FBI Seizes Server Allegedly Linked To University Bomb Threat

The FBI has seized a server used by an anonymous remailing service provider and several progressive service organizations as part of an ongoing investigation into anonymous bomb threats at the University of Pittsburgh — a move which has reportedly drawn criticism from digital anonymity advocates.

The server was seized Wednesday from a co-location facility located in New York after FBI officials presented a warrant, Wired‘s Kim Zetter wrote on Friday. The server was used by Mixmaster, a remailing service which Zetter says “helps human rights activists and others prevent their communications from being traced to them,” as well as Riseup Networks and May First/People Link.

The move was made “in an effort to uncover the source” of the bomb threats, according to Wired, and the seizure affected more than 300 email accounts, as many has 80 email lists, and multiple websites, none of which have been linked in any way to the University of Pittsburgh bomb threats, Riseup said in a Thursday press release.

“The server seizure is not only an attack against us, but an attack against all users of the Internet who depend on anonymous communication,” May First/People Link director Jamie McClelland said in a statement.

“The FBI is using a sledgehammer approach, shutting down service to hundreds of users due to the actions of one anonymous person,” added Riseup spokesman Devin Theriot-Orr. “This is particularly misguided because there is unlikely to be any information on the server regarding the source of the threatening emails“¦ We sympathize with the University of Pittsburgh community who have had to deal with this frightening disruption for weeks. We oppose such threatening actions. However, taking this server won´t stop these bomb threats.”

In addition, Forbes Staff Writer Andy Greenberg said that the FBI has allegedly seized the computers of a couple who are also being questioned as part of the investigation.

Greenberg also says that McClelland has denied previous Pittsburgh Post-Gazette reports that the server seized Wednesday, which was operated by Italian ISP European Counter Network (ECN), had been “hijacked” by the user who sent the anonymous bomb threats.

Both Greenberg and Jeremy Kirk of IDG News Service attempted to contact FBI officials for comment, but neither had received a response as of their respective press times.

Regarding the investigation into the bomb threats, earlier this month David J. Hickton, United States Attorney for the Western District of Pennsylvania, released a statement saying that, “The safety and welfare of the University of Pittsburgh community is a top priority” and that the incidents, which started on February 13, were “being vigorously, aggressively and thoroughly investigated through every possible means.”

“The Joint Terrorism Task Force, which includes the University of Pittsburgh Police as a productive, contributing member, is actively pursuing the source or sources of these threats,” Hickton said. “While the disruption and fear engendered by such threats is unconscionable, we commend the resilience of the University community. The University of Pittsburgh is exercising appropriate regard for safety, through its notification system and through evacuations when threats are received and evaluated, while refusing to allow such threats to paralyze the entire University community in its pursuit of learning and teaching.”

Robots Could Be The Future Of Prostitution

Lee Rannals for RedOrbit.com

Researchers believe that one day prostitutes might lose their grip on the underground sex realm to robots.

The slutty robots would become the apple of the eye for those wanting to partake in the sex-for-profit industry in 2050, according to Australian researchers Ian Yeoman, management professor, and Michelle Mars, sexologist.

They wrote in a journal called Futures that they envision an Amsterdam sex club called “Yub-Yum” that is littered with robot women, who will be “sexual gods and goddesses of different ethnicities, body shapes, ages, languages and sexual features.”

“It is modern and gleaming with about 100 scantily clad blonde and brunettes parading around in exotic G-strings and lingerie,” the researchers wrote. “Entry costs $10,000 for an all inclusive service.”

They predict that an increase in human trafficking in the sex industry during the 2040s will help drive this future industry, as well as an increase in incurable sexually transmitted infections.

Yeoman and Mars also predict the future club will be voted the world’s best massage parlor by the U.N. World Tourism Organization.

But, the acclimation for the future club does not just revolve around sex.  The researchers envision that the club will receive awards for its technology and innovation in robotics, including “the prestigious ISO iRobotSEX award.”

“The most popular model is Irina, a tall, blonde, Russian exotic species who is popular with Middle Eastern businessmen,” the researchers wrote in their vision about the sex industry future.

They said the androids will be made of bacteria resistant fiber and flushed for human fluids, guaranteeing no sexual transmitted diseases are transferred between the slutty machinery and its human lover.

They also believe that human prostitutes will be complaining that they are unable to compete on both price and quality, forcing many to quit the business altogether.

“All in all, the regeneration of Amsterdam’s sex industry has been about the success of the new breed of sex worker,” the researchers conclude. “Even clients feel guilt free as they actually haven’t had sex with a real person and therefore don’t have to lie to their partner.”

Yeoman and Mars said they came up with their predictions based on the growth of the sex industry, the human fascination with physical beauty, and the predicted social reforms to combat human trafficking.

They hypothesize that another reason for popularity in this industry in the future is that people would be more open and honest about paying for sex with robots than paying for sex with humans.  Also, more spouses may be open to the idea of their significant others going after a sexbot, rather than a real human hooker, according to the researchers.

The two researchers said they centered their paper on the Amsterdam sex trade because of the city’s long history as a sex tourism destination.

Apple, Google, Etc To Answer For Anti-poaching Agreements

Michael Harper for RedOrbit.com

Apple and Google are no strangers to court. This time, they, along with 4 other tech companies, will be heading to court to face an antitrust lawsuit over claims they conspired not to “poach” one anthers employees.

The companies had asked the court to dismiss the case, but District Judge Lucy Koh in San Jose, California rejected their request. According to Judge Koh, the companies “Do Not Call” agreements among the defendants “supports the plausible inference that the agreements were negotiated, reached, and policed at the highest levels” within the companies.

Judge Koh then went on to suggest the manner in which these companies reached these internal agreements suggested possible foul play.

“The fact that all six identical bilateral agreements were reached in secrecy among seven defendants in a span of two years suggests that these agreements resulted from collusion, and not from coincidence,” Koh added, according to Reuters.

“For example, it strains credulity that Apple and Adobe reached an agreement in May 2005 that was identical to the “Do Not Cold Call” agreement Pixar entered into with Lucasfilm in January 2005,” Judge Koh added.

Joining Apple and Google in the lawsuit are Adobe Systems Inc., Intuit Inc., Lucasfilm Ltd. and Pixar.

The class action suit against these companies was brought by 5 software engineers who claim the companies conspired with one another to lower employee pay. The software engineers claim their employers conspired not to hire from one another, thus stalling the skilled labor market.

Similar claims have already been brought to court, as a 2010 investigation by the Department of Justice ended with the companies saying they would not take action to restrict competition, such as setting limits on cold-calling and recruiting.

During this investigation, the companies were able to reach this conclusion without admitting any wrong doing, however.

Judge Koh believes such significant and company-wide policies must have come from the top of the organizations, and as such suggests there could have been some foul play.

The late Apple CEO Steve Jobs is being mentioned in the case as well, as one of the plaintiffs refers to an email exchange between Jobs and Schmidt, CEO of Google and, at the time of the email, a board member of Apple. This email could be damning, as it shows both CEOs cooperating to stop the transfer of an employee from one company to another.

According to Reuters reporter Jonathan Stempel, a Google recruiter had tried to poach an Apple employee. When Jobs found out about this, he sent a “polite” email to Schmidt, saying, “I would be very pleased if your recruiting department would stop doing this.”

Surprisingly, Schmidt consented, and sent an email down his chain of command in order to stop the transfer.

“Can you get this stopped and let me know why this is happening?” Schmidt wrote to undisclosed recipients as he forwarded his message from Jobs.

According to CNET, In 2009 Apple and Google were said to have had an “unofficial agreement” not to hire one another employees. Despite being unofficial, the effect was being felt by software engineers.

The case remains on case for a June 2013 trial.

Exercise Helps Smokers To Quit Smoking, To Remain Smoke-Free And To Reduce The Risk Of Death

New study presented at the World Congress of Cardiology organized by the World Heart Federation

Exercise may help smokers to quit and remain smoke free, according to new data presented today at the World Congress of Cardiology. Moreover, exercise increases life expectancy in smokers and non-smokers alike.

The study of 434,190 people who went through medical examination program at a private fee-paying company between 1996 and 2008 in Taiwan revealed that active smokers (those engaged in at least moderate activity) were 55 per cent more likely to quit smoking that those that were inactive. Furthermore, these active smokers were 43 per cent less likely to relapse than smokers that were inactive.

Physical activity among these subjects was also shown to increase life expectancy, even among smokers. Smokers that participated in physical activity had an increased life expectancy of 3.7 years and a reduction in all-cause mortality of 23 per cent — equivalent to levels achieved by ex-smokers with low activity levels. The results also demonstrated that active ex-smokers increased their life expectancy by 5.6 years and reduced their all-cause mortality by 43 per cent — equivalent to the levels seen in inactive non-smokers.

“Exercise can help smokers to quit and quitting smoking has been shown to significantly reduce the risk of developing CVD and that must be the goal of all smokers,” said Dr. C.P. Wen, National Health Research Institute, Taiwan. “If smokers can continue to exercise, not only they can increase the quit rate, but also they can reduce their mortality for all cause and for CVD in the long run.”

The prospective study of 434,190 individuals in Taiwan was conducted over a period of 12 years. Leisure time physical activity of each individual was grouped into 1) Inactive, 2) Low active (15 minute/day), and 3) Active (30 minute/day).

Tobacco use and cardiovascular disease

Smoking is one of the major causes of CVD and directly responsible for one-tenth of all CVD worldwide. Smokers are almost twice as likely to have a heart attack as people who have never smoked. Moreover, second-hand smoke exposure is responsible for 600,000 deaths every year.

A person can substantially lower their CVD risk by stopping smoking. Within five years of becoming a non-smoker, a person’s risk of having heart attack is halved and within 15 years the risk of developing CVD becomes nearly the same of someone who has never smoked.

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Dogs And Their Owners Have Matching Personalities

Lawrence LeBlond for RedOrbit.com

It is often said that dog owners display an uncanny resemblance to their pets, but a new study goes one step further and suggests that their personalities are similar as well.

In a study of British dog owners, researchers revealed that people tend to choose animals that match their own personality. They suggest that people are subconsciously drawn towards different types of dogs based on their characteristic personalities.

Based on results of the research, such people as the Queen of England, Paris Hilton, and even Sir Isaac Newton, may have all owned dogs that resembled their own personalities.

“We go for dogs that are a bit like us, just as we go for a romantic partner who is a bit like us,” study researcher Lance Workman, a psychologist at Bath Spa University in the United Kingdom, told LiveScience.

Workman and colleagues, interested in how personality traits influence real-world behavior, focused their attention on dog ownership because previous studies have found personality differences between dog owners and non-dog owners.

In one study, the researchers found that people are even able to match purebred dogs with their owners, suggesting that certain breeds of dogs are associated with certain types of people.

Take the Duke and Duchess of Cambridge for example. Their choice of a cocker spaniel, Lupo, suggests intelligence, agreeableness and conscientiousness. And Corgi owners, such as the Queen of England, tend to be extroverted.

The study authors found that agreeable types of people are drawn to Labradors, which are known for their friendliness, while hard-working a responsible people are drawn to bulldogs, which have no-nonsense personalities. And those who have active lifestyles, spending lots of time outdoors, may be attracted to retrievers and greyhounds, they added.

For the study, Workman and colleagues surveyed 1,000 dog owners via an online questionnaire on behalf of the British Kennel Club. The questions tested the so-called “Big Five” traits that govern our personality: extroversion, agreeableness, emotional stability, conscientiousness and intelligence.

To simplify the process, the authors split the dog breeds into seven Kennel Club categories: gun dogs, such as the Lab or golden retriever; hound dogs, such as the greyhound; pastoral breeds, including German shepherds and collies; terriers, such as the Staffordshire bull terrier; toy breeds, including Chihuahuas; utility breeds, such as bulldogs; and working breeds, such as the Doberman.

They found the most extroverted people owned pastoral or utility breeds, while those who were most agreeable owned toy dogs or gun dogs. The most emotionally stable people tended to own hounds. The authors found that toy dog owners were also the most imaginative people. Those who scored higher than average on intelligence usually own working dogs.

One of the most surprising finds, said Workman, was the association between people and toy dogs, which threw the stereotypes of those people right out the window.

“One of the great things was that toy dog owners, who are often seen as airheads, came out pretty much on top when it came to openness, creativity and intelligence,” he told LiveScience. As an example, he noted that “Isaac Newton had what we´d today call a toy dog, a Pomeranian. He could take it around with him. It was easy to handle and left his mind free for other things.”

He said that some people may be surprised to find that owning a cairn terrier makes Simon Cowell agreeable. “TV personalities often play a role,” added Workman. “I don´t know Simon Cowell but it may be that if you know him personally that he is a nice chap to have around.”

Workman said there was a definite link between a dog´s temperament and their owner´s personality. “I think when you look for a dog at some level, largely subconsciously, you look for something that is a bit like you,” he explained. “It´s a bit like a romantic partner. If they fit in they will probably last, and contrary to popular opinion with romantic partners opposites don´t attract – you need to have a lot in common if it´s going to last.”

He noted that someone´s choice of dog could also reveal hidden personality traits that do not immediately come across from watching them or listening to them speak. The Queen´s fondness for corgis, for example, may signal that she is more extrovert than she appears to be.

“It takes a lot to get up and stand up in front of the number of people she does as often as she does, and give a good talk, and at the same time she has to be controlled as the head of state,” he said. “Whereas the minor royals can party she´s never been able to do that, so I think the personality that we see appears less extrovert than she actually is.”

Workman said the information from the study may also be helpful for people who are just starting to pick out a new pet. The questionnaire could be developed to include not only personality concerns, but also practical ones such as living space. This could result in a new database that offers new ways to choose appropriate breeds — which could lead to fewer dogs ending up in shelters because of owners who pick the wrong breed, he added.

Results of Workman´s study, which have yet to be peer-reviewed, were presented this week at the British Psychological Society´s annual conference in London.

Cure For Baldness? Scientists Grow Hair Follicles On Mice

Its more than a sign of aging, it can also be annoying and embarrassing. Going bald affects both men and women as they grow older. In fact, the American Hair Loss Association says two-thirds of American men will experience “notable” hair loss by age 35. This number increases to an overwhelming majority of 85% once men hit 50. Women aren´t safe either, making up 40% of the entire balding population. Now, as scientists try to reverse or completely rectify the situation, a team in Tokyo, Japan has made a new advancement.

A new study shows bioengineered hair follicles can become actual hair when transplanted into normally hairless mice. Such an advancement could lead to not only better hair transplants, but also fewer cases of baldness.

The engineered hair follicles were patched into the skin and, once there, managed to connect to surrounding tissue in order to grow hair in an organized way. Current hair transplant methods simply move follicles from one area of the body to the other. This new approach encourages new hair follicles to grow from existing cells. More than just covering up an unsightly bald spot, study coauthor Takashi Tsuji of Tokyo University of Science in Chiba, Japan says the new study also marks an advancement in organ regeneration, such as salivary glands which form in much the same way as hair follicles.

Tsuji and his colleagues detail their findings in the April 17th issue of Nature Communications.

Hair follicles are formed when epithelial cells and mesenchymal cells interact and respond with one another. As they work in tandem, the epithelial cells grow and regenerate very quickly while the mesenchymal cells tell the epithelials to make a follicle.

Tsuji and his team have engineered follicles and hair shafts from mouse embryos before. This new study marks the first time these follicles were able to organize into clusters and grow normal hair when inserted into a mouse´s skin.

The Japanese team used acetylcholine, a drug used to cause muscles to contract, to inject a region of skin with the bioengineered follicles. As they did this, the hairs began to perk up, suggesting the transplanted follicles had integrated with surrounding muscles and nerves, just like regular hair follicles.

To ensure the hairs grew in the right direction and to avoid ingrown hairs, the team used nylon string to encourage the hairs to grow up and out.

“You have to make hair that is positioned right,” Cheng-Ming Chuong, a stem cell and regeneration researcher at the University of Southern California in Los Angeles, told Rebecca Cheung of Science News Magazine.

Chuong notes one of the ways the study succeeded was in getting the follicles to grow in an organized manner, unlike prior studies, which were unable to do so. When these follicles grow without organization, cysts can form, making them of little use in clinical tests.

Tsuji and his team were also able to create functional follicles from regular adult mice. In growing the two types of hair together, the team engineered follicles capable of growing finer, whisker type hair.

Now, the team looks to human cells. By using similar methods, the team will gather cells from men with male pattern baldness and create individual follicles like the ones that grew on the mice.

Jellyfish Populations Rising With Ocean Warming, Pollution Increases

Researchers from University of British Columbia (UBC) are reporting an increase in the number of jellyfish populations in coastal areas of the world´s oceans. Many species are considered a nuisance when they sting swimmers. A larger concern is the damage they do to marine engines and power plants by clogging intakes. They are also a nuisance to fishermen

UBC scientists examined data for numerous species of jellyfish for 45 of the world´s 66 Large Marine Ecosystems. The researchers found increasing jellyfish populations in 62 percent of the regions analyzed, including East Asia, the Black Sea, the Mediterranean, the Northeast US Shelf, Hawaii, and Antarctica.

Lucas Brotz, a PhD student with the Sea Around Us Project at UBC and lead author of the study says, “There has been anecdotal evidence that jellyfish were on the rise in recent decades, but there hasn´t been a global study that gathered together all the existing data until now.”

“Our study confirms these observations scientifically after analysis of available information from 1950 to the present for more than 138 different jellyfish populations around the world.”

Daniel Pauly, the principal investigator of the project, said the expansion of human activity into marine habitats may be responsible for increasing jelly-fish populations. “We can also see that the places where we see rising numbers of jellyfish are often areas heavily impacted by humans through pollution, overfishing and warming waters.”

“By combining published scientific data with other unpublished data and observations, we could make this study truly global — and offer the best available scientific estimate of a phenomenon that has been widely discussed.”

Pauly adds that increasing anecdotal reports of jellyfish abundance may have resulted from an expansion of human activities in marine habitats, so the study also provides a concrete baseline for future studies, reports Gerry Bellett for the Vancouver Sun.

Also noted was a decrease in jellyfish abundance in seven percent of coastal regions, while the remainder of the marine ecosystems showed no obvious trend.

The study is published in this month´s edition of the journal Hydrobiologia.

New Research Discovers Cause Of Kidney Stones

Connie K. Ho for RedOrbit.com

A sharp irritation near the stomach. The feeling of pain in the back. The discovery of blood in the urine. These are just a few of the symptoms of kidney stones. An estimated one million people suffer from kidney stones each year. Recently, more information was revealed regarding the cause of kidney stones through research done by scientists at the Washington University School of Medicine in St. Louis, Missouri.

