FDA Report Suggests Women Reassess Bone Drug Use Due To Serious Adverse Events

A new analysis of popular bone-building drugs by the US Food and Drug Administration (FDA) could prompt millions of women to rethink their use of such drugs, even though the agency fell short of issuing specific recommendations.

The FDA said doctors need to reassess which women are likely to benefit from bisphosphonates such as Fosamax, Actonel and Reclast, given the lack of concrete evidence that taking them over long periods really helps them and the possibility that they can put some women at risk for rare but severe side effects.

The FDA review, published online Wednesday in The New England Journal of Medicine (NEJM), draws concern that these so-called bone-building drugs could be causing a reverse effect on some women, leading to weaker bones and contributing to “serious adverse events,” including femoral fractures, esophageal cancer and osteonecrosis of the jaw, a painful, disfiguring crumbling of the jaw.

Although the drug safety concerns are not new, the FDA decided to perform its own systematic review on the effectiveness of bisphosphonates and its side effects after prolonged use (three to five years). The agency found that the drug offered little, if any benefit over that time, and could prompt doctors around the country to reassess prescription of such drugs.

Most doctors believe that for women with documented osteoporosis who are at very high risk for spinal fractures, the benefits far outweigh any risks. However, some women with moderate bone density and no other risk factors continue to take the drugs for years even though they offer little or no benefits.

Although the FDA didn´t issue specific guidelines for duration of use, the analysis did suggest doctors and women taking the drugs should have increased awareness of the risks of long term use.

“I think a lot of people are going to come off this drug,” Dr. Clifford J. Rosen, an endocrinologist and researcher at the Maine Medical Center Research Institute, told the New York Times.

Rosen and colleagues published an accompanying article in the NEJM offering more specifics, concluding that the women most likely to benefit from long-term use of the drugs are those who continue to have very low bone density after three to five years of treatment. Women with a history of spinal fracture or with an existing fracture also are most likely to benefit from long-term use of the drugs, the researchers concluded.

However, many women who are prescribed these bone drugs have been given a diagnosis of osteopenia, moderate to low bone density that is not low enough to be called osteoporosis. These women are unlikely to benefit from long-term use and should probably stop taking the drugs after about three years, Rosen said.

It isn´t clear how many women would be affected based on the recommendations, but many women tire of therapy and stop taking it on their own anyway, probably because of the inconvenient requirements involved, like remaining upright after taking the drugs and common side effects, including heartburn, nausea and flu-like symptoms.

Even so, Rosen and colleagues estimate that 60 to 70 percent of women who currently use the drugs are good candidates for stopping the treatments after three to five years.

After about age 30, a woman´s bones start to dissolve faster than they can be rebuilt, and after menopause she may develop thin, brittle bones that are easily broken. Bisphosphonates slow this process. The drugs are incorporated into newly formed bone and can persist there for years, long after a patient stops taking them.

The FDA recommendations are based on findings from two studies led by the University of California, San Francisco (UCSF). The first study focused on Fosamax, which is sold generically as alendronate, over a ten-year period. The second study focused on Reclast and continued for six years.

The FDA analysis showed that both studies showed significant reductions in fracture risks during the first three years of use, but little or no benefit after five years.

In the Fosamax trial, 10.6 percent of women using the drug suffered a fracture during the first three years of use, compared with 21 percent in the placebo group. But there was no benefit seen among women who continued the drug for the next five to ten years. Similar results were found in the Reclast study, according to the FDA.

The studies did not show any increased risk of serious side effects with long-term use, however. But experts said the studies simply were not large enough to detect a relatively rare adverse event. Even so, there have been numerous reports of the unusual fractures and other side effects, prompting widespread concern over the risks of long-term use. It remains unclear just how common the femur fractures are, but estimates have ranged from 1to 10 in 10,000 users.

Dennis M. Black, a professor of epidemiology and biostatistics at UCSF and the coauthor of the article that accompanied the FDA report, said women should be reassured that serious complications are rare.

“The reality is there is a lot of uncertainty in this situation,” said Black. “The FDA report was very general, and we tried to be much more specific and use evidence from the best trial available. Hopefully people who are using this drug will be reassured.”

Rosen added that even though the FDA report was vague on specific recommendations, he was pleased to see the analysis published.

“It´s a very new thing that they submit a paper to The New England Journal that presents all sides of the argument,” Rosen told Times reporter Tara parker-Pope. “I think it´s a good thing, because I´ve been on these advisory committees for years, and we get a big crowd in Washington, but the doctors never see the results.”

The FDA said additional research is needed before doctors can determine if interruption of treatments is helpful. For now, the FDA said women should be mindful of how long they have been on bisphosphonates and talk with their doctors about whether they should be continuing treatments. It has already placed a statement on bisphosphonates´ labels saying patients should be reevaluated by their doctors periodically.

Dr Beatrice Edwards, an associate professor of orthopedic surgery at the Northwestern University Feinberg School of Medicine, agreed with the FDA report and said she keeps a close eye on her patients who take bisphosphonates.

“We usually have a discussion about the benefits and risks and look at their bone density,” Edwards told ABC News. “We may give them a five-year treatment, and then take them off for one or two years.”

Women who have experienced complications from bisphosphonates, such as femoral fractures, are filing lawsuits against the drug makers. The law firm Bernstein Liebhard LLP is currently representing clients who suffered from bisphosphonate complications after long term Fosamax use. The Firm is actively filing cases on behalf of these individuals in the Superior Court of New Jersey, Atlantic County, in In re: Fosamax Litigation (No. 282 N.J. Super. Ct.).

Those who took Fosamax and sustained a femur fracture may be entitled to compensation for medical bills, pain and suffering, lost wages and other injuries. To learn more about filing a Fosamax lawsuit, visit: http://www.consumerinjurylawyers.com/.

Science Determines How NOT To Spill Your Coffee!

Michael Harper for RedOrbit.com

There are several constants in life that, no matter what, will cause us pain and heartache. Death and taxes are the notable examples, along with the way toast will always fall buttered-side down. Another one of these troublesome areas in life is the way we will always, no matter what, spill some coffee when we grab it on-the-go or carry it to our tables. The common method used to avoid spillage is to walk quickly, as if getting to the table faster will shorten our opportunity to fail.

As it turns out, some researchers have decided to put some science behind these methods in order to find out just why we will always–and I mean always–spill our coffee.

A pair of researchers at the University of California at Santa Barbara (UCSB) have investigated the physics behind a cup of coffee in motion to get a better look at why the liquid wants to leap out of the cup.

The scientists conducted their studies in a variety of vessels, from large to small, and found the source of the problem isn´t the cup or the viscosity of the liquid…it´s our gait.

The normal human gait just so happens to move at such a frequency that every step further multiplies the coffee´s wave-like back and forth motion. Changing your method or approach mid-travel to avoid such spillage could even make things worse, as it may disrupt the current flow and cause coffee chaos.

These physicists put in some due diligence, too, in what may have possibly been the tastiest research ever.

“The project was certainly fun. We just wanted to satisfy our curiosity and, given the results, to share what we learned with the scientific community through peer-reviewed literature,” said Rouslan Krechetnikov, mechanical engineer at the UCSB and author of the study, according to Ned Potter of ABC News.

By modeling both the fluid and walking dynamics and comparing these models with real-world experiments, the UCSB scientists have compiled a brief list of tips to keep the hot liquid away from your arms, shirt, wrists, table, etc.

• Don´t rush. You may think the coffee will spill less if you get it to the table more quickly, but the opposite is true. Slow down and the sloshing will too.

• Watch the cup, not the floor. You´ll spill less.

The researchers also discovered that taking off slowly and doing your best to subdue the amount of impact inflicted upon your cup (heavy steps, sudden movements, etc) will also keep more coffee in your cup rather than on the floor.

Have an unusually shaped cup? Krechetnikov suggests this might also help reduce coffee-spillage. Liquid-sloshing experiments have been used for decades to study the way fuel moves inside rockets and missiles, so as not to affect trajectory. Pulling from these studies, Krechetnikov says there are 3 possible spill-proof cup designs–“a flexible container to act as a sloshing absorber in suppressing liquid oscillations, a series of annular ring baffles arranged around the inner wall of the container to achieve sloshing suppression, or a different shape cup.”

Now, go forth, coffee drinkers, and impress your friends and family with your new walking methods and-or multi-baffled cup design! May I humbly suggest viewing this clip for suggestions on how NOT to walk with your coffee?

Oregano May Cure Prostate Cancer

A component in oregano may kill prostate cancer cells.

Dawn Mission Reveals Asteroid Vesta’s Secrets

[ Watch the Video ]

Lee Rannals for RedOrbit.com
NASA unleashed a new analysis of the giant asteroid Vesta on Thursday based on data taken by its Dawn spacecraft.
Carol Raymond, Dawn deputy principal investigator at NASA´s Jet Propulsion Laboratory, said that Dawn’s success has transformed scientists’ perspective of Vesta from a fuzzy form, into a planetary body.
She said that the asteroid formed within 2 million years after the first solids formed in the solar system.
“We know now that Vesta is the only intact planetary building block surviving from the early days in the solar system,” she said during a NASA news conference about the findings.
The findings confirm a theory that Vesta was the parent asteroid of Howardite—Eucrite—Diogenite (HED) meteorites that have been found on Earth.
These meteorites are a complex assortment of rocks, whose properties indicate that it came from an igneous process not much different from the magmatic rocks found on Earth.
Harry McSween, of the Dawn surface composition working group and the University of Tennessee, Knoxville, said Vesta’s surface is compositionally heterogenous, like HED meteorites.
He said that Dawn’s observations have convinced “most of us” that the asteroid is the HED parent body.
Vesta is unlike any other object that we have visited in our solar system, according to Vishnu Reddy, Dawn framing camera team member, Max Planck Institute for Solar System Research.
He said there is a “wide range of brightness variation” on the asteroid.  On some parts, “we see areas as bright as snow,” Reddy told the conference.
As part of what shows the age of the asteroid, the scientists said they were unable to see original crust on Vesta because it has been pulverized by impacts.
David O´Brien, Dawn participating scientist and part of the Planetary Science Institute, said Dawn has revealed a wide range of craters on Vesta, and scientists have catalogued close to 2,000 craters on the surface of the asteroid.
He said that of the 2,000 craters, the hardest craters to pick out among the images are the largest ones.
“Vesta dates back to the beginning of the solar system,” O’Brien said at the conference. “Its been recording impacts from asteroids ever since that point.”
To show the age, one crater impact known as the Rheasilvia Basin is from a 1 billion year old impact, while the Veneneia Basin is from a 2 billion year old impact.  Scientists are able to determine the age of these impacts through the global crater catalogues of impacts.
In the southern region of Vesta, there is relatively few craters found, compared to the northern region which has a very densely cratered surface.  O’Brien said that this is because the formation of the Rheasvilvia impact covered that area, essentially resurfacing the southern surface.
“An age of about 1 billion years for Rheasilvia is unexpectedly young,” NLSI team member Dr. Simone Marchi, lead author a paper published in the journal Science about the new analysis, said in a press release.
“This result has important implications for our understanding of the evolution of the Vesta, its asteroid family and the inner main asteroid belt in general. We have just started exploring Vesta’s secrets, and I’m sure other intriguing results will come along shortly.”
O’Brien also mentioned that there is 250,000 cubic miles of surface material that has ejected from this asteroid into space, which is enough to fill the Grand Canyon a thousand times over.  This also adds to the evidence that Vesta is the parent body of the HED meteorites.
Because of HED meteorites found on Earth, McSween said at the news conference that “we are now unraveling the geologic history of Vesta in ways that would not be possible without samples.”
Image 2 (below): This image, made from data obtained by NASA’s Dawn spacecraft, shows the mineral distribution in the southern hemisphere of the giant asteroid Vesta. Image credit: NASA/JPL-Caltech/UCLA/INAF/MPS/DLR/IDA [ Image Gallery ]

HPV-Positive Throat Cancer Patients Respond Better To Radiotherapy Alone Than HPV-Negative Patients

New findings from a large Danish database of cancer patients suggest that, even though the human papilloma virus (HPV) can trigger throat cancer, patients who are HPV-positive and are light smokers, or don’t smoke at all, have a good response to treatment using radiotherapy alone, without the addition of chemotherapy with its consequent toxic side-effects.

Presenting her research at the 31st conference of the European Society for Radiotherapy and Oncology (ESTRO 31) [1] today [Thursday], Dr Pernille Lassen, a resident in medical and radiation oncology and researcher at Aarhus University Hospital, Aarhus, Denmark, said that HPV-positive patients with advanced oropharyngeal cancer (cancer of the oropharynx or throat, including the soft palate and base of tongue) had significantly better control of the tumor at its primary site, disease-specific survival after five years and overall survival than patients who were HPV-negative.

Further analysis, which looked at smoking history, showed that HPV-positive patients who had a history of less than 10 pack years (one pack year is the equivalent of 20 cigarettes a day for one year) had better outcomes than HPV-negative patients and those with a smoking history of more than 10 pack years.

“We consider the present findings an important contribution to the ongoing debate on how to treat patients according to known independent prognostic factors, in this case tumor HPV-status and smoking history,” said Dr Lassen. “These findings confirm the highly significant independent influence of HPV status on tumor control and survival in advanced oropharyngeal cancer that is treated with radiotherapy alone, without chemotherapy. Our results suggest that the use of radiotherapy alone may be a safe treatment strategy in patients who are light or non-smokers, while sparing them the side-effects associated with chemotherapy. However, it is too soon to select patients for a specific treatment based on these factors; we still need more data.”

Oropharyngeal cancer is uncommon. Figures from the International Agency on Cancer show that lip and oral/pharyngeal cancers affect approximately 400,000 people worldwide each year [2]. The main causes are smoking and drinking heavily; HPV is a known trigger for the tumor, and a poor diet is also linked to an increased risk.

Dr Lassen and her colleagues investigated the outcomes of 181 patients on the Danish Head and Neck Cancer Group (DAHANCA) database, who were treated between 1992-2005 for advanced oropharyngeal cancer — cancer that has spread from the primary site to lymph nodes and beyond. The patients received accelerated radiotherapy (six fractions of radiation over five days in order to reduce the overall length of treatment) together with Nimorazole, an agent that acts as a radiotherapy sensitizer, making cancer cells more receptive to the effects of radiation. No chemotherapy was given. Samples of tumor tissue were analyzed to establish HPV status.

“Although HPV status is known to be an independent prognostic factor determining tumor control and survival in radiotherapy for head and neck cancer, it is still not clear what the best treatment is for these patients. Data from the DAHANCA randomized trials has given us the opportunity to look at a group of patients, with known HPV and smoking status, who received radiotherapy without chemotherapy,” explained Dr Lassen.

Out of the 181 patients, 103 had HPV positive tumors (57%). HPV-positive patients had better control of the tumor at its primary site (81% versus 48% of HPV-negative patients), disease-specific survival (90% versus 56%), and overall survival (77% versus 38%).

When the researchers took account of smoking history, HPV-positive, light or non-smokers, had very favorable outcomes. The probability of tumor control at its primary site was 91%, disease-specific survival was 96% and overall survival 90% five years after completion of radiotherapy. In comparison, the corresponding results for HPV-positive heavy smokers were 77%, 81% and 63% after five years.

All but two of the 78 patients with HPV-negative tumors had a smoking history of more than 10 pack years, and their outcome was significantly worse than HPV-positive patients, regardless of pack years. Disease-specific survival in this group was between 50-52%.

Several randomized trials, including the DAHANCA 19 trial, are now investigating treatment of patients according to HPV status. “This will give us important information,” said Dr Lassen. “In the meantime, we will try to identify more patients with advanced oropharyngeal cancer and known smoking status in the DAHANCA database, in order to enlarge the present cohort, making the data more robust.”

President of ESTRO, Professor Vincenzo Valentini, who is a radiation oncologist at the Policlinico Universitario A. Gemelli in Rome, Italy, commented: “This study confirms the highly significant independent influence of HPV expression on tumor control and survival in advanced oropharyngeal cancer treated with radiotherapy, with larger benefit in non-smoking patients, even in a non-chemotherapy setting. This study suggests it would be worthwhile testing the use of a moderately accelerated radiotherapy schedule as a single modality in these patients.”

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ORNL Protein Analysis Investigates Marine worm Community

Techniques used by researchers from the Department of Energy’s Oak Ridge National Laboratory to analyze a simple marine worm and its resident bacteria could accelerate efforts to understand more complex microbial communities such as those found in humans.

In a paper published in the Proceedings of the National Academy of Sciences, a multi-institutional research team analyzed the proteins found in a marine worm known as Olavius algarvensis. The worm lacks a digestive system and relies on microbes that live in its body to process its waste and provide energy. Previous research, however, had not untangled the metabolic details of this mutually beneficial, or symbiotic, relationship.

“This community is like the simplest form of the human gut,” said coauthor Nathan VerBerkmoes of ORNL. “It is a model system to understand symbiosis.”

While some complex microbial communities such as the human gastrointestinal system contain hundreds of thousands of microbes, the marine worm relies on only four to five bacteria. Understanding the simple network of relationships between the worm and its symbionts, however, still required novel techniques to analyze the functions of a whole system rather than individual parts.

