Small Fish Overtake Big Fish In Food Web

Over-fishing by humans has led to fewer big, predatory fish in the world’s oceans, leaving smaller fish to thrive and double their numbers over the past century, scientists reported on Friday.

Tuna, cod, and groupers, among others, have declined around the world by as much as 66 percent while the number of anchovies and sardines has surged in the absence of those bigger fish, said researchers at the University of British Columbia (UBC).

People around the world continue to fish harder, but are coming up with fewer and fewer numbers in their catch, indicating that fishers may have maxed out the ocean’s capacity to provide the world with food.

“Over-fishing has absolutely had a ‘when cats are away, the mice will play’ effect on our oceans,” Villy Christensen, professor at UBC’s Fisheries Center, told AFP. “By removing the large, predatory species from the ocean, small forage fish have been left to thrive.”

Christensen, who presented the research findings at the American Association for the Advancement of Science (AAAS) annual conference in Washington, said his team also found that more than half of the decline in the predatory fish population has taken place over the last 40 years.

Christensen’s team examined more than 200 global marine ecosystem models and extracted more than 68,000 estimates of fish biomass from 1880 to 2007 for their study. They did not use catch numbers reported by governments and fishing operators.

“It is a very different ocean that we see out there,” said Christensen. “We are moving from wild oceans into a system that is much more like an aquaculture farm.”

While small fish are becoming more populous, they are also being used more and more for use as fishmeal in fisheries, Christensen said. “Currently, forage fish are turned into fishmeal and fish oil and used as feeds for the aquaculture industry, which is in turn becoming increasingly reliant on this feed source.”

Despite the spike in small fish, the overall supply of fish is not increasing to meet human demand, according to researchers.

“Humans have always fished. Even our ancestors have fished. We are just much much better at it now,” Reg Watson, a scientist at UBC, told AFP’s Kerry Sheridan.

About 76 trillion tons of seafood were reported in 2006, meaning about “seven trillion individuals were killed and consumed by us or our livestock,” said Watson. Fishing efforts have been growing over the past several decades, reaching a collective point of 1.7 billion watts, or 22.6 million horsepower, worldwide in 2006, he added.

In terms of energy use, that would amount to 90 miles of “Corvettes bumper to bumper with their engines revving,” he said.

“It looks like we are fishing harder for the same or less result and this has to tell us something about the oceans’ health. We may in fact have hit peak fish at the same time we are hitting peak oil,” Watson stressed.

Christensen, who urges consumers to shift their attention down the marine food chain from large predatory fish to more unusual fish, echoes that of celebrity chef Jamie Oliver, who suggests we eat more coley, mackerel, dab, pouting, herring and sardines.

“I know you like your fish suppers, but our appetite for the same fish, day in, day out, is sucking the seas dry,” Oliver told the Guardian. “I wouldn’t bother waiting for the politicians to sort this one out, guys, you can really help from the comfort of your own kitchen … Lay off the cod, haddock and tuna, diversify and cook up a wider range of fish.”

Seafood makes up a large part of the global human diet according to researcher Siwa Msangi of the International Food Policy Research Institute, who told AFP that the rise in demand is being driven mainly by China.

Globally, “meat provides about 20 percent of the per capita calorie intake and of that… fish is about 12 percent,” he said. But almost 50 percent of the increase in the world’s fish consumption for food comes from eastern Asia, and “42 percent of that increase is coming from China itself,” said Msangi.

“China is a driver of both the demand and the supply side. That is really why the management issue becomes so important,” he added.
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Jacqueline Alder of the UN Environment Program suggests that the world needs to see cuts in the amount of fishers trolling the world’s oceans and also a cut in the number of fishing days in order to allow global fish stocks to regain their numbers.

“If we can do this immediately we will see a decline in fish catches. However, that will give an opportunity for the fish stocks to rebuild and expand their populations,” Alder told AFP.

Although, when coupled with forecasts about the impact of climate change, projections of future fish numbers decline even further.

“Our study indicates indeed we may get a double whammy from climate change,” said Christensen. “In the sense that higher water temperatures… are going to mean there will be less fish in the ocean.”

Furthermore, a rise in wild forage fish populations would have damaging effects on marine ecosystems. These fish eat more of the zooplankton in the oceans, which means that the next stage down the food chain — the plant plankton normally consumed by the zooplankton — blooms. “You get into a situation where you get a green soup, you get anaerobic conditions [low oxygen levels]. There are clear examples in the Black Sea,” said Christensen.

Predatory fish are an vital part in food chains, he added, preventing the spread of disease, for example. “In England some years ago, there was a crisis where they had killed a lot of the predators such as eagles. You had rabbits that got problems with diseases, there was massive die-off, the sick ones were not being eaten by the predators. We see less stable ecosystems if we do not have predators there,” he explained.

The sheer drop in top predator fish was also linked, in a separate study presented at the AAAS, to the rise in global fishing capacity. This has increased by 54 percent from 1950 to 2010 with no sign of a decrease in recent years.

“We need to cut back fishing efforts,” said Christensen. “Society needs to decide what we want with the ocean ““ do we want to turn it into a farm? Or do we want to have something that is more of a natural ecosystem?”

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Study Explores Ability Of Professional Dancers To Return To Their Career After Hip Arthroscopy

Hip injuries common for dancers, with more than 20 percent of annual injury rates

A new study has identified factors that predict the ability of a professional dancer to return to professional performance after hip arthroscopy surgery. The study by Hospital for Special Surgery investigators will be presented at the American Academy of Orthopaedic Surgeons annual meeting, held Feb. 15-19 in San Diego, Calif.

The results of this study indicated that ballet dancers were significantly less likely to be able to return to work compared with modern dancers or dance theater performers. Older age and having a variety of hip abnormalities also influenced outcome. “This data is helpful to patients trying to reach a decision regarding surgery. We now have information on the time frame for recovery as well as the likelihood of being able to return to dance,” said Douglas Padgett, M.D., chief of Adult Reconstruction and Joint Replacement at Hospital for Special Surgery, who led the study.

Professional dancing is a particularly physically demanding occupation with annual injury rates of 67% to 95%, with over 20% of these being hip injuries. “Hip injury is very common in professional dancers. Many of these individuals tend to be hyper mobile. They are performing very rapid loading and landing activities and an extreme range of motions,” said Dr. Padgett. Treatment can range from physical therapy to arthroscopic or open surgery.

HSS launched the study because there was no data available to help counsel professional dancers about their chances of returning to work after hip arthroscopy. The retrospective study looked at 40 professional dancers who had hip arthroscopy conducted by a single surgeon at Hospital for Special Surgery. One patient had hip arthroscopy in both hips and all others had only one hip operated on. Of the 31 female and nine male dancers, 15 were ballet dancers, 14 were involved in musical theater, and 11 were modern dancers. The average follow-up was 29.8 months.

The primary outcome was return to professional dance for at least three months, and the study found that the majority of dancers, 73% (29), were able to do this. The average return to work was 7.4 months. Younger age was a predictor of success. The average age of dancers who returned to work was 30.4 compared with 39.7 in those who did not return. Of the three types of dance, ballet dancers were less likely to return to their career””with only 60% returning to work. This is in comparison to 73% of modern dancers and 79% of dancers in musical theater. Ballet dance tends to involve the need for greater range of motion and holding the leg in more extreme positions which appears to be more difficult during the recovery phase, according to Dr. Padgett.

Other factors also influenced outcome. Dancers who returned to work had less degeneration of the articular cartilage of the hip joint as determined by high resolution MRI. Patients with normal radiographs (89%) and Cam impingement (70%) had higher return to work than those with hip dysplasia (64%). Cam type impingement describes a bump on the surface of the ball (femoral head) that jams on the rim of the socket. Hip dysplasia is a condition where the cavity in the pelvic bone that forms the hip socket has limited coverage of the head of the femur, the round ball that fits inside the socket. To compensate for this loss of coverage, the labrum (a type of fibrocartilage) becomes hypertrophied and is at risk for tearing.

Dr. Padgett said that identification of factors linked to better outcomes should help doctors with their ability to counsel patients. “You can tell the patient, you have this problem, you have a labral tear and some morphological abnormality in the shape of your hip joint and if you have an operation, you stand a 75% chance of getting back and continuing to dance,” Dr. Padgett said. “But factors like a little bit of early arthritis, being over the age of 35, you have this hip dysplasia and you are a ballerina””this is a less favorable situation for full return to work. So, if I have that person come into my office, I don’t say, ‘you have a 75% of chance to get back to dance.’ That number in their case may be down to fifty-fifty, and with that information we can discuss the pros and cons of surgery versus some nonoperative approach.”

Armed with this information, a dancer may decide to perhaps just finish up the season and call it a career. “Professional dancers at 35 are relatively rare because at that point, their body just can’t take it anymore. It’s really brutal on your body.”

Also useful for doctors is the information gathered from the study during the preoperative diagnoses that showed that 54% of patients had hip dysplasia and 24% had Cam impingement. “This type of information is good for both the patient and the physician. It is good for the physician to be on the lookout for these types of injuries in people who are in the performing arts. To simply attribute vague hip pain to ‘oh, you pulled a hip muscle’ is probably not appropriate,” Dr. Padgett said. “In 2011, if you have somebody who has pretty significant hip pain and the X-rays are somewhat unremarkable, the next step would be to get an MRI.”

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John Theurer Cancer Center Orthopedic Oncologist Shares New Limb Sparing Surgical Techniques

11 educational videos document surgical techniques mastered by few surgeons in an effort to improve patient outcomes worldwide

James C. Wittig, M.D., chief of the division of skin and sarcoma cancer at the John Theurer Cancer Center at Hackensack University Medical Center will present eleven different educational videos on innovative approaches to orthopedic oncology at the upcoming American Academy of Orthopaedic Surgeons Conference. Dr. Wittig is known for inventing some of the most-used best practices in limb-sparing surgery. In 2009, he and his colleagues began filming their surgeries so that other surgeons across the globe could use their radically innovative techniques.

“We have spent years developing some of the best practices in limb-sparing surgery, and sharing this knowledge is going to benefit patients worldwide,” said Dr. Wittig. “Conference attendees represent some of the finest minds in orthopedics today, so to be chosen to lead such a great number of presentations is an honor and speaks to the importance of limb sparing surgery and its significance to the field.”

The videos range in content from radical resection and reconstruction of a distal femur tumor to a radical sacrectomy and reconstruction for a high-grade primary sarcoma of the sacrum. All of the educational videos describe various orthopedic oncology procedures pertaining to radical limb sparing surgery and reconstruction for bone and soft tissue tumors in different locations, representing state-of-the-art approaches to these surgeries.

“The physicians and staff of the John Theurer Cancer Center are focused on delivering extraordinary care,” said Andrew Pecora M.D., F.A.C.P., C.P.E., chief innovations officer and professor and vice president of cancer services, John Theurer Cancer Center. “The multimedia presentations by Dr. Wittig and his team exemplify this approach from both a patient care and an educational perspective”

The conference is held in San Diego, California from February 15-19 featuring international experts in orthopedics as well as a keynote address from one of the greatest football coaches of all-time Lou Holtz. Limb sparing surgery and innovative approaches to orthopedic oncology have increasingly assumed a more prominent role within both cancer and orthopedic care. The work by Dr. Wittig and colleagues points to increasing options for patients with tumors in difficult locations of the body and how new approaches are improving patient care.

Titles and short descriptions of the video presentations Dr. Witting and colleagues will present are listed below:

   1. Osteosarcoma of Distal Femur: Radical Resection & Reconstruction with Distal Femur Tumor Prosthesis
      Authors: James C. Wittig, Camilo E. Villalobos, Brett Hayden, Andrew Silverman, Benjamin Lerner, Martin M Malawer

      This video describes limb-sparing resection of an Osteosarcoma involving the distal femur and knee joint. A modular segmental distal femur tumor prosthesis is utilized to reconstruct the knee joint. Emphasis is placed on meticulous neurovascular dissection and multiple muscle transfers to optimize function and minimize complications. The procedure described is a safe, reliable technique for limb sparing surgery for sarcomas of the distal femur.

   2. Limb-Sparing Total Scapula & Proximal Humerus (Tikhoff-Linberg) Resection and Reconstruction
      Authors: James C. Wittig, Camilo E. Villalobos, Brett Hayden, Andrew Silverman, Benjamin Lerner, Martin M Malawer

      This video depicts a 60 year old male patient who was presented with a fungating squamous cell carcinoma involving the shoulder girdle. The radiologic studies demonstrated an extensive loss of soft tissue overlying the scapula, proximal humerus and distal clavicle. The patient underwent a limb sparing radical resection of the left scapula as well the proximal humerus including the deltoid, rotator cuff muscles, portions of the trapezius and the clavicle. A modular proximal humerus tumor prosthesis was used for reconstruction. It was stabilized to the clavicle and second rib with heavy Dacron tapes. Multiple muscle rotation flaps were used for coverage and to stabilize the prosthesis

   3. Intraarticular Proximal Humerus Resection and Prosthetic Reconstruction for a Pathologic Fracture
      Author: James C. Wittig, Andrew Silverman. Camilo E.Villalobos, Brett Hayden, Benjamin Lerner

      This is a patient with a pathologic fracture of his right humerus due to metastatic renal cell carcinoma. Dr. Wittig and his team performed an intraarticular resection of the right proximal humerus. A modular proximal humerus tumor prosthesis was utilized for reconstruction. Static and dynamic methods were utilized for stabilizing the prosthesis. Reconstruction of the glenohumeral ligaments with gore-tex aortic graft was performed to provide multidirectional stability. Multiple muscle transfers and rotational flaps were performed for dynamic stabilization as well as to power the shoulder girdle and cover the entire prosthesis with soft tissue. The goal of the reconstruction is to stabilize the shoulder girdle for optimal hand and elbow function without compromising rotation. Our patients have been pain-free and have shown good elbow and hand function.

   4. Primary MFH of Proximal Tibia: Limb-Sparing Resection with Prosthetic and Soft Tissue Reconstruction
      Author: James C. Wittig, Camilo E. Villalobos, Brett Hayden, Andrew Silverman, Benjamin Lerner, Martin M Malawer

      A limb-sparing resection of the proximal tibia is performed for a patient with a primary Malignant Fibrous Histiocytoma (MFH) of bone. A modular segmental proximal tibia endoprosthesis is used to reconstruct the bony defect and knee joint. Emphasis is placed on neurovascular dissection and reconstruction of the extensor mechanism with a medial gastrocnemius muscle flap.

   5. Radical Resection of the Distal Humerus and Reconstruction with a Distal Humerus Tumor Prosthesis
      Authors: James C. Wittig, Andrew Silverman, Brett Hayden, Camilo E. Villalobos, Benjamin Lerner

      The distal humerus is a relatively rare site for developing a tumor. Limb sparing resection and reconstruction is challenging due to the close proximity of several critical neurovascular structures as well as the paucity of surrounding soft tissues. The video describes an anterior approach for resecting tumors involving the distal humerus and reconstruction with an endoprosthetic replacement. Limb-sparing resection for tumors involving the distal humerus through an anterior approach and reconstruction with a modular distal humerus tumor prosthesis and multiple muscle transfers is a safe and reliable method for treating tumors in this location.

   6. Chondrosarcoma of the Proximal Femur: Limb-Sparing Resection and Prosthetic Reconstruction
      Authors: James C. Wittig, Andrew Silverman, Camilo E. Villalobos, Brett Hayden, Benjamin Lerner

      A limb-sparing resection of a Proximal Femur is performed for an 81 year old male patient with a Chondrosarcoma of the right proximal femur. Modular segmental proximal femur tumor prosthesis is utilized to reconstruct the proximal femur. Emphasis is placed on preservation of neurovascular structures and employment of major muscle rotations to optimize post-operative hip function and minimize infection. Proximal femur resection with endoprosthetic reconstruction is a complex surgical procedure. Preservation of the acetabulum and joint capsule, capsulorraphy, and reconstruction of the abductor mechanism are major determinants of joint stability. This reconstruction can also be used for a variety of nononcologic indications, as for major total hip revision surgeries and persistent infection.

   7. Intermuscular Liposarcoma of the Posterior Thigh: Radical Resection and Sciatic Nerve Preservation
      Authors: James C. Wittig, Brett Hayden, Andrew Silverman, Benjamin Lerner, Camilo E. Villalobos

      This video demonstrates radical resection of an intermuscular myxoid liposarcoma of the posterior thigh in a 39 year old patient. The surgical procedure included radical resection of the intermuscular tumor as well as the use of multiple muscle rotation flaps for soft tissue closure. Strong emphasis in this video is placed on sciatic nerve dissection, mobilization, and preservation prior to tumor removal. This reconstruction technique is a safe and reliable method for treatment of soft tissue tumors in this location.

   8. Radical Sacrectomy and Reconstruction for a High Grade Primary Sarcoma of the Sacrum
      Authors: James C. Wittig, Benjamin Lerner, Andrew Silverman, Brett Hayden, Camilo E. Villalobos, Sheeraz Qureshi

      This video details a radical subtotal sacrectomy and reconstruction for a high grade primary sarcoma. Sarcomas of the sacrum are extremely rare. Resection of sacral tumors is complex and risky, often requiring resection of multiple sacral nerve roots. These surgeries are associated with multiple complications. The patient, a 43 year old woman, presented with a sarcoma arising from the right side of her sacrum. The tumor had a large soft tissue component. Resection and reconstruction was undertaken through three separate approaches. This video details the steps of this complex surgical procedure.

   9. Spinopelvic Fusion and Gluteus Maximus Muscle Rotation Following Radical Sacral Tumor Removal
      Authors: James C. Wittig, Benjamin Lerner, Andrew Silverman, Brett Hayden, Camilo E. Villalobos, Sheeraz Qureshi

      This video details a radical subtotal sacrectomy and reconstruction for a high grade primary sarcoma. Sarcomas of the sacrum are extremely rare. Resection of sacral tumors is risky, often requiring resection of multiple sacral nerve roots. These surgeries are associated with multiple complications. The patient, a 43 year old woman, presented with a sarcoma arising from the right side of her sacrum. The tumor had a large soft tissue component. Resection and reconstruction was undertaken through three separate approaches. The spine was fused to the iliac wings and the entire defect was covered with bilateral glutes maximus rotational flaps.

  10. Revision Arthroplasty with a Total Femur Replacement for Multiply Failed Total Hip and Total Knee Replacement
      Author: Calin Moucha, Richard Greendyk, Benjamin Lerner, Andrew Silverman, Brett Hayden, Camilo E. Villalobos and James C. Wittig

      The number of revision total knee replacement (TKR) surgeries done worldwide is increasing at a rapid pace. On rare occasions the failed TKR needs to be revised during the same surgery as an ipsilateral failed total hip replacement. In these instances the femoral bone stock is usually highly deficient and a total femoral replacement may be required. This video demonstrates a surgical technique that utilizes a total femoral replacement prosthesis for revision arthroplasty. After an extensive negative infection work-up a decision was made to undergo the procedure described. The video highlights the extensile exposure, resection of the femur, removal of a stemmed, well-fixed tibial component, and reconstruction using a total femoral prosthesis.