The research, unveiled in the EMBO Journal by the European Molecular Biology Organization, provides reasons as to why some people are more susceptible to kidney stones than others are. The findings allow for the development of effective treatments and tests that could assess a person´s risk of having the illness. Mice were utilized in the study and can possibly be used in clinical trials of new treatments for kidney stones.

“Now, we finally have a more complete picture detailing why some people develop kidney stones and others do not,” remarked senior author Jianghui Hou, PhD, assistant professor of medicine, in a prepared statement. “With this information, we can begin to think about better treatments and ways to determine a person’s risk of the condition, which typically increases with age.”

Generally, kidney stores form when urine becomes too concentrated and causes minerals like calcium to bond together. Diet factors, like eating foods that are high in salt or not drinking enough water, can increase the chance of having kidney stones.

Apart from dietary concerns, scientists point to genes as having a role in the formation of kidney stones. Claudin-14, a genetic variation, has been linked to kidney stones and those who have the mutation have a 65 percent greater chance of having stones. The new study has shown how variations in gene activity can influence kidney stone formation. When claudin-14 is not active, the kidney works normally and important minerals, such as calcium and magnesium, can pass through easily. These minerals are then reabsorbed into the blood where they assist in basic body functions. However, when people eat too many salty foods or do not drink enough water, the claudin-14 starts working. It prevents calcium from entering “tight junctions” in cells that line the kidneys and cannot effectively separate blood from the urine. Excess calcium then filters into the urine, which leads to kidney stones in the bladder or kidney.

Based on his research, Hou believes that treatments could be developed focused on the activity of caludin-14. He is also optimistic that tests could be created to analyze the level of claudin-14 and determine the possibility of stones. These tests could patients identify the need to change certain parts of their diet.

“Many genes likely play a role in the formation of kidney stones,” commented Hou in the statement. “But this study gives us a better idea of the way one of the major players work. Now that we understand the physiology of the condition, we can start to think about better treatments or even ways to prevent stones from developing in the first place.”

Possible Antidote For Cocaine Overdose Emerges

Connie K. Ho for RedOrbit.com
Found in more than 400,000 emergency room visits and related to 5,000 overdose deaths a year in the United States, cocaine is a highly dangerous drug that can lead to death. Scientists at the Scripps Institute of Research decided to tackle this issue head on with a study that examines a solution that can be injected to reverse the effects of cocaine overdose in emergency situations. With the solution´s success in trials with mice, the researchers hope to complete more tests to show the possible therapeutic potential of a human antibody against cocaine.
The report, published in the American Chemical Society´s journal Molecular Pharmaceutics, is a collaboration between Kim Janda, a professor in the Department of Immunology and Microbial Science as well as director of the Worm Institute for Research and Medicine, and Jennifer B. Treweek, PhD, a research associate in Janda’s laboratory. The team has worked on developing vaccines against cocaine, heroin, nicotine, and even the “date-rape” drug Rohypnol. Many of the vaccines have been “active” vaccines, which are useful against addiction and relapse but not in overdose emergencies.
With cocaine overdoses, possible consequences include hyperthermia, irregular heartbeats, seizures, and death. To address these issues, a possibility for the cocaine antidote would be an “active” vaccine that would be a ready-made solution of antibodies, similar to vaccines used to treat snakebites. The “active” vaccine would find antibodies that could bind to circulating cocaine molecules and prevent the drug from reaching the brain.
In 2005, a study by Janda and other colleagues found that injections of a mouse-derived anti-cocaine antibody, GNC92H2, could keep mice alive despite cocaine in the body. The study completed by Janda and Treweek used a genetically engineered mouse to create fully human antibodies against cocaine molecules, known as GNCgzk. These antibodies could bind ten-times more effectively than GNC92H2. Furthermore, the report by Janda and Treweek discussed developing a “passive” vaccine that would be made up of pre-formed human antibodies against cocaine that would be 10 times more powerful in binding cocaine molecules. This vaccine could be used to reverse cocaine toxicity and become a life-saving therapy for overdose victims.
“This would be the first specific antidote for cocaine toxicity,” said Janda, PhD, senior author of the report and a leader in the field of vaccines against drugs of abuse. “It’s a human antibody so it should be relatively safe, it has a superior affinity for cocaine, and we examined it in a cocaine overdose model that mirrors a real-life scenario.”
With the success of the second study, Janda and Treweek are looking into economically-friendly ways to produce F(ab’)2-gzk, a simpler version of GNCgz, in large amounts. The new treatment could help reduce the immediate effects of overdose and prevent patients´ drug relapse. They hope that the drug could later be utilized in recovery or detox programs, given to supplement other medications, and generally aid drug addicts the recovery period.
“A lot of people that overdose end up going back to the drug rather quickly,” explained Janda in a statement. “But this antibody would stay in their circulation for a few weeks at least, and during that time the drug wouldn’t have an effect on them.”

New Study Relates Selective Hearing With Brain Function

Connie K. Ho for RedOrbit.com
Imagine this: you´re in a noisy room and you spot an old acquaintance.  You go up to speak to him and you can distinctly hear what he´s saying. While his words succinctly come out clearly, you blur out the rest of the room and don´t focus on the outside noise. This selective hearing, deemed the “cocktail party effect,” has made headway with a study by two scientists from the University of California, San Francisco (UCSF).
The research, published in the journal Nature, dissects the “cocktail party effect,” which is the ability to focus on a single speaker in any environment. It is a report by UCSF neurosurgeon Edward F. Chang, MD, a faculty member in the UCSF Department of Neurological Surgery and the Keck Center for Integrative Neuroscience, and UCSF postdoctoral fellow Nima Mesgarani, PhD, who worked with three patients who were undergoing brain surgery for severe epilepsy.
With the help of the UCSF epilepsy team, the surgery was able to identify the parts of the brain that disable seizures. In the experiment, a thin sheet of 256 electrodes were placed under the patients´ skulls to record activity in the temporal lobe, where the auditory cortex sits. Chang believes that, through the recording of the brain, he and Mesgarani were able to find out more about how the brain functions.
“The combination of high-resolution brain recordings and powerful decoding algorithms opens a window into the subjective experience of the mind that we’ve never seen before,” Chang commented in a prepared statement.
In the study, patients listened to two different speeches that contained different phrases by a variety of speakers. They were asked to focus on just one speaker. Following the experiment, the subjects told the researchers the phrases that they heard and remembered. To analyze the results, Chang and Mesgarani applied decoding methods to “reconstruct” what the patients had heard based on brain activity. Their decoding method demonstrated which speaker and which phrases the subject had picked up based on neural patterns. It also determined when a listener´s attention was straying to another speaker.
“The algorithm worked so well that we could predict not only the correct responses, but also even when they paid attention to the wrong word,” Chang noted in the statement.
Others in the science community believe that the algorithm Chang and Mesgarani utilized is ground breaking.
“I’ve never seen anything like this before,” says Martin Vestergaard, a neuroscientist at Cambridge University, in an article by New Scientist.
With the results of the experiment, there is progress being made in research regarding brain processing and the human language. The findings could be utilized in studies focused on those who have language learning disorders, autism, or an impairment related to aging.
“People with these disorders have problems with the ability to focus on a certain aspect of the environment,” Chang remarked in an interview with ABC News.  “They can´t always hear things correctly.”
Companies who work in voice recognition software also find these results of interest; the engineering required to separate a single voice from a group of voices has been difficult for tech and medical developers.
“It´s something that humans are remarkably good at, but it turns out that machine emulation of this human ability is extremely difficult,” commented Mesgarani in a prepared statement.

Daily Exercise Lowers Risk Of Alzheimer’s

Connie K. Ho for RedOrbit.com
A new study by the neurological researchers of Rush University Medical Center has found that daily activity can reduce the onset of Alzheimer´s disease and cognitive decline.
The report, published in the online issue of the medical journal of the American Academy of Neurology, describes how activities done on a day-to-day basis can reduce the risk of Alzheimer´s.
“These results provide support for efforts to encourage all types of physical activity even in very old adults who might not be able to participate in formal exercise, but can still benefit from a more active lifestyle,” noted Dr. Aron S. Buchman, lead author of the study and associate professor of neurological sciences at Rush, in a prepared statement.
716 older individuals without dementia participated in the experiment by wearing an actigraph that could measure daily exercise and non-exercise physical activity. They wore the device on their wrist for ten days and, every 15 seconds, the actigraph would record an activity on a chip; if a patient didn´t move at all, it would record a zero. Apart from the actigraph, participants also underwent cognitive tests to determine memory and thinking abilities as well as self-reported any social or physical activities.
“This is the first study to use an objective measurement of physical activity in addition to self-reporting,” explained Buchman in the statement. “This is important because people may not be able to remember the details correctly.”
After an average of three and a half years of follow up, 71 patients developed Alzheimer´s disease and the research showed that people who were in the bottom 10 percent of physical activity were three times more likely to develop Alzheimer´s as compared to those in the top 10 percent who participated in intense physical activity.
“Our study shows that physical activity, which is an easily modifiable risk factor, is associated with cognitive decline and Alzheimer’s disease. This has important public health consequences,” concluded Buchman in the statement.
Health professionals believe that the study can spread an important public health message.
“We’ve known that muscle activity generates neurons in the brain, but this study gives us additional motivation,” noted physician Gary Kennedy, a director of geriatric psychiatry at Montefiore Medical Center in New York who has no affiliation to the study, in a USA Today article. “It shows you don’t have to go to the gym. Older people very often don’t want to do that.”
People of all ages should incorporate exercise in their daily activities, with tasks like cooking, cleaning, or washing the dishes, that can cut the risk of developing Alzheimer´s.
“These are low-cost, easily accessible and side-effect free activities people can do at any age, including very old age, to possibly prevent Alzheimer’s disease,” remarked Michal Schnaider-Beeri, PhD, of Mount Sinai School of Medicine in New York, in an accompanying editorial.
Lastly, with this particular study, it is important to take into account that there will be 80 million Americans who are 65-years-old or older by 2030.
“This is an important message for society as the largest growing segment of our population is old people,” remarked Buchman in an interview with USA Today. “We need to be encouraging physical activities even in very old individuals, even if their health doesn’t allow them to take part in fitness programs.”

A Stream Is A Stream Is A Stream: Or Is It?

Scientists ford high-mountain waterways in North, South America to find out

Scientists supported by NSF SEES use everything from microscopes to deep-sea submersibles in their research.

But how many SEES scientists need a machete?

During Earth Week–or any time of year–that’s exactly what LeRoy Poff requires. Poff is an aquatic ecologist and evolutionary biologist at Colorado State University and an NSF Science, Engineering and Education for Sustainability- (SEES) Dimensions of Biodiversity principal investigator.

To characterize the lesser-known aspects of the diversity of life on Earth, NSF’s decade-long Dimensions of Biodiversity campaign aims to transform, by 2020, how scientists describe and understand the scope and role of life on Earth.

The effort is funded by NSF’s Directorate for Biological Sciences, Directorate for Geosciences and Office of Polar Programs.

“By establishing networks of interdisciplinary, globally-engaged scientists, Dimensions of Biodiversity will have a lasting effect on biodiversity science,” says John Wingfield, NSF assistant director for Biological Sciences. “It has the potential to transform the way we conduct biological research in this arena.”

The Dimensions of Biodiversity campaign is important, says Wingfield, because assessing the living diversity of Earth is not as straightforward as simply listing species.

Earth is rapidly losing species. It’s happening faster than scientists can understand the roles these species play and how they function.

With their disappearance comes lost opportunities to comprehend the history of life, to better predict the future of the living world and to make beneficial discoveries in the areas of food, fiber, fuel, pharmaceuticals and bio-inspired innovation.

Poff and colleagues from Colorado State, Cornell University and the University of Nebraska are trying to change that.

They’re studying how temperature variation and extreme weather such as floods and droughts affect life in temperate Colorado and tropical Ecuadorian streams.

The scientists are comparing how aquatic insects and fish in small streams along the Colorado Front Range–which has a seasonally variable climate–and insects, fish and amphibians in streams in Ecuador, with its more stable climate, are faring at a time when Earth is heating up.

“To get to our Colorado research sites,” says Poff, “there’s relatively easy access along mostly paved roads.” But to reach streams in the cloud forest headwaters of the Amazon, he says, it takes a machete to bushwhack through tangled vines choking narrow waterways.

Poff and colleagues will identify new species in both locales by barcoding these species’ DNA, as well as track species movements based on their tolerance of warming water and declining oxygen levels.

“We’re trying to understand how animals will respond to climate change based on their evolutionary history in a particular climate zone,” says Poff.

“To do that, we need to know their physiological responses to thermal and oxygen stress. This is one of the first studies to look at the sensitivity of species to both temperature and environmental variation such as floods and droughts.”

The research team’s hypothesis is that temperate species are likely to be less sensitive to climate change than those in the tropics.

Temperate streams are subject to large seasonal differences in temperature; the organisms that live in them occupy a wide range of elevations.

In the Colorado Rockies, for example, there’s a big change between summer and winter temperatures in streams. That suggests, Poff believes, that species there could be somewhat tolerant of future climate warming.

In contrast, studying species diversity in the tropics, he says, is like taking apart the layers of a cake.

“Temperature doesn’t vary seasonally at any given altitude,” says Poff. “But as you move up in elevation you pass through layers of increasingly colder temperatures.”

He’s trying to discover whether aquatic insects, fish and frogs are restricted to a narrow range of elevation and temperature–one layer of the cake.

“If they are–and that’s coupled with a poor ability to disperse over land to find another small stream as temperatures warm–they could be more vulnerable to changes in climate,” Poff says.

He plans to use a new understanding of species’ sensitivity to climate change, and the ability of species to move with changing conditions, as a basis for developing maps for policy-makers and others.

The maps will show where animals are most vulnerable to climate change in tropical and temperate streams.

“The knowledge being developed,” says Tim Killeen, NSF assistant director for Geosciences, “will lead to improved, science-based decision-making about our common future.”

To reach that goal, Poff is fording chutes from North to South America. His research takes not only microscopes and high-tech genetics labs.

It takes a machete.

Image Caption: A project site in Colorado: a creek above Lake Isabella in the Indian Peaks Wilderness. Credit: Chris Funk

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Study Analyzes Risk Of Death With Drug Use

Connie K. Ho for RedOrbit.com

A recent study at the Centre for Addiction and Mental Health (CAMH) in Toronto, Canada found that those who are addicted to opioids have a higher risk of death than those who are addicted to alcohol and other drugs. Opioid, a psychoactive chemical, increases a person´s risk of death by 5.71 percent. The next highest disorders include addicts of methamphetamine (4.67 percent), cannabis (3.85 percent), alcohol (3.83 percent), and cocaine (2.96 percent).

The study, released in the journal Drug and Alcohol Dependence, is the largest research project that compares mortality rates among different drug users along with the longest follow-up. More than 800,000 individuals participated in the study between 1990 and 2005; during this time, more than 188,000 patients in this group died.

“One reason for undertaking this study was to examine whether methamphetamine posed a particular threat to drug users, as it has been called ‘America’s most dangerous drug,'” commented CAMH Scientist and lead researcher Dr. Russell Callaghan in a prepared statement. “The risk is high, but opioids are associated with a higher risk. We also wanted to compare mortality risks among several major drugs of abuse, as this comparison hasn’t been done on this scale before.”

His research showed a number of shocking results. 166,482 deaths and 582,771 hospitalizations were related to alcohol dependence. 4,122 deaths out of 74,139 hospitalizations were the result of methamphetamine use. 12,196 deaths out of 67,104 hospitalizations resulted from opioids.

Since specific causes of mortality were not originally found, researchers are returning to explore mortality causes for each drug group.

“These are not occasional, recreational drug users, but people who have been hospitalized for drug dependence,” remarked co-author Dr. Stephen Kish, Senior Scientist at CAMH, in the statement.

To calculate the mortality rate in each drug group, the researchers looked at the hospital records of all California inpatients that were diagnosed with methamphetamine, alcohol, opioid, cannabis or cocaine-related disorders from 1990 to 2005. They then utilized the California Vitals Statistics Database to match death records with inpatient records. Ultimately, the study shows the importance of intervention for those who are hospitalized for drug use.

New Brain Cancer Vaccine Displays Success In Second Clinical Trial

Connie K. Ho for RedOrbit.com

On Tuesday, April 17, researchers from the University of California, San Francisco (UCSF) presented results at the American Association of Neurological Surgeons (AANS) meeting in Miami, Florida that a new brain cancer vaccine tailored to individual subjects had been successful in its second clinical trial.

The vaccine is for patients who suffer from recurrent glioblastoma multiforme, a type of cancer, and it has helped extend patients´ lives. The trial compared the new vaccine with a standard treatment that lasted 47 weeks. The patients were gathered from a number of facilities, including UCSF’s Helen Diller Family Comprehensive Cancer Center, the Seidman Cancer Center at University Hospitals Case Medical Center, and at New York-Presbyterian Hospital/Columbia University Medical Center, and several of them who received the new treatment were able to survive for over a year.

“These results are provocative,” remarked UCSF neurosurgeon and lead researcher Andrew Parsa, MD, PhD, in a prepared statement. “They suggest that doctors may be able to extend survival even longer by combining the vaccine with other drugs that enhance this immune response.”

Past glioblastoma treatment has focused on surgical resection, where surgeons remove cancerous tissues from the brain and then follow up with radiation therapy and chemotherapy. Therapeutic cancer vaccines are fairly new and a prostate cancer vaccine was first approved by the U.S. Food and Drug Administration (FDA) in 2010. With cancer vaccines, patients are given an injection that induces an immune response to help the body fight pathogens. In the past, cancer vaccines were thought to not be effective. However, several brain cancer advocacy groups pooled together resources to request doctors at leading cancer institutes to look into new ways of treating glioblastoma. It lead to Parsa and his team basing the cancer vaccine on molecular bundles called heat shock proteins. The molecules are taken from the tumors of patients for a personalized vaccine.

The funding for the new brain cancer vaccine´s second clinical trial was provided through different groups. One of the strongholds was a $1.5 million-a-year grant from the National Cancer Institute. The grant aims to improve studies done in the lab and translate them to measurable benefits´ to a patient´s treatment and progress. Besides the grant from the National Cancer Institute, the research group received support from organizations like the American Brain Tumor Association, Accelerate Brain Cancer Cure, and the National Brain Tumor Society. Following the success of the second clinical trial, the researchers hope to test the effectiveness of combining the vaccine with the drug Avastin.

