High Blood Pressure Linked To Sex, Race, And Geography

(Ivanhoe Newswire) — Incidence of high blood pressure may help to explain why deaths from heart disease and stroke vary according to geography, race, and sex, according to this study.

“Where you live, your race, and your gender strongly influence your risk of developing high blood pressure as you move from young adulthood into middle age “” and hypertension is a major risk factor for heart disease and stroke,” Deborah A. Levine, M.D., M.P.H., lead study author and assistant professor of internal medicine in the Departments of Medicine and Neurology at the University of Michigan Medical School in Ann Arbor was quoted as saying.

Between 1968 and 2006, deaths from heart disease and stroke fell an enormous 65 percent, but everyone didn’t share equally in the positive trend. Cardiovascular deaths are still higher in the southeastern United States, in blacks compared with whites, and in men compared with women.

“The gaps may be widening, particularly for blacks,” Levine said. “The reasons for the variations are not clear, so we examined whether high blood pressure might help to explain it.”

The researchers examined data from the Coronary Artery Risk Development in Young Adults (CARDIA) study that followed young people from Birmingham, Ala., Chicago, Ill., Minneapolis, Minn. and Oakland, Calif., from the time they were 18-30 years old. Each center began the study with groups similar to each other for race, sex, and age. Among 3,436 participants who didn’t have high blood pressure when the research began, and were followed for 20 years (when average age was 45).

Hypertension was diagnosed in 37.6 percent of black women; 34.5 percent of black men; 21.4 percent of white men and 12.3 percent of white women; 33.6 percent of Birmingham residents; 27.4 percent in Oakland; 23.4 percent in Chicago and 19 percent in Minneapolis.
After adjusting for multiple risk factors, living in Birmingham significantly increased the chance that a person would develop high blood pressure.

“In addition, independently of where they live, blacks “” especially black women “” are at markedly higher risk of hypertension even after we took into account factors that are known to affect blood pressure, such as physical activity and obesity,” Levine said.

More research is needed to understand the geographic and racial differences in high blood pressure documented in this study as well as the potential biological, environmental and genetic mechanisms, Levine said. “In the meantime, people at higher risk can benefit from close monitoring of their blood pressure and paying attention to risk factors such as obesity and physical activity.”

SOURCE: Hypertension: Journal of the American Heart Association, published online December 6, 2010

Using New Materials To Make More Reliable Nanoelectromechanical Systems

Given their outstanding mechanical and electrical properties, carbon nanotubes are attractive building blocks for next-generation nanoelectromechanical devices, including high-performance sensors, logic devices, and memory elements.  However, manufacturing challenges associated with creating well-ordered arrays of individual carbon nanotubes and the nanotube-devices’ prevalent failure modes have prevented any large-scale commercial use.

Now, researchers at Northwestern University, the Center for Integrated Nanotechnologies at Sandia and Los Alamos National Laboratories, and Binghamton University have found a way to dramatically improve the reliability of carbon nanotube-based nanoelectromechanical systems. Their results are published in the journal Small.

“Depending on their geometry, these devices have a tendency to stick shut, burn or fracture after only a few cycles,” said Horacio Espinosa, James N. and Nancy J. Professor in the McCormick School of Engineering at Northwestern University.  “This significantly limits any practical application of such nano devices. Our discovery may be a key to advancing carbon nanotube-based nanoelectromechanical systems from laboratory-scale demonstrations to viable and attractive alternatives to many of our current microelectronic devices.”

To date, carbon nanotube-based nanoelectromechanical devices have ubiquitously used metal, thin-film electrodes. The Northwestern University group in collaboration with SANDIA investigators replaced these electrodes with electrodes made from diamond-like carbon (an electrically-conductive and mechanical robust material), which suppressed the onset of failure. This enabled them to demonstrate the first example of nanoelectromechanical devices constructed from individual CNTs switching reliably over numerous cycles and apply this functionality to memory elements that store binary states.

“This represents a significant step in the maturation of carbon nanotube-based device technology,” Espinosa said.

The team used a carbon nanotube-based nanoelectromechanical switch as a platform to study failure modes and investigate potential solutions.

“This switch shares operating principles, and thus failure modes, with numerous reported devices,” said Owen Loh, a graduate student in Espinosa’s lab.  “In this way, we hope the results will be broadly applicable.”

First, the team conducted a parametric study of the design space of devices using conventional metal electrodes. This enabled identification of the point of onset of the various failure modes within the design space and highlighted the highly limited region in which the devices would function reliably without failure. They then used computational models to explain the underlying mechanisms for the experimentally-observed modes of failure.

“Using these models, we can replicate the geometry of the devices tested and ultimately explain why they fail,” said Xiaoding Wei, a post-doctoral fellow in Espinosa’s lab.

The team then demonstrated that using alternative electrode materials like diamond-like carbon could greatly improve the reliability of these devices. They repeated a similar parametric study using diamond-like carbon electrodes rather than metal thin films and found a dramatic improvement in device robustness. This enabled reliable switching of the carbon nanotube-based devices through numerous cycles, as well as application to the volatile storage of binary “0” and “1” states.

Other co-authors of the paper include Changhong Ke and John Sullivan.

This work was supported by the Army Research Office and National Science Foundation, and was performed in part at the Center for Integrated Nanotechnologies, a U.S. Department of Energy facility at Los Alamos National laboratory and Sandia National Laboratories, and in part at the Center for Nanoscale Materials.

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US Scores 25 Out Of 34 In Mathematics

According to a report released Tuesday by the U.S. Education Department, 15-year-old students in the U.S. performed below average in mathematics compared to other industrialized nations.

China, Finland and Korea won the highest scores based on how well students apply their knowledge in math, science and reading.

“While not representative of all of China, this is sure to send shock waves through the U.S. and Europe as it’s yet another sign of China’s rising dominance,” Michael Petrilli of the Thomas B. Fordham Institute told CNN news.

Fifteen-year-old students in the U.S. performed average in reading and science, and below average in math.  The U.S. ranked 14th in reading, 17th in science and 25th in math.