“Very often, you’ll have a community that does function x,” VerBerkmoes said. “But if you try to isolate any one of those microbes out of the community and get it to do that function, one microbe alone can’t do it. Furthermore these microbes cannot be easily isolated and studied by traditional molecular approaches.”

To unravel the interactions of the worm community, an ORNL team led by VerBerkmoes used metaproteomics, a form of analysis that identifies and categorizes the proteins in an organism’s cell. Genomics, which yields the DNA sequence of an organism, can predict a cell’s behavior, whereas proteomics gives scientists a real-time snapshot of what actually happens in the cell’s metabolism.

The combination of genomics and proteomics can also help explain apparent redundancies in a system where several organisms appear at first glance to perform the same function.

“One of the key questions in metagenomic analyses of complex symbiotic consortia, including those of the human gut, is why there is so much functional redundancy,” said lead author Nicole Dubilier of the Max Planck Institute for Marine Microbiology. “Our metaproteomic analyses of the bacteria found in O. algarvensis indicate functional differences in the metabolism of two symbionts despite their genetic similarities. This appears to be a common theme in microbial communities.”

Metaproteomics provided indirect evidence for the research team’s hypotheses about the worm community’s metabolism, such as the potential use of hydrogen and carbon monoxide as energy sources. VerBerkmoes adds that while their analysis rapidly provided a broad overview of the system, the techniques do not confirm the specifics of individual protein behavior or function, which must be established via further direct biochemical studies. The research is published as “Metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use.” Coauthors include ORNL’s Jacque Young, Yun-Juan Chang and Manesh Shah, and researchers from the Max Planck Institute for Marine Microbiology, the University of Greifswald, the University of Freiburg, the Institute of Marine Biotechnology in Greifswald, and the HYDRA Institute for Marine Sciences. The project was lead by Manuel Kleiner and Nicole Dubilier from the Max Planck Institute for Marine Microbiology.

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Mini Electric Go-Kart Created By MIT Student

Lee Rannals for RedOrbit.com
A master’s student at the Massachusetts Institute of Technology (MIT) has built a miniature electric go-kart named “Chibikart” that can reach a theoretical top speed of 26 mph.
Charles Guan worked on the vehicle for three weeks, finishing the 34″ by 18″ vehicle for a total of about $1750, according to a report by Gizmodo.
He wrote on his blog about the process of building the Chibikart, giving plenty of photos and “to-do” instructions on how someone could replicate the design themselves.

The motorized vehicle features an adult-sized seat, but rollerblade-sized wheels, as well as a 32-volt lithium iron phosphate battery pack.
Guan said in the blog post that the realistic top speed of the Chibikart is 21 mph, while the theoretical top speed could be 26 mph.
Many tech blogs and news websites claim Guan’s inspiration for the project came from Mario Kart, a Nintendo video game that features Mario characters racing around a track in go-karts.  However, Guan wrote in an email to RedOrbit that the game had no role in his design.
“I’m actually not sure where it came from or who started it,” he said in the email. “In no way was Mariokart an inspiration or a factor in this design.”
He even wrote on his blog that for the design to take on characteristics of the Mario Kart video game karts, it would have to have larger wheels.
According to Guan, the idea was actually birthed during a “late-night-CADing-induced ‘This is TOTALLY a great idea'” moments.  A CAD is a computer-aided-design.
He said none of his projects, which can be found on his blog site are “complete” without a “late-night-CADing-induced” moment.
Other engineering feats that can be found on Guan’s blog site include: a shopping cart turned go-kart, an off-road-motorized skateboard called “Land-Bear-Shark”, and a quadra-copter known as “Chibicopter.”

LA BioMed’s Dr. Kalantar-Zadeh: Risk Prediction Equation For Death/End-Stage Renal Disease

Equation may provide more accurate risk prediction of death, end-stage renal disease for patients with impaired kidney function

Kamyar Kalantar-Zadeh, M.D., M.P.H., Ph.D., principal investigator at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), is the author of an invited editorial in JAMA. The editorial accompanied a study that included data from more than 1 million adults, and indicated the use of a newer risk prediction equation that classified fewer individuals as having chronic kidney disease and more accurately categorized the risk for death and end-stage renal disease.

Glomerular filtration rate (GFR) is used in the diagnosis of chronic kidney disease (CKD) and is an independent predictor of all-cause and cardiovascular mortality and kidney failure in a wide range of populations, according to background information in the article. Clinical guidelines recommend reporting estimated GFR when serum creatinine level is measured. “The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation more accurately estimates GFR than the Modification of Diet in Renal Disease (MDRD) Study equation using the same variables [age, sex, race, and serum creatinine level], especially at higher GFR, but definitive evidence of its risk implications in diverse settings is lacking,” the authors write.

Kunihiro Matsushita, M.D., Ph.D., of Johns Hopkins University, Baltimore, and colleagues conducted a study to evaluate whether estimated GFR calculated by the CKD-EPI equation predicts risk for adverse outcomes more accurately than the MDRD Study equation in a broad range of populations. The study consisted of a meta-analysis of data from 1.1 million adults (18 years of age and older) from 25 general population cohorts, 7 high-risk cohorts (of vascular disease), and 13 CKD cohorts. The participants were from 40 countries or regions of Asia,

Europe, North America and South America, the Middle East, and Oceania. Data transfer and analyses were conducted between March 2011 and March 2012. The primary adverse outcomes analyzed were all-cause mortality (84,482 deaths from 40 cohorts), cardiovascular mortality (22,176 events from 28 cohorts), and end-stage renal disease (ESRD) (7,644 events from 21 cohorts).

The prevalence of CKD stages 3 to 5 (<60 mL/min/1.73 m2) was lower by the CKD-EPI equation than by the MDRD Study equation in the general population cohorts (6.3 percent vs. 8.7 percent, respectively) and in the high-risk cohorts (14.6 percent vs. 17.7 percent).

“Overall, the CKD-EPI creatinine-based equation more accurately classified individuals with respect to risk of mortality and ESRD compared with the MDRD Study equation. Given more accurate GFR estimation, lower CKD prevalence estimates, and better risk categorization by the CKD-EPI equation without additional laboratory costs, its implementation for estimated GFR reporting could contribute to more efficient and targeted prevention and management of CKD-related outcomes.”

In an accompanying editorial, Dr. Kalantar-Zadeh and his co-author wrote that “even though CKD staging using the more conservative CKD-EPI equation seems valid because it produces more meaningful risk profiles, it is premature to conclude that the ultimate tool for estimated GFR accuracy has been found.”

“An even more conservative and accurate equation may be developed eventually, perhaps by these same investigators who first developed and advocated the MDRD equation (that is still in use in many estimated GFR laboratory reports) and who have now advanced the CKD-EPI equation to replace its MDRD predecessor. Some inherent limitations of the MDRD equation remain essentially unchanged in the CKD-EPI equation, in particular the reliance on creatinine as a single suboptimal filtration marker that not only is a close correlate of skeletal muscle mass but also probably varies with the magnitude of ingested meat and nutritional status. To date no single circulating biomarker meets the desired criteria of the ideal renal filtration marker. It is possible that a panel of several filtration markers, including cystatin C, for instance, combined with some surrogate markers of nutritional status and body composition, will provide a more accurate and clinically meaningful estimate of GFR.”

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Pacific Ocean ‘Garbage Patch’ Increasing At Alarming Rate

Brett Smith for RedOrbit.com

Plastic trash has been accumulating in the Pacific Ocean at an alarming rate and its effects are reverberating throughout the ecosystem, according to a new study by researchers at Scripps Institution of Oceanography at UC San Diego.

The  study, published in the May 9 online issue of the journal Biology Letters, found that plastic trash in the “Great Pacific Garbage Patch” has increased by 100 times over in the past 40 years.  Experts disagree over the scale of the debris zone, but some say it is twice the size of Hawaii, while other say it covers a swath of ocean the size of Texas.

“Plastic only became widespread in late ’40s and early ’50s, but now everyone uses it and over a 40-year range we’ve seen a dramatic increase in ocean plastic,” said Scripps graduate student Miriam Goldstein, lead author of the study. “Historically we have not been very good at stopping plastic from getting into the ocean so hopefully in the future we can do better.”

The effect of this plastic can be seen on the population of Halobates sericeus. Also known as ℠sea-skaters´, these insects are related to the ℠water-skaters´ or ℠water bugs´ typically seen gliding across ponds in the U.S. The sea skaters reproduce by laying their eggs on floating debris. The natural sources for these eggs, like feathers or driftwood, are being replaced by the tiny bits of plastic garbage floating on the ocean´s surface.

Ironically, the widespread availability of artificial egg-laying surfaces is driving up the population of these insects, according to researchers. In turn, this population boom will be felt all the way up the food chain, starting with the sea skaters natural predators, such as sea birds and crabs.

The garbage patch appears benefit other invertebrates as well.  Barnacles, crabs, fish that like to live under some kind of cover could be well-suited to take advantage of the garbage patch. The explosions of these populations would also have unforeseen effects of the ocean´s food chains.

“The study raises an important issue, which is the addition of hard surfaces to the open ocean,” Goldstein said.

“In the North Pacific, for example, there’s no floating seaweed like there is in the Sargasso Sea in the North Atlantic. And we know that the animals, the plants and the microbes that live on hard surfaces are different to the ones that live floating around in the water,” Goldstein told BBC News

“So, what plastic has done is add hundreds of millions of hard surfaces to the Pacific Ocean. That’s quite a profound change.”

The Garbage Patch is directly affecting other organisms besides just the sea skaters. Another Scripps report found that 9 percent of fish collected in the debris zone had ingested some form of plastic trash. The report, published in Marine Ecology Progress Series, estimated the fish at intermediate ocean depths could be ingesting plastic at a rate of roughly 12,000 to 24,000 tons per year. These fish are often eaten by larger predators, which then send the plastic trash further up the food chain.

Do You Constantly Worry About Your Cellphone? You Could Have Nomophobia

Going too long without their cellphone is something that many people fear, and that fear — labeled as nomophobia (the fear of being out of contact with someone via mobile phone)  — is on the rise, according to a study by SecurEnvoy, a company that deals in mobile phone technology.

Cellphone mobility is now a huge part of our daily lives, but for many, staying connected is becoming a huge obsession. And many, 66 percent of those surveyed, said they do have “nomophobia.” That number is an increase from a similar study four years ago, which concluded that 53 percent of people admitted they had fears of losing their cellphones.

In the recent survey, conducted using OnePoll, SecurEnvoy polled 1,000 employed people about their mobile phone usage. The survey found that 41 percent of people surveyed said they have more than one cellphone, an indication that fear of going without a cellphone is the real deal.

The poll also found that nomophobia affects women more than men — 70 percent of women surveyed compared to 61 percent of men. However, it is men who likely have more than one mobile phone — 47 percent to 36 percent, respectively. And younger people (18-24) are more nomophobic (77%) than those 25-34 years old (68%). Those 55 and older were surprisingly found to be third most nomophobic.

“I´d be inclined to draw the conclusion that, perhaps because more men have two phones, they´re less likely to misplace both and therefore be left phone-less,” said Andy Kemshall, SecurEnvoy CTO and co founder. “There is another study into mobile phone use that found people check their phones, on average, 34 times a day so it wouldn´t take long for you to realize if you´d misplaced your device.”

It is common to see problems arise due to cellphone use, according to Dr. Mitch Spero, director of child and family psychologists in Broward County, Florida. “Cellphones are tools that should be used to enhance our lives, not to destroy our interpersonal communication skills with those that we love,” he told Adam Kuperstein NBC Miami.

While the study indicates that people check their cellphones an average of 34 times per day, Karla Campos, of Pembroke Pines, said that´s nothing.

Campos, who owns web services firm Gig Logo, said she checks her phone usually 50 times per day, and even sleeps with it. “Before I go to sleep, I put it under my pillow,” she told Kuperstein.

Another surprising find of the survey: as many as 75 percent of those polled said they use their cellphones in the bathroom.

Scott Miller-Farrugia, of Coral Springs, said instead of a newspaper or magazine, he brings his cellphone to the bathroom. His wife Shellie, who is nicknamed “Celly” because of her addiction, said: “No matter where I am, it goes with me.”

But Campos takes the term “everywhere” to the extreme. She told Kuperstein that she even  takes her phone to the shower, “just in case it rings and somebody needs me.”

And she even uses the phone to communicate with her 10-year-old son, even when they are not necessarily apart. She said their conversations are deeper on Facebook — via the mobile phone.

Campos argued that any form of communication is better than none at all, and she said the cellphone is a positive way to keep connected to family.

Back to the study, Kemshall found another interesting revelation: nearly half of people surveyed said they would be upset if their messages and texts were being viewed by their partner, many of which do not use security features to keep their messages private. The survey found that 46 percent do not use any protection whatsoever, 41 percent use a four pin access code, and only 10 percent encrypt their device.

“With 58 percent of the respondents using at least one device for business use, this lack of security is a worrying trend that needs addressing,” said Kemshall.

“What this study does highlight though,” adds Kemshall “is the extent that people now rely on their mobile phones. At SecurEnvoy we have certainly seen a huge spike in demand from local government and the private sector looking to turn their staff´s phones into security devices, where they can use SMS tokenless®two factor authentication to access data securely and easily whilst on the move.”

As people are increasingly connected, nomophobia will continue to rise, becoming a mainstream issue for millions of people who need to have their phones on them, and on, at all times.

If you are constantly worried about your phone: where it is, who is using it, and if it´s on or off, you could have nomophobia.

Possible Health Consequences Resulting From Long Commutes

Connie K. Ho for RedOrbit.com

A new report in the American Journal of Preventive Medicine states that, as people move farther away from urban centers and commute longer distances via car, it can have greater health risks. In general, sedentary activity is known to have impacts on cardiovascular and metabolic health. As such, the new study finds that commuting longer distances can increase weight, decrease cardiorespiratory fitness (CRF), among other health issues.

In the experiment, researchers observed 4,297 residents who lived and worked in the Dallas-Fort Worth or Austin-Texas metropolitan areas. The participants were from 11 counties aroud these cities. The team of scientists calculated the commuting distance with ArcGIS9 software and the shortest distances from home to work with a road network. They measured the subjects´ blood pressure, body mass index (BMI), CRF, fasting triglycerides, fasting plasma glucose, high-density lipoprotein cholesterol, and metabolic risk variables like waist circumference. The participants were to self-report any physical activity they did over the three-month period of the experiment.

“This study yields new information about biological outcomes and commuting distance, an understudied contributor to sedentary behavior that is prevalent among employed adults,” commented lead investigator Christine M. Hoehner, PhD, MSPH, of Washington University in a prepared statement. “It provides important evidence about potential mediators in the relationship between time spent driving and cardiovascular mortality.”

The study found that people who had longer driving commutes to work suffered a number of things, including decreased CRF, greater BMI, larger waist circumference, higher blood pressure, and less likelihood of participating in physical activity. Specifically, people who had to commute more than 15 minutes were likely to be obese and tended to engage less in physical activity. Likewise, people who had to commute more than 10 miles showed higher blood pressure.

“I think the message for folks who live a long way from work and have a desk job is to find ways to build physical activity into their day,” commented Hoehner, in an ABC News article. “Driving to work has become a part of American life. But there’s no reason that taking walks during work breaks can’t become part of daily life, too.”

Hoehner believes that longer commutes may make people participate less in physical activity; the time that could have been spent engaging in physical activity is time spent sitting in the car.

“At the same time, both BMI and waist circumference were associated with commuting distance even after adjustment of physical activity and CRF, suggesting that a longer commuting distance may lead to a reduction in overall energy expenditure,” explained Hoehner in the statement.

Apart from commuting distance, other factors could have affected the subjects´ drive home.

“The Dallas-Fort Worth region is ranked among the top five most congested metropolitan areas, and those with longer commutes may be more likely to be exposed to heavy traffic resulting in higher stress levels and more time sitting,” remarked Hoehner in the statement.

The report also noted that driving a car is just one of the sedentary activities. The researchers didn´t take into account other factors that could affect health conditions, such as occupational sitting or watching television. Hoehner believes that further research needs to be done regarding the effect of multiple behaviors on people´s health.

“We’ve engineered physical activity out of our lives,” discussed Hoehner in the ABC News article. “We need to change our communities and make improvements to the infrastructure to make the healthy choice the easy choice.”

Other studies have found similar results, like a study done in 2011 by two Florida researchers who found that obesity was worse in states where car use was the highest.

“While it is not our intent to claim a direct causal link between transportation modes and obesity rates, it is hard to deny the existence of some geographic patterns,” explained researchers Ariel Godwin and Anne Price in a Telegraph article. “Perhaps lower rates are driven by a cumulative effect of a more affluent and educated population.”

New Way To Fight Malaria?

(Ivanhoe Newswire) —Last year it killed an estimated 655,000 people. Now researchers are developing new ways to block the transmission of Plasmodium, the parasite responsible for human malaria. Experts say the research could represent a new strategy for controlling the spread of infection.