  11. Massive Reconstruction of Femur with a Total Femur Replacement for Failed Arthroplasties
      Author: Calin Moucha, Richard Greendyk, Benjamin Lerner, Andrew, Brett Hayden, Camilo E. Villalobos and James C. Wittig

      The number of patients who require revision surgery for a failed total hip arthroplasty is increasing at a rapid rate. While multiple reconstructive options are available in the majority of cases, on rare occasions the femoral bone stock is so deficient that standard revision implants cannot be securely fixed in the remaining bone. This video demonstrates a surgical technique that utilizes a total femoral replacement prosthesis for revision arthroplasty of a highly deficient femur. The type of implant and surgical technique used in this case should be included in the revision surgeons armamentarium for treating patients with these increasingly more common, difficult cases.

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Link Between Ancient Climate Change And Mass Extinction

Researchers use a ground-breaking technique that reveals a relationship between cooler temperatures and Earth’s second largest mass extinction, which occurred about 450 million years ago

In the Late Ordovician Period of Earth’s geologic history, about 450 million years ago, more than 75 percent of marine species perished and Earth scientists have been seeking to discover what caused the extinction. It was the second largest in Earth’s history.

Now, using a new research method, investigators believe they are closer to finding an answer.

Employing a new way to measure ancient ocean temperatures, a team of researchers at the California Institute of Technology (Caltech) recently discovered a link between ancient climate change and the Late Ordovician mass extinction. The team found the extinction event occurred during a glacial period when global temperatures became cooler and the volume of glacial ice increased.

Both the changes in temperature and the increase of continental ice sheets are factors that could have affected marine life in these ancient waters, said Woodward Fischer, an assistant professor of geobiology at Caltech.

“Our tools are getting better to ask more questions about ancient climate, so we’re really shaping our picture of what that world was like,” he said.

In the past, measuring ancient ocean temperatures was based on measuring the ratios of oxygen isotopes found in minerals from ocean water. The challenge was knowing the concentration of isotopes in the ocean at that time, which was needed to determine past water temperatures. But, because there is no direct record of the isotopic composition of ancient oceans, it was difficult to determine the water temperature.

The new method, developed in the laboratory of John Eiler, Sharp Professor of Geology and professor of geochemistry at Caltech, determines the temperature of the ocean by examining the spatial organization of isotopes in fossils that existed in the Late Ordovician Period; in particular, the method looks at the extent to which rare isotopes group together into the same chemical unit in a mineral structure.

This new method “requires really well-preserved minerals, so we used fossils,” explained Fischer. “Shells are ideal for this technique.”

Fossilized marine species shells were used from present-day Quebec, Canada, and from the mid-western United States.

Fischer said the types of species that went extinct during the Late Ordovician Period included mostly benthic invertebrates, or invertebrates that live on the ocean floor and filter plankton for food. These were organisms such as trilobites and brachiopods. Paleozoic corals and cephalopods, which Fisher described as resembling “squids in a tube,” were impacted as well. Some vertebrates, primarily fish, also were impacted by the change in global temperature, but fossil evidence of these organisms is less common.

Eiler explained that the findings of this study revealed that during the Late Ordovician, the temperatures of tropical oceans were higher than they are today, but for a brief period, experienced a drop in temperature by five degrees. At the same time, the volume of ice in the poles expanded. After this glacial period, the ocean temperatures rose, and the ice volume returned to its earlier, lower amount.

“We’ve observed a cycle of climate variability,” said Eiler, who explained that these findings can be used to learn more about changes in climate today.

By Ellen Ferrante, NSF

Image Caption: This image shows coastal outcrop exposure of the Late Ordovician Ellis Bay Formation, Anticosti Island, Quebec, Canada. Credit: Seth Finnegan

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Researchers Conducting ‘Avatar’-Like VR Experiments

It may sound like the stuff of science fiction films, but researchers at the Ecole Polytechnique F©d©rale de Lausanne (EPFL) Brain Mind Institute are using virtual reality and brain imaging technology to study the feeling of owning one’s body, as well as near-death and out-of-body experiences.

According to a February 17 press release, the study, which is being led by EPFL and University of Geneva neurologist Olaf Blanke, is believed to be “the first experimental, data-driven approach to understanding self-consciousness.”

By using both VR technology and cognitive science techniques, they performed a series of experiments in which they immersed subjects into the body of a virtual human, ala the popular James Cameron motion picture ‘Avatar.’ Each participant in the study had their brain activity monitored through a skullcap equipped with electrodes, and were then inserted into mock 3D environments through “a head-mounted stereoscopic visor or projections on a large screen.”

They then performed different techniques to break the participants out of their physical comfort zones by doing things like touching their real bodies alternately at the same time or at different times as their avatar or placing them in a virtual body of the opposite gender.

They measured the brain activity the whole time, and they hope that their experiments will lead to “advanced in the fields of touch and balance perception, neuro-rehabilitation, and pain treatments, contribute to the understanding of neurological and psychiatric disease, and have impacts on the fields of robotics and virtual reality.”

However, according to Telegraph Science Correspondent Richard Alleyne, Blanke and his colleagues are also looking to apply the results of their study to more spiritual or supernatural areas.

“Throughout history people have described how they have floated from their bodies and looked back at themselves, often when close to death or on the operating table,” Alleyne wrote in a Friday article. “The accounts have been so vivid that they are often cited as proof of the existence of the soul or Heaven.”

“But scientists now claim they have dispelled this myth by artificially creating an out-of-body experience using computers and cameras,” he added. “They believe the feeling of detachment occurs when the brain becomes confused by conflict between the senses–and is not proof of any ‘spiritual dimension’ to existence.”

The unpublished study was presented at the annual meeting of the American Association for the Advancement of Science (AAAS) on Thursday.

Image Caption: Olaf Blanke conducts experiment to understand the way the brain represents the body by combining VR induced illusions and brain signal readings to better understand the cognitive basis for spatial representation. Credit: EPFL

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Mobile Phone Serves As ECG Device

A Singapore company has developed a new phone that can take your pulse when you press your fingers on a receptor, then sends the results to a 24-hour medical call center that can determine if you need medical assistance or not.

The new EPI Life mobile phone is equipped with its own mini electrocardiogram (ECG).

“We think it’s a revolution. It has clinical significance,” EPI medical chief Dr. Chow U-Jin told AFP at the mobile industry’s annual conference in Barcelona, Spain.

“Anywhere in the world you can use it as a phone but you are also able to transfer an ECG and get a reply,” said Chow.

“If you get a normal reply it will just be an SMS.” But, “if it’s severe, you get a call: ‘Sir, an ambulance is on the way’,” he added.

EPI Life has three hospitals in Singapore, all of which will carry the phone users’ history.

The price tag on the phone runs about $700 US, about the price of a high-end smartphone model, and so far about 2,000 phones have been on the market since 2010.

Chow said the phone is geared toward users with “heart disease.” He said phone owners can choose from three different packages offering 10, 30 or 100 tests per month.

There is a much cheaper mini version of the phone for $99 that has a smaller receptor that links via Bluetooth to your smartphone, which is due out soon in Spain and France.

The EPI Life mobile phone is one of many new mobile health initiatives unveiled in Spain. Many services rely on SMS or MMS messages that older mobile phones can receive.

Health Company, an outfit that covers Saudi Arabia and Kuwait, sends medical information to more than 425,000 customers in Arab and English.

“You could also send a consultation through SMS,” said company vice president Fahad S. Al-Orifi. “This SMS will go to our website where our doctor answers you to your mobile.”

Kazi Islam, CEO of Grameenphone of Bangladesh, said mobile health is developing in poorer countries where it can be a vital and crucial tool to save lives that may otherwise be lost.

In his country there are less than 3,000 hospitals for the more 150 million people, but some 66 million people there have access to mobile phones.

“Most women don’t have access to information of health. Seventy-five percent of women from 15 to 24 have never heard of STIs (sexually transmitted infections),” Islam told AFP.

“With a simple SMS we are sending information to expectant mothers. This is a necessary help.”

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Permafrost Thaw Could Speed Up Global Warming

Scientists at the National Snow and Ice Data Center (NSIDC) in Colorado estimate that if global warming continues even at a moderate pace, a third of the earth’s permafrost will be gone by 2200.

A study released Wednesday, based on UN Intergovernmental Panel on Climate Change (IPCC) scenarios, warns that global warming could cause up to 60 percent of the world’s permafrost to thaw by 2200 releasing huge amounts of carbon into the atmosphere increasing the rate of climate change, AFP is reporting.

NSIDC scientists used a computer model to predict how much carbon the thawing permafrost would release and came up with the staggering figure of 190 gigatons by 2200. “That’s the equivalent of half the amount of carbon that has been released into the atmosphere since the dawn of the industrial age. That’s a lot of carbon,” NSIDC scientist Kevin Schaefer, the lead author of the study says.

Predicting the world could see 59 percent of the permanently frozen underground layer of earth thaw out, organic matter, having been trapped in the permafrost for tens of millennia will begin to decay, releasing carbon into the atmosphere.

Escaping carbon from plant material, primarily roots trapped and frozen in soil during the last glacial period that ended roughly 12,000 years ago, he said. Schaefer likened the mechanism to storing broccoli in a home freezer. “As long as it stays frozen, it stays stable for many years,” he said. “But if you take it out of the freezer it will thaw out and decay.”

Schaefer continued by saying carbon released from melting permafrost has to be accounted for in global warming strategies. “If we don’t account for the release of carbon from permafrost, we’ll overshoot the C02 concentration we are aiming for and will end up with a warmer climate than we want,” he said.

“If we start cutting emissions now, we will slow down the thaw rate and push the start of this carbon release off into the future,” Schaefer says, trying to not paint a completely dark future.

University of Florida ecology professor Ted Schuur used a different method to study the effect of thawing permafrost on atmospheric carbon in a 2009 study and arrived at the same annual figure for carbon entering the atmosphere as Schaefer and his co-authors.

The loss of permafrost would not present a significant threat to the planet, some have argued, as plants would start to grow on the warmer earth and suck in carbon dioxide from the atmosphere through photosynthesis, thus negating the issue.

Schuur however, said in his study two years ago that protection from plant growth “doesn’t last, because there is so much carbon in the permafrost that eventually the plants can’t keep up.” Schaefer insisted that a major preventive effort, starting now, could stave off the worst-case scenario of the  release of the huge amounts of CO2 into the atmosphere ,further accelerating global warming and permafrost melting.

Image Caption: The image was taken in High Arctic from a helicopter. It shows the crack pattern in permafrost. Credit: Mila Zinkova/Wikipedia (CC BY-SA 3.0)

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Thawing Permafrost Likely Will Accelerate Global Warming In Coming Decades

Up to two-thirds of Earth’s permafrost likely will disappear by 2200 as a result of warming temperatures, unleashing vast quantities of carbon into the atmosphere, says a new study by the University of Colorado Boulder’s Cooperative Institute for Research in Environmental Sciences.

The carbon resides in permanently frozen ground that is beginning to thaw in high latitudes from warming temperatures, which will impact not only the climate but also international strategies to reduce fossil fuel emissions, said CU-Boulder’s Kevin Schaefer, lead study author. “If we want to hit a target carbon dioxide concentration, then we have to reduce fossil fuel emissions that much lower than previously thought to account for this additional carbon from the permafrost,” he said. “Otherwise we will end up with a warmer Earth than we want.”

The escaping carbon comes from plant material, primarily roots trapped and frozen in soil during the last glacial period that ended roughly 12,000 years ago, he said. Schaefer, a research associate at CU-Boulder’s National Snow and Ice Data Center, an arm of CIRES, likened the mechanism to storing broccoli in a home freezer. “As long as it stays frozen, it stays stable for many years,” he said. “But if you take it out of the freezer it will thaw out and decay.”

While other studies have shown carbon has begun to leak out of permafrost in Alaska and Siberia, the study by Schaefer and his colleagues is the first to make actual estimates of future carbon release from permafrost. “This gives us a starting point, and something more solid to work from in future studies,” he said. “We now have some estimated numbers and dates to work with.”

The new study was published online Feb. 14 in the scientific journal Tellus. Co-authors include CIRES Fellow and Senior Research Scientist Tingjun Zhang from NSIDC, Lori Bruhwiler of the National Oceanic and Atmospheric Administration and Andrew Barrett from NSIDC. Funding for the project came from NASA, NOAA and the National Science Foundation.

Schaefer and his team ran multiple Arctic simulations assuming different rates of temperature increases to forecast how much carbon may be released globally from permafrost in the next two centuries. They estimate a release of roughly 190 billion tons of carbon, most of it in the next 100 years. The team used Intergovernmental Panel on Climate Change scenarios and land-surface models for the study.

“The amount we expect to be released by permafrost is equivalent to half of the amount of carbon released since the dawn of the Industrial Age,” said Schaefer. The amount of carbon predicted for release between now and 2200 is about one-fifth of the total amount of carbon in the atmosphere today, according to the study.

While there were about 280 parts per million of CO2 in Earth’s atmosphere prior to the Industrial Age beginning about 1820, there are more than 380 parts per million of carbon now in the atmosphere and the figure is rising. The increase, equivalent to about 435 billion tons of carbon, resulted primarily from human activities like the burning of fossil fuels and deforestation.

Using data from all climate simulations, the team estimated that about 30 to 60 percent of Earth’s permafrost will disappear by 2200. The study took into account all of the permanently frozen ground at high latitudes around the globe.

The consensus of the vast majority of climate scientists is that the buildup of CO2 and other greenhouse gases in Earth’s atmosphere is the primary reason for increasingly warm temperatures on Earth. According to NOAA, 2010 was tied for the hottest year on record. The hottest decade on record occurred from 2000 to 2010.

Greater reductions in fossil fuel emissions to account for carbon released by the permafrost will be a daunting global challenge, Schaefer said. “The problem is getting more and more difficult all the time,” he said. “It is hard enough to reduce the emissions in any case, but now we have to reduce emissions even more. We think it is important to get that message out now.”

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Study Reveals Security Weaknesses In File-Sharing Methods Used In Clinical Trials

Patients who participate in clinical trials expect that their personal information will remain confidential, but a recent study led by Dr. Khaled El-Emam, Canada Research Chair in Electronic Health Information at the CHEO Research Institute, found that the security practices used to transfer and share sensitive files were inadequate.

The two-part study, entitled “How Strong Are Passwords Used to Protect Personal Health Information in Clinical Trials?”, published today in the Journal of Medical Internet Research, showed that the majority of passwords used to protect files are poorly constructed and easily cracked using commercial password recovery tools. Study coordinator interviews indicated that electronic information shared in the context of clinical trials may put personal health information at risk.

“The patients in these trials expect that their personal information will be protected,” said Dr. El-Emam. “This is critical for maintaining the trust of clinical trial participants, and the public in general.”

In the course of the study, passwords for 14 out of 15 sensitive files transmitted by email were successfully decoded. Of these 14, 13 contained sensitive health information and other potentially identifying factors such as name of study site, dates of birth, initials, and gender. File sharing practices were also found to be insecure, with unencrypted patient information being shared via email and posted on shared drives with common passwords.

“Cracking the passwords proved to be trivial,” said Dr. El-Emam. “Choices included passwords as simple as car makers (e.g., “nissan”), and common number sequences (e.g., “123”). It was easy for the password recovery tools to guess them.”

Poor security practices can be harmful to patients participating in clinical trials, who are at risk of being identified and possibly stigmatized by the disclosure of personal health information. There is also a potential for both medical and non-medical identity theft. In the context of international clinical trials, inadvertent disclosure of personal health information is considered a data breach in countries like the United States, which can lead to penalties in some states.

Dr. El-Emam believes that with some effort file sharing in clinical trials can be made secure: “There are protocols and tools that can be employed for secure file sharing. It may take more effort on the part of those who conduct clinical trials, but the alternative would not be acceptable.”

Dr. El-Emam makes several recommendations, including enforcement of strong passwords and encryption algorithms, encrypting all information sent via email including site queries, and minimizing password sharing.

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Typical Novel Object Recognition

This movie shows a typical (wild type) mouse as it spends much more time exploring an object it has never seen before and little time with the object it has previously explored. In this study, the mice without the WRP gene spent equal amounts of time exploring new and already seen objects.

Credit: Duke University Medical Center, Dept. of Cell Biology

Abnormal Hand Control Movements Could Show ADHD In Children

Measurements of hand movement control may help determine the severity of attention deficit hyperactivity disorder (ADHD) in children, according to joint studies published in the February 15, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology. ADHD is a brain disorder characterized by impulsiveness, hyperactivity, such as not being able to sit still, and inattention or difficulty staying focused.

The studies were led by Stewart H. Mostofsky, MD, with the Kennedy Krieger Institute in Baltimore and Donald L. Gilbert, MD, MS, with Cincinnati Children’s Hospital Medical Center in Cincinnati.

For the first study, researchers examined mirror overflow movements in 25 boys and girls between the ages of eight and 13 with ADHD and 25 boys and girls without the disorder. Mirror movements are characterized by the inability to move one side of the body without moving the other. All children were right-handed. Using video and a device that recorded finger position, the researchers measured differences in how the children tapped their fingers.

The children with ADHD experienced more mirror movements than the children without ADHD. During left-handed finger tapping, children with ADHD showed more than twice as much mirror overflow than children without ADHD. The differences were particularly prominent for boys with ADHD, who showed nearly four times as much mirror overflow than boys without ADHD on one of the two measures used in the study.

In the second study, scientists applied transcranial magnetic stimulation (TMS) to the motor control area of the brain in 49 children with ADHD and 49 children without ADHD, all right-handed and ages 8 to 12. TMS technology allows scientists to activate brain cells with magnetic pulses in order to measure brain activity.

The study found that the brain’s short-interval cortical inhibition (SICI), which is an important “braking mechanism” in the brain, was reduced by 40 percent in children with ADHD compared to those without the disorder. On motor development tests, those with ADHD scored nearly 60 percent worse compared to those children without ADHD. Importantly, the scientists also found that the amount of reduced inhibition in the motor area of the brain was strongly associated with the severity of ADHD symptoms reported by the parents.