“It never would have happened without [the organizations],” continued Parsa. “Patient advocacy groups are an important component of how we inform patients about this disease. These groups are also increasingly critical to funding translational research, which bridges the gap between the laboratory and the clinic.”

Ultrasound Treatment Offers ‘Perfect Outcome’ To Prostate Cancer Patients

There´s been another win in the battle against cancer: A new treatment for prostate cancer has been found to not only be highly effective, but to work without debilitating side effects as well.
The new treatment works by heating and killing only the tumor with a high-intensity focused ultrasound (HIFU). This treatment should allow men to only be subjected to an overnight stay in the hospital without any troubling side effects.
A new study of the procedure has shown 9 out of 10 patients have been reported as cancer free with no side effects, something the study calls the “perfect outcome.”
According to Rebecca Smith of The Telegraph, experts are calling these outcomes “very encouraging,” saying it will bring about a “paradigm” shift in the treatment of diseases.
Next week, the National Institute for Health and Clinical Excellence will report their findings in new guidance, saying the new treatment is safe and effective and will call for larger scale trials to begin.
In fact, some trials have already begun, and experts say any man interested in the treatment should contact their doctors.
The treatment can carefully select even small tumors, as small as a grain of rice. Once targeted, the HIFU heats the tumors and destroys them.
As fewer tissues are subjected to the treatment or damaged, the likelihood of side effects are lessened.
A study published in the journal Lancet Oncology tracked 41 men treated with HIFU. A year after their treatment, none of the patients were incontinent and only one in ten suffered impotence, common side effects of other prostate cancer treatments. The majority of these 41 patients, a whopping 95%, were cancer free after 12 months.
Dr. Hashim Ahmed, who led the study at University College London Hospitals NHS Foundation Trust and University College London, said: “This changes the paradigm. By focusing just on the areas of cancer we reduce the collateral damage to surrounding tissue.”
“This study provides the proof-of-concept we need to develop a much larger trial to look at whether focal therapy is as effective as the current standard treatment in protecting the health of the men treated for prostate cancer in the medium and long term.”
Dr. Hashim told the Telegraph once the guidance is issued next week, he expects even more doctors to begin using the treatment.
Professor Gillies McKenna, director of the Medical Research Council and Cancer Research UK Gray Institute for Radiation Oncology and Biology, said: “Clinical trials, like this one supported by the MRC, are a fantastic tool for telling us whether experimental new treatments are likely to be effective in the clinic.”
It´s not just doctors who are thrilled with the results.
One of the patients involved in the trial is 72 year-old Robert Page from Croydon, London. According to BBC News, Page said he had his treatment two years ago, and it´s been a success.
“The outcome was very good,” he said. “I was very pleased with the treatment and very happy with the lack of side-effects, particularly when I contrast that with what might have been the case if I’d had one of the other, alternative, treatments.”

Injections Do Little To Help Those With Chronic Back Pain

Injections of arthritis drugs or steroids in the spine may not do much to help patients with chronic back and leg pain due to nerve damage, according to a new study. Though there were some initial safety concerns about the injections, the study didn´t show an increased risk of infections or other complications. Researchers said the anti-arthritis drug etanercept (sold as Enbrel) may better serve its patients when taken in larger doses, or when taken on an as-needed basis. Enbrel has been prescribed to patients with severe nerve damage, resulting in chronic back and leg pain.

In a report in the Annals of Internal Medicine, the researchers say they couldn´t definitively say whether or not either type of injection would help people with such nerve-related chronic pain. “This kind of pain is very challenging to treat. There´s no reliable treatment that works in everyone,” said Dr. Steven Cohen from the Johns Hopkins University School of Medicine in Baltimore, according to Reuters.

Speaking to Reuters Health, Dr. Cohen said medications do not tend to work very well. Dr. Cohen also said surgeries may offer short term relief, but there was no difference in patients who did and did not have the surgery a few years later.

This back and leg pain due to nerve damage is known as sciata, and until now, patients with sciata have been treated with epidural steroid injections, according to Dr. Cohen. Lately, however, more and more patients have been looking to injections of immune suppressing drugs like Enbrel.

“People are looking for something more effective and something safer,” he said. “The findings are disappointing, but by no means is this the end of the story.”

To conduct his study, Cohen tracked 81 patients in their early 40s for at least one month. These patients were treated at one of four military medical centers and two civilian hospitals.

Cohen then split these patients into three groups. Each group was given a different type of injection: A steroid called methylprednisolone, Enbrel or a saline solution. Neither the patients nor the doctors knew which group was receiving which injection.

When patients checked in a month later, their results were unanimous across the board. Each patient reported similar reduction in back and leg pain, despite which injection they received. Those patients who received saline solutions, however, reported larger improvements in their ability to move around than those who had received the steroid and Enbrel injections.

Dr. Cohen said he was disappointed by the lack of any significant benefit from receiving the Enbrel injections as opposed to a simple saline solution.

“These drugs are expensive, and even though they may be safer than steroids, they´re not devoid of risk,” he said.

Listed anywhere from $500-$700, the steroid and Enbrel injections are not cheap. According to Dr. Cohen, the biggest concern of the Enbrel injections are immune system side effects, while the steroid injections can increase blood sugar levels as well as cause stomach problems.

Dr. Cohen suggests a patient´s behaviors and lifestyle could end up playing a larger role in their sciata treatment.

“The treatment that has the strongest evidence behind it is actually exercise programs,” he said – “as well as losing weight, for people who are too heavy.”

Shuttle Program Honored As Discovery Makes Final Journey

[ Watch the Video ]

Tuesday marked the final flight of NASA‘s oldest surviving space shuttle, as a modified Boeing 747 carrying Discovery lifted off from the Kennedy Space Center in Florida at dawn and transported the vehicle to Dulles Airport just outside of Washington D.C., according to CBS News and various other media outlet reports.

As onlookers watched the flight, which passed by the Potomac River, Reagan National Airport, and the National Mall before reaching its new home at the Smithsonian National Air and Space Museum annex in Virginia, former astronauts, space enthusiasts who grew up along with the shuttle program, and even the National Geographic Society paused to reflect upon and pay tribute to not only Discovery but to the venerable shuttle program as a whole.

This week, National Geographic unveiled a series of interactive GigaPans (gigapixel panoramas) offering shuttle enthusiasts an unprecedented inside look at Discovery, which first launched on August 30, 1984, and its sister shuttles, Endeavour and Atlantis. These interactive digital images contain billions of pixels and provide virtual tours of Discovery’s flight deck, mid-deck, payload bay, tail cone, airlock, flight deck windows, and more — even the shuttle’s toilet facilities!

According to Dave Mosher of National Geographic News, the Society’s photographers were able to take more than two dozen ultra-high resolution, 360-degree photos of Discovery and the other two NASA orbiters. They, along with other new organizations, were granted “unprecedented access to the hundred-ton spaceships” following the program’s final journey, courtesy of NASA and the US space agency’s primary shuttle service contractor, United Space Alliance.

National Geographic Society Vice President of Digital Media Susan Poulton and Freelance Photojournalist Jon Brack had originally planned to use the GigaPan technology to create a couple of panoramic images, Mosher said. However, they ultimately spent 30 hours in all three shuttles, creating a total of 27 gigapans, including “2.74-gigapixel, zoomable images — equivalent in resolution to about 340 pictures taken with an 8-megapixel iPhone camera” of Discovery’s flight deck, the National Geographic News reporter added.

“The space shuttle is something we always see at a distance. It has always been this forbidden place. We wanted to get pics of everything as close as possible, and we knew GigaPan’s high-definition panoramas would allow you to zoom in intimately close,” Brack told Mosher on Monday. “It’s a whole new way to look at these spacecraft.”

After 39 flights, Discovery will be permanently sealed at its new home, Smithsonian Institution’s National Air and Space Museum, which according to Irene Klotz of Reuters is “the nation’s official repository for space artifacts.” Meanwhile, Chip Reid of CBS News reports that space shuttles Enterprise and Endeavor will head to New York and Los Angeles, respectively, while Atlantis will remain at the Kennedy Space Center in Florida.

For many veterans of the shuttle program, Discovery’s last ride marked the end of an era.

“It’s sad to see this happening,” NASA’s Nicole Stott, who was part of the final Discovery crew during the STS-133 mission in March 2011, told Reuters on Tuesday. “But you look at it and you just can’t help but be impressed by it. That’s my hope now, that every time someone looks at that vehicle they are impressed, that they feel that this is what we can do when we challenge ourselves.”

Likewise, former astronaut Mike Mullane, who took part in three shuttle missions, called it “a very emotional, poignant, bittersweet moment“¦ When it’s all happening you think, ℠This will never end,’ but we all move on.”

As previously reported here at RedOrbit, Discovery’s final flight had originally been scheduled for Saturday, April 14. However, that flight was delayed due to wind gusts which kept workers at the Kennedy Space Center from safely mounting the shuttle atop the Boeing 747 Shuttle Carrier Aircraft (SCA) that ultimately transported it to the Smithsonian.

Image Credits: Jon Brack/National Geographic

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April 18: Sleep Apnea Awareness Day

Connie K. Ho for Redorbit.com

18 million. That´s the number of people, and counting, who are believed to have sleep apnea. What´s most shocking is that three-quarters of them don´t even know that they have the disorder. To bring awareness to sleep apnea, the American Apnea Sleep Association (ASAA) has made April 18 Sleep Apnea Awareness Day.

Sleep apnea is a chronic disease where the person´s tongue and soft palate fall against the back of the throat, making it difficult to breathe. The disorder can lead to chronic heart failure, diabetes, hypertension, stroke, sudden death, among other serious effects for adults. For children who suffer from the illness, there may be consequences like hyperactivity and delayed cognitive development.
April 18 was chosen as Sleep Apnea Awareness Day because, in 1981, the British medical journal The Lancet published information regarding Continuous Positive Airway Pressure (CPAP), which revolutionized sleep apnea treatment.

“Every day is sleep apnea awareness day at the ASAA,” said executive director Edward Grandi in a statement. “But we designated April 18th as Sleep Apnea Awareness Day because we believe that educating people about sleep apnea´s dangers is critical.”

Apart from CPAP, another type of treatment is neurostimulation. Described as the “pacemaker for the tongue,” it´s for people who have tried CPAP but haven´t had any success. ImThera Medical, a company based in northern California, began developing the product in 2008 and has seen success for its patients. Marcello Lima, the CEO of ImThera Medical, described how CPAP could be cumbersome to wear for some patients as it included a mask and ventilator.

Lima was first encouraged to look into neurostimulation and alternative therapies after seeing how his wife´s younger brother, who is a severe apnea patient, couldn´t adjust to CPAP.

“Alternative therapy is in clinical trials to help these patients who can´t comply to CPAP, explained Lima. “It´s important to know that there are alternative therapies close to commercialization, at least in Europe. I think that alternative therapy may help many who fail CPAP.”

Lima highly encourages people or their partners to seek a physician or general practitioner’s diagnosis if they believe that they suffer from sleep apnea. Doctors can administer the appropriate tests, determine if a patient has sleep apnea, and analyze the level of sleep apnea. The variety of symptoms can range from frequent and loud snoring to feeling exhausted after sleeping.

Tai Chi Wheelchair Brings Mobility, Self-Esteem, Better Health To Practitioners

Wheelchair Tai Chi featured in 2008 Beijing Olympics

An innovative 13-postures Tai Chi designed for wheelchair users is described in the current issue of Technology and Innovation- Proceedings of the National Academy of Inventors®.

The innovation has brought the traditional Chinese martial and healing arts to people with ambulatory impairment, thanks to the technology and program developed by Zibin Guo, PhD, of the University of Tennessee Chattanooga.

“Too often, social and cultural barriers discourage people with physical disabilities from participating in fitness activities,” said Zibin Guo, PhD, who collaborated with the China Disabled People’s Federation and the 2008 Beijing Paralympics Committee to introduce the Tai Chi Wheelchair at the 2008 Beijing Olympics/Paralympics Cultural Festival. “Wheelchair Tai Chi can be practiced seated for those needing simple, low-impact, upper-body exercise by integrating wheelchair motion with the gentle, dynamic flowing movements of Tai Chi. It lifts the spirit and give practitioners a sense of command of space.”

The 13 Posture Wheelchair Tai Chi incorporates 13 of the 24 Tai Chi movements and, according to Dr. Guo, the 13 Postures of Wheelchair Tai Chi transforms the wheelchair from an assistive device to a tool of empowerment and artistic expression.

A demonstration event from the 2008 Beijing Olympics/Paralympics Cultural Festive can be seen on YouTube at http://www.youtube.com/watch?v=jR0DbXlS4GI

Tai Chi (Taijiquan) has been part of Chinese traditional medicine for thousands of years, but has not been an accessible form of martial arts, therapy or exercise for those with disabilities. Dr. Guo estimates that 83 million people in China are living with disabilities, particularly those disabilities that limit mobility. Most of the 83 million live in rural China where “social and economic development lags behind urban areas,” he said.

He also cites a National Health Interview Survey that suggests that about 73 percent of people in the U.S. with disabilities have no or infrequent physical activity.

“Studies conducted in China and elsewhere suggest that these individuals, and especially wheelchair users, have significantly lower self-esteem and are more vulnerable to depression,” explained Dr. Guo. “The rationale behind developing Wheelchair Tai Chi as a fitness and recreational alternative for people with ambulatory impairment was first based on the documented benefits of Tai Chi in terms of health, accessibility, low cost and acceptance in the popular culture. Second, it was based on the perceived benefits for health and fitness that a modified Tai Chi could have for people with ambulatory impairment.”

Wheelchair Tai Chi movements allow a wide range of lower back and hip movements, said Dr. Guo. Also, the movements help promote upper body mobility and internal circulation. Vertical and horizontal circles improve and stimulate the rotation and range of motion for the torso, waist, back, shoulders, arms and wrists.

“The slow, guided muscle movement has a way of helping to reinforce the muscle patterns that may not have been present before,” said Dr. Glen F. Haban, a neuropsychologist at Siskin Hospital for Rehabilitation in Chattanooga when commenting on early clinical studies related to Wheelchair Tai Chi.

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Infants Calm Faster With The Five S’s After Vaccinations

Taking your infant to the doctor´s office for vaccinations and tests can be a harrowing experience for the parent and the child. However, there are ways to ease the shock of the needle, at least for the child.
Experts are recommending that the “5 S´s” be used on the frightened child immediately afterwards. A study published this week in the journal Pediatrics finds that swaddling, side/stomach position, shushing, swinging and sucking, go a long way towards easing the pain, reports Rita Rubin for MSNBC.com.
Pediatrician John Harrington of Children´s Hospital of The King´s Daughters in Norfolk, Va., who led the study says, “Some parents might be a little skittish giving their babies vaccines knowing it´s not painless.” But that should not prevent parents from getting these important shots. “They can do something to reduce the pain and soothe their child.”
The 5 S´s grew out of the realization that babies are born with a calming reflex, says Harvey Karp, an assistant professor of pediatrics at the USC School of Medicine, and author of the book and DVD, The Happiest Baby on the Block.
By replicating the womb environment — “a symphony of sensations, noise, jiggly movements and touching” — caregivers can quickly put babies in the calm zone, he told Rubin.
“Parents do many of these things intuitively, but they may not be doing them correctly,” Karp says. “You have to do them (5 S´s) exactly right, or they don´t work.” For example, he says, the swaddling must be tight, and the shushing has to be pretty loud (think about how a vacuum cleaner can calm a crying baby).
“There´s been 30 to 40 years of research showing the individual S´s work, but what was missing was the recognition that babies are born with a reflexive-off switch for crying and an on-switch for sleeping.”
The study enrolled 230 2-month-old and 4-month-old babies and randomly divided them into four groups: After their shots, they either got the 5 S´s or their parent´s standard comforting care, and they received plain water or sugar water, reports Claire Bates for Daily Mail.
The infants were given three shots in alternating thighs and were then swaddled in under 15 seconds and provided at least three of the other 5 S´s within 30 seconds of the shots (some of the babies calmed down before sucking on a pacifier, the 5th S, or were unaccustomed to using one).
The babies´ pain was rated by the residents, based on how hard they were crying and their facial expressions, immediately after the third shot and continued for two to five minutes.
The 5 S´s calmed the babies significantly better than the parents´ efforts, whether or not sugar was added to the mix, writes Medical News Today.
Harrington´s team might have seen the 5 S´s calm the babies even more quickly if they´d swaddled all but one leg before administering the shots, Karp says.
“I think the nice thing that came out of this is when we did the 5 S´s after the shots, the parents wanted to learn,” Harrington says. Unfortunately, as many parents might have noticed, the calming reflex goes away after about three months, Karp says, and Harrington found the 5 S´s didn´t work as well with 4-month-olds as with 2-month-olds.

CDC Report Highlights Decrease In Children’ Deaths By Unintentional Injury

Connie K. Ho for RedOrbit.com

A new Vital Signs report from the Center of Disease Control and Prevention (CDC) states that 9,000 children died due to unintentional injury in 2009. Though this number is quite high, it is still an improvement from previous years. The research by the CDC found that the death rates from unintentional injuries among children and adolescents decreased by almost 30 percent from 2000 to 2009.

The CDC Vitals Report appears monthly in the CDC journal Morbidity and Mortality Weekly Report. According to MSNBC, the CDC looked at death certificates from those as young as newborns to those who are 19-year-olds. The report analyzes causes of unintentional injury, including deaths due to car accidents, fires, falls, among other issues. Even though crashes remain the number of cause of unintentional injuries, the number of deaths from motor vehicle accidents declined by 41 percent. This decrease has been attributed to better booster seat uses, changes in drivers´ license licensure for teenagers, and general improvements in child safety.

“Kids are safer from injuries today than ever before. In fact, the decrease in injury death rates in the past decade has resulted in more than 11,000 children´s lives being saved,” commented CDC Director Thomas Frieden, M.D., M.P.H, in a preparement statement. “But we can do more. It´s tragic and unacceptable when we lose even one child to an avoidable injury.”

While there is a decrease in the number of deaths by unintentional injury, there has been a rise in suffocation rates (a 54 percent increase among infants less than a year old) and poisoning rates (a 91 percent increase among teens between the ages of 15 and 19) due largely to prescription drug overdoses. Based on research, the CDC recommends that there be appropriate prescribing of medication, proper disposal of pills, and instatement of state-based prescription drug monitoring programs to decrease the number of prescription drug related deaths. According to CBS News, the American Academy of Pediatrics also advises creating a safe space for infants to sleep comfortably in a crib.