According to the World Health Organization, more than 200 million people contract malaria each year. Experts say in order to combat the deadly disease, new tools have to be developed to prevent new infections. Wesley Van Voorhis at the University of Washington in Seattle and Oliver Billker at the Wellcome Trust Sanger Institute in Cambridge, England assembled an international research team to do just that. The researchers have discovered a new class of malaria transmission-blocking compounds that work by inhibiting a protein called bumped kinase I.

The protein is required for Plasmodium to transition to sporozoites stage, the stage in its life cycle when it is infectious to mammals. In mosquitoes that fed on blood treated with the bumped kinase inhibitor, Plasmodium sporozoite formation was blocked. Preclinical data in mice also indicated that bumped kinase inhibitors are safe and well tolerated. Research results show that bumped kinase inhibitors target a new life cycle stage in Plasmodium. Researchers suggest that the compounds merit further development as a new therapy for malaria control.

Source: Journal of Clinical Investigation, May 2012

Study Finds Americans Not Getting Enough Exercise

Researchers from a pair of prominent US universities have discovered that American adults aren’t getting enough exercise, spending less than half as much time participating in sports or fitness activities as experts recommend each week.
As part of their study, members of Penn State University and the University of Maryland analyzed data collected by the government through the Bureau of Labor Statistics’ (BLS) American Time Use Study (ATUS), the State College, Pennsylvania-based college announced in a press release Tuesday.
They found that on average, US residents only spend two hours per week participating in these types of physical activities. That statistic falls well short of Centers for Disease Control and Prevention (CDC) recommendations that adults between the ages of 18 and 64 get nearly four hours of exercise each week — 2.5 hours of moderate work, and an additional 1.25 hours of strenuous activity, including running or muscle-building exercise.
Geoffrey Godbey, professor emeritus of recreation, park and tourism management at Penn State, said, “The amount of exercise Americans get has become a major concern,” adding that there were several reasons as to why people in the US aren’t exercising as much as they should, including the fact that four out of every five miles Americans spend moving are in a vehicle, and because the society as a whole is aging.
Of course, part of the reason for the lack of activity is that Americans are simply choosing to spend their free time in different ways. In a June 2011 press release discussing the ATUS results, the BLS noted that subjects over the age of 15 watched an average of 2.7 hours of television per day. Fifteen to nineteen year olds spend more than an hour per weekend day playing computer games, while individuals over the age of 75 spent roughly the same amount of time reading on Saturdays and Sundays.
“We are almost addicted to television and computers,” Godbey said, adding that additional possible causes for the study results include the fact that “a lot of physical activities, such as hockey and tennis, can be expensive to participate in because of the gear and memberships they require,” and that “because of crime, some people are afraid to leave their homes to go out for a walk or a run.”
Walking was found to be the most prevalent physical activity, with 5% of Americans walking for an average of 53 minutes daily. Basketball was the most popular team sport, especially among teenagers, while football was second, soccer was third, then baseball, volleyball, and hockey, in order. The researchers also discovered that teenagers spend the most time exercising (41 minutes per day), followed by 18 to 64 year olds (17 minutes) and then seniors over the age of 65 (13 minutes).

Can Someone Actually Be Born To Kill?

Scientists have scanned the brains of psychopaths and have discovered they are physically different than “normal” people. The difference lies in the gray matter in the areas of the brain closely related to emotion. Psychopathic brains have less of this gray matter, according to researchers at King´s College London´s Institute of Psychiatry, meaning traditional behavioral treatment of these criminals may be missing the point.

Psychopathy is often characterized as a inability to empathize with others, especially a criminal´s victims. The King´s College team is the first to confirm psychopathy is an actual neuro-developmental sub-group of anti-social personality disorder, or ASPD.

While this isn´t the first study to reveal a physical difference in psychopathic brains, this study is the first to examine these differences among violent offenders with ASPD.

“Using MRI scans we found that psychopaths had structural brain abnormalities in key areas of their ℠social brains´ compared to those who just had ASPD. This adds to behavioral and developmental evidence that psychopathy is an important subgroup of ASPD with a different neurobiological basis and different treatment needs,” said Dr. Nigel Blackwood, lead author of the study.

“We describe those without psychopathy as ℠hot-headed´ and those with psychopathy as ℠cold-hearted´,´ Blackwood explained to the Daily Mail.

Blackwood said the “cold-hearted” psychopathic group is more likely to begin acting out violently and offending when they are younger, and will engage in a wider range of offensive behaviors. The offenders in this group are less-likely to respond well to treatment later on during adulthood when compared to the “hot-headed” group.

“We now know that this behavioral difference corresponds to very specific structural brain abnormalities which underpin psychopathic behavior, such as profound deficits in empathizing with the distress of others,” he explained.

These findings may also bring about changes in justice systems, as being able to physically identify a psychopath could strengthen defense claims of insanity.

To conduct their study, Blackwood´s team took MRI scans of 44 violent adult male offenders who have been diagnosed with ASPD.

These men had committed crimes such as attempted murder, grievous bodily harm, murder and rape. Of these men, 17 met the diagnosis for psychopathy–also known as ASPD+P– and 27 did not (ASPD-P).

As a control, the team also scanned the brains of 22 “normal” and healthy men.

They found those men with ASPD+P had significantly less gray matter volumes in the emotive sector of the brain than those with ASPD-P and healthy brains.

“Identifying and diagnosing this sub-group of violent offenders with brain scans has important implications for treatment. Those without the syndrome of psychopathy, and the associated structural brain damage, will benefit from cognitive and behavioral treatments. Optimal treatment for the group of psychopaths is much less clear at this stage,” said Dr. Blackwood in the press release.

The study has been published in the Archives of General Psychiatry.

Rare Cross River Gorilla Caught On Camera

Brett Smith for RedOrbit.com

A system of video camera traps set by the Wildlife Conservation Society (WCS) has captured evidence of the Cross River gorilla, a notoriously reclusive and endangered species of primate.

“The video represents the best images to date of Cross River gorillas, normally shy animals that flee at the slightest hint of human presence,” said WCS director Christopher Jameson.

“The footage provides us with our first tantalizing glimpses of Cross River gorillas behaving normally in their environment. A person can study these animals for years and never even catch a glimpse of the gorillas, much less see anything like this.”

One of the four cameras captured eight gorillas traveling through Cameroon´s Kagwene Gorilla Sanctuary for almost two minutes. The video shows the animals emerging from the forest and surveying the area, possibly aware of the camera´s presence. At one point, a male silverback gorilla charges past the camera while beating his chest. Another gorilla appears to be missing a hand, the possible result of a poacher´s snare.

According to the WCS, evidence of a snare-related injury should serve as both an alarm and a warning to those looking to protect these rare creatures.

“Cross River gorillas occur in very low densities across their entire range, so the appearance of a possible snare injury is a reminder that continued law enforcement efforts are needed to prevent further injuries to gorillas in the sanctuary,” said Liz Macfie, gorilla coordinator for WCS´s Species Program.

Government patrols have reduced hunting activities in the area since the establishment of the Kagwene Gorilla Sanctuary in 2008. The sanctuary, which measures almost 20 square kilometers in size and contains 20 to 30 gorillas, was created as a keystone in the effort to save the Cross River gorilla. It evolved out of the “Gorilla Guardian” network, created by WCS to improve gorilla survival prospects in the most vulnerable unprotected forest sites in Cameroon. The sanctuary is now managed by a three person staff, all appointed by Cameroon´s Ministry of Forests and Wildlife. The sanctuary also retains a team of local staff from the eight villages near the protected area. Kagwene is the only site where daily monitoring of Cross River gorilla movements takes place.

When researchers first confirmed gorilla´s presence in 2003, they quickly realized the potential of the area as a monitoring site due to the presence of a significant number of gorillas, relatively easy tracking conditions, and the interest of local communities in the gorilla´s conservation.

Cross River gorillas are considered ℠critically endangered´ and it is believed that the entire population is between 250 and 300 gorillas. They only live in the mountainous regions along the Nigeria—Cameroon border, where they exist in disjointed groups spread out over 12,000 kilometers. A 2007 genetic study and field surveys suggest that these groups are often linked by the migration of individual gorillas.

The major threats to their survival are habitat loss and poaching. While less than one percent of illegal poaching involves Great Apes, their smaller population means that they feel a greater proportional impact. The results of ape poaching also include the orphaning of younger apes, which are often illegally sold as pets.

ACCF, SCAI Publish New Standards Defining Best Practices For Modern Cardiac Cath Labs

Changes in technology, clinical practice prompt updated recommendations

Modern cardiac catheterization laboratories bear scant resemblance to the cath labs of a decade ago. An updated consensus statement released today offers physicians guidance on how to excel in this new diagnostic and therapeutic milieu, with specific recommendations on setting up, operating and maintaining the highest standards of quality in a contemporary cardiac catheterization laboratory.

The consensus statement was developed by an expert panel of the American College of Cardiology Foundation (ACCF) and the Society for Cardiovascular Angiography and Interventions (SCAI), in collaboration with the Society of Thoracic Surgeons and the Society for Vascular Medicine. It updates a similar document released in 2001.

“There have been a lot of changes since 2001, some of them dramatic,” said Thomas M. Bashore, MD, writing committee chair and professor of medicine and clinical chief of cardiology at Duke University Medical Center, Durham, NC. “This document sets the stage for what’s really happening in cath labs today and updates everyone on accepted quality standards and best practices.”

Among the changes has been a shift in focus from diagnostic tests to catheter-based therapies, from coronary disease alone to include the treatment of valvular heart disease, congenital defects of the heart and arterial disease in the legs, brain, and other organs. An increasing number of medical centers are developing hybrid cath labs that combine all the features of a surgical suite with those of a cath lab. And pediatric cath labs–now devoted almost exclusively to therapy–apply minimally invasive catheter techniques to congenital disease that once required major heart surgery, with procedures now being performed on unborn fetuses and newborns, as well as older children.

The new consensus statement addresses the features of modern cath labs, including:

Cardiac catheterization laboratories without on-site cardiac surgical back-up: Today up to one-third of angiograms (x-rays used to diagnose coronary artery disease) and percutaneous coronary interventions (PCIs) are performed in cath labs without onsite surgery. The consensus document states the risk of major complications with most invasive coronary procedures is very low and proposes requirements for establishing off-site surgical back-up while lifting many prior restrictions on the types of patients eligible for such procedures.

PCI for heart attack patients in hospitals without on-site cardiac surgical back-up: The authors stress that partnership with a major medical center with cardiac surgery capability is mandatory, including the establishment of a written plan for transfer should complications arise. The document withholds endorsement of programs that offer PCI for heart attack only during daytime business hours (no nights or weekends).

Minimum case volumes for diagnostic cardiac catheterization: The authors found no data to support the use of minimum case volumes as an indicator of physician quality in performing diagnostic cardiac catheterization. Instead, they state that an effective quality assurance program is the key to ensuring that cardiac catheterization studies are appropriate, and performed and interpreted correctly. A related document is in development and will address minimal case volume for physicians who perform PCI procedures.

Quality assurance/quality improvement programs: The new standards document defines essential elements of a quality assurance/quality improvement program, including participation in a national clinical database, tracking of specific quality indicators, benchmarking against peers, and monitoring of procedure appropriateness and quality.

Hybrid cath labs: The authors review in detail the role of the hybrid cath lab, including the types of procedures suitable for a hybrid lab and special considerations in designing, building and equipping the lab.

Training requirements: The document outlines the current training requirements for physicians who perform invasive and interventional procedures in the coronary and peripheral arteries, and for the treatment of structural heart disease.

Pre-procedural preparation: The authors recommend steps to protect kidney function during invasive procedures, including ensuring adequate hydration, shortening the time patients are instructed to go without drinking before the procedure and linking the maximum volume of contrast media to pre-catheterization kidney function tests. The document also suggests a routine protime is no longer required before the catheterization unless there is a reason to suspect an abnormality.

Imaging: The authors also summarize major changes in x-ray imaging, with the adoption of digital image acquisition, display and storage.

Radiation safety: The document outlines techniques to reduce radiation exposure to cath lab patients and staff.

Treatment of infants and children: The authors explore in depth special concerns involving the pediatric cardiac catheterization laboratory.

Consensus documents serve many purposes, but the most important is to define high-quality clinical practice, Dr. Bashore said.

“We don’t always have randomized clinical trials to rely on,” he said. “The purpose of this document is to define a practice standard for how you set up and run a cath lab, the people in the cath lab, the quality assurance programs–all the things cath lab teams should be thinking about.”

On the Net:

Anti-Malaria Garment That Wards Off Bugs

A Cornell University scientist and designer from Africa have together created a fashionable hooded bodysuit embedded at the molecular level with insecticides for warding off mosquitoes infected with malaria, a disease estimated to kill 655,000 people annually on the continent.

Though insecticide-treated nets are commonly used to drive away mosquitoes from African homes, the Cornell prototype garment can be worn throughout the day to provide extra protection and does not dissipate easily like skin-based repellants. By binding repellant and fabric at the nanolevel using metal organic framework molecules – which are clustered crystalline compounds – the mesh fabric can be loaded with up to three times more insecticide than normal fibrous nets, which usually wear off after about six months.

“The bond on our fabric is very difficult to break,” said Frederick Ochanda, postdoctoral associate in Cornell’s Department of Fiber Science & Apparel Design and a native of Kenya. “The nets in use now are dipped in a solution and not bonded in this way, so their effectiveness doesn’t last very long.”

The colorful garment, fashioned by Matilda Ceesay, a Cornell apparel design undergraduate from Gambia, debuted on the runway at the Cornell Fashion Collective spring fashion show April 28 on the Cornell campus. It consists of an underlying one-piece body suit, hand-dyed in vibrant hues of purple, gold and blue, and a mesh hood and cape containing the repellant. The outfit is one of six in Ceesay’s collection, which she said “explores and modernizes traditional African silhouettes and textiles by embracing the strength and sexuality of the modern woman.”

Ochanda and Ceesay, from opposite sides of the continent, both have watched family members suffer from the disease. Ceesay recalls a family member who was ailing and subsequently died after doctors treated her for malaria when she had a different sickness. “It’s so common back home, you can’t escape it,” Ceesay said.

“Seeing malaria’s effect on people in Kenya, it’s very important for me to apply fiber science to help this problem,” Ochanda added. “A long-term goal of science is to be able to come up with solutions to help protect human health and life, so this project is very fulfilling for me.”

Ultimately, Ceesay and Ochanda hope the outfit they developed will serve as a prototype to drive new technologies for fighting the spread of malaria. On the horizon, Ochanda said, is a fabric that releases repellant in response to changes in temperature or light — offering wearers more protection at night when mosquitoes are on the hunt. At minimum, they hope the technology can be applied to create longer-lasting insecticide-laden bed nets.

“Although there are already mosquito nets being used, the solution isn’t foolproof,” Ceesay said. “People are still getting sick and dying. We can’t get complacent. I hope my design can show what is possible when you bring together fashion and science and will inspire others to keep improving the technology. If a student at Cornell can do this, imagine how far it could go.”

Image Caption: Sandy Mattei models a design by Matilda Ceesay, a Cornell apparel design major from Gambia, at the Cornell Fashion Collective Runway Show, April 28. Credit: Mark Vorreuter

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Procedure Gives Patients With A-Fib Who Can’t Take Blood Thinners Alternative To Reduce Stroke

Northwestern’s Bluhm Cardiovascular Institute is the first in Illinois to perform this innovative procedure

Patients with atrial fibrillation (A-fib) who cannot take blood thinners now have an alternative to reduce their risk of stroke, which is five times more common in people with the rhythm disorder. The non-surgical procedure works by tying off the left atrial appendage (LAA), the source of most blood clots leading to stroke in patients with A-fib. Northwestern Medicine® heart rhythm specialists from the Bluhm Cardiovascular Institute were the first to perform this procedure in Illinois.

“Traditionally, surgery was required to close off the LAA. Now we have the ability to safely and permanently close it using a minimally invasive, non-surgical approach,” said Brad Knight, MD, medical director of the Center for Heart Rhythm Disorders at the Bluhm Cardiovascular Institute. “This is an innovative method that has the potential to revolutionize the field of stroke prevention in patients with cardiac rhythm disorders.”

The procedure, known as LAA occlusion, is performed using the FDA-approved LARIAT® Suture Delivery Device. Doctors access the LAA by inserting a catheter, or thin tube, under the rib cage into the sac around the heart through which the suture to tie off the LAA is delivered. Another catheter is advanced through a blood vessel in the groin up into the heart, and positioned inside the LAA to help guide the suture over the LAA. The outpatient procedure eliminates the number one source of heart related stroke, while avoiding the potentially serious side effects associated with blood thinners.

“We are happy to be able to give our patients another option. Non-surgical procedures mean less discomfort and a shorter recovery time,” said Albert Lin, MD, associate medical director of Cardiac Electrophysiology at the Bluhm Cardiovascular Institute. “Drug therapies have historically been the first line of defense for patients with A-fib, but they are not tolerated by all patients and can pose serious side effects for some. Now, we have the ability to safely and permanently close the LAA without the need for major surgery and potentially protect against the risk of stroke.”