“This is an absolute wake-up call for America,” U.S. Education Secretary Arne Duncan told the Associated Press. “The results are extraordinarily challenging to us and we have to deal with the brutal truth. We have to get much more serious about investing in education.”

U.S. students have still improved since the 2006 Program for International Student Assessment.

“Relative to other countries, the United States is decidedly weaker in mathematics than in reading or even science, although there is evidence that the U.S. is making progress relative to similarly performing countries,” National Center of Education Sciences Deputy Commissioner Stuart Kerachsky said in a news release.

Girls scored better than boys in reading literacy in all participating countries and education entities.

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Taking Low Dose Aspirin Daily Can Help Combat Cancer

Researchers at Oxford University and other British institutes have found that taking low-dose aspirin on a daily basis can help reduce the risk of cancer by 20 percent.

“Daily aspirin reduced deaths due to several common cancers during and after the trials,” the researchers wrote in The Lancet on Tuesday. “Benefit increased with duration of treatment and was consistent across the different study populations. These findings have implications for guidelines on use of aspirin and for understanding of carcinogenesis and its susceptibility to drug intervention.”

While the trial focused on colorectal cancer, showing that taking aspirin for at least five years reduces the risk of the disease, Oxford Professor Peter Rothwell and his the research team noted that “several lines of evidence suggest that aspirin might also reduce risk of other cancers, particularly of the gastrointestinal tract” but that there was no concrete proof that those claims were valid.

Rothwell and his colleagues conducted eight separate trials with more than 25,000 total subjects, and found that the fatality rate for certain types of cancer could be reduced by as much as one-fifth by consuming low-dose aspirin. According to AFP reporter Marlowe Hood, the studies ranged in length from four to eight years and included doses as low as 75 milligrams.

“These are very exciting and potentially important findings,” London School of Hygiene & Tropical Medicine (LSHTM) Professor Tom Meade, who worked on the study while a member of the Medical Research Council, said in a statement Monday. “They are likely to alter clinical and public health advice about low dose aspirin because the balance between benefit and bleeding has probably been altered towards using it.”

“Previous guidelines have rightly cautioned that in healthy middle-aged people the small risk of bleeding on aspirin partly offsets the benefit from prevention of strokes and heart attacks, but the reductions in deaths due to several common cancers will now alter this balance for many people,” Rothwell added in an interview with Reuters Health and Science Correspondent Kate Kelland Tuesday.

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What Makes Married Men Behave Better?

According to a new study, men tend to behave better once they get married, for at least a few possible reasons: for one, marriage likely helps improve their behavior, and two, nicer men are more likely to be married in the first place.

The researchers found that men with fewer bad behavioral qualities were more likely to eventually become married. But among men who did marry, some showed signs that indicated their bad behavior decreased after they tied the knot.

The findings address a long-running debate among researchers, concerning why married men display fewer qualities associated with antisocial personality disorder, such as lying, aggression, lack of remorse, and even criminal behavior.

The question: Is it because marriage reforms them, or because men with more of these nasty traits are not as likely to get married in the first place?

The answer: Some of both, study author Dr. S. Alexandra Burt at Michigan State University told Reuters Health. Married men are usually “not as antisocial to begin with,” she said. “And when they get married, they get even less antisocial. So both things are going on.”

For the study, Burt and her colleagues followed 289 pairs of male twins for 12 years, between the ages of 17 and 29, and were assessed four times: at ages 17, 20, 24 and 29. More than half of the twins were identical, meaning they shared all of their genes, and also, for the most part, their childhood environment.

The team found that men who eventually married during the study period — roughly 60 percent of them — showed less antisocial behavior at ages 17 and 20, suggesting that men with more of these traits are less likely to get married in the first place.

They found that by the age of 29, unmarried men had an average of 1.3 antisocial behaviors, compared with 0.8 percent of married men.

And in the identical twins, in which one was married and one was not, the married twin had fewer antisocial behaviors after marriage than the unmarried twin. Given that identical twins are likely to have the same antisocial behavioral traits, the findings indicate that marriage helped weed out those bad behaviors.

“Not everyone is equally likely to enter the institution of marriage,” Dr. Ryan King at the University at Albany, SUNY, who was not involved in the study, told Reuters. “But those that do enter into it get some benefit from it.”

It is not really clear why men’s behaviors might improve after marriage, King noted. Married men may spend more time with their wives than with their friends, he said, and many bad behaviors, such as delinquency and binge drinking tend to be group activities. Also, married men “have more to lose” if they are caught doing illegal activities, and may worry what their spouses would think.

It is also unclear why men with more bad behaviors may not marry in the first place, Burt said. They probably do not make the most eligible bachelors, she noted. “You may not be looking to settle down with someone who’s prone to aggression, theft, and other things.” And for men with these tendencies, marriage may not be so appealing to women, she added.

The findings help to explain the consistent findings from other studies that men who are married commit fewer crimes. Another recent study showed marriage was associated with a 35 percent reduction in crime.

Other studies have also found that married people as a group tend to be healthier than singles — though more recent research suggests such health advantages of marriage may be fading. Still, people with spouses tend to live longer, be less depressed, and suffer less from heart disease and stroke.

The results of the study were presented in the Archives of General Psychiatry. Burt’s co-researchers for the study were M. Brent Donnellan and Mikhila Humbad from MSU; Brian Hicks from the University of Michigan; and Matt McGue and William Iacono from the University of Minnesota.

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Man Has Camera Implanted In His Head For Exhibit

A New York University professor has had a camera surgically implanted in the back of his head as part of a new art exhibit.

Iraqi-born Wafaa Bilal, a photography professor at NYU’s Tisch School of the Arts, told CNN on Thursday that the purpose of “The 3rd I” project is to expose the unspoken conditions that humans face.

“A project like this is meant to establish a dialogue about surveillance,” said Bilal, who had the thumb-sized camera implanted at a piercing studio last month.

The device was mounted on a titanium plate inserted inside the back of his head, Bilal said.

A cable runs from the camera in Bilal’s head to a computer he carries with him in a customized shoulder bag, providing a real-time global positioning signal of his location.

