”
While the disease is rare, Wolfgang said it is “important that people are aware of the potential when they clean out cabins or hunting camps.”
Researchers Find Cougar Migration Patterns Not What They Expected
Alan McStravick for redOrbit.com – Your Universe Online
In a recent study that appeared online in the August early-view edition of the journal Molecular Ecology, researchers looked at DNA in tissue samples that had been collected from 739 mountain lions over a period of seven years. The purpose of the study, the first to be conducted on such a large scale, was to discover population structures and history and to identify “sinks” and “sources” in the region.
A “sink” is a habitat to which animals move at a greater rate than the area from where they have dispersed. Conversely, a “source” would be an area from which animals leave to live elsewhere at a greater rate than they come.
The authors of the study were Alyson M. Andreasen, a doctoral candidate from the University of Nevada, Jon P. Beckmann of the Wildlife Conservation Society (WCS), and Matthew L. Forester, William S. Longland and Kelley M. Stewart of the University of Nevada.
Prior to culling data, researchers believed that the mountain lions had a fairly steady eastward movement. The fact that the mountain lion can be hunted in Nevada and not in California led researchers to assume that populations would migrate eastward to take over lands left available after hunters would have killed the native mountain lions.
What they found, however, was quite different. The mountain lions moved in a mostly northern and southerly direction following the topography of the mountain ranges in the region. This resulted in distinctly different genetic populations. East or west directional movement showed that more mountain lions moved west from Central Nevada to the mountains of the Sierra Nevada. The new assumption is that mountain lions migrated to California to take advantage of better habitat quality.
Lead author of the study, Alyson Andreasen, said, “The results are surprising and telling in that in most situations where you have hunting, the animals move in the direction of the resultant vacant territories. While this appears to be occurring in other areas of the state, habitat differences between the Sierra Nevada and the arid Great Basin may be attracting dispersal age mountain lions west into California whereas the abrupt ecotone may act as a barrier for lions residing in the Sierra Nevada.”
An ecotone is a transitional area of vegetation between two different plant communities like a forest and grassland. Ecotones have some of the characteristics of each bordering biological community, but they may also have species not found in the overlapping communities.
The study´s co-author Jon Beckmann stated: “In this case, a hunted population is the source for the non-hunted/protected population. This is somewhat counterintuitive: Some might think that in remote mountainous terrain of Nevada, the impacts of hunting on lion populations would outweigh those associated with more people and roadways in the Sierra of California but this appears to not be the case.
“We predicted we would have more lions coming in from California. We were surprised the Sierra itself was a net importer,” Beckmann continued.
“It may just be more attractive to move into the Sierra Nevada,” said Alyson Andreasen, a University of Nevada doctoral student and a lead researcher in the study.
“It’s just conjecture at this point, but that’s what we think might be going on.”
Researchers believe the lusher habitat and greater prey selection of the Sierra region was more attractive than the arid mountains of Nevada.
Populations of mountain lions in the area, according to estimates reported in the San Jose Mercury News, range between 4,000 to 6,000 in California compared to about 3,000 in Nevada.
Following multiple generations, the study has provided information that will be particularly useful when it comes to managing cougar populations and will serve as a launching point for future studies to determine how mountain lions interact with other species and how they select habitat in the region.
Norwegian Study Finds A Third Of Child Car Restraints Done Incorrectly
Alan McStravick for redOrbit.com – Your Universe Online
The vulnerability of childhood, through the mazes of discovery and social interaction, has another startling factor to contend with. In a new study published by the Norwegian Institute of Public Health, it has been determined that car accidents are the main cause of serious injury and death among children in that country.
The study showed that 37 percent of all children under the age of 16 use safety restraints incorrectly. Additionally, they found that 23 percent of children are so poorly restrained that a collision would likely have serious consequences. Dr. Marianne Skjerven-Martinsen presented the “Barn i Bil” (Children in the Car) team´s findings at a seminar on traffic accidents held in Oslo, Norway yesterday.
Speaking at the Institute´s Division of Forensic Medicine and Drug Abuse Research, Skjerven-Martinsen said: “With the correct use of safety equipment, fewer children will be injured and killed in traffic.”
Their study was conducted from April through August of 2011 and used a total of six roadside studies in conjunction with local traffic police. Researchers and law enforcement officials stopped cars in weekend traffic to examine how children in the vehicles were secured. They focused on high-speed roads located in the southeast of Norway.
In all, 1,260 children under the age of 16 were included in the study. Researchers found that the highest vulnerability for safety error was for children between the ages of 4 to 7, a critical time between toddler age and adolescence. They also found that 5 common mistakes occurred irrespective of the age of the children. These included misplaced seat belts, twisted belts, loose straps, belts under the arm instead of over the shoulder, and young children in seats without proper side support.
“We see that adults want to use the equipment to protect their children, but they may lack knowledge of what can go wrong if they do not use the equipment properly. The aim of this study was to evaluate the use of incorrect child restraint in the car, according to the child’s height, age and type of equipment. Thus we can give advice to parents, authorities and especially to industry on how to avoid incorrect restraint,” explained Marianne Skjerven-Martinsen.
Studies have also been conducted in the U.S. that have affected public policy related to child safety. Notably, in Colorado, child passenger laws were expanded in August of 2010. Their law broadened to include supplemental restraints of children in automobiles to include kids up to the age of 8.
Mirroring the findings above about the particular vulnerability of children aged 4 to 7, Colorado´s law change meant that thousands of 6 and 7 year olds would have to ride on a booster seat. A booster seat can lift the child sufficiently, making the use of the regular belt more effective in a crash, as the lap belt can rest across the hip bones, protecting vital internal organs.
Colorado´s previous law had exempted children after age 5. While not required by law, it is recommended children use a booster seat until they are at least 4´ 9” tall, regardless of their age.
In support of the law, Colorado even created 140 “fitting stations” across their state. Most of these stations provide free assistance to parents, helping them to properly secure seats through proper installation.
And closer to Norway, the U.K. also recently passed stringent child safety protection laws, including a minimum height provision. British children are required to be properly restrained in vehicles until the age of 12 , or a height of about 4´ 4”. They place the full responsibility on the driver of the vehicle to ensure proper safety restraint for every passenger under the age of 14.
The “Barn i Bil” project of Norway has conducted previous studies as well. One in particular, conducted between 2007 and 2009, focused on car accidents in which one occupant was seriously injured or even killed and where there were children present in the car. They were able to perform studies examining the accident scene, the vehicles and the child restraint systems within the first 24 hours of the accident. Interviews with response personnel and witnesses were conducted along with detailed clinical examinations of the injured children and autopsies of the children who were killed.
“In this study we found that 52 per cent of the children who were injured or killed were not well enough restrained. Belts out of position or loose belts were the most common mistake, and were involved in several cases of serious injury or death. We also saw examples of loose objects in the car that could cause serious physical injury in an accident by hitting the children directly or through seat movement,” concluded Skjerven Martinsen.
