Regular Screenings Could Eliminate Disparity In Breast Cancer Between White, Black Women

Regular mammography screening can help narrow the breast cancer gap between black and white women, according to a retrospective study published in Breast Cancer Research and Treatment in August.
Earlier studies have shown that black women in Chicago are more than twice as likely to die of breast cancer compared to white women. Black women with breast cancer reach the disease’s late stages more often than white women, and their tumors are more likely to be larger and more biologically aggressive.
But according to the study, when women of both races received regular breast cancer screening – a mammogram within two years of breast cancer diagnosis – there was no difference in the rate of how many of them presented in the disease’s later stages.
The data result from a retrospective study conducted of women diagnosed with breast cancer from January 2001 to December 2006 at Rush University Medical Center and Northwestern Memorial Hospital in Chicago. Data were collected on 1,642 subjects, including 980 who were regularly screened and 662 who were irregularly screened.
“This study reinforces the fact that racial gaps in breast cancer outcomes can be improved,” said lead author Dr. Paula Grabler, an assistant professor of radiology at Northwestern University Feinberg School of Medicine and a radiologist at Northwestern Memorial Hospital. “One solution within reach is simple access to routine and regular mammography screening.”
One notable finding was that women screened regularly, regardless of race, were more likely to have hormone receptor-positive breast cancers than those who did not receive regular screenings. Breast cancers that are hormone receptor-positive contain receptors for the hormones estrogen and progesterone, making them more responsive to hormone therapy such as tamoxifen or aromatase inhibitors and leads to a better survival. This finding was statistically significant in black women, suggesting that early detection can blunt the development of negative prognostic biological characteristics in some women.
“This suggests that poor prognostic biological factors such as receptor status and tumor grade, once thought to be innate and immutable, may be significantly ameliorated by regular mammography screening, especially in black women,” said Dr. David Ansell, the study’s senior author and chief medical officer at Rush University Medical Center. “This is a unique finding that will require further exploration.” Ansell is also chair of the Metropolitan Chicago Breast Cancer Task Force, which includes more than 100 organizations and more than 200 breast cancer experts. In October 2007, the task force released its first major report, “Improving Quality and Reducing Breast Cancer Mortality in Metropolitan Chicago,” with 37 recommendations for addressing racial disparities in breast cancer mortality.
In October 2009, the Task Force announced the creation of the Chicago Breast Cancer Quality Consortium. This became the nation’s first federally designated Patient Safety Organization dedicated solely to breast health. With the federal protections provided by this designation, 55 hospitals and the Chicago Department of Public Health signed up in 2009 to join the Chicago Breast Cancer Quality Consortium project and share quality data to identify deficits and implement strategies to improve breast cancer screening and treatment.

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New Comet Discovery May Be Brightest Visitor In Past Hundred Years

Lawrence LeBlond for redOrbit.com – Your Universe Online

Hale-Bopp, Haley´s, McNaught. These are just a few of the more well-known modern comets that have blazed across the night sky in our lifetime. Another comet that has been recently discovered could be added to that list next year when it makes a pass by the Sun in late 2013.

The comet, named C/2012 S1 (ISON), is due to come within 1.1 million miles of the Sun on, or around, November 29, 2013. Vitali Nevski and Artyom Novichonok from Russia, made the discovery using the International Scientific Optical Network´s (ISON) telescope, capturing the images of the comet on 21 September with CCD imagery equipment.

The comet could blaze brightly across the heavens when it does arrive, experts believe. But just how brightly is difficult to determine. And there could be a chance the Sun will just boil it away as it passes, just as happened to comet Elenin last year. If it does survive the encounter, experts speculate it could outshine any comet seen in the last hundred years–perhaps even brighter than the full moon. If so, it should be easily visible to the naked eye for about two months, and could even be visible during daylight.

If the predictions hold true, Comet C/2012 S1 will likely be one of the greatest comet encounters in human history, exceedingly outshining the memorable Hale-Bopp of 1997 and Haley´s Comet in 1986. It could even be a much bigger spectacle than the long-awaited Comet Pan-STARRS, which will make a pass in March 2013.

BRIGHTNESS

The only thing that is certain at this point, is that the large cometary body was discovered just beyond the orbit of Jupiter and it´s orbital trajectory will take it close to the sun next year. The comet is currently very faint, but as it approaches the Sun, it will steadily brighten. It will be easily picked up by experienced amateur astronomers with CCD equipment in the coming months, and will be within binocular view by late summer 2013, and eventually by the naked eye in early November. Depending on brightness, the comet should remain visible to the naked eye from early November 2013 to mid-January 2014

“In the best case, the comet is big, bright, and skirts the sun next November. It would be extremely bright — negative magnitudes maybe — and naked-eye visible for observers in the Northern Hemisphere for at least a couple of months,” Karl Battams, of the NASA-supported Sungrazer Comet Project, told Spaceweather.com.

However, this outcome is far from certain, noted Battams. “Alternately, comets can and often do fizzle out! Comet Elenin springs to mind as a recent example, but there are more famous examples of comets that got the astronomy community seriously worked up, only to fizzle,” he said.

Writing in a blog for the Planetary Society, astronomer Bill Gray pointed out that the comet´s orbit has been very well constrained, but just how bright it will be is anyone´s guess at the moment–“…estimating comet brightnesses a year ahead of time is about like asking who’s going to win the World Series next year.”

“It could be astonishingly bright, or it could fizzle. I think it was David Levy (co-discoverer of Comet Shoemaker—Levy 9) who said that comets are like cats: they have tails, and do whatever they want to do,” Gray remarked.

COMET ORIGINS

Comets originate from the outer limits of the solar system and are generally composed of icy volatiles such as water, carbon monoxide, carbon dioxide, methane and ammonia. These icy behemoths also contain dust, rocks and any other debris that just happen to be floating around when the Sun evolved. Researchers hypothesize that Comet C/2012 S1 originates from the Oort Cloud, a cloud of frozen comets located about one light year from the Sun possibly containing billions of cometary nuclei that formed during the early days of the solar system when the Sun formed.

“This is quite possibly a ‘new’ comet coming in from the Oort cloud, meaning this could be its first-ever encounter with the sun,” Battams pondered. “If so, with all those icy volatiles intact and never having been truly stressed (thermally and gravitationally), the comet could well disrupt and dissipate weeks or months before reaching the sun.”

As comets close in on the Sun, the increased solar energy puts stress on the celestial orbiter, causing its frozen volatiles to vaporize, bypassing the liquid phase altogether. Sublimation causes the comet´s gases to erupt, sweeping them back by the solar wind, which forms the tail, the common trait of the comet. Depending on the comet´s chemical elements, the journey past the Sun could make the tail spectacularly impressive.

Of course, this will be dependent on what the exact chemical makeup is and how it formed in deep space. And it is very likely the chemical elements may be just the right mixture that it will cause the comet to erupt, fracture and break apart long before it becomes visible to the naked eye. Or, it may whiz by and release very little material, fizzling any excitement of a spectacular showing.

SUNGRAZER

Due to the comet´s scheduled close inspection of our Sun, it will be, what experts call, a sungrazer. Sungrazers are comets that typically pass within a few million miles of the Sun, with some passing even within a few thousand miles. Famous examples of sungrazers are the Kreutz sungrazers and the Great Comets of 1843 and 1882, as well as the Comet Ikeya-Seki of 1965.

Despite the likelihood of breaking up under the increased solar output of the Sun, there remains a slight chance it could become the brightest comet to scream across the skies in the last hundred years–even brighter than Ikeya-Seki, which dazzled astronomers in 1965.

If it lives up to the hype, it will be far brighter than the last bright visitor, Comet McNaught, which gave earthlings in the Southern Hemisphere a good show in January 2007. But then again, it could peter out like Elenin did in 2011, or more famously, the comet Kohoutek, which failed to live up to predictions in 1973.

“This is a very exciting discovery. The comet looks like it could become a very spectacular sight in the evening sky after sunset from the UK in late November and early December next year,” Robin Scagell, vice-president of the Society for Popular Astronomy, told the Telegraph.

“Our members will be eagerly following it as it makes its first trip around the Sun and hoping to see it shining brilliantly and displaying a magnificent tail as it releases powerful jets of gas and dust,” he added.

DOOMSDAY

The debate over the brightness should not spill over into any concerns over the comet´s projected orbit. Doomsayers often get excited when new comets are discovered and start rumors of collision courses with the Earth, such as what happened with last year´s comet Elenin.

Comet C/2012 S1 will not even come remotely close to Earth. Even on its nearest approach in January 2014, it will be 36 million miles from Earth, according to comet hunters at Remanzacco Observatory in Italy.

Gray said the best bet is to just sit back, relax and enjoy the show. “I’d give it about a 30 percent chance of being exciting, with a 60 percent chance that I’m wrong. In other words, it’ll certainly bear keeping an eye on, but I don’t think anyone can say for sure right now.”

With Increasing Aging Population, Study Advises Policy Changes

Connie K. Ho for redOrbit.com — Your Universe Online
A study from the National Academies recently revealed that major policy changes are needed to deal with the aging population in the United States and the long-term impact that they will have on the economy.
Researchers noted that the economic consequences of the growing aging population will affect younger generations as well as the various federal programs that provide aid to the elderly. They believe that the increasing demographic shift to people over the age of 65 is not temporary and not related to only the baby boomer population; researchers note that the trend will continue to be seen in later decades. The National Academies is made up of members of the National Academy of Sciences, the National Academy of Engineering, the Institute of Medicine and the National Research Council.
“The bottom line is that the nation has many good options for responding to population aging,” remarked Roger Ferguson, a co-chair of the committee that completed the report, in a prepared statement. “Nonetheless, there is little doubt that there will need to be major changes in the structure of federal programs, particularly those for health. The transition to sustainable policies will be smoother and less costly if steps are taken sooner rather than later.”
The report also stated that programs like Medicare, Medicaid and Social Security are unsustainable with their current rate of expenditure. The total cost of the three programs is approximately 40 percent of all federal spending and 10 percent of the country´s gross domestic product. In the future, the researchers believe that there will be more beneficiaries of these programs due to the results of longer life expectancy and reduced birth rates. However, there will be significantly less workers who can contribute to the programs and support the expenditures in the next few decades. The increasing aging demographic along with the increases in health care costs will continue to elevate health care expenditures and require more of the national resources.
As such, the researchers recommend that policy makers consider how costs and policies can be adapted to consider future generations who will have to bear the burdens of these federal programs. A number of discussions have been initiated on the issue, but the results of these conversations are still unclear. The researchers believe that the response by the public will include more saving during working years, structural changes to programs that are publicly supported, and older retirement ages.
“The nation needs to rethink its outlook and policies on working and retirement,” explained committee co-chair Ronald Lee, who serves as a professor of demography and economics at the University of California, Berkeley, in the statement. “Although 65 has conventionally been considered a normal retirement age, it is an increasingly obsolete threshold for defining old age and for setting benefits for the elderly.”
In addition, the report advised workers to prepare for retirement by planning early and adjusting the way they save or spend money. They also advised individuals to learn how to have better money management. According to the researchers, one-fifth to two-thirds of the elderly currently have not saved enough for retirement and depend much on Medicare and Social Security.
“Population aging does not pose an insurmountable challenge provided that sensible policies are implemented with enough lead time to allow people, companies, and other institutions to respond,” continued Ferguson in the statement.
The issues of an increasing aging population are not only seen in the U.S., as other industrialized countries are grappling with the difficulties The report cautioned that, if the U.S. does not take action, the staggering costs of health care can have rippling effects around the world. Researchers from the National Research Council plan to conduct a follow-up study to analyze the long-term macroeconomic effects of the aging population and to provide assessments on various policy options.

Chicago’s Urban Coyotes Show A Strong Monogamous Bond With Their Partners

Brett Smith for redOrbit.com – Your Universe Online
Some women in a relationship may refer to their cheating male partners as dogs, but a new study shows that women may have to start calling their men who stray something else if they want to be more accurate.
Scientists at the Ohio State University studied urban coyotes living around Chicago and found them to be 100 percent faithful to their mating partner, according to a new study in the latest edition of the Journal of Mammalogy.
“I was surprised we didn´t find any cheating going on,” said study co-author Stan Gehrt, an ecologist at the university. “Even with all the opportunities for the coyotes to philander, they really don´t.”
“In contrast to studies of other presumably monogamous species that were later found to be cheating, such as arctic foxes and mountain bluebirds, we found incredible loyalty to partners in the study population,” he added.
For the study, the Ohio State scientists took genetic samples of 236 coyotes in the Chicago area over the course of six years. To collect their samples, the scientists tried to perform cruelty-free entrapment by using padded foothold traps or non-choking neck snares to catch the animals. However, some of the pups were dug from their dens and held by hand.
Small blood and tissue samples were taken from all the coyotes in the study. The adults were anesthetized during this time and were also equipped with radio-collars so that the scientists could track and record their movements. All coyotes were released at the same location where they were captured, according to the research team.
A genetic analysis that was performed of the blood and tissue sample showed no evidence of polygamy within the population and in addition to genetic testing, the researchers also studied the coyotes mating pairs´ habits. The animals were observed to maintain long-term monogamy that often lasted for more than one breeding season. Male individuals were seen guarding their partners from other male interlopers possibly looking to mate.
During the female´s estrus cycle, when she is most receptive to pregnancy, the mating pair “will spend all their time together – running, finding food, marking their territory. They´ll always be right at each other´s side.”
“We´ve been able to follow some of these alpha pairs through time, and we´ve had some of them stay together for up to 10 years,” Gehrt said.
These results run contrary to the habits of many sexually reproducing animals, including humans. However, Gehrt said the monogamy makes sense for females that are capable of producing and overwhelming number of pups.
“If the female were to try to raise those large litters by herself, she wouldn´t be able to do it,” said Gehrt. “But the male spends just as much time helping to raise those pups as the female does.”
The finding came as part of a wider study that has been focused on studying the urbanized doggies since 2000. The research team plans to gain a better understanding of how the coyotes adapt to urban life while maintaining relatively little contact with people.

Common Mapping Software May Help Forensic Scientists Solve Crimes

redOrbit Staff & Wire Reports – Your Universe Online
Researchers at the Ohio State University have used a common, commercially available type of mapping software to determine whether patterns of change inside the bones of human remains could reveal how the bones were used during life.
The research, which was published in the American Journal of Physical Anthropology, could provide forensic scientists with a new tool to help identify bodies and solve crimes.
“Our bones adapt to the load that´s placed on them. Patterns of tension and compression show up in our internal bone structure, and this software lets us look at those patterns in a new way,” said lead researcher David Rose, a Captain in the Ohio State University Police Division and doctoral student in anthropology.
Rose and colleagues used a geographic information system (GIS) software program known as ArcGIS to study features inside a human foot bone.
Although the software has been used in the past to help map the location of objects uncovered at an excavation site — and Rose has even used the same program to map line-of-site views to develop security plans for campus events — the current study is the first time anyone has used GIS software to map bone microstructure.
Co-author Sam Stout, professor of anthropology at Ohio State and Rose´s advisor, explained why the study of internal bone structure is important.
“Dave’s work allows us to visualize, analyze, and compare the distribution of microscopic features that reflect the development and maintenance of bones, which we can relate to skeletal health and disease — for example, bone fragility in osteoporosis,” he said.
Other applications exist in forensics, Rose said, due to one gruesome fact: when unidentified human remains are discovered, the foot bones are often intact, having been protected by the deceased person´s shoes.
Any information about the person, such as age, sex, or body size, could ultimately help law enforcement in identifying a body.
In the current study, the researchers studied the cross-section of a metatarsal — a long bone in the foot — from a deceased woman who had donated her body to the Division of Anatomy´s Body Donation Program.
Using the bone cross-section, Rose and colleagues demonstrated how the GIS software could be used to show the loads experienced in the foot during gait.
The researchers recorded an extremely high-resolution image of the bone cross-section under a microscope, and used the software to map the location of structures known as osteons.
Osteons are microscopic structures created throughout life to repair small cracks in bones, or to maintain mineral levels in our blood.
The size and shape of the osteons, and the direction of the collagen fibers from which they are made inside bone, are influenced by the loads placed on bones during life.
In this case, the donor´s metatarsal bone showed the predicted pattern of normal bone remodeling, with concentrations of particular types of osteons along the top and bottom of the bone. These osteons could have been formed, for example, by forces the donor experienced while walking. In fact, they were precisely where researchers would expect to see telltale signs of foot flexure and compression.
Rose cautioned that the study serves only as a proof of concept, and that many more bones would need to be studied before GIS software could provide meaningful insight into bone biology.
“Really, we´re just combining very basic principles in GIS and skeletal biology,” he said.
“But I believe that there is a tremendous opportunity for advancements at the intersection of both disciplines. The real advantage to this method is that it offers a new scale for the study of human variation offering to shed light on how we adapt to our surroundings.”
Image 2 (below): This polarized microscope image shows a cross-section of a metatarsal, or long foot bone. White spots on the periphery of the bone are osteons — structures that fix small cracks in bone and maintain mineral levels in our blood. Image by David Rose.

Malicious Code In NFC And QR Wipes Out Samsung Smartphones

Lee Rannals for redOrbit.com — Your Universe Online

It seems like science fiction, but a single line of code could be able to completely wipe a Samsung device, restoring it back to factory settings.

The malicious code has been reported to reset Samsung devices such as the Galaxy S3, S2, Beam, S Advanced and Ace.

The code could be encoded in NFC tags or QR codes, leaving Samsung users to unknowingly wipe their devices as soon as their phone receives it.

Once the code has set in, users can only sit and watch as their phone starts the resetting process.

So far, the malicious code has remained just a legend, but it could only be a matter of time before someone decides to abuse it.

Ravi Borgaonkar, a security researcher, first reported the vulnerability at the Ekoparty security conference.

During the conference, he showed how a hacker could direct the user to a webpage where the code could push their phone back to its original settings. Borgaonkar said basically anything that could open a URL could be used to exploit the flaw found in the devices.

His demonstration showed how an attacker could just send an SMS to a device in order to receive a URL link to the malicious code. Once a link had been clicked to view the “sexy co-ed,” the phone displayed a screen showing the reset taking place.

Attackers could even use the code to kill a device’s SIM card. This, too, would be able to wipe a device in a matter of minutes.

Samsung smartphones running Touchwiz are the ones that appear to be affected. For now, a way to protect your phone from the malicious code is to turn off automatic page loading in your NFC and QR code reading apps. Also, as always, be extra cautious of any links you might click on that look suspicious.

MySpace Hopes Justin Timberlake Will Bring Users Back

Michael Harper for redOrbit.com — Your Universe Online

Hey look! MySpace is once again making headlines as it rides the coattails of Justin Timberlake´s fame!

Undergoing its 4th major redesign, MySpace continues to try and compete in a largely three-player industry. Once the top of the charts, MySpace earned its popularity in the early and mid-2000s based on music, helping many small bands gain a larger audience than they could have reached otherwise. In the promotional video announcing the new launch, it appears as if the social networking site wants to keep this part of their heritage alive.

With a clean design and horizontal scrolling, the new MySpace focuses heavily on sharing music and playlists with one another, as well as posting the usual digital detritus: Photos, stories, videos, etc.

In a bit of an ironic move, users will be able to merge their Facebook and Twitter accounts with the new MySpace, bringing over their existing photos and videos to the new “community.”

This is a nice move, of course, allowing these new users (or more likely, new-old users) to hit the ground running so to say, allowing them to immediately begin interacting with the new site, as opposed to spending their first few precious minutes trying to set up their new profile.