“These studies are an important step toward understanding how ADHD affects communication between the brain and other parts of the body,” said Jonathan W. Mink, MD, PhD, with the University of Rochester Medical Center in New York in an accompanying editorial. Mink is also an associate editor of Neurology. “These findings show that mirror movements are likely a marker of abnormal development of motor control that improves with age and is more prominent in boys. They also provide a more specific way to measure ADHD. The hope is that, ultimately, these studies and others will guide us toward development and testing of new therapies.”

The studies were supported by the National Institutes of Health.

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Street Drugs and Stroke

(Ivanhoe Newswire) — Crack, cocaine, marijuana “¦ we all know that illegal drugs are bad for your health, but a new study suggests they could also increase your risks of having a stroke.

A new study from the University of Cincinnati found that illegal drug use among stroke patients rose more than nine-fold, over a 13 year period.
Researchers say this increase in recreational drug use could explain why they’re starting to see more strokes in younger patients.

“We know that stroke incidence in younger age groups has increased over time in our region,” says De los Rios, referring to UC research presented at last year’s International Stroke Conference. “With street drug use more prevalent at younger ages, this could help explain that phenomenon.”

During the 13-year study researchers found current smoking and heavy alcohol use remained relatively stable, while street drug use including marijuana and cocaine/crack rose about four percent.

Illegal drug use information came from patients’ charts or positive urine and blood tests. Current smoking was defined as present within the past three months; heavy alcohol use constituted three or more servings per day.

Some drugs can cause stroke by affecting blood vessels in the brain, or by affecting other organs in the body such as the heart or the liver. A study published in the Western Journal of Medicine found a clear connection between cocaine use and stroke. Cocaine causes a narrowing of the blood vessels. This can cut off blood flow to parts of the brain, kill brain tissue, and produce an ischemic stroke. Street drugs overall increase blood pressure and high high blood pressure is the number one risk factor for stroke.

SOURCE: University of Cincinnati, February 14, 2011

Researchers Working Toward Automating Sedation In Intensive Care Units

Computer system for evaluating sedation level shows strong agreement with clinical assessment

Researchers at the Georgia Institute of Technology and the Northeast Georgia Medical Center are one step closer to their goal of automating the management of sedation in hospital intensive care units (ICUs). They have developed control algorithms that use clinical data to accurately determine a patient’s level of sedation and can notify medical staff if there is a change in the level.

“ICU nurses have one of the most task-laden jobs in medicine and typically take care of multiple patients at the same time, so if we can use control system technology to automate the task of sedation, patient safety will be enhanced and drug delivery will improve in the ICU,” said James Bailey, the chief medical informatics officer at the Northeast Georgia Medical Center in Gainesville, Ga. Bailey is also a certified anesthesiologist and intensive care specialist.

During a presentation at the IEEE Conference on Decision and Control, the researchers reported on their analysis of more than 15,000 clinical measurements from 366 ICU patients they classified as “agitated” or “not agitated.” Agitation is a measure of the level of patient sedation. The algorithm returned the same results as the assessment by hospital staff 92 percent of the time.

“Manual sedation control can be tedious, imprecise, time-consuming and sometimes of poor quality, depending on the skills and judgment of the ICU nurse,” said Wassim Haddad, a professor in the Georgia Tech School of Aerospace Engineering. “Ultimately, we envision an automated system in which the ICU nurse evaluates the ICU patient, enters the patient’s sedation level into a controller, which then adjusts the sedative dosing regimen to maintain sedation at the desired level by continuously collecting and analyzing quantitative clinical data on the patient.”

This project is supported in part by the U.S. Army. On the battlefield, military physicians sometimes face demanding critical care situations and the use of advanced control technologies is essential for extending the capabilities of the health care system to handle large numbers of injured soldiers.

Working with Haddad and Bailey on this project are Allen Tannenbaum and Behnood Gholami. Tannenbaum holds a joint appointment as the Julian Hightower Chair in the Georgia Tech School of Electrical and Computer Engineering and the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, while Gholami is currently a postdoctoral fellow in the Georgia Tech School of Electrical and Computer Engineering.

This research builds on Haddad and Bailey’s previous work automating anesthesia in hospital operating rooms. The adaptive control algorithms developed by Haddad and Bailey control the infusion of an anesthetic drug agent in order to maintain a desired constant level of depth of anesthesia during surgery in the operating room. Clinical trial results that will be published in the March issue of the journal IEEE Transactions on Control Systems Technology demonstrate excellent regulation of unconsciousness allowing for a safe and effective administration of an anesthetic agent.

Critically ill patients in the ICU frequently require invasive monitoring and other support that can lead to anxiety, agitation and pain. Sedation is essential for the comfort and safety of these patients.

“The challenge in developing closed-loop control systems for sedating critically ill patients is finding the appropriate performance variable or variables that measure the level of sedation of a patient, in turn allowing an automated controller to provide adequate sedation without oversedation,” said Gholami.

In the ICU, the researchers used information detailing each patient’s facial expression, gross motor movement, response to a potentially noxious stimulus, heart rate and blood pressure stability, noncardiac sympathetic stability, and nonverbal pain scale to determine a level of sedation.

The researchers classified the clinical data for each variable into categories. For example, a patient’s facial expression was categorized as “relaxed,” “grimacing and moaning,” or “grimacing and crying.” A patient’s noncardiac sympathetic stability was classified as “warm and dry skin,” “flushed and sweaty,” or “pale and sweaty.”

They also recorded each patient’s score on the motor activity and assessment scale (MAAS), which is used by clinicians to evaluate level of sedation on a scale of zero to six. In the MAAS system, a score of zero represents an “unresponsive patient,” three represents a “calm and cooperative patient,” and six represents a “dangerously agitated patient.” The MAAS score is subjective and can result in inconsistencies and variability in sedation administration.

Using a Bayesian network, the researchers used the clinical data to compute the probability that a patient was agitated. Twelve-thousand measurements collected from patients admitted to the ICU at the Northeast Georgia Medical Center between during a one-year period were used to train the Bayesian network and the remaining 3,000 were used to test it.

In 18 percent of the test cases, the computer classified a patient as “agitated” but the MAAS score described the same patient as “not agitated.” In five percent of the test cases, the computer classified a patient as “not agitated,” whereas the MAAS score indicated “agitated.” These probabilities signify an 18 percent false-positive rate and a five percent false-negative rate.

“This level of performance would allow a significant reduction in the workload of the intensive care unit nurse, but it would in no way replace the nurse as the ultimate judge of the adequacy of sedation,” said Bailey. “However, by relieving the nurse of some of the work associated with titration of sedation, it would allow the nurse to better focus on other aspects of his or her demanding job.”

The researchers’ next step toward closed-loop control of sedation in the ICU will be to continuously collect clinical data from ICU patients in real time. Future work will involve the development of objective techniques for assessing ICU sedation using movement, facial expression and responsiveness to stimuli.

Digital imaging will be used to assess a patient’s facial expression and also gross motor movement. In a study published in the June 2010 issue of the journal IEEE Transactions on Biomedical Engineering, the researchers showed that machine learning methods could be used to assess the level of pain in patients using facial expressions.

“We will explore the relationship between the data we can extract from these multiple sensors and the subjective clinical MAAS score,” said Haddad. “We will then use the knowledge we have gained in developing feedback control algorithms for anesthesia dosage levels in the operating room to develop an expert system to automate drug dosage in the ICU.”

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Study Questions Safety, Effectiveness Of Energy Drinks

Energy drinks such as Red Bull and Full Throttle apparently do not benefit consumers the way that they claim to, and could be harmful to younger children, according to the findings of a new study published online in the journal Pediatrics on Monday.

In their study, University of Miami Leonard M. Miller School of Medicine Chair of Pediatrics Steven Lipshultz and his colleagues reviewed more than 120 different scientific studies, government reports, and media sources regarding energy drinks, USA Today reporter Nanci Hellmich said in an article.

Even though 30% to 50% of teenagers and adults consume such products, Lipshultz told Hellmich that his team “didn’t see evidence that drinks have beneficial effects in improving energy, weight loss, stamina, athletic performance and concentration.”

Furthermore, according to Nicole Ostrow of Bloomberg, “Some of the ingredients in the drinks are understudied and not regulated”¦ [and] children with diabetes, mood disorders and heart, kidney or liver diseases may have reactions including heart palpitations, seizures, cardiac arrest or even death, the authors said.”

Judith Schaechter, study author and associate professor of pediatrics at the University of Miami, told Ostrow that roughly one-third of kids between the ages of 12 and 14 consume these energy drinks, which contain caffeine and sugar, among other ingredients. Schechter and her co-authors also said that 46% of the individuals who overdosed on caffeine in the US in 2007 were under the age of 19.

“Pediatricians need to be aware of the possible effects of energy drinks,” Lipshultz told Ostrow in a February 11 email. “Toxicity surveillance should be improved and regulations of energy-drink sales and consumption should be based on appropriate research assessing energy drink safety.”

Likewise, he told Hellmich that research has shown that children and teenagers are more likely to suffer health complications from these beverages, especially if they suffer from cardiovascular, renal or liver disease, seizures, diabetes, mood and behavior disorders and/or hyperthyroidism.

Officials from the beverage industry have taken issue with the study.

In a statement cited by USA Today, Maureen Storey of the American Beverage Association said that the University of Miami report “does nothing more than perpetuate misinformation about energy drinks, their ingredients and the regulatory process,” and that government data has indicated that “caffeine consumed from energy drinks for those under the age of 18 is less than the caffeine derived from all other sources including soft drinks, coffee and teas.”

Patrice Radden, a spokeswoman for Red Bull, told Bloomberg that their product “is available in over 160 countries because health authorities across the world have concluded that Red Bull Energy Drink is safe to consume”¦ Last year alone, over 4 billion cans and bottles were consumed across the world.”

In a separate statement quoted from by USA Today, officials from the energy drink manufacturer added that the study “largely ignores in its conclusions the genuine, scientifically rigorous examination of energy drinks by reputable national authorities. … The effects of caffeine are well-known, and as an 8.4-oz. can of Red Bull contains about the same amount of caffeine as a cup of coffee (80 milligrams), it should be treated accordingly.”

Ostrow attempted to contact officials at California-based Hansen’s Natural, the manufacturers of the Monster Energy drink, but spoke to an individual who would not identify herself and declined to comment on the study.

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Kenya Elephant Census Shows Slow Growth

The elephant population in Kenya’s expansive Kenya’s Tsavo National Park, in the south of the country, rose to 12,572 from 11,696 three years ago according to the preliminary results of a census released Saturday.

AFP reports that despite increased poaching and a recent severe drought, Kenya is pleased to announce the rise in elephant population in its flagship park, wildlife authorities announced.

Tsavo National Park is Kenya’s premier elephant sanctuary, hosting one third of its entire elephant population and covers 46,437 square kilometers of territory, an area bigger than Denmark and more than twice the size of Israel. Tsavo is also the pulse of the status of Kenya’s endangered elephants.

With more than 100 participants from four countries aimed at establishing the populations, trends and distribution of elephants, the census will assist policy makers and the wildlife authorities make sound conservation policy and management decisions for the ecosystem.

The count represents an increase of around two percent, lower, however, than the four percent rise that has been recorded in previous counts. “This has happened in the backdrop of a very bad drought,” said Julius Kipng’etich, the director of the Kenya Wildlife Service. “The new numbers might also reflect the increased demand for ivory and the subsequent rise in poaching,” he tells AFP.

Commenting on the exercise of the Kenyan Wildlife Service (KWS), James Isiche, East Africa regional director for the International Fund for Animal Welfare (IFAW) said, “It is our responsibility to continuously establish and monitor elephant populations, trends and distribution to enhance their protection. We must all join efforts to ensure that elephants are not wiped out from the face of the earth.”

“While this census is integral to the conservation and management of elephants, the real challenge remains protecting them from threats such as poaching and challenges brought forth by land-use changes,” added Isiche.

IFAW has been undertaking a partnership project in Tsavo with the KWS since 2005, to enhance management operations in law enforcement and anti-poaching efforts, park infrastructural support, human-wildlife conflict mitigation and resolution, community conservation initiatives, research and education.

Conservationist Iain Douglas-Hamilton, the founder of Save the Elephants organization tells AFP the latest figures were “hugely significant not only for Kenya but for Africa.”

In recent months, Kenyan authorities have arrested several people trafficking ivory through its main airport in Nairobi, mainly to Asian countries where the tusks are used in traditional medicines and ornaments.

Isiche concluded by telling AFP, “Whilst this census is integral to the conservation and management of elephants, the real challenge remains in protecting them from threats such as poaching and challenges brought forth by land use changes.”

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New Gene Test Discovered For Inherited Neuromuscular Disorder

Newcastle University scientists have identified a new gene which will allow rapid diagnosis and earlier treatment of a debilitating neuromuscular condition.

The gene, GFPT1, is crucial in causing a variation of Congenital Myasthenic Syndrome (CMS) which gained media attention recently with the plight of baby RB, who was at the centre of a “right-to-life” legal dispute.

CMS is a rare genetic condition affecting the way signals travel between the brain and muscles which can cause paralysis and in some cases death. It affects one in every 500,000 births and the severity of the condition varies, depending on where the fault lies in the complex signals between the nerves and the muscles.

The variation of CMS identified by the team of international researchers, GFPT1, tends to develop in the first ten years of life with patients losing muscle strength and control in their hips and shoulders or arms and legs.

“The identification of this gene means that doctors can order genetic analysis and confirm the condition allowing earlier treatment with cholinesterase inhibitors,” explained Professor Hanns Lochmller of the Institute of Human Genetics at Newcastle University.

“This offers an effective therapy which can be taken through life,” he added.

The research also highlighted a new area to explore for future treatments as GFPT1 is involved in initiating the metabolism of amino sugar.

The international team, headed up by Dr. Jan Senderek from the University of Aachen in Germany and by Dr Juliane Mller from Newcastle University, analysed the genes of 13 families affected by the condition.

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Recovered Fossil Reveals ‘Lucy’ Walked Upright

A fossilized arched foot bone recovered from Ethiopia shows that our human ancestors walked upright 3.2 million years ago, according to a study published Thursday in the journal Science.

The fossil, a fourth metatarsal, or midfoot bone, belongs to a group of the famed hominid Lucy, and indicates that a permanently arched foot was present in the species Australopithecus afarensis.  The findings are the first evidence to address the question of how this species moved around.

“This fourth metatarsal is the only one known of A. afarensis and is a key piece of evidence for the early evolution of the uniquely human way of walking,” said study co-author William Kimbel of Arizona State University.

The research helps resolve a long-standing debate between paleoanthropologists who believe A. afarensis walked essentially the same as modern-day humans and those who believe the species practiced a form of locomotion intermediate between the quadrupedal tree climbing of chimpanzees and human terrestrial bipedalism.

The question of whether A. afarensis had fully developed pedal, or foot, arches has also been part of this debate. The fourth metatarsal described in the study provides strong evidence for the arches and supports a modern-human style of locomotion for this species.

The fossil was recovered from the Hadar locality 333, often referred to as the “First Family Site”.  The area is the richest source of A. afarensis fossils in eastern Africa, with more than 250 specimens representing at least 17 individuals.

“This fourth metatarsal is the only one known of A. afarensis and is a key piece of evidence for the early evolution of the uniquely human way of walking,” said Kimbel.

“The ongoing work at Hadar is producing rare parts of the skeleton that are absolutely critical for understanding how our species evolved.”

Humans are unique among primates in having two arches in their feet — longitudinal and transverse.  These arches are composed of the midfoot bones and supported by muscles in the sole of the foot. 

During bipedal locomotion, these arches perform two vital functions: leverage when the foot pushes off the ground and shock absorption when the sole of the foot meets the ground at the completion of the stride.

By contrast, ape feet lack permanent arches, are more flexible than human feet and have a highly mobile large toe.  These attributes facilitate climbing and grasping in the trees.  However, none of these apelike features are present in the foot of A. afarensis.

“Understanding that the foot arches appeared very early in our evolution shows that the unique structure of our feet is fundamental to human locomotion,” said Carol Ward of the University of Missouri, a co-author of the report.

“If we can understand what we were designed to do and how natural selection shaped the human skeleton, we can gain insight into how our skeletons work today. Arches in our feet were just as important for our ancestors as they are for us.”

A.afarensis lived in eastern Africa between 3.7 and 2.9 million years ago, and its most famous specimen is “Lucy.”

Prior to A. afarensis, the species A. anamensis was present in Kenya and Ethiopia from 4.2 to 4.0 million years ago, although its skeleton is not well known. At 4.4 million years ago, Ethiopia’s Ardipithecus ramidus is the earliest human ancestor well represented by skeletal remains.  However, it appears to have been a part-time terrestrial biped, whose foot retained many features of tree-dwelling primates, including a divergent, mobile first toe.

The foot of A. afarensis, as with other parts of its skeleton, is much more like that of living humans, implying that by the time of Lucy, our ancestors no longer depended on the trees for refuge or resources.

Commenting on the study, Professor Chris Stringer, a paleoanthropologist at London’s Natural History Museum, said scientists were slowly filling in the detail of Lucy’s place in human history.

“Bipedalism in Lucy is established, but there has been an issue about how much like our own that bipedalism was,” he told BBC News.

“Was it a more waddling gait or something more developed?

“And certainly there’s evidence in the upper body that the Australopithecines still seemed to have climbing adaptations – so, the hand bones are still quite strongly curved and their arms suggest they’re still spending time in the trees.

“If you are on the ground all the time, you need to find shelter at night and you are in a position to move out into open countryside, which has implications for new resources – scavenging and meat-eating, for example.

“If the Australopithecines were on that road, they were only at the very, very beginning of it.”

Image 1: This is the fossilized foot bone — fourth metatarsal of Australopithecus afarensis (AL 333-160) — recovered from Hadar, Ethiopia. Credit: Elizabeth Harmon/Arizona State University

Image 2: This image shows the position of the fourth metatarsal Australopithecus afarensis (AL 333-160) recovered from Hadar, Ethiopia, in a foot skeleton. Credit: Carol Ward/University of Missouri

Image 3: Paleoanthropologists report in the Feb. 10 edition of Science on the recovery of a fossilized foot bone recovered from Hadar, Ethiopia, locality 333, popularly known as the “First Family Site,” the richest source of Australopithecus afarensis fossils in eastern Africa. Credit: Donald Johanson/Institute of Human Origins/Arizona State University

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Exercise Helps Overweight Kids Think, Perform Better

Regular exercise improves the ability of overweight, previously inactive children to think, plan and even do math, Georgia Health Sciences University researchers report.

They hope the findings in 171 overweight 7- to 11-year-olds ““ all sedentary when the study started – gives educators the evidence they need to ensure that regular, vigorous physical activity is a part of every school day, said Dr. Catherine Davis, clinical health psychologist at GHSU’s Georgia Prevention Institute and corresponding author on the study in Health Psychology

“I hope these findings will help reestablish physical activity’s important place in the schools in helping kids stay physically well and mentally sharp,” Davis said. “For children to reach their potential, they need to be active.”