As the Barn i Bil project continues, all serious car accidents in the southeast of Norway that have children in the car are being investigated. They have, thus far, more than 100 accidents and the data mined from them, included in their study. Results from that study are scheduled to be published in the spring of next year.
Visible LEDs Celebrate Their 50th Birthday
Lee Rannals for redOrbit.com — Your Universe Online
One technology has only just begun to be implemented into our society on a wide-scale, but it has actually been around for 50 years: the LED.
The world’s first visible light-emitting diode (LED) was demonstrated in 1962 by Nick Holonyak, Jr. to General Electric suits.
Holonyak had predicted that the LED would replace incandescent lights, but at the time he probably didn’t realize it would take 50 years to gain some traction.
The scientists at GE Advanced Semiconductor Laboratory were researching a way to create energy-efficient visible light from LEDs.
Before 1962, the only light emitted from LEDs was infrared, so researchers were trying to produce a visible LED.
Holonyak used a mixture of gallium arsenide and gallium phosphide (GaAs phosphide) to make LEDs work on the visible light spectrum.
After showing off his feat to GE executives, Holonyak predicted in the February 1963 issue of Reader’s Digest that the LED would eventually replace incandescent bulbs.
While the first visible LED light was red, it took 10 more years for Dr. M. George Craford to create the first yellow LED in 1972.
Back in 1968, producing visible and infrared LEDs could cost $200 per unit, making the idea of using the lighting system instead of incandescent bulbs seem impractical. However, with the prices of the lights going down, and governmental regulations on incandescent bulbs increasing, it took 50 years for Holonyak to see his 1963 prediction finally start coming to fruition.
Now, LED light bulbs are being sold in stores to be used in place of incandescent. Many cities have even started to replace their street lamps with the 50-year-old technology.
Christmas lights have begun to conform to the technology and TVs have started to adapt, as well. LEDs are proving to be more energy efficient and more cost effective over the long run. They last longer than incandescent light bulbs and they consume far less energy in use.
Holonyak created something 50 years ago that was ahead of its time. Now, time has finally caught up with it and the visible LED bulbs are finding their place in the modern world.
Data Storage: Cheaper And Easier With Photonics
Michael Harper for redOrbit.com — Your Universe Online
As technology grows and components shrink, data storage usually follows suit, with ever-increasing capacities being packed into the tiniest of spaces.
It´s an interesting paradigm, for sure.
Though their needs are drastically different, consumers, researchers and scientists alike ask for the same thing: More available space packed in a smaller package. The rapid advancement in this area has already given many pause to contemplate how a handful of megabytes was once considered precious real estate. These days, the same amount of data is instantly streamed and then forgotten on our smartphones.
And though we´ve come a long way since the early days of data storage, the push towards more on less trudges ever onward, ensuring one day soon we´ll look back and remember when we thought the idea of storing the whole of the Library of Congress on only 5 compact discs was simply crazy.
Thanks to a new technology developed by Case Western Reserve University researchers, this kind of massive storage on a tiny optical disk could be possible in coming years. With this new technology, optical discs could be capable of bearing the weight of 1 to 2 TERABYTES of data, providing not only an easier and more flexible way of storing data, but a cheaper way as well.
Compact discs, DVDs and Blu-Rays are, and always will be, cheaper to buy than spinning drives, and cheaper to read and maintain as well.
To jumpstart this technology and get it into the hands of small and medium sized businesses sooner, these researchers have launched a company called Folio Photonics.
“A disc will be on the capacity scale of magnetic tapes used for archival data storage,” explains Kenneth Singer, Ambrose Swasey professor of physics and co-founder of Folio Photonics, in a press release.
“But, they´ll be substantially cheaper and have one advantage: you can access data faster. You just pop the disc in your computer and you can find the data in seconds. Tapes can take minutes to wind through to locate particular data.”
The technology to be used by Folio Photonics isn´t much different from that used to create and write Blu-Ray discs: The data is actually stored in layers on the disc, as opposed to being spread out on a flat surface. Blu-Ray discs are able to get much more data and, therefore, sharper images because they can cram this information in a smaller place, then stack layers of this information on top of one another.
Folio Photonics will use a similar method, writing large amounts of data on each individual layer, then stacking them dozens of layers high. To make these layers, a machine melts down polymers into a film, then repeatedly divides and stacks this film on top of itself, similar to how the dough for a croissant is made. The team at Folio Photonics say they´re able to produce a square kilometer of this stacked film in under an hour.
The data is then written on this film and pasted onto the familiar plastic base all CDs, DVDs and Blu-Rays are built upon.
The team also say they only need to make minor adjustments to a standard disc reader in order for these layered discs to be able to be read. According to their introductory video, these layers are able to be pierced with the optical laser and read with very little interference from the other layers, resulting in a clear, sharp image with very little signal-to-noise ratio.
Folio Photonics plans their discs to be used by companies who regularly dump their data to make room for more data, but need to continue archiving backups.
Liquid Nitrogen And Food: A Potentially Lethal Concoction
April Flowers for redOrbit.com – Your Universe Online
In the UK last week, an 18 year old woman’s birthday celebration ended in emergency surgery to remove her perforated stomach. The cause: a cocktail prepared using liquid nitrogen. The tragedy has prompted an intense look at the use of liquid nitrogen in food and beverage preparation.
Gaby Scanlon ingested the “correctly prepared Jagermeister drink made with liquid nitrogen” at her 18th birthday celebration. Shortly thereafter she began to feel sick, “becoming breathless and developing severe stomach pain.” When Gaby reached the hospital, she was diagnosed with a perforated stomach, which had to be removed.
Dr. Malcolm Povey, professor of food physics at Leeds University, explains what probably happened to Gaby.
“The liquid nitrogen would rapidly change into gas and blow the stomach up like a balloon,” he said. “The idea that people put this stuff in drinks is just unbelievable.”
At a boiling point of -196C, liquid nitrogen is used for a variety of industrial applications including coolant for computers, to remove skin growths and cancers, and in cryogenic studies where scientists examine the effects of very cold temperatures on materials.
Top restaurants have increasingly used it as a method for instantly freezing food and drinks, or creating a cloud or vapor special effect. Chef Heston Blumenthal made the avant-garde cooking technique famous with his nitro-scrambled egg and bacon ice cream and nitro-parched aperitifs at his Berkshire, UK, restaurant, the Fat Duck.
Since then, it has become a popular technique at restaurants and dozens of recipes have shown up on the internet.
University of Bristol’s School of Physics Professor Peter Barham says that liquid nitrogen is “simply the harmless gas nitrogen, which has been cooled to such a low temperature that it becomes a liquid”.
If not handled properly, Barham says, the liquefied gas can cause frostbite or cryogenic burns. Using it in cooking is fine, as long as proper safety measures are taken.
“If liquid nitrogen is added to a liquid such as an ice-cream mixture, it cools the liquid rapidly while it boils away and produces a cloud of vapor. The technique is used by some restaurants to prepare instant ice creams at the table – the rapid freezing produces an ice cream with particularly small ice crystals which has a very smooth texture,” he says.