“We’re hard at work building the new MySpace, entirely from scratch,” reads the text at the MySpace introductory page, where users can request an invite to either rejoin or take a look at the new refresh.

“But we’re staying true to our roots in one important way – empowering people to express themselves however they want.”

Music will continue to have a strong presence on the site, as users will be able to share mixes, playlists and radio stations. In addition to letting users share their music, the new MySpace will also allow bands the ability to share their music with their fans in a new way. Artists Pages on the newly redesigned site will give artists the chance to show off their latest tracks and albums, as well as recent photographs, music videos and other appearances around the web. In the Timberlake-heavy introductory video (which was announced by Timberlake himself last night, via Twitter), an artist (assumed to be Timberlake) takes a turn through his artist profile, sending messages to his fans as well as showing off the way albums and feeds will look within the pages. Based on the video, it also appears as if artists will be able to take a look at their demographics, such as what percentage of their fans are male or female, where these fans live, and how many of them are talking about their music. It even looks as if artists will be able to send out messages to select groups of fans, as the video shows an artist (again, probably Timberlake) sending out a message made out to “Top Fans.”

Such functionality would be helpful for artists who want to effectively target their audiences rather than sending out blanket messages. For instance, sending out a message about an upcoming show in Denver means little to nothing for fans in Massachusetts. However, being able to send the same message to only those fans in the Colorado area makes the message a powerful one. MySpace was sold to Specific Media in 2011 at a huge loss to 2005 buyers, News Corp. New owners Specific Media, along with creative consultant Timberlake, now aim to make MySpace the place for music and the music community. According to media and music analyst Mark Mulligan, this rebranding is the “deepest” attempted by the failing social service yet.

Speaking to the BBC, Mulligan said of the new efforts, “It has to offer artists a reason why they would go there rather than on Facebook. It needs to become a social platform for bands and not just an alternative to Facebook.”

According to ComScore, MySpace only has an audience of 54 million. By comparison, Facebook had 150 million in May, down by 8 million from earlier in the year.

Now all that´s left to be seen is if anyone will choose to either switch or adopt a new social network, even if it is fronted by an ex-N*Sync member.

Zombie Bees Spotted Hundreds Of Miles From First Observed Location

Brett Smith for redOrbit.com – Your Universe Online

As the nights grow longer and Halloween draws closer, the walking dead aren´t the only horror lurking just outside the front door. Americans from coast to coast should be aware that sightings of the flying dead are on the rise as well.

More specifically, ℠zombie bees´ have now been spotted in Washington State, hundreds of miles from their first sighting in 2008 by a San Francisco State University biologist. These undead insects fly and behave in an erratic behavior, then drop dead after being infected by a parasitic fly that injects its eggs into the bee´s abdomen.

Seattle resident and amateur beekeeper Mark Hohn first noticed something unusual when he saw dead bees scattered around the front of his shop. Having heard about the zombie bee phenomenon, Hohn collected several of the tiny corpses in a plastic bag.

Hohn´s suspicions were realized when he saw that pupae had emerged from the honeybees´ bodies several days later.

“I joke with my kids that the zombie apocalypse is starting at my house,” said Hohn.

In addition to erratic flying patterns, infected bees have been spotted congregating around lights at night, which is unusual for most honey bees that typically spend the night inside their hive.

John Hafernik, who first discovered the phenomenon, has been tracking the dead and dying honey bees through a website called ZomBee Watch. The website is intended to determine where the parasite is actively infecting bees, record observations on how bees are behaving, and raise awareness of a serious problem that could be affecting the very pollinators that the agricultural industry depends on.

“We really would like to get more samples from Washington and from all over,” Hafernik told the Seattle Times.

The parasitic fly´s life cycle is literally ripped from the script of the sci-fi horror film “Aliens.” Adult female individuals will land on the back of a honey bee and inject their eggs into the bee´s body. The eggs eventually hatch and the maggots eat their way out of the insect until they burst out from the inside.

The maggots then become pupae with a hard, brown rice-like outer shell. Adult flies then emerge from the pupae in three to four weeks.

Like the aliens in the movie, it´s the parasitic flies that are the natives of the area and the hosts that are the intruders. Honey bees were brought to North America by European settlers in the 17th century. Before that time, the flies likely infected bumble bees and wasps.

The emergence of zombie bees has increased significance because of the recent massive drop in honey bee populations. While it appears unlikely that the parasites are a major driver of these die-offs, they could be part of a confluence of factors plaguing North American bees.

“It may occur a lot more widely than we think,” said chairman of the entomology department at Washington State University, Steve Sheppard, about the parasitic infections.

Sheppard and other experts agree that commercial pesticides, viruses, and mites all likely contribute to the phenomenon known as Colony Collapse Disorder.

Financial Burdens Reduce With Treatment For Families Who Deal With Alcohol Addiction

The financial effects of alcoholism on the family members of addicts can be massive, but little is known about whether treatment for alcoholism reduces that financial burden. A study of 48 German families published online today in the journal Addiction reveals that after twelve months of treatment, family costs directly related to a family member’s alcoholism decreased from an average of 676.44 (£529.91, US$832.26) per month to an average of 145.40 (£113.90, $178.89) per month. Put another way, average costs attributable to alcoholism decreased from 20.2% to 4.3% of the total pre-tax family income.

Among those 48 families, two of the largest family expenditures directly related to alcoholism were for alcoholic beverages (averaging 252.13/£197.51/$310.29 per month) and cigarettes (averaging 92.98/£72.83/$114.43 per month). Twelve months into treatment, those costs had reduced to 70.63 (£55.32, $86.92) and 64.21 (£50.29, $79.04) per month.

Also, after twelve months of treatment, the average amount of time spent caring for the affected family member dropped from 32.2 hours per month to 8.2 hours per month. Using the minimum wage in Germany for employees in the nursing industry (8.50 per hour), informal care provided by family members initially piled on an additional financial burden of 274.30 (£214.87, $337.66) per month, which reduced to 69.79 (£54.67, $85.88) per month after one year of treatment.

Even in cases of relapse, treatment for alcoholism still reduced the financial burden on families, but only by 65.22 (£51.09, $80.26) per month on average.

Lead author Dr. Salize (Central Institute of Mental Health, Mannheim, Germany) says, “We’re opening up an area of addiction research that doesn’t receive much attention. When they look at effects on families, addiction studies mainly focus on problems such as domestic violence and depression, not on the financial burden of caring for an alcoholic. But when health services and policymakers study the costs and benefits of treating alcoholism, they need to know that treatment has an immense financial effect not just on the alcoholic but also on his or her spouse, partner, children, and parents. The benefits of treatment reach well beyond the individual patient.”

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Salmonella Fears Prompt Additional Peanut Butter Recalls

Michael Harper for redOrbit.com — Your Universe Online

What started as a Salmonella outbreak related to peanut butter sold at Trader Joe´s has now expanded to include even more products sold in other locations, such as Target and even some online retailers.

According to the Associated Press, Trader Joe´s recalled its brand of peanut butter yesterday after it was found to be linked to 29 salmonella cases in 18 states across America.

Labeled as Creamy Salted Valencia Peanut Butter, the Food and Drug Administration (FDA) as well as the Centers for Disease Control said last weekend that this product was very likely the source of a recent outbreak.

This morning the recalls have spread as New Mexico-based Sunland Inc., which produces the Valencia Peanut Butter in question, has recalled an additional 76 types of their almond and peanut butter from stores all over the country.

Though each of those with documented cases of salmonella said they purchased their peanut butter from Trader Joe´s, Sunland sells their products under a variety of names in larger stores such as Target. Therefore, the New Mexico company is executing these recalls in cooperation with the FDA in the name of safety. In addition to almond and peanut butter, Sunland Inc is also recalling its cashew butter, roasted blanched peanut butter and Tahini, or sesame butter.

According to the Sunland statement, the recall is limited to products which were manufactured between May 1, 2012 and September 24th, 2012. The company initiated this recall when they had discovered that those 29 people had reported cases of salmonella in Washington, California, Arizona, Texas, Louisiana, Missouri, Illinois, Minnesota, Michigan, Pennsylvania, Massachusetts, New York, Rhode Island, North Carolina, Virginia, Connecticut, New Jersey and Maryland. Trader Joe´s Valencia Peanut Butter was produced on some of the same equipment as the other products being recalled today.

“There is nothing more important to us than the health and safety of our customers, particularly the many families who enjoy our peanut butter everyday,” said president and CEO of Sunland Inc, Jimmie Shearer.

“If you purchased these products, do not eat them. Please return the product to your supermarket for a full refund or dispose of it.”

These Sunland products are also sold under the following names:

– Archer Farms (Target´s brand name)
– fresh & easy
– heinen´s
– Joseph´s
– Natural Value
– Naturally More
– Open Nature
– Peanut Power
– Serious Food
– Sprouts

No other Sunland product is being recalled in this matter.

Trader Joe´s initiated their recall last Saturday “out of an abundance of caution.”

In their public statement, a Trader Joe´s spokesperson said, “We have no confirmed information that suggests this peanut butter is unsafe to eat, but there is nothing more important to us than the health and safety of our customers and crew, and the quality of our products. As such, if you purchased this product, please do not eat it. We encourage you to return the product to any Trader Joe´s for a full refund or dispose of it. We apologize for any inconvenience.”

Salmonella is most dangerous to younger children and senior citizens.

Those healthy individuals who contract salmonella can experience fever, nausea, diarrhea, vomiting and other forms of digestive distress.

Common Human Viruses Could Lead To Acne Cure

Lawrence LeBlond for redOrbit.com – Your Universe Online

Acne, Propionibacterium acnes, is a common human skin disease that affects hundreds of millions of people every year. It is also the bane of teenagers, causing insecurity and disrupting social life for many. But there may be new hope for pimple poppers everywhere. A new study suggests viruses could be used to treat acne, and effectively kill acne-causing bacteria.

By utilizing a harmless virus that lives on the skin, scientists say it could potentially pave the way for a breakthrough in viral products that treat the condition that is most commonly associated with adolescence.

Researchers, led by Dr. Graham Hatfull, of the University of Pittsburgh, have identified, isolated and studied the genomes of 11 viruses (phage) that can infect the acne-causing bacteria and destroy it. Hatfull and colleagues, including those from UCLA, plan to study these viruses further and see if they can harness them as a therapy for skin treatment.

“Acne affects millions of people, yet we have few treatments that are both safe and effective,” said principal investigator Dr. Robert Modlin, chief of dermatology and professor of microbiology, immunology and molecular genetics at the David Geffen School of Medicine at UCLA. “Harnessing a virus that naturally preys on the bacteria that causes pimples could offer a promising new tool against the physical and emotional scars of severe acne.”

“There are two fairly obvious potential directions that could exploit this kind of research,” said Hatfull. “The first is the possibility of using the phages directly as a therapy for acne. The second is the opportunity to use phage-derived components for their activities.”

P. acnes is a typical bacteria found on human skin, but it spreads widely during puberty, drawing out an inflammatory response that can lead to acne breakouts. Although there are effective treatments already on the market for treating the often embarrassing condition, antibiotic-resistant strains of P. acnes have emerged, highlighting the necessity for new and improved treatments.

To find an improved therapy, Pittsburgh and UCLA researchers enlisted volunteers with and without acne, isolated the phages and acnes bacteria from them, and then sequenced the genomes of the viruses. Surprisingly, the 11 phages discovered were remarkably similar, sharing more than 85 percent of their DNA, an unheard of level of similarity among viruses. The lack of genetic diversity suggests that resistance to viral therapies would be less likely to occur, the researchers said.

“Our findings provide valuable insights into acne and the bacterium that causes it,” noted Hatfull, who is Eberly Family Professor of Biotechnology at Pitt´s Howard Hughes Medical Institute (HHMI). “The lack of genetic diversity among the phages that attack the acne bacterium implies that viral-based strategies may help control this distressing skin disorder.”

Acne affects nearly 90 percent of Americans at some point in their lives, typically during adolescence, when hormones from puberty are on the rise. Yet scientists know little else about what truly causes the disorder and have only made limited progress in developing new therapies to battle the disease.

The most common, and most effective tools for fighting acne–benzoyl peroxide, antibiotics and Accutane–have been around for decades and have not been vastly improved upon.

“Antibiotics such as tetracycline are so widely used that many acne strains have developed resistance, and drugs like Accutane, while effective, can produce risky side effects, limiting their use,” explained study coauthor Dr. Jenny Kim, director of the UCLA Clinic for Acne, Rosacea and Aesthetics. “Acne can dramatically disfigure people and undermine their self-esteem, especially in teens. We can change patients’ lives with treatment. It’s time we identified a new way to safely treat the common disorder.”

The researchers noted that all of the phages identified carry a gene that makes the protein endolysin, an enzyme that is thought to break down bacterial cell walls and kill the bacteria.

Hatfull said enzymes like this one are used in other applications, which suggests that endolysin from these phages might also be useful as a topical anti-acne treatment. “This work has given us very useful information about the diversity of that set of enzymes and helps pave the way for thinking about potential applications,” he noted.

Future research will explore how these phages might be used therapeutically, but also how they can be used to manipulate the bacteria they infect, said Hatfull.

“This news is very exciting. Acne is a common condition that affects up to eight in 10 individuals [aged] between 11 and 30 in the UK, and at present there is no ‘cure’ for the skin disease,” Hermione Lawson, of the British Skin Foundation, told BBC News. “We understand how distressing the symptoms of acne can be for its sufferers and welcome any developments that can lead to a cure or at least a better understanding of the disease.”

The study is published today in the American Society for Microbiology´s journal mBio.

The study was supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health in Bethesda, Maryland.

NASA Pitches Proposal For New Space Station Orbiting The Moon

April Flowers for redOrbit.com – Your Universe Online
In an Orlando Sentinel exclusive report, NASA has announced their bid in the race to become the next major mission into space: the construction of an outpost that would send astronauts further into space than any other space mission in history.
The new “gateway spacecraft” would be in orbit on the far side of the moon to support a small astronaut crew. It would serve as a staging area for future missions to the moon and Mars.
The International Space Station orbits at just over 200 miles above the Earth. The new outpost would be 277,000 miles from Earth, making it far more remote and raising complex questions of how to protect the astronauts from deep space radiation and how to rescue them in the event of an emergency.
The White House was briefed earlier this month by NASA chief Charlie Borden on the proposal’s details, but as of right now it is unclear whether or not the idea has support from the administration. The price tag might be a deciding factor, as it would run into the billions of dollars.
NASA wants to build the small outpost using parts left over from the $100-billion International Space Station (ISS) at what is known as the Earth-Moon Lagrange Point 2. The Lagrange Point is a spot about 38,000 miles from the moon and 277,000 miles from Earth. That location allows the combined gravities of the Earth and the moon to reach equilibrium, making it possible to keep the station in place with minimal energy expenditure.
To reach that point, NASA plans to use the massive rocket and space capsule that is currently being developed as a replacement for the shuttle program. A first flight of the new rocket is planned for 2017, which would allow construction of the outpost to begin two years later.
The Space Launch System, or SLS, is designed to carry the Orion Multi-Purpose Crew Vehicle, which can transport a crew on missions to the moon or beyond. It will also carry important cargo, equipment and experiments to Earth’s orbit. The SLS will be the first exploration-class vehicle since the Saturn V took Astronauts to the moon over 40 years ago.
Potential missions that are being planned to utilize the outpost include the study of nearby asteroids, or robotic trips to the moon to retrieve moon rocks that would be studied by the astronauts at the outpost.  It could also lay the groundwork for more ambitious trips to Mars’ moons and even Mars itself, which lies about 140 million miles away.
NASA states that placing a “spacecraft at the Earth-Moon Lagrange point beyond the moon as a test area for human access to deep space is the best near-term option to develop required flight experience and mitigate risk.”
The outpost is set to solve several problems for NASA and will provide a definite purpose for the Orion space capsule and the Space Launch System rocket, which are currently being developed at the cost of about $3 billion annually. It will also involve NASA’s international partners, using Russian-built modules and other components from Italy. Finally, the outpost would represent “one small step” towards NASA’s ultimate goal of putting human footprints on Mars.
The budget still remains a problem, and federal spending is being slashed across numerous government projects and departments in the name of deficit reduction.  At the moment, it seems highly unlikely that NASA will get more than its current annual budget of $17.7 billion, if it receives even that much.
NASA insists that the outpost will be possible with only modest increases in their current allowance as long as they are able to avoid the types of overbudgeted projects that have plagued many of their recent endeavors.  For the time being, however, the outpost and its missions are officially listed as “unfunded” in the space agency´s ledger.
“There are many options — and many routes — being discussed on our way to the Red Planet,” said NASA spokesman David Weaver. “In addition to the moon and an asteroid, other options may be considered as we look for ways to buy down risk – and make it easier – to get to Mars.”
The concern over astronaut safety is paramount as well. The trip to the outpost would be days long, and since this is the farthest NASA has flown since the moon missions of 40 years ago, rescue and supply missions would become difficult. It remains unclear whether the astronauts would be permanently stationed or only be at the outpost part of the time.
The physiological effects of deep-space radiation on the astronauts are also a concern as the outpost would be more vulnerable than previous missions because it would be beyond the protective shield of Earth’s magnetic field.
“It is significantly more difficult to shield and protect their [astronauts’] health” at that location, said Jeff Chancellor, a National Space Biomedical Research Institute (NSBRI) scientist.
NASA acknowledges that an outpost mission would require a “culture change” to include the “acceptance of risk significantly different” from previous missions, including the shuttle program and its losses of two crews.
The space agency also still has the option of focusing on their human spaceflight program, which has languished in recent years. The Constellation program, which was to return astronauts to the moon by 2020, was cancelled by the current administration for being behind schedule and over budget.

Eye Proteins Proved Effective In Fighting Pathogens

Connie K. Ho for redOrbit.com — Your Universe Online

Researchers from the University of California, Berkeley recently discovered that fragments of keratin protein in the eye have the power to prevent pathogens and could possibly be used to develop new antimicrobial drugs.

In the study, the group of vision scientists tested synthetic versions of the keratin fragments against pathogens. They discovered that the synthetic fragments were able to eliminate the bacteria that could have otherwise caused cystic fibrosis lung infections, staph infections, strep throat, and diarrhea. The results of the study will be published in the upcoming October issue of the Journal of Clinical Investigation.

“What´s really exciting is that the keratins in our study are already in the body, so we know that they are not toxic, and that they are biocompatible,” remarked the study´s principal investigator Suzanne Fleiszig, a professor at UC Berkeley´s School of Optometry who studies infectious diseases and microbiology, in a prepared statement. “The problem with small, naturally occurring, antimicrobial molecules identified in previous research is that they were either toxic or easily inactivated by concentrations of salt that are normally found in our bodies.”

Based on the findings, the researchers believe that the keratin fragment could be produced and utilized as therapeutics for a low cost. The proteins included in the study were taken from cytokeratin 6A, a filament protein that links together to produce a mesh layer throughout the cytoplasm of epithelial cells. The scientists in Fleiszig´s lab worked to understand how the eye can be successful against infections and discovered the benefits of cytokeratin 6A. In particular, they found that the surface of the eye does not have bacteria residing on top of it and, through various label culture experiments, corneal tissue proved strong to enough to kill other pathogens.

“We used to think that cytokeratins were primarily structural proteins, but our study shows that these fragments of keratin also have microbe-fighting capabilities,” noted study lead author Connie Tam, an assistant research scientist in Fleiszig´s lab, in the statement. “Cytokeratin 6A can be found in the epithelial cells of the human cornea as well as in skin, hair and nails. These are all areas of the body that are constantly exposed to microbes, so it makes sense that they would be part of the body´s defense.”