The data can be viewed in real-time on the project’s website at www.3rdi.me.

The camera will take photographs each minute during Bilal’s everyday activities for one year, he said.  The images will then be transmitted to the Arab Museum of Modern Art, in Doha, Qatar.

A statement by the museum said the exhibit, entitled “Told/Untold/Retold”, would be unveiled in time for the museum’s December 30 opening.

“I wanted to lose that subjectivity [of knowingly taking photographs],” Bilal told CNN.

“At the same time I wanted to capture everyday mundane images.”

The project has raised privacy concerns about the constant presence of cameras in Bilal’s classroom, which University authorities sought to dispel by requiring a cover over the lens while Bilal is teaching.

“We place a high value on his right to free expression in his creative work as an artist,” CNN quoted university spokesman John Beckman as saying.

“But as a school of the arts, we also take seriously the privacy issues his project raises.”

“The 3rd I” is not Bilal’s first involvement with controversial and unusual ventures.  A 2007 project called “Domestic Tension” allowed virtual users to hurl paintballs at him in an exhibit that drove The Chicago Tribune to name Bilal artist of the year.

The project was “one of the sharpest works of political art to be seen in a long time,” the newspaper said.

Bilal has said he seeks to examine broader ideas and realities through his art.

“I see myself as a mirror reflecting some of the social conditions that we ignore.”

Scientists Untangle Spider Web Stickiness

Studying spider silk, NSF-supported researchers learn about the properties of this sticky material, and their findings could lead to new bio-adhesives and glues that work under water

Ali Dhinojwala and Vasav Sahni consider themselves materials scientists, not biologists. They study surfaces, friction and adhesion. Nevertheless, they have discovered that understanding how nature makes things stick sometimes means getting up close and personal with the creatures responsible.

When they recognized, for example, the stickiness of spider silk, “we thought there’d be nothing sexier than working in this area,” Sahni said. “Little did I realize that working with spider silk meant working with spiders, too. Big, scary spiders.”

Making fresh samples “involved working with newly-spun spider webs in which the spider would be waiting for its prey,” he added. “Then I was informed that the spiders I am working with are non-poisonous, which calmed me down a little.”

Anyone who comes into direct contact with a spider web knows how sticky it is, the result of a glue-like substance the spider produces from one of the glands in its stomach. But, until recently, scientists did not understand how the glue behaved.

Dhinojwala, a professor and chair of the department of polymer science at the University of Akron in Ohio, and Sahni, a doctoral candidate there, joined with Todd Blackledge, professor of biology, to try to figure out the properties of the microscopic substance that orb-weaving spiders deposit along the round rings of silk they spin as part of their webs. Those droplets–three times thinner than the diameter of a single hair–capture the flies and other insects that spiders eat.

“It’s not just the stickiness,” Dhinojwala said. “We wanted to better understand the adhesion–how elastic is it? How stretchy is it? The objective was not to determine what it was made up of, but how it behaves and why is it so sticky?”

The drops are composed of highly entangled polymers, which are physically or chemically cross-linked and transmit forces very efficiently. Under a microscope, the researchers pulled on individual glue drops while measuring their force-extension behavior–not easy to do using a tiny probe.

They found the material to be both viscous and elastic, valuable properties for catching fast-flying, incoming insects–and in keeping the victims trapped long enough for the spider to subdue, and devour, them.

The material’s consistency is not quite liquid, nor like honey, nor even like silly putty. “It feels like chewing gum,” Dhinojwala said. “It just keeps stretching and stretching.”

It is also water resistant, a useful feature since spiders work in humid conditions, including rain. In fact, the material loses its stickiness without moisture, “unlike scotch tape, which isn’t sticky anymore once you put water on it,” Dhinojwala said. “This glue needs water to be sticky.”

The researchers hope the data will have important practical applications in developing new bio-adhesives, particularly in bandages and other products that must retain their stickiness when in contact with water. “Sometimes you want your bandages to work under water,” Dhinojwala said. “Also, there are quite a number of times we want to attach things under water. Water is always a problem with adhesives. But this can hold under water.”

The researchers studied only orb-weaving spiders, which are commonly found in trees and grasses. As their name suggests, they spin an orb-like web–that is, a web in the shape of a circle, with spokes and rings.

The spiders use different glands in their stomachs to secrete proteins that make up the web. The thread of the spokes–which provides the web’s strength–come from a gland known as the major ampullate. Each spider has two of these.

“That thread is well-known for its strength,” Dhinojwala said. “It supports a lot of weight. By weight, that silk is stronger than steel.”

Sahni recalls the day the researchers tried to find something synthetic that could compare to the properties of spider silk. “Needless to say, we failed,” he said.

The circles–where the glue is deposited–come from the minor ampullate gland. Each spider has two of these as well.

“The material is called spiral silk and its purpose is to catch insects, so it is sticky,” Dhinojwala said. “If you look at spiral silk under a microscope, you will see these little drops–the glue.” The drops come from yet another gland, known as the aggregate gland. Each spider has four of these.

Once Sahni overcame his fear, he went off on field trips to hunt spiders for the experiments. “Field trips to hunt spiders to bring to our lab, going to nature preserves, etc., was something which I, a non-biologist, was never exposed to, and hence, enjoyed it a lot,” he said.

“When Vasav came here, he had no clue he would be working with spiders,” Dhinojwala added. “He came to work with polymers. He was really scared of spiders–he’d never touched one or handled one. His instinct was to run away. Now he goes under the bridge and catches them. He’s a curious guy, and his curiosity overtook his fear.”

Essentially, the spiders spun their webs in a box in the lab “and we collected the samples,” Dhinojwala said. “We put the spider web in a glass plate, and used a tiny probe to poke it and measure how much force was required to pull it off. We tested the strength and the elasticity–not just its sticking power, but how elastic and stretchy it was, which is critical for stickiness, and the major crux of understanding the adhesion.”

The National Science Foundation (NSF) funded the work, and the findings appeared recently in the journal Nature Communications.