Ingesting liquid nitrogen should never be done, and it is essential that all the liquid has evaporated before any food or drink prepared with it is used.
Gaby Scanlon’s tragedy has prompted the UK’s Food Standards Agency to issue a warning, telling consumers to “take care when drinking cocktails made with this substance.”
Director of public health for the county of Cumbria, Dr. John Ashton said that Gaby was “the victim of an irresponsible alcohol industry that’s now competing on gimmicks.” The police say the bar involved has suspended selling drinks prepared with liquid nitrogen and is cooperating with the investigation.
John Emsley, science writer and fellow at the Royal Society of Chemistry, says that if more than a “trivial” amount of liquid nitrogen is swallowed the results are disastrous.
“If you drank more than a few drops of liquid nitrogen, certainly a teaspoon, it would freeze, and become solid and brittle like glass. Imagine if that happened in the alimentary canal or the stomach. The liquid also quickly picks up heat, boils and becomes a gas, which could cause damage such as perforations or cause a stomach to burst,” he says.
Emsley asserted he would be surprised if someone could swallow liquid nitrogen. “It would be extremely cold in anyone’s mouth – people would want to spit it out immediately,” he says.
Emsley believes the liquid nitrogen is safe in the hands of chefs and bartenders trained to use it, he suggests that there should be a very strong warning not to “play” with it. “It can be a bit of a novelty in the hands of experts, but it would be a different territory in the hands of the general public.”
“If you put your finger in liquid nitrogen, it would go rock solid and fall off,” he says.
David Morris, Tory MP for Morecambe and Lunsdale, UK, has called for a ban on drinks made with liquid nitrogen following Scanlon’s ordeal. “I would like to see these drinks banned from sale so we do not see anyone else’s son or daughter injured or even killed.”
‘Barcode’ Blood Test Reads Genetic Results, Helps Detect Aggressive Prostate Cancer
Lawrence LeBlond for redOrbit.com – Your Universe Online
A blood test that can read genetic results much like a ℠barcode´ has been developed by scientists at the Institute of Cancer Research (ICR) and the Royal Marsden NHS Foundation. This genetic blood test can also detect the most aggressive prostate cancers by reading particular patterns of gene activity.
Research staff believe the test could eventually be used to select patients who are most in need of immediate treatment. Prostate cancer is a very diverse disease. Some people live with it for years without any symptoms, but in others, the disease can be very aggressive and life-threatening, said lead author of the study, Professor Johann de Bono, of ICR, and an honorary consultant at Royal Marsden.
Current cancer screening tests include a biopsy, where doctors take a small sample of a tumor and examine it under a microscope to find out how dangerous it may be. Experts hope that the new barcode test will ultimately lead to more accurate estimations without invasive biopsy screenings. The researchers also believe the barcode test could be used in conjunction with current PSA screenings to select patients who are in dire need of treatment.
Described in The Lancet Oncology medical journal, the test is unique because it can assess changes in the pattern of gene activity in blood cells triggered by a tumor found elsewhere in the body.
“We’ve shown it is possible to learn more about prostate cancers by the signs they leave in the blood, allowing us to develop a test that is potentially more accurate than those available now and easier for patients than taking a biopsy. Our test reads the pattern of genetic activity like a barcode, picking up signs that a patient is likely to have a more aggressive cancer. Doctors should then be able to adjust the treatment they give accordingly,” said de Bono.
In the trial, de Bono and colleagues scanned all the genes present in blood samples of 100 patients with prostate cancer at the Drug Development Unit in London and The Beatson West of Scotland Cancer Centre in Glasgow. The trial included 69 patients with advanced prostate cancer and 31 control patients with low-risk, early-stage cancer.
The team divided the patients into four groups reflecting their pattern of gene activity–the barcode. After reviewing all the patients´ progress over nearly 30 months, the researchers found patients in one group had survived for significantly less time than patients in others. Further modeling identified nine key active genes shared by all patients in the group.
The researchers then compared the results with another group of 70 US patients with advanced cancer. What they found is that these nine genes could be used to accurately identify those who survived for a shorter period–9.2 months compared with 21.6 months for patients without the gene pattern. The findings suggest a number of the genes actually suppressed the immune system in patients whose cancers were spreading.
“Whether particular genes are active or not is an important clue in identifying patients with a poor prognosis. This latest study shows that it is possible to read these patterns of gene activity like a barcode, allowing scientists to spot cancers that are likely to be more aggressive,” said Professor Alan Ashworth, chief executive of The Institute of Cancer Research.
“Personalized medicine is the future of cancer treatment. This blood test, which reads genetic changes in prostate cancer providing a prediction of how aggressive the cancer might be, is an important development, allowing us to better tailor treatment to suit each individual,” added Professor Martin Gore, medical director at The Royal Marsden.
“For years it has been extremely difficult to try to predict which men have very aggressive tumors and which do not,” noted Dr. Kate Holmes, head of research at Prostate Cancer UK. “We are therefore encouraged by news of research, part funded by Prostate Cancer UK, that may have taken a step towards finding a test that can finally draw this distinction.”
“If these early findings can be confirmed by much larger studies over time this method could potentially be used to help inform how aggressive a tumor will be and empower men and their clinicians to make much more informed decisions about which treatments are best for their individual circumstances,” Holmes said in a statement, reports Mail Online´s Jenny Hope.
“We look forward to seeing the results of further research and hope it confirms the findings hinted at today,” she said.
A similar six-gene prostate cancer blood test, currently being tested by researchers at the Dana-Faber Cancer Institute and the Memorial Sloan-Kettering Cancer Center, can split patients into high and low risk groups.
“These are important results,” Professor Malcolm Mason, of Cancer Research UK, said in an interview with BBC´s Michelle Roberts.
“Not only do they point to a group of patients with advanced prostate cancer who do particularly badly, and who therefore may need different forms of treatment, but they also point to the possible role of the immune system in influencing how a cancer might behave,” he said. “If the present results are borne out in further studies, we may have a new way of selecting the right treatments for the right patients.”
Prostate cancer is the most common male cancer in the UK, with more than 40,000 diagnoses every year. More than 10,000 men die from the disease each year as well.
The ICR/Royal Marsden study was funded by AstraZeneca, Prostate Cancer UK and the Prostate Cancer Foundation. The Drug Development Unit receives funding from Cancer Research UK and the Experimental Cancer Medicine Centre network.
Prescription Drugs: Still Potent Years After Expiration Date
Lawrence LeBlond for redOrbit.com – Your Universe Online
Every year millions of people are tossing out drugs that have reached or passed their expiration dates; many could be doing so because they believe such drugs are not as potent as they once were. However, a new analysis of eight prescription drugs that have well-surpassed their discard date, some by as much as 40 years, has found that these drugs are just as potent as the day they were manufactured.