The tests of fragments from cytokeratin 6A also showed that the molecules could rapidly eliminate bacteria that were in water and in a saline solution. The saline solution proved that the keratin fragments could even withstand human tears that contained salt. Other experiments completed by the team of investigators highlighted how cytokeratin 6A fragments could limit bacteria from targeting epithelial cells, while the proteins could allow the bacterial membranes to leak and eliminate the pathogens quickly.

“It is very difficult to infect the cornea of a healthy eye,” continued Fleiszig in the statement. “We´ve even used tissue paper to damage the eye´s surface cells and then plastered them with bacteria, and still had trouble getting bacteria to enter the cornea. So we proposed that maybe there were antimicrobial factors that are unique to the eye.”

Following the current study, the researchers hope to pursue further research to determine different keratin fragments in the body that acts as defense mechanism.

“Keratins may represent a novel class of antimicrobials with the potential to be designed to selectively kill specific pathogens,” concluded Tam in the statement.

Link Between Coronal Mass Ejections And The Sun’s Interior Motion

April Flowers for redOrbit.com – Your Universe Online
After forty long years of debates and theories and counter-theories, the community of solar physics scientists has still failed to come to a consensus about what causes the sun’s powerful coronal mass ejections (CMEs). CMEs have profound “space weather” effects on land based power grids and satellites in near-Earth geospace.
An international team of scientists explains the mysterious physical mechanisms behind the origin of CMEs in a study published in Nature Physics. The results, based on computer simulations, expose the intricate connections between CMEs and motions in the sun’s interior. This new data could lead to better forecasting of hazardous space weather conditions.
Clouds of magnetic fields and plasma — a hot gas composed of charged particles — comprise CMEs. The most powerful and fastest of these events explode from the sun at more than a million miles per hour, with an energy release more powerful than the entire worldwide stockpile of nuclear weapons.
“By studying CMEs we learn not only about the drivers of space weather but also about the structure of the atmosphere of the sun and other sun-like stars,” says lead author Ilia Roussev of the Yunnan Astronomical Observatory, Chinese Academy of Sciences (CAS) and the Institute for Astronomy at the University of Hawaii at Manoa.
Disruptions in power grids, satellites that operate GPS or telecommunication systems, pose threats to astronauts in space, cause spectacular auroras, and lead to the rerouting of flights over the polar regions are all effects of geomagnetic storms caused by CMEs. These storms happen when a solar eruption hits Earth’s protective magnetic bubble, or magnetosphere.
The study provides an explanation of the origin of these super speed ejections of magnetized plasma and the associated X-ray emissions, demonstrating a fundamental connection between the magnetic processes of the sun’s interior and the formation of CMEs.
“Through this type of computer modeling we are able to understand how invisible bundles of magnetic field rise from under the surface of the sun into interplanetary space and propagate towards Earth with potentially damaging results”, says SSC researcher Noé Lugaz of the UNH Institute for the Study of Earth, Oceans, and Space. He adds, “These fundamental phenomena cannot be observed even with the most advanced instruments on board NASA satellites but they can be revealed by numerical simulations.”
Accurate forecasting of solar eruptions and being able to predict their impact on Earth has long been a goal of solar physicists.
“The model described here enables us not only to capture the magnetic evolution of the CME, but also to calculate the increased X-ray flux directly, which is a significant advantage over the existing models,” asserts the authors.

Qatari Man Transported To UK Hospital After Diagnosis Of SARS-Like Illness

Lawrence LeBlond for redOrbit.com – Your Universe Online

A respiratory illness similar to SARS virus has been found in a patient from Qatar. The 49-year-old man, who was transferred to a London hospital by air ambulance from Qatar, is the second person confirmed with the coronavirus, according to the World Health Organization (WHO).

The UN health body said it urgently needs more information on the new virus, which comes from the same family as the SARS virus that emerged in 2002-03 and killed more than 800 people in China before being contained. The scope of the latest threat is still under investigation by health officials, who have said it is too early to recommend travel restrictions.

Peter Openshaw, director of the Centre for Respiratory Infection at Imperial College London, said it was unlikely, however, that there would be any widespread health concerns, but health experts will continue to be on alert and watch for any signs of it spreading.

The WHO said the patient was showing signs of an acute respiratory infection and kidney failure.

“The patient is still alive but, as we understand, in critical condition,” Gregory Hartl, spokesman for the Geneva-based WHO, told Reuters℠ Kate Kelland. “We are still investigating this. We’re asking for information from whoever might have seen such cases, but as of the moment we haven’t had any more notifications of cases.”

“In the light of the severity of the illness that has been identified in the two confirmed cases, immediate steps have been taken to ensure that people who have been in contact with the UK case have not been infected, and there is no evidence to suggest that they have,” said Professor John Watson, head of the respiratory diseases department at the UK’s Health Protection Agency (HPA).

“Further information about these cases is being developed for healthcare workers in the UK, as well as advice to help maintain increased vigilance for this virus,” he added.

The WHO said the Qatari man had gone to the doctor on September 3, suffering from the symptoms of an acute respiratory infection. On September 7, he was admitted to an intensive care unit in Doha, Qatar and on September 11, he was transferred to Britain by air.

While the WHO did not reveal why the man had been moved to the UK, it did note that the HPA did conduct lab tests and “has confirmed the presence of a novel coronavirus.”

It said the HPA compared gene sequences of the virus from the Qatari patient with samples of virus sequenced by Dutch scientists from lung tissue of a fatal case earlier this year in a Saudi Arabian national and found a 99.5 percent match.

Openshaw said while the two sequences appeared to be a match, there was little evidence that both the Qatari patient and the Saudi death are related. However, any new evidence of “sustained human-to-human transmission or of contact would be more worrying, raising the worry that another SARS-like agent could be emerging,” he noted.

SARS, like other coronaviruses, is spread through droplets of fluids–typically produced from sneezes and coughs.

Iran Blocks Google, Moves Forward With Domestic Network Plans

redOrbit Staff & Wire Reports – Your Universe Online

Iran moved forward with their previously discussed plans for a domestic version of the Internet over the weekend, as government officials announced that Google would be one of the first websites to be filtered through their state-controlled information network.

According to Reuters, officials are claiming that the country’s self-contained version of the World Wide Web, which was first announced last week, is part of an initiative to improve cyber security. However, it will reportedly also give the country the ability to better control the type of information that users can access online.

The first move in that direction came Sunday night, as a government deputy minister identified only as Khoramabadi announced that the Google search engine, as well as their Gmail online email service, would be blocked “within a few hours” and would remain filtered “throughout the country until further notice.”.

Reuters said that there were unconfirmed reports by the Iranian Students’ News Agency (ISNA) that the ban was connected to an anti-Islamic video posted on Google’s YouTube video sharing website. That video has led to widespread protests and violence throughout the Middle East, including attacks resulting in the deaths of a US ambassador and three other Americans in Libya earlier this month.

CNET‘s Michelle Meyers also reported Sunday that Iranian officials had confirmed that government agencies had already been connected to the “national information network,” and that a deputy minister said that the next step would likely be to connect the population en masse to the filtered Internet.

That revelation is “in line with a report from April that the country was planning a national intranet within five months in an effort to create ‘a clean Internet,” Meyers said. “That report was later denied, but reports of an Iranian Internet system isolated from the Web have continued to surface. Iranian media say the domestic system would be fully implemented by March 2013,” she continued, adding that it was “still unclear whether access to the World Wide Web would be cut once the Iranian system is rolled out.”

As of Sunday night, Google had yet to respond to Meyers’ request for comment.

“The idea of a self-contained Internet isn´t a new one in the Middle-Eastern country, as Iran has been contemplating such a network for nearly 10 years now,” redOrbit.com’s own Michael Harper said on Friday. “Though such a move could prevent further attacks on the country, the cost to build out this network could be a hefty one. In addition to building out the infrastructure and laying the groundwork for this massive project, the country would also have to devise and then pay for a security system to ensure these attackers aren´t allowed access.”

Bad Back? Better Check Your Genes

April Flowers for redOrbit.com — Your Universe Online

Most of us suffer from lower back pain at some point in our lives. Good posture and sitting up straight might help, but depending on your genes, they may not.

A new study, published in the Annals of Rheumatic Diseases, says that your genes, specifically the Park2 gene, play a key role in lumber disc degeneration (LDD). LDD has long been thought to be the number one cause of chronic back pain.

With LDD, the discs in your back, which cushion the vertebrae, become dehydrated and end up being squashed and bulging out over the years while bony growths called osteophytes can emerge from the spinal column. Both situations are thought to cause back pain.

This new study has found that serious LDD is inherited in 65% to 80% of cases.

“The impact of hereditary factors on LDD is remarkably high. In the 70s and 80s the Scandinavians spent millions looking for all the occupations which caused back pain, but they couldn´t find them,” said Dr Frances Williams, from the Department of Twin Research and Genetic Epidemiology at King´s College London.

Studies of identical twins that went into disparate professions, such as a truck driver and a PE teacher, showed both ended up with similarly bad lumbar disk degeneration later in life.

Dr. Williams and her team suggest that the main variation is caused by genetic factors. They discovered variants in the Park2 gene by looking for signs of LDD in the back scans of 4,600 people, and then searching their entire genomes for clues.

They believe that this discovery could lead to new treatments, however, the relationship between physical degeneration and chronic back pain is complicated.

Professor Alan Silman, medical director at Arthritis Research UK, said, “Lumbar disc degeneration is a common cause of lower back pain, and it’s known that up to 80% of cases have a genetic basis, but this is the first time a gene has been identified as linked to this often painful and disabling condition.

According to Dr. Williams, “Everyone gets LDD at some point, it’s like going grey.  But not everyone gets back pain.”

“We know that people whose discs wear out are at increased risk of episodes of lower back pain, but normal human discs are hard to get hold of to study so until now our knowledge of normal human biology was incomplete.

“Further work by disc researchers to define the role of the PARK2 gene will, we hope, shed light on one of most important causes of lower back pain.”

Even though people with serious physical degeneration are more likely to get chronic back pain, lots of people whose LDD looks really bad actually feel fine.

Dr. Adam Al-Kashi, of the charity Backcare, says that chronic back pain is not merely the result of physical damage. Rather, psychology is also important, and people who had a positive outlook were less likely to suffer.

“We are discovering that pain is an abhorrent response of the central nervous system, which is controlled by the mind,” he said.

Most people, even doctors, assume that chronic pain is permanent — and the best one can do is manage it. However, recent work suggests otherwise.

“We are finding we can reprogram the software – the brain – to overcome chronic pain,” he said.

Dr. Al-Kashi argues that studies that attempt to reduce illnesses to genetics wrongly make people feel helpless, as if there is nothing they can do.

Genetic studies do not reveal the whole picture, Dr. Williams says. People should still take care of their general health to minimize the chance of back pain, especially avoiding smoking and gaining a lot of weight.

She added: “Sitting up straight and exercising won’t change the way your discs change, but they might help you develop good muscular strength to keep a pain-free spine and back.”

“We have little control over the genes we are born with, but we can manage how we support our backs in other ways, such as exercise. This can prevent an existing condition from getting worse or delay the onset of a hereditary one. The majority of people should be using exercise and a healthy lifestyle to protect their backs against future injury, states Steve Tolan, advisor at the Chartered Society of Physiotherapy.

“To use an analogy, it doesn´t matter what type of car you have, you still need to keep the engine maintained.”

WHO On Doping In Sports: Now A Public Health Matter

April Flowers for redOrbit.com — Your Universe Online

The use of performance enhancing drugs, or doping, is a public health issue, not a sporting problem, as had been previously thought.

“If we believe that around 3% of high school boys in the U.S. are taking a steroid or growth hormone, then that’s a public health issue,” said Dr. Timothy Armstrong of the World Health Organization (WHO).

“Substance abuse in any shape or form has a physical and mental health aspect to it. The WHO, being the lead UN (United Nations) agency on health matters, takes this issue quite seriously.”

Armstrong made his report at a conference organized by the Arne Ljungqvist Foundation. The foundation is named for the Swedish anti-doping official who is also chairman of the International Olympic Committee (IOC) medical commission.

Ljungqvist agrees with Armstrong, “This is a first attempt to highlight this matter as a public health issue, which in my view it is.”

“Elite sport plays an obvious role. They are the role models of youngsters and if they are drug takers, that is not the right role model for the coming society. I am so happy today to see these international authorities coming together and sharing these concerns that are being expressed and I hope that we can find common ways to deal with them,” he added.

The World Anti-Doping Agency (WADA) Director General David Howman believes that what happens in elite sport has an effect on wider society and information sharing is crucial to attacking the problem. He states that in the last ten years it has become clear that there is a trickle-down effect into recreational sports and the high school arena.

“In Australia now, the customs people share their information with the Australian Sports Anti-Doping Agency (ASADA), and already 40% of their anti-doping rule violations come from that sort of information. That’s a very good example of how it can work when people work together.”

Howman continued by saying that the UK Anti-doping Agency has a similar arrangement with customs and police, who were providing information to the IOC. The anti-doping program that ran during the London Games was based on the intelligence garnered this way.

“My understanding is that it led to several cases that were discovered in the out-of-competition phase.”

Dr. Armstrong agrees that such cooperation between authorities and the anti-doping organizations is essential.  He also said that more data is needed to assess the full scale of the problem.

“Each of our organizations has a piece of the pie and can only work in the areas where we have a mandate to work. But we can join with our sister agencies such as UNESCO and other potential partners such as WADA and the IOC.

“We all require better data to inform prevalence – how many people are taking what substances and the adverse social and health effects as a consequence of that.”

One problem with anti-doping campaigns is, although almost every major sports organization has rules about doping, they aren’t consistent. An allegation of doping can ruin an athlete´s career and reputation.

For example, just two short weeks after the London Games ended, Lance Armstrong gave up his fight against the U.S. Anti-Doping Agency. The agency had accused Armstrong, seven-time winner of the Tour de France, of using performance-enhancing drugs. In August 2012, they stripped him of his titles and banned him from cycling, all without conclusive proof that he has used the drugs.

Armstrong isn’t the only pro-athlete to fall to doubt and allegation, as competitors in a wide range of sports and leagues undergo regular and surprise testing. Some of this testing is in accordance with WADA and some is not.

There are 258 prohibited substances on the WADA list, comprising six categories — non-approved agents, anabolic agents, peptide hormones, growth factors and related substances, beta-2 agonists, hormone and metabolic modulators, and diuretics and masking agents. These categories are completely banned and other substances are only banned for in-competition or certain sports.

Lots of sports organizations and leagues are not signatories with WADA, and so are not governed by their drug testing methods or penalties. For example, in Canada, the National Hockey League, Western Hockey League, Major League Soccer, Canadian Football League, Major League Baseball (Northwest League short-season Single-A in Vancouver) and Canadian Inter-university Sport all base their testing and prohibited substances on the WADA list, but are not governed by the agency.

WADA cites the sheer number of nations that won medals at the London Games shows that efforts to stop doping are working.

Howman stated that anti-doping campaigns allowed “clean” countries like New Zealand to win medals “because it actually gets rid of the cheats who might have otherwise precluded countries like New Zealand from getting them.”

“If you look at the other podium finishes from London you will find a far greater spread of countries than you would have in 1984, 1980, 1976, and I think that’s a really strong indication that anti-doping has had an impact,” Howman said.

How Technology Is Helping People To Get And Stay Healthy

redOrbit Staff & Wire Reports — Your Universe Online
Technology is often blamed for making those using it less healthy, but an increasing number of people are relying on apps and gadgets to monitor their well-being, according to recent media reports.
For example, 63-year-old Larry Smarr of La Jolla, California uses a device known as FitBit, which serves as a pedometer while also tracking his caloric intake, as well as a Zeo, which monitors and graphs the different phases of his sleep cycle and then sends the information to his smartphone, according to CNN’s Elizabeth Landau.
In addition, there are mobile apps that help Smarr and other health-conscious techies keep track of their heart rate, pulse and even their emotional well-being, the CNN reporter said. In all, such advances demonstrate how exercise and electronics, computing and conditioning, are increasingly becoming intertwined.
“A diet and fitness tracking app called SparkPeople has helped Michelle Jackson, 39, lose 102 pounds since March 2011,” Landau said. “Jackson uses the app to schedule all meals she plans to eat for the next week, starting with Sunday, but can make adjustments if plans change. The app suggests the calories, fat, protein and carbs to eat daily, and also helps her track the number of calories she burns as she records fitness activities.”
Other apps are helping those with serious health conditions, such as Type 1 diabetes, manage those diseases, explained Sheryl Ubelacker, a reporter with The Canadian Press. Such was the case with Sara Nita, who was looking for a way to electronically monitor and track trends with her diabetic son Marcus’s blood glucose levels when she discovered Bant.
“I wanted something that I could view on my phone when he’s away at school and the teacher calls and says: ‘Do you remember what he was, whenever?’ So I just wanted to have a log of it, instead of carrying a paper copy here and there and everywhere,” Nita told Ubelacker. “I really like it because it shows ups and downs, and the way you can tell if he’s starting to decline, maybe he might need a little less insulin or a little more, depending on his history in the last couple of days“¦ When he realizes his trends, he can say … maybe I should talk to Mom about maybe changing my insulin dose, maybe calling the doctor to get an adjustment.'”
“The Bant is just one medical-related app under development by the University Health Network in Toronto,” Ubelacker said. “Nita is using the public version of Bant, but UHN hopes to have a more advanced adaptation that automatically reads the data from a glucometer — the device that takes blood-sugar readings from a skin prick — available for free download soon.”
As Hitesh Raj Bhagat and Karan Bajaj of The Economic Times pointed out in an August article, though, it isn’t just smartphone apps that have become available for tech-savvy individuals interested in using that know-how to keep track of their own wellbeing. From scales that use Wi-Fi networks to upload data to an online account so that an individual can track his or her progress, to a pedometer that uses games to encourage people to participate in fitness activities, it can be easy to “use technology to plan and achieve your fitness goals.”

Medical Marijuana Supporters, Opponents Using Science To Argue Their Cases

redOrbit Staff & Wire Reports — Your Universe Online

As voters in the states of Washington, Colorado and Oregon consider whether or not to legalize marijuana use for medical purposes, both supporters and opponents of the proposition are turning to scientific evidence in order to make their case, according to recently published media reports.

In Colorado, those opposing legalizing pot point to a study completed last month by researchers at Duke University and King’s College London, Keith Coffman and Alex Dobuzinskis of Reuters wrote on Saturday.

In that study, the researchers followed 1,000 residents of New Zealand for multiple decades and determined that chronic use of the drug resulted in an average decrease of eight points in a person’s IQ score.

However, Mason Tvert, co-director of the Campaign to Regulate Marijuana Like Alcohol — an organization working in favor of legalization efforts in Colorado — countered by citing a recent Centers for Disease Control and Prevention (CDC) survey which showed that the creation of a state agency to oversee medicinal use of the substance resulted in fewer teens illegally using the drug.

That CDC survey, Tvert told Reuters, saw the percentage of teen pot users in Colorado fall from 25% in 2009 to 22% in 2011, even though the national average increased during that time span. Opponents deny his claims, Coffman and Dobuzinskis said, stating that there is no evidence to support that assertion.

“The claim that legalization and tight regulation will mean that youth will use less is bogus, because we don’t have the experiment,” Rosalie Pacula, co-director of the RAND Drug Policy Research Center, told Reuters, adding that legalizing the substance in Colorado would itself be like conducting such an experiment. “We don’t know definitively that legalization will increase youth use. I can tell you from the research I’ve done, it supports such a conclusion.”