“Every 4 seconds, a child is treated for an injury in the emergency department, and every hour, a child dies as a result of an injury,” said Linda C. Degutis, Dr. P.H., M.S.N., director of CDC“²s National Center for Injury Prevention and Control. “Child injury remains a serious problem in which everyone —including parents, state health officials, health care providers, government, and community groups — has a critical role to play to protect and save the lives of our young people.”

In 2009, child injury death rates also varied by state; while there were less than five deaths for every 100,000 children in Massachusetts and New Jersey, there were more than 23 deaths for every 100,000 children in South Dakota and Mississippi.

The CDC is partnering with over 60 different organizations to release a National Action Plan on Child Injury Prevention that will correspond with the Vital Signs report. The goals of the National Action Plan include raising awareness about the issue of child injury, highlighting prevention solutions, and mobilizing action to coordinate a national effort to reduce child injury.

Brides Resort To Extreme Measures To Lose Weight

Connie K. Ho for RedOrbit.com

A new trend, the Ketogenic Enteral Nutrition (KE) diet, has been taking the bridal world by storm. Women from all over the global who are interested in losing weight in a short amount of time are turning to this quick weight loss style. It´s proven effective in results, but is also controversial in method. Apart from medical treatments, brides to be are looking at other pricey ways they can slim down in time for their big day.

The tube diet had previously been seen in areas like the United Kingdom and Europe, a final resort for women who wanted to lose weight quickly. Describing the KE diet to ABC News, Dr. Oliver Di Pietro of Bay Harbor Islands, Florida, explained how patients are “fed a constant slow drip of protein and fat, mixed with water, which contains zero carbohydrates and totals 800 calories a day. Body fat is burned off through a process called ketosis, which leaves muscle intact.”

“It is a hunger-free, effective way of dieting,” remarked Di Pietro in the interview with ABC News. “Within a few hours and your hunger and appetite go away completely, so patients are actually not hungry at all for the whole 10 days. That’s what is so amazing about this diet.”

Jessica Schnaider of Surfside, Florida, underwent the treatment in March before her wedding. She felt it would help her save time and decided to try it out. During her ten day treatment, she didn´t feel hungry but admitted to having to adjust emotionally to the procedure.

“I was tired. I didn’t feel like exercising. The doctor told me that if you can compliment with walking for a half an hour on the beach, that would be great, but I didn’t feel like doing that. I’m a very energetic person, but those days I was a little tired,” said Schnaider in an interview with ABC News.

Besides these various weight loss formulas, some brides are purchasing special training packages with fitness trainers who specialize in helping them lose weight right before the wedding.

“I´ve been training brides for 12 to 13 years, and the typical weight loss is 15 to 20 pounds,” commented Sue Fleming, the author of Buff Brides who charges $140 to $200 a session, in an article by the New York Times.

Some in the medical profession question fad diets and recommend that patients take extra precaution.

In an interview with the New York Times, Dr. Scott Shikora, the director of the Center for Metabolic Health and Bariatric Surgery at Brigham and Women´s Hospital in Boston, stated that “Putting a tube in one´s nose, it´s not always comfortable and pleasant. And this has to be medically supervised.”

Others are skeptical about products, like BluePrintCleanse organic drinks, that promise to cleanse the body of toxins like a laxative.

“Do you notice they never tell you what the toxins actually are?” piqued Dr. David Gorski, an associate professor of surgery at Wayne State University in Detroit, in a New York Times article. “There´s no science to back them up.”

Medical professionals also question the role that pop culture has on consumers, with many celebrities starting and popularizing the various weight loss methods.

“Celebrities are not known for doing things that are necessarily the healthiest or most sensible in many parts of their lives,” explained Dr. Louis Aronne, the director of the Comprehensive Weight Control Program at NewYork-Presbyterian/Weill Cornell Medical Center, in the New York Times. “Nutrition should probably be included in that.”

Psychoanalyst Bethany Marshall of Beverly Hills, California commented on the need to be aware of not only physical side effects but also the mental side effects of this quick fix weight loss technique.

“If you lose the weight too quickly your mind is not going to be able to catch up with a newer, skinnier you,” noted Marshall of Beverly Hills, California, in a report by ABC News.

Scientists Identify Genes That May Impact Alzheimer Patients’ Brains

Researchers have identified four genes that are associated with decreasing size of the hippocampus, a finding that may have impacts with studying Alzheimer’s disease.

The hippocampus is one of the brains regions involved with short and long-term memory processes.  It is also one of the first regions of the brain to exhibit damage from Alzheimer’s disease.

A team of over 200 scientists from 100 institutions around the world collaborated to map the human genes that boost or sabotage the brains’ resistance to a variety of mental illnesses and Alzheimer’s.

Paul Thompson, professor of neurology at the David Geffen School of Medicine at UCLA and a member of the UCLA Laboratory of Neuro Imaging said they searched for two things during the study.

“We hunted for genes that increase your risk for a single disease that your children can inherit,” Thompson said in a press release. “We also looked for factors that cause tissue atrophy and reduce brain size, which is a biological marker for hereditary disorders like schizophrenia, bipolar disorder, depression, Alzheimer’s disease and dementia.”

The team recruited brain-imaging labs around the world to pool their brain scans and genomic data, helping them create “Project Enhancing Neuro Imaging Genetics through Meta-Analysis”, or ENIGMA.

The researchers measured the size of the brain and its memory centers in thousands of MRI images from 21,151 healthy people while simultaneously screening their DNA.

“Earlier studies have uncovered risk genes for common diseases, yet it’s not always understood how these genes affect the brain,” Thompson said in the press release. “This led our team to screen brain scans worldwide for genes that directly harm or protect the brain.”

The team was looking for whether any genetic variations correlated to brain size, specifically gene variants that deplete brain tissue.

They found a consistent relationship between subtle shifts in the genetic code and diminished memory centers.  They also found the same genes affected the brain in the same ways in people across diverse populations from Australia, North America and Europe.

“Millions of people carry variations in their DNA that help boost or lower their brains’ susceptibility to a vast range of diseases,” Thompson said. “Once we identify the gene, we can target it with a drug to reduce the risk of disease. People also can take preventive steps through exercise, diet and mental stimulation to erase the effects of a bad gene.”

They identified four genetic loci, including seven genes in or near these loci that appear to determine hippocampal volume.

The results show that if one gene is altered, the hippocampus is the same size as that of a person four to five years older.

The investigators also discovered the genes that explain individual differences in intelligence.  They found a variant in a gene called HMGA2 that affected brain size as well as a person’s intelligence.

“This is a really exciting discovery: that a single letter change leads to a bigger brain,” said Thompson. “We found fairly unequivocal proof supporting a genetic link to brain function and intelligence.”

The research was published in the online edition of Nature Genetics on April 15.

Electrodes Implanted In The Brain Could Cure Depression

A new and radical breakthrough procedure may help doctors treat depression in their patients with the use of electrodes.

Implanting electrodes in the brains of patients who suffer depression has been shown to be very effective, but is only recommended for patients who found no help with prescription medications.

Now, after years of positive results from early field trials, Helen Mayberg, the neurologist pioneering this new treatment, is seeking FDA approval.

The treatment is known as “Deep Brain Stimulation,” (DBS) and has been used for over a decade to treat some movement disorders, such as Parkinson´s disease. Deep brain stimulation is quite invasive, but Dr. Mayberg believes inserting the electrodes in the brain of the depressed patients could relieve their suffering.

The treatment involves drilling two very small holes into the skull, then inserting small, battery-powered electrodes into the brain. Doctors can then send a very small electrical current to the brain, about a thousandth of the power used to light a flashlight bulb.

Dr. Mayberg says the procedure is targeting a small part of the brain, no larger than a pea, called Area 25. This area is crucial in affecting people´s moods.

Each electrode has 4 contacts which can be independently controlled with various levels of electricity. To determine the best place to plant the electrodes, the doctor and patient have to go through a test of trial and error. The doctor will move the electrode around the small area and ask the patient to describe what area feels best on a scale from 1 to 10.

Patients who volunteered to go through with the procedure instantly became more uplifted. One patient even began to spontaneously talk about blooming flowers and the symbol of rebirth and renewal in spring.

Speaking to Dr. Sanjay Gupta and Andy Segal of CNN, Dr. Mayberg said the first tests in Toronto in 2003 were emotionally overwhelming for her, and though she tried to remain an impartial scientist, she couldn´t always hold back the tears.

“I did a lot of crying,” she said.

One of Dr. Mayberg´s greatest success stories from the surgery is Edi Guyton, a college professor who has struggled with depression ever since she was a teenager. While in college, Guyton found the depression to be too much to handle, and tried to kill herself by slitting her wrists. She tried again years later as the chair of the early childhood education department at Georgia State University.

After 22 years at GSU, Guyton retired early and tried to beat her depression. When she heard about Dr. Mayberg´s work with DBS, she signed up to be a volunteer for the procedure.

To determine if they genuinely felt better or just believed in the procedure as a placebo effect, some of the patients were told their battery packs would be turned off, while some patients had their packs remain on.

Guyton had her packed turned off, and her depression returned quickly. Now, according to a psychological test called the “Hamilton Rating Scale for Depression,” Guyton´s depression is in remission thanks to the new surgery.

Dr. Mayberg now hopes to better understand how and why the DBS procedure works as well as it does.

“To be brutally honest, we have no idea how this works,” Mayberg told CNN.

25% Of Grandparents Leave Prescriptions Within Reach Of Grandkids

Two-thirds of adults support single-dose packaging to avoid accidental poisoning, according to U-M’s National Poll on Children’s Health

Unintentional poisonings from medicines cause more emergency room visits for young children each year than do car accidents.

One key reason may be that nearly 1 of every 4 grandparents says that they store prescription medicines in easy-access ways, according to a new poll.

The University of Michigan Mott Children’s Hospital National Poll on Children’s Health recently asked parents and grandparents of children aged 1 to 5 years about the presence of medicines in their homes and how they are stored.

“Every 10 minutes a young child in the U.S. is taken to the emergency room because of possible poisoning from swallowing a prescription medicine or over-the-counter medicine,” says Matthew M. Davis, M.D., M.A.P.P., director of the C.S. Mott Children’s Hospital National Poll on Children’s Health.

“Emergency room visits for accidental poisonings among young children have become much more frequent in the last decade. We hope the results of this poll are a reminder to parents, grandparents and all those who care for young children: check around your homes to make sure that medicines are safely stored out of reach,” says Davis, who also is associate professor in the Child Health Evaluation and Research Unit at the U-M Medical School, and associate professor of Public Policy at the Gerald R. Ford School of Public Policy.

The poll results showed 23 percent of grandparents and 5 percent of parents reported storing prescription medicine in easy-to-access places, including daily-dose boxes that children can open. Eighteen percent of grandparents and 8 percent of parents said they store over-the-counter medicines in easily accessible spots.

The most common type of prescription in an accidental ingestion for young children is an opiate medicine, such as a morphine-related painkiller. The most common types of over-the-counter medicines that prompts emergency room visits for possible poisonings among young children include acetaminophen, used to reduce fever.

To keep children safe, parents and grandparents are generally urged to keep medicine safely out of reach of young children, in child-proof containers.

But the poll also found that about two-thirds of adults say they would support new laws that would require companies to create single-dose packages of tablets, capsules and liquid medicines that would make it harder for young children to ingest large quantities.

“The support for potential new requirements for single-dose dispensing of medicine in solid and liquid format is quite strong. However, there may be barriers to passage of such legislation — not the least of which are environmental concerns about increasing packaging,” says Davis.

On The Net:

Asian Glaciers Bulk Up, Confusing Researchers

Bucking the global trend, some Asian glaciers on Karakoram´s mountains are getting thicker, according to researchers.

A French team used satellite images to show that the Karakoram glaciers, located west of the Himalayan region, were putting on mass.

It is still unclear why these glaciers are gaining weight. The glaciers in other parts of the Himalayas are following the global trend and losing mass.

The glaciers in this region remain poorly studied, despite the fact they provide water for more than a billion people.

A report from the Intergovernmental Panel on Climate Change (IPCC) in 2007 claimed most of the ice in this region could disappear by the year 2035. Since then, this glacier has been a hot topic of debate amongst researchers and scientists.

The Karakoram range is technically a separate range from the Himalayas and includes the world´s second-highest peak, K2.

The French team responsible for the new research conducted the study in response to a call for more thorough observations of this inaccessible region.

The team of scientists, from the National Centre for Scientific Research (CNRS) and the University of Grenoble, compared two models of land surface elevation taken from satellites in 1999 and 2008. They reported their findings in Nature Geoscience.

This isn´t the first time this method of comparing satellite models has been used, however.

“It´s not been used more because these elevation models are quite difficult to acquire – you need clear sky conditions and reduced snow cover,” said lead researcher Julie Gardelle, speaking to BBC News reporter Richard Black.

When all the calculations were complete, the team found the mass of the glaciers had increased marginally in between 1999 and 2008. Individual glaciers, however, showed wide variations in their size.

It is not yet clear why these glaciers are growing, if only marginally so, while other glaciers are losing their mass. Other studies have shown climate change in other parts of the world can cause extra precipitation in colder regions. If this precipitation falls in areas cold enough, it will be added to the existing mass of ice.

“We don´t really know the reason,” Ms Gardelle told Black. “Right now we believe that it could be due to a very specific regional climate over Karakoram because there have been meteorological measurements showing increased winter precipitation; but that´s just a guess at this stage.”

Other parts of the wider Himalayas-Hindu Kush region are not sharing in this growth trend, which is startling considering these glaciers provide fresh water for an estimated 1.3 billion people living in the river basins below.

The Kathmandu-based International Centre for Integrated Mountain Development (ICIMOD) provided data late last year showing the rate of ice loss across 10 regularly studied glaciers has doubled since the 1980s.

The ICIMOD also noted how sparse the data from this region can be. Out of the 54,000 glaciers in the region, only 10 were studied regularly. According to measurements taken by the GRACE satellite mission, which can detect variations in the Earth´s gravitational pull, there has been a net loss of mass across the entire region of glaciers. Graham Cogley, a scientist from Trent University in Ontario, Canada first publicly the IPCC´s 2035 figure. He seems less than optimistic when it comes to determining the how much mass has been lost, saying it “will keep glaciologists busy for some time”.

Image Caption: Baltoro Glacier In the Karakoram. Credit: Grazyna Niedzieska/Getty Images

Solving A 700 Million Pig Problem

Australian science is helping to solve one of China´s biggest and smelliest problems — what to do with the waste produced by its 700 million pigs.
Working with Chinese scientists and technology firm HLM Asia Ltd, Australia´s CRC for Contamination Assessment and Remediation of the Environment (CRC CARE) has helped develop novel digester technology to help deal with the estimated 1.4 million tons of manure and 7mt of urine produced by the burgeoning Chinese pork industry annually.
CRC CARE managing director Professor Ravi Naidu said the new technology can produce clean energy (biogas), fertilizer and other valuable products from nutrient-rich waste, in a system with great potential for application in other industries worldwide.
China has 700 million pigs in 1.8 million farms, which supply two thirds of the country´s rapidly-growing meat consumption. “However these piggeries also produce enormous volumes of waste, only a tenth of which is currently being treated,” he explains.
Despite tighter regulations, large amounts of nitrogen, phosphorous and contaminants are being discharged into the environment where they damage ecosystems and pose a threat to human health. The nutrients lost in the waste of one pig alone are worth about $50 a year, but there is no technology in place yet to recover and use this vital resource.”
Prof Naidu says the joint project has developed a two-step underground anaerobic bioreactor for treating piggery waste, and established the settings for load and digestion time. It has identified a particular combination of anaerobic treatments that can recover the nutrients and produce clean biogas energy as well.
“The technology has been demonstrated in the field and is now being scaled up to treat large volumes of wastes from a number of piggery farms,” he says.
The technology is expected to have widespread application not only in China but throughout Asia, wherever animals are farmed intensively, and to create fresh export opportunities for Australian technology solutions to similar contamination problems.
In this project the CRC is providing scientific expertise, including supervision of six PhD students at Huazhong University of Science and Technology in Wuhan Province with links to research skills at the University of South Australia.
The project is being managed by HLM Ltd on the ground, taking advantage of the relatively low cost of technology trials and scale-up work in China. “It´s a perfect partnership between Australian science and Chinese technical expertise,” he says.
Professor Naidu explains that the main scientific and technical challenges solved by this project are the high N and P loads in pig waste compared with domestic sewage, the current small size of biogas reactors, their slow rate of digestion, the limiting influence of temperature, and the presence of heavy metal contaminants which restrict the use of residues as fertilizer.
So far, the technology has been able to overcome each of these, and is now moving to full-scale trials.
“The market for a successfully packaged solution to this suite of problems is clearly very large — both in Asia and around the world. Besides handling livestock wastes, similar bioreactor technology can be used to manage and cleanse the runoff from urban landfills and organic waste streams from other industries,” Prof Naidu says.
“We anticipate that the scientific and technical knowledge gained in the course of CRC CARE´s research will have real value for Australia´s intensive livestock and food industries — and will help protect our environment from these types of wastes.
“At the same time we are producing a new source of clean energy for industry or domestic use, and a vital supply of nutrients to help secure the future of food production.”

On the Net:

Menthol Cigarettes Increase Stroke Risk

New research shows that smoking menthol cigarettes can increase the risk of stroke in addition to the myriad of other health risks of smoking.

Nicholas T. Vozoris, M.H.Sc., MD, from St. Michael´s Hospital in Toronto conducted the study which was published this week in the Archives of Internal Medicine. Working with data from the US National Health and Nutrition Examination between 2001 and 2008, Dr Vozoris investigated the link between smoking mentholated cigarettes and the risk of cardiovascular and pulmonary disease. More than 5,000 people over the age of 20 were a part of the study.

Around one quarter of the subjects involved in the study were menthol smokers, giving Dr. Vozoris a comparison between the two types of smokers. According to his results, menthol smokers were more than twice as likely to suffer a stroke. The risk of stroke rose in women, who were 3 times more likely suffer a stroke.

The research didn´t reveal any information as to why the menthol cigarettes increased the risk of stroke, noting women and “non-African Americans” in particular face an even higher risk.

“They´re all bad, but having said that, from a harm-reduction perspective this study does lend to the view of avoiding – at a minimum – mentholated types,” said Dr. Vozoris in his report.

Some experts blame underage smoking on these menthol cigarettes, saying it makes smoking easier to start and harder to quit as menthol flavor helps ease the harshness of the tobacco.

Dr. Vozoris isn´t yet convinced this study proves there is a direct link to smoking menthols and strokes. Instead, he says there could be some other unmeasured differences between menthol and non-menthol smokers causing the increased risk.