Just as most consumers are curious as to whether these outdated drugs are safe, so were researchers from the California Poison Control System, UC San Francisco and UC Irvine. Armed with an array of eight drugs between 28 and 40 years past their prime, the researchers tested their effectiveness levels to see if they had in fact gone bad.
The drugs tested came from pharmacy shelves, many sitting around collecting dust for decades, and had remained sealed in their original containers.
The researchers focused their studies on 15 active ingredients found in the drugs, including acetaminophen, codeine, caffeine, hydrocodone, aspirin, amphetamine and others.
The researchers couldn´t find a standard test for one ingredient, homatropine, so they dropped that one from their analysis.
To test their potency levels, the researchers dissolved the drugs and subjected them to chemical analysis using a mass spectrometer, which revealed how much of the active ingredients remained in the pills. Out of the 14 tested ingredients, 12 were still at high enough concentrations (90 percent) to qualify as having “acceptable potency.”
The only two active ingredients that lost any significant amount of potency were aspirin and amphetamine. In the remaining 12, the potency levels fall within the range deemed acceptable by the Food and Drug Administration, which allows “reasonable variation” in the strength of prescription drugs, requiring that they contain generally between 90 and 110 percent of the stated active ingredient.
In most of these drugs, expiration dates are labeled to between one and five years after manufacture. However, the FDA does not mandate that drug companies must test how long their active ingredients will last and most expiration dates are set randomly and without any logic, said the researchers.
“All [the expiration date] means from the manufacturers’ standpoint is that they’re willing to guarantee the potency and efficacy for the drug for that long“¦It has nothing to do with the actual shelf life,” noted lead author Lee Cantrell, a professor of clinical pharmacy at the University of California, San Francisco.
The study results do not indicate the effectiveness of these eight drugs tested, but Cantrell said there is no reason to think otherwise. It is likely that many people are throwing out their outdated pills prematurely. And this could have important implications for drug shortages and health care costs.
“We’re spending billions and billions on medications and medication turnover,” Cantrell said. “If a drug has expired, you’ve got to throw it away, it goes into a landfill, and you have to get a new prescription. This could potentially have a significant impact on cost.”
And although there could be complications from taking medications with less potency, expired drugs are generally safe. As far as the researchers know, there is only one example of a drug becoming toxic after reaching its expiration date, and that was an isolated incident.
Surprisingly, three ingredients tested were found in amounts greater than 110 percent of label strength. The researchers noted that it is likely the drugs containing these ingredients were manufactured before quality-control regulations were introduced by the FDA in 1963.
The government´s Shelf-Life Extension Program allows drugs to be retained for up to 23 years (278 months) after they expire if tests show they remain potent. But Cantrell and colleagues found that some of the ingredients tested remained good for up to 40 years (480 months)–and who knows, they could even last longer.
Perhaps the most important implication of the study “involves the potential cost savings resulting from lengthier product expiration dating,” said the researchers. “Given that Americans currently spend more than $300 billion annually on prescription medications, extending drug expiration dates could yield enormous health care expenditure savings.”
However, Cantrell cautioned that people should not go digging through their trash to retrieve their discarded drugs just yet.
Some of the drugs tested in the latest analysis are no longer widely used, and it is not clear if these results carry over to other newer types of drugs on the market, or for similar drugs stored in different conditions, Mohammed Nutan, an associate professor of pharmaceutical sciences at the Texas A&M Health Science Center, in Kingsville, told Health.com´s Amanda Gardner, as reported by CNN.
The drugs in the study were unopened and still in their original containers. Those that have been opened and/or stored in inappropriate conditions may pose a significant health risk, Nutan warned. Humidity, temperature and light exposure can affect how long a drug remains potent, and perhaps its toxicity.
Despite this, Cantrell said his team´s findings indicate that expiration dates on at least some drugs could be safely extended. “Perhaps expiration dating of medications needs to be revisited,” he added.
The researchers reported their analysis findings in the online edition of the Archives of Internal Medicine.
Stiffness Could Be Possible Biomarker To Predict Metastatic Potential Of Ovarian Cancer Cells
Connie K. Ho for redOrbit.com — Your Universe Online
Researchers from Georgia Tech recently found that ovarian cancer cells that are highly metastatic are much softer than ovarian cancer cells that are less metastatic.
The findings on cell stiffness in relation to cancer cells were recently published in the academic journal PLoS ONE.
“In order to spread, metastatic cells must push themselves into the bloodstream. As a result, they must be highly deformable and softer,” explained Todd Sulchek, an assistant professor at the George W. Woodruff School of Mechanical Engineering, in a prepared statement. “Our results indicate that cell stiffness may be a useful biomarker to evaluate the relative metastatic potential of ovarian and perhaps other types of cancer cells.”
In the study, the researchers utilized atomic force microscopy (AFM) to help them better understand the mechanical properties of different ovarian cell lines. The stiffness of the cells could be measured with a mechanical probe. The findings of the study showed that cancerous ovarian cells are usually softer than cells that are non-malignant.
“This is a good example of the kinds of discoveries that only come about by integrating skills and knowledge from traditionally diverse fields such as molecular biology and bioengineering,” remarked John McDonald, the director of Georgia Tech´s Integrated Cancer Research Center whose lab worked with Sulchek´s lab in the study, in the statement. “Although there are a number of developing methodologies to identify circulating cancer cells in the blood and other body fluids, this technology offers the added potential to rapidly determine if these cells are highly metastatic or relatively benign.”
The team of investigators hopes to continue to develop the technology, so that it may help clinicians develop new cancer treatments. In particular, they believe it would be useful in creating chemotherapies that could be used by ovarian cancer patients as well as patients suffering from other forms of cancer.
According to the U.S. Centers for Disease Control and Prevention (CDC), out of all the cancers related to the female reproductive system, ovarian cancer causes the most deaths. In particular, older women are more susceptible to the disease. Approximately 90 percent of women who are diagnosed with the disease are older than 40 years of age.
To promote awareness of the illness, the CDC collaborated with the Department of Health and Human Services´ Office on Women Health to produce a national campaign. The campaign focuses on upping awareness and understanding of the five different gynecological cancers, including ovarian cancer. The Gynecological Cancer Education and Awareness Act that was enacted in 2005 also helps provide support for the project.
As well, the organization recommends that females be cognizant of signs and symptoms of ovarian cancer as it can be diagnosed in its early stages. Ovarian cancer can lead to vaginal bleeding or irregular discharge from the vagina. As well, females may suffer from back pain, pain in the abdominal or pelvic area, or bloating. There are no easy ways to screen for ovarian cancer, so medical professionals recommend that females consult a doctor if there are any noticeable changes in the body.
Ancient Spider Attack On Wasp Trapped In Amber
April Flowers for redOrbit.com – Your Universe Online
Researchers at Oregon State University have found an extraordinarily rare fossil. Trapped in amber is what the research team describes as the only example of a spider attack on prey caught in its web — a 100 million year old snapshot of an engagement frozen in time.