Dhinojwala and his colleagues have long been interested in how nature produces its own adhesives. The University of Akron professor has studied how the gecko lizard can stick to surfaces without any glue-like substance, and currently is creating synthetic material inspired by his gecko research. “We designed tapes without glue based on what we learned from the geckos,” he said.

“What the spider does is evolution at its finest,” he added. “They have survived by using nature effectively. The more we learn of how nature uses these materials, the better position we will be in to take advantage of this and design things based on what we learn.”

Sahni agrees. “We non-biologists get totally excited even now when we see a spider spinning a web, or when we see it catching its prey,” he said. “This interest and fascination with this field prompts us to ask the whys and hows to just about everything.”

By Marlene Cimons, NSF

Image Caption: Researchers are trying to figure out the properties of the glue-like substance that spiders deposit along the rings of silk in their webs that give the web its stickiness. Here, a banded garden spider, one type of orb weaver used in the study, waits for prey to become entangled in its web. Credit: Allison Hazen

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US Lags Behind Safeguarding Against Cyberattacks

Experts say that it will take several more years for the government to fully install high-tech systems to block cyber-attacks, which is a drawn-out timeline that enables criminals to become better at stealing sensitive data.

Experts suggest that technology already may be passing Department of Homeland Security moves to secure approximately 2,400 network connections used every day by millions of federal workers around the globe.

The department that is responsible for securing government systems other than military sites is slowly moving all the government’s’ Internet and e-mail traffic into secure networks that eventually will be guarded by intrusion detection and prevention programs. 

However, progress has been slow and officials are trying to complete complex contracts with network vendors, work out technology issues and address privacy concerns that involve how monitoring affects employees and public citizens.

“This is a continuing arms race and we’re still way behind,” Stewart Baker, former Homeland Security undersecretary for policy, told the Associated Press (AP).

WikiLeaks releasing over a quarter-million sensitive U.S. documents highlights the coming challenges.  Officials believe an Army intelligence analyst who downloaded them onto a CD stole the sensitive documents from secure Pentagon computer networks.

The changes sought by Homeland Security on the government’s nonmilitary computers would be wider and more systemic than the immediate improvements ordered recently by the Department of Defense and State as a result of the WikiLeaks releases.

“There are very few private sector actors who depend on information security who think that installing intrusion prevention systems is sufficient protection against the kinds of attacks that we’re seeing,” Baker said.

Navy Rear Admiral Michael Brown, Homeland Security’s director for cybersecurity coordination, told AP that over half of the government’s 2,400 network connections are already protected by an automated system that monitors federal Internet and e-mail traffic for malicious activity.

However these cover fewer than 20 of the 110 federal agencies.

The automated system, also known as Einstein 2, is installed and working at 13 of the 19 agencies that plan to police their own networks.  Brown said the remaining 91 departments will go through one of four major communications companies for the monitoring.

All network traffic will eventually flow through 72 sites called Trusted Internet Connections, including eight operated by the four communications companies and 64 operated by individual agencies.

Brown said that a more sophisticated system known as Einstein 3 will detect and automatically block intrusions.  He said that it has just completed testing and will take several years to fully be implemented.

Brown insisted that the government is not lagging behind private industry in its efforts to secure computer networks.  He also said that each agency is responsible for setting up safe cybersecurity practices. 

Criminals these days “are more targeted, are more professional, and have greater sophistication and capabilities,” he said.

Jerry Dixon, former director at Homeland Security’s Computer Emergency Readiness Team, told AP that Einstein will add a valuable safeguard to government agencies but “there still is not a magic bullet” to defeat the increasingly sophisticated threats.

“We’re always playing catch-up or reacting to the last major cyberincident or event but not doing a lot to think about what the future might hold,” said Dixon, who is now director of analysis at the Internet security firm Team Cymru.

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Wikileaks Continues Distributing Documents

As Washington continued to turn up the heat on Wikileaks and founder Julian Assange over the weekend, the confidential information distributed by the website remained available through mirror sites and torrent peer-to-peer sharing programs, the AFP reported Sunday.

After losing the support of many of its partners in the United States, including website host Amazon.com and content distributor Tableau Software, and becoming the target of numerous cyberattacks late last week, Wikileaks “has already been forced to change its domain name and hop-scotch to servers around the globe,” the French news agency said.

According to AFP, “Wikileaks has been offering its archives for download through torrent peer-to-peer sharing–a move that could allow any user around the world to post them or share them”¦ Anticipating the US attempts to block it though, Wikileaks has taken the precaution of posting a big, 1.4-gigabyte file encrypted with a 256-digit key said to be unbreakable.”

The file, which the news organization identified as ‘insurance.aes256,’ is “big enough to contain all the US cables said to be in Wikileaks’s possession,” including all of the 250,000 cables released to date as well as all of its previously published documents pertaining to the Iraqi and Afghanistan wars. The data is unreadable until a key is provided.

“Due to recent attacks on our infrastructure, we’ve decided to make sure everyone can reach our content,” Wikileaks said in a message posted to its site, the AFP reported. “As part of this process we’re releasing archived copy of all files we ever released,” Wikileaks said in a message on its site.”

In an interview with the UK newspaper The Guardian on Friday, Assange said that the cable archives had been “spread, along with significant material from the US and other countries to over 100,000 people in encrypted form,” as well as several news media outlets. “If something happens to us, the key parts will be released automatically”¦ History will win.”

Assange’s whereabouts have also become a source of speculation. According to the AFP, the 39-year-old Australian said that he was no longer welcome in his home country, who has vowed to support the American government in its battle against Wikileaks.

According to Associated Press (AP) writer John Heilprin, Assange “is considering seeking asylum in Switzerland” after telling a Spanish newspaper that he had been targeted by “hundreds” of death threats, including some targeting his children and Wikileaks lawyers.

Heilprin notes that Assange “had begun seeking donations to an account under his name through the Swiss postal system in Bern, the Swiss capital, while also using a Swiss-Icelandic credit card processing center and other accounts in Iceland and Germany. He lost a major source of revenue when the online payment service provider PayPal cut off the Wikileaks account over the weekend.”