In addition, Dr. Vozoris wasn´t sure why the study showed women and non-African Americans at a higher risk than the others. According to Medical News Today, Dr. Vozoris said of the study, “Although potential causal links cannot be established and further research is required to confirm the findings, the association between mentholated cigarette smoking and stroke is noteworthy, given that the results are based on large population-level data, with data spanning nearly a decade, and given that the relationship is independent of multiple sociodemographic, smoking behavior, and health status confounders.”

The study did not find a link between smoking menthols and an increased risk of high blood pressure, congestive heart failure or chronic lung disease. This surprised Gordon Tomaselli, president of the American Heart Association and chief of cardiology at Johns Hopkins University School of Medicine. He told Reuters reporter Andrew Seaman that it was interesting the study showed an increased risk of stroke but not high blood pressure.

Dr. Vozoris suggests the reason the risk of stroke is higher in menthol smokers could be in the effect the menthol has on the vessels delivering blood to the brain.

Smoking has well been documented to have terrible effects on the body. According to the US Centers for Disease Control and Prevention, smoking any kind of cigarette can increase a person´s risk of heart disease anywhere from 2 to 4 times more than someone who does not smoke.

According to Reuters, Tomaselli added, “(This) reminds us that the effects of cigarette smoke is pretty broad-based and (it affects) a number of organ systems.”

Huntington’s Disease May Lower Risk Of Cancer

A Swedish study has shown that people with Huntington´s disease may have protection from cancer. The study also suggests there may be a genetic mechanism in diseases such as Huntington´s capable of fighting off cancer cells.

Huntington´s is a debilitating brain condition and belongs to a group of illnesses known as polyglutamine (polyQ) diseases. These diseases are rare and all share a common genetic trait, which causes the repetition of certain genetic elements.

This repetition produces faulty proteins which then build up inside the cells, thus causing damage.

The new study was led by Dr. Jianguang Ji from Lund University and Skane University Hospital.

Dr. Ji is suggesting more research be done into the specific mechanism that lowers the risk of cancer. Once this research is complete and the specific mechanism of polyQ diseases singled out, doctors and scientists may be able to use it to fight off cancer in other patients.

In addition to Huntington´s, the polyQ diseases are spinobulbar muscular atrophy (SBMA), dentatorubral and pallidoluysian atrophy, and six types of spinocerebellar ataxia.

To conduct the study, Dr. Ji´s team studied 1,510 patients with Huntington´s disease, 471 with SBMA, and 3,435 with dentatorubral and pallidoluysian atrophy, all over a 50-year span.

The scientists found Huntington´s disease patients were 53% less likely to contract a form of cancer than a patient without the polyQ disease, and those with SBMA were 35% less likely to contract cancer.

During the course of their study, 91 patients with Huntington´s disease (or 6%) were diagnosed with cancer, while 34 SBMA patients (7%) and 421 hereditary ataxia patients (12%) were diagnosed with cancer.

According to cancerresearchuk.org, the authors of the study summed up their conclusion this way: “Our findings suggest a common mechanism in patients with polyQ diseases that protects against the development of cancer, and expansion of the polyglutamine tracts seems likely. Future studies should investigate the specific biological mechanisms underlying the reduced cancer risk in patients with polyQ diseases.”

Senior science information officer at Cancer Research UK Eleanor Barrie thought the study to be interesting, saying, “It´s not clear how the genetic changes that cause Huntington´s and other similar diseases could protect against cancer, and research in the lab will help to find out more.”

Huntington´s disease, or HD, is listed as a neurodegenerative genetic disorder, affecting muscle coordination. The most common symptom of HD is involuntary muscle movements, such as writhing or jerking. These movements are known as chorea. The physical symptoms of HD can occur at any time in the patient´s life, though they usually begin between the ages of 33 and 45.

In its early stages, HD can cause those with the disease to experience subtle changes in their coordination, irritable moods, and difficulty thinking through problems and processes.

In the middle stages of HD, chorea becomes more pronounced and may become an issue for these patients. During this stage, occupational and physical therapists may be needed to help a patient through their day.

In the late stages, HD patients rely completely on others for their care, as they can no longer walk or speak. Those with HD typically pass from complications from their symptoms rather than the disease itself.

DNA Sequence Finds Endangered Animals In Traditional Chinese Medicines

Researchers at Murdoch University have revealed the composition of traditional Chinese medicines (TCM) through DNA sequencing technology.
They found that some of the 15 TCM samples tested contained potentially toxic plant ingredients, allergens, and traces of endangered animals.
“TCMs have a long cultural history, but today consumers need to be aware of the legal and health safety issues before adopting them as a treatment option,” Dr Bunce, research leader and Murdoch University Australian Research Council Future Fellow, said in a press release.
The samples of the medicine were seized by Australian border officials in the form of powders, tablets, capsules, flakes, and herbal teas.
The team said they found 68 different plant families in the medicines, some of which contained plants of the genus Ephedra and Asarum.
“These plants contain chemicals that can be toxic if the wrong dosage is taken, but none of them actually listed concentrations on the packaging,” Bunce said. “We also found traces from trade restricted animals that are classified as vulnerable, endangered, or critically endangered, including the Asiatic black bear and Saiga antelope.”
DNA sequencing has made it possible to determine the biological origins of ingredients contained within TCMs because processing into pills and powders makes identification difficult.
“The approach has the ability to unravel complex mixtures of plant and animal products,” PhD student Megan Coghlan, who is studying the application of DNA techniques in wildlife forensic applications, said.
She said that research shows that second-generation, high throughput sequencing is an efficient and cost-effective way to audit the species composition.
The TCMs industry has increased to hundreds of millions of dollars per year, putting a strain on the endangered animals found in the medicines.
“We found multiple samples that contained DNA from animals listed as trade-restricted according to the Convention on International Trade in Endangered Species Legislation. Put simply, these TCMs are not legal,” Coghlan wrote.
Consumers are not aware of the presence of the endangered species, or the toxic plants, because of the mislabeling of TCMs.
“A product labeled as 100 per cent Saiga antelope contained considerable quantities of goat and sheep DNA,” Bunce said. “Another product, Mongnan Tianbao pills, contained deer and cow DNA, the latter of which may violate some religious or cultural strictures.”
He said he hopes the new approach to genetically audit medicinal products will help bring a new level of regulation to the traditional Chinese medicines.
“Auditing TCMs would assist in prosecuting individuals who seek to profit from the illegal trade in animal products,” Bruce said in a statement.
Bruce said he and his team plan to expand the use of these new DNA tests to evaluate other herbal medicines.
The results of the DNA sequencing were published in the journal PLoS Genetics.

Can Supply-Side Economics Solve Global Pollution Problems?

Michael Crumbliss for Redorbit.com

An alternate solution for managing fossil fuel emissions and climate change was released this week by Bard Harstad of Northwestern University´s Kellogg School of Management. The study, titled “Buy Coal, A Case for Supply-Side Environmental Policy,” proposes that known but unexploited fossil fuel deposits can be bought by climate coalition (first-world) countries and kept out of the market. The unused deposits in question are those in third-world countries that often are extracted and consumed with little or no regard for global effects.

This has long been a problem with efforts to control climate change. When climate coalition countries reduce demand and the price of fossil fuels go down, the third world countries that were exporting find the lower price an incentive to keep the fuel at home and increase their own use and emissions. This effectively nullifies any improvement from the climate coalition efforts.

In the long view it may be globally counter-productive to reduce demand in the first world and raise it in the third, because during these times of low prices third world economies create higher patterns of use and increase their own dependence. These changes continue at least to some degree after the price goes up again and could become permanent.

Harstad suggests that the market could be modified from the supply side as well as the demand side:

In my analysis, I show that by letting coalition countries buy extraction rights in third countries — and preserve rather than exploit the fuel deposits — climate coalitions can circumvent the traditional problems of a demand-side policy, the most intuitive benefit from this policy is that emission is reduced if one buys and conserves deposits. Furthermore, the coalition finds it cheapest to buy the marginal deposits (ie, deposits that are not very profitable to exploit, but still quite polluting when consumed).”

By targeting cheaper marginal deposits that are difficult to extract, and which require the most extreme and destructive mining and drilling techniques, costs of buying reserves are kept down and benefit is multiplied. Not only is the fuel kept out of the market, strip-mining and other high-energy and high-emission extraction is avoided. World prices are equalized and third world countries are encouraged to invest in renewable energy, effecting social change as well as environmental progress. In effect the countries that are not participating in the climate coalition become part of the larger effort.

This supply-side system resembles the long standing policies of subsidizing agriculture in the Western world. These governmental subsidies are paid to both small farmers and large agribusiness companies to manage the supply of agricultural commodities like wheat, corn, cotton, sugar, milk, fish, beef, soybeans, etc. In doing so governments regulate the price of these commodities, protect the income of producers and manage supply.

Due to their longevity and history, agricultural subsidies serve as an example of supply side market management. The subsidies are effective in controlling price, but are expensive. Europe is perhaps the best example as the European Union spans the commodity use and economies of many countries, as is suggested in Harstad´s supply-side management of fossil fuels. In 2010 the European Union spent 39 billion euros on subsidies, approximately 40% of the EU budget. In the opinion of some these agricultural subsidies are a crushing burden on the government. It is likely that agricultural subsidies will be cut back in the near future in the US and around the world.

The global market for fossil fuels is much larger and presumably more difficult to manage from the supply side, at least until the fuel runs out, thus accomplishing the same goal with likely catastrophic consequences. The problem raised by Harstad is not new, and it is a large question whether it is possible to effect the fossil fuel production or consumption of these countries in any significant way. The market inertia may be simply too great and expensive a hurdle.

For example, the people of Nigeria came near to revolt last month when the subsidies that keep their fuel prices artificially low were revoked. In the simplest terms it seems that they are going to increase use no matter what we do. Harstad´s theory looks good on paper and is well-intentioned, but may not be possible to practically apply.

Fossil fuel use is increasing all over the world; and third-world countries that have reserves and possibly little else are not going to stop producing and selling these resources. Don Blankenship, CEO of Massey Coal confirms that “predicted coal use will increase by 81 percent in ’emerging’ countries and 1 percent in developed countries by 2035. Brazil, Russia, India and China, which make up 43 percent of the world’s population, will account for much of that growth,” he said.

It is likely that third world countries will continue to gladly provide the coal and oil for this demand. Harstad´s supply side premise for controlling the fossil fuel reserves and consumption of third world countries holds some promise, and is a possible tool that should be examined.  But without an effectively unlimited amount of capital from first world countries it is unlikely that it can be put into practice at a scale that would change current markets.

Real Words vs. Non-Words, Baboons Know The Difference

Lawrence LeBlond for RedOrbit.com

The results of a new study reveal that baboons have the ability to discern real English words from fake words just by looking at them, suggesting that some mental processing involved in reading evolved separately from the specialized language centers that are unique to the human brain, scientists reported on Thursday.

Researchers at Aix-Marseille University in France, led by Jonathan Grainger, said their findings suggest that reading is based on simple object-identification skills, rather than on more advanced linguistic skills.

The finding points to one of the key elements of human reading. Children learn the sounds of their ABCs before learning to read, but recognizing word shapes and lengths also plays a much stronger role in literacy, based on what researchers see in the baboon studies.

Reporting in the journal Science, the team trained six Guinea baboons to distinguish real, four-letter English words from non-words. After six weeks, the baboons learned to pick out dozens of words from a group of more than 7,800 non-words.

At the top of the class were Dan, who picked out 308 English words in the group, and Violette, who was able to distinguish 81 real English words from the list.

All of the monkeys in the study performed much better than 50 percent, averaging nearly 75 percent accuracy. Even seeing a word for the first time, the baboons, once trained, were more likely to recognize it as a real word, preferring them over the non-words.

Perhaps most remarkable, the French researchers also found that baboons mistook visually similar non-words for real words in exactly the same pattern that human readers do, said Charles Connor of the Mind-Brain Institute at John Hopkins University in Baltimore, Maryland, who was not involved in the study. “We´re seeing reading-like vision processes can occur in a species without language, and that is really surprising.”

Grainger noted that this study is not suggesting that the baboons are reading; “[they] don´t attach any meaning to the words other than recognizing shapes,” he said. “But the point is they can recognize the right ones, and ones close to the right ones.”

Cognitive psychologist Stanislas Dehaene of the College de France in Paris, said this study was “extraordinarily exciting.”

An expert on the neural basis of reading, Dehaene told Reuters reporter Sharon Begley that the researchers showed for the first time that “we have an animal model of a key component of literacy, the recognition of the visual word form.”

Grainger´s study was less intended as a study of animal intelligence than it was to explore how a brain might learn to read. It suggests that, contrary to popular theories, a brain can take the first steps toward reading without having language skills, especially since baboons don´t.

Results of the study suggest that “the basic biological mechanisms required for reading have deeper evolutionary roots than anyone thought,” said neuroscientist Michael Platt of Duke University, coauthor of an analysis on the study. “That suggests that reading draws on much older neurological mechanisms” and that apes or monkeys are the place to look for them.

Neuroscientists have long been puzzled by reading. Once humans first began doing it in the Middle East about 5,000 years ago, reading spread like wildfire across the ancient world, so fast in fact, that it could not have required genetic changes and entirely new brain circuitry. Those areas do not evolve that fast. Instead, its rapid spread suggests that reading co-opted existing neural structures.

“When we read, we´re capitalizing on object identification, an expertise we already have and one that´s quite ancient,” Grainger said. “We identify a table by its components: its tabletop and four legs. The same goes for identifying words using their component letters.”

The key difference between real words and non-words was the number of frequently recurring bigrams they contained. Bigrams are combinations of two letters, such as ℠it´ and ℠te´ in words such as ℠site´ and ℠kite´. The researchers minimized common bigrams in non-words and maximized them in real words, so that the baboons could discriminate on the basis of statistical dependence between letters.

The baboons revealed they were more likely able to spot words containing the most common bigrams. This correlation shows that they were truly learning and not just memorizing the words.

During the initial testing, baboons were given a reward of dry wheat for every correct response. Once they got the knack, the team decided to take it up a notch.

They showed the baboons strings of four letters that appeared on a screen, but these new strings were never-before-seen by the monkeys. If the baboons decided the letters formed a word, it pressed an oval sign; for non-words — which always contained three consonants and a vowel — it pressed a plus sign.

A short video of the tests, which can be viewed here, shows the baboons swatting the screen with enthusiasm and confidence, much like that of a child acing a video game.

Grainger said the baboons were engaging in “orthographic processing,” which means they are recognizing letters and their positions. While it has nothing to do with sounding out a word, or even understanding it, it is a necessary early step in reading.

Humans use similar cues when reading, said Emmanuel Keuleers, a psychologist at Ghent University in Belgium, who has conducted a similar experiment on humans. Despite their knowledge of English, “our participants partly relied on orthographic stimuli” to discern real words from non-words.

Grainger hopes the results seen in the baboon studies will aid in a clearer understanding of the neural abilities of skilled readers. The study may also help to uncover the causes of reading disabilities such as dyslexia, he added.

Grainger next plans to try to teach baboons an artificial alphabet, which could give greater control over the visual information that defines individual letters, and would provide a more precise idea of how baboons master word recognition.

Among the many surprises revealed in this study, the big one is that it involved baboons rather than their brainier relatives.

“Guinea baboons have a lot of social savvy, since they have to learn about complex male-male and male-female interactions in their troop,” primate curator Craig Demitros of the Brookfield Zoo outside Chicago, told Reuters. “They´re smart, but not at the level of chimps.”

This study, apart from providing a look into the evolution of the brain´s ability to read, also has implications for education. “You might conclude that phonics doesn´t work” as well as teaching children to read by recognizing the entire word, explained Pratt. “This study suggests that reading is all about pattern recognition and not working out phonemes.”

Forward Thinking Of Computer Chips Could Pave Way For Future

Lee Rannals for RedOrbit.com

Researchers at Massachusetts Institute of Technology (MIT) are developing a new kind of computer chip known as Networks-on-Chip (NoC).

Li-Shiuan Peh, an associate professor of electrical engineering and computer science at MIT, and colleagues will be presenting a paper summarizing their research on NoCs in June at the Design Automation Conference.

A typical computer chip today could have six or eight cores, or processing units, that communicate with each other over a single bundle of wires, which is known as a bus.

With a bus, only one pair of cores are able to talk at a time, which could provide a serious limitation in chips with hundreds or thousands of cores.

Peh and her colleagues want to make cores communicate the same way computers that are hooked up to the Internet do by bundling the information they transmit into “packets.”

Each core utilizes its own router, which would be capable of sending a packet down several paths, depending on the condition of the network.

The team was able to establish theoretical limits on the efficiency of packet-switched on-chip communication networks.  They also have measurements performed on a test chip in which they came very close to reaching on several of those limits.

Muticore chips are faster than single-core chips because they are able to split up computational tasks and run them on several cores at once.

Cores that work on the same task sometimes share data, but the core count on commercial chips have been low enough that a single bus is able to handle the extra communication load.

“Networks-on-chip (NoCs) will allow scaling to high core counts (hundreds and even a thousand cores), as existing on-chip interconnects (buses, rings, crossbars) do not scale,” Peh told RedOrbit.

“At a high level, a bus allows one pair of cores to communicate at the same time (low latency, low bandwidth, high power); a ring which connects all cores in a circle in the worst case allows 2 pairs of cores to communicate at the same time (high latency, low bandwidth, low power); a crossbar allows all cores to connect to all other cores at the same time, but at exorbitant area and power (low latency, high bandwidth, high power).”

She said the researchers chip shows that a highly scalable “mesh” on-chip network that connects cores in a grid allows many pairs of cores to communicate simultaneously with a high bandwidth at low power.

“With multi-core power, area and delay budgets much more stringent than old parallel computers, power has to become a first-class power constraint when designing NoCs,” Peh said. “Over the past decade, our group has been researching and designing low-power high-performance NoCs.”

Peh said she started working on NoCs in 1997, while working on her PhD at Stanford with her advisor Prof. William Dally.

“Since then, high-performance multi-core processors in industry has moved from on-chip buses to crossbars (e.g. Sun), rings (e.g. Intel), which are intermediate steps towards a full-fledged on-chip network,” she said.

Peh believes the computer industry will see on-chip networks like meshes in products in five-years.

Luca Carloni, an associate professor of computer science at Columbia University who also researches networks on chip, said advantages of packet-switched networks on a computer chip seems compelling.

He said that those advantage include not only the operation efficiency of the chips themselves, but also “a level of regularity and productivity at design time that is very important.”

He said in a press release that the contributions of Peh are foundational.