Found in the Hukawng Valley of Nyanmar, the fossil dates from the Cretaceous between 97 and 100 million years ago. Giving some evidence to oldest examples of spider social behavior, the amber contains not only the spider attacking the prey, but also another male spider in the same web. This behavior exists today, but is rare. Instead, most spiders live solitary, almost cannibalistic existences, and males will not hesitate to attack immature species in the same web.
“This juvenile spider was going to make a meal out of a tiny parasitic wasp, but never quite got to it,” said George Poinar, Jr., a professor emeritus of zoology at Oregon State University and world expert on insects trapped in amber.
“This was a male wasp that suddenly found itself trapped in a spider web,” Poinar said. “This was the wasp´s worst nightmare, and it never ended. The wasp was watching the spider just as it was about to be attacked, when tree resin flowed over and captured both of them.”
Researchers believe that spiders are ancient invertebrates that date back some 200 million years. The oldest fossil evidence found of a spider, however, is only about 130 million years old. This type of fossil, showing an attack between a spider and its prey has never been documented before.
Amber is made from a tree resin that is renowned for its ability to flow over insects, small plants and other life forms. This preserves them in near perfection before turning into a semi-precious stone. Amber often gives scientists their clearest look into the biology of the past. The spider in this sample, which may have been patiently waiting for hours to capture prey, was smothered in resin just a split second before its attack on the wasp.
The wasp in the fossil is of a type known today to parasitize spider and insect eggs, so the attack by the orb-weaver spider could be considered payback. Both spider and wasp belong to extinct genera. At least 15 strands of unbroken spider silk shoot through the amber.
The findings of this research have been published in the journal Historical Biology.
Public Health Needs ‘Superheroes’
Public health ‘superheroes’ are needed to help tackle the growing challenges posed by obesity, alcohol, smoking and other public health threats, according to new research published today.
The research, an international collaboration from the Universities of Leeds, Alberta and Wisconsin, calls for government and policy makers to recognize the role that public health leaders can play in addressing these significant health challenges.
It suggests that potential public health ‘superheroes’ can come from both within public health disciplines, and perhaps more importantly, from outside the profession. However, the research also questions the ability of current public health professionals to lead and influence policy. Instead, it voices concerns about the “corporatization” of public health in compromising leaders’ abilities to speak out as independent advocates for the health of the public.
The results are published today in the medical journal, Lancet.
One of the lead authors of the research, Professor Darren Shickle, head of the Academic Unit of Public Health at the University of Leeds, said: “Public health as a specialty has been stifled by re-organization and it is critical that both current and new professionals have help in becoming more effective leaders. You only have to look at the role that Jamie Oliver has played as someone who has the ability to engage, inspire and make a difference. But we need to act now to ensure public health leaders at all levels have the skills, resilience and influence to address the public health challenges of today and the future.”
World Health Organisation data reveals the extent of the challenge, indicating that that worldwide obesity has more than doubled since 1980 and that the harmful use of alcohol results in 2.5 million deaths each year. Tobacco kills nearly 6 million people each year and according to the Department of Health, smoking accounts for over 100,000 deaths every year in the UK alone.
Professor Tom Oliver, from the University of Wisconsin, added: “We must ensure that leaders across many sectors of society understand the causes and consequences of these major threats to health and well-being. More importantly, we must develop leaders who can translate that understanding into political support for evidence-based responses to those threats. The most effective leaders combine systematic analysis of problems and potential solutions, and have an ability to recruit partners and champions for new policies and practices.”
Across the UK, local governments are preparing to take on a wider remit for public health from April 2013, with new duties to improve the health of their communities. Professor Shickle believes this transference of public health functions to local authorities presents significant challenges but there are also opportunities for both developing current leaders and recruiting new ‘superheroes’.
He said: “The new public health system is moving forwards rapidly now, opening up doors to a growing number of effective leaders who can occupy key positions and intervene at all levels to bring about radical changes in social attitudes and behavior. Challenges posed by obesity and alcohol alone represent a ticking timebomb, with huge implications for health budgets, but effective public health leaders can play a central role in driving this change.”
Commenting on current levels of public health leadership training across the world, Professor Ken Zakariasen, from the University of Alberta, added: “Many public health leadership programs are responding with much more sophisticated training to prepare leaders. However, this research has identified that public health training varies internationally, and considerably more effort is required to develop the higher levels of leadership.”
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On the Net:
Autistic “Elopement” Is A Serious Concern For Parents And Caregivers
Michael Harper for redOrbit.com — Your Universe Online
According to a new study conducted by Dr. Paul A. Law, director of the Interactive Autism Network, nearly half of children diagnosed with an Autism spectrum disorder have run away at least once, either for short periods of time or longer, causing concern amongst their parents and researchers alike.
“I knew this was a problem, but I didn´t know just how significant a problem it was until I really began to look into it,” commented Dr. Law.
Throughout this study, Dr. Law and team found these children running away from home or school, with many running away more than once a day. The most troubling aspect of this research is what can happen to these children when they do wander off.
“This is probably one of the leading causes of death and morbidity for kids with autism,” said Dr. Law in an interview with the New York Times.
Referred to as wandering or elopement, this behavior has been shown to lead to tragic accidents among these children as they wander into traffic and, sometimes, into rivers or oceans.
This new study investigated over 1,200 families with Autistic children and found that 49% of children with autism spectrum disorder (ASD) attempted to “bolt” at least once after the age of 4. A majority of these wandering children, 53%, were missing long enough to cause concern.
“These are the first published findings in the US that provide an estimate of the number of children with ASD who not only wander or elope, but go missing long enough to cause real concern,” said Dr. Law.
Children who had disappeared long enough to be a cause of concern were labeled as “missing” in the report, while those who had run away for a shorter period of time were not coded in the same way.
After analyzing the data from these 1,200 families, Dr. Law´s team furthermore discovered that a shocking 74% of these children with ASD were wandering away from “safe” places, such as their own homes or homes of close family friends. When these children were out and about with their families on shopping trips, 40% of them had run away from these stores, leaving them in potentially unfamiliar territory. 29% of these children were reported as running away from their schools, as well.
The study also found that these children are more likely to run away at ages 4 and 5. When this behavior is at its peak, 29% of the interviewed parents said their children would try to elope several times a day. Another 35% of parents said their children would attempt to run away at least once a week.
“It´s rooted in the very nature of autism itself,” said Dr. Law in a Reuters report.
“Kids don´t have the social skills to check in with their parents, and to have that communication and social bond that most children have when they´re approaching a road or at a park.”
One-third of all elopement cases studied by Dr. Law and team required police intervention in order to recover these children. In many of the situations, these children were in danger of being hit by cars, causing traffic accidents or even drowning.
“There´s an enormous burden that all families are undergoing to keep their families safe,” concludes Dr. Law.
“The amount of diligence, and not going out in public, and staying up late at night“¦ just the general anxiety that families live under because of concerns with this is just torturous.”
While Dr. Law admits that further research needs to be conducted to determine any patterns in how and why these children run away, he also hopes this study will be enough to inform doctors, parents and even first-responders about the dangers of elopement.