“Marijuana is the most commonly used illicit drug in the United States,” claim Coffman and Dobuzinskis. “Teens are increasingly turning to it, and last year pot overtook cigarettes in popularity with 6.6% of 12th-graders using it daily, according to the University of Michigan Monitoring the Future Survey.”

Colorado, along with Washington and Oregon, will vote on the issue on November 6. If approved, the measures would permit the sale of pot to anyone over the age of 21 at specialized locations. To date, 17 states have approved the use of marijuana for medicinal purposes, according to Reuters.

Study Claims Teenagers Learn Distracted Driving Habits From Mom And Dad

redOrbit Staff & Wire Reports — Your Universe Online
Parents, if your teenage children are distracted drivers or engage in dangerous activities while behind the wheel of the family car, a new study suggests that you may be the one to blame.
According to CNN’s Todd Sperry, a survey of over 1,700 teens admitted that they had performed such risky activities as speeding, talking or texting on their cell phones, or not wearing their seat belts while operating a motor vehicle.
The survey, which was conducted by Liberty Mutual Insurance and Students Against Destructive Decisions (SADD), also found that more than half of those teenage drivers had observed their parents engaging in similar behaviors while driving.
“These findings highlight the need for parents to realize how their teens perceive their actions,” Dave Melton, a driving safety expert with Liberty Mutual, told Sperry. “Your kids are always observing the decisions you make behind the wheel, and in fact have likely been doing so since they were big enough to see over the dashboard.”
“You may think you only occasionally read a text at a stop light or take the odd thirty-second phone call, but kids are seeing that in a different way,” he added. “Answering your phone once while driving, even if only for a few seconds, legitimizes the action for your children and they will, in turn, see that as acceptable behavior.”
Speeding was the most frequently performed driving activity, with 94% of teenage drivers admitting that they had done so and 88% claiming that they had witnessed their parents surpassing the speed limit, The Car Connection Contributing Writer Suzanne Kate reported on Friday. Ninety-one percent of teens said they had witnessed their parents talking on a cell phone while driving, and 90% said they had done so as well, she added.
More than three-fourths of all teenage responders (78%) confessed that they had texted while driving, while 59% of parents reportedly had done so, according to the survey. Adults were more likely than their children to not wear seatbelts (47% to 33%) and drive under the influence of alcohol (20% to 15%), but teenagers were more likely than their parents to attempt to operate a motor vehicle after smoking pot (16% to 7%), Kate noted.
“The best teacher for a teen driver is a good parental role model,” Stephen Wallace, SADD’s senior advisor for policy, research and education, told the automotive website. “But parents have to demonstrate good driving behavior from the onset so new drivers understand that safe driving rules apply to everyone equally.”

Researchers Discover Unusual Symbiosis In Marine Microbes

April Flowers for redOrbit.com – Your Universe Online

A study published in this week’s issue of Science shows how tiny, single-celled algae and a highly specialized bacteria have formed a partnership that helps keep the ocean fertilized.  This symbiotic pair takes nitrogen from the atmosphere and “fixes” it into a form that other organisms can use.

The results of the study emerged from the investigation of a mysterious nitrogen-fixing microbe that has a very small genome.  Jonathan Zehr, a marine scientist at UC Santa Cruz (UCSC), first detected the marine microbe in 1998, but it now appears to be the most widespread nitrogen-fixing organism in the oceans.

The project was a collaboration between scientists from UCSC´s Institute of Marine Sciences, the University of Hawaii, the Max Planck Institute for Marine Microbiology, the Station Biologique de Roscoff, the National Science Foundation and the Pierre and Marie Curie University.

Even though the microbe belongs to a group of photosynthetic bacteria known as cyanobacteria, it lacks the genes that are needed to actually carry out photosynthesis. This is where the relationship with the algae comes in.

“The cyanobacterium is a nitrogen-fixer, so it provides nitrogen to the host cell [the algae], and the host cell provides needed carbon to the cyanobacterium, which is lacking the machinery to get its own,” explained Anne Thompson, a researcher at UCSC.

The symbiosis between these two microorganisms has been undiscovered until this time, according to Matt Kane, program director in the National Science Foundation’s (NSF) Division of Environmental Biology.

“Genomic analysis indicates that the partnership between these organisms in some ways models the one that led to the evolution of plant organelles,” says Kane.

From an evolutionary perspective, the team says that this is an interesting symbiosis, “because it can be seen as analogous to an early stage in the endosymbiosis that led to chloroplasts in plants.”

Endosymbiosis is a process whereby chloroplasts, which carry out photosynthesis in all plants, evolved from symbiotic cyanobacteria that were eventually incorporated into host cells.

Previously, Zehr and his team studied the cyanobacteria in samples that were processed at sea and brought back to the lab. Although the team was able to sequence the microbe’s complete genome and discover that it was missing the genes for several key metabolic pathways, they were only able to see the symbiotic relationship when they sorted freshly collected seawater samples onboard a research vessel.

“Our collaborators at the University of Hawaii, Dave Karl and Ken Doggett, put a cell sorter into a portable laboratory — a lab in a box — so now we can take the machine to sea and sort cells that minutes before were in their natural environment,” says Thompson. “That’s how we found the association.”

The researchers admit that it is difficult, at this point, to estimate the contribution of this symbiosis to the global carbon cycle.  There are other algae in more abundance which may be more important in terms of the ocean’s carbon cycle.  But, according to Zehr, the cyanobacteria partners likely make this a significant contribution to global nitrogen fixation in the oceans.

“Planktonic symbioses are very difficult to study,” says Foster. “The associations are often fragile.  Here we used multiple tools to identify one of the first examples of this kind of partnership in plankton.”

IUDs, Implants Urged For Teen Girls’ Birth Control

April Flowers for redOrbit.com — Your Universe Online

The American College of Obsetricians and Gynecologists (ACOG) recently updated its guidelines for teen birth control, recommending that teens use IUD’s and hormonal implants as a “first line of defense.”

Both IUD’s and hormonal implants, like the Implanon device, are long lasting and more effective birth control than the pill or the patch, the group says. However, they are more invasive, requiring a doctor to put them in place. They are also more expensive, which is probably why the pill is still the most popular form of contraception in the U.S.

The downside to birth control pills is that they must be taken every day, at the same time. Even one forgotten pill can lead to pregnancy, given that the pill only has a 91% effectiveness rating.

An IUD, or intrauterine device, can last between five and ten years, preventing unwanted pregnancy. It is a small, T-shaped plastic device which is inserted in the uterus and utilizes either hormones or copper. Conversely, the implant generally lasts about three years and is a small plastic rod-shaped cylinder that is inserted under the skin of the arm to release the hormone progestin.

The guidelines do not suggest that teens only use the IUD or implant because they will not prevent STI’s or HIV, but “if your goal is to prevent a pregnancy, then using an implant or an IUD would be the best way to do this,” said Dr. Tina Raine-Bennett, head of the committee that wrote the recommendations.

The previous guidelines, released in 2007, also recommended IUD’s and implants for teens, however the new guidelines go further in stating that doctors should discuss these types of birth control at every visit with sexually active teens.

The latest statistics show that between 33% and 43% of girls ages 15 to 19 have had sex, and most are using some form of effective birth control but only about 5% have used the long-lasting devices. According to the CDC’s National Center for Health Statistics, most probably don´t even know about these methods.

According to ACOG’s research, over 80% of teen pregnancy is unintended. Teens are generally using the shorter-term methods of contraception, which have higher failure rates often due to incorrect usage. Teens are also more likely to stop using the shorter-term contraceptive methods.

“This recommendation is timely and essential,” says Dr. Ellen Rome, head of the Center for Adolescent Medicine at Cleveland Clinic Children’s Hospital. “Long-acting reversible contraceptive methods are twice as effective as shorter acting contraceptive methods at reducing teen pregnancy and could make a significant impact in preventing the 750,000 teen pregnancies occurring annually in the United States alone.”

The Guttmacher Institute tracks laws affecting women’s health and they report that in 21 states, all teenagers can get contraceptives without parental consent. A few other states allow it under certain circumstances.

The IUD and implants can cost hundreds of dollars, making them far more expensive than the patch or pill. The new healthcare reform law requires health insurance plans to cover birth control without co-payments and some publicly funded health clinics offer birth control for free or at a reduced cost.

Other groups, such as the American Academy of Pediatrics, have been more cautious. They do not endorse specific methods of birth control currently, but they are updating their guidelines as well. Some pediatricians have been reluctant to recommend IUDs for teens because of troubles with older models that caused infections and infertility.

The Dalkon Shield was an IUD sold in the 1970s that was linked to dangerous and sometimes deadly infections. Newer IUD’s have been found to be safe, with the risk of pelvic infection only increasing slightly the first three weeks after insertion.

The new hormonal implant is an update as well. The old style used six rods, which sometimes didn´t stay in place. This style is no longer sold in the U.S. The new version uses just one thin rod. IUDs and implants can be removed at any time with no lasting effect on fertility.

“The ones on the market today are extremely safe,” said Dr. Mary Fournier, an adolescent medicine specialist at Chicago’s Ann & Robert H. Lurie Children’s Hospital, who praised the new recommendations. “That is what everybody should be telling their patients.”

Dr. Fournier already recommends IUDs for her patients and is receiving training in the insertion of the implant devices.

Dr. Raine-Bennett, who is the research director for women’s health at Kaiser Permanente, said she gets mixed reactions from her patients about both methods.

“Some of them say, ‘Great! Something that I don’t have to think about.’ Others are, like, ‘Hmmm, something in my body?’ It really varies,” she said.

The most important thing is for doctors to be sensitive and provide detailed information for their clients, dispelling any myths and allowing teens to make informed decisions. Dr. Debra Braun-Courville, from Mount Sinai Medical Center, says, “Even if adolescent health care providers cannot physically provide the IUD as a method of contraception for their patients because of training and insertion limitations, hopefully this report will encourage them to seek alternative clinical facilities and providers who can provide this option.”

23 Nuclear Power Plants Are In Tsunami Risk Areas

April Flowers for redOrbit.com — Your Universe Online

In March 2011, Japan was hit with a tsunami as a result of a magnitude 9.0 undersea earthquake. The tsunami waves reached heights of 133 feet and traveled about 10 kilometers inland. The earthquake was so enormous that it actually shifted the main island of Japan 8 feet east and shifted the Earth on its axis by 4 — 10 inches.

As if that weren’t bad enough, the tsunami caused the largest nuclear disaster since the Chernobyl incident by compromising the Fukushima I Nuclear Power Plant with a series of equipment failures, nuclear meltdowns and releases of radioactive materials.

A study, published in Natural Hazards, has identified 23 nuclear power plants that are at risk of suffering similar damage in the event of another tsunami. These 23 plants, housing 74 reactors (including those of Fukushima I) are located in the east and southeast of Asia.

Until the Fukushima incident, which was a level 7 on the International Nuclear Event Scale, scientists hadn’t realized the potential for pollution and environmental damage that tsunamis represented. Because the tsunamis themselves are difficult to predict, the research team assessed “potentially dangerous” areas that are home to completed nuclear plants or those under construction.

The team used archaeological, geological and instrumental records to create a map of the geographic zones of the world that are most at risk of damage by large tsunamis, enabling them to find the 23 that are at the most risk. Of these, 13 plants, comprised of 29 reactors, are currently active; four others that have 20 reactors are being expanded to house nine additional reactors; and seven more plants, with a sum total of 16 reactors, are under construction.

“We are dealing with the first vision of the global distribution of civil nuclear power plants situated on the coast and exposed to tsunamis,” explained José Manuel Rodríguez-Llanes, researcher at the Centre for Research on the Epidemiology of Disasters (CRED) of the Catholic University of Leuven in Belgium.

Although the same natural disasters threaten nearly the entire western coast of the Americas, the Spanish / Portuguese Atlantic coast, and the coast of North Africa, the potential for damage is greater on the eastern Mediterranean and parts of Oceania, especially in South and Southeast Asia, due to the presence of nuclear power plants.

Debarati Guha-Sapir, CRED researcher, states, “the impact of natural disaster is getting worse due to the growing interaction with technological installations.”

China is home to 27 out of 64 nuclear reactors currently under construction in the world, indicating the massive investment China has made to nuclear power.

“The most important fact is that 19 (two of which are in Taiwan) out of the 27 reactors are being built in areas identified as dangerous,” state the authors of the study.

In Japan, there are seven plants at risk, with one currently under construction. South Korea is currently expanding two plants to a total of five reactors at risk. India has two reactors, and Pakistan one, that would also suffer in the event of a tsunami.

“The location of nuclear installations does not only have implications for their host countries but also for the areas which could be affected by radioactive leaks,” outlined Joaquín Rodríguez-Vidal, researcher at the Geodynamics and Paleontology Department of the University of Huelva.

The researchers say that we should learn hard lessons from the Fukushima accident. Prevention and previous scientific studies are the best tools for avoiding a repeat of that disaster.

“But since the tsunami in 2004 the Indian Ocean region is still to take effective political measures,” warn the researchers.

Japan has one of the highest standards in scientific knowledge and technological infrastructure, and yet the Fukushima accident still occurred.

“If it had occurred in a country less equipped for dealing with the consequences of catastrophe, the impact would have been a lot more serious for the world at large,” claim the experts.

The team recommends more local analysis to consider the seismic amplification of each nuclear power plant complex and determine the adaptation of installations identified in the study.

NASA Software Award Won By QuakeSim And NASA Mobile App

NASA software that models the behavior of earthquake faults to improve earthquake forecasting and our understanding of earthquake processes, and NASA’s first mobile application are co-winners of NASA’s 2012 Software of the Year Award. The award recognizes innovative software technologies that significantly improve the agency’s exploration of space and maximize scientific discovery on Earth.

QuakeSim, developed at NASA’s Jet Propulsion Laboratory in Pasadena, Calif., is a comprehensive, state-of-the-art software tool for simulating and understanding earthquake fault processes and improving earthquake forecasting. Initiated in 2002, QuakeSim uses NASA remote sensing and other earthquake-related data to simulate and model the behavior of faults in 3-D both individually and as part of complex, interacting systems. This provides long-term histories of fault behavior that can be used for statistical evaluation. QuakeSim also is used to identify regions of increased earthquake probabilities called hotspots.

Studies have shown QuakeSim to be the most accurate tool of its kind for intermediate earthquake forecasting and detecting the subtle, transient deformation in Earth’s crust that precedes and follows earthquakes. Its varied applications include scientific studies, developing earthquake hazard maps that can be used for targeted retrofitting of earthquake-vulnerable structures, providing input for damage and loss estimates after earthquakes, guiding disaster response efforts, and studying fluid changes in reservoirs, among others.

QuakeSim provides model and analysis tools, computational infrastructure, access to data and an interface for understanding the complete cycle of earthquakes. The software assimilates data of crustal deformation that leads to and follows earthquakes, together with seismicity data of earthquakes and geologic data. QuakeSim’s integrated, map-based interfaces and applications make an unprecedented amount of complex geophysical data from the ground, air and space available and accessible to a broad range of scientists and end users, including emergency responders, commercial disaster companies, the insurance industry and civil engineers. The software allows them to explore and analyze observations, model earthquake processes and analyze patterns to focus attention and identify significant and/or subtle features in the data.

QuakeSim has had a number of notable accomplishments to date. It produced the first readily accessible set of digital fault models of California. It was used to identify regions in extreme southern California at risk for earthquakes, guiding the collection of data by NASA’s Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) prior to a magnitude 7.2 earthquake in Baja, Mexico in 2010, which led to the first-ever airborne radar images of deformation in Earth’s surface caused by a major earthquake. It helped define NASA’s planned synthetic aperture radar satellite mission. It was used to rule out tectonic deformation of Earth’s surface as a factor when a spate of water pipe breaks afflicted Los Angeles in 2009. The software also was used in several recent government earthquake response exercises, including the 2008 California ShakeOut, 2011 National Level Exercise and the 2012 Golden Guardian Exercise. QuakeSim approaches are being adopted by numerous organizations, including the Southern California Earthquake Center, United States Geological Survey and the California Geological Survey.

The multidisciplinary QuakeSim team includes principal investigator Andrea Donnellan, Jay Parker, Robert Granat, Charles Norton and Greg Lyzenga of JPL; Geoffrey Fox and Marlon Pierce of Indiana University, Bloomington; John Rundle of the University of California, Davis; Dennis McLeod of the University of Southern California, Los Angeles; and Lisa Grant Ludwig of the University of California, Irvine.

Software engineers at NASA’s Ames Research Center in Moffett Field, Calif., developed the NASA App for mobile platforms including the iPhone, iPod touch, iPad and Android phones and tablets. The NASA App currently has more than 9.6 million user installations and receives more than three million hits per day on average.

The NASA App gathers the agency’s online content, breaking news, image and video collections, news and image feeds, social media accounts, and more in one easy-to-use location that aids public access to science, technology and engineering discoveries. The app’s creators are program manager Jerry Colen, software engineer John Freitas and new media specialist Charles Du.

A NASA software advisory panel reviews Software of the Year entries and recommends winners to NASA’s Inventions and Contributions Board for confirmation. Both Ames and JPL have won individually or shared the award several times since it was initiated in 1994.

For more information about QuakeSim, visit: http://www.quakesim.org

For more information about NASA’s Inventions and Contributions Board, visit: http://icb.nasa.gov

For more information about NASA and agency programs, visit: http://www.nasa.gov

The California Institute of Technology in Pasadena manages JPL for NASA.

Bilateral Cochlear Implants Possibly Aid Binaural Sound Processing

Connie K. Ho for redOrbit.com — Your Universe Online

Researchers from the Stanley Steyer School of Health Professions at Tel Aviv University (TAU) and The Hearing, Speech, and the Language Center at Sheba Medical Center recently noted that bilateral cochlear implants could possibly improve binaural sound processing in the brain.

Cochlear implants, sometimes known as bionic ears, have been used since the end of the 1980 as electronic devices in both ear lobes. They were created to help in boosting the hearing of people who were deaf or hard-of-hearing. The study by TAU showcased how the brain could process the sounds from each ear at the brainstem through “binaural processing.” Binaural processing allows for sound localization, the ability to understand speech in a noisy environment, and an easier way of listening.

“When we hear with both ears, we have an efficient auditory system,” explained Dr. Yael Henkin of TAU in a prepared statement.

According to the Gibson Herald, cochlear implants function as an external speech processor. It can send a digital signal to the internal implant by changing the original sound. The hearing nerve is then stimulated by electrodes, sending out signals to the brain and sound to the wearer of the implant. With cochlear implants, less sound information is received and processed by the brain than would be done with a hearing aid.

The researchers at TAU studied children who had not been born deaf, but who had lost their hearing early on at a young age. The patients who could complete binaural processing were the few who had bilateral cochlear implants. Those who had first received cochlear implants at a young age and then a second pair long after did not have the same skills of binaural processing.

In the study, the team of investigators explained how the two ears work together in creating a complete, unified reception of sound for individuals. The two ears could integrate information and help locate the source of different sounds, so that people could tell the difference from one sound to another.

Participants had to listen to syllables “ta” and “ka” and were required to press a button upon hearing the syllable “ta.” These sounds were sent to the left ear, the right ear, as well as both ears at the same time. At the same time, the scientists studied the brainwave P300, which is linked with auditory discrimination. They discovered a binaural interaction component by comparing the P300 brainwaves during the time at which both ears were stimulated separately and also the time at which the ears were stimulated together.

Based on the findings, a binaural component was found with individuals who had not been born deaf but who had been given bilateral implants early on. Participants who had only one implant for a number of years did not have binaural processing. They believe that, if there is a long duration of auditory deprivation, the implants cannot completely restore hearing.