Image Courtesy Christine Daniloff/MIT

UCLA’s “Time Machine” To Study Distant Galaxies

[ Watch the Video ]

A team of researchers at the University of California, Los Angeles (UCLA) are building an advanced scientific instrument unlike any other ever built before, with the aim to study some of the oldest galaxies in the universe.

The five-ton spectrometer, known as MOSFIRE (Multi-Object Spectrometer for Infra-Red Exploration), has been installed in the Keck I Telescope at the WM Keck Observatory in Hawaii where, once fully operational, it will receive infrared light that is collected by the telescope. MOSFIRE will then be able to sift through the cosmic dust and see distant objects whose light has been red-shifted as a result of the universe´s ongoing expansion.

Ian McLean, lead researcher on the project, and director of UCLA´s Infrared Laboratory for Astrophysics, said the “time machine” — as it is being dubbed — will allow researchers to study “the most distant, faintest galaxies,” some of which are close to 10 billion years old, being formed just a few billion years after the Big Bang.

“When we look at the most distant galaxies, we see them not as they are now but as they were when the light left them that is just now arriving here,” he added. “We are looking back in time to the era of the formation of some of the very first galaxies, which are small and very faint. That is an era that we need to study if we are going to understand the large-scale structure of the universe.”

With MOSFIRE, it will be much easier to identify even the faintest of galaxies in the universe. The instrument will also enable McLean and his colleagues to attain a more detailed picture of the formation of stars within our own galaxy, the distribution of dark matter across the universe, and merging galaxies, as well as other phenomena.

“We would like to study the environment of those early galaxies,” said McLean. “Sometimes there are large clusters with thousands of galaxies, sometimes small clusters. Often, black holes formed in the centers of galaxies.”

MOSFIRE, a collaborative effort between colleagues from UCLA, the California Institute of Technology and UC Santa Cruz, along with industrial sub-contractors, is the latest in a series of similar projects focusing on deep space analysis. The seven-year, federally-funded, $14 million  initiative got its first hint of life on April 4th, when light from the Keck I Telescope was fed into MOSFIRE for the first time, resulting in an image of two galaxies colliding. The system is expected to be fully operational by September.

MOSFIRE will allow astronomers to study up to 46 galaxies simultaneously, providing the infrared spectrum for each galaxy. Currently, it can take three hours or longer to obtain a good spectrum of just one galaxy, McLean noted.

While construction of the MOSFIRE instrument was undertaken by several colleagues at different locations, the bulk of the mechanical parts were built at UCLA and Caltech. However, the slit unit that enables the team to study 46 galaxies at a time was manufactured in Switzerland. The computer programming was led by UCLA researchers.

MOSFIRE was federally funded by the National Science Foundation (through the Telescope System Instrumentation program), and by Gordon and Betty Moore. Gordon Moore is co-founder, former chairman and chief executive officer, and chairman emeritus of Intel Corp.

“He is a wonderful man with a penetrating intellect,” McLean said of Moore. “We are deeply indebted to him and hope to be able to show him MOSFIRE this.”

MOSFIRE is not McLean´s first project. In the late 1990s he delivered an infrared spectrometer known as NIRSPEC to the Keck Observatory in Hawaii, which housed the world´s largest optical and infrared telescope at the time and which contains what had been the most powerful infrared spectrometer in the world. NIRSPEC is still in use at the Keck Observatory, currently installed on the Keck II Telescope.

The MOSFIRE instrument is approximately five times more sensitive than NIRSPEC and about 100 times more sensitive than McLean´s earliest infrared cameras built in 1986.

Use of the NIRSPEC instrument resulted in severable notable discoveries, including the detection of water on comets, insights into the stars orbiting the enormous black hole at the center of our galaxy, and the discovery of the chemical makeup of brown dwarf stars.

MOSFIRE should far exceed NIRSPEC´s capabilities when it goes fully live in September.

Image Caption: One of the first infrared pictures from MOSFIRE on the Keck I Telescope showing two galaxies in collision: NGC4038 (upper) and NGC4039. Also known as the Antennae galaxies, these objects are about 45 million light years away, in the constellation of Corvus. The exposure was a brief 60 seconds under cloudy conditions. Image credit: Ian S. McLean/W.M. Keck Observatory

Volcanic Plumbing Provides Clues on Eruptions and Earthquakes

Two new studies into the “plumbing systems” that lie under volcanoes could bring scientists closer to understanding plate ruptures and predicting eruptions–both of which are important steps for protecting the public from earthquake and volcanic hazards.

International teams of researchers, including two scientists from the University of Rochester, have been studying the location and behavior of magma chambers on the Earth’s mid-ocean ridge system–a vast chain of volcanoes along which the Earth forms new crust.

They worked in the tropical region of Afar, Ethiopia and the subarctic country of Iceland–the only places where mid-ocean ridges appear above sea level. Volcanic ridges (or “spreading centers”) occur when tectonic plates “rift” or pull apart. This happens when magma (hot molten rock) injects itself into weaknesses in the brittle upper crust, erupting as lava and forming new crust upon cooling.

“These conclusions would not have been possible without the multi-disciplinary expertise of the researchers taking part in these studies,” said Cynthia Ebinger, professor of geophysics at the University of Rochester.

The studies, published in Nature Geoscience, reveal new information about where magma is stored and how it moves through the geological plumbing network.

Magma chambers work like plumbing systems, channeling pressurized magma through networks of underground “pipes.” Finding out where magma chambers lie and how they behave could help identify early warning signs of impending eruptions, according to the researchers.

By analyzing images taken by the European Space Agency satellite Envisat, scientists were able to measure how the ground moved before, during, and after eruptions. Also, Ebinger and Manahloh Belachew, also from the University of Rochester, operated an array of seismographs that provided the depth and detailed time control to gauge the fracturing of the earth and the flow of magma from multiple eruptions in Afar. Using these data, the international team built and tested computer models to find out how rifting occurs.

The team of scientists discovered that the ground started “uplifting” (elevating) four months before the eruption, due to new magma increasing pressure in one of the underground chambers. They hope the ground movement will prove to be precursory signals that are fundamental to predicting eruptions.

In an extensive study of eruptions in Afar and Iceland–two vastly different environments–Ebinger and Belachew found remarkable similarities, with many events occurring within a short space of time. They identified multiple magma chambers positioned horizontally and vertically, allowing magma to shoot in several directions. Earthquake patterns were used to track the migrating magma as it inflated cracks, and to map the rupture of faults above the miles of propagating magma injection zones. The combined data sets show that separate magma chambers fed single eruptions.

A sequence of eruptions in Afar from 2005 to the present is part of an unusual period of volcanic unrest in Ethiopia, and is enabling scientists to learn more about magma plumbing systems at spreading centers. Most spreading centers are about a mile under water at the bottom of the ocean, making detailed observations extremely challenging.

“Our studies in Ethiopia open the door to new discoveries of multi-tiered magma chambers along submerged mid-ocean ridges worldwide,” said Ebinger. “We also found that magma movement and faulting during intense episodes create much of the characteristic rift valley topography, where narrow lowlands are found between mountain ranges.”

When magma intrudes into a region it generates earthquakes, according to Belachew, a Ph.D. candidate. “The detailed relations of the earthquake sequences in both time and space allow us to track the movement of magma and associated fault rupture with unprecedented detail,” he said.

Tim Wright, from the University of Leeds’ School of Earth and Environment, heads the international Afar Rift Consortium. “The dramatic events we have been witnessing in Afar in the past six years are transforming our understanding of how the crust grows when tectonic plates pull apart,” said Wright. “Our work in one of the hottest places on Earth is having a direct impact on our understanding of eruptions from the frozen volcanoes of Iceland.”

The studies were funded by the UK Natural Environment Research Council through the Afar Rift Consortium, the National Centre for Earth Observation, the US National Science Foundation, the UK Royal Society, and the Icelandic Research Fund. Seismic instrumentation was provided by IRIS-PASSCAL and Seis-UK; GPS instrumentation by UNAVCO.

Image Caption: Sheets of molten rock, called dikes, rise through the earth’s crust. The question marks indicate uncertainty of the shape of the channels that feed the dikes. Illustration Credit: Cynthia Ebinger/University of Rochester

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Ancient Cave Bacteria Could Produce Better Drugs

Caves in New Mexico offer their visitors breath-taking views, lessons about Earth´s history, and plenty of jealousy-inducing photographs. But now team of microbiologists who recently visited the Lechuguilla cave systems found an even better souvenir to take home: Ancient bacteria with the power to fight off modern antibiotic drugs.

1,600 feet below the surface of the Earth, these bacteria lined the walls of the Lechuguilla cave, yet to be touched or discovered by humans or their drugs.

These bacteria, while resistant to antibiotics, aren´t infectious to humans. Their benefit to us, however, will be in their study. As these bacteria are able to resist new synthetic drugs, scientists will be able to study how bacteria withstand such medications, thereby creating better, more potent drugs.

Speaking with National Geographic reporter Dave Mosher, study leader and chemical biologist at McMaster University in Ontario said, “Clinical microbiologists have been perplexed for the longest time. When you bring a new antibiotic into the hospital, resistance inevitably appears shortly thereafter, within months to years.”

“It´s still a big question: Where is this coming from?” Wright said. “Almost no one thought to look at other bacteria, the ones that don´t necessarily cause disease.”

The US National Park Service has severely limited access to this pristine and untouched site, but has agreed to let geomicrobiologist Hazel Barton of Northern Kentucky University  and her team sample the microbial life within.

Wright says the area is so pristine you can still see the tracks of everyone who has ever entered the cave.

Scraping off samples of thick mats of bacteria called biofilm from the cave walls, Barton then delivered her samples to Wright´s lab. There, his team spent three years analyzing the bacteria, looking for antibiotic resistance.

Disease-causing bacteria have often become resistant to antibiotics, usually quite quickly. These bacteria, called superbugs, can block, immobilize and even destroy natural and synthetic antibiotics. Such superbugs are usually found in hospitals where antibiotics are used frequently. These antibiotic-rich environments force the bacteria to react and adapt rapidly.

This isn´t Wright´s first time to look for ancient bacteria in untouched locales. Previously, Wright had found bacteria in ancient soils and permafrost, according to Julian Davies of the University of British Columbia. Davies was not involved in the study.

As Wright was able to grow 500 different kinds of bacteria from the cave walls, though only 93 kinds grew in a medium that allowed for testing of antibiotic resistance. Of these 93, 70 were able to resist 3 out of 4 different antibiotics.

“This tells us antibiotic resistance genes are very old, but what it doesn´t tell us is how they find their way into the hospital,” Davies said.

“I honestly didn´t expect to see the sheer diversity of genes fighting all of these different antimicrobial compounds,” said Wright.

Davies questions whether or not the bacteria were able to resist the antibiotics because they were grown in a lab or if they are naturally able to resist since they are so old.

As further testing is being conducted to determine any natural antibiotics in the cave, Wright says clinicians and pharmaceutical companies should be alert, should new developments arise.

image Caption: A researcher looking at gypsum flowers in ‘Lebarge Borehole.’ Credit: (c) Max Wisshak/speleo-foto.de

Exercise And Attitude May Be Thermostat For Hot Flashes

Attitude may play an important role in how exercise affects menopausal women, according to Penn State researchers, who identified two types of women — one experiences more hot flashes after physical activity, while the other experiences fewer.

“The most consistent factor that seemed to differentiate the two groups was perceived control over hot flashes,” said Steriani Elavsky, assistant professor of kinesiology. “These women have ways of dealing with (hot flashes) and they believe they can control or cope with them in an effective way on a daily basis.”

Women who experienced fewer hot flashes the day after participating in vigorous to moderate physical activity were more likely to be part of the group that felt they had control over their hot flashes. Women who had more hot flashes following exercise were likely to be those who felt they had very few ways of coping with their hot flashes, Elavsky and her colleagues report in a recent issue of Maturitas.

Elavsky suggested that cognitive behavioral therapy may help some women feel they have more control over their bodies and reactions to hot flashes.

The participants with fewer hot flashes the day after vigorous exercising were also less likely to experience anxiety and depression. However, women who had fewer hot flashes the day after only light or moderate physical activity had higher levels of pessimism and depression than others.

“The bottom line for research is that people need to look at individual differences,” said Elavsky. “It’s not enough anymore to do a study and look at overall impact of an exercise program on symptoms. It’s very clear that we need to look at the different responses that women might have, and try to understand these individual differences more.”

Elavsky and her colleagues followed 24 menopausal women for the length of one menstrual cycle, or for 30 days if they were no longer menstruating. Each woman used a personal digital assistant to record hot flashes and wore an accelerometer at the hip to track physical activity. The women in the study regularly had hot flashes before the start of the study, experiencing from five to 20 a day.

“The real-time reporting of symptoms and the objective measurement is a strength of the study,” said Elavsky. “There aren’t any studies out there that use both of these approaches. “¦ To ask a woman to report a symptom when she’s experiencing it is the most valid assessment.”

At the beginning of the study, the participants completed evaluations that looked at their depressive symptoms, chronic stress, perceived control over hot flashes, and personality. They had a physical exam where researchers measured levels of reproductive hormones and body composition. Each woman served as her own control, therefore the data was analyzed for each separately.

If a woman experienced a hot flash during the observation period, she entered the event on the PDA, along with the severity and length of the event, where she was, if she had recently consumed a trigger, such as coffee, and included other situational information. At four random times throughout the day, the PDA prompted the woman to assess and record daily stressors and mood. At the end of the day, each completed a fifth assessment and looked retrospectively at how her day went and how well she coped with her hot flashes that day.

“I was surprised by how large the individual differences were,” said Elavsky. “I was also surprised that the association was present in terms of statistically significant association only in a handful of women — and among those, there were two whose physical activity led to more hot flashes the next day and one that had the opposite. Maybe the reason why we don’t see the associations in larger studies is because they cancel each other out.”

Also working on this research were Peter C. M. Molenaar, professor of human development; Carol H. Gold, research associate for the Center of Healthy Aging; Nancy I. Williams, professor of kinesiology and physiology; and Keith R. Aronson, associate director of the Children, Youth and Families Consortium, all at Penn State.

The National Institute of Child Health and Human Development supported this research.

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Highly Advanced Killer Dinosaurs On Other Planets?

What was old is once new again, as a new study discusses the possibility of advanced, cunning, and intelligent dinosaur-like creatures living on other planets in our universe. To add to the frightening image, the study simply concludes with the thought, “We would be better off not meeting them.”

This research appears in the Journal of the American Chemical Society.

Scientist Ronald Breslow, Ph. D., author of the report, discusses an old and puzzling mystery of why the core and foundations of amino acids, sugars, and the genetic materials DNA and RNA have only one orientation or shape.

These genetic materials have only two possible ways in which they are oriented, left or right, mirroring one another, resembling a pair of hands. This orientation is known as Chirality. In order for life to form from this genetic material, proteins, for example, must have only one chiral form of the amino acids, either left-facing or right-facing. With few bacterial exceptions, all the amino acids in all the life on earth have a left-handed orientation. Sugars, on the other hand, will most often have a right-handed orientation. Breslow says the reason there is such a dominance of one orientation can be found in the first amino acids to arrive at Earth, carried by meteorites all those billions of years ago. According to Breslow, these amino acids set a pattern for an L-geometry, leading to the D-shaped sugars found in DNA.

So how does one draw the line of conclusion between L-shaped acids and D-shaped sugars and advanced, cunning, and intelligent super dinosaurs?

Even Breslow says there´s no way to know for sure if these proteins could produce such a creature, but suggests if these alien monsters had the good fortune not to be wiped out by a massive meteor as Earth´s dinosaurs were, then by now they´d be quite advanced.

According to his research, Dr. Breslow says, “Of course, showing that it could have happened this way is not the same as showing that it did.” He adds: “An implication from this work is that elsewhere in the universe there could be life forms based on D-amino acids and L-sugars. Such life forms could well be advanced versions of dinosaurs, if mammals did not have the good fortune to have the dinosaurs wiped out by an asteroidal collision, as on Earth. We would be better off not meeting them.”

If this logical jump from backwards genetic orientation to super advanced dinosaurs seems like a bit of a stretch, you aren´t alone.

“None of this has anything to do with dinosaurs,” writes Brian Switek in Dinosaur Tracking, a blog for Smithsonian.com.

Switek mentions the earliest dinosaurs on earth didn´t originate until 230 million years ago, out of the time frame of 4 billion suggested by Breslow. Furthermore, Switek says the dinosaurs were only allowed to grow and evolve on this planet because the ruling species at the time (Triassic dinosaurs, who Switek describes as small, rare, and marginal) were wiped out due to mass extinction. Only then did what we know as “dinosaurs” today come to be. Breslow´s assumption these creatures would have the same story as Earth´s dinosaurs and evolve in the same way is a bit generous.

Switek also points out the genetic legacy of dinosaurs exists even today. Birds are from the lineage of dinosaurs, and some species of birds are even quite intelligent. In conclusion, Switek writes: “A simple shift in our understanding of dinosaur evolution has rescued the beloved creatures from extinction. I deeply doubt that there are dinosaurs in space, but I am glad that at least one variety of feathered dinosaur remains with us here.”

New Birth Control Labels Detail Increased Risk For Blood Clots

The US Food and Drug Administration (FDA) has begun to add information to labels of popular birth control medications to warn about the increased risk of blood clots.

Bayer AG´s “Yaz” or Yasmin is one of the medications receiving the new label, though all common types of birth control pills increase a woman´s risk of potentially fatal blood clots.

The FDA is following up new studies with these labels, saying certain forms of birth control like Yaz show an even higher increase for blood clots. Yaz contains a synthetic hormone known as drospirenone which has been shown to increase the potential for blood clots.

In a statement, the FDA said, “The revised drug labels will report that some epidemiological studies reported as high as a three-fold increase in the risk of blood clots for drospirenone-containing products “¦ whereas other epidemiological studies found no additional risk.”

In their own study, the FDA found 10 in every 10,000 taking pills with drospirenone would get one blood clot per year, compared to only 6 in 10,000 women. These blood clots become fatal if they break loose and travel up to the brain, heart, or lungs.

Despite these risks, women may still be on the safe side by taking the pills; The FDA noted women who become pregnant are even more likely to get these blood clots.

This announcement follows a decision made in December to revise the labels of pills containing drospirenone. An advisory committee of experts to the FDA made the decision in order to give clearer information about these pills. Some of the tests, however, did not conclusively show an increase of blood clots in women taking these pills. Therefore, these experts stopped short of declaring the risks of taking these pills outweighed their benefits.

A change in the label is a good step forward for some, though others are saying this action isn´t enough to fully protect women.