A-fib is a condition where a rapid and irregular heart beat can cause serious complications, including stroke, heart failure and early death. Some people with A-fib have no symptoms and are unaware of their condition until it’s discovered during a physical examination. Those who do have A-fib symptoms may experience palpitations or sensations of a racing, irregular heartbeat, shortness of breath, chest pain or lightheadedness. A-fib related deaths have increased over the past two decades and now account for one-quarter of all strokes in the elderly.

“There has recently been a renaissance in the treatment of atrial fibrillation. This latest technological advance represents yet another novel approach to treat atrial fibrillation,” said Clyde Yancy, MD, chief of the Division of Cardiology and associate director of the Bluhm Cardiovascular Institute.

“This is a great option for patients with A-fib who are at high risk for stroke but cannot safely take blood thinners,” said Knight. “The procedure is non-invasive and the recovery time is short, so patients are able to return to their daily activities quickly.”

On the Net:

Camelops, Camelops hesternus

Camelops, an extinct genus of camel, was found in North America in places like Arizona and they first appeared there in the late Pliocene era. There are six known species in this genus. Camelops became extinct at the end of the Pleistocene era, around ten thousand years ago. The Camelops extinction was part of a larger die-off of other large animals including mastodons, horses, and camelids. The Clovis Culture, producing a burst in technology by humans, is thought to have been the cause of this mass extinction.
Because tissue is not typically preserved on fossils, it is difficult to tell if Camelops had a hump on its back, as modern camels do. One specimen of the Camelops hesternus species was found to have been around seven feet tall. Like modern camels, Camelops most likely ate whatever plants material was available, making it an opportunistic herbivore.
One specimen of an ancient camel was found at a digging site where a Wal-Mart store was to be built, giving it the name “the Wal-Mart Camel”.  A landscaping crew was digging a hole for an ornamental citrus tree when they discovered the bones of an infant and adult camel. Wal-Mart officials and John Babiarz, the owner of Greenfield Citrus Nursery whose crew found the bones, gave the remains to the Geology Museum at Arizona State University so research could be done on them. In 2008, other camel remains were found in Gilbert, Arizona.
Image Caption: Skeleton of the extinct western camel (Camelops hesternus) in the foreground, in the George C. Page Museum at the La Brea Tar Pits, Los Angeles, California. Background spotlights have been removed with Photoshop. The western camel stood seven feet tall at the shoulder, similar in size to the living Asian Bactrian camel. An American mastodon (Mammut americanum) mother and child are behind the camel. Credit: WolfmanSF/Wikipedia(CC BY-SA 3.0)

Sperm Crawl And Collide On Way To Egg

Scientists at the Universities of Birmingham and Warwick have shed new light on how sperm navigate the female reproductive tract, ‘crawling’ along the channel walls and swimming around corners; with frequent collisions.

Research results published today (Tuesday May 8, 2012) in the Proceedings of the National Academy of Sciences of the United States (PNAS) provide fresh insight into how sperm might find their way to the egg that will help to inform future innovation in the struggle to treat infertile couples.

Scientists led by Dr Petr Denissenko, of the School of Engineering at the University of Warwick, and Dr Jackson Kirkman-Brown, lead in reproductive biology at the University of Birmingham, explored what properties distinguish the tens of cells which make it to the egg from the millions of sperm cells ejaculated.

Contrary to popular belief, the authors report, sperm rarely swim in the central part of the three-dimensional female tract, instead traveling along the walls, meaning in the body they are negotiating complex and convoluted channels filled with viscous fluids.

To study cell behavior in confined space, cells were injected into hair-thin microchannels.

“When the channel turns sharply, cells leave the corner, continuing ahead until hitting the opposite wall of the channel, with a distribution of departure angles, the latter being modulated by fluid viscosity,” the reports’ authors said.

“Specific wall shapes are able to preferentially direct motile cells,” the authors report.

“As a consequence of swimming along the corners, the domain occupied by cells becomes essentially one-dimensional.

“This leads to frequent collisions and needs to be accounted for when modeling the behavior of populations of migratory cells.”

Dr Kirkman-Brown, who is also Science Lead for the Birmingham Women’s Fertility Centre, comments: “Two key questions in reproduction are:

  • How are the millions of sperm selected down to around ten that reach the oocyte?
  • Can we use a similar method to select sperm for fertility treatments?

“In basic terms — how do we find the ‘Usain Bolt’ among the millions of sperm in an ejaculate. Through research like this we are learning how the good sperm navigate by sending them through mini-mazes. ”

Dr Denissenko of the University of Warwick added: “Sperm cell following walls is one of those cases when a complicated physiological system obeys very simple mechanical rules.

“I study fluids in a variety of environments, but moving to work with live human sperm was quite a change.

“I couldn’t resist a laugh the first time I saw sperm cells persistently swerving on tight turns and crashing head-on into the opposite wall of a micro-channel.

“More seriously, it’s great being part of an internationally leading team based out of the Midlands addressing a key problem.”

Dr Kirkman-Brown concludes: “Previous research from the group indicates that the shape of the sperm head can subtly affect how the sperm swim.

“Combined with this data we believe new methods of selecting sperm, perhaps for quality or even in certain non-human species for sex may become possible.”

The researchers suggest that the combined effect of the fluid rheology and three-dimensional architecture should be taken into account in future in-vitro studies.

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AAO-HNS Releases Updated Clinical Indicators

The American Academy of Otolaryngology–Head and Neck Surgery (AAO-HNS) has released updated Clinical Indicators for the public and physicians. Clinical indicators for otolaryngology serve as a checklist for practitioners and a quality care review tool for clinical departments. The Clinical Indicators are created by the AAO-HNS and its clinical committees.
“Clinical Indicators define a basis of medical necessity for a range of procedures“¦their intent is to help practitioners engage in the best practices, reduce errors and improve value of care received as much as humanly possible,” said Richard Waguespack, MD, Coordinator for Socioeconomic Affairs and Co-Chair of the Physician Payment Policy (3P) Workgroup that led the revision effort.
“They also include procedure-specific post-operative observations, outcome issues suggested for use by institutions and surgeons, and a patient information section that physicians can use during surgical counseling.”
The newly updated indicators include: Endoscopic Sinus Surgery, Nasal Endoscopy, Canalith Repositioning, Tonsillectomy, Adenoidectomy, and Adentonsillectomy, Septoplasty, Adenoidectomy, Laryngoscope/ Nasopharyngoscopy, Endoscopic Sinus Surgery: Pediatric, and Neck Dissection. These indicators are intended as suggestions, not rules, and should be modified by users when deemed medically necessary based on clinical judgment and expertise.

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Angry Birds Maker Could Have $9 Billion Valuation

It´s the gaming phenomenon that´s leaving its mark on our generation. Its newest iteration has been download over 10 million times and it´s soon to be featured on television screens and playgrounds the world over.
It´s the Angry Birds, and they aren´t showing any sign of slowing down.
According to Reuters, Angry Birds creators Rovio Entertainment have announced sales of their popular video game have jumped “tenfold” to $100 million last year. This is enough to make for a strong stock market listing, says Rovio.
In fact, the Finnish bird-makers have been valued by analysts at $9 billion. Put in perspective, such a valuation places just shy of their neighbors, Nokia.
Rovio was initially founded in 2003, but didn´t see this kind of growth until they released the now iconic Angry Birds for Apple´s iPhone in 2009. Since then, the game has remained at the top of sales charts everywhere, selling more than 800 million copies of their games. At the end of 2011, Rovio said they had 200 million users every month. According to Reuters, that´s just shy of Zynga´s 240 million.
Tero Kuittinen from Finnish mobile firm Alekstra is impressed with Rovio´s performance.
“Rovio has fended off all rivals so far,” she told Reuters.
“Rovio is still the king of the mountain, despite stiff recent challenges by OMGPOP and Disney´s ℠Where´s My Water?´”
Rovio has said before they plan to branch out not only beyond video games, but also beyond the Angry Birds franchise. According to Chief Executive Mikael Hed, Rovio will release several such titles in the coming months.
Stronger cell phone sales, product development and branding will also help push Rovio into higher profits, says Hed.
“2012 looks fantastic,” Hed said. “We have had some very strong download numbers over four months.”
Consumer products, such as merchandising and licensing generated around 30% of Rovio´s profits last year,
With all this growth, Rovio looks poised for an initial public offering, though not until next year. When they do go public, however, the company has their eyes on either Hong Kong or New York.
“This company is preparing itself and getting ready,” said Anders Lindeberg, Rovio´s head of investor relations, saying the company is already working on meeting all of the governance requirements.
Not everyone agrees with such a large valuation, however. Writing for Forbes today, Tim Worstall admits to being the “odd one out there” and says he doesn´t see why the company should be listed so highly.
“But it is still just a game,” Worstall writes.
“One with no network effects, nothing to tie people to the platform and no real method of excluding the competition. It really is just a well executed and fun game. Something which I submit is not in fact worthy of a $9 billion valuation.”
Before taxes, Rovio reported a $48 million profit on sales of $99 million in 2011. The company did not list historic data, but has said its revenues were around $10 million in 2010.

Grow Your Own Computer?

There may be a new wave of computer technology on the way thanks to scientists at the University of Leeds and Japan´s University of Agriculture and Technology: Growing your own computer.

Magnet-making bacteria may be used to create the next generation of hard drives, making them much smaller and much faster than current models, and cells may be used to create tiny electrical bio-wires.

As the bacteria take in and digest iron, they end up creating tiny magnets inside themselves, similar to those found inside hard drives.

Living in a world which craves all things smaller, faster and quieter, computer companies and scientists alike have been trying to craft smaller components for years. Though, as the technology itself gets smaller, the task to make such nano-products has become increasingly difficult.

“We are quickly reaching the limits of traditional electronic manufacturing as computer components get smaller“¦ Nature has provided us with the perfect tool to [deal with] this problem,” Said Dr. Sarah Staniland, professor at the University of Leeds.

“Using today´s ℠top-down´ method – essentially sculpting tiny magnets out of a big magnet – it is increasingly difficult to produce the small magnets of the same size and shape which are needed to store data,” said Johanna Galloway, a Leeds PhD student who created the magnetic array used to build these micro hard drives, according to a university press statement.

“Using the method developed here at Leeds, the proteins do all the hard work; they gather the iron, create the most magnetic compound, and arrange it into regularly sized cubes.”

According to BBC News, the scientists used the bacterium Magnetospirilllum magneticum. These micro-organisms are naturally magnetic and often live in watery environments, such as lakes and ponds.

As they ingest iron, the proteins inside their bodies interact with it and produce small crystals of the mineral magnetite. This mineral is the most magnetic in the world.

The international team of researchers studied the way these microbes gather, shape and position these super-small magnets inside their bodies in order to recreate the phenomenon outside of the bacteria. Thus, the team was able to “grow” these magnets. Now, they hope these magnets will one day be used to store your photos, music and other data, according to Dr. Staniland.

Not content with magnet creating bacteria, the team was also able to create living electrical wires from other small organisms.

These wires were created by growing nano-scale tubes from cell membranes with the help of human proteins.

Just like the bacterial hard drives, these tubes may one day be used in “living” computers to transfer information just as cells communicate within our bodies.

Speaking to BBC, Dr Masayoshi Tanaka from Tokyo University of Agriculture and Technology said, “These biological wires can have electrical resistance and can transfer information from one set of cells inside a bio-computer to all the other cells.”

These wires may not only be used inside computers, but may also find some applications in human surgery, as they are highly biocompatible, according to Dr. Tanaka.

“Various tiny wires have been already developed all over the world, but the biocompatibility is still problematic,” he said. “The fabricated nano-wires in this study were covered with components of cell membrane, so theoretically they are highly biocompatible.”

“Our aim is to develop a toolkit of proteins and chemicals which could be used to grow computer components from scratch,” adds Dr Staniland.

The results of this study appears in the journal Small.

Ghrelin Can Cause Some People To Reward Themselves With Even More Food

Ever notice how celebration and overeating often go hand-in hand? Americans celebrate holidays with formidable feasts and punctuate  promotions and other happy news with plenty to eat; The proverbial fatted calf, if you will.
Now, research shows our minds could be hard-wired to chemically reward ourselves with delicious food, no matter how full we feel.
An Italian team of researchers conducted the very small study on what is called “hedonic hunger.” According to MSN, the study only involved 8 participants, and as such, the authors of the study acknowledge their findings are still in the preliminary stage.
The authors do, however, believe they have found a physiological link between indulging in foods well beyond what the body needs and a “reactive jump” in the levels of 2 key chemicals.
The first of these chemicals is ghrelin, a hormone produced in the stomach which regulates both motivation and reward. The second chemical, “2-AG” (2-arachidonoylglycerol) is involved in appetite.
“This is a very intriguing study,” said Joe Vinson, speaking to MSN. Vinson is a professor of chemistry at the University of Scranton in Pennsylvania.
“It involves the psychology of the brain, as well as biochemistry. And, yes, it´s entirely possible that this kind of chemical overriding might happen, in which the brain wants a particular kind of food even though the person is full.”
Vinson did not participate in the study.
To conduct the study, the researchers fed each of the eight participants their favorite foods and later, a less-than-favorite food of theirs of equal caloric and nutrient content. While the participants ate, the researchers measured their 2-AG and ghrelin levels. As they conducted the study, they found these levels were increased when the participants were engaged in hedonic eating, or eating their favorite foods, but not with the other, less-tasty options. The researchers say this increase suggests an activation of a chemical reward system, overriding the body´s signal that it´s had enough to eat and allowing the person to eat for sheer enjoyment rather than sustainment.
Lead Author of the study Palmiero Monteleone, MD, of the University of Naples SUN in Italy said of the study, “Hedonic hunger may powerfully stimulate overeating in an environment where highly palatable foods are omnipresent, and contribute to the surge in obesity.”
“Understanding the physiological mechanisms underlying this eating behavior may shed some light on the obesity epidemic. Further research should confirm and extend our results to patients with obesity or with other eating disorders in order to better understand the phenomenon of hedonic eating.”
According to Dr. Monteleone, the notion of “eating for fun” is relatively new. In the beginning, humans ate only to sustain themselves and prepare for long, lean seasons. Now, it appears we may be rewarding ourselves with food and eating for fun rather than survival.
The study´s results can soon be found in The Endocrine Society´s Journal of Clinical Endocrinology & Metabolism (JCEM).

Facebook Addiction Is Real

It´s easy to see how people can be addicted to social media sites like Facebook. They are incredibly easy-to-use pipelines into the lives of others. Staying connected to Facebook can feel just like being connected to actual people.

Noticing the rapid use of Facebook and reliance upon it for human connection, Doctor of Psychology Cecilie Schou Andreassen created a research project called Facebook Addiction at the University of Bergen (UiB).

An article detailing the results has been published in the journal Psychological Reports.

According to Andreassen´s study, young people are more likely to develop an addiction to the social media giant than older people. Additionally, Andreassen says those who are anxious or socially insecure are more apt to use Facebook, as these people find it easier to communicate with others behind the digital veil of social networking rather than face-to-face communication.

Women and the extroverted are also more likely to develop an addiction to Facebook, according to the new research.

The social nature of Facebook is what makes it so appealing to women, placing them at a higher risk, while the extraverted are naturally more outgoing and find the use of Facebook suited to their social needs.

Facebook has become so ubiquitous in everyday life that escaping the social media site takes more effort than using it. Since “everyone is doing it,” so to speak, it can be difficult to know if a person is truly addicted to Facebook or if they are just an avid user.

Andreassen´s study suggests the symptoms of Facebook addiction are similar to those of alcohol and drug addiction, as well as chemical abuse.

The study was based on 6 basic criteria which were scored on a scale from 1 to 5, with one meaning very rarely and 5 meaning very often.

The basic criteria were:

• You spend a lot of time thinking about Facebook or plan use of Facebook.

• You feel an urge to use Facebook more and more.

• You use Facebook in order to forget about personal problems.

• You have tried to cut down on the use of Facebook without success.

• You become restless or troubled if you are prohibited from using Facebook.

• You use Facebook so much that it has had a negative impact on your job/studies.

According to Andreassen´s study, those who answered “often” or “very often” at least 4 times are likely to be addicted to Facebook.

To conduct this study, Andreassen and team monitored the use of Facebook by 423 students-227 women and 196 men.

Addiction to Facebook is something which has been suggested for years, as users realized how easy it is to “zone out” for hours at a time looking pictures, reading comments and sharing links with one another.

Last year, writer for ZDNet.com Zack Whittaker wrote a story which associated quitting Facebook to quitting smoking, saying the first few days are the hardest, and eventually it becomes easier to stay away.

“The want and need to be open is a strange thing for the younger generation. It´s not that we no longer need to be private, but that we actively want the world to notice us in a strange, almost perverse sense of longing for attention,” writes Whittaker.

“Perhaps with the burgeoning worldwide population, we feel as if we aren´t being noticed?