To measure cognition, researchers used the Cognitive Assessment System and Woodcock-Johnson Tests of Achievement III that measure abilities such as planning and academic skills such as math and reading. A subset of the children received functional magnetic resonance imaging highlighting increased or decreased areas of brain activity.

MRIs showed those who exercised experienced increased brain activity in the prefrontal cortex ““ an area associated with complex thinking, decision making and correct social behavior – and decreased activity in an area of the brain that sits behind it. The shift forward appears consistent with more rapidly developing cognitive skills, Davis said.

And the more they exercised, the better the result. Intelligence scores increased an average 3.8 points in those exercising 40 minutes per day after school for three months with a smaller benefit in those exercising 20 minutes daily.

Activity in the part of their brain responsible for so-called executive function also increased in children who exercised. “In kids you just don’t know what impact you are going to have when you improve their ability to control their attention, to behave better in school, to make better choices,” Davis notes. “Maybe they will be more likely to stay in school and out of trouble.”

Similar improvements were seen in math skills; interestingly, no improvements were found in reading skill. Researchers note that improved math achievement was “remarkable” since no math lessons were given and suggests longer intervention could produce even better results.

Children in the exercise program played hard, with running games, hula hoops and jump ropes, raising their heart rates to 79 percent of maximum, which is considered vigorous.

Cognitive improvements likely resulted from the brain stimulation that came from movement rather than resulting cardiovascular improvements, such as increased blood and oxygen supplies, Davis said. “You cannot move your body without your brain.”

The researchers hypothesize that such vigorous physical activity promotes development of brain systems that underlie cognition and behavior. Animal studies have shown that aerobic activity increases growth factors so the brain gets more blood vessels, more neurons and more connections between neurons. Studies in older adults have shown exercise benefits the brain and Davis’s study extends the science to children and their ability to learn in school.

About one-third of U.S. children are overweight. Davis suspects exercise would have a similar impact on their leaner counterparts.

Co-authors include Dr. Jennifer E. McDowell, neuroscientist, and Dr. Phillip Dr. Tomporowski, exercise and cognition expert, at the University of Georgia.

Image Caption: Regular exercise improves thinking and planning ability of overweight, previously inactive children, Georgia Health Sciences University researchers report. Credit: Phil Jones/GHSU

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Researchers Pique Girls’ Interest In Computing Science

A joint research project between the University of Alberta’s Faculty of Education and the Department of Computing Science has found that, for high-school girls, the fun is in making video games, not just playing them.

Computing science professor Duane Szafron and fellow U of A researchers Mike Carbonaro, Jonathan Schaeffer and Maria Cutumisu say that women in computing science are rare, but their study shows that if you want to get more females interested in computing science, you have to rewrite the program, so to speak.

“There’s been a huge push throughout North America to try and get girls to go into computing science, but [educators are] having a lot of challenges convincing them,” said the Faculty of Education’s Carbonaro. “The findings are important, as they demonstrate a way to motivate girls’ interest in computing science”

In their study, the researchers wanted to see whether girls would gain as much interest in game development as they boys in the class control group. To facilitate the experiment, they introduced a group of local Grade 10 students to a program called ScriptEase, a tool that allowed them to develop and design their own games. A key factor in the study was having male participants who had more experience than the females in gaming.

Szafron says that there is an inherent creative component to computing science, and that having a student design and construct something using the tool is one way to allow them to investigate that aspect of computing science. “We thought we should have female students create games and see if they are just as excited about making games as male students and see whether it’s an attractor to computing science that is independent of gender,” he said.

Their findings indicated that female students enjoyed creating games as much as their male counterparts; further, they preferred game construction to activities such as story writing. Further, he noted the female students gained and used practical skills that are crucial to understanding computing science.

“The female students built games that were every bit as good as the male students made, even though the male students had more experience with playing games,” said Szafron. “In terms of the quality of the games developed and the abstraction skills that the students learned, which could translate to knowledge of competing science””and in terms of the amount of fun that they had””there was no difference between the two groups.”

According to Carbonaro, computing science teachers need to look at redesigning the types of projects and content they use in class to make them more “female-user friendly.”

“If you want more females in computing science, you need to radically change the curriculum. You need to provide activities that are more gender neutral so that they’ll be attracted to the discipline.”

The research study was recently published in Computers and Education.

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Robot Information Sharing Website In The Works

European scientists have launched a new website that robots will use to share data and ask for assistance in completing a certain project, according to a Wednesday report by BBC News Technology Correspondent Mark Ward.

Ward compares the website, which is being called RoboEarth, to a robotic equivalent of Wikipedia, and says that the project will “let robots share and store what they discover about the world.”

“It will be a place that robots can upload data to when they master a task, and ask for help in carrying out new ones,” the BBC News reporter added. “Researchers behind it hope it will allow robots to come into service more quickly, armed with a growing library of knowledge about their human masters.”

RoboEarth will serve as both a system of communication and a database of information, Dr. Markus Waibel of the Swiss Federal Institute of Technology, one of the researchers behind the website, told Ward. He said that he hopes it will eventually allow robots to share information that they discover about the word so that any other robot in the world can find it and utilize it.

Some examples of the types of information Waibel and his team of nearly three dozen colleagues anticipate being shared through RoboEarth are maps of locations where the robots work, descriptions of the various objects they encounter, and even detail sets of instructions for completing specific activities.

The robots themselves would contribute and edit the information, thus leading to the Wikipedia comparisons.

“Wikipedia is something that humans use to share knowledge, that everyone can edit, contribute knowledge to and access. Something like that does not exist for robots,” Waibel told Ward. “The key is allowing robots to share knowledge. That’s really new.”

“Dr. Waibel said it would be a place that would teach robots about the objects that fill the human world and their relationships to each other,” Ward added. “For instance, he said, RoboEarth could help a robot understand what is meant when it is asked to set the table and what objects are required for that task to be completed.”

The project is funded by the European Union (EU), according to BBC News, and preliminary work has led to the development of a method in which robots can upload maps and download a series of instructions for tasks that they can complete. They hope that the project will be fully operational within four years.

“Bringing a new meaning to the phrase ‘experience is the best teacher’, the goal of RoboEarth is to allow robotic systems to benefit from the experience of other robots, paving the way for rapid advances in machine cognition and behavior, and ultimately, for more subtle and sophisticated human-machine interaction,” claims a statement on the project’s official website.

“RoboEarth will include everything needed to close the loop from robot to RoboEarth to robot,” the RoboEarth homepage adds. “The RoboEarth World-Wide-Web style database will be implemented on a Server with Internet and Intranet functionality. It stores information required for object recognition (e.g., images, object models), navigation (e.g., maps, world models), tasks (e.g., action recipes, manipulation strategies) and hosts intelligent services (e.g., image annotation, offline learning).”

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Chicago Residents Concerned Over Surveillance Cameras

High-tech surveillance cameras in use around Chicago used by the city’s police to zoom in on crimes in progress and track suspects across the city are the subject of growing privacy concerns from citizens and privacy rights activists.

Chicago has been on a path since 2003 to become the country’s most-watched city, when police first started installing security cameras in high-crime areas around the city. Since the onset of the program, Chicago has linked up more than 10,000 public and privately owned surveillance cams in a system dubbed Operation Virtual Shield, according to a report by the American Civil Liberties Union.

The report, published Tuesday, states that at least 1,250 of those cams are powerful enough to zoom in and read the text of a book, and is also capable of automatically tracking people and vehicles out of range of one camera and into another.

“Given Chicago’s history of unlawful political surveillance, including the notorious ‘Red Squad,’ it is critical that appropriate controls be put in place to rein in these powerful and pervasive surveillance cameras now available to law enforcement throughout the City,” Harvey Grossman, legal director of the ACLU of Illinois, told AFP.

The “Red Squad” program, run by the Chicago police from the 20s to the 70s, was used to spy on and maintain profiles of thousands of individuals and groups in an effort to find communists and other insubordinates.

Richard Daley, the outgoing mayor of Chicago, has long supported the surveillance cameras as crime-fighting tools and said he would like to see them on every street corner.

The Chicago police said the cameras have led to 4,500 arrests in the past four years.

But the ACLU said the price tag that comes with the high-tech surveillance system could be better spent on the 1,000+ vacancies in the Chicago police force.

It urged city officials to impose a ban on new cameras and implement new policies to prevent the misuse of the cameras, such as prohibiting filming of private residencies and limiting the propagation of recorded images.

“Our city needs to change course, before we awake to find that we cannot walk into a book store or a doctor’s office free from the government’s watchful eye,” said the ACLU.

A spokeswoman with the Chicago police department said the force regularly reviews it policies and keeps an “open dialogue” with the ACLU.

“The Chicago Police Department is committed to safeguarding the civil liberties of city residents and visitors alike,” Lieutenant Maureen Biggane told the French news agency in an e-mail. “Public safety is a responsibility of paramount importance and we are fully committed to protecting the public from crime, and upholding the constitutional rights of all.”

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EBooks Threaten Brick-And-Mortar Book Stores

Analysts see a struggle for survival by traditional booksellers thanks to a growing shift to electronic books and Internet sales.

Borders Group said in late January it would delay payments to vendors, landlords and others as it seeks to restructure its debt, but many analysts see bankruptcy or a sale looming for the second-largest U.S. bookseller.

Barnes & Noble said last year that it was in discussions of a sale or other strategic options.

“Disruptive change is coming to the book businesses of the world and they’re looking to the US experience to understand the nature of that change and what to do to prepare for it,” Mike Shatzkin, head of the consultancy Idea Logical Company and organizer of the Digital Book World conference held recently in New York, told AFP.

According to Shatzkin, ebook sales have more than doubled in each of the last three years.

He said he sees the market for traditional booksellers tumbling from 72 percent of the sales to about 25 percent of the sales.

He told AFP in an email that this would mean a loss of 90 percent of bookstore shelf space over the next 10 years, and a drop from over 1,200 large bookstores in the U.S. to “maybe 150 decent-sized stores.”

Amazon.com said last month that it is now selling more Kindle books than paperback books in the U.S. market.

“Bookstores lose customers two ways: to e-book sales and to print (books) sold online,” Shatzkin told AFP’s Rob Lever. “Print online is now about 25 percent of print sales and e-book sales are about 10 percent of print sales.”

A Pew Research Center report found that five percent of Americans owned an ebook reader last year, but that may underestimate the trend because other devices like smartphones can be used for the same purpose.

Forrester Research said Americans spent $1 billion more on ebook downloads in 2010 than in 2009 and the market is surging.

Forrester’s James McQuivey told Lever that an estimated seven percent of Americans read ebooks and that “this small, energetic group will grow so rapidly that it will easily spend nearly $3 billion on e-books in 2015.”

Analysts said the lower cost and convenience of getting electronic books instantly has threatened big book chains.

“The traditional bookstore is doomed by e-readers and online sales of hard copy books,” Nobel laureate economist Gary Becker said in a blog post, describing a type of shift economists call “creative destruction”, like replacing horse-drawn wagons with automobiles.

He said he still sees bookstores, but mainly to serve particular market niches.

Billy Hulkower, senior technology analyst at the research firm Mintel, told AFP that bookstores face a “trilogy of threats,” including online competition, ebooks, and public libraries offering free books and digital content.

“Retailers need to focus on creating compelling reasons for patrons to visit bookstores, like concierge or recommendation services,” he said.

Laurie Brock, president of the consultancy Brock Associates, told AFP that a recent survey by her firm shows consumers increasingly like their reading devices.

Brock said that in many cases, ebooks are sold to “avid readers” who want more to read.

For now, ebooks are less expensive than printed books, but the lower cost shakes up the economics of the entire industry.

“If people are only going to be reading ebooks, are publishers going to be able to keep them at the lower price point?” Brock asked. “Probably not, but Amazon has set the price low, and that’s where the big debate is going now.”

Shatzkin told AFP that the economics of the industry are being turned upside down by the digital revolution.

“Yes, it will be harder to make money,” he said. “The prices of books will continue to fall. It will be easier to get published — anybody will be able to do it — but it will be damn tough to make much money at it.”

He also said book merchants around the world will also soon feel the impact.

“The rest of the world isn’t so noticeable yet, but we all expect they will begin to very soon,” Shatzkin said.

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Language May Play Key Role In Learning Number Meanings

Research shows “homesigners” unable to comprehend the value of large numbers

New research conducted with deaf people in Nicaragua shows that language may play an important role in learning the meanings of numbers.

Field studies by University of Chicago psychologist Susan Goldin-Meadow and a team of researchers found deaf people in Nicaragua, who had not learned formal sign language, do not have a complete understanding of numbers greater than three.

Researchers surmised the lack of large number comprehension was because the deaf Nicaraguans were not being taught numbers or number words.  Instead they learned to communicate using self-developed gestures called “homesigns,” a language developed in the absence of formal education and exposure to formal sign language.

“The research doesn’t determine which aspects of language are doing the work, but it does suggest that language is an important player in number acquisition,” said Betty Tuller, a program director in the National Science Foundation’s (NSF) Division of Behavioral and Cognitive Sciences, which funded the research.

“The finding may help narrow down the range of experiences that play a role in learning number concepts,” she said.

Research results are reported in the current issue of the Proceedings of the National Academy of Sciences (PNAS) in a paper titled, “Number Without a Language Model.”

While the homesigners do have gestures for number, those gestures are accurately used for only small numbers–numbers less than three–and not for large ones.

By contrast, deaf people who acquire conventional sign languages learn the values of large numbers because they learn a counting routine early in childhood, just as children who acquire spoken languages do.

“It’s not just the vocabulary words that matter, but understanding the relationships that underlie the words–the fact that “Ëœeight’ is one more than ‘seven’ and one less than ‘nine,'” said Goldin-Meadow. “Without having a set of number words to guide them, the deaf homesigners in the study failed to understand that numbers build on each other in value.”

“What’s most striking is that the homesigners can see that seven fingers are more than six fingers and less than eight fingers, but they are unable to order six, seven and eight fingers,” added Tuller. “In other words, they don’t seem to understand the successor function that underlies number.”

The complexity for homesigners learning seemingly simple concepts such as “seven” may help researchers learn more about the important role language plays in how all children learn early mathematical concepts, especially children who are having trouble learning number concepts in their preschool years.

Scholars previously found that in isolated cultures where the local language does not have large number words, people do not learn the value of large numbers. Two groups of people studied in the Amazon, for instance, do not have words for numbers greater than five. But their culture does not require the use of exact large numbers, which could explain the Amazonians’ difficulty with these numbers.

In Nicaraguan society, however, exact numbers are an important part of everyday life, as Nicaraguans use money for their transactions. Although the deaf homesigners in the University of Chicago study understand the relative value of their money, their understanding is incomplete because they have never been taught number words, said Elizabet Spaepen, the study’s lead author.

For the study, the scholars gave the homesigners a series of tasks to determine how well they could recognize money. They were shown a 10-unit bill and a 20-unit bill and asked which had more value. They were also asked if nine 10-unit coins had more or less value than a 100-unit bill. Each of the homesigners was able to determine the relative value of the money.

“The coins and bills used in Nicaraguan currency vary in size and color according to value, which give clues to their value even if the user has no knowledge of numbers,” Spaepen said. The deaf homesigners could be learning rote information about the currency based on the color and shape of the currency without fully understanding numerical value.

“The findings show that simply living in a numerate culture isn’t enough to develop an understanding of large number,” said Tuller. “This conclusion comes from the observation that the homesigners are surrounded by hearing individuals who deal with large numbers all of the time.

“The findings point toward language since that’s what the homesigners lack,” she said. “In all other respects they are fully functioning members of their community. But that doesn’t mean that there might not be other, nonlinguistic ways of teaching them, or others, the idea of an exact large number.”

The research team is currently working on developing a training procedure to do exactly that–train deaf homesigners the meaning of number using nonlinguistic means.

Other authors on the paper are Marie Coppola, Assistant Professor in Psychology at the University of Connecticut; Elizabeth Spelke, the Marshall L. Berkman Professor of Psychology at Harvard; and Susan Carey, Professor of Psychology at Harvard.

NSF supports all fields of fundamental science and engineering, except for medical sciences, by funding the research of scientists, engineers and educators directly through their own home institutions, typically universities and colleges.

Image Caption: Nicaraguan homesigners surrounded by hearing individuals who deal with large numbers all of the time do not have a complete understanding of numbers greater than three. Researchers conclude this is because they are not being taught numbers or number words. Here, American sign language for “three,” “seven” and “eight” are shown. Credit: © 2011 Jupiterimages Corporation

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Eggs Are Now Naturally Lower In Cholesterol

New study shows large eggs are 14 percent lower in cholesterol and 64 percent higher in vitamin D

According to new nutrition data from the United States Department of Agriculture’s Agricultural Research Service (USDA-ARS), eggs are lower in cholesterol than previously thought. The USDA-ARS recently reviewed the nutrient composition of standard large eggs, and results show the average amount of cholesterol in one large egg is 185 mg, 14 percent lower than previously recorded. The analysis also revealed that large eggs now contain 41 IU of vitamin D, an increase of 64 percent.

“We collected a random sample of regular large shell eggs from 12 locations across the country to analyze the nutrient content of eggs,” says Dr. Jacob Exler, Nutritionist with the Agricultural Research Service’s Nutrient Data Laboratory. “This testing procedure was last completed with eggs in 2002, and while most nutrients remained similar to those values, cholesterol decreased by 14 percent and vitamin D increased by 64 percent from 2002 values.”

The collected eggs were sent to a laboratory at Virginia Tech University to be prepared for nutrient analysis at certified nutrient analysis laboratories. The samples were randomly paired for the testing procedure, and the analysis laboratories tested samples to determine composition of a variety of nutrients including protein, fat, vitamins and minerals. Accuracy and precision were monitored using quality control samples.

According to Dr. Exler, this procedure is standard for the National Food and Nutrient Analysis Program (NFNAP), the program responsible for analyzing the nutrient composition of a wide variety of foods and making nutrition information publicly available. This information is available on the nutrient data lab website at www.ars.usda.gov/nutrientdata. The new nutrient information will also be updated on nutrition labels to reflect these changes wherever eggs are sold, from egg cartons in supermarkets to school and restaurant menus.

Cracking Egg Myths

Over the years, Americans have unnecessarily shied away from eggs ““ despite their taste, value, convenience and nutrition ““ for fear of dietary cholesterol. However, more than 40 years of research have demonstrated that healthy adults can enjoy eggs without significantly impacting their risk of heart disease.