The AP said that he was currently in Britain, citing Assange’s UK lawyer as a source.

Meanwhile, in the United States, government officials worked to try to undo the damage done by the published documents. On Monday morning, the website of British media outlet The Independent reported that the US was “being forced to undertake a major reshuffle of the embassy staff, military personnel and intelligence operatives whose work has been laid bare” by the Wikileaks cable leaks.

“The Obama administration was yesterday facing a crisis in its diplomatic service, amid growing evidence that the ongoing publication of a tranche of supposedly-confidential communiqu©s will make normal work difficult, if not dangerous, for important State Department employees across the world,” reporters Guy Adams and Kim Sengupta said, adding that the threats that additional cable could be published are “leading to fears that the unhelpful revelations will continue for months to come, destabilizing US relations with almost all of its key allies and inflaming tensions with already-hostile governments in the Middle East and beyond.”

“The Pentagon, the CIA and the State Department are reported to be identifying which members of staff have been named as the authors of the most unhelpful memos to have been published by Wikileaks,” added Adams and Sengupta. “They will need to be removed from what are among America’s most strategically-important postings.”

On the Sunday NBC television program Meet the Press, Republican Senator Mitch McConnell said that Assange was “a high-tech terrorist” and that he hoped the Wikileaks founder would be prosecuted for the “enormous damage” that publishing those confidential documents had done to the US, both domestically and internationally, according to Heilprin.

All the while, the spread of the documents has continued, despite attempts to shut down Wikileaks for good. In an interview with the AP, Pascal Gloor, Vice President of the Swiss Pirate Party–a group that is assisting Assange–said that their Wikileaks.ch website was receiving approximately 3,000 visitors each second, and that several mirrors of the Wikileaks site were being hosted on their servers.

“Even if you take down the server in Sweden, it’s too late,” Gloor told Heilprin on Sunday. “There are hundreds of mirrors of Wikileaks now”¦ It’s a test for Internet censorship. Can governments take something off the Net? I think not. There are copies of the website everywhere.”

While the documents may still be available, federal officials are being warned not to access them. In a memo obtained by Fox News, the Office of Management and Budget (OMB) warned its employees not to view any of the information distributed by the website, telling all employees and contractors that all of the documents must first be “declassified by an appropriate U.S. government authority” before they can be reviewed by personnel without proper security clearance.

Fox News also reported that the memo told officials that they are “obligated to protect classified information pursuant to all applicable laws, and to use government information technology systems in accordance with agency procedures so that the integrity of such systems is not compromised.” It does not, however, call for blockage of the Wikileaks website, as individuals with proper security clearance are permitted to access and review the classified documents.

Also on Sunday, new details came to light about one of the cables released by Wikileaks–a memo, sent from the US Embassy in Beijing to Washington D.C. accusing Chinese officials of orchestrating cyberattacks against Google in late 2009. According to Gillian Wong of the AP, the document said that a “well-placed” contact had told diplomats that the attacks were ordered by the Politburo Standing Committee, which Wong calls “the apex of Communist Party power.”

“The details of the memos, known in diplomatic parlance as cables, could not be verified,” the AP reported added. “Chinese government departments either refused to comment or could not be reached. If true, the cables show the political pressures that were facing Google when it decided to close its China-based search engine in March.”

On Friday, Senators John Ensign, Scott Brown, and Joseph Lieberman, introduced a bill that would make it illegal to publish the names of military and intelligence agency informants. The legislation, dubbed the Securing Human Intelligence and Enforcing Lawful Dissemination Act or SHIELD Act, would amend the existing US Espionage Act, is widely believed to be a direct response to Assange’s leaks.

“Our foreign representatives, allies, and intelligence sources must have the clear assurance that their lives will not be endangered by those with opposing agendas, whether they are Americans or not, and our government must make it clear that revealing the identities of these individuals will not be tolerated,” Lieberman, the chairman of the Senate Homeland Security Committee, said in a statement last week. “This legislation will help hold people criminally accountable who endanger these sources of information that are vital to protecting our national security interests.”

“The reckless behavior of Wikileaks has compromised our national security and threatened the safety of our troops overseas, and this bipartisan legislation gives the Department of Justice a tool to prevent something like this from happening again,” added Brown. “While I strongly support government transparency, certain information must be kept classified in order to protect innocent American lives during this time of war and global terrorism.”

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SpaceX Rocket Test Successful

Space Exploration Technologies (SpaceX), one of two companies primed to take over space ferry duties to the International Space Station (ISS) once NASA retires its space shuttle program, test-fired a rocket on Saturday in preparation for a Tuesday launch, according to officials.

After two aborted test-fire attempts earlier on Saturday and on Friday due to problems, the rocket’s nine liquid oxygen and kerosene-burning engines were briefly ignited at 10:50 a.m. EST Saturday, after the issues had been resolved, the company said in a statement on its website.

SpaceX plans to launch the Falcon Rocket on Tuesday at 9:03 a.m. EST from Cape Canaveral Air Force Station as a demonstration mission for NASA.

Officials said the goal of the flight is to put a Dragon capsule into space for a test run around Earth. After as many as four orbits, the capsule is expected to re-enter the planet’s atmosphere and parachute safely into the Pacific Ocean off the coast of California.

NASA awarded contracts to SpaceX and Orbital Sciences Corp., worth an estimated $3.5 billion, to deliver cargo to the space station after the shuttles are retired next year. NASA is helping to pay for both firms to develop and test their rockets and capsules.

SpaceX also has plans to upgrade the Dragon capsule for passenger space transport.

SpaceX’s contract with NASA calls for up to three demonstration missions before it begins cargo missions to the ISS, the first of which is slated for December 2011.

The second test mission will include the Dragon rendezvousing with the station, and the third test mission will dock. Depending on the Dragon’s performance during its maiden test flight, the second and third missions could be combined into one, pending NASA’s approval.

Orbital Sciences plans to debut its Taurus 4 launcher next summer.

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More Deaths From Pregnancy Complications In The US

Though pregnancy-related deaths in the United States remains relatively rare, the national rate of women dying due to pregnancy complications is growing, a government study has recently found.