Tropical Weather Systems

Tropical systems are weather features that form in the tropics and can become very intense areas of low pressure that impact many coastal regions throughout the world. They usually form between 5 and 15 latitude. This is because a tropical system is a vertical extension in the atmosphere of a large thunderstorm development. In order for these thunderstorms to move they need something in the upper levels to help them move. That is where the spinning of the earth comes into play for them which is best found at 5-15 degrees latitude. Tropical weather systems form throughout the world. There are many different names for these storms. In the United States they are known as Hurricanes. In Japan and the Western Pacific they are known as Typhoons. In India and Australia they are called Tropical Cyclones.

There are several stages of a weather systems in the tropics. The first stage is called a tropical wave. This is an area of thunderstorm development beginning to show presence. The second stage is called a tropical depression. The tropical wave is getting better organized with the cluster of thunderstorms around it. The third stage is called a tropical storm. The storm gets stronger with winds in excess of 34mph and is given a name. The fourth stage of development is called a Hurricane/Typhoon/Cyclone. The winds are very strong in excess of 74mph and the presence of an eye forms on the storm.

These storms can further intensify into what is known as Major Hurricanes or Super Typhoons when they become a  Category 3 status.

GPS And Space-based Radar Help Calculate Sierra Nevada’s Age, Growth

Researchers studying the highest mountain range in the continental United States have been able to detect the rate at which it is growing and perhaps how old the mountains that are found there using new technology from space.

The team of researchers from University of Nevada´s Geodetic Laboratory in Reno and University of Glasgow in the UK, said the Sierra Nevada mountains are steadily growing at the rate of about 1 inch every two decades across the entire 400-mile-long range on the Nevada-California border.

Though it has remained unclear in the past how or when the mountains in the region got there, the team believes that with the aid of GPS and space radar technology, they can determine just how old the Sierra Nevada range in fact is. Mt. Whitney, the Sierra´s highest peak at 14,405 feet, is growing at about 1 to 2 millimeters per year. This calculation has led the team to theorize the age of the mountain and its range at just about 3 million years old.

“There´s a surprisingly wide variety of opinions about how and why the Sierra Nevada goes up, and about the ages and timing of all the events that contribute to the uplift,” lead researcher William Hammond, a geophysicist at the University of Nevada, told Crystal Gammon of OurAmazing Planet on MSNBC.com. “These findings suggest that whatever mechanism is at play, it´s acting on the entire range.”

“The exciting thing is we can watch the range growing in real time,” Hammond said in a recent press statement. “Using data back to before 2000 we can see it with accuracy better than 1 millimeter per year. Perhaps even more amazing is that these miniscule changes are measured using satellites in space.”

Hammond and colleagues used satellite-based GPS data and InSAR (space-based radar) data to make their calculations, which show that the crust moves upward compared to Earth´s center of mass and compared to relatively stable eastern Nevada. The data could help resolve a long-standing debate on the exact age of the mountain range.

Geologists have two very different possible theories on the age of the Sierra Nevada range: the first is that the range is 40 to 80 million years old, and the second is that it is about 3 million years old.

That is a big difference, said Hammond. Either the mountains are very old and no longer growing, or they are still quite young and growing at a measurable rate.

By using GPS and InSAR, the team took microwave snapshots of the mountains and surrounding features as the satellites whizzed by overhead. The satellites revisit the same spot every month or so to take more microwave snapshots. Because it can monitor large swaths of landscape over long periods of time, InSAR data is particularly useful for measuring slow and steady changes in the shape of the Earth´s surface.

“Most of the seismic cycle is made up of periods of time where the Earth is not shaking, but it is deforming,” Hammond told Gammon. “We´re getting better at measuring that slow shape change as a way of understanding, for example, where the Earth might break in future earthquakes.”

Hammond and colleagues analyzed the Sierra´s for 18 years using the InSAR images, along with the precise measurements from GPS stations, to zero in on the growth rate. They determined that, based on their analysis of the data received, the Sierra Nevada range, with an average elevation of 6,500 to 8,200 feet, could have been built in less than 3 million years.

While the team can put a possible age on the mountain range, determining exactly how the range was built is still a mystery.

The range lies just west of the Basin and Range Province in Nevada, where east-west tectonic forces are in the process of ripping the Earth´s crust apart. Some geologists believe this stretching might be causing the eastern side of the range to grow upward.

Seismologists believe there is a heavy blob in the Earth´s mantle that may have been attached to the base of the range´s tectonic block. They think this dense blob used to weigh the block down, like a keel on the bottom of a ship. Then, sometime between 3 million and 10 million years ago, this keel peeled off and sank down deeper into the Earth, and the Sierra Nevada block popped up.

Whichever it was, Hammond said the process affected nearly the entire range and is still building up the Sierra Nevada today.

The research team includes Hammond, Geoff Blewitt, Hans-Peter Plag and Corné Kreemer from the University of Nevada; and Zhenhong Li of the Centre for the Observation and Modeling of Earthquakes, Volcanoes and Tectonics, School of Geographical and Earth Sciences, University of Glasgow in the UK.

GPS data for the research was collected through the team´s MAGNET GPS Network in Reno, and more than 1200 stations from the national Science Foundation (NSF) EarthScope Plate Boundary Observatory and more than 10,000 stations from around the entire world. The InSAR radar data came from the European Space Agency with support from NASA.

The research was funded in the US by the NSF and NASA, and in the UK by the Natural Environment Research Council. Findings of the study were published in the April 27 issue of the journal Geology.

Dinosaur Farts May Have Caused Prehistoric Warming

Brett Smith for RedOrbit.com

Dinosaurs may have had a silent, but deadly effect on their climate according to new research by scientists at two UK universities.

The study, published in the May 8 edition of Current Biology, compared the digestion-related methane production of Mesozoic-era sauropods to modern cows in an attempt to determine a possible impact as the gas ripped into their prehistoric environment.

“A simple mathematical model suggests that the microbes living in sauropod dinosaurs may have produced enough methane to have an important effect on the Mesozoic climate,” said Dave Wilkinson of Liverpool’s John Moores University. “Indeed, our calculations suggest that these dinosaurs could have produced more methane than all modern sources–both natural and man-made–put together.”

Against the backdrop of the climate change debate, many scientists have been studying the environmental impact of methane production for years. Microbes within animals´ intestinal tracts aid in the digestion of their diet and produce methane as a byproduct. These researchers have found that methane production of the microbes´ host animal is directly related to its weight.

These previous findings allowed the UK researchers to scale up the methane production of cows, which typically weigh around 1000 pounds. Based on the calculated weight of the typical sauropods , the largest weighing in at about 240 tons, they determined that methane emissions of the ancient beasts to be around 520 million tons. This compares to the estimated production of today´s cattle of between 50 and 100 million tons. Modern methane production that includes manmade sources is estimated to be around 500 million tons.

Methane is known as a “greenhouse gas” because it absorbs the sun´s radiation and the impact of these calculations means the Mesozoic climate was likely warmer because of its effects. Previous research has shown that the Earth was up to 18 degrees higher during this time.

As impressive as these calculations are, Wilkinson added that dinosaurs were not the sole producers of methane at the time.

“There were other sources of methane in the Mesozoic so total methane level would probably have been much higher,” he told BBC News.

Studies of mammalian herbivores have found that the larger animals have developed more efficient digestive processes. Food of larger herbivores tends to remain in the digestive tract longer, allowing the animals to maximize the amount of nutrients extracted from their diet. Many of these animals contain ℠fermentation chambers´ that cultivate large colonies of microbes, which assist in digestion.

The impact of methane produced by these herbivores can have a substantial impact on climate. A 2007 report published by the International Panel on Climate Change found that the 100-year global warming potential of methane is 25 times as great as that of carbon dioxide.

Researchers are currently exploring a variety of options for reducing digestion-related methane emissions from cattle and other animals. These solutions include genetic selection, diet modification and grazing management. Interestingly, cattle that eat grain produce less methane than their grazing counterparts; however greenhouse gas production is somewhat offset by pastures´ greater ability to capture CO2 as opposed to the same area used for grain production.

Yogurt-Eating Mice Have Larger Testicles

Forget red meat — a new Massachusetts Institute of Technology (MIT) study suggests that men trying to demonstrate their machismo might be better off eating yogurt.

Why, you ask? Well, according to a May 4 report by Elie Dolgin of Scientific America, the researchers discovered that mice who were fed the dairy product were found to have a type of “mouse swagger” — not to mention testicles that were approximately 5% and 15% heavier than those on typical or junk-food diets, respectively.

Furthermore, MIT cancer biologist Susan Erdman, evolutionary geneticist Eric Alm, and colleagues discovered that experiments also showed that male, yogurt-consuming mice inseminated their partners more quickly and sired more offspring than their junk food or normal diet counterparts.

Female mice also enjoyed reproductive benefits from yogurt, giving birth to larger litters and having less difficulty weaning their offspring than control rodents, Dolgin added.

“We knew there was something different in the males, but we weren´t sure what it was at first,” Erdman told ABC News reporter Katie Moisse on Monday. “You know when someone´s at the top of their game, how they carry themselves differently? Well, imagine that in a mouse.”

Erdman added that a lab technician soon discovered the, ahem, causes of their newfound swagger.

“She noticed their testicles were protruding out really far,” the researcher said. In fact, she added, “Almost everything about the fertility of those males is enhanced“¦ There were legitimate physiological differences in males fed probiotics, not just the extra sexiness.”

Of course, there were other benefits to the yogurt-centered diet as well, Dvice‘s Evan Ackerman pointed out in a Friday article. The mice were also described as having thicker, shinier coats — up to 10 times thicker than other mice, said Ackerman. Erdman told ABC News that their fur was “shockingly shiny,” and that it was one of the first things her team noticed about the yogurt-eaters.

The original purpose of the study, Dolgin said, was to follow up on the results of a previous, long-term study conducted by experts at the Harvard School of Public Health. That study, according to the Scientific America reporter, had discovered evidence suggesting that yogurt was the most effective food to eat in order to avoid age-related weight gain.

Based on this latest study, it apparently also comes with, ahem, other benefits.

“We think it´s the probiotics in the yogurt,” Alm told ABC News when asked about the reason for the changes in the four-legged subjects. “We think those organisms are somehow directly interacting with the mice to produce these effects.”

According to Moisse, “Although the study is ongoing, the fluky findings could have implications for human fertility and weight control, not to mention hair health.”

New Spray Makes You Instantly Drunk, Instantly Sober

How would you like to get instantaneously intoxicated and then return to sobriety almost as fast without the effects of nauseating hangovers? If you answered yes to that question, then there is a new product coming to market that is just for you: The WAHH Quantum Sensations device.

But, before you run to the nearest store to get your hands on this revolutionary new alcoholic sensation, you may want to hear all the details first.

The WAHH Quantum Sensations device, designed and developed by French designer Philippe Starck and Franco-American scientist David Edwards, was unveiled in Paris last week. The duo claims the tiny dosage — just 0.075 milliliters of alcohol — will get you drunk in a matter of seconds, and then, in a “harmless” manner, return you to sobriety nearly as fast.

Edwards claims that, thanks to the way the specially designed mechanism shoots the liquid into your mouth, the effect is full and instantaneous. And once the effect disappears, you will feel just as fine as you did prior to using the spray. He also noted that you can use the spray and still pass any alcohol test after the fact.

The actual product announcement promises only “the briefest lightheadedness” and “the possibility of enjoying the pleasure of alcohol without the worrying about negative consequences.” The announcement also states that the spray has 1000 times less alcohol than a regular alcoholic beverage, meaning you would literally have to spray your mouth that many times to get the full effect of just one typical drink.

“The question is how to do good without doing harm. WAHHintoxication without its adverse effects,” said Starck during the unveiling.

The product will go on sale in Europe for 20 Euros ($26 US). Each capsule will offer 21 shots.

For Edwards, a professor at Harvard University, this is not his first go-around with specialty sprays. He launched the “Whif” in 2008 — a device that lets users get the taste of foods such as chocolate and coffee without the need to actually eat or drink them. The Whif was a moderate success, with 400,000 units sold to date.

Edwards also invented the “Whaf” — an ultrasonic system that mixes different liquids to  create a cloud of flavor.

Pertaining to the WAHH, Robert Pandina, director of the Center of Alcohol Studies at Rutgers University in New Jersey, said the lightheadedness a user may feel could be a flavor-induced placebo effect.

He added that the effect is literal nonsense. “It is patently, physiologically impossible” to get intoxicated without sufficient alcohol getting to your bloodstream — something that would never happen with a bit a spray. Even if you held a whole shot of 100-proof liquor in your mouth and waited for it to be absorbed, you´d wait for hours, he told USA Today.

And no matter how you get sloshed, there is no way to get instantly sober. “There´s no such thing as a free lunch and there´s no such thing as free intoxication,” he said.

New Research Uses Nanoparticles to Deliver Antibiotics to Beneficial Bacteria

Connie K. Ho for RedOrbit.com
Researchers at the Massachusetts Institute of Technology (MIT) and Brigham and Women´s Hospital, a teaching affiliate of Harvard Medical School, recently released information that they have studied a nanoparticle to help the immune system. The nanoparticle can focus on particular infection sites with specific antibiotics. The study is published in the journal American Chemical Society´s journal ACS Nano. According to Aleks Radovic-Moreno, a MIT graduate student and lead author of the paper, this new method would help maintain the beneficial bacteria found in humans and lessen the side effects of other antibiotics.
The research team first designed the nanoparticle from a polymer capped with polyethylene glycol (PEG), which is normally found in drug delivery. PEG is particularly important as it is nontoxic and can help nanoparticles move through the bloodstream without being noticed by the immune system. The group then designed the nanoparticles to be able to switch their charge depending on their environment. The switch in the nanoparticle was activated by the acidic environment around the bacteria. This was to solve previous problems that researchers have encountered; they would attempt to activate the bacteria with a positive charge, hoping that the bacteria´s negatively charged walls would cling to the, but found that the particles were released from the body by the immune system prior to reaching the bacteria.
Apart from the PEG layer, the nanoparticles also had a pH-sensitive layer of amino acid histidine. When the pH drops from seven to six and increases in acidity, the polyhistidine molecule will gain protons, making the molecules have a positive charge. The nanoparticles will then bind to the bacteria, causing a release of the drug that´s embedded in the core of the particle. The study by the researchers delivered the antibiotic vancomycin, but it could deliver other antibiotics or mix of drugs. The antibiotics that were carried by the nanoparticles were still found to be potent, more so than traditional antibiotics that are used in acidic environments.
Researchers state that the current version of the nanoparticle releases the drugs over a one to two-day period.
“You don´t want just a short burst of drug, because bacteria can recover once the drug is gone. You want an extended release of drug so that bacteria are constantly being hit with high quantities of drug until they´ve been eradicated,” commented Radovic-Moreno in a prepared statement.
The group also hopes that, through further research, these nanoparticles that have high antibiotics will also be able to overcome bacterial resistance.
“When bacteria are drug resistant, it doesn´t mean they stop responding, it means they respond but only at higher concentrations. And the reason you can´t achieve these clinically is because antibiotics are sometimes toxic, or they don´t stay at that site of infection long enough,” remarked Radovic-Moreno in the statement.
In continuing with their research, the team is examining how negatively charged tissue cells and proteins at infection sites will affect the nanoparticles delivery of the antibiotics. They are also studying if the nanoparticles will stay in the pH-sensitive body and, if so, how long it´ll take the particles to reach the target sites.

Honoring Nurses With National Nurse Week

Connie K. Ho for RedOrbit.com

“Thank you.” These are the words you can tell a nurse this week during National Nurse Week 2012. National Nurse Week is celebrated from May 6, National Nurses Day, to May 12, modern nursing founder Florence Nightingale´s birthday.

National Nurse Week highlights the nursing profession as an art and a science, as well as the tireless amount of hours they work to serve communities. Nurses work in a variety of locations, including emergency rooms, homeless shelters, and schools, among other places. Furthermore, they take on different roles, including health educator, nurse practitioner, and nurse researcher.

“During National Nurses Week, we recognize the tremendous contributions that nurses make to keeping America healthy. As passionate advocates, leaders and innovators for better health, America´s nurses have demonstrated their commitment to meeting the public´s health care needs,” commented Kathleen Sebelius, Secretary of the Department of Health and Human Services (HHS).

This year, the theme for National Nurse Week is “Nurses: Advocating, Leading, Caring.”

“During this pivotal time in our nation´s journey to transform health care, the theme is particularly meaningful,” remarked American Nurses Association President, Karen Daley, in a statement. “We continue to advocate for a system that puts patients at the center and that emphasizes prevention and wellness.   We are identified as leaders who can improve practice environments in the Institute of Medicine´s Future of Nursing report.  We demonstrate our caring every day, not only in our interactions with patients, but by our integrity. That is why the public ranked us as the most trusted profession for honesty and ethics for the twelfth time in a Gallup survey.”

According to the Center for Disease Control and Prevention (CDC), nurses are important for helping improve patient outcomes, lowering health care costs, as well as increasing access and coordinating care in medical situations. Past studies have shown that patients have a higher chance of death, poorer health outcomes, and increased problems coupled with less satisfaction when there is a shortage of nurses on the medical staff.