“Auditory experience prior to cochlear implantation is critical for binaural processing,” noted Henkin in the statement.

The researchers hope that, in the future, the implants will be designed in such a way that they can synchronize with one another and provide patients the necessary elements to have binaural processing.

The study was recent published in the journal Cochlear Implants International.

Battles Between Steroid Receptors To Regulate Fat Accumulation

The androgen receptor in human cells inhibits fat accumulation, but its activity can be sabotaged by glucocorticoids, steroids that regulate fat deposition and are known drivers of obesity and insulin resistance, said researchers led by those at Baylor College of Medicine (www.bcm.edu) in a report in the journal Chemistry & Biology (https://www.cell.com/chemistry-biology/home).

“The project started with a straightforward search for genes or signals specific to human fat cells,” said Dr. Michael A. Mancini (http://www.bcm.edu/mcb/index.cfm?pmid=9330), professor of molecular and cellular biology at BCM, and director of its Integrated Microscopy Core (http://www.bcm.edu/microscopy/). He is senior author of the report and Dr. Sean Hartig, instructor in molecular and cellular biology at BCM, is first author.

“We used a novel approach that combined the gene expression studies with automated microscopy and ‘high content’ image analysis to identify unique signatures specific to human cells and not the mouse cell line usually used in such studies,” said Hartig. The work identified the androgen receptor as a uniquely expressed gene in human fat cells that is both expressed and functional during the early stages of fat cell differentiation.

“Activation of the androgen receptor can inhibit the early stages of human fat maturation,” he said. However, he said, another important steroid receptor — the glucocorticoid receptor — tightly regulates how the androgen receptor is expressed.

High levels of glucocorticoids can lead to lipid accumulation in fat cells and their deposition throughout the body and, in particular, in the abdominal or visceral area. Abdominal fat is associated with higher risks of heart disease and diabetes.

“Using a custom developed image analysis software platform usually found only in large pharmaceutical screening centers, we applied specific algorithms to sensitively detect the glucocorticoid inhibition of androgen receptor activity,” said Mancini. “Without the automated, ‘high content’ image analysis approach, we could not have made these observations.”

High content analysis is one of the latest technologies that allow researchers to collect and analyze images quickly, using special computer algorithms that detect signals within the specimens with exquisite sensitivity. Mancini and members of his teams have pioneered these efforts, especially for application to cell models of nuclear receptor function.

The glucocorticoids can affect the expression of the androgen receptor and inhibit its activity, facilitating fat storage.

“This has implications in this era of an obesity epidemic,” said Mancini. “If you can reduce glucocorticoids, you might be able to upregulate (or increase) androgen receptor activity and regulate fat storage. This work is another example of the how high throughput approaches can enable research to study basic science problems, with a follow-on paths leading to translational science.”

On the Net:

Number Of Factors Raising Suicide Risk In Middle-Aged Men

John Neumann for redOrbit.com – Your Universe Online

Researchers in the UK are suggesting that suicide rates among middle-aged males are climbing after years of dropping off.

Reasons for this trend are varied for individuals, but as a group, a panel of psychologists, economists and social scientists concluded that the pressure to meet the expectations of others is too much for some.

Other reasons include a breakdown in supportive family units and the collapse of traditional male-dominated industries creating a “masculine identity” crisis. Traditionally, males are also more unwilling to discuss personal problems, which could alleviate their self-imposed pressure.

Working class men who have lost not just a job, but an entire career, find themselves struggling to provide for the family. A reluctance to talk about emotions and a greater tendency to turn to drink and drugs were also cited as reasons for the suicide rates among this group, BBC Health News reports.

Rory O´Connor, professor from the University of Stirling, suggested the shift could be partially explained by an aging generation of at-risk people. “The data would suggest it is the same group of people. We think of young people 20 years ago and the societal expectations of what is a successful man or a successful contributor to society, the expectations were particularly high.”

“And with the change in the male role being less well-defined now than it was 20 years ago, men have great difficulty responding to the challenge of how we define ourselves as men.”

The report, commissioned by the UK charity Samaritans, presenting the report at a briefing in London, argues that the pressure to live up to a “gold standard” of masculinity, involving providing for the family, often turns personal troubles such as losing a job into a crisis in a way that it might not for women.

Such issues are more acute in middle age, when the responsibilities are greatest, it adds. Meanwhile major changes in the economy in recent decades, with a shift away from manufacturing, has removed a source of male “pride, identity and companionship”.

The report further found that rapid social change has left middle aged men as a “buffer generation”, caught between the “stiff-upper lip” approach of the previous generation and the very different lives of younger people.

“While suicide is a mental health issue…. it is also a social and health inequality issue. This is unjust and unreasonable,” said Stephen Platt, a University of Edinburgh health policy research professor and trustee for the Samaritans.

“The differences we are highlighting in this report.. are not ones that any civilized society should be comfortable with.”

While the report focused on Britain, the experts said the findings were relevant to many developed countries across the world, especially those that have experienced a post-industrial shift to service-driven economies, reports Kate Kelland for Reuters.

The World Health Organization (WHO) estimates that every year, almost a million people commit suicide – a rate of 16 per 100,000, or one every 40 seconds. It also estimates that for every suicide, there are up to 20 attempted ones.

The Samaritans study found that in Britain, on average, about 3,000 middle-aged men from disadvantaged backgrounds kill themselves each year.

Two Major Breakthroughs In Fields Of Quantum Computing And Mechanics

April Flowers for redOrbit.com – Your Universe Online

Two new studies, both published in Nature this week, outline incredible breakthroughs in the field of quantum mechanics.

Australian engineers led an international team of researchers to create the first working quantum bit based on a single atom in silicon, potentially making another important step toward ultra-powerful quantum computing that theoreticians have dreamt of for decades.

The team describes how they were able to read and write information using the magnetic orientation, or “spin,” of an electron that was bound to a single atom of phosphorus and embedded in a chip made of silicon.

“For the first time, we have demonstrated the ability to represent and manipulate data on the spin to form a quantum bit, or ‘qubit’, the basic unit of data for a quantum computer,” says Scientia Professor Andrew Dzurak.

“This really is the key advance towards realizing a silicon quantum computer based on single atoms.”

The team was led by Dr Andrea Morello and Professor Dzurak from the UNSW School of Electrical Engineering and Telecommunications. The international team also included researchers from the University of Melbourne and University College, London.

“This is a remarkable scientific achievement — governing nature at its most fundamental level — and has profound implications for quantum computing,” explained Dzurak.

According to Dr. Morello, quantum computers may provide a critical tool for solving enormously complicated problems that are now impossible on even the world’s largest supercomputers. Morello explained that such ultra-complex problems include data-intensive issues, such as cracking modern encryption codes, mining vast databases and modeling biological molecules and pharmaceuticals.

This new finding follows a previous study by the same group of researchers in which they demonstrated the ability to read the state of an electron’s spin. The discovery of how to write the spin state now completes the two-stage process that is required to operate a quantum bit.

The new result was achieved by using a microwave field to gain unprecedented control over an electron bound to a single phosphorous atom. The atom was implanted next to a specially-designed silicon transistor. Professor David Jamieson of the University of Melbourne’s School of Physics, led the team that implanted the phosphorous atom into the silicon device.

Jarryd Pla, the lead author of the paper and a PhD student as UNSW, explained, “We have been able to isolate, measure and control an electron belonging to a single atom, all using a device that was made in a very similar way to everyday silicon computer chips.”

According to Dr Morello, “This is the quantum equivalent of typing a number on your keyboard. This has never been done before in silicon, a material that offers the advantage of being well understood scientifically and more easily adopted by industry. Our technology is fundamentally the same as is already being used in countless everyday electronic devices, and that’s a trillion-dollar industry.”

The team’s next goal is to combine pairs of quantum bits to create a two-qubit logic gate, which constitutes the basic processing unit of a quantum computer.

Here in the United States, an international team of scientists led by the University of Florida, is rewriting a page from the quantum physics rulebook using a laboratory once called the coldest spot in the universe.

Most of what science knows about quantum mechanics is theoretical and tested by computer modeling because quantum systems, like electrons zipping around the nucleus of an atom, are difficult to pin down for observation. However, particles can be slowed down and caught in the quantum act by subjecting them to extremely cold temperatures. The new study describes how this freeze-frame approach was recently used to overturn an accepted rule of thumb in quantum theory.

“We are in the age of quantum mechanics,” said Neil Sullivan, a University of Florida physics professor and director of the National High Magnetic Field Laboratory High B/T Facility — home of the Microkelvin Laboratory where experiments can be conducted in temperatures approaching absolute zero.

“If you’ve had an MRI, you have made use of a quantum technology.”

The magnet that powers an MRI scanner is a superconducting coil transformed into a quantum state by very cold liquid helium. Inside the coil, electric current is able to flow free of friction.

Sullivan says that quantum magnets and other strange, almost otherworldly occurrences in quantum mechanics could inspire the next big breakthrough in computer, alternative energy and transportation technologies, such as magnetic levitating trains. However, the practical steps needed bring these technologies into reality cannot be taken without the sign posts and maps that engineers need to navigate the quantum road.

Enter the Microkelvin lab. This is one of the few facilities in the world that is equipped to deliver the extremely cold temperatures needed to slow the “higgledy-piggledy” world of quantum systems at normal temperatures to a manageable pace where it can be observed and manipulated.

“Room temperature is approximately 300 kelvin,” Sullivan said. “Liquid hydrogen pumped into a rocket at the Kennedy Space Center is at 20 kelvin.”

Physicists need to cool things down to 1 millikelvin, one thousandth of a kelvin above absolute zero — that´s  -459.67 degrees Fahrenheit — to bring matter into a state where its quantum properties can be explored.

The Bose-Einstein Condensate, an unstable, transitory phase of matter, is one fundamental state of quantum mechanics that scientists are keen to understand more fully. In this state, individual particles that make up a material begin to act as a single coherent unit. The Bose-Einstein Condensate is a tricky condition to induce in a laboratory setting, but one that researchers need to explore if technology is ever to fully exploit the properties of the quantum world.

Tommaso Roscilde at the University of Lyon, France, and Rong Yu from Rice University in Houston, developed the underlying ideas for the study and asked a colleague, Armando Paduan-Filho from the University of Sao Paulo in Brazil, to engineer the crystalline sample used in the experiment.

“Our measurements definitively tested an important prediction about a particular behavior in a Bose-Einstein Condensate,” said Vivien Zapf, a staff scientist at the National High Magnetic Field Laboratory at Los Alamos and a driving force behind the international collaboration.

The team monitored the atomic spin of subatomic particles called bosons in the crystal to see when the transition to Bose-Einstein Condensate was achieved, and then further cooled the sample to document the exact point where the condensate properties decayed. They observed the anticipated phenomenon when they took the sample down to 1 millikelvin.

The experiment used a crystal that had been “doped” with impurities to create a more realistic scenario.

Zapf said. “It’s nice to know what happens in pure samples, but the real world, is messy and we need to know what the quantum rules are in those situations.”

Thanks to prior simulations, the team knew that the experiment would require them to generate temperatures as low as 1 millikelvin.

“You have to go to the Microkelvin Laboratory at UF for that,” explained Zapf. The lab is located in the National High Magnetic Field Laboratory High B/T Facility and is funded by the National Science Foundation (NSF). Other laboratories can get to the extreme temperature required, but none of them can sustain it long enough to collect all of the data needed for the experiment.

“It took six months to get the readings,” said Liang Yin, an assistant scientist in the University of Florida physics department who operated the equipment in the Microkelvin lab.

“Because the magnetic field we used to control the wave intensity in the sample also heats it up. You have to adjust it very slowly.”

Their findings literally rewrote the rule for predicting the conditions under which the transition would occur between the two quantum states.

“All the world should be watching what happens as we uncover properties of systems at these extremely low temperatures,” Sullivan said. “A superconducting wire is superconducting because of this Bose-Einstein Condensation concept. If we are ever to capitalize on it for quantum computing or magnetic levitation for trains, we have to thoroughly understand it.”

Colorado Man Earns Millions By Eating Popcorn

Michael Harper for redOrbit.com — Your Universe Online

Wayne Watson, a Centennial, Colorado man, has just earned himself a tidy $7.2 million paycheck the old fashioned way: Eating 2 bags of microwave popcorn every day, making sure to deeply inhale the aroma from the bag immediately after it was cooked.

Diagnosed with something called “popcorn lung,” Watson took the makers of the popcorn, as well as the local grocers who sold it to him, to court, claiming the chemicals used in the artificial butter made it difficult for him to breathe.

Watson was first diagnosed with “popcorn lung,” better known as bronchiolitis obliterans at Denver´s National Jewish Health in 2007 after years of breathing in the steam from popcorn bags, according to his lawyer Kenneth McClain.

The culprit in this case is a chemical named diacetyl, which was once used in the artificial butter for the popcorn. Diacetyl has been at the center of other suits from workers in these popcorn manufacturing plants, and since it has been linked to health problems, has since been removed. Mr. Watson, however, claims Gilster Mary-Lee, the manufacturer of the popcorn, didn´t take steps to warn consumers about the dangers of deeply inhaling multiple popcorn bags a day, a misstep he says makes the company liable for 80% of the $7,217,961 in damages. Watson also brought his suit to the retail grocers who sold him the popcorn, making them liable for 20% of the total damages.

“It´s kind of a weird story isn´t it? A guy gets sick by breathing in the toxic fumes of diacetyl that is on butter-flavored microwave popcorn in the sanctity of his own kitchen,” said Watson in an interview with local CBS Denver.

“Who would ever reasonably think that popping popcorn in your own home, no matter how it´s packaged or processed, would all of a sudden turn into an agent for toxic lung disease?”

Lawyers for the defendants in the case, however, claimed Watson didn´t catch his case of bronchiolitis obliterans from microwave popcorn, but from his years of breathing in dangerous chemicals as a carpet cleaner. The jury, however, found in favor of Watson, earning him a massive payout in damages. McClain argued that Mary-Lee should have taken extra steps to ensure the customer´s safety whenever employees began to get sick from the chemical.

“That link gave them knowledge of consumers because in their own plant workers popping popcorn in the quality assurance area were getting sick,” said McClain, also speaking in an interview with CBS Denver.

Watson agreed, saying: “They did absolutely no testing whatsoever that the consumer might be at risk. The only experiment they did was go sell the product and see what happens. They rolled the dice and lost.”

Gilster Mary-Lee has already said they plan to appeal the verdict in this case, saying in a statement: “Gilster-Mary Lee Corp. has manufactured and provided safe, quality microwave popcorn to consumers for over two decades. We are certainly very disappointed by the decision of the jury in this case in light of the very clear evidence which was presented, including the millions of consumers who have safely used and enjoyed microwave popcorn since it was introduced. We are currently evaluating our next steps in this matter and will assert all rights available to us under the law.”

As for Watson, he says this case has left a bad taste in his mouth for popcorn, and hasn´t touched the stuff since 2007.

“Occasionally we´ll pop some on the stove the old fashioned way.”

Overgrowth Of Algae Endangers Coral Ecosystems

April Flowers for redOrbit.com – Your Universe Online

Overfishing and nitrate pollution can destroy coral reefs by allowing an overgrowth of algae that brings with it unwanted pathogens, chokes off oxygen and disrupts helpful bacteria. These are the findings of a new study out of the Oregon State University, published recently in PLoS One.

Large algal species, or “macroalgae,” are big enough to essentially smother corals. These macralgae grow at accelerated rates when sewage waste enters the water and increases nitrate levels, which acts as a sort of algae fertilizer. This accelerated algae growth becomes an even bigger problem when the large fish populations that are the most effective at removing the algal buildup are reduced through over-fishing.

The growth rate of corals has been observed to sink by as much as 37 percent in the presence of macroalgal competition, and other researchers have documented cases of hypoxia, or lack of oxygen.

Specialists in the field refer to this phenomenon as “the slippery slope to slime.”

“There is evidence that coral reefs around the world are becoming more and more dominated by algae,” said Rebecca Vega-Thurber, an OSU assistant professor of microbiology. “Some reefs are literally covered up in green slime, and we wanted to determine more precisely how this can affect coral health.”

The new study found that higher levels of algae cause both a decrease in coral growth rate as well as an altered bacterial community. The algae can also introduce harmful pathogens to the coral and at the same time reduce the levels of helpful bacteria. The useful bacteria help to feed the corals in a symbiotic relationship and also produce natural antibiotics that can help protect the corals from other pathogens.

One algae in particular, Sargassum, was found to be a vector, assisting potentially harmful microbes to enter the coral ecosystem.

Thousands of species of algae exist, and coral reefs have evolved with them in a relationship that often benefits the entire tropical marine ecosystem. When the system is in balance, some algae grow on the reefs, which provides a food source for a variety of fish species. The growth rate of this algae is typically regulated by the availability of certain nutrients, in particular nitrogen and phosphorus, and tropical fish species like the parrot fish consume large amounts of the algae, thus keeping its growth in check.

However, when algal growth is over-stimulated by nutrients in sewage waste water from coastal areas, and overfishing simultaneously curbs algal consumption at the same time, then this delicate balance can be disrupted.

“This shows that some human actions, such as terrestrial pollution or overfishing, can affect everything in marine ecosystems right down to the microbes found on corals,” Vega-Thurber said. “We´ve suspected before that increased algal growth can bring new diseases to corals, and now for the first time have demonstrated in experiments these shifts in microbial communities.”

At some high-value coral reefs, the problem is being directly addressed through the mechanical removal of algae. This process is costly, however, and researchers say that the best long-term solution to algal overgrowth is to reduce pollution and overfishing so that the ecosystem´s natural balance can be restored.

Investigative Compound Reduces Fragile X Symptoms In First Human Trials

Connie K. Ho for redOrbit.com — Your Universe Online

Poor eye contact. Loss of language skills. These are just a few behavior attributes of individuals with autism spectrum disorder (ASD), according to the National Institute of Health. Scientists at the Rush University Medical Center and the University of California, Davis MIND Institute recently discovered that an investigational compound focusing on the main symptoms of fragile X syndrome is able to help treat social withdrawal. The finding is unique in that the compound could possibly be used to treat patients with ASD.

The results of the study were recently published online for the journal Science Translational Medicine.

“There are no FDA-approved treatments for fragile X syndrome, and the available options help secondary symptoms but do not effectively address the core impairments in fragile X syndrome,” explained lead author Dr. Elizabeth Berry-Kravis, a professor of Pediatrics, Neurological Sciences, and Biochemistry at Rush University, in a prepared statement. “This is the first large-scale study that is based on the molecular understanding of fragile X syndrome and, importantly, suggests that the core symptoms may be amenable to pharmacologic treatment.”

The compound STX 209, also known as Arbaclofen, was included in the “first-in-patient” drug trial.

“This study shows that STX 209 is an important part of the treatment for fragile X syndrome, because it improved symptoms in those with significant social deficits or autism as well as fragile X syndrome,” commented Dr. Randi Hagerman, medical director of the MIND Institute at UC Davis, in the statement. “Additional studies also are suggesting that STX 209 can be helpful for autism without fragile X syndrome. Until now, there have been no targeted treatments available for autism. This appears to be the first.”

One of the most well-known single-gene causes of autism, fragile X syndrome causes intellectual impairment and social impairment. According to the U.S. Centers for Disease Control and Prevention (CDC), there are about 1 in 4,000 males and 1 in 6,000 to 8,000 females who display symptoms of social impairment. The organization also predicts that there are approximately 1 in 88 children born today who will be diagnosed with autism.