“My research focuses on ways to optimize diet quality, and I have long suspected that eliminating eggs from the diet generally has the opposite effect. In our own studies of egg intake, we have seen no harmful effects, even in people with high blood cholesterol,” says Dr. David Katz, Director of the Yale University Prevention Research Center.

Enjoying an egg a day can fall within current cholesterol guidelines, particularly if individuals opt for low-cholesterol foods throughout the day. The 2010 Dietary Guidelines for Americans suggest that eating one whole egg per day does not result in increased blood cholesterol levels and recommend that individuals consume, on average, less than 300 mg of cholesterol per day. A single large egg contains 185 mg cholesterol.

Some researchers believe the natural decrease in the cholesterol level of eggs could be related to the improvements farmers have made to the hens’ feed. Hens are fed a high-quality, nutritionally balanced diet of feed made up mostly of corn, soybean meal, vitamins and minerals. Poultry nutrition specialists analyze the feed to ensure that the natural nutrients hens need to stay healthy are included in their diets. Nutrition researchers at Iowa State University are compiling a report to outline potential reasons for the natural decrease in cholesterol in eggs.

Nutrient-Rich Eggs

Eggs now contain 41 IU of vitamin D, which is an increase of 64 percent from 2002. Eggs are one of the few foods that are a naturally good source of vitamin D, meaning that one egg provides at least 10 percent of the Recommended Daily Allowance (RDA). Vitamin D plays an important role in calcium absorption, helping to form and maintain strong bones.

The amount of protein in one large egg ““ 6 grams of protein or 12 percent of the Recommended Daily Value ““ remains the same, and the protein in eggs is one of the highest quality proteins found in any food. Eggs are all-natural, and one egg has lots of vitamins and minerals all for 70 calories. The nutrients in eggs can play a role in weight management, muscle strength, healthy pregnancy, brain function, eye health and more. At less than 15 cents apiece, eggs are an affordable and delicious breakfast option.

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Bad Things Seem Even Worse If People Have To Live Through Them Again

Prospect of repeating an experience can change how one remembers it, research says

When people think unpleasant events are over, they remember them as being less painful or annoying than when they expect them to happen again, pointing to the power of expectation to help people brace for the worst, according to studies published by the American Psychological Association.

In a series of eight studies exposing people to annoying noise, subjecting them to tedious computer tasks, or asking them about menstrual pain, participants recalled such events as being significantly more negative if they expected them to happen again soon.

This reaction might be adaptive: People may keep their equilibrium by using memory to steel themselves against future harm, said co-authors Jeff Galak, PhD, of Carnegie Mellon University, and Tom Meyvis, PhD, of New York University. Their findings appear in the February issue of the Journal of Experimental Psychology: General.

The laboratory studies (of 30, 44, 112, 154, 174, 160 and 51 subjects) exposed people to five seconds of vacuum cleaner noise. People who were told they would have to listen to more vacuum cleaner noise said it was significantly more irritating than people who were told the noise was over.

Subsequent studies replicated this finding using larger samples and boring, repetitive tasks — such as dragging circles from the left to the right side of a computer screen 50 times. Again, people who were told they would have to do it again said the task was significantly more irritating, boring and annoying than people told when they were done.

Other studies varied the method to allow researchers to understand what subjects were experiencing emotionally. For example, the researchers found evidence that people used more intensely negative memories to steel themselves against the future. Also, not having time to reflect on the first experience, or having their resources drained by a demanding “filler” task, reduced the power of expectation.

Also, people recalled fun activities, such as playing video games, as equally enjoyable whether they thought they would play again or not. The authors concluded that emotions negatively shape memory’s judgment of unpleasant experiences, but positively shape the recollected quality of pleasant experiences.

In the culminating field study of 180 women (average age 29), those whose menstrual periods had ended fewer than three days earlier or who expected their periods within three days remembered their last period as significantly more painful than women in the middle of their cycle (none were currently menstruating).

“The prospect of repeating an experience can, in fact, change how people remember it,” the authors concluded. Bracing for the worst may actually help people to reduce their discomfort if a bad experience should happen, and allow them to be pleasantly surprised if it does not, they added.

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New Explanation For Chocolate’s Heart-healthy Benefits

In time for the chocolate-giving and chocolate-noshing fest on Valentine’s Day, scientists are reporting discovery of how this treat boosts the body’s production of high-density lipoprotein cholesterol (HDL) “” the “good” form of cholesterol that protects against heart disease. Just as those boxes of chocolates get hearts throbbing and mouths watering, polyphenols in chocolate rev up the activity of certain proteins, including proteins that attach to the genetic material DNA in ways that boost HDL levels. Their report appears in the Journal of Agricultural and Food Chemistry, one of 39 peer-reviewed scientific journals published by the American Chemical Society.

Midori Natsume, Ph.D., and colleagues note that studies have shown that cocoa, the main ingredient in chocolate, appears to reduce the risk of heart disease by boosting levels of HDL, or “good” cholesterol, and decreasing levels of low-density lipoprotein (LDL), or “bad” cholesterol. Credit for those heart-healthy effects goes to a cadre of antioxidant compounds in cocoa called polyphenols, which are particularly abundant in dark chocolate. Until now, however, nobody knew exactly how the polyphenols in cocoa orchestrated those beneficial effects.

The scientists analyzed the effects of cocoa polyphenols on cholesterol using cultures of human liver and intestinal cells. They focused on the production of apolipoprotein A1 (ApoA1), a protein that is the major component of “good” cholesterol, and apolipoprotein B (ApoB), the main component of “bad” cholesterol. It turns out that cocoa polyphenols increased ApoA1 levels and decreased ApoB levels in both the liver and intestine. Further, the scientists discovered that the polyphenols seem to work by enhancing the activity of so-called sterol regulatory element binding proteins (SREBPs). SREBPs attach to the genetic material DNA and activate genes that boost ApoA1 levels, increasing “good” cholesterol. The scientists also found that polyphenols appear to increase the activity of LDL receptors, proteins that help lower “bad” cholesterol levels.

The American Chemical Society is a non-profit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world’s largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

Reference: Journal of Agricultural and Food Chemistry. “Cacao Polyphenols Influence the Regulation of Apolipoprotein in HepG2 and Caco2 Cells”

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Smaller Brain, Better Intelligence?

Puzzled scientists are debating if the shrinking brains of humans is a sign we are growing dumber or that evolution is making the key motor leaner and more efficient.

The average size of modern human brains has decreased about 10 percent during the last 30,000 years — from 1,500 to 1,359 cubic centimeters, the size of a tennis ball, reports the AFP news agency.

The brains of females, which are on average smaller than those of men, have also experienced an equivalent drop in size. These measurements were taken using skulls found in Europe, the Middle East and Asia.

“I’d called that a major downsizing in an evolutionary eye blink,” John Hawks of the University of Michigan told Discover magazine. Other anthropologists however, note that brain shrinkage is not surprising as the stronger and larger we are the more gray matter we need to control this larger mass.

The Neanderthal, a cousin of the modern human who disappeared about 30 millennia ago was far more massive and had a larger brain. The Cro-Magnons were the Homo sapiens with the biggest brain. They were also stronger than their modern descendants.

David Geary, a psychology professor at the University of Missouri reports these traits were necessary to survive in the hostile environment of the distant past. He has studied the evolution of skull sizes 1.9 million to 10,000 years old as our ancestors and cousins lived in an increasingly complex social environment.

Using population density as a measure of social complexity, Geary and his colleagues hypothesize that the more humans are living closer together, the greater the exchanges between groups, the division of labor and the rich and varied interactions between people.

Finding that brain size decreased as population density increased, Geary tells AFP, “As complex societies emerged, the brain became smaller because people did not have to be as smart to stay alive.”

Downsizing however does not mean modern humans are dumber than their ancestors — instead, they developed more sophisticated forms of intelligence, said Brian Hare, an assistant professor of anthropology at Duke University. He noted that the same phenomenon can be observed in domestic animals compared to their wild counterparts.

Huskies may have smaller brains than wolves, but they are smarter and more sophisticated. Huskies can understand human communicative gestures, behaving similarly to human children.

“Even though the chimps have a larger brain (than the bonobo, the closest extant relative to humans), and even though a wolf has a much larger brain than dogs, dogs are far more sophisticated, intelligent and flexible, so intelligence is not very well linked to brain size,” Hare explained to AFP.

Humans have characteristics from both the bonobo and chimpanzee, which is more aggressive and domineering. “The chimpanzees are violent because they want power, they try to have control and power over others while bonobos are using violence to prevent one for dominating them,” Hare continued.

“Humans are both chimps and bonobos in their nature and the question is how can we release more bonobo and less chimp.”

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Americans Using Antidepressants Without Proper Diagnosis

Nearly 25 percent of all Americans taking antidepressants have never received any diagnosis from a specialist for any conditions the drugs are used to treat, according to new research from the University of Manitoba.

Researchers say that millions of people could be taking medicines that have no proven health benefits and are exposed to side effects they do not need.

“We cannot be sure that the risks and side effects of antidepressants are worth the benefit of taking them for people who do not meet criteria for major depression,” said Jina Pagura, a medical student and psychologist at the University of Manitoba in Canada, who worked on the research.

“These individuals are likely approaching their physicians with concerns that may be related to depression, and could include symptoms like trouble sleeping, poor mood, difficulties in relationships, etc,” she told Reuters Health by email. “Although an antidepressant might help with these issues, the problems may also go away on their own with time, or might be more amenable to counseling or psychotherapy.”

Pagura and colleagues used data from the Collaborative Psychiatric Epidemiologic Surveys, which includes a perspective sample of more than 20,000 US adults interviewed between 2001 and 2003.

About 10 percent of the sample told interviewers they had been taking antidepressants during the past year. Yet nearly a quarter of those people had never been diagnosed with any conditions usually treated with that type of medication, such as depression and anxiety.

Nearly 15 million American adults suffer from major depression, and another 40 million have some type of anxiety disorder, according to the National Institute of Mental Health.

Although all forms of mental illness were not included in the survey, mental health experts said the new findings are not exaggerated.

“Reviews of claims records, which are diagnoses actually given by health care professionals, suggest that only about 50% of patients who are prescribed antidepressants receive a psychiatric diagnosis,” Dr Mark Olfson, a psychiatrist at Columbia University in New York, told Reuters Health in an email.

“These findings raise questions about the clinical appropriateness of antidepressant treatment selection for many primary care patients,” he added.

The sale and use of antidepressants in the United States currently ranks fourth among all prescription drugs, according to IMS Health, who said sales in 2009 reached nearly $10 billion, up three percent from the previous year.

While studies show that antidepressants may help some people with depression, they come with a cost. Beside the $100+ monthly price tag on many antidepressants, some users may experience sexual problems or gain weight when using them.

“Nearly all medication has side effects, so there are undoubtedly a large number of Americans who are taking antidepressants that may not be effective at treating their conditions, yet they suffer from the side effects,” said Jeffrey S. Harman, a health services expert at the University of Florida in Gainesville, who was not involved in the research.

“Not to mention inappropriate use of our health care dollars that comes along with inappropriate prescribing,” he added.

The findings do not necessarily mean doctors are prescribing more antidepressants than they should, however, said Harman. “As far as over-prescribing, I don’t think you can say that it is occurring as a blanket statement “¦ there are undoubtedly many people being prescribed antidepressants that may not be effective for them, but there are also millions of Americans suffering from depression who are not being prescribed antidepressants or are being prescribed them at a suboptimal dose,” he explained.

Although not commenting directly on the new research findings, Pfizer told Reuters Health that it was dedicated to ensuring “that patients and their doctors have the most up to date medical information on which to base their treatment decisions.”

The new research was published in the Journal of Clinical Psychiatry.

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Newborn Size Affected By Mother’s Age

New study by Dutch researchers suggests that bigger babies are born to older women, while younger women have smaller babies.

Previous studies hinted at the link between a mom’s age and her baby’s birth weight, as well as possible health consequences that may arise when babies are too small or too big. Babies who grow smaller than normal in the womb are at risk for increased birth complications, and are more likely to have diabetes and heart disease in adulthood. Babies who grow larger in the womb are more likely to become obese later in life.

The new study says past findings could be particularly relevant as the age at which women are giving birth is still growing in the Western world.

According to a 2010 study by the Pew Research Center, the percentage of US babies born to women older than 35 grew from 9 percent in 1990 to 14 percent in 2008.

Rachel Bakker of the Erasmus Medical Center in Rotterdam, the Netherlands and her colleagues studies more than 8,500 Dutch women who gave birth between 2002 and 2006.

In the study, the average newborn weighed 7.7 pounds. Researchers defined “small” as a baby weighing 5.5 pounds or less and a “large” baby as weighing 10 pounds or more.

Based on the childbirths in the study, about one in 20 newborns are born small, and an additional one in 20 are born large.

Compared to women between the ages of 30 and 35, those under 25 tended to be more likely to have small babies. About 4 percent of 30-to-35-year-olds had small newborns, while 7 percent of mothers under 20 had smaller babies.

The study found that older mothers were more likely to have large babies. The risk of having a large baby went from 3 percent in very young women, to almost 6 percent in those between 30 and 35, to roughly 10 percent in mothers over 40 years old.

In the young mothers, the link between age and risk of delivering small babies was mostly due to social factors (including ethnicity, education level, and how many times a woman had given birth before) and lifestyle factors (like diet, smoking and alcohol use).

In other age groups, social factors could also explain why younger women tended to have smaller babies. But none of the factors could explain why the risk of having a large baby went up in older women.

The findings could also suggest that other factors in women’s bodies might be playing a role, but the team said it is unclear right now what those factors may be.

Bakker said more research is needed to clarify what factors are associated with mother age and birth weight, and to find the range of potential health effects.

The findings do not mean a mother’s age alone causes her baby to be born large or small, according to the team of researchers. Other factors could also affect the newborn’s size, including mother’s weight, tobacco and alcohol use, and how many other childbirths the mother went through.

In the meantime, there isn’t enough information available “to advise women about the most optimal age to have children,” Bakker to Reuters Health in an email.

The study was published in January in the British Journal of Obstetrics and Gynecology.

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Dating Sites Caught Using Facebook Photos

A brand new dating website launched Friday makes its mark by allowing visitors to seek potential mates by searching through profile pictures the site owners jacked from Facebook.

The site, Lovely-faces.com, took an estimated 250,000 pictures from Facebook which can be searched in a number of different categories, including gender, race, funny and smug.

The creators of the “dating agency” were identified as Paolo Cirio and Alessandro Ludovic. In an online statement datelined in Berlin, the authors said: “Our mission was to give all these virtual identities a new shared place to expose themselves freely, breaking Facebook’s constraints and boring social rules.”

The two men explained that nearly a million “stolen” profile pictures were analyzed using facial recognition software that filtered the images by their expressions. “Immersing ourselves in the resulting database was a hallucinatory experience as we dove into hundreds of thousands of profile pictures and found ourselves intoxicated by the endless smiles, gazes and often leering expressions,” the duo said.

“We established a new website (lovely-faces.com) giving them justice and granting them the possibility of soon being face to face with anybody who is attracted by their facial expression and related data,” they added.

Facebook grimaced over the dating website, saying that mining information violates the terms of service at the top online social network. Facebook was probing into the matter and promised it would take “appropriate” action.

Ironically, Facebook cofounder Mark Zuckerberg was once in trouble for hacking Harvard University computers while a student there to get pictures of coeds for comparison with each other at a website he created called “Face Mash.”

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Researchers Grow Their Own Blood Vessels

Scientists reported on Wednesday that they have successfully grown bio-engineered blood vessels that surgeons could someday take off the shelf and implant into patients, something that could ultimately help people lacking healthy veins for coronary bypass surgery or dialysis.

The researchers employed a novel way of using human cells to generate the blood vessels that could allow them to function without triggering a patient’s immune response. Furthermore, unlike other engineered vessels, these can be stored for up to one year, allowing hospitals to keep them on hand for immediate use.

“This new type of bioengineered vein allows them to be easily stored in hospitals so they are readily available to surgeons at the time of need,” said Dr. Alan Kypson, Associate Professor of Cardiothoracic Surgery at East Carolina University, who authored a report about the findings.

“Currently, grafting using the patient’s own veins remains the gold standard. But, harvesting a vein from the patient’s leg can lead to complications, and for patients who don’t have suitable veins, the bioengineered veins could serve as an important new way to provide a coronary bypass,” Dr. Kypson said.

The bio-engineered vessels also have “decreased potential for infection, obstruction or clotting,” wrote the researchers from Duke, Yale and East Carolina University.

The team created the bio-engineered blood vessels by taking smooth muscle cells from a human cadaver and grafting them onto tubes made of polyglycolic acid — the material used in making dissolvable stitches.

Within eight to 10 weeks, the tubes degrade, leaving behind a “fully formed vascular graft”.

The veins have been tested in dogs and baboons, and were not rejected by their bodies and functioned well for six months.

The vessels can be stored in saline solution for up to 12 months, which would allow surgeons to select an “off the shelf” vessel for use in a sick patient, the researchers said.

“These can be made ahead of time and then are ready to go whenever they are needed,” the researchers said.

According to the National Kidney Foundation, 320,000 patients require dialysis, more than half of which lack the healthy veins necessary for the procedure and must therefore undergo arteriovenous graft (AV graft) placement.

“Most AV grafts that are placed for hemodialysis access are comprised of a synthetic material, which suffers from significant drawbacks including a high rate of infection, or a propensity for occlusion due to thrombosis and intimal hyperplasia,” said Dr. Jeffrey Lawson, Associate Professor of Surgery at Duke University School of Medicine and an author of the research.

“Due to high complication rates, each AV dialysis graft requires an average of 2.8 interventions over its lifetime just to keep it functioning. Hence, there is a huge clinical need for a functionally superior, off-the-shelf, AV graft that suffers from fewer complications than current materials.”

Humacyte, a North Carolina-based regenerative medicine firm that funded and contributed to the research, said clinical trials in humans would begin soon.

Shannon Dahl, Humacyte’s co-founder and senior director of scientific operations, said veins can be constructed in different sizes according to the type of operation required.

“We can make the bio-engineered veins in large and small diameter, which means they can be used for procedures ranging from hemodialysis for patients with kidney failure and for coronary by-pass.”

Around 400,000 coronary bypass procedures are performed each year in the U.S., according to the American Heart Association.

“Not only are bioengineered veins available at the time of patient need, but the ability to generate a significant number of grafts from a cell bank will allow for a reduction in the final production costs, as compared to other regenerative medicine strategies,” Dahl said.

“While there is still considerable research to be done before a product is available for widespread use, we are highly encouraged by the results outlined in this paper and eager to move forward with additional study.”

The study was published February 2 in the journal Science Translational Medicine.