To help people raise awareness, the American Nurses Association has provided a number of examples of how people can celebrate National Nurse Week. For example, community members can plan a special recognition ceremony or a ceremony to honor local nurses. As well, they can host a fundraiser and donate money to a charity to raise awareness about nurses´ role in the health care system. Lastly, nursing and health care organizations can collaborate on National Nurse Week by planning joint events.

The American Nurses Association also details the long history of National Nurse Week. It was first proposed of in 1953 and observed in 1953 from October 11 to October 16. In January 1974, the International Council of Nurses first proclaimed that May 12 would be known as “International Nurse Day.” To further that, President Richard Nixon enacted in February 1974 a week that would be designated as National Nurse Week by the White House. In 1982, both the ANA and the U.S. Congress decided to recognize May 6 as “National Recognition Day for Nurses.” The ANA Board of Directors then expanded the celebration of nurses to a week-long recognition, with May 6 to May 12 declared as National Nurses Week. In 1993, the dates of May 6 to May 12 were finally designated the permanent dates for National Nurse Week for 1994 and the years following.

Possible Way To Prevent Brain Cell Death Discovered

In a new study, a team of UK researchers have reportedly found a way to prevent brain cell death in mice — a discovery which could ultimately lead to improved treatments for Alzheimer’s, Parkinson’s, and other neurodegenerative ailments in humans.
According to BBC News Health and Science Reporter James Gallagher, scientists at the University of Leicester studied prion disease, which affects mice in much the same way as Alzheimer’s, Parkinson’s, Huntington’s and Creutzfeld-Jacob Disease (CJD). Through their observations, they learned how the build-up of incorrectly assembled or “misfolded” proteins in infected mice resulted in the death of the brain cells.
Those misfolded proteins are responsible for forming the plaque that is found in the brains of Alzheimer’s patients, as well as the Lewy bodies of those with Parkinson’s disease, Kate Kelland of Reuters added in a Sunday article. The reasons why neurons in the brain die is still not known, she said, but the scientists believe they may have found a way to prevent it from happening.
“They showed that as misfolded protein levels rise in the brain, cells respond by trying to shut down the production of all new proteins,” he wrote. “It is the same trick cells use when infected with a virus. Stopping production of proteins stops the virus spreading. However, shutting down the factory for a long period of time ends up killing the brain cells as they do not produce the proteins they actually need to function.”
Gallagher said that the research team then attempted to “manipulate the switch” which had caused the production of protein to be ceased. When they were able to keep those cells from shutting down, they prevented the brain from dying off and allowed the mice to live “significantly” longer lives as a result.
While each individual disease is linked to the production of different sets of misfolded proteins, Gallagher said that it is possible that the technique they used could be adapted to treat different but similar conditions that target and destroy brain cells.
“The fact that in mice with prion disease we were able to manipulate this mechanism and protect the brain cells means we may have a way forward in how we treat other disorders,” lead researcher Giovanna Mallucci said in a statement, according to Kelland.
Roger Morris, a Professor of Molecular Neurobiology at King’s College London, told the BBC that it was a “breakthrough in understanding what kills neurons,” and that there were “good reasons” to believe that the findings could be applied to the treatment of other neurodegenerative conditions.
Likewise, University of Bristol Professor Andy Randall called it “a fascinating piece of work,” adding that it would be “interesting to see if similar processes occur in some of the common diseases with such deposits, for example Alzheimer’s and Parkinson’s disease.”
The results of the study, which have been published in the journal Nature, raise the possibility that researchers could one day develop a single medication that could be used to treat a wide range of neurodegenerative diseases, including Alzheimer’s and Parkinson’s, Gallagher said.

Link Between ICSI Fertility Procedure, Birth Defects Discovered

Fertility injections used to help overcome male reproductive issues could increase the risks of birth defects in the children they sire, a new study published in the New England Journal of Medicine (NEJM) has discovered.

The study, which was led by researchers at the University of Adelaide’s Robson Institute, examined a total of 308,000 South Australian births over an 18-year period, and discovered that children born as a result of intracytoplasmic sperm injection (ICSI) were more likely to have birth defects than traditionally-birthed children, Telegraph Health Correspondent Laura Donnelly reported on Saturday.
ICSI, a procedure which involved a single sperm is injected directly into an egg, is typically used when prospective fathers suffer from low sperm counts or motility problems.

Donnelly said that the researchers were not able to determine whether or not the method, which is currently used in nearly half of all UK-based fertility treatments, is dangerous by itself or because males suffering from these types of reproductive problems are simply more likely to “pass on genetic anomalies” to their offspring.

No similar link to birth defects and In-Vitro Fertilization (IVF) was discovered.

“The study found the unadjusted risk of a birth defect was 5.8 per cent following natural conception, compared with 7.2 per cent for those following IVF, and 9.9 per cent for those after ICSI,” Donnelly wrote. “While there was no significant difference in the risk between IVF and natural conception, once other factors were taken into account, the risks to those born following ICSI remained significantly higher.”

“A history of infertility, either with or without assisted conception, was significantly associated with birth defects,” lead author Michael Davies, an associate professor with the University of Adelaide, told the Telegraph. “While factors associated with the causes of infertility explained the excess risk associated with IVF, the increased risk for a number of other treatments could not readily be explained by patient factors.”

On the Net:

Amish Children Less Likely To Develop Asthma, Allergies

New research from an Indianapolis-based allergist has revealed that some Amish children are less likely to suffer from asthma or allergies than other youngsters.

In his study, lead author Dr. Mark Holbreich analyzed Amish kids who were raised on rural farms in northern Indiana and found that they even have lower rates of those two ailments than Swiss children, who are widely recognized for their lack of allergy-related symptoms, Reuters reporter Kerry Grens wrote on Friday.

Dr. Holbreich polled 157 Amish families, approximately 3,000 Swiss families who lived on farms, and nearly 11,000 Swiss families who did not live on farms, all of whom had children between the ages six and twelve, Grens said. He discovered that only 5% of the Amish kids had been diagnosed with asthma, while 6.8% of farm-raised Swiss kids and 11.2% of other Swiss kids had received such a diagnosis.

“Similarly, among 138 Amish kids given a skin-prick test to determine whether they were predisposed to having allergies, only 10 kids — or seven percent — had a positive response,” the Reuters reporter added. “In comparison, 25 percent of the farm-raised Swiss kids and 44 percent of the other Swiss children had a positive test, the researchers report in the Journal of Allergy and Clinical Immunology.”

“The rates are very, very low,” Dr. Holbreich, who has reportedly been treating Amish families for 20 years and noticed during that time that very few of them seemed to have suffered allergy-related symptoms, said. He added that he and his colleagues believed that there was “something that we feel is even more protective in the Amish” than in the Swiss farming communities and that the aim of his research “is to try to find a way to prevent this allergy and asthma epidemic that western populations are facing.”

Exactly what the reason for that phenomenon is remains unclear.

Grens reported that previous research suggests that contact with cows and regular exposure to microbes could help explain why farm-raised children as a whole are less likely to develop allergies or asthma, and Dr. Holbreich believes that drinking raw cow’s milk could also be a factor.

The factor that causes greater resistance among Amish children than their Swiss counterparts remains unexplained, he told Reuters, but it is possible that it could be due to the larger-size of Amish families or the amount of time they spend outdoors or in barns in comparison to other farming families.

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Vaccine Researcher’s Death Caused By Bacterial Infection

A 25-year-old San Francisco laboratory researcher was killed last week after contracting the deadly bacteria strain which he had been studying, various media outlets have reported.

According to Victoria Colliver of the San Francisco Chronicle, the man, who was identified by officials at the medical examiner’s office as Richard Din, was employed at the Northern California Institute for Research and Education (NCIRE), a nonprofit dedicated to advancing veterans’ health research at the VA hospital, for the past six months.

Colliver reports that he died at that facility just 17 hours after falling ill due to a bloodstream infection caused by Neisseria meningitidis, a rare strain of bacterium which has been known to cause blood infections and meningitis. She reports that he had been handling the bacterium for “several weeks” prior to his passing, and that while it was “unlikely” that the infection came from a different source, the cause of death was still under investigation.

Din was helping to develop a vaccine for Neisseria meningitidis when he fell ill, Katie Moisse of ABC News reported on Friday. He was reportedly fine when he left the lab, but two hours later, he began to experience symptoms including headache, fever and chills, she added.

The next morning, the symptoms had worsened and he also had a rash, Matt O’Brien of the Contra Costa Times said. Din asked friends to drive him to the hospital, but wound up losing consciousness while in the car and did not have a pulse upon arrival.

He died that afternoon, due to “multiple organ failure caused by meningococcal infection and septic shock,” Reuters was told by San Francisco Department of Public Health spokeswoman Eileen Shields. Shields’ organization is investigation the circumstances around Din’s death, as are the Occupational Safety and Health Administration (OSHA), the California branch of OSHA, the CDC, the San Francisco VA, the news organization added.

“It’s exceedingly rare for someone to acquire a fatal infection due to the work they perform in the lab,” CDC spokesman Tom Skinner told ABC News. “When something like this happens, it’s a tragedy. We want to learn as much as we can about what happened as a way to prevent it from happening again in the future.”

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FBI Pushes for Wiretap-Friendly Social Networks

Enid Burns for RedOrbit.com

The Federal Bureau of Investigation (FBI) has drafted a controversial proposal that would require social networking sites, VoIP services and other online platforms to build a wiretap-friendly back door. The government organization is making the rounds to social networking companies including Microsoft, Facebook, Yahoo and Google to urge them not to oppose the proposal.

In a time when more lines of communication are open, such as instant messenger, social networking sites and Voice Over Internet Protocol (VoIP), the FBI worries it won’t have access to communications between suspicious individuals. A ZDNet article states that “The FBI General Counsel’s office has drafted a proposed law that the bureau claims is the best solution: requiring that social-networking Web sites and providers of VoIP, instant messaging, and Web e-mail alter their code to ensure their products are wiretap-friendly.”

The proposal hopes to amend the 1994 Communications Assistance for Law Enforcement Act, or CALEA. CALEA requires telecommunications providers to provide the tools for an easily implemented wiretap. In 2004 the Federal Communications Commission extended CALEA to encompass broadband networks.

In defense of the original CALEA enacted in October of 1994, the FCC says it was intended to preserve the ability of “law enforcement agencies to conduct electronic surveillance by requiring that telecommunications carriers and manufacturers of telecommunications equipment modify and design their equipment, facilities and services to ensure that they have the necessary surveillance capabilities.”

The law includes common carriers, facilities-based broadband internet access providers, and providers of interconnected VoIP service. The agency fears a “Going Dark” trend. Going Dark is a term the FBI revealed in early 2011 to describe how new technologies and rapidly changing communications modes erode the ability of the government to conduct court ordered intercepts of wire and electronic communications.

Sources say the FBI has held meetings with Yahoo, Google, Microsoft and Facebook as well as the White House and U.S. Senators to discuss the proposal. In talks with internet companies, the FBI reportedly urged companies not to oppose the action.

Many social networking companies already comply to law enforcement actions, to a degree. The “safety center” page on Facebook states the conditions under which it cooperates with law enforcement authorities within the U.S. and international jurisdictions.

In the U.S., Facebook complies to the federal Stored Communications Act (SCA). Under this act the social network complies with federal and law enforcement requests with a valid subpoena issued in connection with an official criminal investigation; a court order issued under 18 U.S.C Section 3703(d); or a search warrant issued under the procedures described in the Federal Rules of Criminal Procedure.

Recent actions by the FBI to combat cyber threats and terrorist attacks include the investigation into anonymous bomb threats at the University of Pittsburgh last month, which resulted in the seizure of servers used by a remailer to mask the origin and identity of a sender and the discovery that municipal systems were under attack by hackers.

Compliance with the proposal, if it goes through, will take effect when an online service reaches a certain minimum of users. This means that smaller social networking sites or VoIP networks won’t be subject to provide code on their services that grants an easy backdoor wiretap for the FBI. That’s according to a source that spoke to ZDNet.

The FCC is reportedly behind the proposal. The agency would further the scope of CALEA to encompass any voice or video chat service on the internet.

While the proposal would grant a broad surveillance capability on the FBI and other law enforcement organizations, the agency doesn’t have the resources or the need to monitor all activities on social networks, VoIP services and other internet platforms. The FBI will use the service to conduct targeted surveillance.

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Low Oxygen Levels Could Drive Cancer Growth

Low oxygen levels in cells may be a primary cause of uncontrollable tumor growth in some cancers, according to a new University of Georgia study. The authors’ findings run counter to widely accepted beliefs that genetic mutations are responsible for cancer growth.

If hypoxia, or low oxygen levels in cells, is proven to be a key driver of certain types of cancer, treatment plans for curing the malignant growth could change in significant ways, said Ying Xu, Regents-Georgia Research Alliance Eminent Scholar and professor of bioinformatics and computational biology in the Franklin College of Arts and Sciences.

The research team analyzed samples of messenger RNA data–also called transcriptomic data–from seven different cancer types in a publicly available database. They found that long-term lack of oxygen in cells may be a key driver of cancer growth. The study was published in the early online edition of the Journal of Molecular Cell Biology.

Previous studies have linked low oxygen levels in cells as a contributing factor in cancer development, but not as the driving force for cancer growth. High incidence rates of cancer around the world cannot be explained by chance genetic mutations alone, Xu said. He added that bioinformatics, which melds biology and computational science, has allowed researchers to see cancer in a new light. Gene-level mutations may give cancer cells a competitive edge over healthy cells, but the proposed new cancer growth model does not require the presence of common malfunctions such as a sudden proliferation of oncogenes, precursors to cancer cells.

“Cancer drugs try to get to the root–at the molecular level–of a particular mutation, but the cancer often bypasses it,” Xu said. “So we think that possibly genetic mutations may not be the main driver of cancer.”

Much of cancer research so far has focused on designing drug treatments that counteract genetic mutations associated with a particular type of cancer. In their study, the researchers analyzed data downloaded from the Stanford Microarray Database via a software program to detect abnormal gene expression patterns in seven cancers: breast, kidney, liver, lung, ovary, pancreatic and stomach. The online database allows scientists to examine information from microarray chips, which are small glass slides containing large amounts of gene material.

Xu relied on the gene HIF1A as a biomarker of the amount of molecular oxygen in a cell. All seven cancers showed increasing amounts of HIF1A, indicating decreasing oxygen levels in the cancer cells.

Low oxygen levels in a cell interrupt the activity of oxidative phosphorylation, a term for the highly efficient way that cells normally use to convert food to energy. As oxygen decreases, the cells switch to glycolysis to produce their energy units, called ATP. Glycolysis is a drastically less efficient way to obtain energy, and so the cancer cells must work even harder to obtain even more food, specifically glucose, to survive. When oxygen levels dip dangerously low, angiogenesis, or the process of creating new blood vessels, begins. The new blood vessels provide fresh oxygen, thus improving oxygen levels in the cell and tumor and slowing the cancer growth–but only temporarily.

“When a cancer cell gets more food, it grows; this makes the tumor biomass bigger and even more hypoxic. In turn, the energy-conversion efficiency goes further down, making the cells even more hungry and triggering the cells to get more food from blood circulation, creating a vicious cycle. This could be a key driver of cancer,” Xu said.

Xu explained that this new cancer-growth model could help explain why many cancers become drug resistant so quickly–often within three to six months. He stressed the importance of testing the new model through future experimental cancer research. If the model holds, researchers will need to search for methods to prevent hypoxia in cells in the first place, which could result in a sea change in cancer treatment.

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How To Get A Good Night’s Sleep: Earplugs In The Intensive Care Unit Ward Off Confusion

Patients in an intensive care unit (ICU) often become confused or delirious soon after, or within a few days of, admittance to the ICU. New research published in BioMed Central’s open access journal Critical Care shows that use of earplugs can result in better sleep (as reported by the patients), lower the incidence of confusion, and delay the onset of cognitive disturbances.

Patients in the ICU are thought to suffer confusion and delirium due to sensory overload. Part of this is due to the physical injuries and sensations of the patients and part due to their environment.

Sound in the ICU has been a subject of research for several years. There is contestant noise due to equipment and people coming and going. However, patients complain that it’s not so much the level of noise but the interruptions due to phones ringing and people talking which is the most disturbing. Not surprisingly studies have shown that the sleep of patients in ICU is severely fragmented with a corresponding lack of slow wave and REM sleep.

While it is not practicable to have silent equipment (and patients need checking at regular intervals), researchers from the University of Antwerp and Antwerp University Hospital investigated the use of earplugs to reduce the amount of noise experienced by the patients as they slept.

As a result of this simple solution the researchers found that starting to use earplugs within the first 24 hours of entering ICU decreased the patient’s risk for delirium or confusion by over 50%. They also noticed that patients sleeping with earplugs developed confusion and delirium later than patients without. After the first night more of the patients with earplugs reported a better night’s sleep.

Prof Bart van Rompaey, who led this study, explained, “The greatest improvement was observed in the risk of confusion, and seems to be strongest within the first 48 hours of admittance to the ICU. Delirium is a multifactorial process and, in our study, was also influenced by age, smoking, and severity of disease. Nevertheless the beneficial effect of earplugs in the ICU, especially in the first few days, clearly demonstrates the advantage of using them. Earplugs are a cheap and easy to use means of improving a patients sleep and preventing confusion.”