During the December meeting to determine these new labels, some women´s advocacy groups called for the pills to be taken off the market. To make their point, these advocacy groups, along with patients told stories of sudden-deaths or life changing disabilities experienced by themselves of loved ones who were taking Yaz or Yasmin.

Yaz is a reformulated version of Yasmin, and is one of America´s top selling contraceptive medications. Owner Bayer sold $374 million worth of Yaz in 2010, according to data from IMS Health. The recent introduction of generics have cut into sales of Yaz, however.

Executive director of the National Women´s Health Network, Cynthia Pearson, testified at the December meeting, saying simply changing the label will not protect women from these blood clots.

“I fear that if the FDA holds another public hearing three years from now, there will be a new group of women telling sad stories about the harm done to their health by clots,” she told the Chicago Tribune.

Women who take any type of birth control medication have an increased risk of blood clots, particularly as they get older.

US Health authorities have ordered the labels of some types of birth control to be revised, including Bayer´s “Yaz”. The revised labels are to advise users of a higher risk of blood clots.

A new label for Yaz has already appeared on the FDA website, and says, “Women who use birth control pills with drospirenone (like Yaz) may have a higher risk of getting a blood clot.

Some studies reported that the risk of blood clots was higher for women who use birth control pills that contain drospirenone than for women who use birth control pills that do not contain drospirenone.”

The FDA did mention, however, there were mixed results in these studies.

In a statement, the FDA said, “The studies reviewed did not provide consistent estimates of the comparative risk of blood clots between birth control pills that contain drospirenone and those that do not.”

“The studies also did not account for important patient characteristics (known and unknown) that may influence prescribing and that likely affect the risk of blood clots,” it added.

NASA Expert Speaks On Coal-fired Power Plants, Climate Change

Lawrence LeBlond for Redorbit.com

A leading climate change scientist at NASA is urging the United Kingdom to cease building coal-fired power plants, and is calling for a worldwide tax on all carbon emissions, to tackle the climate change fight head-on, reports BBC Scotland.

Dr. James Hansen said, in an interview with BBC Scotland, that averting the worst consequences of human-induced climate change is a “great moral issue” on par with slavery, and added that storing up expensive and destructive consequences for the future of society is an “injustice of one generation to others.”

“In the case of civil rights the courts were able to come to the assistance of people whose civil rights were being violated by requiring governments to say what they were going to do about for example, segregated schools. In the same way, governments could be required to present a plan to reduce carbon emissions to ensure young people have a decent future,” said Hansen.

Hansen, 71, has been awarded the prestigious Edinburgh Medal at the city´s Science Festival for his contribution to science. He plans to use his acceptance speech to call for a carbon emissions tax to save the climate.

Hansen has argued that the worldwide publicity given to the referendum on Scottish independence was the ideal time for First Minister Alex Salmond to be “honest” about his long-term climate change policies.

Hansen told daily newspaper The Scotsman that US President Barack Obama failed to highlight global energy issues by targeting domestic policy, and urged Salmond not to do the same.

“Obama had the chance to say, ℠OK we´re going to fight our fossil fuel addiction´ and take on the big corporations, but instead he concentrated on health,” Hansen, director of NASA´s Goddard Institute for Space Studies, told the paper.

“Salmond should use this time and be very, very open and honest about the energy plans are for the long run and the need to move towards the post-fossil fuel era,” Hansen urged. “You might think Scotland is going to be like Norway. But that does not prevent moving towards a carbon-free economy.”

Scotland has plans for two coal-fired power facilities to be built at Grangemouth and Hunterston in Ayrshire. But Hansen believes the country would be better off building new nuclear and renewable energy facilities to prevent further climate changes.

“For base load electric power, I think that we need next generation nuclear power, which can be much safer and which can burn nuclear waste and solve that major problem with nuclear power,” he said.

US firm, Summit Power Group, is spearheading the plan to build the coal-fueled power plant at the port of Grangemouth. It said the plant would use carbon capture and storage (CCS) technology in a bid to reduce emissions by more than 90 percent.

A public inquiry is due to be carried out before the Scottish government makes a final decision on proposals for a similar facility at Hunterston. In November last year North Ayrshire Council rejected plans by Ayrshire Power for a coal-fired station but the company vowed to fight on.

Hansen, who has been arrested four times for protesting against projects he believed to be damaging to the environment, is standing strong with his opposition to coal-fired power plants in Scotland, and is ready to call for a global tax on carbon emissions, to prevent further climate change.

While acknowledging that oil and gas would be around for years to come, he said that did not preclude plans which that see money from carbon tax distributed to the public. “Using easily available oil and gas which can be traded on the international market is something that is going to happen, but we have to phase it out,” he told The Scotsman.

“We could have a gradually rising tax on carbon emissions, with the money collected from companies distributed to the public in a monthly dividend, to pay less for their fuel bills and start thinking of lifestyle changes, such a carbon-efficient car or building a home which includes energy efficient features,” he added.

“Why haven´t we done something like that before? Because fossil fuel industries have too much clout. Money talks in capitals around the world,” he said.

In an interview with The Guardian, Hansen said the latest climate models show the planet is on the brink of an emergency. Humanity is facing the threat of repeated natural disasters from extreme weather events that could affect large areas of the planet.

“The situation we´re creating for young people and future generations is that we´re handing them a climate system which is potentially out of their control,” he said. “Our parents didn´t know that they were causing a problem for future generations but we can only pretend we don´t know because the science is now crystal clear,” he said.

“We understand the carbon cycle: the CO2 we put in the air will stay in surface reservoirs and won´t go back into the solid earth for millennia. What the Earth´s history tells us is that there´s a limit on how much we can put in the air without guaranteeing disastrous consequences for future generations. We cannot pretend that we did not know,” he added.

Hansen said his proposal for a global carbon tax is based on the latest analysis of CO2 levels in the atmosphere and the impact that has on global temperatures and weather patterns.

His scientific paper on the issue, which is co-authored by 17 of his peers, including climate scientists, biologists and economists, calls for an immediate 6 percent annual cut in CO2 emissions, and a substantial growth in global forest cover to avoid catastrophic climate change by the end of this century.

The paper, which is in the final stages of publication by the US journal Proceedings of the National Academy of Sciences (PNAS), says that a global tax on fossil fuels is the strongest tool for forcing energy firms and consumers to switch quickly to zero carbon and renewable energy sources.

In his plan, the carbon tax would increase year on year, with the tax income paid back to the public as a dividend, shared equally, rather than put into government coffers. Because the tax would greatly increase the cost of fossil fuel energy, consumers that rely on green or low carbon sources of power would benefit the most as this dividend would come on top of cheaper fuel bills. It would promote a dramatic increase in the investment and development of low-carbon energy sources and technologies.

The proposal would also require those who are the most wasteful energy users — people with several homes, private jets, and fuel-hungry vehicles — to dramatically change their energy use habits. Hansen and his colleagues warn that failing to cut CO2 emissions by 6 percent now will mean annual cuts would need to reach a more drastic 15 percent per year by 2022.

Hansen said current attempts to limit carbon emissions have been “completely ineffectual.” Under a global tax proposal, the mechanisms for controlling fossil fuel use would be taken out of the hands of individual states influenced by energy companies, and politicians anxious about winning elections.

“It can´t be fixed by individual specific changes; it has to be an across-the-board rising fee on carbon emissions,” Hansen told The Guardian. “We can´t simply say that there´s a climate problem, and leave it to the politicians. They´re so clearly under the influence of the fossil fuel industry that they´re coming up with cockamamie solutions which aren´t solutions. That is the bottom line.”

Hansen, regarded as one of the most influential figures in climate science, is the creator of one of the first global climate models, and his work in pioneering warnings about global warming is frequently cited by climate campaigners such as former US vice president Al Gore.

He will be appearing at the 2012 Edinburgh International Science Festival tonight in the “Our Climate Future” discussion at 8 p.m. local time, and then again tomorrow in “Fixing The Planet” at 5:30 p.m., both being held at the National Museum of Scotland.

More information can be obtained at www.sciencefestival.co.uk

Hansen´s climate change stance is, in part, the subject of debate by a group of 49 former NASA scientists and astronauts who sent a letter to NASA Administrator Charles Bolden last week, criticizing the agency for its role in advocating a high degree of certainty that human-made CO2 is a major cause of climate change while neglecting practical evidence that calls the theory into question.

The group, which includes seven Apollo astronauts and two former directors of NASA´s Johnson Space Center, indicated in the letter that they were disappointed over the failure of NASA and the Goddard Institute for Space Studies (GISS) to make an objective assessment of all available scientific data on climate change. They believe that NASA is relying too heavily on complex climate models that have proven scientifically inadequate in predicting climate change only one or two decades in advance.

H. Leighton Steward, chairman of the non-profit Plants Need CO2, said many of the former NASA scientists have doubts about the significance of the CO2 climate change theory and have concerns over NASA´s advocacy on the topic. While making presentations in late 2011 to many of the signatories of the letter, Steward realized that the NASA scientists should make their concerns known to NASA and the GISS.

“These American heroes — the astronauts that took to space and the scientists and engineers that put them there — are simply stating their concern over NASA´s unusual advocacy for an unproven theory,” said Steward. “There´s a concern that if it turns out that CO2 is not a major cause of climate change, NASA will have put the reputation of NASA, NASA´s current and former employees, and even the very reputation of science itself at risk of public ridicule and distrust.”

Why Do Hospitals Carry Fast Food In Their Cafeterias?

Corporate Accountability International, an advocacy group that challenges corporate abuse and fights for corporate accountability to public interests, is leading a larger campaign to persuade McDonald´s and other fast food outlets from marketing unhealthy food to kids.

Specifically, the group is seeking the removal of such chains from operating inside of hospitals, many of which operate next to hospital cafeterias. That effort has been endorsed by nearly 2,000 health professionals, some of which work at the very hospitals still housing the fast food giant, says campaign director Sara Deon.

“Dear Hospital Administrator,” Deon´s open letter to hospital administrators begins, “On behalf of thousands of health professionals who work daily to improve public health and who have joined the Value [the] Meal campaign, we are calling on you to help curb the epidemic of diet-related disease and to stop fostering a food environment that promotes harm, not health.”

“We urge you to end your contract with McDonald´s and to take action to remove the McDonald´s restaurant from your hospital.

Doctors at prestigious Cleveland Clinic tried to oust McDonald´s in 2005, however it is still there, even though one of the doctors who led the effort is now the hospital´s CEO. In many cases, long-term contracts keep unwelcome food vendors in place.

McDonald´s claims a remaining 27 outlets in hospitals that offer balanced choices, “Today, we offer more variety than ever in our menu and we trust that our customers will make the appropriate choices for them, their families and lifestyles.”

Deon continues in her letter to call out McDonald´s, “It´s really no surprise McDonald´s sites stores in hospitals. After all, for decades, McDonald´s has attempted to co-opt the health community, to deflect blame for the epidemic of disease that it has helped drive, and to pose itself as part of the solution.”

“Yet, as a key decision maker at your hospital, you understand the need for cultivating healthier communities and better food environments. Our children, the medical community, and our health care system will benefit from your leadership on this issue.”

The country´s largest seller of hamburgers isn´t the only seller of fatty, salty or sugary in care facilities. Pizza Hut, Subway, Chick-fil-A, Starbucks and other chains have in-hospital outlets.

A review by the vegan advocacy group Physicians Committee for Responsible Medicine found several hospitals that gave space to multiple fast food outlets and also had staff cooks serving such dishes as fried chicken and country-fried steaks in their own cafeterias.

Deon admits her group is picking on McDonald´s because it is big: “They profit most and they lead the way.” However she does not let hospital administrators off lightly.

“Every day, parents, children, and health professionals turn to your institution for advice on well-being, for support in preventing and treating illness, and for sustaining a healthy community,” Deon continues.

“As a hospital, you serve as a local authority on health, and as such, the community you serve looks to you and to your environment as a guide for their well-being.”

FDA Asks Appeals Court To Overturn Graphic Cigarette Labels

Brett Smith for RedOrbit.com

“It doesn’t matter how big the warnings on the cigarettes are; you could have a black pack, with a skull and crossbones on the front, called TUMORS, and smokers would be around the block going, ℠I can’t wait to get my hands on these“¦ things! I bet ya get a tumor as soon as you light up!´”

In a move that appears to be straight out of Dennis Leary´s famous stand-up comedy movie “No Cure for Cancer,” the FDA challenged a U.S. District Court ruling that banned the mandating of graphic images on all cigarette packaging on Tuesday.

The administration disputes the 19-page March ruling by U.S. District Court Judge Richard Leon that said the requirement would “violate the First Amendment by unconstitutionally compelling speech” for companies and could set a dangerous precedent.

At Tuesday’s U.S District Court of Appeals hearing, FDA lawyer Mark Stern explained to the court that the graphic labels were necessary because they made a direct and immediate connection to the possible consequences of smoking cigarettes, especially for young smokers.

“Adolescents notoriously underestimate their ability to resist addiction,” he said.

“Do (the images) accurately and realistically depict the message that this is really addictive? Yes.”

Judge Janice Rogers Brown, asked if the government could mandate aggressive cigarette packaging that included messages like, “Stop! If you buy this product, you are a moron,” or “Smokers are idiots.”

“No, I don’t think saying ℠smokers are idiots´ is accurate,” Stern replied. He said such a warning would be “problematic.”

Judge A. Raymond Randolph, wondered aloud if the same policy could be extended to other businesses like those in the automobile industry that could be compelled to include graphic car crash images and phrases like “speed kills.”

Lawyers for tobacco companies fighting against the mandated packaging made similar arguments. To make their case, they superimposed the graphic FDA images over a McDonald´s bag with warnings that that company´s food causes heart disease. They also made similar packaging that linked alcohol to birth defects and Hersey´s chocolate to tooth decay.
Stern said some of those comparisons trivialized the important issue of nicotine addiction, which cannot be equated to eating candy or fast food.

Arguments took a political bent as the only judge appointed by a Democrat, Judith W. Rogers, did not question Obama administration officials, but instead focused on tobacco company lawyer Noel J. Francisco, who argued that the government was going beyond mere facts with the campaign and forcing tobacco companies to advocate against their own products.

“You don’t have to be Sherlock Holmes … to figure out what the government is doing here: telling people, ‘Quit smoking now,'” he said.

In 2009, Congress passed a law that gave the FDA sweeping powers with respect to regulating the tobacco industry, its packaging, and its advertising. This was followed by nine new warning labels issued by the administration in June 2011 that would go into effect in September. The debut of these labels would change cigarette packaging for the first time in 25 years.

Many expect any ruling by the appellate court to be challenged, with the possibility of the case eventually reaching the Supreme Court.

HP Goes After Amazon With New Cloud Services

Hewlett-Packard launched a new portfolio of cloud services on Tuesday, dubbed HP Converged Cloud, which could boost sales of its servers and software to large corporate customers.

Cloud computing offers a more efficient use of information technology resources by allowing businesses to access large amounts of stored data and computational power via the Internet.

“There is a new wave of cloud and mobile computing, and big data, and there is a gap between what businesses need and what information technology is delivering,” Bill Veghte, chief strategy officer and executive vice president, Software, HP, told Quentin Hardy of the New York Times.

“HP Converged Cloud enables enterprises to incorporate a blend of public, private and managed cloud services with their existing IT to create a seamless hybrid environment that rapidly adapts to their changing requirements.”

HP, which has had four chief executives over the past seven years, has been steadily losing market share to rivals like Amazon, which is thought have one of the largest corporate cloud businesses, and IBM.

However, Amazon only sells access to computing and data storage, not hardware.  And while IBM is a major player in computers, HP´s data storage systems are regarded as particularly strong.  The company´s large-scale automation software is also seen as an underutilized strength.

With Converged Cloud, HP will offer businesses the ability to build their own clouds, or to access public clouds, including a system HP is expected to bring online in a few weeks.

“The offering provides on-demand compute instances or virtual machines, scalable online storage capacity and accelerated delivery of cached content to end users,” HP said.

“As a result, developers are able to deploy services within minutes and pay only for the resources they use.”

“Also on May 10, HP Cloud Services will introduce, as a private beta, two additional Infrastructure-as-a-Service offerings: a relational database service for MySQL, and a block storage service that supports movement of data from one compute instance to another.”

Other services in the new portfolio include:

– Cloud Maps, which provides prepackaged application templates that create a customized catalog of application services.

– HP Service Virtualization 2.0, which allows clients to test the quality and performance of cloud or mobile applications without disrupting production systems.

– HP Virtual Application Networks, which speeds application deployment, automates management and ensures network service levels.

The company also launched two new networking services — HP Virtual Network Protection Service and HP Network Cloud Optimization Service — that will improve network security and cloud-based service delivery.

Roughly half of HP´s $130 billion in annual revenue comes from large companies, which tend to wade slowly into new technology.   The company will likely leverage its relationships with large enterprise customers to sell its Converged Cloud services, which emphasize operational flexibility, management control and security rather than cutting-edge technology.

Additional information about HP´s cloud services can be viewed at www.hp.com/go/convergedcloud2012.

‘Nontoxic’ Nail Polish Contains Toxins, Report Finds

A Department of Toxic Substances Control (DTSC) report found in California salons that “nontoxic” nail polishes actually have high levels of agents linked to birth defects.

The report released on Tuesday found that the mislabeled nail products have the potential to harm thousands of workers in over 48,000 nail salons in California, and their customers.

Agency officials said the false claims may be a violation of a state law that requires disclosure of harmful chemicals in consumer products.

A final decision on whether the companies will be facing legal action will be made by the state attorney general.

Investigators randomly chose 25 brands of polishes that are available only at nail salons during the research, including a number of products claiming they were free of the chemicals toluene, dibutyl phthalate (DBP) and formaldehyde.

The regulators said exposure to large amounts of these chemicals has been linked to development problems, asthma and other illnesses.

The investigators found that 10 out of 12 products that claimed to be free of toluene actually contained it, and four of the products had high levels of the toxin.

According to the report, five of seven products that claimed to not have the toxins actually included one or more in significant levels.

“We know there are exposures at salons, both to workers and customers, and we’re concerned about potential harm,” Karl Palmer, the DTSC’s pollution prevention performance manager who oversaw the report, told The Associated Press (AP). “Our strategy first and foremost is to shed light on the reality of what’s in these products and put this information out to everyone.”

The agency said all three of the chemicals are linked to chronic health conditions when inhaled, and that the 121,000 licensed nail care technicians who work in the salons are the most at risk.

“We are alarmed by the results of this report,” Julia Liou, co-founder of the California Healthy Nail Salon Collaborative and a public health administrator for Asian Health Services, said in a statement to AP and the Los Angeles Times. “The misbranding of products is not only a major public health problem, but also interferes with a salon worker’s right to a safe and healthy work environment.”