Image 2: This is a 6 mm-diameter decellularized human bioengineered vein before implant. Credit: Science/AAAS

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Power And Potential Of X-ray Laser Power

Two studies published in the February 3 issue of Nature demonstrate how the unique capabilities of the world’s first hard X-ray free-electron laser””the Linac Coherent Light Source, located at the Department of Energy’s SLAC National Accelerator Laboratory””could revolutionize the study of life.

In one study, an international research team used the LCLS to demonstrate a shortcut for determining the 3-D structures of proteins. The laser’s brilliant pulses of X-ray light pulled structural data from tiny protein nanocrystals, avoiding the need to use large protein crystals that can be difficult or impossible to prepare. This could lop years off the structural analysis of some proteins and allow scientists to decipher tens of thousands of others that are out of reach today, including many involved in infectious disease.

In a separate paper, the same team reported making the first single-shot images of intact viruses, paving the way for snapshots and movies of molecules, viruses and live microbes in action.

Led by Henry Chapman of the Center for Free-Electron Laser Science at the German national laboratory DESY and Janos Hajdu of Sweden’s Uppsala University, the team of more than 80 researchers from 21 institutions performed these experiments in December 2009, just two months after the LCLS opened for research. Their studies are the first to demonstrate the power and potential of the LCLS for biology.

“The LCLS beam is a billion times brighter than previous X-ray sources, and so intense it can cut through steel,” Chapman said. “Yet these incredible X-ray bursts are used with surgical, microscopic precision and exquisite control, and this is opening whole new realms of scientific possibilities,” including the ability to observe atoms moving and chemical bonds forming and breaking in real time.

Outrunning a laser blast

In the experiments, scientists sprayed viruses or nanocrystals into the path of the X-ray beam and zapped them with bursts of laser light. Each strobe-like laser pulse is so brief “”a few millionths of a billionth of a second long””that it gathers all the information needed to make an image before the sample explodes.

Hajdu had proposed this method nearly a decade earlier. Researchers at Arizona State University, Lawrence Livermore National Laboratory, SLAC and Uppsala spent years developing specialized equipment for injecting samples into the beam, and Germany’s Max Planck Advanced Study Group brought in a 10-ton, $7 million instrument called CAMP to record every single photon of data with a fast, ultra-sensitive X-ray camera for later analysis.

Tests at DESY and Lawrence Berkeley National Laboratory showed that the concept worked at lower X-ray energies. “But as you go to higher energies, can you still outrun the damage?” said team member Michael Bogan, a SLAC staff scientist and principal investigator at the PULSE Institute for Ultrafast Energy Science, jointly located at SLAC and Stanford University. The answer, he said, was yes: “The physics still holds.”

A big payoff from tiny crystals

The protein structure experiments were led by Chapman and Arizona State’s John Spence and Petra Fromme. They chose as their target Photosystem I, a biological factory in plant cells that converts sunlight to energy during photosynthesis. It’s one of an important class of proteins known as membrane proteins that biologists and drug developers are eager to understand better.

Embedded in cell membranes, these proteins control traffic in and out of the cell and serve as docking points for infectious agents and disease-fighting drugs; in fact, they are the targets of more than 60 percent of the drugs on the market. Yet scientists know the structures of only six of the estimated 30,000 membrane proteins in the human body, given the difficulty of turning them into big crystals for conventional X-ray analysis.

To get around this bottleneck, the researchers squirted millions of nanocrystals containing copies of Photosystem I across the X-ray beam. Laser pulses hit the crystals at various angles and scattered into the detector, forming the patterns needed to reconstitute images. Each crystal immediately vaporized, but by the time the next pulse arrived another crystal had moved into the bull’s eye.

The team combined 10,000 of the three million snapshots they took to come up with a good match for the known molecular structure of Photosystem I.

“I attended several meetings this summer where this work was presented and I was extraordinarily excited by it,” Michael Wiener of the University of Virginia, who was not involved in the research, said of the results. He leads one of nine institutes set up by the National Institutes of Health to decipher the structures of membrane proteins. “Preparation of these nanocrystals is likely to be very, very much easier than the larger crystals used to date,” Wiener said, leaving scientists more time and money to find out how these important biomolecules work.

The team is scheduled to return to the LCLS this month to repeat the experiments with X-ray laser pulses that are much faster and deliver four times as much energy as they did in the initial round. If the physics still hold, future images should capture the extraordinarily complex structure of Photosystem I in atom-by-atom detail.

Portraits of a virus

For the second experiment, the team went a step beyond nanocrystals to no crystals at all. Led by Hajdu, they made single-shot portraits of individual virus particles. These snapshots are a step toward eventually producing stop-action movies of chemical changes taking place in molecules and within living cells.

Biologists have long dreamed of making images of viruses, whole microbes and living cells without freezing, slicing or otherwise disturbing them. This is one of the goals of the LCLS, and the researchers tested its capabilities on Mimivirus, the world’s largest known virus, which infects amoebas.

Of the hundreds of Mimiviruses hit by the LCLS beam, two produced enough data to allow scientists to reconstitute their images. The images show the 20-sided structure of the Mimi’s outer coat and an area of denser material inside, which may represent its genetic material. Shorter, brighter pulses focused to a smaller area should greatly improve the resolution of these images to reveal details as small as one nanometer, the team wrote in their Feb. 3 Nature report.

Getting a detailed picture of the internal structure of an individual virus “would be a great achievement,” said team member Jean-Michel Claverie, director of the Structural & Genomic Information Lab in Marseille and one of the scientists who discovered Mimi’s viral nature.

“This is a brand-new way to look at a biological object,” he said. “This will allow us to address not only the questions related to the internal structure of the virus, but its intrinsic variability from one individual virus particle to the next””a microscopic variability that might play a fundamental role in evolution.”

The team returned to the LCLS in January to look at the Mimivirus at X-ray wavelengths that should maximize the amount of contrast and detail in the images. They will be analyzing the results in the months to come.

SLAC Director Persis Drell, who sat in a control room packed with scientists as raw data from the two experiments came in, said the experience was thrilling””and so is the potential for biology and medicine.

“This first data and these first papers are really just the first view of a new research frontier,” she said. “They represent a turning point for the LCLS, demonstrating new technologies that will be great steps forward.”

Image 1 Caption: A three-dimensional rendering of X-ray data obtained from over 15,000 single nanocrystal diffraction snapshots recorded at the Linac Coherent Light Source, the world’s first hard X-ray free-electron laser, located at SLAC National Accelerator Laboratory. The 3-D structure of proteins — in this case Photosystem I, the biological factory in plant cells that converts sunlight to energy during photosynthesis — can be determined from these diffraction patterns. Each nanocrystal was destroyed by the intense X-ray pulse, but not before information about its structure was revealed. (Credit: Thomas White, DESY)

Image 2 Caption: The experimentally measured X-ray diffraction pattern of a single Mimivirus particle, imaged at the Linac Coherent Light Source, the world’s first hard X-ray free-electron laser, located at SLAC National Accelerator Laboratory. Very short and extremely bright X-ray pulses can be used to obtain a single diffraction pattern from a large macromolecule, a virus or a cell before the sample explodes and turns into plasma. The structure of the virus can be determined from such patterns. In this study, the X-ray pulse lasted a millionth of a billionth of a second and heated the virus to 100,000 degrees Celsius, but not before this image was obtained. (Credit: Janos Hajdu, Uppsala University)

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Synthetic Materials That Behave Like Mollusk Shells

Nacre, commonly known as mother-of-pearl, is the iridescent material lining many mollusk shells. It is part of a two-layer armor system that protects the animal from predators. The brittle outer layer of the shell absorbs the initial impact, but is prone to cracking. To prevent these cracks from catastrophically propagating through the shell to the animal itself, the nacreous layer is surprisingly strong and tough, with outstanding crack arresting properties. Thus it acts as a lining to maintain the integrity of the shell in the event of cracking of the outer layer.

“What makes this natural material unique is that it is composed of relatively weak constituents,” said Owen Loh, a graduate student at Northwestern University. At the microscale, brittle calcite tablets are stacked in a brick-and-mortar-like structure with thin layers of biopolymer lining the interfaces between tablets. This results in a material that well outperforms its individual constituents. For example, the toughness of nacre is orders of magnitude greater than that of the tablet material itself. In addition, nacre is at once strong and tough, a combination that is generally mutually exclusive in engineering materials.

As a result, nacre has been the object of significant interest within the materials community and serves as a model after which numerous man-made composite materials are designed. This includes composites for light-weight armor systems and structural elements in transportation and aerospace applications.

Nacre’s outstanding performance has long been attributed to its brick-and-mortar microstructure. However, the specific attributes of this hierarchical structure, which contribute to the toughness of nacre, have been the subject of debate. As a result, efforts to translate deformation mechanisms observed in nacre into man-made composite materials have been widespread but mostly unsuccessful.

In a paper published online in the journal Nature Communications, Horacio Espinosa, the James N. and Nancy J. Farley Professor in Manufacturing and Entrepreneurship at the McCormick School of Engineering and Applied Science at Northwestern, Loh and colleagues report the identification of specific characteristics of the material microstructure that enable its outstanding performance. By performing detailed fracture experiments within an atomic force microscope, the group was able to directly visualize and quantify the way the tablets slid relative to each other as the material is deformed.

The group previously found that the tablets are not perfectly flat but instead have an inherent waviness in their surfaces. As a result, they tend to interlock as they slide relative to each other, spreading damage and dissipating energy over large areas. “We published these results before but it took atomic scales experiments to confirm our hypothesis on the origin of toughness in these biomaterials,” Espinosa said.

The group then applied the findings to the design of artificial composites. “We took what we learned from natural nacre and designed a scaled-up artificial composite material with an interlocking tablet structure,” said Pablo Zavattieri, a co-author of the paper and assistant professor of civil engineering at Purdue University. “By applying nacre’s highly effective toughening mechanism to this material, we were able to achieve a remarkable improvement in energy dissipation.”

The findings have important implications for future design of high-performance composite materials. “We believe these findings may hold a key to realizing the outstanding potential of nanocomposites,” Espinosa said. “While carbon nanotubes and other nanoscale reinforcements utilized in these materials have unprecedented properties, their performance has yet to be translated to bulk composites. By implementing toughening mechanisms such as those we found in natural nacre, we may be able to achieve this.”

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Scripps Research Scientist Discovers Natural Molecule Indirectly Prevents Stable Clot Formation

The findings suggest a possible novel target for the treatment of hemophilia A

A scientist from The Scripps Research Institute has identified a new role for a natural signaling molecule in preventing blood clot formation. The molecule could become a target for the development of novel and cost-effective treatments for blood clotting diseases such as Hemophilia A.

The findings, from a study by Scripps Research Assistant Professor Laurent O. Mosnier, were published in a recent edition of Journal of Biological Chemistry.

The study focused on Platelet Factor 4 ““ a small cytokine (intracellular signaling molecule) released during platelet aggregation.

Based on Platelet Factor 4 effects on another coagulation protein, it was thought that Platelet Factor 4 could potentially stimulate activation of thrombin-activatable fibrinolysis inhibitor (TAFI) ““ an enzyme (soluble protein) that protects clot longevity, making clots last longer and preventing excess bleeding; TAFI is like a hardener that is added to the mortar used between the bricks in a brick wall, without which the mortar would never completely solidify, and the wall would never be solid.

The new study, however, found exactly the opposite role for Platelet Factor 4″”inhibition of TAFI activation.

For Mosnier, this finding led to a radical idea””sequestering Platelet Factor 4 using such molecules as heparin derivatives could improve clot stability. Heparin – a highly sulfated or negatively charged glucoseaminoglycan (polysaccharide or sugar derivative) ““ is a commonly used anticoagulant. Mosnier, however, was able to modify the compound to have the reverse effect and aid in blood clotting in laboratory tests.

“The idea of using heparin to prevent bleeding in kids [who have bleeding tendencies] would be outrageous because that would just greatly accelerate bleeding,” said Mosnier, “Our trick, however, was to modulate heparin’s anticoagulant properties. This opens up new possibilities.”

Converting Heparin from an Anticoagulant into a Non-Anticoagulant

Heparin’s anticoagulant activity is derived from a specific pattern of nitrogen- and oxygen-linked sulfation (or simply negative charges) that is recognized by anti-thrombin ““ the inactivator of coagulation. However, in addition to binding to anti-thrombin heparin also binds to Platelet Factor 4, which is glittered with positive charge, and they attract one another like magnets.

Mosnier found heparin’s anticoagulant activity could be prevented, and its Platelet Factor 4 binding selected for, by selectively removing the N-linked sulfations (and further acetylation). This effectively prevented heparin from being recognized by anti-thrombin and allowed it to instead take the Platelet Factor 4 out of the equation. This resulted in prevention of clot breakdown (fibrinolysis), by allowing TAFI to do its job.

To test the effectiveness of the modified heparin derivatives in enhancing clot stability, Mosnier employed a functional assay called a “clot lysis assay.” Using a light scattering technique, plasma was used to generate a clot, which was degraded. Further modulation of the conditions allowed measurement of clot stability via TAFI activation. Mosnier found that, indeed, the modified-version heparin promoted clot stability.

Toward a Cheaper, Cost-Effective Treatment for Hemophilia A

An optimistic Mosnier admits his new discovery is in its infancy, but hopes it may one day provide an alternative treatment for bleeding conditions such as Hemophilia A.

Hemophilia A, which affects 1 in 5,000 males, is an X-linked genetic bleeding disorder whereby there is a reduced amount or activity of factor VIII. This results in the unstable clots, lacking fibrin ““ a fibrous clot-forming protein. Currently, the treatment for Hemophilia A is prophylactically taking factor VIII as a medicine to improve clotting. Unfortunately, immunity against factor VIII is a significant side effect.

Mosnier hopes that modification of heparin ““ which is cheaper than factor VIII and already used clinically ““ could one day stabilize clots in these patients.

“The next step is to see if the modified compound will improve bleeding complications in the Hemophilia mouse,” said Mosnier. “We are still a long way from claiming anything clinically.”

His optimism is contagious, however, and it is an exciting time for science in the Mosnier lab.

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Super Bowl Loss: A Health Risk for Fans?

(Ivanhoe Newswire) — Attention sports fans: If your team loses, your heart may be at risk.

Researchers assessed how often emotional stress translates to cardiac death in men, women and older people when their team lost a big game. They ran regression models for mortality rates for cardiac causes for the 1980 Los Angeles Super Bowl loss and the 1984 Los Angeles Super Bowl win.

Results showed the loss of 1980 increased total and cardiac deaths in both men and women and triggered more deaths in older patients. In contrast, a Super Bowl win reduced deaths in older people and women.

Specifically, in men, there was a 15-percent increase in all circulatory deaths associated with the Super Bowl loss. In women, there was a 27-percent increase in all circulatory deaths associated with the loss. In older patients, there was a 22-percent increase in circulatory deaths associated with the loss.

“Physicians and patients should be aware that stressful games might elicit an emotional response that could trigger a cardiac event,” Robert A. Kloner, M.D., Ph.D., of the Heart Institute, Good Samaritan Hospital and Keck School of Medicine at USC, was quoted as saying. “Stress reduction programs or certain medications might be appropriate for individual cases.”

SOURCE: Clinical Cardiology, Jan. 31, 2011

Researchers Crack Argentine Ant Genome

Researchers from a pair of California universities have successfully sequenced the genome of the Argentine ant, shedding light on exactly why the species has thrived and leading to hopes that the knowledge might lead to the development of more effective pest control solutions.

The draft genome of this specific creature, known scientifically as Linepithema humile, is one of three published by experts at University of California, Berkeley (UC Berkeley) and San Francisco State University in the journal Proceedings of the National Academy of Sciences (PNAS) Monday.

Joining it are the red harvester ant (Pogonomyrmex barbatus) and the red imported fire ant (Solenopsis invicta), while a fourth–the leaf-cutter ant (Atta cephalotes)–is scheduled for publication in the February 10 issue of the journal PLoS Genetics.

“The Argentine ant is a species of special concern because of its enormous ecological impact,” corresponding author Neil D. Tsutsui, an associate professor at UC Berkeley’s Department of Environmental Science, Policy & Management, said in a statement Monday.

“When the Argentine ants invade, they devastate the native insect communities while promoting the population growth of agricultural pests,” he added. “This genome map will provide a huge resource for people interested in finding effective, targeted ways of controlling the Argentine ant.”

Tsutsui, lead author Christopher D. Smith, an assistant professor of biology at San Francisco State University, and 48 other researchers joined forces on the project.

According to a January 31 press release from the San Francisco university, mapping the ant’s genome could led to “a better understanding of how larvae develop into queens or workers could support the development of new control methods that use more benign chemicals to limit the number of queens born in a colony, effectively sterilizing the population.”

“Our analysis suggests that ants may utilize the same genetic system as honeybees to create their social structures, although we have yet to understand whether the process works in exactly the same way across species,” Smith said.

Furthermore, according to AFP reports, the research team discovered that the Argentine ant has a total of 367 sensory receptors for odor (twice as many as honeybees) and 116 for taste (40 more than the mosquito), as well as a “genetic shield” that protects them “against harmful substances.”

Image Caption: This is an Argentine ant (Linepithema humile). Scientists have deciphered the genome of this household pest and invasive species. The sequenced genome, published in the Jan. 31 online early edition of the Proceedings of the National Academy of Sciences, could provide new insights on how embryos with the same genetic code develop into either queens or workers ants and may advance our understanding of invasion biology and pest control. Credit: Photo: www.alexanderwild.com

Image 2: The genome of the red harvester ant, a social insect, was recently sequenced in an effort to understand the evolution of complex societies. Credit: Joseph Berger, Bugwood.org; licensed under a Creative Commons Attribution-Noncommercial 3.0 United States License

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Gestational Diabetes Can Affect Mothers Later In Life

Gestational diabetes, a form of diabetes that may strike during pregnancy, may disappear after birth, but it remains a potential problem for the future of the mother’s health — a warning that many seem to be missing.

Nearly half of women who have had that form of diabetes — considered the pregnancy kind — go on to develop Type 2 diabetes in months to years after giving childbirth.

Yet new research into the issue, conducted by Quest Diagnostics, shows that fewer than 20 percent of those women return for a crucial test within six months of delivery. That is the first of the checkups that mothers are supposed to have every few years to protect against the return of diabetes, but nobody knows how many do.

It is a serious issue because if they only knew, many of these new moms could take steps to reduce the chance of developing Type 2 diabetes later in life.

“It’s almost as if you got a preview … a window to the future,” Dr. Ann Albright, a diabetes specialist with the Centers for Disease Control and Prevention (CDC), told The Associated Press. “This is a population that really should be targeted for intervention.”