“Parents often fear being viewed as neglectful when their children leave from safe places,” says Dr. Law.
“This study demonstrates that we urgently need interventions to address elopement and provide support to affected families.”
Dr. Law’s research is scheduled to be published in the journal Pediatrics.
Happy Birthday To The Barcode: 60 Years Of Scanning History
Lawrence LeBlond for redOrbit.com – Your Universe Online
Barcodes have been the mainstay of the consumer world for close to 40 years, first used on a food product in 1974 when Wrigley´s chewing gum received the first barcode (the predecessor to the Universal Product Code, or UPC). But the linear displays of bars and lines have been in use elsewhere since the early 1950s, initially as a code to label railroad cars.
The idea for a barcode was first conceived in 1948 by Bernard Silver, a graduate student at Drexel Institute of Technology in Philadelphia, after overhearing the president of a local food chain, Food Fair, inquiring about a system that could automatically read product information at the checkout line. Silver began working with colleague Norman Joseph Woodland.
After initial results proved futile, Drexel had stopped funding for the research. Woodland, refusing to give up, moved into his father´s apartment in Florida and continued working on the system, where he became inspired by the Morse Code system, and formed his first barcode on a sandy beach.
“I just extended the dots and dashes downwards and made narrow lines and wide lines out of them,” Woodland recently recalled.
To read this barcode, Woodland adapted technology from optical soundtracks used in movies, using a 500-watt light bulb shining through the paper onto an RCA935 photomultiplier tube from a movie projector on the far side. After fine-tuning their work, Woodland and Silver filed a patent in October 1949 for “Classifying Apparatus and Method.” The patent, spending nearly 3 years in the approval process, was issued on October 7, 1952.
Today, 60 years after the barcode was first patented, there are more than 5 million individual barcodes in use around the world, according to regulator GS1 UK. However, the barcode remained absent from food labels for the first 20+ years of existence because laser technology used to read them did not exist in the 50s.
The barcode is an optically-scannable representation of data that relates to a specific object to which it is attached. While it began showing up on food products in the mid 70s, it did not receive a universal welcome–wine manufacturers refused to use it on their labels for aesthetic reasons–taking away from the artistic appeal of bottle.
Recently, the linear barcode received a baby brother, the Quick Response (QR) Code. While the new and improved code, made up of dots, can contain far more information and data than the traditional barcode, it is unlikely to replace the barcode anytime soon.
“They have different purposes – the barcode on the side of a tin of beans is for point-of-sale scanning. It ensures the consumer is charged the right amount and updates stock records,” said Gary Lynch, chief executive of GS1 UK. “The QR code’s main purpose is to take the person that scans it to an extended multi media environment. Technically you can combine the two but nobody’s asking for that right now.”
The QR Code, which has become synonymous with mobile media, was invented in Japan in 1994 as a way to track vehicles during the manufacturing process.
Through the years, many different types of codes have been developed, but none as popular and well-known as the UPC barcode and quickly advancing QR code.
As for the barcode, it has become a pop culture icon of sorts. Nebraska artist Scott Blake has used barcodes to design detailed works of art, including a portrait of famous American artist Andy Warhol using more than 2,100 barcodes. The barcode has also shown up as body art, with US singer Pink sporting a barcode tattoo.
“Barcodes are an icon and rightly so – we’re quite pleased about it,” said Lynch. “But if one of my daughters had one in homage to her father I’d be rather upset.”
UK Officials: Fatal Crimean Congo Virus Unlikely To Spread
April Flowers for redOrbit.com — Your Universe Online
The UK’s first laboratory confirmed case of Crimean Congo Viral Hemorrhagic Fever (CCVHF) has died. Even so, health officials are stressing that this will not become a public outbreak. The Health Protection Agency is adamant the 38-year-old unnamed man poses no threat to others.
“It can be acquired from an infected patient, but this requires direct contact with their blood or body fluids. Therefore, there is no risk to the general population,” said a spokeswoman.
The patient was diagnosed after returning to Glasgow from Kabul, Afghanistan. His flight connected through Dubai.
He was originally being treated at Gartnavel General Hospital’s Browlee Center, which specializes in infectious disease, but was later flown to London’s Royal Free Hospital’s high-security infectious diseases unit. The Royal Free Hospital houses the national specialist center for the management of patients with hazardous infections.
Precautionary measures have been taken to contact the four passengers in most direct contact with the patient and two of them are under daily monitoring for the next two weeks — which is the incubation period for CCVHF. The other two passengers do not require monitoring and the risk to the rest of the flight is extremely low.
“The monitoring of these two passengers is purely precautionary and is in line the national guidance for the management of cases such as this.”
CCVHF is fatal in about 30% of human cases. It is a zoonosis, which is a disease that is common in animals but can transfer to humans. It is present in over 30 countries in Europe, Asia and Africa.
Onset of the disease is fast, with high fever, joint pain, stomach pain and vomiting. Red eyes, flushed face and red spots in the throat are also common symptoms. As the disease progresses, the patient can develop large areas of deep bruising, severe nosebleeds and uncontrolled bleeding.
Medicare Fraud Probe Leads To 91 Arrests In Seven Cities
redOrbit Staff & Wire Reports — Your Universe Online
A federal task force has arrested 91 people, including doctors, nurses, and other healthcare professionals, as part of a widespread Medicare fraud probe, various media outlets reported on Thursday.
According to Reuters reporters David Ingram and David Morgan, the accused hail from seven different U.S. cities and allegedly billed the nation’s senior-care health program for more than $430 million in false claims. It is the second such raid in the past six months, following a $450-plus million investigation back in May.
“Those charged included a group in Los Angeles that ferried patients for ambulance rides that were never medically necessary,” said Los Angeles Times reporter Richard A. Serrano.
Federal law enforcement officials said that 16 people, including a trio of doctors and a licensed physical therapist, were among those arrested, and that the schemes cost the government agency a combined $53.8 million.
Serrano added that a dermatologist and psychologist were arrested in Chicago, and that arrests were also made in Baton Rouge, Brooklyn, Dallas, Houston, and Miami. The Chicago charges stem from “unneeded laser treatments and psychotherapy services,” while the other indictments are linked to “more than $230 million in home healthcare fraud” and “more than $100 million in community healthcare schemes,” he added.
In addition, Reuters reported that 33 arrests took place in Miami, where the accused allegedly billed the government for home health services and mental health care that was not provided, and that officials had discovered $42 million worth of improper claims originating from Houston-based Riverside General Hospital. That facility had previously been charged with $116 million in fraud, Ingram and Morgan said.
Health and Human Services Secretary Kathleen Sebelius told BBC News that the arrests “put criminals on notice that we are cracking down hard on people who want to steal from Medicare.”
She added that in addition to the arrests, 30 other medical service providers had been suspended or subject to administrative action based on what the British news agency refers to as “credible allegations of fraud.” Reuters added that some of those arrested also will face identity theft and money laundering charges.