Researchers from the US Centers for Disease Control and Prevention (CDC) found that between 1998 and 2005, pregnancy-related death rates were 14.5 per 100,000 live births. And even though that number is quite low, it is higher than at any time in the past few decades, according to a Reuters report.

The extent to which the rise reflects a true elevation in pregnancy-related risk of dying is unclear, the researchers cautioned. Recent changes in how causes of death are officially reported by states to the feds may be at least partially responsible for the findings.

It is possible that part of the increase is “real.” According to new data, deaths from chronic medical conditions that are often made worse by pregnancy, including heart disease, appear to account for a growing number of pregnancy-related deaths. But on the other hand, deaths from actual obstetric complications, such as hemorrhaging and pregnancy-related high blood pressure, are surprisingly declining.

The overall risk of American women dying from pregnancy-related issues is still “very small,” lead researcher Dr. Cynthia J. Berg, of the CDC’s division of reproductive health, told Reuters Health in an interview.

She said, however, that the new findings do emphasize the importance of women “making sure they are in the best possible health before pregnancy.”

All women should try to have a pre-pregnancy visit with their ob-gyn and, if needed, get their weight and any chronic medical conditions under control before becoming pregnant, Berg said.

Berg and her colleagues sifted through data on 4,693 pregnancy-related deaths reported to the CDC between 1998 and 2005. Pregnancy-related death was any death that occurred during or within one year or pregnancy and was accredited to a pregnancy complication.

The team estimated that the national rate of pregnancy-deaths was 14.5 per 100,000 live births for the eight-year study period. That is nearly double the numbers from 1986, when the pregnancy-related death rate fell to as low as 7.4 per 100,000 live births that year. Since then, there was a gradual increase in pregnancy-related deaths.

Berg said the reasons for the growing trend in overall pregnancy-related deaths are not certain, and more studies are needed to determine what contributing factors are involved.

The research team said one factor could be two technical changes in how cases of death are officially reported. The United States adopted an updated system for coding causes of death, which allowed for more deaths to be classified as “maternal.”

In 2003, the system was updated to include a “pregnancy checkbox,” which increased the number of deaths that could be linked, time wise, to pregnancy.

In recent years, not only has changes in the rate of pregnancy-related deaths occurred, but also in the specific causes.

Berg told Reuters Health that the proportion of deaths from obstetrical complications is going down, while the proportion attributed to indirect causes — medical conditions that worsened due to pregnancy — is increasing.

Hemorrhaging, one direct complication of pregnancy, accounted for nearly 30 percent of pregnancy-related deaths between 1987 and 1990, but only 12 percent between 1998 and 2005. High blood pressure disorders, mainly preeclampsia, also accounted for 12 percent of deaths between 1998 and 2005, down from 18 percent between 1987 and 1990.

In contrast, there was a sharp increase in the proportion of deaths accredited to heart problems. Between 1998 and 2005 about 12 percent of pregnancy-related deaths were attributed to cardiovascular complications, and another near-12 percent were attributed to enlargement of the heart.

Whereas only about 5 percent of deaths were associated to enlargement of the heart between 1987 and 1990, and even a smaller percentage for cardiovascular conditions.

While the study cannot separate the precise reasons for these patterns, Berg noted that “our population is changing.”

More women of childbearing age today are obese or have chronic health problems like high blood pressure and diabetes than women of years past. That could explain the shifting pattern in the causes of pregnancy-related deaths, Berg said.

Even though the numbers are still quite low for pregnancy-related deaths, Berg said it is important to go into pregnancy in the best possible health.

The CDC report was published in the recent issue of Obstetrics & Gynecology

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Urban Youth Cope With Neighborhood Violence In Diverse Ways

Some fight back, others withdraw, some strive to do better in school

Experiences with violence cause teens growing up in dangerous neighborhoods to adopt a range of coping strategies, with notable impact whether the violence takes place at home, among friends or during police incidents, a University of Chicago study shows.

The responses to violence include seeking out non-violent friends, avoiding trouble, becoming resigned to the situation, striving to do well in school, or for some, retaliating physically, the authors said.

“Exposure to community violence is pervasive among youth in many urban neighborhoods. We found in one study that 76 percent of urban youth were exposed to some kind of community violence during the previous year,” said Dexter Voisin, associate professor at the School of Social Service Administration and an expert on the impact of violence on youth people.

In a new study, Voisin explored how young people respond to the violence through a series of in-depth interviews with teens from a troubled area. The results were published in the article, “Everyday Victims: African American Adolescents Living and Coping with Exposure to Community Violence in an Inner-City Neighborhood,” published in the current issue of the Journal of Interpersonal Violence.

He and his research team recruited 32 Chicago-area boys and girls, ranging in age from 14 to 17, for the study. Most were not from low-income homes, and nearly 40 percent reported their mothers had some college education.

The youths were asked to describe their neighborhoods and their individual experiences with violence and their responses to it. The study found that boys were much more likely to witness and be victims of community violence than girls, who frequently heard about such violence. The girls were more likely than the boys to spend their non-school time at home, he said.

“The primary forms of violence exposures were physical attacks, fighting, incidents involving police, and gun violence involving murders,” Voisin said.

The teens told the research team about the violence they had witnessed or heard about from others. One teen described seeing a friend die in front of him, while the dying boy’s girlfriend stood nearby. The girlfriend was pregnant with his child, and as the boy lay dying, he said he regretted not being able to live to see his child.

The interviews also shed new light on understanding the relationship between police and teens, who often distrust the police.

“A noteworthy and unique finding, which has not been commonly discussed in prior research, is exposure to police incidents as a form of community violence exposure,” Voisin writes. The boys reported being stopped and questioned by police, seeing police chasing and shooting community residents, and police coming into their homes to arrest family members.

Teens most often coped by associating with people in their neighborhood who are not part of the violence, Voisin said. “A second strategy was to avoid situations where violence might erupt, often by isolating themselves,” he added.

Other approaches included either becoming resigned to their situation or in some cases learning to fight back or carry a gun.