“This study will help to signal the beginning of a new era of targeted treatments for genetic disorders that have historically been regarded as beyond the reach of pharmacotherapy,” noted Berry-Kravis in the statement. “It will be a model for treatment of autism, intellectual disability and developmental brain disorders based on understanding of dysfunction in brain pathways, as opposed to empiric treatment of symptoms. We hope mechanistically-based treatments like STX209 ultimately will be shown to improve cognitive functioning in longer-term trials.”

By studying mice that were genetically engineered to display symptoms of fragile X, the scientists came to understand that behavioral issues in fragile X are due to the lack of neurotransmitter gamma-amino butyric acid (GABA). A drop in GABA has been seen in mice with fragile X and is believed to cause social anxiety or avoidance of others. In particular, Arbaclofen is effective in combining with a receptor on a synapse to cause a psychological reaction that would normally happen with a naturally occurring substance. The mice who were treated with arbaclofen displayed less social avoidance and repetitive behavior.

“In preclinical results, we demonstrate that STX209 treatment corrects core aspects of FXS pathophysiology in the fragile X mouse model, leading us to conclude that STX209 is a disease-modifying drug with the potential to significantly improve the lives of patients with fragile X,” commented Dr. Randall Carpenter, president and chief executive officer of participating organization Seaside Therapeutics, in the statement. “STX209 could have a positive effect in this larger patient population.”

The study with humans was the first of its kind and included 63 participants who ranged from six to 39 years of age. Between December 2008 and March 2010, 56 of the study subjects were included in the clinical trial and returned for an evaluation at two- and four-week intervals following treatment that spanned six weeks. The results of the medication were evaluated with the Aberrant Behavior Checklist, which looked at factors like irritability, lethargy/withdrawal, repetitive behavior and hyperactivity.

The findings showed that there was improvement for the participants and a lessening of problematic behaviors.

“There are currently no FDA approved therapeutics that address the core symptoms of fragile X syndrome, leaving patients and their caregivers with limited treatment options,” replied Berry-Kravis in a statement. “We are very excited about the clinically meaningful improvements in social impairment observed to date in patients receiving STX209 – marking the first time a drug candidate has positively impacted a specific core symptom of fragile X. With continued success in ongoing clinical trials, I am hopeful that STX209 may be able to transform the treatment paradigm for fragile X syndrome – which would confirm what I have believed all along – that intellectual disability is not, as previously understood, an immutable condition.”

The researchers plan to continue their study on STX 209, fragile X syndrome, and autism.

“We are looking forward to further studies utilizing STX 209 in both autism and fragile X syndrome because the fragile X mouse studies demonstrate long-term strengthening of synaptic connections with continued use of this medication,” concluded Hagerman in the statement.

Escherichia Coli Helps Researchers Understand How Organisms Evolve New Functions

April Flowers for redOrbit.com – Your Universe Online

Michigan State University researchers and colleagues from the University of Texas and the University of Calgary have documented the step-by-step process in which organisms evolve new functions.

The study results are revealed through an in-depth, genomics-based analysis that decodes how E. coli bacteria figured out how to supplement a traditional diet of glucose with an extra course of citrate.

“It´s pretty nifty to see a new biological function evolve,” said Zachary Blount, postdoctoral researcher in MSU´s BEACON Center for the Study of Evolution in Action. “The first citrate-eaters were just barely able to grow on the citrate, but they got much better over time. We wanted to understand the changes that allowed the bacteria to evolve this new ability. We were lucky to have a system that allowed us to do so.”

If oxygen is present, normal E. coli can’t digest citrate. It’s a distinctive hallmark of E. coli that they can’t eat citrate because the E. coli doesn’t express the right protein to absorb citrate molecules.

To decipher the responsible mutations, Blount worked with Richard Lenski on Lenski’s long-term experiment, cultivating cultures of fast-growing E. coli. Launched in 1988, the project has allowed Lenski and his colleagues to study more than 56,000 generations of bacterial evolution.

The experiment demonstrates natural selection at work. And because samples are frozen and available for later study, when something new emerges scientists can go back to earlier generations to look for the steps that happened along the way.

“We first saw the citrate-using bacteria around 33,000 generations,” Lenski explained. “But Zack was able to show that some of the important mutations had already occurred before then by replaying evolution from different intermediate stages. He showed you could re-evolve the citrate-eaters, but only after some of the other pieces of the puzzle were in place.”

The research, published in Nature, analyzed 29 genomes from different generations to find the mutational pieces of the puzzle to uncover a three-step process in which the bacteria developed this new ability.

Potentiation is the first step, when the E. coli accumulated at least two mutations that set the stage for later events. Then came actualization, when the bacteria first began eating citrate but only just nibbling at it. The final stage, refinement, involved mutations that greatly improved the initially weak function. This allowed the citrate eaters to devour their new food source, becoming dominant in the population.

“We were particularly excited about the actualization stage,” Blount said. “The actual mutation involved is quite complex. It re-arranged part of the bacteria´s DNA, making a new regulatory module that had not existed before. This new module causes the production of a protein that allows the bacteria to bring citrate into the cell when oxygen is present. That is a new trick for E. coli.”

The change was far from normal, Lenski said.

“It wasn´t a typical mutation at all, where just one base-pair, one letter, in the genome is changed,” he said. “Instead, part of the genome was copied so that two chunks of DNA were stitched together in a new way. One chunk encoded a protein to get citrate into the cell, and the other chunk caused that protein to be expressed.”

Did The Eltanin Meteor Cause More Than Tsunamis?

April Flowers for redOrbit.com – Your Universe Online

Around 2.5 million years ago, a huge meteor collided with the Earth and fell into the southern Pacific Ocean. A new study, published in the Journal of Quaternary Science, suggests that not only could this have caused a massive tsunami, but it may also have plunged the world into the Ice Ages.

A research team from Australia says that because the Eltanin meteor — which was up to two kilometers across — crashed into deep water, the potential for immediate catastrophic impacts on coastlines around the Pacific Rim or the meteor’s capacity to destabilize the entire planet’s climate system has largely been ignored by the scientific community.

“This is the only known deep-ocean impact event on the planet and it´s largely been forgotten because there´s no obvious giant crater to investigate, as there would have been if it had hit a landmass,” says Professor James Goff, co-director of UNSW´s Australia-Pacific Tsunami Research Centre and Natural Hazards Research Laboratory.

“But consider that we´re talking about something the size of a small mountain crashing at very high speed into very deep ocean, between Chile and Antarctica. Unlike a land impact, where the energy of the collision is largely absorbed locally, this would have generated an incredible splash with waves literally hundreds of meters high near the impact site.”

“Some modeling suggests that the ensuing mega-tsunami could have been unimaginably large — sweeping across vast areas of the Pacific and engulfing coastlines far inland. But it also would have ejected massive amounts of water vapor, sulfur and dust up into the stratosphere.”

“The tsunami alone would have been devastating enough in the short term, but all that material shot so high into the atmosphere could have been enough to dim the sun and dramatically reduce surface temperatures. Earth was already in a gradual cooling phase, so this might have been enough to rapidly accelerate and accentuate the process and kick start the Ice Ages.”

Goff and colleagues from UNSW and the Australian Nuclear Science and Technology Organization note that geologists and climatologists have interpreted geological deposits in Chile, Antarctica, Australia, and elsewhere as evidence of climatic change. This marked the beginning of the Quaternary period, the most recent period of the Cenozoic Era. This period is characterized by a series of glaciations and the appearance and spread of modern humans.

Alternatively, the study suggests that some or all of these deposits could be the result of mega-tsunami inundation.

“There´s no doubt the world was already cooling through the mid and late Pliocene,” says co-author Professor Mike Archer. “What we´re suggesting is that the Eltanin impact may have rammed this slow-moving change forward in an instant – hurtling the world into the cycle of glaciations that characterized the next 2.5 million years and triggered our own evolution as a species.”

“As a ℠cene´ changer – that is, from the Pliocene to Pleistocene – Eltanin may have been overall as significant as the meteor that took out the non-flying dinosaurs 65 million years ago. We´re urging our colleagues to carefully reconsider conventional interpretations of the sediments we´re flagging and consider whether these could be instead the result of a mega-tsunami triggered by a meteor.”

Heart Disease Risk Increases With Temperature Extremes

Michael Harper for redOrbit.com — Your Universe Online

The crazy weather we´ve been submitted to in recent years is more than a nuisance or even the subject of small talk down at the local coffee shop. According to new research today in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal, the extreme temperatures, which often accompany unpredictable weather, can also increase the risk of premature cardiovascular disease (CVD) death.

To test this hypothesis, researchers traveled to Brisbane, Australia to analyze the association between the years of life lost as a result of CVD and the average daily temperature in the region. To determine the estimate of years of life lost, the team compared the age of death with the average life expectancy.

According to the study´s lead researcher and Ph.D. scholar, Cunrui Huang, M.Med., M.S.P.H., it is important to understand how these extreme temperature changes, a result of climate change, affect humans, especially those who are obese.

As the temperatures rise and fall dramatically, says Huang, so too does our blood pressure, blood thickness, cholesterol and even heart rate.

“With increasing rates of obesity and related conditions, including diabetes, more people will be vulnerable to extreme temperatures and that could increase the future disease burden of extreme temperatures,” said Huang.

Huang and his research team collected temperature data in Brisbane from 1996 to 2004, then compared this data to the number of CVD-related deaths which occurred during the same time frame.

The summers in Brisbane are normally hot and humid, while the winters remain largely dry and mild. Altogether, the average daily temperature in Brisbane between 1996 and 2004 came in at 68.9 degrees Fahrenheit, or 20.5 Celsius. Huang and team then characterized a cold snap and heat wave as the coldest and hottest 1% of all these days.

For every 1 million people, said Huang, 72 years of life were lost as a result of CVD.

Whenever the temperatures began to climb towards their upper peaks for 2 or more days, however, the risk of premature CVD death also rose.

“This might be because people become exhausted due to the sustained strain on their cardiovascular systems without relief, or health systems become overstretched and ambulances take longer to reach emergency cases,” said co-author of the study and professor of biostatistics at Queensland University of Technology, Dr. Adrian G. Barnett.

“We suspect that people take better protective actions during prolonged cold weather, which might be why we did not find as great a risk of CVD during cold spells.”

According to the American Heart Association, cold weather can be just as dangerous for your heart as warm weather.

When body temperature drops below 95 Fahrenheit, hypothermia sets in, meaning the body can´t create enough energy to keep itself warm. When this happens, the heart usually fails first, causing most hypothermia deaths.

In conclusion, Mr. Huang and Dr. Barnett suggest that, when the temperatures begin to spike or plummet, it´s best to remain indoors under temperate conditions. This way, the risk of premature CVD death is kept to a minimum.

The researchers are, however, willing to admit that the results of this study might be specific to the people of Brisbane, and might not have universal implications.

Spine Injuries In Military Personnel Are Caused Mainly By Explosions

Study of spinal injury data may help surgeons treat injured soldiers or civilians

Spinal injuries are among the most disabling conditions affecting wounded members of the U.S. military. Yet until recently, the nature of those injuries had not been adequately explored.

In a new study recently published in the Journal of Bone and Joint Surgery (JBJS), a team of orthopedic surgeons reviewed more than eight years of data on back, spinal column, and spinal cord injuries sustained by American military personnel while serving in Iraq or Afghanistan. The injuries were then categorized according to anatomic location, neurological involvement, the cause of the injury, and accompanying wounds.

The resulting analysis is an important first step in helping orthopedic surgeons develop treatment plans for these service members, as well as for severely injured civilians who sustain similar disabling injuries.

Key Findings:

-Of 10,979 evacuated combat casualties, 598 (5.45 percent) sustained a total of 2,101 spinal injuries.
-Explosions accounted for 56 percent of spine injuries, motor vehicle collisions for 29 percent, and gunshots for 15 percent.
-92 percent of all injuries were fractures.
-The average age at the time of injury was 26.5 years of age.
-90 percent of the injured were enlisted personnel.
-84 percent of patients sustained their wounds as a result of combat.
-In 17 percent of injuries to the spine, the spinal cord also was injured.
-53 percent of all gunshot wounds to the spine resulted in a spinal cord injury.
-Spinal injuries were frequently accompanied by injuries to the abdomen, chest, head, and face.

“In these current military conflicts, the latest technologies in body armor, helmets, and other protective devices have helped save many soldiers’ lives,” says James A. Blair, MD, an orthopedic surgery chief resident in the Department of Orthopaedics and Rehabilitation, Brooke Army Medical Center, Fort Sam Houston, TX. “We also have access to advanced life-saving techniques in the field and medical evacuation strategies that are keeping many more service members alive.

“But when a person survives an explosion or vehicle collision, there has still been a great deal of force on the body,” Blair adds. “Many of those survivors are coming to us with severe injuries to their spine and back. We needed to describe and characterize these injuries so recommendations can be made on how to provide the most effective treatment and rehabilitation for our wounded warriors.”

Although the survival rate is high for such injuries, the disability rate also is quite high. This affects not only the service members, but also their families and the U.S. healthcare system. Therefore, the study’s authors note, further research is required to improve future outcomes for those with spinal injuries.

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Minorities Make Up Nearly Half Of Kidney Recipients In Live Donor Chains

Finding allays fears that minorities would be disadvantaged by expansion of the donor pool

The largest U.S. multicenter study of living kidney transplant donor chains showed that 46 percent of recipients are minorities, a finding that allays previous fears that these groups would be disadvantaged by expansion of the donor pool through this type of exchange process.

The study of a series of chain transplantations performed from February 2008 to June 2011 at 57 centers nationwide included 272 kidney transplants that paired organ donors who were incompatible with their relatives with strangers providing organs for altruistic reasons or with others donating an organ to an unknown patient because they were not a match for their own relatives.

“Of all living donor kidney transplants performed in the United States in 2011, only 33 percent were to ethnic minorities. So the fact that nearly 50 percent of the chain transplants were ethnic minorities is a real game changer,” said senior study author and UCLA transplant surgeon Dr. Jeffrey Veale. “This collaborative team has been able to show that with donor chains we can broaden, increase and diversify the population of patients who can receive kidney transplants.”

“We were incredibly happy with the results,” said study first author Dr. Marc Melcher, a transplant surgeon at Stanford Hospital & Clinics and assistant professor of multi-organ transplantation surgery at Stanford University. “It demonstrates that through the cooperation of altruistic strangers we can generate multiple transplants and reduce the competition for deceased organs.”

The study, which appears in the September issue of the peer-reviewed American Journal of Transplantation, notes that the larger percentage of minority recipients may be a result of large urban centers with more ethnic diversity actively participating in chains.

“About 30 percent of patients needing a kidney transplant discover that their friends and relatives are incompatible as donors. Donor chains create opportunities for potentially endless donor-recipient pairings,” Melcher said.

A chain can start when an altruistic donor generously donates a kidney to a stranger on dialysis. This recipient’s original incompatible willing donor then passes on the generosity to another patient on dialysis to keep the chain going, essentially “paying it forward,” and the process can be repeated to extend the chain further.

This collaborative effort is made possible thanks to kidney registries like the National Kidney Registry, a nonprofit organization that uses a specialized computer program to match donors and recipients across the country. The registry has helped hundreds of patients who have antibodies to their loved ones receive a kidney from a stranger as part of a chain of transplants. The world’s longest kidney transplant chain, facilitated by the registry, involved 60 patients.

Donated kidneys can remain outside the body on ice for prolonged periods of time, allowing the organs to be shipped via commercial airlines to recipients in another state. This expands the donor pool for difficult-to-match patients awaiting transplants, like many included in this study.

About 92,000 people currently are on the kidney transplant waiting list in the United States, according to the United Network for Organ Sharing. California alone has more than 16,000 people on the list. Patients often can wait more than a decade for a suitable organ, and about 19 percent of those on the waiting list are seeking their second, third or fourth kidneys.

Increasing the pool of available kidneys is vital and means more transplants could be performed annually, getting patients off dialysis earlier, Melcher said.

“Dialysis is typically three times a week, four hours a day. The procedure is extremely draining, which is why patients often lose their jobs and cannot lead normal lives,” Melcher said. “The worst part is that over 4,000 patients a year die while on the waiting list for kidney transplants. So many lives could be saved if we can expand the living kidney transplantation donor chain program.”

Increasing the number of kidney transplants per year also reduces health care expenditures, Veale said. It costs about $70,000 a year to maintain a patient on dialysis, while it costs only about $20,000 to care for a patient who has undergone transplantation, most of that expense is for medications and follow-up visits. Additionally, living donor kidneys last about twice as long as organs removed from deceased donors. Therefore, the health system saves approximately $500,000 each time a patient receives a transplant, Veale said. It is one of the few examples in medicine where the standard of care is much less expensive than the next option – dialysis, in this case.

The next step, which Veale reported recently in the New England Journal of Medicine, is to expand the donor pool internationally, possibly into Canada or Europe, similar to what happened with the bone marrow registry.

“A kidney that could free a patient in California from the constraints of dialysis may be found in a donor who lives in London, Barcelona or Vancouver,” said Veale, who also is director of the UCLA Kidney Exchange Program.

One recipient’s story:

For La Canada resident Keenan Cheung, a 47-year-old housing director at the University of Southern California, a kidney transplant chain was life changing. Cheung was born with polycystic kidney, an inherited disease in which many cysts form in the kidneys. He was fine until his 40th birthday, when his kidneys started to fail. He put his name on a waiting list for a donor kidney and began continuous ambulatory peritoneal dialysis, a four-times-a-day process that required a tube in his peritoneum by which waste products were removed from the blood and excess fluid drained from his body.

After several years on dialysis, he suffered a grand mal seizure in January of 2009. His health quickly deteriorated. He already knew that his wife, Jeanne, and his brother and mother were not compatible donors. Joining a kidney chain became the ideal solution for him. Cheung received a kidney from an African American man in Long Beach who couldn’t donate his kidney to his mother because they were incompatible. Cheung’s wife, Jeanne, then donated her kidney to a Hispanic girl from Commerce who needed an organ but didn’t have a match.

Cheung got his transplant in June of 2009 and is doing wonderfully, living a full and happy life and coaching all three of his sons’ sporting teams.

“I was on death’s doorstep. I was miserable,” Cheung said of his life prior to the transplant. “Today I could not be better. I’m healthy, I exercise, I coach my sons’ teams. I can golf, swim, hike – all of the things I couldn’t do on dialysis. Getting this kidney was life changing.”

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Soldiers Suffer From Mental Illness Due To War

One in every two cases of post-traumatic stress disorder (PTSD) in soldiers remains undiagnosed. This is the conclusion reached by a working group led by Hans-Ulrich Wittchen et al. They report their study in the current issue of Deutsches Ärzteblatt International (Dtsch Arztebl Int 2012; 109(35): 559), which is a special issue focusing on the prevalence of psychological stress in German army soldiers. In a second original article, results reported by Jens T Kowalski and colleagues show that more female soldiers contact the psychosocial support services provided by Germany’s armed forces than their male colleagues (Dtsch Arztbl Int 2012; 109 (35): 559).

Wittchen et al. draw attention to the fact that thus far no information has been available on how commonly soldiers have traumatic experiences during deployments to Afghanistan and develop PSTD. In their study, 85% of all soldiers deployed overseas reported at least one distressing event, but usually several such events. Overseas deployment is associated with twice or four times the risk of PTSD for soldiers. In international comparison, the prevalence of PTSD is notably lower in German soldiers, at 2.9%, than in soldiers from other countries who are deployed in the same regions. However, the estimated proportion of undiagnosed and untreated cases of PTSD is 45%.