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Global Warming’s Impact On Plants Greater Than Predicted

Jason Farmer for RedOrbit.com

For over two decades, researchers have been conducting experiments that are designed to mimic the effects of rising temperatures on the rates at which plants first begin to leaf and flower each spring. However, a new study has found that that these models are inaccurate, and that the actual impact of global warming on plants may cause the flowering and leafing of plants to occur up to eight times faster than the models predicted.

For many years, researchers assumed that plants would respond in much the same way in experiments that simulate global warming as they would to changes in temperature occurring in the natural environment. To test this assumption, Dr Elizabeth Wolkovich, of the University of British Columbia in Vancouver, and her colleagues compared the data on the timing of the flowering and leafing of plants found in observational studies to data based on warming experiments.

Dr Wolkovich and her colleagues were surprised by the results.

“What we found is that the experiments don´t line up with the long term data, and in fact they greatly underestimate how much plants change their leafing and flowering with warming,” Wolkovich told BBC News.

Observational data is gathered by the long term systematic recording of flowering and leafing rates in the natural world. According to Dr Wolkovich, the recent research suggests that these observations carried out in many different parts of the world over the past three decades are in remarkable agreement.

“In terms of long term observations, the records are very coherent and very consistent and they suggest for every degree Celsius of warming we get we are going to get a five- to six-day change in how plants leaf and flower.”

The researchers have concluded that scientists have greatly underestimated the difficulty of mimicking the impacts of the natural world in an artificial setting where the warming experiments are conducted. Real world factors not only include changes in temperature, but also changes in precipitation, cloud patterns and other unpredictable variables.

“I guess we will never get to perfectly match nature, but I am hopeful as scientists we can do much, much better, given funding resources,” Wolkovich told BBC News.

The team found that the greater investment in the design and monitoring of experiments, the more accurate the result.

Several other researchers were also surprised by the results.

Dr This Rutishauser, at the Oeschger Centre for Climate Change Research at the University of Bern in Switzerland, says based on this new research, scientists will have to rethink the impacts of global warming.

“The bottom line is that the impacts might be bigger than we have believed until now. That’s going to provoke a lot of work to probably revise modeling results for estimations of what’s going to happen in the future for food production especially.”

Dr Wolkovich has also concluded that if the models so grossly underestimate the real world observations, there could be a much greater impact on the world´s water supply than had been predicted by the artificial warming experiments.

“If a whole plant community starts growing a week earlier than we expect according to these experiments, it’s going to take up a lot more water over the growing season and if you add to that many years of the model projections, you are going to see big changes in the water supply.”

2010 Chile Earthquake Had Surprising Ecological Effects

Long-forgotten coastal habitats reappeared, species unseen for years returned

The reappearance of long-forgotten habitats and the resurgence of species unseen for years may not be among the expected effects of a natural disaster.

Yet that’s exactly what researchers found in a study of the sandy beaches of south central Chile, after an 8.8-magnitude earthquake and devastating tsunami in 2010.

Their study also revealed a preview of the problems wrought by sea level rise–a major symptom of climate change.

In a scientific first, researchers from Southern University of Chile and the University of California, Santa Barbara (UCSB) were able to document the before-and-after ecological impacts of such cataclysmic occurrences.

A paper appearing today in the journal PLoS ONE details the surprising results of their study, pointing to the potential effects of natural disasters on sandy beaches worldwide.

The study is said to be the first-ever quantification of earthquake and tsunami effects on sandy beach ecosystems along a tectonically active coastal zone.

“So often you think of earthquakes as causing total devastation, and adding a tsunami on top of that is a major catastrophe for coastal ecosystems,” said Jenny Dugan, a biologist at UCSB.

“As expected, we saw high mortality of intertidal life on beaches and rocky shores, but the ecological recovery at some of our sandy beach sites was remarkable.

“Plants are coming back in places where there haven’t been plants, as far as we know, for a very long time. The earthquake created sandy beach habitat where it had been lost. This is not the initial ecological response you might expect from a major earthquake and tsunami.”

Their findings owe a debt to serendipity.

The researchers were knee-deep in a study supported by FONDECYT in Chile and the U.S. National Science Foundation’s (NSF) Santa Barbara Coastal Long-Term Ecological Research (LTER) site of how sandy beaches in Santa Barbara and south central Chile respond, ecologically, to man-made armoring such as seawalls and rocky revetments.

By late January, 2010, they had surveyed nine beaches in Chile.

The earthquake hit in February.

Recognizing a unique opportunity, the scientists changed gears and within days were back on the beaches to reassess their study sites in the catastrophe’s aftermath.

They’ve returned many times since, documenting the ecological recovery and long-term effects of the earthquake and tsunami on these coastlines, in both natural and human-altered settings.

“It was fortunate that these scientists had a research program in the right place–and at the right time–to allow them to determine the responses of coastal species to natural catastrophic events,” said David Garrison, program director for NSF’s coastal and ocean LTER sites.

The magnitude and direction of land-level change resulting from the earthquake and exacerbated by the tsunami brought great effects, namely the drowning, widening and flattening of beaches.

The drowned beach areas suffered mortality of intertidal life; the widened beaches quickly saw the return of biota that had vanished due to the effects of coastal armoring.

“With the study in California and Chile, we knew that building coastal defense structures, such as seawalls, decreases beach area, and that a seawall results in the decline of intertidal diversity,” said lead paper author Eduardo Jaramillo of the Universidad Austral de Chile.

“But after the earthquake, where significant continental uplift occurred, the beach area that had been lost due to coastal armoring has now been restored,” said Jaramillo. “And the re-colonization of the mobile beach fauna was underway just weeks afterward.”

The findings show that the interactions of extreme events with armored beaches can produce surprising ecological outcomes. They also suggest that landscape alteration, including armoring, can leave lasting footprints in coastal ecosystems.

“When someone builds a seawall, beach habitat is covered up with the wall itself, and over time sand is lost in front of the wall until the beach eventually drowns,” said Dugan.

“The semi-dry and damp sand zones of the upper and mid-intertidal are lost first, leaving only the wet lower beach zones. This causes the beach to lose diversity, including birds, and to lose ecological function.”

Sandy beaches represent about 80 percent of the open coastlines globally, said Jaramillo.

“Beaches are very good barriers against sea level rise. They’re important for recreation–and for conservation.”

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Marsh Rabbit, Sylvilagus palustris

The marsh rabbit (Sylvilagus palustris), is found in the coastal and marsh covered regions of the eastern and southern United States. It is sometimes called the marsh hare. This rabbit has three subspecies, and the range for them is small. The Carolina marsh rabbit (Sylvilagus palustris palustris) inhabits mainland areas. The Florida marsh rabbit (Sylvilagus palustris paludicola) inhabits the peninsula regions of Florida, but is not found along a northern area of the Miami coast. Only found in the Florida Keys, the Lower Keys marsh rabbit is an endangered species.

The marsh rabbit, inhabiting such damp areas, has been associated with the swamp rabbit although they are not the same. Research done on the DNA of both the marsh rabbit and the swamp rabbit show that they descended from a common ancestor, but are separate species. The marsh rabbit is only found near water, and it is skilled in swimming. They choose to make their homes near freshwater and brackish areas, typically those with cattails and cypress. Florida rabbits prefer sandy areas like the mangrove forests. Unlike most rabbits, they must have close access to water.

Small in size and similar to the eastern cottontail rabbit in appearance, the marsh rabbit has key differences from the eastern cottontail. The tail, legs, and ears are all smaller than that of the eastern cottontail rabbit. They are usually smaller than eastern cottontails, and marsh rabbits from the Florida peninsula have an average weight between 2.2 and 2.6 pounds. These rabbits can be as long as seventeen inches.  Typically, mainland adult rabbits grow to be 17.5 inches in length, and have an average weight of 3.5 pounds. Compared with the hind feet of peninsular marsh rabbits, mainland marsh rabbits have larger feet with a length of up to 3.6 inches.

Depending on the location, the fur of the marsh rabbit can vary in color. Most have darker red or burnished black fur on the back, while the underside is a muted greyish brown. Some of the back fur may be edged with black, which can change to a dull grey during the warmer months of spring and summer. The belly of mainland rabbits can become faded white in color. The ears on marsh rabbits have small black tufts, with a buff color on the inside. Marsh rabbits inhabiting the peninsular regions of Florida usually have darker red fur tinged with brown on the nape, legs, and feet.

There are a few differences in marsh rabbits that make them easily distinguishable from swamp rabbits and eastern cottontails.  The marsh rabbit’s tail is typically darker in color than the white tails of other cottontail rabbits, displaying a brownish grey in color. Some rabbits in Florida display melanism, the condition in which dark colored pigments in the skin develop too soon. The black fur of these rabbits does not change color with the seasons.

The diet of the marsh rabbit consists of plant material, and they are strictly herbivores. They are known to eat bulbs and leaves of marsh plants like rushes, grasses, and cattails, but they can also eat plants under water such as greenbriar vine, centella, water hyacinth, potato, amaryllis, and marsh pennywort. Marsh rabbits will also eat their own feces, a process known as coprophagy, in order to retrieve extra nutrients. This trait is shared with cottontail rabbits. Since rabbits lack the ability to ruminate, or regurgitate food matter to gain more nutrients, they will eat their own soft pellets known as cecal pellets. Due to the rabbit’s diet of plants, they are considered to be minor pests of crops that could be viable resources. In Florida, marsh rabbits are known pests of sugar cane fields.

The marsh rabbit is typically active at night, preferring to hide in hollow logs, groups of cattails, grasses, and dense thickets during the day. Abandoned burrows are also hiding places for these rabbits. Marsh rabbits will make trails through vegetation adjacent to marsh edges to travel, and they can recognize these trails easily by marking them with pellets. Marsh rabbits prefer to walk on all fours, unlike other rabbits, but are capable of hopping. Another oddity of marsh rabbits not found in other rabbits are the widely spread toe marks left from their tracks. Their gait has been measured at 3.5 to 6.5 inches between steps.

Because they do not inhabit forested areas, marsh rabbits take to water more easily than swamp rabbits. They are adept swimmers because their hind feet have less fur and longer claws than other cottontails. When the marsh rabbit is not hidden in dense vegetation, it will submerge itself in muddy water, leaving only its eyes and nose exposed. It will lay its ears flat on its head in order to hide as well. This allows them to escape quickly from predators such as the marsh hawks, snakes, alligators, great horned owls, and foxes. Dogs, however, easily capture them when they try to escape on land using a doubling method. They may squeak while fleeing danger.

The marsh rabbit can breed throughout the year, and litters typically contain two through four young. Female marsh rabbits will usually produce six litters in a year, with an average number of fifteen to twenty baby rabbits. Mother rabbits will build a nest out of grasses, rushes, leaves, and hair from adult rabbits. These nests are often surrounded by water in dense vegetation and thickets.

The conservation status of the marsh rabbit is of least concern, excluding the Lower Keys marsh rabbit, and they are hunted in many places. In some areas, hunters will burn grasses in order flush out the marsh rabbit and the swamp rabbit. Some states have listed the marsh rabbit as a game animal, so hunting is controlled by the Department of Natural Resources. In South Carolina, the marsh rabbit-hunting season is November 27 through March 2, and there is a limit of five rabbits bagged per day. The marsh rabbit is called a Pontoon in Georgia. Many areas of the eastern United States will serve muskrat meat, often labeled as marsh rabbit, and serve it stewed or fried.

Dropbox Apps Removed From App Store

Michael Harper for RedOrbit.com

You don´t get to be one of the best companies in the world by being nice. When Apple announced their App Store subscription feature to iOS developers last year, they gave users the ability to subscribe to magazines and newspapers from within an app. In doing so, Apple also made any company hand over a 30% cut of each subscription made within the app. Apple also said any subscription must be made within the app, meaning a publication couldn´t take users from the app into the Safari web browser to sign up for a subscription behind Apple´s back.

It seems Dropbox forgot about this guideline when releasing their latest SDK, as developers have been having their Dropbox-friendly apps rejected by Apple this week.

A typical rejection from Apple reads this way:

“We have found your app provides access to external mechanisms for purchases or subscriptions to be used in the app, which is not in compliance with the App Store Review Guidelines. Specifically, this app contains a link that takes the user to Dropbox via Safari.”

Boasting more than 50 million users, many people use Dropbox for their cloud-based needs. Dropbox offers an entry level account with 2GB of storage for free with paid subscriptions available offering larger amounts of storage. These apps in question provided a link to Dropbox´s site to sign up for an account. This link would then take users from the initial app into Safari, thus violating Apple´s In App subscription guidelines. A developer identified as Goran Daemon P. had his iOS app rejected by the App Store for including the external Dropbox support. He wrote on Dropbox´s forums, “Once the user is in Safari, it is possible for the user to click ‘Desktop version’ and navigate to a place on Dropbox’s site where it is possible to purchase additional space,” he wrote. “Apple views this as ‘sending user to an additional purchase’ which is against rules.”

Dropbox tried removing the link to their desktop version from the SDK in attempts to appease the App Store approval process, but to no avail. Dropbox has now posted an older version of their SDK on their site as a temporary work-around. Dropbox has now said they are working with Apple to find a solution to this problem. In a statement to AppleInsider, a spokesperson for Dropbox said, “We´re working with Apple to come up with a solution that still provides an elegant user experience.”

Dropbox is a popular cloud-based service which syncs a folder on a user´s desktop with a folder in the cloud, allowing devices such as iPhone and iPad to have access to these files anywhere. When Apple first opened up the App Store, many began using Dropbox as a way to get around the iPhone´s lack of a file system.

Apple and Dropbox have had minor run-ins before. In 2009, Steve Jobs reportedly offered Dropbox founder Drew Houston a nine-figure sum to buy the startup. After Houston and his partner declined, he warned them Apple would be introducing their own cloud option. iCloud was released last June, and while it doesn´t work exactly like Dropbox, it does provide seamless syncing across multiple Apple devices.

VPNs Become File Sharing Sites

Peter Suciu for RedOrbit.com

A decade ago peer-to-peer filing sharing service Napster was essentially shut down for copyright infringement. Many in the music industry likely hoped that would be the end of digital piracy, but in fact it was only the beginning of a trend in the illegal sharing of music and movies.

Since Napster, many sites have come and gone, but now young people are increasingly turning to virtual private networks (VPNs) as a way to share files. According to a study from Sweden’s Lund University, there has been a 40 percent increase in the number of 15 to 25-year-olds using these services since 2009.

VPNs are set up as a secure network that essentially uses public telecommunication infrastructure, including Internet, to provide access to a central organizational network. Whilst VPNs require remote users of the network to be authenticated, and even offer firewalls and encryption technology to prevent the unauthorized disclosure of private information, these are now being used as a way to share files and data anonymously.

The study, which was carried out by the Cybernorms research group at Lund University, revealed that more than 700,000 Swedes use anonymous VPN services such as Pirate Bay’s iPredator. This is an increase from 2009, when 500,000 Swedes were taking steps to become anonymous with their online connections.

VPNs could be one way for those wishing to share files illegally to stay ahead of site shutdowns and avoid copyright infringement. Last year New Zealand enacted legislation that was aimed at deterring illegal file sharing, including a P2P file sharing ban. However, some sites offer advice on using VPNs to mask a user’s identity for non-lawbreaking uses.

The website Purevpn noted: “For those you who want to use P2P file sharing for legal and personal purposes (and not for any illegal activities), we recommend using VPN service to change your IP location. Choosing a secure VPN connection would enable people to share files in a more secured way. The problem is, and always will be when it comes to holding an alternate IP address, it will be even more difficult to trace down the offender who uses the internet secretly. In the end, the onus lies with the netizens to use the available internet services for legal purposes only and avoid illegal file sharing using VPN as well.”

And, according to the researchers, the number of individuals aged 15 to 25-years-old now hiding themselves online accounts for 15 percent of online users, up from 10 percent in 2009.

But it is likely that the music industry won’t back down. While it has shifted its focus away from individual file-sharers to going after the services, and working to shut down sites via domain name service blocking – which in essence stops anyone trying to get to the site – this may only be the first step. VPNs could be the next big target.

“VPNs could become the next front in the battle against piracy,” independent music analyst Mark Mulligan told BBC News.

In the corner of the music industry are governments as well. In addition to Sweden, the UK, Spain, Austria, Finland, Belgium, Denmark and Italy have declared a war on piracy and The Pirate Bay. And just as piracy on the high seas was eventually stamped out through international efforts, these efforts could bring down additional piracy as well.

Blood Test Spells Out Blood Types

Connie K. Ho for RedOrbit.com

Researchers at Monash University recently developed a paper-based device that writes blood type as text and can be used by emergency-response teams in humanitarian disasters.

The study, published in the journal Angewandte Chemie, describes how the sensors uses the ABO system, categorizing blood types as A, B, AB, or O and positive or negative. The system designates which antigens are in the blood (i.e. A blood has A antigens, B blood has B antigens, and blood type O has no antigens).