The American Diabetes Association (ADA) has recommended a change in how pregnant women are tested that will identify more mild cases than today, based on recent studies that found treating mothers leads to easier deliveries. If obstetricians join the cause, it could have the potential to double diagnoses — although most mild cases would only require better nutrition and exercise regimes, and not medications, the ADA cautions.

The CDC recently estimated that nearly 26 million Americans have some form of diabetes, most of them being Type 2 diabetics linked to obesity. Tens of millions more have high enough blood sugar to be classified as pre-diabetic.

At the time of their pregnancy, women can have either Type 2 diabetes or the insulin-dependent Type 1. Women with Type 1 are urged to have their diabetes strictly controlled to avoid risks to both the baby and the mother.

But the CDC says somewhere between 2 and 10 percent of pregnant women develop gestational diabetes for the first time during pregnancy. If untreated, the mother’s high blood sugar can make the fetus grow too large, leading to C-sections and early deliveries. It can also trigger the life-threatening condition preeclampsia, and may also increase the baby’s risk of becoming obese in childhood.

Medical groups urge screening for most pregnant women. But nearly a third of them aren’t receiving the test, according to the research by Quest.

The Quest study examined the testing records of more than 900,000 pregnant women. In some of the records, doctors may have foregone with testing because they believed the mother was at low risk. Other records suggest that mothers may not have followed their doctor’s advice to get the test.

Although most mother’s blood sugar levels return to normal within a few weeks after childbirth, most doctors make it clear that patients need to be checked within six to 12 weeks to be sure. Quest tracked the records for a full six months, and found 19 percent had gotten that first checkup.

“The reality is that women get busy” with their new family, said Dr. Ellen Landsberger, obstetric diabetes director at New York’s Montefiore Medical Center, whose clinic takes measures to track the patients down. “Women take care of their children more than themselves,” she told The Associated Press.

The CDC says that women whose gestational diabetes goes away still need their blood sugar monitored every one to three years, because they are at a higher risk of developing Type 2 diabetes within the next 10 to 20 years.

This is because the body’s underlying ability to process blood sugar is forever altered, said Dr. Carol Wysham of the ADA, who heads the Rockwood Clinic Diabetes Center in Spokane, Washington.

For those women who can lose a modest amount of weight — 5 to 7 percent of starting pounds — and doing 150 minutes of physical activity per week are proven to prevent or at least delay Type 2 diabetes. Women who had gestational diabetes are no exception, making it even more important to lose that postpartum weight.

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Florida Judge Calls Healthcare Law Unconstitutional

President Barack Obama’s ground-breaking healthcare reform has met an obstacle after a federal judge from Florida called the overhaul unconstitutional on Monday.

US District Judge Roger Vinson ruled that the reform law’s so-called individual mandate went too far in requiring Americans to begin buying health insurance by 2014 or risk being penalized.

“Because the individual mandate is unconstitutional and not severable, the entire act must be declared void. This has been a difficult decision to reach, and I am aware that it will have indeterminable implications,” Vinson wrote.

Referring to a key provision in the Patient Protection and Affordable Care Act, Vinson sided with governors and attorneys general from 26 states, nearly all of whom are Republicans.

“Regardless of how laudable its attempts may have been to accomplish these goals in passing the Act, Congress must operate within the bounds established by the Constitution,” ruled Vinson.

The administration may now ask the appeals court to hold off on any law changes pending an appeal of Judge Vinson’s decision. The issue will likely end up at the Supreme Court for final determination.

Healthcare reform aims to expand health insurance to cover millions of uninsured Americans while curbing healthcare costs. Administration officials insist it is constitutional and needed to curb likely increases in healthcare costs.

Ron Pollack, executive director of Families USA, an influential national advocacy group that pushed for the healthcare overhaul, was disgusted with Vinson’s decision, calling it an example of “radical judicial activism run amok” and predicted it would be reversed on appeal.

“The decision flies in the face of three other decisions, contradicts decades of legal precedent, and could jeopardize families’ health care security,” Pollack told Reuters in a statement.

Vinson struggled with his decision, acknowledging that it was “hard to invalidate” the statute.

The individual mandate is key to the law’s mission of covering more than 30 million uninsured. Officials argue that the mandate is only requiring healthy people to purchase policies that they can help pay for reforms, including a mandate that individuals with pre-existing medical issues cannot be refused coverage.

The ruling follows the US House of Representatives vote earlier this month to repeal the healthcare overhaul law.

The repeal measure is unlikely to go any further as the Democratic-controlled Senate is expected to drop it. Legal experts agree the real battle over reform is destined for the Supreme Court.

States involved in the lawsuit are Alabama, Alaska, Arizona, Colorado, Florida, Georgia, Idaho, Indiana, Louisiana, Michigan, Mississippi, Nebraska, Nevada, Pennsylvania, South Carolina, North Dakota, South Dakota, Texas, Utah, Washington, Iowa, Ohio, Kansas, Maine, Wisconsin and Wyoming.

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Recommendations Changed For Vision Screening Of Children

On Monday, a federal expert panel backtracked on its 2004 recommendation to screen all kids younger than five years for poor vision, lazy eye and other eye conditions.

According to the U.S. Preventive Services Task Force (USPSTF), healthy children between three and five years should still be tested at least once, but there is not enough evidence to recommend screening of all young toddlers.

“There are harms associated with all screening tests,” said Dr. Ned Calonge, chair of the USPSTF and past president of the Colorado Board of Medical Examiners. “We don’t have good evidence of the harms, but we do know that at least some of these tests can generate a lot of false positives.”

A misdiagnosed child could end up with a bothersome eye patch or corrective lenses for no good reason.

Lazy eye affects between 2 and 4 percent of preschoolers.  It is the leading cause of poor vision in children and can lead to permanent vision loss on one eye if left untreated.

However, according to the USPSTF, screening young toddlers is hard because they tend to not cooperate well with the eye professionals.  Also, waiting for a few years before screening seems to be just as effective.

The new recommendations only cover those children without signs of vision problems.  They do not mean that parents with kids younger than three years should avoid making an appointment with the eye doctor if they are concerned.

“You may want to discuss screening with your healthcare provider, understanding that the evidence is insufficient at this point,” said Calonge, adding that some of the newer screening devices are expensive.

According to a new review of the medical literature published in the journal Pediatrics, there is only limited direct evidence that screening leads to improved vision, and there are no data on how it affects school performance.

The task force found that in kids between three and five years old, the benefits of screening would likely outweigh the harms.

Patching the good eye to allow sight in the lazy eye to develop led to a small increase in visual acuity over the short term.

The difference could be considerable for a kid and might translate into much greater benefits in the long run because lazy eye causes more and more vision loss if untreated, according to Calonge.

Patching the good eye or using eye drops led to only a small and reversible loss of visual acuity on that eye.

The American Academy of Ophthalmologists and other groups representing eye professionals said in a commentary in the same issue of the journal that they were “concerned” about the USPSTF’s new move.

They said eye examinations with an ophthalmoscope or newer technologies should be used regularly in infants to rule out serious eye diseases like cataracts that might lead to lazy eye.

Calonge said that he had not seen the commentary, but noted that “we deal in the realm of being able to say with moderate certainty that screening provides more benefits than harms.”

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Senator Wants To Ban ‘Bath Salt’ Drugs In The US

Senator Charles Schumer unveiled a bill on Sunday that would ban two drugs that produce a “meth-like” high and are being sold under the name “bath salts.”

“These so-called bath salts contain ingredients that are nothing more than legally sanctioned narcotics, and they are being sold cheaply to all comers, with no questions asked, at store counters around the country,” Schumer, a New York Democrat, said in a statement.

He said he will introduce a bill to outlaw the two synthetic drugs being marketed under names such as Ivory Snow, Red Dove and Vanilla Sky, which are ephedrine and methylenedioxypyrovalerone (MDPV).  The drugs come in powder and tablet form and are ingested by snorting, injection, smoking and by use of an atomizer.

According to the Drug Enforcement Administration (DEA), users experience an intense high, euphoria, extreme energy, hallucinations, insomnia and are easily provoked to anger.

They have emerged as legal alternatives to cocaine and methamphetamines, and one or both have already been banned in the European Union, Australia, Canada, and Israel.  The states Florida, Louisiana and North Dakota have all recently banned the substances.

“The longer we wait to ban the substance, the greater risk we put our kids in,” Schumer said.

Media reports last year said the drugs are becoming increasingly popular, particularly among young people attending nightclubs, although the actual number of individuals using the drugs is unknown.

“These products are readily available at convenience stores, discount tobacco outlets, gas stations, pawnshops, tattoo parlors, truck stops and other locations,” said an alert issued by the DEA.

“Prices range from $25 to $50 per 50-milligram packet,” the DEA alert said.

The EU banned mephedrone in December, saying the drug was directly linked to the deaths of two people, and may have been tied to 37 other cases of death.

The EU’s report said there was limited scientific evidence on the effects of the drug, but that there was sufficient evidence of its health risks to support a ban.

Schumer asked the health commission of New York State, Nirav Shah, to ban the substances as well.

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Delegates Discuss Work Burnout At World Economic Forum

Economic turmoil, round-the-clock communication and constant social pressure to succeed have led to a costly increase in stress-related illness and burnout, a panel of experts told a packed session in the Swiss ski resort of Davos.

“In the future, the greatest challenge to the global health system will be stress-related diseases,” said Heinz Schuepbach, director of the school of applied psychology at the University of Northwestern Switzerland. “The phenomenon is rapidly growing more prevalent,” he added.

According to a study this week by one of Germany’s top health insurance companies, one in five workers in Europe’s top economy has fallen ill from stress at work. In the last four years, sales of anti-depression drugs have risen by more than 40 percent in Germany, the study showed.

“There’s a new phenomenon. We’ve moved from absenteeism to presenteeism. People go to work even though they should stay at home because they are sick,” Schuepbach told AFP.

As burnout is not an “official” disease, concrete statistics on its spread are hard to come by, said Toni Bruehlamm, chief doctor at the Hohenegg clinic in Switzerland and an expert on the subject.  “We are never satisfied with what we’re doing. We have to do things faster, better,” he added.

“The economy is influencing society too much. Performance, money, all these factors have taken on too much importance. There’s simply too much emphasis on profits and money and it’s simply not healthy,” But it is definitely becoming more and more frequent. I see this from the number of people I see in my clinic and from what my colleagues tell me,” Bruehlamm told AFP.

The financial crisis, still a major topic at this year’s gathering, has contributed to global stress levels, with employees unwilling to take time off work even when they are ill for fear of being laid off.

Audience members tapped emails on their smart phones and others snoozed, Schuepbach blamed modern communications and a 24-hour-a-day working culture for the phenomenon. “Deadlines have to be met and it doesn’t even matter where you do your work anymore. I used to go home at 5pm and if my job wasn’t done, then that was fine. Now you can work around the clock,” he said.

With concerns about rising food prices, persistent fears over the environment and lingering worries about the debt crisis casting a pall over the annual pow-wow, organizer Klaus Schwab warned of a “global burnout syndrome.”

And the syndrome hits executives where it counts: in the pocket. According to the World Health Organization, the average burnout victim takes 30.4 days off work, costing billions to the economy. One top executive at Swiss food giant Nestle, Stephanie Pullings Hart, told AFP that the annual Davos meeting hardly helped to reduce the risk of burnout. “It’s my first Davos and it’s actually pretty exhausting,” she said.

“You start working at 7am and you’re not done until at least 2am by the time you’ve finished with the various receptions and parties. “How the world leaders cope with the stress is beyond me,” she said.

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Type 1 Diabetes: No More Insulin?

(Ivanhoe Newswire) — About 1 million people are affected by type 1 diabetes in the United States. According to a new study, type 1 diabetes could be converted to an asymptomatic, non-insulin dependent disorder by eliminating the actions of a specific hormone.

Type 1 diabetes is typically first diagnosed in children and teenagers. It is a disease where the body doesn’t produce insulin — a hormone that is needed to convert sugars, starches, and other food into energy.

Glucagon is a hormone secreted by the pancreas that prevents low blood sugar in healthy people. It causes high blood sugar in people with type 1 diabetes. The study done on mice suggests that insulin is unnecessary, and its absence doesn’t cause diabetes or any other abnormality when the actions of glucagon are suppressed, meaning that the elimination of glucagon action restores glucose tolerance to normal.

“We’ve all been brought up to think insulin is the all-powerful hormone without which life is impossible, but that isn’t the case,” Dr. Roger Unger, professor of internal medicine and senior author of the study, was quoted as saying. “If diabetes is defined as restoration of glucose homeostasis to normal, then this treatment can perhaps be considered very close to a ‘cure.’ “

Normally, glucagon is released when the glucose, or sugar, level in the blood is low. In insulin deficiency, however, glucagon levels are inappropriately high and cause the liver to release excessive amounts of glucose into the bloodstream. This action is opposed by insulin, which directs the body’s cells to remove sugar from the bloodstream.

In this study, UT Southwestern scientists tested how mice engineered to lack working glucagon receptors responded to an oral glucose tolerance test. The test measures the body’s ability to metabolize, or clear, glucose from the bloodstream.

The results showed that the mice with normal insulin production, but without functioning glucagon receptors, responded normally to the test. The mice also responded normally when their insulin-producing beta cells were destroyed. The mice had no insulin or glucagon action, but they did not develop diabetes.

“And if you don’t have glucagon, then you don’t need insulin,” Dr. Unger, who is also a physician at the Dallas VA Medical Center, was quoted as saying.

Dr. Young Lee, assistant professor of internal medicine at UT Southwestern and lead author of the study, said the next step is to determine the mechanism behind this result.

“Hopefully, these findings will someday help those with type 1 diabetes,” Dr. Lee said. “If we can find a way to block the actions of glucagon in humans, then maybe we can minimize the need for insulin therapy.”

“Matching the high insulin levels needed to reach glucagon cells with insulin injections is possible only with amounts that are excessive for other tissues,” Dr. Unger said. “Peripherally injected insulin cannot accurately duplicate the normal process by which the body produces and distributes insulin. If these latest findings were to work in humans, injected insulin would no longer be necessary for people with type 1 diabetes.”

SOURCE: Diabetes, published online January 26, 2011

3-D X-rays Unnecessary Radiation For Kids In Braces

Some orthodontists may be exposing young patients to unnecessary radiation when they order 3-D X-ray imaging for simple orthodontic cases before considering traditional 2-D imaging, suggests a paper published by University of Michigan faculty.

There is ongoing debate in the orthodontic community over if and when to use cone beam computed tomography (CBCT) for orthodontic diagnosis and treatment planning, said Dr. Sunil Kapila, lead author of the paper and chair of the Department of Orthodontics and Pediatric Dentistry at the U-M School of Dentistry.

A very small number of orthodontists utilize the 3-D imaging on a routine basis when developing a treatment plan, and this raises concerns of unnecessary radiation exposure. In contrast, the evidence summarized in Kapila’s paper suggests that 2-D imaging would suffice in most routine orthodontic cases. One of the tradeoffs for the superb 3-D images is higher radiation exposure, Kapila said.

The amount of radiation produced by 3D CBCT imaging varies substantially depending on the machine used and the field of view exposed, and some clinicians may not realize how much higher that radiation is compared to conventional radiographs. One CBCT image can emit 87 to 200 microsieverts or more compared to 4 to 40 microsieverts for an entire series of 2-D X-rays required for orthodontic diagnosis, Kapila said. Considering that the average US population is exposed to approximately 8 microsieverts of background radiation a day, 200 microsieverts equates to about 25 days worth of cosmic and terrestrial radiation.

“Most of the patients who need orthodontic treatment are young adults and pediatric patients,”said Dr. Erika Benavides, clinical assistant professor in U-M’s Department of Periodontics and Oral Medicine. Benavides is the board certified oral and maxillofacial radiologist who reads the CBCT scans taken at the U-M School of Dentistry. “Keeping in mind that the radiation received has cumulative effects, adding unnecessary radiation exposure to the patient may result in a higher biological risks, particularly in the more susceptible young children. This is why selecting the patients that would benefit the most from this additional exposure needs to be done on a case-by-case basis.”

Both Kapila and Benavides said when used judiciously, CBCT is an invaluable tool with a definite place in orthodontic treatment planning. The paper published by Kapila and his colleagues advocates “a balanced approach to utilizing CBCT in our patients,” Kapila said.

To that end, Kapila and colleagues reviewed the existing data on CBCT and found that this type of imaging is typically recommended in cases that include those with impacted teeth, temporomandibular joint disease, craniofacial abnormalities, and jaw deformities. While other patients could also benefit from 3D imaging, the decision to scan these patients should be made on a case-by-case basis after a clinical exam and evaluation of the specific patient needs, particularly when 2-D imaging has shown that addition 3-D information would result in a demonstrable benefit that would likely alter the treatment plan.

“There is nothing published on current usage patterns,” Kapila said. “Most of the information is anecdotal. Some clinicians and orthodontists are using this technology routinely, but I believe that most of those that use 3-D imaging use it fairly judiciously,” Kapila said.

The patients who are scanned at U-M Dental School are referred after clinical evaluation by dental specialists and the area to be scanned is carefully limited, Benavides said.

The paper, “The current status of cone beam computer tomography imaging in orthodontics,” was recently published in the journal of Dentomaxillofacial Radiology. Co-authors are R.S. Conley, associate professor at U-M School of Dentistry, and W.E. Harrell, both board certified orthodontists.

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Pre-surgical Stress Management Benefits Prostate Cancer Patients

UT MD Anderson study finds brief interventions may help speed physical and psychological healing

Practicing stress management techniques before prostate cancer surgery may help activate the body’s immune response leading to quicker recovery, as well as aid in lowering mood disturbance, according to a new study by researchers at The University of Texas MD Anderson Cancer Center.

The study is published in the February/March edition of the journal Psychosomatic Medicine. It’s the first to examine the effects pre-surgery stress management training has on immune outcomes in men with prostate cancer undergoing radical prostatectomy (surgical removal of the prostate). The researchers previously reported that men who received this training before surgery had significantly less mood disturbance and improved quality of life one year later.

Two levels of stress accompany surgery

“Men who face prostatectomy as treatment for prostate cancer often have high stress levels about the procedure and the potential effects on their quality of life,” said Lorenzo Cohen, Ph.D., the study’s senior author and professor in MD Anderson’s Departments of General Oncology and Behavioral Science. “Both the physical and psychological stress of surgery can be harmful to the immune system. Even brief pre-surgery sessions of stress management positively impact on the recovery process, both in terms of psychological and immunological outcomes,” he said.

Surgical stress causes a powerful inflammatory response close to the surgery site and throughout the body, raising certain cell-signaling proteins called cytokines that increase inflammation and suppress the immune response. Psychological stress dysregulates cytokine function, reduces the function of natural killer cells and slows wound healing.