Healthy Mice Created From Skin Stem Cells In Lab
Lee Rannals for redOrbit.com — Your Universe Online
Japanese scientists reported in the journal Science that they have created life using stem cells made from skin.
The skin cells were used to create eggs which were then fertilized to produce baby mice, who later had their own babies.
The technique has implications that may possibly help infertile couples have children, and maybe could even allow women to overcome menopause.
About one in 10 women of childbearing age face trouble becoming a parent, according to the Centers for Disease Control and Prevention (CDC).
Last year, the scientists at Kyoto University were able to make viable sperm from stem cells. In the more recent study, the team was able to perform a similar accomplishment with eggs.
The researchers used two sources, including those collected from an embryo and skin-like cells, that were reprogrammed into becoming stem cells.
After turning the stem cells into early versions of eggs, they rebuilt an ovary by surrounding the early eggs with other types of supporting cells normally found in an ovary.
They used IVF techniques to collect the eggs, fertilize them with sperm from a male mouse and implant the fertilized egg into a surrogate mother.
The babies not only turned out to be healthy, they were also able to make their own offspring.
Although the implications provide potential relief for couples suffering from infertility, the system cannot be immediately adapted to human cells for both scientific and ethical reasons, according to Dr. Katsuhiko Hayashi from Kyoto University.
He told BBC that the level of understanding of human egg development is too limited and there would also be questions about the long-term consequences on the health of a child.
“It’s an absolutely brilliant paper – they made oocytes [eggs] from scratch and get live offspring. I just thought wow! The science is quite brilliant,” Dr. Evelyn Telfer, from the University of Edinburgh, said in a statement. “If you can show it works in human cells it is like the Holy Grail of reproductive biology.”
The Los Angeles Times reported that the research creates an opportunity for scientists to look at the genesis of the egg.
“How is the reserve established in the beginning? What contributes to some women having depleted reserves? How do cells make the choice to enter meiosis? There are hundreds of questions we can begin to answer,” UCLA stem cell scientist Amander Clark told the LA Times.
Professor Robert Norman from the University of Adelaide said the paper offers hope for parents who want a child genetically related to them and for women who want their own children but are well past menopause.
“Application to humans is still a long way off, but for the first time the goal appears to be in sight,” Norman said in a statement.
Dr. Allan Pacey from the British Fertility Society and the University of Sheffield said that what is remarkable about the research is that the offspring were both healthy and fertile.
“This is a great step forward, but I would urge caution as this is a laboratory study and we are still quite a long way from clinical trials taking place in humans,” Pacey said in a statement.
The researchers said in the journal that their study serves as a foundation to investigate and reconstitute female germ line development in vitro in mice as well as other mammals.
Free Birth Control Reduces Abortion Rates, But May Lead To More Sex
Lawrence LeBlond for redOrbit.com – Your Universe Online
A new study published online in Obstetrics & Gynecology shows that abortions and unplanned pregnancies have dramatically dropped after adult and teenage women were offered birth control at no cost. Women and girls were also more likely to choose IUDs or contraceptive implants when cost was not an issue.
Providing free birth control options substantially reduced the number of unplanned pregnancies and abortion rates by 62 to 78 percent over the national rate, according to the study from researchers at Washington University School of Medicine in St. Louis.
The study of St. Louis women and teen girls showed a dramatic drop over national unplanned pregnancy and abortion rates during the study period. Long-acting reversible contraceptive (LARC) offered free by the researchers led to four times fewer abortions than the regional rate, and five times fewer abortions than the national rate.
“The impact of providing no-cost birth control was far greater than we expected in terms of unintended pregnancies,” said Jeffrey Peipert, professor of Obstetrics and Gynecology at WU School of Medicine. “We think improving access to birth control, particularly IUDs and implants, coupled with education on the most effective methods has the potential to significantly decrease the number of unintended pregnancies and abortions in this country.”
Peipert and colleagues found that among the birth control methods offered in the study, most women chose long-acting methods like IUDs and implants, which have lower failure rates than commonly used birth control pills. In the US, IUDs and implants have steep up-front costs that most women cannot afford, as they are not covered under most health insurance plans.
Unintended pregnancies are a major problem in the US, accounting for roughly 50 percent of all pregnancies, far higher than in other developed countries. And nearly half of all unintended pregnancies come from incorrect use of contraception or no use at all.
“US taxpayers pay approximately $11 billion annually in costs associated with 1 million unintended births,” the researchers wrote.
Because of this burgeoning national epidemic, Peipert and colleagues designed the Contraceptive CHOICE Project “to promote the use of the most effective contraceptive methods (intrauterine devices [IUDs] and implants) and provide contraception at no cost to 10,000 female participants.” The free contraceptives were offered to women and teen girls in the St. Louis area who were at highest risk for unintended pregnancy.
Peipert and his team enrolled nearly 10,000 women and teens in the program between 2007 and 2011. Participants were between 14 and 45 years of age, at risk for an unintended pregnancy and willing to use contraceptives.
The researchers gave the participants their choice of birth control methods, which included the LARCs, pills, patches and rings. The participants were counseled about the effectiveness, risks and benefits of all forms, and after lectures were given, 75 percent of all participants chose the IUDs or implants.
During the study period, the team found lower abortion rates among CHOICE participants that were considerably less (4.4 to 7.5 per 1,000) than the rates for non-participants in St. Louis city and county, which ranged from 13.4 to 17 per 1,000 women, for the same years. The abortion rate of study participants was also far lower than the national rate of 19.6 per 1,000 women for the same years of the study.
For teen girls ages 15 to 19 who had access to the birth control provided in the study, annual birth rate was 6.3 per 1,000, more than five times lower than the national rate of 34.3 per 1,000.
“This study reinforces what I have seen in my own practice,” Yale School of Medicine ob-gyn Nancy Stanwood, MD, told WebMD´s Salynn Boyles. “When women have access to all methods of birth control and cost is not a barrier, they prefer the highly effective methods.”
Cost of IUDs and implants has been a significant deterrent for women and teens looking for birth control methods, but cost is not the only barrier for these women, noted Adam Sonfield, of the nonprofit reproductive health advocacy group Guttmacher Institute. Many health providers have opted to not offer these long-acting methods to teens in the past, because of potential side effects.
But times are changing, and a recent report by the US´s largest group of obstetricians and gynecologists published an opinion on the subject, concluding that IUDs and implants are both safe and appropriate methods of contraception for teens, said Sonfield.
He pointed out that the average age for starting sexual activity is about 17, and many women now want to delay having children until their late 20s. “The gap is close to 10 years, so it makes sense that women would want a long-acting birth control method that they don´t have to think about every day.”
The findings of Peipert´s study come as millions of US women are now beginning to get access to more contraceptive options without co-pays under President Barack Obama´s new Obamacare health care reform law.
Obamacare requires that Food and Drug Administration (FDA)-approved contraceptives be available for free to women enrolled in most workplace insurance plans. Most plans will take effect beginning on January 1, 2013.