Kowalski et al. explain that it is not only Afghanistan from where soldiers return in a traumatized state but also Kosovo. The number of Kosovo returnees with mental problems in their study increased significantly compared to the number of traumatized soldiers returning from Afghanistan. The study is based on hospital data of all German army psychiatric wards; these data evaluated the psychiatric morbidities between January 2010 through June 2011. The most common diagnoses were adjustment disorders, PSTD, and mild and moderate depressive episodes.

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Brain Activity Helps Predict Individual’s Test Performance

Lee Rannals for redOrbit.com — Your Universe Online

Scientists are monitoring brain activity to help try and predict how well someone will perform on a test they have been studying for, and how to better improve study habits.

Researchers at Sandia National Laboratories have shown it is possible to predict how well people will remember information. The team demonstrated predictions based on the results of monitoring test volunteers with electroencephalography (EEG) sensors.

Laura Matzen of Sandia´s cognitive systems group said: “If you had someone learning new material and you were recording the EEG, you might be able to tell them, ℠You´re going to forget this, you should study this again,´ or tell them, ℠OK, you got it and go on to the next thing.”

Matzen and her team monitored test subjects’ brain activity while they studied word lists, and they used the EEG to predict who would remember the most information.

The team had a baseline of what brain activity looked like for good and poor memory performance, because they already knew average percentage of correct answers under various conditions.

The computer model predicted five of 23 people tested would perform best, and the team said the model was correct. Those people remembered 72 percent of the words on average, compared to 45 percent for everyone else.

Ultimately, the study is part of Matzen’s long-term goal to understand the Difference Related to Subsequent Memory, or Dem Effect, which is an index of brain activity encoding that distinguishes subsequently remembered from subsequently forgotten items.

Matzen is interested in what causes the effect, and what can change it, with hopes that her research will eventually lead to improvements in how students learn. She said she hopes to discover how training helps people performing at different levels and whether particular training works better for certain types of people.

One of Matzen’s goals is to find out whether recording a person’s brain activity while they use their natural approach to studying can predict what kind of training would work best for that person.

A next step would be to use real-world memory working tasks, like what military personnel would have to learn as new recruits.

The researchers used about 90 volunteers in a second part of the study, who spent nine to 16 hours over five weeks in testing for the memory training techniques study. Their first session developed a baseline for how well they remembered words or images.

The team used a control group with no training for the study, and a second group who practiced mental imagery strategy. A final group went through “working memory” training to increase how much information they could handle at a time.

Each volunteer in the study watched a screen that flashed words or images for one-second, and then were given periodic quizzes on how well the person remembered what was shown.

“It´s designed to be really difficult because we want lots of room to improve after memory training,” Matzen said in a press release.

The team divided the test into five sections, each about 20 minutes long followed by a break to keep volunteers alert.

When performance was compared before and after training, the control group did not change, but the mental imagery group’s performance improved on three of the five tasks.

“Imagery is a really powerful strategy for grouping things and making them more memorable,” Matzen said in the release.

The working memory group did worse on four of the five tasks after training.

Matzen said the imagery training group learned a strategy, while working memory training simply tried to push the limits of memory capacity.

Although the imagery group performed better, they made more mistakes than the other groups when tested on “lures” that were similar as the items they had memorized.

“They study things like ℠strong adhesive´ and ℠secret password,´ and then I might test them on ℠strong password,´ which they didn´t see, but they saw both parts of it,” Matzen said in the release. “The people who have done the imagery training make many more mistakes on the recombinations that keep the same concept. If something kind of fits with their mental image they´ll say yes to it even if it´s not quite what they saw before.”

She presented the results of the first part of the study in April at the Cognitive Neuroscience Society conference in Chicago. She presented the preliminary findings on the second part of the study this summer to the Cognitive Science and Technology External Advisory Board.

Llama, Lama glama

Llama, Lama glama

The llama (Lama glama) is a domesticated camelid from South America. It is often used as a pack animal or for meat by Andean cultures. Its hair is used to make clothing and handicrafts. The course outer hair is typically used to make lead ropes, rugs, and wall hangings, and the fibers can come in many colors ranging from black to reddish brown to white. Because of transportation and trade of this species, there are now more than 158,000 llamas and 100,000 alpacas in Canada and the United States.

The llama was first described as similar to a sheep, but it was quickly acknowledged as closer to the camel. In Systema Naturae, written by Linnaeus in 1758, the llama was described with the camel and alpaca, but Cuvier changed this classification in 1800, which placed it in a separate genus, Lama, from the alpaca. This genus is one of four genera, including Vicugna and the two species of true camels that comprise the suborder Tylopoda, which holds the unique species of even-toed ungulates with odd bumps on the feet.

In the nineteenth century, paleontologists Leidy, Cope, and Marsh interpreted the information gathered on extinct Tertiary wildlife in North America, which expanded the knowledge of the llama and its family. From this information, it was found that llamas were not always confined to South America for a natural range. Fossils of llama-like creatures were found in deposits from the Pleistocene era were found in South America and the Rocky Mountains. These specimens were significantly larger than the llamas of today. These North American llamas were classified under the genus Hemiauchenia, and it is thought that these llamas were common in areas now known as Texas, California, Utah, New Mexico, Missouri, and Florida 25,000 years ago.

The llama can grow to have an average height between 5.5 and 6 feet with a weight of up to 450 pounds. The teeth structure of the llama is similar to a camel’s, but it does differ slightly. Its skull also resembles that of a camel, but bares smaller nasal cavities. The ears are curved inwards and can be compared to bananas. The tail is short, and the toes are separated farther than the toes of the camel. There are four species in the Lama genus, all of which are part of a controversy among naturalists, because all four have similar habits and appearances. These species are the llama, the alpaca, the vicuña, and the guanaco.

The llama and the alpaca are the only species within the Lama genus that are completely domesticated, and as a result, they can be found in many different sizes and colors. The colorings of these two species include white, black, piebald, brown, and grey. The vicuña and the guanaco, and endangered species, can be found in the wild, and these species are typically light brown in color with white underbellies. These species can be found in different ranges and differ in appearance.

The llama is a sociable creature and is easily trained to a halter and lead once weaned. It is typically well behaved and curious, approaching most humans with no problems. However, if a llama is too socialized and bottle-fed when young, its behavior will become difficult once weaned. When this happens, the llama will treat humans with the same behaviors it uses for other llamas, which include kicking, spitting, and neck wrestling.

In herds, llamas typically spit when individuals lower in the hierarchy have stepped out of line. The hierarchy changes often, with males often causing small fights to gain dominance. These fights can be seen as violent, but usually only result in one llama losing its balance. Females spit in an attempt to control other individuals within a herd. Llamas also take care to protect the herd, braying if threatened to alert the herd of the danger. Llamas will communicate with a humming noise, and a “mwa” vocalization is used when an individual is angered or irritated. When irritated, the llama will lay its ears back, and the level of irritability level can be determined by the content of the spit.

Adult male llamas emit an “orgle” vocalization that is similar to a gargle when sexually aroused. This vocalization can be made during the process of mating. Female llamas do not go into estrous, or heat, but are able to produce an egg when mating. This is known as induced ovulation, and is rare among large mammals. Llamas will mate while lying down for up to 45 minutes, another unusual reproductive trait for a large mammal. The pregnancy period of a dam, or female breeding llama, can last up to 350 days, after which one cria, or baby, is born.

Instead of licking the cria, a mother llama will hum to her young, and nuzzle it. Llamas give birth in an all-female group, with other mothers surrounding the birthing mother and the cria in order to protect it from males and possible predators. Birth takes up to thirty minutes, and typically occurs in the warmer daylight hours between 8 AM and noon. The cria is able to walk and nurse within the first hour of its life. It is also fed salt as a dietary supplement.

The llama is able to breed in three different manners, depending upon a herder’s preference. Harem breeding consists of one male being left with a group of females year-round. Field breeding can be considered the easiest way of breeding, and occurs when one female with placed with one male and remains with him until she becomes pregnant. The most efficient method of breeding, known as hand breeding, consists of placing a male and female together in the same pen. Humans monitor the breeding, and both individuals will be separated and bred every other day in this way, until one or both llamas refuse to breed. After two or three weeks, if the female does not show signs of being pregnant, she is bred again using hand breeding.

In the 1980’s, humans began using llamas to guard livestock herds and sheep. This typically occurs in the western areas of the United States, where predators like coyotes are common. Usually only one castrated male, or gelding, is needed to protect a herd. This method of protecting a herd is accomplished when the gelding bonds with the livestock, but if more llamas are used, the chances of bonding between the livestock and the llama declines, so it is suggested that only one llama be used. Bonding between sheep or goats and a guard llama is more easily accomplished when the livestock are young, and the llama will become most protective these individuals. Using guard llamas is not costly, and requires little training, so many producers have found it to be an efficient means of livestock protection.

Llamas have been used in many cultures throughout their range. In pre-Incan cultures like the Moche culture, llama parts were placed in burial sites alongside important people, as provisions or gifts for the afterlife. In the Incan culture, llamas were used as pack animals, and often times Incan nobility were buried with llama figurines. One Incan deity, Urcuchillay, was portrayed as a multi colored llama. One scholar, Alex Chepstow-Lusty has even asserted that the llama was vital to the switch from hunting and gathering to farming, because llama dung was used as fertilizer. During the Spanish conquest, llamas were used to carry ore from mines. One estimate deduced by Gregory de Bolivar suggested that during his time, nearly 300,000 llamas were used to transport ore.  Because other pack animals like horses are now more common, llamas are not often used as heavy pack animals today.

Image Caption: A Llama lying down, also called “kushing”. Credit: Johann “nojhan” Dréo/Wikipedia (CC BY-SA 3.0)

Painkillers May Lead To More Headaches, Trapping People In A “Vicious Cycle”

Lawrence LeBlond for redOrbit.com – Your Universe Online

Painful headaches that affect nearly a million people in the UK, and many more millions worldwide, may be partly caused by overuse of common painkillers such as aspirin, paracetamol and triptans, according to the National Institute for Health and Clinical Excellence (NICE). The watchdog estimates that one in 50 people who experience headaches are suffering because they overuse their medications.

The warning comes as the group, funded by the UK government since 2009, releases its first guideline for doctors in England and Wales on diagnosing and managing headaches. The report states that up to a million people in the UK have “completely preventable” severe headaches caused by taking too many pain pills. Some of these people are trapped in a “vicious cycle” of taking pills for pain relief, which then cause more headaches, to which they then take more pills to try to stop the headaches.

Headaches caused by medication overuse feel the same as other common headaches and migraines, the group said.

“We have effective treatments for common headache types,” said Martin Underwood, a general practitioner and professor of primary care research at Warwick Medical School. “However, taking these medicines for more than 10 or 15 days a month can cause medication overuse headache, which is a disabling and preventable disorder.”

Underwood said he hopes the new guideline will help “improve awareness of medication overuse headache both in primary care and among the general public because prevention is simple and treatment is difficult.” He noted that “explaining to patients that they should abruptly stop their medication, knowing that their headache will get much worse for several weeks before it will improve, is not an easy consultation.”

The UK has no authoritative data on the incidence of headache from medication overuse, but studies in other countries have shown 1 to 2 percent of people are affected; the World Health Organization (WHO) has put that estimate closer to 5 percent.

Experts do not know exactly why painkillers have this effect on the brain. Most people affected are believed to have had previous tension-type headaches or migraines occurring on a daily basis. And then these headaches became worse as people treated themselves at home with medication.

Manjit Matharu, a consultant neurologist at the National Hospital for Neurology and Neurosurgery, told BBC News that medication overuse was a “huge problem” in the population.

People with a family history of tension-type headaches or migraines may also be genetically more vulnerable to medication overuse headaches. They could be susceptible when taking pain relief even if it is not for headaches.

NICE said it recommends other options such as acupuncture as a means of treatment in some circumstances.

“We would expect that to lead to more people getting acupuncture, but given there is good evidence to show this is effective for the prevention of both tension-type and migraine-type headaches then that is a good thing because people are getting access to an effective treatment,” Underwood said.

NICE also urges doctors to not jump the gun and refer patients for brain scans “solely for reassurance” that they do not have a tumor. The panel said a tumor would come with other symptoms such as a change in behavior or epilepsy.

“The guideline will assist with accurate diagnosis, appropriate referral and evidence-based information for those with troublesome and disabling headaches,” said Wendy Thomas, chief executive of the Migraine Trust. “It will also raise awareness of medication overuse, which can be an issue for those with severe headaches.”

“People with disabling migraine will experience improved quality of life as a result of this guideline,” she added.

“Headache is the most prevalent condition and one in seven of the UK population has migraine,” Dr Fayyaz Ahmed, the chair of British Association for the Study of Headache, who welcomed the study, told BBC News´ James Gallagher. “The condition puts an enormous burden on the healthcare resources and the economy in general.”

“Although headache is the most common neurological problem seen by GPs and neurologists, many people are not receiving correct or timely diagnoses,” said Dr. Gillian Leng, deputy chief executive of NICE. “Our guideline outlines the assessments and treatments that people should expect to receive for primary headaches and medication overuse. We hope that this will help GPs and other healthcare professionals to correctly diagnose the type of headache disorder and better recognize patients whose headaches could be caused by their over-reliance on medications.”

The NICE guideline was developed with the help of Peter May, a long-time headache sufferer who was initially told by doctors that he was suffering from migraines.

“The pain I experience in an attack lasts around 45 minutes to an hour, and is excruciating, like being stabbed in my eye with a red hot poker,” he explained. “It took two years for me to receive a correct diagnosis, but I believe I am one of the fortunate ones as I know people who have gone 20 years” before receiving a correct diagnosis.

“There are effective treatments available but they differ according to the type of headache and so having a correct diagnosis as soon as possible is crucial,” he added.

New Laws To Protect Bolivia’s Pink River Dolphin

April Flowers for redOrbit.com – Your Universe Online

Bolivia’s only freshwater mammal – the pink river dolphin – is at risk, and now President Evo Morales has enacted a law aimed at protecting the unique animal.

The Bolivian pink dolphin (Inia boliviensis) is similar to river dolphins found in neighboring Brazil, Peru, Columbia and Venezuela. Some scientists consider the two types of Amazon river dolphins as subsets of the same species. They are often actually pink and can weigh 65 to 90 pounds.

The Bolivian pink dolphin sports a long, curved beak and uses echolocation to hunt down its prey. The animal is known to have powerful jaws with teeth proficient at crushing fish. The dolphin feeds on crustaceans, crabs, small turtles, catfish, piranha and shrimp. After killing its meal, the dolphin swallows its prey whole and regurgitates its bones later.

The new laws ban fishing, encourage programs to protect the dolphin and declare the pink dolphin a national treasure. President Morales announced this law standing on the banks of the Ibare River, calling on the armed forces to protect the habitats of the dolphin.

The biggest threats to the dolphin, known locally as “boto,” are erosion, pollution and logging in the Amazon region. An appendix to the Convention on International Trade in Endangered Species of Wild Flora and Fauna (CITES) says the species is vulnerable because of overfishing in the Amazon basin.

But the appendix says the main threat is the contamination of rivers in the region by mercury, used in illegal gold mining operations.

Evo Morales is the 80th President of Bolivia and is the leader of the nation’s socialist party. Morales has taken on an outspoken role in international climate negotiations, arguing from an indigenous perspective for greater respect for “Mother Earth.”

Bolivia’s “bolo” legislation is just the latest in wider environmentally conscious agenda.

Researchers Link Genetic Mutation To Rare Form Of Diabetes

Alan McStravick for redOrbit.com – Your Universe Online

A recent study, conducted by researchers at the Washington University School of Medicine in St. Louis and their partners at the Joslin Diabetes Center in Boston and the Novartis Institutes for Bio Medical Research, has managed to identify a specific genetic mechanism connected to mutations in the WFS1 gene that affects insulin-secreting beta cells.

It is believed that this discovery will be paramount in increasing the understanding of the rare genetic disorder Wolfram Syndrome (WS) and may also be an important development in the treatment of milder forms of diabetes and related disorders. The full study has been published online in the journal Nature Cell Biology.

Wolfram Syndrome is a rare genetic condition that is caused by mutations in a single gene. This minute mutation, however, has far reaching effects on the body leading to conditions such as diabetes, hearing and vision loss and nerve cell damage that can cause motor difficulties and, ultimately, early death.

WS was first observed in 1938 as a combination of familial juvenile-onset diabetes and optic atrophy. It was understood even then that for most of the patients with this progressive disorder, premature death and widespread atrophic changes throughout the brain were the most probable outcomes. This insulin-requiring type of diabetes typically develops at around age 6.

Examination showed that pancreatic islets were atrophic and the insulin-producing beta cells were selectively absent. WS is believed to account for 1 out of every 150 patients suffering from juvenile or adolescent onset insulin-requiring diabetes mellitus.

The mechanism by which WS works is still unknown, although in 1994 researchers discovered a link between the WFS1 gene and genetic markers on the 4p chromosome.

The reported frequency of those who carry the recessive genetic trait in the U.S. population is approximately 1%. While those that carry the recessive trait do not necessarily show the full range of WS symptoms, they are at a higher risk of developing various forms of mental illness.

Full-fledged WS only occurs in the offspring of two parents who both carry the recessive form of the gene WFS1, and multiple incidences within a genetically predisposed family are not uncommon. There doesn´t appear to be any increase or decrease in frequency based on the sex of the offspring.

As we currently understand WS, it is the result of either nuclear or mitochondrial genetic dysfunction. In addition to diabetes mellitus, other typical symptoms include diabetes insipidus, impaired vision and hearing loss. Additional WS complications can include urinary tract and seizure disorders.

Treatments for WS depend on the patient´s specific symptoms, but common treatments include therapies of thiamin and vitamin B6. With successful therapy, WS patients very often can decrease their dependence on insulin, and related complications like anemia may be eradicated entirely.

In this most recent study, led by Fumihiko Urano, associate professor of medicine at Washington University´s Division of Endocrinology, Metabolism and Lipid Research, the understanding of WS and its accompanying symptoms was greatly increased.

“We found something we didn´t expect,” said Urano. “The study showed that the WFS1 gene is crucial to producing a key molecule involved in controlling the metabolic activities of individual cells.”

The molecule referenced is called cyclic adenosine monophosphate (cyclic AMP), a naturally occurring molecule that rises in response to high blood sugar, which in turn causes insulin-secreting beta cells in the pancreas to produce and secrete insulin.

“I would compare cyclic AMP to money,” explained Urano. “You can´t just take something you make to the store and use it to buy food.  First, you have to convert it to money. Then, you use that money to buy food. In the body, external signals stimulate a cell to make cyclic AMP, and then the cyclic AMP, like money, can ℠buy´ insulin or whatever else may be needed.”

Urano went on to say that the primary reason that patients suffering from WS experience so many problems is because mutations in the WFS1 gene interfere with cyclic AMP production in beta cells in the pancreas.

“In patients with WS, there is no available WFS1 protein, and that protein is key in cyclic AMP production. Then, because levels of cyclic AMP are low in insulin-secreting beta cells, those cells produce and secrete less insulin. And in nerve cells, less cyclic AMP can lead to nerve cell dysfunction and death.”

By linking the production of cyclic AMP to mutations in the WFS1 gene, Urano´s team has given future researchers a new, more specific target for WS research.

“I don´t know whether we can find a way to control cyclic AMP production in specific tissues. But if that´s possible, it could help a great deal,” said Urano.

While WS is a rare condition, affecting only about 1 in 500,000 people, Urano says the findings also may be important in the treatment of more common disorders.

“It´s likely this mechanism is related to diseases such as type 2 diabetes. If a complete absence of the WFS1 protein causes WS, perhaps a partial impairment leads to something milder, like diabetes.”

Funding for this research was provided by the JDRF, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Center for Research Resources of the National Institutes of Health (NIH).