For nearly a quarter of the students, however, achievement in school was their ticket to a better future. Those youth told the research team that doing well in school could mean they would be able to get a good job and move to a safer neighborhood.

In order to deal with the violence the students experience, Voisin recommends that schools provide more counseling opportunities to reduce youth’s symptoms of distress associated with violence and work with the community to reduce gang activity and the availability of guns.

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Mylanta Latest J&J Product Facing Recall

The US Food and Drug Administration (FDA) has announced a recall of Mylanta and AlternaGel liquid antacids, making it the latest in a long line of Johnson & Johnson affiliated products to face a recall this year.

The products, which are manufactured by Johnson & Johnson-Merck Consumer Pharmaceuticals, Co. (JJMCP), are being recalled due to a labeling issue. Each of the 12 varieties of Mylanta and the one version of AlternaGel affected by the notice contain a trace amount of alcohol that was not revealed on the product labels, the company said in a statement.

“It is unlikely that use of these products will cause either alcohol absorption or alcohol sensitivity related adverse events,” J&J’s recall notice reports. “This is a wholesale and retail level recall and is not being undertaken on the basis of adverse events. No action is required by consumers or healthcare providers and consumers can continue to use the product.”

The specific varieties of each antacid being recalled are Mylanta Regular Strength Original, 12 ounce size; Mylanta Original, 5 ounce size; Mylanta Regular Strength Mint, 12 ounce size; Mylanta Maximum Strength Cherry, 12 ounce size; Mylanta Maximum Strength Mint, 12 ounce size; Mylanta Maximum Strength Original, 12 and 24 ounce sizes; Mylanta Ultimate Strength Mint, 12 ounce size; Mylanta Ultimate Strength Cherry, 12 ounce size; Mylanta Supreme Tasting with Calcium Cherry, 12 and 24 ounce sizes; and AlternaGel, 12 ounce size. Product codes are available on the FDA’s website.

Previously, on November 24, the company announced a recall of 9.3 million bottles of Tylenol-brand cold treatment, also for labels that failed to disclose the medicine’s alcohol content. Also last month, J&J pulled 4 million packages of Children’s Benadryl allergy tablets and 800,000 bottles of Junior Strength Motrin pain reliever/fever reducer caplets due to “insufficiencies in the development of the manufacturing process.”

According to Ransdell Pierson of Reuters, “All told, more than 200 million bottles of J&J products have been recalled in the past year”¦ The crisis has harmed J&J’s once-pristine image and is beginning to take a significant toll on its financial results. U.S. sales”¦ plunged 25 percent in the third quarter as scores of formulations became unavailable and customers opted instead for generic store brands.”

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Treating Hamstring Injuries with Blood

(Ivanhoe Newswire) ““ Researchers in London believe they have found an effective two-part treatment for microtears in the hamstring: injections of the patient’s own blood and steroid along with “dry-needling,” where repeated needle punctures cause controlled internal bleeding in the injured area.

“By injecting the patient’s own blood where it is needed at the site of a damaged tendon, we help the patient heal themselves,” lead researcher Waseem A. Bashir, M.D., a radiologist at Royal National Orthopaedic Hospital and Ealing Hospital in London was quoted as saying. “Blood contains many growth factors, and the injections have been shown to promote faster healing of certain injuries.”

Hamstring tendinopathy is a common sports injury that occurs in any sport that requires quick acceleration. It may be caused by an incorrect warm-up or, the result of repetitive strain. Different from a torn or ruptured tendon that can be surgically repaired, the tiny microtears that characterize chronic tendinopathy are not easily diagnosed, are difficult to heal and often sideline athletes for long periods, if not permanently.

“Patients with hamstring tendinopathy will experience pain walking or climbing stairs and even while sitting or riding in a car,” Dr. Bashir said. “The condition is literally a pain in the butt.”

In the study, 42 patients with suspected hamstring microtearing had an ultrasound and a MRI to confirm the tendinopathy, and then were randomly assigned to one of three treatment groups. The first group received an injection of both a long-lasting anesthetic and steroid on the surface of the tendon, as well as the dry-needling procedure at the site of microtears.

The second group received an injection of the anesthetic along with two to three milliliters of their own blood, called an autologous blood injection (ABI), and dry-needling. The third group received a local anesthetic, a steroid and ABI along with dry-needling.

“The injections were all performed with ultrasound and color Doppler, which allows us to watch in real-time where the needle is going,” Dr. Bashir said. “During the dry-needling, we can see blood flow increase in the area.”

After the treatments, all patients in the study participated in a structured six-week physiotherapy program. The patients were then evaluated at different times over a one-year period to assess their levels of pain and functioning.

Patients from the first group reported improved functionality for only three to 12 weeks after treatment. A year later, patients in this group reported being at pre-treatment levels of pain and functionality. Patients who received their own blood plus dry-needling reported significant improvements in functionality even one year after the treatment. Patients from the third group experienced the most significant reduction in pain levels and the most sustained functional improvement one year following treatment.

“Ultrasound-guided ABI in the hamstring, in combination with a local steroid and dry-needling, appears to be a more clinically effective alternative to the current standard, steroid therapy,” Dr. Bashir said. “A few of our soccer-playing patients had been told their condition was untreatable and they had basically given up all hope of playing again. They were amazed to be able to play again after our treatment and physical therapy.”

He added that ABI therapy has also been an effective treatment for microtears in other tendons, including the elbow, the patellar tendon and those in the rotator cuff within the shoulder.

SOURCE: The annual meeting of the Radiological Society of North America (RSNA) held in McCormick Place, Chicago from November 28- December 3, 2010

Amazon Halts Wikileaks Hosting

After criticism from congressional staff, Amazon decided to boot Wikileaks from its servers, forcing the whistleblower website to use Web-hosting services in Europe, Wikileaks said Wednesday.

According to the Associated Press (AP),  Senator Joe Lieberman said Amazon was questioned about its relationship with Wikileaks, which led to the online retail company cutting its ties with the whistleblower website.

Wikileaks confirmed the ousting hours after AP reported that Amazon’s servers had stopped hosting the Wikileaks site. The site was unavailable for several hours before being moved back to Bahnhof AB, its previous host in Sweden.