Lead researcher Professor Wei Shen of Monash University was inspired to create the device after watching the film, Harry Potter and the Chamber of Secrets. In one scene, Harry writes a question on a paper about the Chamber of Secrets and the paper responds with an answer in writing.

“The movie shows that you can have a text result, and that’s where the idea comes from,” Shen stated in an abc.net.au article.

Shen believes that the blood test can come in handy, as sometimes mistakes made during blood test interpretation can have serious consequences.

“We found that more than 80% of the population“¦ could not interpret the result even if the result from a perfectly functioned blood typing assay was presented to them,” commented Shen in an article by the BBC article. “But with a device that can spell out the patient’s blood type in written text, people will know their blood type easily.”

The team found that the paper-based blood test device they developed was comparable to the ones used in hospitals, with theirs being cheaper, faster, and easier to use.

“We have tested 99 samples and so far we have found it has the same accuracy as the mainstream blood typing tests,” Shen told abc.net.au.

With such user-friendly capabilities, the groundbreaking device could be used in developing countries as well.

“Studies show that errors are linked mostly to incorrect registration of the results to the blood sample, or human error,” Shen told BBC News. “In developing regions and remote areas, mainstream technologies are not available, and non-mainstream methods are used. Misinterpretation of assay results by less-trained health personnel is likely to be a major worry.”

The tool is made of a small, square-shaped paper-based sensor that has a layer of water-repellant coating, except for four areas on the surface that are shaped in different blood letter types. For example, one area is shaped in the letter “A,” another area shaped in the letter “B,” and another area has the “minus” sign. These areas can absorb liquid and contain antibodies to interact with blood cells, clumping based on the type of blood it is.

So, when blood type B is dropped on the paper, it will fill the part of the paper that has antibodies responding to blood type B, creating a letter “B” on the paper. The letter is readable even when the sensor has water on it. Since blood type O has no antigens, the researchers filled that area with antigens that were opposite to antigens A and antigens B. If the blood sample was not O, then the antigens would fill it and it would make an “X” mark. However, if the blood sample was blood type O, when the paper was washed with saline liquid, the researchers would be able to see that there was an X marked in white with a red letter O left, signifying that the blood sample was blood type O.

“The major novelty is in the ease of reading the strip by spelling out the letters for specific blood types,” explained Dr. John Brennan, the Canada Research Chair in Bioanalytical Chemistry, in an interview with BBC. “I think that there are places where such strips might be used, such as rapid response scenarios – battlefield casualties, automobile accidents, etc – where rapid blood transfusion is required. In such cases an unambiguous readout such as that provided by these strips would be important.”

Controversial Avian Flu Research Finally Published

Connie K. Ho for RedOrbit.com

A controversial report regarding avian flu research was finally published on May 3 in the journal Nature.

The research, which studies how the avian H5N1 influenza spreads among mammals, had been contested by a government review panel who wanted to stop the report from being published.

According to Med Page Today, the study finds four key mutations in a gene of the H5N1 avian flu that helps it adjust to mammals. The debate about the publication of the paper was based on fears that terrorist groups or criminals could use the findings to harm others.

“This information could be used by an aggressor and shows one of the building blocks for the development of a potential BW [biowarfare] weapon,” highlighted the AFP on the report´s response to the danger of publicizing the information.

Flu and public health researchers argued that the study was important in informing the public to be prepared and aware of the virus.

“Our study shows that relatively few amino acid mutations are sufficient for a virus with an avian H5 hemagglutinin to acquire the ability to transmit in mammals,” remarked Yoshihiro Kawaoka, a University of Wisconsin-Madison flu researcher, in a prepared statement. “This study has significant public health benefits and contributes to our understanding of this important pathogen. By identifying mutations that facilitate transmission among mammals, those whose job it is to monitor viruses circulating in nature can look for these mutations so measures can be taken to effectively protect human health.”

The group of researchers had already identified a subset of viruses in some poultry in Egypt and parts of Southeast Asia. Kawaoka´s study on the H5N1 virus transmissibility found that there were unknown mutations that could pass. With these unknown mutations, he believes that it is important to continue the research to find out how the mutations function. The findings also show that the viruses that currently circulating in nature only need four mutations to the hemagglutinin protein to become a bigger risk to human health. The team looked at a laboratory-modified bird flu/human flu hybrid virus that could affect humans with a few mutations. They learned that the virus could be controlled by medical countermeasures like an H15N vaccine or oseltamivir, an antiviral drug.

“H5N1 viruses remain a significant threat for humans as a potential pandemic flu strain. We have found that relatively few mutations enable this virus to transmit in mammals. These same mutations have the potential to occur in nature,” commented Kawaoka in the statement.

The H5N1 virus, since 2003, has affected at least 600 human and killed half of the people it´s infected. The virus, found mostly in Asia, can be transmitted in close proximity of fowl but it doesn´t easily transmit among humans. The flu depends on its ability to take control of host cells, make new virus particles that can then infect other cells, and transmit to other hosts. However, the flu virus must change its topography to adjust to new host species. As such, the protein hemagglutinin allows viruses to enter host cells and uses a “globular head” to bind to the host cell. The amino acids in the hemagglutinin can then unlock the host cell, allowing the virus to enter and spread the infection.

“The first clues about what properties of the HA protein, other than receptor specificity, might be important for mammalian airborne transmission,” described Vincent Racaniello, a virologist at Columbia University, in a Nature article. “It would have been a huge loss not to publish this.”

Overall, flu viruses are powerful in their ability to adapt to new animal hosts, exchange genetic information, and then mutate.

“It is hard to predict. The additional mutations may emerge as the virus continues to circulate.”

As such, the study identifies the tool that allows H5N1 to transmit and helps them better understand the basis of the how the influenza virus transmits.

“Should surveillance activities identify flu strains accumulating additional key mutations, these emerging viruses should then be priority candidates for vaccine development and antiviral evaluation,” mentioned Kawaoka in the statement.

Furthermore, it will help governments better develop their public health policies.

“That is an important public health message, we have to take H5N1 seriously. It doesn’t mean it will become a pandemic, but it can,” noted Malik Peiris, a virology professor at the University of Hong Kong who wrote an accompanying commentary, in an interview with Reuters.

Genes May Explain Why Some People Don’t Like Meat

If you don’t like the taste of pork, the reason may be that your genes cause you to smell the meat more intensely, according to a new study.
Duke University Medical Center scientists, working with colleagues in Norway, found that about 70 percent of people have two functional copies of a gene linked to an odor receptor that detects a compound in male mammals called androstenone, which is common in pork. People with one or no functional copies of the gene can tolerate the scent of androstenone much better than those with two, the researchers said.
Hiroaki Matsunami, Ph.D., a Duke associate professor of molecular genetics and microbiology, had previously discovered and described the genetics of the odor receptor for androstenone (OR7D4). But it wasn’t until a group of pork scientists in Norway contacted him that he launched an experiment to learn more precisely at a genetic level how humans perceive the smell of meat.
The Norwegian team had practical reasons for the study: It was concerned what might happen in Europe if a castration method for swine were outlawed. Currently, female pork meat and castrated male pork meat are sold in Europe. The researchers were curious how consumers might respond to meat from noncastrated males.
The level of androstenone in noncastrated pigs ranges up to 6.4 ppm. In Norway the level of androstenone in immunocastrated (using hormones) pigs is from 0.1 to 0.2 ppm, and in surgically castrated pigs the rate approaches zero.
The findings raise the possibility that more consumers will dislike meat if castration is banned and more meat from noncastrated animals is sold, Matsunami said.
The study was published May 2 online in the PLoS ONE open-access journal.
A total of 23 subjects were recruited: 13 consumers and 10 professional sensory assessors. When all of the subjects were divided into sensitive and insensitive cohorts according to a smell test that was previously devised, all of the androstenone-sensitive subjects had the RT/RT genotype, with two copies of the functional RT gene.
“I was surprised at how cleanly this experiment showed who smelled what,” Matsunami said. “The results showed that people with two copies of the functional variant of the gene for that odor receptor thought that the meat smelled worse with higher levels of androstenone added.”
For the experiment, the researchers added only biological levels of androstenone to existing pork meat, up to the limit of what might be found in male wild boars.
Matsunami said it would be fascinating to see results done on certain populations, including people in the Middle East, where pork has been omitted from diets for centuries.
“I would also like to know about odor receptor variants in indigenous populations, such as people who live near the Arctic Circle and who never eat these meats. What is their genotype?” Matsunami said. Vegetarians as a group may also have a genetic predisposition against the smell of meat, but all of these ideas need to be scientifically studied, he said.
Matsunami also speculated whether meat inspectors with both copies of the functional variant, who presumably would be more sensitive to higher levels of androstenone, might make different decisions in their jobs.
The availability of the humane genome has given us the tools for revising sensory and consumer science involving flavor perception, said co-author professor Bjørg Egelandsdal of the Institute of Chemistry, Biotechnology and Food Science at the University of Life Science, in Ã…s, Norway. “This could be very useful in product development, to learn which flavor sensors are correlated with which flavors. More research is needed, but we may be able to revise the way we recruit consumer groups for evaluating product development.”
Another practical solution for meat producers would be to find other compounds that are safe to ingest, but that might block the androstenone receptors to reduce that scent in meat.

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May Is National High Blood Pressure Awareness Month

Connie K. Ho for RedOrbit.com
May is the month to raise awareness on multiple issues. There´s Healthy Vision Month, as promoted by the National Eye Institute. Now there´s the National High Blood Pressure Education Month and Stroke Awareness Month, promoted by the U.S. Department of Health and Human Services (HHS).
According to the HHS, one in three U.S. adults has high blood pressure (otherwise known as hypertension). Hypertension is called “the silent killer” because it doesn´t have any obvious symptoms but can cause damage to the brain, heart, and kidneys. Furthermore, many Americans don´t have hypertension correctly controlled. African Americans, in particular, are more at risk for developing hypertension and having it diagnosed at a younger age.
Similar to the consequences of hypertension, strokes can lead to serious complications and it´s touted as the fourth leading cause of death in the U.S.  The HHS reports that over 795,000 Americans have a stroke each year and over 130,000 people in the U.S. die each year from having a stroke. A stroke happens when there is a blockage that keeps blood from funneling to the brain or when a blood vessel in or around the brain ruptures. According to the Center for Disease Control and Prevention (CDC), strokes can lead to a multitude of complications, including depression, difficulty controlling or expressing emotions, numbness, paralysis, problems with thinking, as well as pain in the hands and feet. The CDC also reports that demographic factors like age, ethnicity, family history, and sex can affect a person´s risk for having a stroke.
With such shocking statistics, the HHS and the CDC have teamed up for a new project called the Million Hearts Initiative that aims to prevent one million heart attacks and strokes by 2017. Million Hearts hopes to promote the importance of reducing blood pressure by working with individuals, employers, insurers, health professionals, and health systems on highlighting the connection between good blood pressure and good health. They also publicize the need for regular self-monitoring of blood pressure as well as controlling blood pressure with diet and exercise.
Apart from the Million Heart initiative, the CDC provides a few tips for people to help lower risk for having a stroke. The organization advocates maintaining a healthy diet, limiting alcohol intake, and exercising regularly. They also believe it´s important to prevent or control diabetes.
“Many people don´t know that heart attacks and strokes are preventable. Just because your father, your mother, or your brother suffered a heart attack or a stroke, doesn´t mean that you will, too. Your DNA is not your destiny,” wrote Dr. Janet Wright, executive director of the Million Hearts initiative, in a guest post on the American Association of Retired Persons (AARP) blog. “Right now–National High Blood Pressure Education Month–is the perfect time to learn more about your own blood pressure and how controlling it protects your heart.”
The CDC also addresses signs of what a stroke might feel like to people; this includes trouble seeing in one eye, having an intense headache with no known cause, as well as having trouble speaking or walking.
“On behalf of all the Million Hearts public and private partners, I encourage you to talk with your doctor, nurse, pharmacist, or community health worker about how else you can keep your blood pressure in the normal range,” concluded Wright in her post on the AARP blog.

Turn Signal Neglect A Continuing Problem In The US

Jason Farmer for RedOrbit.com

A recent in-depth study by the Society of Automotive Engineers (SAE) of turn signal rates-of-neglect has yielded some surprising and somewhat disturbing results. The study reveals just how rampant the problem is and gives an idea of the number of accidents caused, or potentially caused, each year by improper usage of turn signals. Solutions to the problem were also offered by the researchers in the study and were presented at the 2012 SAE World Congress.

The extensive study recorded the turn signal usage of 12,000 vehicles as they changed lanes or made turns. The data reveals the rate of turn signal neglect for vehicles changing lanes is 48%. Vehicles making turns improperly used turn signals 25% of the time. The statistics extrapolated to include all U.S. drivers means that turn signal neglect occurs over 2 billion times a day, or 750 billion times a year.

The data collected in the study indicates that turn signal neglect is responsible for up to 2 million accidents per year. This would mean that improper usage of turn signals causes more than twice the number of collisions than those resulting from distracted drivers, which, according to the U.S. Department of Transportation, approaches 1 million. Given the myriad variables contributing to driver distraction, no one is quite sure how to effectively deal with that problem. However, researchers in the study have concluded that recent Smart Turn Signal technology may offer a very effective solution to the problem of turn signal neglect.

Vehicles can be fitted with Smart Turn Signal technology that use sensors and computer analysis to shut off the turn signal when necessary and remind motorists to use the turn signal on a regular basis and at the appropriate time. If the computer detects a pattern of a driver´s neglect to use the turn signal properly, it will offer a prompt to do so, like the beeping sound that reminds drivers to wear their seatbelts. The technology has been shown to assist drivers in establishing good signaling habits and can greatly reduce the risk of accidents and traffic violations.

Another potential benefit of the Smart Turn Signal technology is the savings in cost to car manufactures and buyers. The Smart Turn Signal uses already existing Stability Control System sensors standard in all new cars. And, with the new technology, the standard turn signal trip mechanism can be eliminated, also reducing weight and space in the vehicle. While it has been a very effective safety feature on all cars since it was implemented in 1940, the turn signal trip mechanism has not been improved upon since.

“This is a first of its kind report on a subject that amazingly, has never been studied. The turn signal is one of the very original automotive crash prevention devices and this simple driver to driver communication device remains extremely effective, but only when it is accurately displayed as required by law”, states Richard Ponziani, P.E., President of RLP Engineering and author of the report. “The turn signal can no longer be considered ℠optional´ and all drivers have an ongoing duty to use it, just as they have a duty to stop at a stop sign or at a red light” he added. Ponziani further stated: “Smart Turn Signals are the perfect complement to the Stability Control System since Stability Control predominately prevents single-vehicle crashes, whereas the Smart Turn Signal prevents multi-vehicle crashes.”

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Will Apple Keep Austin Weird?

Image Credit: Photos.com

Michael Harper for RedOrbit.com

Last June, Steve Jobs visited the Cupertino City Council to make a pitch for their new “spaceship” campus. Pitching his plans for the new facilities, Steve Jobs told the city board members, “Apple is growing like a weed“¦

Now, in further response to such growth, Apple and Austin have agreed to terms and will begin construction on a new Texas facility this summer.

Apple first announced plans to break ground on a new $304 million campus in Austin, Texas back in March.

Now, local courts in Austin have voted and approved Apple´s move to the Lone Star State.

According to the Statesman, the Travis County Commissioners Court voted 4-1 in favor of a deal which will give the iPad maker anywhere from $5.4 to $6.4 million in tax rebates over the next 15 years.

For their part, Apple will be investing $282.5 million into the town during construction. Apple´s new campus is expected to bring nearly 3,600 new jobs into the growing tech industry of South Texas.

As a part of the deal between the two, Austin has asked Apple to verbally commit to hiring locally for their new facilities.

Many of the new jobs created by the new campus will be entry-level with expected salaries starting at $40,000. Their new campus is slated to be finished in 2021.

Plans had been stalled and “in peril” a few days ago as Travis County staffers felt part of the proposed contract would have given too much in the form of tax incentives to Apple.

Dan Houston, Austin-based economic consultant, said a few stalls shouldn´t run Apple away from the deal.

“If you´re Apple and you´re prepared to spend a couple hundred million dollars, what´s a couple more weeks of negotiating?” he said.

Apple isn´t a stranger to the live music capital of the world. They´ve had a customer support and complaints center there for years, and according to Apple, “Thousands” of people are employed in these facilities.

In explaining their move to Austin, Apple spokesman Steve Dowling told Reuters, “Our operations in Austin has grown dramatically over the past decade from less than 1,000 in 2004 to more than 3,500 today.”

The new campus will be called the Americas Operation Center and will serve as “the hub for the company in the Americas.”

Apple will begin construction on the new facility next month next to their existing customer service facilities in Riata Vista in North Austin.

Governor Rick Perry stated his approval in a March statement, saying: “Apple is known for its bold innovation and game-changing designs, and the expansion of their Austin facility adds to the growing list of visionary high-tech companies that have found that Texas´ economic climate is a perfect fit for their future, thanks to our low taxes, reasonable and predictable regulations, fair legal system and skilled workforce.”

“Investments like this further Texas´ potential to become the nation´s next high-tech hub.”