America On Verge Of New Level Of Fatness By 2030

Lee Rannals for redOrbit.com – Your Universe Online

The latest report by the Trust for America’s Health and the Robert Wood Johnson Foundation shows that Americans will only get fatter by 2030.

The Centers for Disease Control and Prevention (CDC) reported earlier this year that 35.7 percent of adults and 16.9 percent of children are obese, adding continued weight to the growing problem of U.S. obesity.

The latest report entitled “F as in Fat” used a model of population and other trends to determine that unless Americans change their unhealthy habits, half of U.S. adults will be obese.

The report projects that obesity rates will be at least 44 percent in every state and over 60 percent in 13 states by 2030.

Researchers from the organization said that due to the rising obesity rate by then, America will also be facing more health problems such as type 2 diabetes and endometrial cancer.

The authors project that as many as 7.9 million new cases of diabetes will be diagnosed per year, compared to 1.9 million new cases in recent years. Also, there could be as many as 6.8 million new cases of chronic heart disease and stroke every year, compared with 1.3 million new cases per year now.

A previous study published earlier this year in the American Journal of Preventive Medicine backs up the recent projections. That study found that by 2030, 42 percent of U.S. adults could be obese.

“We’re at a turning point where if we don’t do something now to mitigate these trends, the cost in human health and healthcare spending will be enormous,” Jeffrey Levi of George Washington University and the executive director of Trust for America’s Health told Reuters.

Many states in the “F as in Fat” report are projected to be more obese than others, which is due to the consideration of current state-by-state statistics.

In 2011, 12 states had an adult-obesity rate above 30 percent, with Mississippi grabbing the highest total at 34.9 percent. Colorado snagged the lowest rating at 20.7 percent.

The new report projects that by 2030, 66.7 percent of Mississippi’s population will be obese, as will 44.8 percent of Colorado’s population.

New Jersey would be facing the largest increase in costs due to the report, as its obesity rate climbs to 48.6 percent in 2030.

Some of the higher obesity-ridden states in 2030 were not as easy to predict as thought. A surprising add to the list of states with the highest obesity rate is Delaware. Currently, Delaware is in the middle of the pack when considering obesity rates, but by 2030, the authors predict it will have a rate nearly as high as Mississippi.

Not all is lost, because the report suggests some ways we can act now to prevent the U.S. from turning into a fat joke.

The report recommends adding some policies like increasing physical activity in schools and putting new standards for school meals into place in order to try and curb obesity rates from climbing.

A CDC report found recently that Philadelphia’s public school students’ obesity rate has declined in recent years. The city has implemented several initiatives over the last decade, such as removing sodas and sugary drinks, and offering breakfast for free to students.

New York City mayor Michael Bloomberg has made an attempt to cut down on sugary drink consumption around his town as well. Last week, the city’s Board of Health gave its seal of approval to Bloomberg’s plan to ban the sale of beverages larger than 16-ounces in restaurants, movie theaters, and food carts.

Mosaic Discovery In Turkey Demonstrates Cultural Influence Of Roman Empire

Lawrence LeBlond for redOrbit.com – Your Universe Online

An archaeological team from the University of Nebraska-Lincoln has unearthed a massive Roman mosaic in southern Turkey in what is being described as the largest mosaic of its type ever found in a region that was heavily influenced by the Roman Empire during the third and fourth centuries.

Professor Michael Hoff, of UNL, director of the excavation, said “Its size signals, in no small part, that the outward signs of the empire were very strong in this far-flung area“¦We were surprised to have found a mosaic of such size and of such caliber in this region — it’s an area that had usually been off the radar screens of most ancient historians and archeologists, and suddenly this mosaic comes into view and causes us to change our focus about what we think (the region) was like in antiquity.”

The 1,600 square-foot work was hand-crafted during the region´s imperial zenith.

Hoff and his colleagues have been excavating the remains of the ancient city of Antiochia ad Cragum on the southern coast of Turkey since 2005. The city was founded in the middle of the first century by Antiochus of Commagene, a client-king of Rome.

Hoff said the area is fairly new to archeology. “It’s not a place in which archaeologists have spent a lot of time, so everything we find adds more evidence to our understanding of this area of the Roman Empire.”

“We’re beginning to understand now that it was more Romanized, more in line than the rest of the Roman world than was suspected before. (The nature of the mosaic) hammers home how Roman this city truly is,” he added.

The ancient city was very typical of a Roman provincial city. It had temples, baths, markets and pillared streets, Hoff explained. Antiochia de Cragum thrived during the Roman Empire, with an economy rich in agriculture, wine and lumber.

Hoff´s excavation focused mainly on the third-century imperial temple, along with a colonnaded (pillared) street lined with shops. The mosaic, which is part of a Roman bath, was discovered in 2001, but Hoff and crew had not begun exploring it until this past July. It had large decorative tiles, each filled with colored geometric designs and ornate markings.

“This is a gorgeous mosaic, and its size is unprecedented” — so large, in fact, that work crews have uncovered only an estimated 40 percent of its total area, Hoff said.

The middle section of the mosaic was outfitted with a marble-lined, 25-foot-long pool, which was uncovered and open to the sun. The other half of the mosaic, adjacent to the bath, has yet to be revealed but is expected to contain the same type of ornate detail, Hoff explained.

The entire mosaic is expected to be uncovered by next summer.

The mosaic first came to light in 2001 when a farmer upturned a few pieces of a mosaic in a field next to a still-standing bath structure. Hoff was part of the 2001 team that witnessed the unearthing. The discovery was brought to the attention of the archaeological museum in Alanya, who, two years later, led a small investigation that revealed a small area of the mosaic.

Last year, the museum invited Hoff and his team to uncover the mosaic and preserve it for tourists and scholars. The 60-person archaeological team include researchers from University of Nebraska and others from Turkey and the US, as well as workers from a nearby village. About 35 students have participated in the summer project.

Hoff said he is eager to return next year to continue the excavations and see what else the site has to offer.

“As an archaeologist, I am always excited to make new discoveries. The fact that this discovery is so large and also not completely uncovered makes it doubly exciting“¦I am already looking forward to next year, though I just returned from Turkey,” he concluded.

Black Holes Reveal Their Origins Through Dying Tones

April Flowers for redOrbit.com – Your Universe Online

Recent research from the University of Cardiff has found that the dying tones of black holes reveal the cosmic crash that caused them to form.

Black holes are regions of space where gravity is so strong that not even light can escape. Usually, they are the evolutionary ending of stars that were 10 to 15 times larger than our sun. After these stars undergo a supernova event, sometimes the remnant will collapse in on itself, creating a singularity. Because the gravity is so strong that light can’t escape, no information comes to our scientists from the surface area, called an event horizon. Isolated dark holes don’t even emit any form of radiation.

Sometimes, though, black holes are deformed through other black holes or stars crashing into them. These deformed black holes are known to emit a new sort of radiation, called gravitational waves, which were predicted by Einstein nearly one hundred years ago.

Gravitational waves are ripples in the fabric of spacetime that travel at the speed of light, but they are extremely difficult to detect.

Europe, Japan, India and the US are building kilometer sized laser interferometers to detect these waves from colliding black holes and other cosmic events. The interferometers are sensitive to gravitational waves in roughly the same frequency range as audible sound waves, and can be thought of as a microphone to gravitational waves.

When two black holes orbit around each other, they emit gravitational waves and lose energy. Eventually, they collide to produce a black hole that is initially highly deformed with gravitational waves that come out not in one tone but in a mixture of different tones, very much like the dying tones of a ringing bell.

The frequency of the tones from a black hole depend on only two factors: the mass of the black hole and how rapidly it spins. Therefore, scientists have long believed that by detecting the spacetime ripples of a black hole and measuring their frequencies one can measure the mass and spin of a black hole without going anywhere near it.

The research team used Cardiff’s powerful ARCCA cluster to perform a large number of computer simulations of a pair of black holes crashing against each other. The results, published in Physical Review Letters, show that the different tones of a ringing black hole can actually tell us much more.

“By comparing the strengths of the different tones, it is possible not only to learn about the final black hole, but also the properties of the original two black holes that took part in the collision,” explained Ioannis Kamaretsos, who performed the simulations as part of his PhD research.

“It is exciting that the details of the late inspiral and merger are imprinted on the waves from the deformed final black hole. If General Relativity is correct, we may be able to make clear how very massive black holes in the centers of galaxies have shaped galactic evolution. We never guessed it would be possible to weigh two black holes after they’ve collided and merged,” said Dr Mark Hannam. “We might even be able to use these results to test Einstein’s general theory of relativity. We can compare the waves we observe from the orbiting black holes with the waves from the merged black hole, and check whether they are consistent.”

Professor B Sathyaprakash, who has spent his whole career studying gravitational waves commented: “It is quite remarkable. As in any new research, our finding opens up new questions: how accurately can we measure the parameters of the progenitor binary, whether our results hold good for more generic systems where initial black hole spins are arbitrarily oriented, etc. We will be addressing these questions in the coming years. Advanced gravitational wave detectors that are currently being built will provide us an opportunity to test our predictions in the coming decade.”

The team’s research opens up a new avenue of approach for studying the properties of the binary that produced the final black hole even when the binary is not visible to a gravitational wave detector. Future gravitational wave detectors should be able to study black holes far heavier than what was thought possible before and hence enhance their science reach.

Clinic-Based Programs Help Fight Obesity In Children

10 percent fewer obese after 6-month study

Could a clinic-based intervention that assists in dealing with childhood obesity be scaled down into an easily-taught, community-based program? Yes, according to a new feasibility study conducted by researchers at Temple University’s Center for Obesity Research and Education and published in the journal, Pediatrics.

Working in partnership with UnitedHealth Group and the Greater Providence YMCA, the Temple researchers conducted a six-month program on weight loss and management for 155 children and their parents or guardians in Providence, R.I.

“We’ve known for decades that there are effective treatments for childhood obesity, but they are labor-intensive, expensive and not very accessible,” said CORE Director Gary Foster, who developed the study and designed its curriculum along with a scientific advisory board. “We were interested in seeing if a clinic-based program could be diluted and implemented in the community.”

Ninety-two percent of the children who participated in the program through the YMCA were obese and almost half were at or above the 99th percentile.

“The 99th percentile basically means you’re off the charts,” said Foster. “So with almost 50 percent who participated in this study in that category, it indicates to me that there is a lot of pent up demand for these programs in the community.”

During the study, the children and their parents/guardians met in 12 face-to-face group sessions at the YMCA and in 12 home sessions in which the parents/guardians conducted a lesson based on a provided handout.

During the sessions, the children were advised on methods to limit or avoid foods such as cookies, candy, sugar sweetened beverages and fried foods.

“Each week, families were given specific goals around eating, activity and tracking progress,” said Foster.

Foster said the following week, the group would problem solve about the task: how it went, what was easy and/or tough in accomplishing it. The group also discussed increasing physical activity, getting social support for their goals and dealing with peer pressure, such as friends who are drinking soda or eating pizza.

At the end of the six-month study, the researchers found that 8 percent fewer children were at or above the 99th percentile, while 10 percent fewer were in the obese category.

“The fact that 10 percent fewer children were obese after the program is impressive,” said Foster. “If a program like this were implemented across the country, there would be 10 percent fewer obese children. That’s a huge impact with significant health and economic implications.”

Foster said the fact that none of the group facilitators involved in the study had ever treated childhood obesity before demonstrates how easily the program can be brought into the community through schools, churches and other community organizations.

“Does it work as well as if we had treated the children intensively in the clinic? No,” said Foster. “It’s about a half to two-thirds as effective. But it is more cost-efficient and more accessible to the millions of families who need help, and if you can get 10 percent of the children to not be obese as a result of this program, that’s a big success.”

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Teens Are Still Sexting, And At Alarming Rates

Lee Rannals for redOrbit.com – Your Universe Online

A new survey has shown just how outrageous “sexting” has gotten, claiming that one out of every seven Los Angeles high schoolers use their smartphone to send out the sexually-explicit text messages.

Researchers from the University of Southern California in Los Angeles say teenagers in Los Angeles were seven times more likely to be sexually active if they had admitted to sexting than those who had never engaged in the activity.

The researchers reported in the journal Pediatrics that out of the 75 percent of students who said they owned a cell phone, 15 percent said they had used it to send a “sexually explicit message or photo.” Over half of the respondents said they at least knew someone who had sexted before.

Not only were students seven times more likely to have had sex if they engaged in sexting behavior, but they were also on an increasing trend towards having unprotected sex.

“Some adolescents perceive that sexting is a safer substitute to real life sexual activity, but others suggest that sexting may be viewed as a future expectation for engaging in sexual intercourse,” the researchers wrote.

The authors said that the dangers to youth extend beyond sexual risk behaviors, and that sexting poses new and different concerns compared with other sexually explicit material.

Some of the other concerns include the ease of creation and distribution of sexts, the ability for children under the age of consent to create and distribute them, and potential child pornography charges that can be levied against sextets.

The researchers suggested that clinics, schools and cell phone based programs be developed to explain the risks associated with sexting to teens. These resources should also be made available to parents about the consequences of their child sexting, according to the authors.

They suggest parents and teachers use the latest media coverage, such as that of the published topless photos of Prince William’s wife Kate Middleton, to help break the ice and relate a bit more to teens.

Recently, an Italian gossip magazine published a 26-page spread of topless photos of Kate Middleton, the Duchess of Cambridge, despite legal action taken in France against the French magazine Closer that originally published the images.

The images include Kate reportedly sunbathing on the terrace of a secluded chateau in the south of France nude before beginning a tour of the Far East and South Pacific.

Highlighting events like this in the media to teenagers may be one way to help promote the effects of photos getting into the wrong hands. Teens who sext could have their images they published wind up online.

Artificial Tooth Enamel Makes Teeth Whiter, Prevents Tooth Decay

John Neumann for redOrbit.com – Your Universe Online
Researchers from Japan have succeeded in manufacturing an artificial tooth enamel that can be applied over existing teeth, preventing decay, making the teeth appear whiter, or even end the sensation of sensitive teeth, says Shigeki Hontsu, professor at Kinki University´s Faculty of Biology-Oriented Science and Technology in Japan.
The hard-wearing and ultra-flexible material is created from the main mineral in tooth enamel, hydroxyapatite.
“This is the world´s first flexible apatite sheet, which we hope to use to protect teeth or repair damaged enamel,” Hontsu told AFP. “Dentists used to think an all-apatite sheet was just a dream, but we are aiming to create artificial enamel,” the outermost layer of a tooth, he said earlier this month.
Researchers were able to create the film in the lab as thin as 0.00016 inches thick by firing lasers at compressed blocks of hydroxyapatite in a vacuum to make individual particles pop out.
These particles fall onto a block of salt which is heated to crystallize them, before the salt stand is dissolved in water. The film is scooped up onto filter paper and dried, after which it is robust enough to be picked up by a pair of tweezers.
“The moment you put it on a tooth surface, it becomes invisible. You can barely see it if you examine it under a light,” Hontsu continued. The sheet has a number of minute holes that allow liquid and air to escape from underneath to prevent the forming of bubbles when it is applied onto a tooth.
The only major issue, which the researchers are still perfecting, is that it takes nearly a day for the film to adhere firmly to the tooth´s surface. The film is currently transparent but it is possible to make it white for use in cosmetic dentistry.
The researchers said it will still most likely be another five years before this type of treatment could be implemented in practical dental procedures. However, once approved and perfected, the treatment will aid in covering exposed dentin, which causes sensitive teeth, but it could be used cosmetically within three years, Hontsu said.
The technology, which has been jointly developed with Kazushi Yoshikawa, associate professor at Osaka Dental University, is patented in Japan and South Korea and applications are under way in the United States, Europe and China.

Bone Loss From Alcoholism Can Be Reversed With Physical Exercise, Abstinence From Alcohol

-Alcoholism is known to cause osteoporosis, or reduced bone mineral density (BMD).
-New findings indicate that as little as eight weeks of abstinence can initiate correction of an imbalance between bone formation and resorption due to alcohol’s toxic effects.
-Physical activity can also serve as a protective factor against reduced BMD.

Osteoporosis, or reduced bone mineral density (BMD), is defined by an absolute decrease in total bone mass, caused mostly by an imbalance between osteoclastic bone resorption and osteoblastic bone formation. Reduced BMD often co-occurs with alcoholism. A study of the passage of bone formation and resorption in abstinent alcoholics has found that eight weeks of abstinence may be enough to initiate a healthier balance between the two.

Results will be published in the December 2012 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View.

“There are many reasons why alcoholics may develop reduced BMD: lack of physical activity, liver disease, and a suspected direct toxic effect of alcohol on bone-building cells,” explained Peter Malik, a senior scientist and physician at the Medical University Innsbruck, Austria as well as corresponding author for the study. “A reduced BMD carries an increased risk of fractures with all the consequences; osteoporotic fractures also put an enormous financial burden on health care systems due to high rehabilitation costs.”

“This study contributes to our understanding of various deteriorating effects of long-term consumption of high amounts of alcohol on the human body,” commented Sergei Mechtcheriakov, associate professor of psychiatry at the Medical University Innsbruck, Austria. “We can see that even bone tissue which is often — and wrongly — perceived as inert, can be affected by alcoholism. It would seem that a combination of direct toxic effects of alcohol and its metabolites on bone tissue turnover as well as life style factors, such as low physical activity, may play a significant role.”

Malik and his colleagues examined BMD in 53 male abstinent patients, 21 to 50 years of age, at an alcohol rehabilitation clinic. Blood work was drawn for various measures at baseline and after eight weeks of treatment. Study authors also used x-rays to determine BMD in the lumbar spine and the proximal right femur, as well as a questionnaire to determine levels of physical activity prior to inpatient treatment.

“We found that BMD is reduced in alcoholic men without liver disease,” said Malik. “However, the initial imbalance between bone formation and resorption seems to straighten out during abstinence. This means that an increased fracture risk could be reduced during abstinence if no manifest osteoporosis is already present. In addition, regular physical exercise seems to be ‘bone-protective’ in alcoholic patients, likely due to the fact that a dynamic strain on bone through physical activity increases the rate of bone formation and resorption, which is good for bone density.”

“This study supports the view that recovery treatment programs should contain long-term moderate physical activity regimes,” said Mechtcheriakov, “which treatment programs generally do. But the study also suggests that deficits in the musculoskeletal system, such as BMD reduction or muscular atrophy, should be taken into account during the rehabilitation. The study shows that during the first weeks of abstinence the bone metabolism is slowly improving but not fully recovered. Recovery after long-term alcoholism takes months and probably years. We need better understanding of these processes in order to be able to conceive better rehabilitation programs.”

Based on these findings, Malik recommended that patients with a longer history of alcohol abuse or dependence undergo dual-energy X-ray absorptiometry, a measurement of BMD, especially when other risk factors such as co-medication or smoking are present.

Mechtcheriakov added that even though a full recovery may take months or even years, it is important to remember that it is possible with abstinence.

“This is probably true for many other alcohol-associated diseases,” Mechtcheriakov said. “It pays to stop drinking or at least reduce alcohol consumption to the low-risk levels recommended by the National Institute on Alcohol Abuse and Alcoholism. We need a better scientific understanding of the multiple consequences of alcoholism and its associated long-term recovery processes. The latter aspect has been underestimated in alcohol research for decades. This applies also to alcohol-associated neuronal sensibility disorder, motor coordination deficits, muscular atrophy, and bone metabolism. The application of scientifically based methods to support and stimulate long-term recovery processes in post-withdrawal alcoholics can dramatically improve quality of life and rehabilitation success for this large group of patients.”

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