The measure has sparked outrage from the U.S. Conference of Catholic Bishops and many other conservative groups, who state the law violates religious freedom by offering controversial birth control to employees of religious-affiliated organizations, such as colleges and hospitals. The law states that these organizations are not exempt from the law and must offer the plans. US Republican presidential nominee Mitt Romney has voiced similar criticism over the bill.
A St. Louis federal judge this week dismissed a possible lawsuit challenging the contraception mandate; just one of more than three dozen similar lawsuits that have been filed around the country.
Yet, the recent lawsuit dismissal is not deterring opponents of the measure.
Jeanne Monahan of the conservative Family Research Council suggested contraceptive use may actually encourage more teens to partake in risky sexual behavior.
“Additionally, one might conclude that the Obama administration’s contraception mandate may ultimately cause more unplanned pregnancies since it mandates that all health plans cover contraceptives, including those that the study’s authors claim are less effective,” Monahan said.
Nearly half of the country´s 6 million-plus pregnancies each year are unplanned, with an estimated 43 percent of those ending in abortion. Low income women are far more likely to have unplanned pregnancies than those who are wealthier.
Peipert said in the US there shouldn´t be a “tiered system where the women with money can get family planning and the women without cannot.” He noted that 39 percent of the women in his study had trouble just paying their basic expenses.
About half of the unintended pregnancies in the US occur in women who use no contraceptives; those who rely on condoms or other short-acting methods make up the other half.
But with LARCs, such as Implanon, an implant inserted under the skin of the arm, women can forget about unintended pregnancies for up to three years. And an IUD inserted into the uterus can last for five to ten years, depending on the brand. And theses devices can be removed at any time if the user has a change of heart.
But currently, in the US, only 5 percent of women use LARCs, far fewer than in most other developed countries. Insurance is the main thing holding women back here, said Peipert. Obamacare should change that.
Adult Cells In The Brain Used To Generate Neurons
[ Watch the Video: New Human Neurons from Adult Cells Right There in the Brain ]
Connie K. Ho for redOrbit.com — Your Universe Online
Difficulties in balance and movement, hesitation in breathing and talking are just a few of the detrimental effects of neurodegenerative disease, and the illness can sometimes be serious or even life threatening. In the research community, more studies are being done to understand how these disorders can be treated. In particular, a new study highlights how human neurons can be generated from adult cells in the brain. Researchers believe that the results of the study will help in developing cell-based therapies to treat neurodegenerative diseases like Alzheimer´s and Parkinson´s.
The team of scientists completed neuronal reprogramming of adult human brain pericytes by utilizing transcription factors Sox2 and Mash1. According to The Scientist, Sox2 was experimented on in mice to change a certain type of brain cells into neurons while Mash1 was used in changing skin cells into neurons. The study took place over a period of four to five weeks and the researchers documented the transformation of the cells with the help of a time-lapse video microscope.
“We believe that Mash1 and Sox2 superimpose a neuronal program onto a cell that has another program running,” Benedikt Berninger, lead author of the study, told The Scientist. “But we are keen to understand the exact mechanisms.”
Based on the results, the researchers found that the reprogramming of somatic cells into neurons could help develop cell-based therapy for neurodegenerative diseases. In particular, they found that cells from the cerebral cortex part of the brain could be reprogrammed into neuronal cells.
“This work aims at converting cells that are present throughout the brain but themselves are not nerve cells into neurons,” said Berninger, a researcher currently at the Johannes Gutenberg University Mainz, in a prepared statement. “The ultimate goal we have in mind is that this may one day enable us to induce such conversion within the brain itself and thus provide a novel strategy for repairing the injured or diseased brain.”
In particular, pericytes are the cells that were found to be able to move from one adult cell to human neuron. The cells, which are in close contact with blood vessels, help keep the blood-brain barrier together. Researchers also believe that the cells can be utilized in healing wounds in various parts of the body.
“Now, we reason, if we could target these cells and entice them to make nerve cells, we could take advantage of this injury response,” continued Berninger in the statement.
Additional testing also showed that the neurons that were converted to adult cells could start up electrical signals. These signals could connect to other neurons and showed that converted cells could be added to neural networks. The researchers plan to investigate the various components of programming and how they can make it become more effective.
“While much needs to be learnt about adapting a direct neuronal reprogramming strategy to meaningful repair in vivo, our data provide strong support for the notion that neuronal reprogramming of cells of pericytic origin within the damaged brain may become a viable approach to replace degenerated neurons,” concluded the researchers in the paper.
The findings were recently published in Cell Stem Cell, a Cell Press publication.
Subtropical Dry-Zone Is Expanding South
Lee Rannals for redOrbit.com — Your Universe Online
New research reported in the journal Scientific Reports claims that the southern hemisphere is becoming drier.
The researchers wrote that a decline in April-May rainfall over southeast Australia is associated with a southward expansion of the subtropical dry-zone.
The scientists were looking to explore why autumn rainfall has been in decline across southeastern Australia since the 1970s, which is a period that included the Millennium drought from 1997 to 2009.
Previous research pointed at a southward shift in the storm tracks and weather systems during the late 20th century. However, the extent to which these regional rainfall reductions are attributable to the pole-ward expansion of the subtropical dry-zone had not been clarified until now.
“There has been a southward expansion of the edge of the Hadley cell — also called subtropical dry-zone — over the past 30 years, with the strongest expansion occurring in mid-late autumn, or April to May, ranging from 200 to 400 kilometres,” Tim Cowan, a Commonwealth Scientific and Industrial Research Organization (CSIRO) scientist who worked on the project, said in a statement.
The team found the autumn southward expansion of the subtropical dry-zone is greatest over southeastern Australia, as well as over the Southern Ocean to the south of Africa.
“The Hadley cell is comprised of a number of individual branches, so the impact of a southward shift of the subtropical dry-zone on rainfall is not the same across the different semi-arid regions of the Southern Hemisphere,” CSIRO’s Dr. Wenju Cai said in the statement.
They tested the hypothesis that the dry-zone expansion would give rise to the southward shift in the average rainfall during April and May. They also questioned how rainfall might be affected across semi-rigid regions, including southern coastal Chile and southern Africa.
“During April and May, when the dry-zone expansion is strong, rainfall over south-eastern Africa, south-eastern Australia and southern-coastal Chile is higher than over regions immediately to their north,” Dr. Cai said.
The team found that for southeastern Australia, up to 85% of rainfall reduction can be accounted for by replacing southeastern Australian rainfall with rainfall 250 miles to the north. This southward shift of rainfall can explain only a small portion of the southern African rainfall trend.
“For south-east Australia, autumn is an important wetting season,” Dr. Cai said in a statement. “Good autumn rainfall wets the soil and effectively allows for vital runoff from follow-on winter and spring rain to flow into catchments.”
The study said an important issue remains as to why the poleward expansion is largest in the fall and there is still uncertainty about the role of external forces, like greenhouse gases.