Last year, Boston health officials approved regulations requiring salons to get health permits and establish more protections for workers.  San Francisco will start to formally recognize salons that use toxic-free products as well.

Liou, co-founder of the collaborative and public health administrator at Asian Health Services in Oakland, said the new state report is alarming and could undermine the efforts of owners trying to do the right thing to protect their workers.

“This is a major public health issue and it really interferes with workers’ right to a healthy work environment,” she told the LA Times. “Workers shouldn’t have to suffer health impacts because a manufacturer is making false claims.”

Hue Nguyen, 58, has worked as a manicurist in the Bay Area since 2004, according to a report by the LA Times, and she said after she started working at the salon, she started feeling dizzy and getting headaches.

“I think it is related to the chemicals,” she told the LA Times through a translator, claiming that she was healthy until she began the job.

Nail companies claim health officials should focus on ventilation and protective gear rather than products.

Doug Schoon, scientist and co-chairman of the Nail Manufacturers Council told the LA Times that instead of throwing out the chemicals, people should be better informed on how to use them “in a safe fashion.”

Phuoc Dam, a manager of a nail salon in Brea, said he tries to buy toxic-free nail polish and ensure his workers have fresh air.

However, he told the LA Times that he still worries about the long-term effects of nail products on his staff, including his wife, which is one of the salon’s manicurists.  He said that his wife has recurring headaches and dizziness.

One legal expert on environmental law told AP that if the state attorney general decides to act on the report, and nail polish makers are unsuccessful at fighting it, then “the retailers and manufacturers of these products may be subject to litigation and liability exposure,” Thomas J.P. Henry said.

Summer Temperature Variability May Increase Mortality Risk For Elderly With Chronic Disease

Large day-to-day variations in temperature could result in thousands more deaths per year

New research from Harvard School of Public Health (HSPH) suggests that seemingly small changes in summer temperature swings–as little as 1°C more than usual–may shorten life expectancy for elderly people with chronic medical conditions, and could result in thousands of additional deaths each year. While previous studies have focused on the short-term effects of heat waves, this is the first study to examine the longer-term effects of climate change on life expectancy.

“The effect of temperature patterns on long-term mortality has not been clear to this point. We found that, independent of heat waves, high day to day variability in summer temperatures shortens life expectancy,” said Antonella Zanobetti, senior research scientist in the Department of Environmental Health at HSPH and lead author of the study. “This variability can be harmful for susceptible people.”

In recent years, scientists have predicted that climate change will not only increase overall world temperatures but will also increase summer temperature variability, particularly in mid-latitude regions such as the mid-Atlantic states of the U.S. and sections of countries such as France, Spain, and Italy. These more volatile temperature swings could pose a major public health problem, the authors note.

Previous studies have confirmed the association between heat waves and higher death rates. But this new research goes a step further. Although heat waves can kill in the short term, the authors say, even minor temperature variations caused by climate change may also increase death rates over time among elderly people with diabetes, heart failure, chronic lung disease, or those who have survived a previous heart attack.

The researchers used Medicare data from 1985 to 2006 to follow the long-term health of 3.7 million chronically ill people over age 65 living in 135 U.S. cities. They evaluated whether mortality among these people was related to variability in summer temperature, allowing for other things that might influence the comparison, such as individual risk factors, winter temperature variance, and ozone levels. They compiled results for individual cities, then pooled the results.

They found that, within each city, years when the summer temperature swings were larger had higher death rates than years with smaller swings. Each 1°C increase in summer temperature variability increased the death rate for elderly with chronic conditions between 2.8% and 4.0%, depending on the condition. Mortality risk increased 4.0% for those with diabetes; 3.8% for those who’d had a previous heart attack; 3.7% for those with chronic lung disease; and 2.8% for those with heart failure. Based on these increases in mortality risk, the researchers estimate that greater summer temperature variability in the U.S. could result in more than 10,000 additional deaths per year.

In addition, the researchers found the mortality risk was 1% to 2% greater for those living in poverty and for African Americans. The risk was 1% to 2% lower for people living in cities with more green space.

Mortality risk was higher in hotter regions, the researchers found. Noting that physiological studies suggest that the elderly and those with chronic conditions have a harder time than others adjusting to extreme heat, they say it’s likely these groups may also be less resilient than others to bigger-than-usual temperature swings.

“People adapt to the usual temperature in their city. That is why we don’t expect higher mortality rates in Miami than in Minneapolis, despite the higher temperatures,” said Joel Schwartz, professor of environmental epidemiology at HSPH and senior author of the paper. “But people do not adapt as well to increased fluctuations around the usual temperature. That finding, combined with the increasing age of the population, the increasing prevalence of chronic conditions such as diabetes, and possible increases in temperature fluctuations due to climate change, means that this public health problem is likely to grow in importance in the future.”

On the Net:

New Research Depicts Precisely How Sand Flows

Lee Rannals for RedOrbit.com

New research from the Massachusetts Institute of Technology (MIT) may have an impact in a range of industries, from engineering to pharmaceutical manufacturing.

Ken Kamrin of MIT’s Department of Mechanical Engineering has created a model that predicts the flow of granular materials under a variety of conditions.

Sand’s behavior, which is part fluid, part solid, has made it difficult for researchers to predict how it and other granular materials flow under various conditions.

Having a better model of how sand flows could help optimize processes like pharmaceutical manufacturing and grain production.

When making pills, grains pour through industrial chutes and silos in great quantities, which can lead to blockages that can be costly and dangerous.

Now, Kamrin’s model is able to make predictions of where grains will flow, whether through chutes or in a circular trough, in a near-perfect match with actual results.

“This kind of versatility could enhance the modeling of soil and debris transport phenomena from rapid landslides all the way down to steady long-term soil creep, or intermediate cases where rapid and slow zones might occur simultaneously in different locations,” Kamrin told RedOrbit.

Ken said his “Eureka!” moment during the research was the realization that a simple nonlocal framework presented for flowing emulsions actually has the necessary form that allow scientists to see “several tricky phenomena that had been observed in granular flows.”

“The fact that emulsions and grains might behave similarly is intriguing but not that unexpected since they share some key microstructural similarities,” he said.

According to Kamrin, they are both amorphous, and are composed mostly of randomly packed objects.

He said one of the major contributions of this model was a nonlocal framework.  This type of model becomes more and more important as the flow rate slows down, according to Kamrin.

“The nonlocal picture describes how the motion of a grain can be directly influenced by nearby grain movements rather than the local stresses alone, which could improve the modeling of various granular-geological phenomena especially on geological time-scales,” he told RedOrbit.

Ken modified equations for existing continuum models to factor in grain size, and then tested his model on several configurations.

The new model not only predicted areas of fast-flowing grains, but was also able to predict where grains would be slow moving, at the very edges of each configuration.

The new model’s predictions matched closely with particle-by-particle simulations in the same configurations.

He said engineers could test shapes of chutes and troughs in the model to help them find geometry that maximizes flow, or mitigates dangerous wall pressure, before designing or building equipment to process granular materials.

His model could help geologists understand landslides and avalanches, and help engineers come up with new ways to generate better traction in sand.

Ken said one industry that most may not think would benefit from this model would be the nuclear power industry.

“Recent disasters such as the Fukushima nuclear meltdown have highlighted international efforts toward the design of “meltdown-proof” pebble-bed reactors,” he told RedOrbit. “In pebble-bed reactors, the nuclear fuel is encased in many billiard-ball sized pebbles, and over the course of months, the packing of pebbles slowly drain through the reactor like a gumball machine.”

He said one of the engineering difficulties is trying to track the locations of all the pebbles within the reactor during the slow draining process.

“Continuum models like the one we are presenting could address this by predicting the average motion of the pebbles within the reactor, regardless of the shape, fill-level, or out-flow rate of the reactor vessel,” Kamrin said.

Ken, as well as colleagues who worked on the project with him, published the paper detailing the new model in the journal Physical Review Letters.

Admitting A Weight Problem Is The First Step To Recovery

University of Illinois researchers have surveyed more than 3,500 college students, finding more than a third of them reported their weight inaccurately. Of the students surveyed, overweight and obese men were most likely to guess low on their weight.

According to Margarita Teran-Garcia, a University of Illinois professor of food science and human nutrition, accepting a weight problem is half of the battle.

“This misperception is important because the first step in dealing with a weight problem is knowing that you have one,” said Teran-Garcia.

This study was conducted as a part of the Up Amigos project, a collaboration between scientists at the University of Illinois and the Universidad Autónoma de San Luis Potos, Mexico. According to the research, 3,622 Mexican students ranging from 18 to 22 years old underwent physical exams wherein their height, weight, and body mass were measured. This data was measured against surveys completed by the students about the status of their weight.

The results found 33.6% of the college-aged men were overweight obese, though only 16.9% of them reported themselves as such. Women in the same age group were more realistic about their weight. 27.8% of college aged women were reported as overweight or obese, and 21.2% of them reported themselves accurately.

Flavia Cristina Drumond Andrade, one of the researchers involved in this study, reported heavier students were less likely to estimate their weight correctly. Teran-Garcia says this study proves identifying weight problems early can affect ones health later in life.

In a press release announcing the study, Teran-Garcia said, “If these young people follow the wrong trajectory, continuing to accumulate weight, they are likely to develop heart disease and diabetes. It´s much better if they deal straightforwardly with the fact that they´re gaining weight while they´re young.”

Teran-Garcia and her team are focusing on Latino students.

According to Teran-Garcia. Mexico has the highest rates of diabetes and obesity in the world. As the Latino population grows and moves to the United States, their weight problems and cultural issues move with them.

The 18 to 22 year olds studied in this research are at a prime age for both education and intervention, according to Teran-Garcia. “In Hispanic culture, young people often become parents in their early to mid-twenties. When women are at healthy weights, they have healthier pregnancies. When a pregnant woman is obese, there are long-term consequences for the baby.”

While this study proves the differences in weight documented and weight reported in Latino students, the Centers for Disease Control (CDC) and International Journal of Pediatric Obesity say American teens are even less likely to accurately report their weight.

While there were only a few students to overestimate their weight in the study, those who did were more often younger females with less-educated parents. Researchers worry about these students, as females who think they weigh more than they do have an increased risk for developing anorexia or bulimia. Some of these students will have to undergo the physical exams once more, as Teran-Garcia and her team plan to follow these students for the next few years.

“We will be able to follow many of these students for some time. We expect to have an exit interview with at least a third of our study participants when they leave college,” Andrade said.

The study appeared in a recent issue of Body Image. Co-authors are Flavia Cristina Drumond Andrade, Marcela Raffaelli, and Jilber A. Jerman of the U of I, Celia Aradillas Garcia of the Universidad Autónoma de San Luis Potos in Mexico, and the Up Amigos 2009 study group.

Apple Gets Rare Downgrade Over iPhone Subsidy Concerns

Shares of Apple Inc. were downgraded for the first time in six months on Monday over doubts that wireless network operators will continue their generous subsidies of the popular iPhone.
“We expect post-paid wireless operators to remain firm in their plan to stunt the pace of phone upgrades in 2012 and we expect to see some initial evidence of their success in the current quarter,” wrote BTIG Research analyst Walter Piecyk in a note to clients.
Any changes to carrier subsidies of the iPhone — the highest in the mobile handset industry — would mean fewer upgrades, wrote Piecyk.
“This will increase the need for Apple to grow its business in the pre-paid dominated emerging market space, in which handset subsidies are a rarity and the $600 ASP (average selling price) of the iPhone represents a big chunk of a household´s monthly income.”
Piecyk moved his recommendation on Apple´s stock from “Buy” to “Neutral”, and removed his 12-month price target of $600, a price the stock surpassed earlier this year.
Apple´s current iPhone models are priced at $199, $299, and $399, but carriers subsidize those prices by hundreds of dollars per unit.  Wireless operators were initially happy to provide the subsidies based on expectations that customers who use the iPhone would increase their monthly wireless bills, offsetting the subsidies and then some.
But that hasn´t been the case, particularly for AT&T, Apple´s largest customer.
AT&T, Sprint, Verizon, Vodafone, Deutsche Telecom, Telefonica and America Movil are among the carriers expected to scale back on their subsidized iPhone upgrade offers, Piecyk said.
This could lead Apple to miss its revenue by up to $1 billion from the current consensus analyst estimate for the fiscal third quarter, he said.
The last analyst to downgrade Apple, the world´s largest company, was BGC Partner´s Colin Gillis last October.   Since then, Apple´s stock has soared more than 60 percent amid better-than-expected iPhone sales, the launch of a new iPad and Apple´s declaration of a dividend.
As of today, forty-five analysts have “buy” ratings on Apple´s stock, while just five have a “neutral” rating and only one has a “sell” rating, CNBC reported.
Apple is also the most widely held stock among U.S.-based hedge funds.
Piecyk said he believes the catalyst for a pullback in Apple´s stock is the lack of a groundbreaking new product launch in 2012.
Unlike many of his peers, Piecyk does not expect an Apple iTV flat panel to be launched this year.
“We believe that investors should take a breather during the expected strength of this quarter and the rapid rise in the stock,” he wrote.
However, Piecyk said he is not an “Apple hater,” and that he is “completely bought into the Apple ecosystem.”
“Our family of six owns 4 iPads, 2 iPhones, 1 iPod Touch, 2 MacBooks, 1 iMac and two Apple TV’s; and that is just the stuff in active use,” he wrote.
“After dinner, the kids prefer to stream YouTube or play games on the iPads rather than watch the tons of available programming stored on the networked DirecTV HD DVRs.”
Shares of Apple´s stock were down as much as one percent in early morning trading on Monday on news of the downgrade, but turned positive before 11am EST.  The stock was up $2.55, or 0.4%, for the day, closing at $636.23.

Discovery Flyover of DC Scheduled for April 17

NASA‘s retired Space Shuttle Discovery will be flying over portions of Washington D.C. on the morning of April 17 as it travels en route to the Smithsonian National Air and Space Museum, where it will be displayed, the American space agency announced on Monday.

The flight is scheduled to occur between 10am and 11am local time and will involve a modified Boeing 747 known as a Shuttle Carrier Aircraft (SCA) with the shuttle mounted on top of it, NASA and Space.com‘s Robert Z. Pearlman said. The flight will launch from the Kennedy Space Center in Florida and will end at Washington Dulles International Airport, but not before it flies approximately 1,500 feet above the Washington D.C. metropolitan area.

The precise route that the flight will take and the time at which it occurs depends upon both the weather and will not be revealed until the day of the flight for security reasons, Pearlman reported on April 4. However, the planned journey sets up “the possibility of flyovers of the city’s historic monuments and federal buildings,” he added. Some possible flyover locations, NASA said in a statement, includes the National Mall, Reagan National Airport, National Harbor and the Smithsonian’s Udvar-Hazy Center.

Should the flight need to be postponed, NASA officials said that they will release an additional advisory at that time.

In preparation for the historic April 17 flight, the aeronautics and space administration was scheduled to send out a pair of T-38 training jets to complete a flyover of Washington D.C. with the assistance of the FAA. That flyover, which was to take place last Thursday, was scheduled in order to scout out the landscape and narrow down a possible route for Discovery’s journey to the National Air and Space Museum.

“They’re going to be flying to various locations and taking photographic imagery to scout out possible routes and the areas that they might want to fly over if weather will permit on the day of Discovery’s arrival,” NASA spokesman Mike Curie told Space.com. “These flights will help determine how viable it might be to do a flyover of Washington with the shuttle carrier aircraft.”

According to NASA, Discovery completed 39 missions and spent a total of 365 days in space during its lifetime. As part of those flights, it traveled nearly 150 million miles and orbited the Earth a total of 5,830 times. The agency says that the retired shuttle is being sent to the Smithsonian in order to “begin its new mission to commemorate past achievements in space and to educate and inspire future generations of explorers.”

Image Caption: Space Shuttle Discovery leaves Edwards on the back of a modified Boeing 747. The Aug 19 takeoff marked the first leg of the orbiter’s cross-country trek to its home at Kennedy Space Center in Florida. Credit: U.S. Air Force photo by Senior Airman Jet Fabara

Genetic Factors May Increase Risk Of Childhood Obesity

Common childhood obesity may now be considered genetic. A researcher at the Children´s Hospital of Philadelphia led the study, considered to be the largest of its kind, to determine the origins of this pediatric condition. According to his research, there are at least two new genetic variations responsible for increasing the risk of common childhood obesity.

Lead investigator and associate director of the Center for Applied Genomics at The Children´s Hospital of Philadelphia Struan F. A.  Grant, Ph.D. said of the study, “This is the largest-ever genome-wide study of common childhood obesity, in contrast to previous studies that have focused on more extreme forms of obesity primarily connected with rare disease syndromes.”

“As a consequence, we have definitively identified and characterized a genetic predisposition to common childhood obesity.”

This study appeared online in Nature Genetics and was conducted in part by the Early Growth Genetics (EGG) Consortium.

Obesity continues to receive public attention as one of the major health concerns affecting modern society. Even more alarming is the amount of children who are reported as being obese. According to research, children who are obese have a higher risk of death once they become adults. This new research suggests there may be more factors at play in childhood obesity. Family history and even genetics may increase the risk of childhood obesity, as well as poor food choices and sedentary habits.

In a press release announcing the new results, Dr. Grant said being able to work with the EGG gave him the statistical power to determine genetic signals in the children studied.

Dr. Grant included 14 previous studies in his research, including 5,530 cases of childhood obesity and 8,300 control subjects. In looking at the data, Dr. Grant and his team found two instances of genetic evidence which could be responsible for childhood obesity. Additionally, the team also found two other genetic variants which may also increase obesity risks.

“The known biology of three of the genes,” added Grant, “hints at a role of the intestine, although their precise functional role in obesity is currently unknown.”

Dr. Grant believes this evidence isn´t entirely conclusive, though it does give researchers a place to start when they study childhood obesity.

“This work opens up new avenues to explore the genetics of common childhood obesity,” said Grant in the press release. “Much work remains to be done, but these findings may ultimately be useful in helping to design future preventive interventions and treatments for children, based on their individual genomes.”

According to the Centers for Disease Control and Prevention, (CDC), Childhood obesity has more than tripled in the past 30 years. The CDC says this obesity is caused by a “caloric imbalance,” or too few calories expended for the amount of calories consumed. They also say genetic factors as well as environmental and behavioral factors can also increase the risk of childhood obesity. Keys to preventing childhood obesity, as outlined by the CDC, include healthy lifestyle habits, healthy eating and physical activity.