While the elevation of inflammatory cytokines may be harmful if sustained, short-term increases before and after surgery may signal an immune response that helps wounds heal and recover.

Participants received different levels of intervention

In the study, 159 men with early-stage prostate cancer who were scheduled for radical prostatectomy were randomized into three groups.

  • Stress management (SM) group participants:
    • Met twice with a psychologist one to two weeks before surgery to discuss concerns and learned some cognitive techniques
    • Learned deep breathing and guided-imagery techniques to help cope with the possible effects of surgery
    • Were led through mental imagery to help prepare for surgery and hospitalization
    • Received a stress management guide that expanded on sessions and audiotapes of techniques to practice on their own
    • Had brief booster sessions with the psychologist on the morning of the surgery
    • Had a brief session 48 hours after surgery to reinforce relaxation and coping strategies
  • Supportive attention (SA) group participants:
    • Met twice with a psychologist one to two weeks before surgery. Sessions were supportive and included a semi-structured psychosocial and medical history in an interview format
    • Were provided empathy and an encouraging environment in which to discuss concerns
    • Had brief booster sessions the morning of surgery
    • Had a brief session 48 hours after surgery to discuss their experiences leading up to the surgery and during their hospital stay 
  • Standard Care (SC) received routine medical care and had no meetings with psychologists

Blood samples were collected from each patient about a month before surgery and 48 hours after surgery. Patient mood was measured about a month before surgery, a week before surgery (after the interventions) and the morning of the surgery.

Results show intervention benefits

Two days after surgery, the men in the SM group had:

  • Significantly higher levels of natural killer function and circulating pro-inflammatory cytokines than men in the SA group
  • Higher levels of natural killer function and the cytokine IL-1b than men in the SC group
  • Increased immune system parameters, which decreased or stayed the same for the other two groups

The SM group also had lower mood disturbances before surgery, but this was not found to be associated with immune outcomes.

“This study and evidence from other studies show that psychological intervention before an acute stressor can be beneficial to patients,” said Cohen, who is also director of the Integrative Medicine Program. “The implications are that managing stress has biological as well as psychological benefits and might have an effect on aspects of disease.”

Further, Cohen says, it suggests that it’s important to engage in some type of stress management during stressful periods, especially before surgery.

Next steps

Since the men who took part in this study were mostly white, non-Hispanic, married, and highly educated, researchers say additional studies are needed in more diverse populations, as well as men with advanced disease.

“We’re looking at targeting future research to people who might benefit the most, in particular those who are the most distressed and have the lowest level of social support,” Cohen said. “This will help provide the most benefit and effective use of health care system’s limited resources.”

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Moscow Shuts Down Schools After Flu Outbreak

Moscow and two other cities shut their schools down for a week Saturday in an attempt to stop the worst flu outbreak to hit central Russia in over a decade.

The Moscow education department’s order covered over 1,500 public and private elementary schools.  

Education officials said that this meant about 500,000 children would get an unscheduled week-long vacation in the first shutdown to strike the Russian capital since 1998.

“Even today, some classes are already missing half their students,” an official with Moscow’s health control service told the Komsomolskaya Pravda daily.

“The situation in Moscow is relatively favorable compared to what it is in the other regions” of central Russia, Alexander Gavrilov said.

The kindergarten schools would remain open and older children would not be affected.  However, officials have issued instruction for parents to take extra care of their younger children and have them avoid spending too much in public places

“Children should avoid gathering in large groups if they can be avoided,” Russia’s chief sanitary doctor Gennady Onishchenko told Interfax.

He also recommended that Moscow adopt “long-distance Internet learning” while schools are shut down.

The instructions were issued after schools reported empty classrooms due to the flu outbreak.

“A lot of our students our out. So it just made sense to close the schools instead of teaching three or four kids and then having everyone else catch up,” one Moscow school director told the Moskovsky Komsomolets newspaper.

Some education officials complained that Moscow schools were ill equipped to fight these outbreaks and that there was a general shortage of doctors on staff.

However, the city defended itself against this criticism and said outbreaks occasionally happen no matter what.

“We have vaccinated an entire 30 percent (of the Moscow population) against the regular flu,” the Kommersant business daily quoted the city’s chief sanitary official as saying.

“We are working — but we can provide no guarantees,” Nikolai Filatov said.

Officials said almost 92,000 Muscovites are currently inflicted with the flu.  Over 52,000 of them are children.

Officials said about 300 schools had already closed their doors across Russia by Friday evening.

New reports said that similar week-long closures had taken place in the industrial Ural city of Chelyabinsk and Russia’s northern Far East town of Yakutsk.

The outbreak was accompanied by new reports of the swine flu spreading through Moscow and other major cities.

There were 93 H1N1 infections, but no deaths were reported in Moscow.

On The Hunt For Universal Intelligence

We have developed an ‘anytime’ intelligence test, in other words a test that can be interrupted at any time, but that gives a more accurate idea of the intelligence of the test subject if there is a longer time available in which to carry it out”, Jos© Hernández-Orallo, a researcher at the Polytechnic University of Valencia (UPV), tells SINC.

This is just one of the many determining factors of the universal intelligence test. “The others are that it can be applied to any subject ““ whether biological or not ““ at any point in its development (child or adult, for example), for any system now or in the future, and with any level of intelligence or speed”, points out Hernández-Orallo.

The researcher, along with his colleague David L. Dowe of the Monash University, Clayton (Australia), have suggested the use of mathematical and computational concepts in order to encompass all these conditions. The study has been published in the journal Artificial Intelligence and forms part of the “Anytime Universal Intelligence” project, in which other scientists from the UPV and the Complutense University of Madrid are taking part.

The authors have used interactive exercises in settings with a difficulty level estimated by calculating the so-called ‘Kolmogorov complexity’ (they measure the number of computational resources needed to describe an object or a piece of information). This makes them different from traditional psychometric tests and artificial intelligence tests (Turing test).

Use in artificial intelligence

The most direct application of this study is in the field of artificial intelligence. Until now there has not been any way of checking whether current systems are more intelligent than the ones in use 20 years ago, “but the existence of tests with these characteristics may make it possible to systematically evaluate the progress of this discipline”, says Hernández-Orallo.

And what is even “more important” is that there were no theories or tools to evaluate and compare future intelligent systems that could demonstrate intelligence greater than human intelligence.

The implications of a universal intelligence test also impact on many other disciplines. This could have a significant impact on most cognitive sciences, since any discipline depends largely on the specific techniques and systems used in it and the mathematical basis that underpins it.

“The universal and unified evaluation of intelligence, be it human, non-human animal, artificial or extraterrestrial, has not been approached from a scientific viewpoint before, and this is a first step”, the researcher concludes.

References: Jos© Hernández-Orallo y David L. Dowe. “Measuring Universal Intelligence: Towards an Anytime Intelligence Test”. Artificial Intelligence 174(18): 1508, diciembre de 2010. DOI: 10.1016/j.artint.2010.09.006.

Image Caption: On the hunt for the universal intelligence test. Credit: SINC

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Taco Bell Refutes Filler Meat Claims

Taco Bell President Greg Creed spoke out on Thursday against a California woman’s class action lawsuit over his company’s taco meat filling, calling the suit “bogus and filled with completely inaccurate facts,” ABC News reported.

“There is no basis in fact or reality for this suit, and we will vigorously defend the quality of our products from frivolous and misleading claims such as this,” wrote Creed in a statement about the suit.

The lawsuit was filed on January 19 by the California law firms Blood, Hurst & O’Reardon and Beasley, Allen, Crow, Methvin, Portis & Miles on behalf of Amanda Obney.   The suit alleges that Taco Bell’s beef filling is 65 percent binders, extenders, preservatives, additives and other agents, and seeks to prevent the fast food chain from calling the filling “beef”.

However, Creed strongly disputes the claim.

“Our seasoned beef recipe contains 88 percent quality USDA-inspected beef and 12 percent seasonings, spices, water and other ingredients that provide taste, texture and moisture,” he said.

“The lawyers got their facts wrong. We take this attack on our quality very seriously and plan to take legal action against them for making false statements about our products.”

Creed said Taco Bell uses a proprietary recipe that adds flavor and texture to its seasoned beef, “just like you would with any recipe you cook at home.”

The final product contains 3 to 5 percent water for moisture, 3 to 5 percent spices, and 3 to 5 percent oats, starch, sugar, yeast, citric acid, and other ingredients you’d find at home or in the supermarket, he said.

“Our seasoned beef contains no ‘extenders’ to add volume, as some might use.”

Obney’s lawsuit has generated considerable media attention, something Creed said his company takes seriously.

“We take this attack on our quality very seriously and plan to take legal action against them for making false statements about our products,” Creed said.

However, the law firm that filed the suit maintains its position that Taco Bell is misrepresenting its product.

“We are disappointed that Taco Bell chooses to repeat its false statements rather than simply tell the truth,” ABC news cited Timothy Blood, a lawyer with Blood, Hurst &
O’Reardon LLP, as saying.

“Food additives such as isolated oat product, wheat oats, soy lecithin, maltodrextrin, anti-dusting agents, autolyzed yeast extract, modified corn starch and sodium phosphate are neither beef nor spices.”

Blood said the law firm has received numerous e-mails and calls since filing the suit from Taco Bell customers who reported suffering “severe allergic reactions from eating the food additives in Taco Bell’s beef-flavored food products.”

“We urge Taco Bell to be at least as interested in the well-being of its customers as it is in marketing, public relations and profit,” Blood said.

A full list of Taco Bell’s ingredients can be viewed at the company’s Web site.

Depression Can Be Caused By Unhealthy Eating

According to a Spanish study published Wednesday, eating “junk foods” – foods with high levels of trans-fats and saturated fats – increases the risk of depression confirming previous studies.

Researchers also showed that some products, such as olive oil, which is high in healthy omega-9 fatty acids, can fight against the risk of mental illness.

Authors of the wide-reaching study, from the Universities of Navarra and Las Palmas de Gran Canaria, followed and analyzed the diet and lifestyle of over 12,000 volunteers over six years. When the study began, none of the participants had been diagnosed with depression; by the end, 657 of them were new sufferers.

“Participants with an elevated consumption of trans-fats (fats present in artificial form in industrially-produced pastries and fast food…) presented up to a 48 percent increase in the risk of depression when they were compared to participants who did not consume these fats,” the head study author said in a statement.

Almudena Sanchez-Villegas, associate professor of preventive medicine at the University of Las Palmas de Gran Canaria, also noted that in the event “more trans-fats were consumed, the greater the harmful effect they produced in the volunteers.”

The research team found, at the same time, that after assessing the impact of polyunsaturated fats — composed of larger amounts of fish and vegetable oils — and olive oil, these products “are associated with a lower risk of suffering depression.”

Thus, the results of the study corroborate the hypothesis of a greater incidence of the disease in countries of the north of Europe compared to the countries of the south, where a Mediterranean dietary pattern prevails. Nevertheless, experts have noted that the incidence of the disease has increased in recent years, so that today some 150 million persons are affected worldwide, where it is the principal cause of loss of years of life in those countries with a medium-to-high per capita income.

This due, according to Almudena Sánchez Villegas, “to radical changes in the sources of fats consumed in Western diets, where we have substituted certain types of beneficial fats””polyunsaturated and monounsaturated in nuts, vegetable oils and fish””for the saturated and trans-fats found in meats, butter and other products such as mass-produced pastries and fast food”.

In addition, the research “” published in the online peer reviewed journal PLoS ONE “” has been performed on a population with a low average intake of trans-fats, given that it made up only 0.4% of the total energy ingested by the volunteers. “Despite this, we observed an increase in the risk of suffering depression of nearly 50%. On this basis,” concluded Miguel A. Martínez, “we derive the importance of taking this effect into account in countries like the US, where the percentage of energy derived from these foots is around 2.5%”.

Finally, the analysis suggests that both depression as well as cardiovascular disease are influenced in a similar manner by diet, and might share similar mechanisms in their origin. This hypothesis is further suggested by numerous studies that indicate the harmful effect of trans-fats and saturated fats on the risk of cardiovascular disease.

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Consumer Watchdog Blasts Google’s Schmidt

Consumer Watchdog, an advocacy group that has focused much of its attention in recent years on Google’s privacy practices, debuted its new animated satire — “Mr. Schmidt Goes to Washington” — on the streets of Washington DC, as part of its case for why Congress should call Google CEO Eric Schmidt to testify under oath about the Wi-Spy scandal and other online privacy issues, and also said the company’s close ties to the National Security Agency should be investigated.

The animation is being shown on a mobile digital advertising truck equipped with stereo sound that will travel for one week across Capitol Hill, downtown, and through busy District thoroughfares. The animation shows Google’s CEO testifying before Congress using real-life, creepy quotes from Schmidt about privacy to make the case for why Congress should question him.

The advocacy group, in a letter sent out Monday, also asked Representative Darrell Issa, the new chairman of the House Oversight and Government Reform Committee, to investigate the relationship between Google and several government agencies.

In the letter, the group asks Issa to investigate contracts at several US agencies for Google technology and services, the “secretive” relationship between Google and the NSA, and the company’s use of a NASA airfield in California.

Federal agencies have also taken “insufficient” action in response to revelations last year that Google Street View cars were collecting data from open Wi-Fi connections they passed, Consumer Watchdog said in the letter.

“We believe Google has inappropriately benefited from close ties to the administration,” the letter said. “Google is most consumers’ gateway to the Internet. Nonetheless, it should not get special treatment and access because of a special relationship with the administration.”

Consumer Watchdog may have luck with Issa. In July, he sent a letter to Google raising concerns that White House Deputy Chief Technology Officer Andrew McLaughlin, former head of global public policy for Google, had inappropriate email contact with company employees.

A spokesperson for Google questioned Consumer Watchdog’s objectivity. Some groups have questioned the group’s ties to Microsoft, and its criticisms of online privacy efforts have also zeroed in on Google, with the group rarely mentioning other sites, including Microsoft, Facebook, and other Web-based companies in the past two years.

“This is just the latest in a long list of press stunts from an organization that admits to working closely with our competitors,” said the Google spokesperson according to PC World.

But Consumer Watchdog receives no funding from Microsoft or any other competitor of Google, John Simpson, consumer advocate with the group, told PC World. “We don’t have any relationship with Microsoft at all “¦ We don’t take any of their money,” he said.

Simpson said the group has decided to focus on Google’s privacy practices because the company’s services serve as a gateway to the Internet for many people. If the group can push Google, “without a doubt the dominant Internet company,” to change its privacy practices, other companies will follow suit, he said.

“Google’s held itself to be the company that says its motto is, ‘don’t be evil,’ and they also advocate openness for everyone else,” said Simpson. “We’re trying to hold them to their own word.”

In January 2009, Consumer Watchdog claimed that Google was trying to get Congress to allow the sale of electronic health records. Google said those allegations were “100 percent false and unfounded.”

In September, the advocacy group bought space on a 540-square-foot video screen in New York’s Times Square, showing a video criticizing Google’s privacy practices. That video, titled “Don’t be evil?,” got about 400,000 views since its Superscreen debut.

In April, advocacy officials called for the US Department of Justice to break up Google. They appeared at a press conference with a representative of the Microsoft- and Amazon-funded Open Book Alliance.

Consumer Watchdog’s latest complaints about the relationship of Google and the Obama administration are outlined in a 32-page report.

The report questions a decision by NASA allowing Google executives to use its Moffett Federal Airfield near Google headquarters. Although H211, a company controlled by Google top executives, pays NASA rent, they enjoy access to the airfield that other companies or groups don’t have, Simpson said.

The paper also questions Google contracts with the US Department of Defense and other federal agencies, suggesting that, in some cases, Google contracts were fast-tracked. It also questions Google’s relationship with the NSA and calls for the company to be more open about what consumer information is shares with the spy agency.

“I understand the NSA is a super-secret spook organization,” he said. “But given Google’s very special situation where it possesses so much personal data about people, I think that there ought to be a little more openness about what precisely goes on between the two.”

“Google spent $5.2 million lobbying last year ““ up from $4.03 million in 2009 ““ to convince Congress that nothing is wrong. The company has repeatedly refused to answer questions about its activities ““ making no response to Consumer Watchdog reports, rejecting multiple invitations appear at our recent privacy conference with officials representing the Federal Trade Commission and Commerce Department, and even failing to comply with a subpoena by the state attorneys general,” said Simpson. “Clearly Google’s executives won’t answer tough questions until they come from Congress.”

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Mosquitoes Released In Malaysia To Help Fight Dengue Fever

There is a new player in the fight against dengue fever in Malaysia, 6,000 of them actually.

Malaysia released about 6,000 genetically modified mosquitoes into a forest in the first experiment of its kind in Asia aimed at curbing dengue fever, officials said Wednesday to AP.

The field test is meant to pave the way for the use of genetically engineered Aedes aegypti male mosquitoes to mate with females and produce no offspring or ones with shorter lives, hopefully curtailing the mosquito population. Only female Aedes aegypti mosquitoes spread dengue fever, which killed 134 people in Malaysia last year.

The plan has sparked criticism by some Malaysian environmentalists, who fear it might have unforeseen consequences, such as the inadvertent creation of uncontrollable mutated mosquitoes. Government authorities have tried to allay the concerns by saying they are conducting small-scale research and will not rush into any widespread release of mosquitoes.

The Malaysian government-run Institute for Medical Research said it released about 6,000 sterile male lab mosquitoes in an uninhabited forest area in eastern Malaysia on Dec. 21. Another 6,000 wild male Aedes aegypti mosquitoes were also placed in the area for scientific comparison, it said in a statement.

The institute provided few details of the experiment, but said it was “successfully” concluded Jan. 5, and that all the mosquitoes were killed with insecticide. It was the first such trial in Asia, an official for the Ministry of Natural Resources and Environment said on condition of anonymity because he was not authorized to make public statements.

A similar trial in the Cayman Islands last year “” the first time genetically modified mosquitoes have been set loose in the wild after years of laboratory experiments and hypothetical calculations “” resulted in a dramatic drop in the mosquito population in a small area studied by researchers.

Genetically altered sterile male mosquitoes were also set loose by scientists in a 40-acre region between May and October last year in the Cayman islands. By August, mosquito numbers in that area dropped by 80 percent compared with a neighboring area where no sterile mosquitoes were released.

Duane Gubler, a professor specializing in infectious diseases at Singapore’s Duke-NUS Graduate Medical School who was not involved with the research, said the plan is likely to be effective in fighting dengue if it is combined with other biological control methods. “We need new tools. Nothing we’ve done in the past 40 years has had an impact” on dengue, Gubler told the AP.

Dengue fever is common in Asia and Latin America. Symptoms include high fever, joint pains and nausea, but in severe cases, it can lead to internal bleeding, circulatory shutdown and death. There is no known cure or vaccine.

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