Wikileaks had released a host of sensitive diplomatic documents on Sunday. Just before the release, the website suffered an Internet-based attack that made it unavailable for hours at a time. Wikileaks reacted by moving the site from Swedish servers to Amazon Web Services that can be rented on a self-service basis to meet traffic surges.

But that move came with much legal and political pressure from US authorities.

“Wikileaks servers at Amazon ousted. Free speech the land of the free–fine our $ are now spent to employ people in Europe,” the whistleblower said Wednesday in a Twitter post.

“If Amazon are so uncomfortable with the first amendment, they should get out of the business of selling books,” Wikileaks said in another tweet.

“The company’s decision to cut off Wikileaks now is the right decision and should set the standard for other companies Wikileaks is using to distribute its illegally seized material,” Lieberman said in a statement to AP. He said he planned on questioning Amazon further about the affair.

Wikileaks has no solid geographic home, but founder Julian Assange sought to establish residency in Sweden to take advantage of laws protecting those who funnel info out to the media. However, Swedish authorities denied his application for a residency permit.

There is now an international arrest warrant out for Assange based on allegations of sexual assault rooting from his stay in the country. Assange has denied the charges. The Swedish police have yet to file formal charges however. The Wikileaks founder’s whereabouts are unknown.

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Johnson & Johnson Recalls Contact Lenses

Johnson & Johnson confirmed Wednesday that it had recalled nearly half a million boxes of contact lenses, five times more than the actual number it had announced in August due to eyes stinging.

The recall consists of Johnson & Johnson’s 1 Day Acuvue TruEye lenses. The company originally said 100,000 boxes would be recalled back in August, but was expanded to a total of 492,000 boxes, and included mainly products in Japan.

The New Jersey-based healthcare giant, which has been striving for greater transparency in the wake of a series of over-the-counter medicine recalls, said it announced the expanded recall by press release only in Japan, where nearly 75 percent of the affected product was sold.

J&J is already facing criminal and congressional scrutiny in the United States over the series of massive recalls of Children’s Tylenol, Motrin, Benadryl, and others due to lapses in quality control and other issues.

The recall on contact lenses does not affect products sold in the United States.

The expanded product recall was made public Wednesday after details of the recall were posted on a UK healthcare regulatory agency website. Healthcare officials in all countries with affected lots were notified of the expanded recall in late October, Gregory Esterow, a spokesman for J&J’s Vistakon vision care unit, told Reuters.

Some 25 European Union countries were involved in the limited voluntary recall, including the UK, Sweden, Italy, Ireland and Germany. Acuvue lenses were also recalled in Canada, Australia, South Korea, Hong Kong, Malaysia, New Zealand and Singapore, the company said.

J&J told Reuters that the affected lot of contact lens recalls represents less than 1 percent of all contact lenses made by the company worldwide.

The voluntary recalls came after consumer complaints of burning, stinging or pain upon inserting the lenses into the eyes surfaced.

A product review revealed higher-than-expected levels of a type of acid used in manufacturing the lenses that had not been fully removed during the lens rinsing process. Esterow said the company also found a small percentage of lenses that did not meet internal manufacturing requirements.

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Researchers Discover How Worms Promote Healing

Findings identify potential strategies for treating inflammatory bowel diseases

A new study involving a man who swallowed worm eggs to relieve symptoms of ulcerative colitis sheds light on how worms promote healing in the intestine. The study, published today in Science Translational Medicine, also identifies potential targets for more conventional ways of treating colitis, an inflammatory bowel disease.

“The idea for treating colitis with worms is not new, but how this therapy might work remains unclear,” says the study’s senior corresponding author, P’ng Loke, PhD, assistant professor of medical parasitology at NYU Langone Medical Center. “Our findings suggest that infection with this particular parasite increases or restores mucus production in the colon, providing symptomatic relief.”

A chronic disease, ulcerative colitis is characterized by open sores or ulcers in the lining of the colon. The disease is estimated to affect 600,000 Americans, according to the Crohn’s & Colitis Foundation of America, and the most common symptoms are abdominal pain and bloody diarrhea. The cause is unknown, but studies points to defects in immune regulation. Disruption of mucus production is often associated with severe symptoms.

Colitis is common in North America and Northern Europe, where helminth (parasitic worm) infections are rare. Conversely, the disease is rare in Asia, Africa, and Latin America, where helminth infections are endemic, leading researchers to hypothesize that the worms offer protection against this inflammatory bowel disease. In animal models of autoimmunity these worms have suppressed inflammation, and clinical trials indicate that helminth therapy can be beneficial in relieving symptoms of inflammatory bowel diseases.

To gain a better understanding of how such therapy works, Dr. Loke and his colleagues analyzed a series of blood and tissue samples taken from a 34-year-old man living in California with ulcerative colitis who ingested Trichuris trichiura eggs (a roundworm that infects the lower intestine) after having researched the scientific literature. After several months, his condition improved dramatically and he remained in remission for almost three years. A subsequent cycle of self-treatment with the worm eggs achieved similar results.

Tissues samples taken when the patient had active disease were found to contain high numbers of a type of immune cell (CD4+ T cells) that produces an inflammatory protein called interleukin-17. Tissue samples taken after exposure to the worms, when the disease was in remission, contained an abundance of T cells that produce interleukin-22 (IL-22), a protein important in mucosal healing. To expel the worm, the researchers note, the immune system appears to activate specialized cells that increase mucous production in the entire colon.

“In essence, the worms trigger a big sneeze of the gut, which may have a beneficial side effect for ulcerative colitis,” says Dr. Loke, who does not advocate helminth therapy. “The problem is that these worms themselves can cause harm and damage the gut. The individual in this study is lucky to have responded so well, but for other people the worm infection may exacerbate bowel inflammation,” he says.

It is impossible right now to predict who might be helped and who might be harmed by infection with these worms. Studies are underway, adds Dr. Loke, using a worm that infects pigs (T. suis) to treat colitis, which should be less risky.

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SOHO Celebrates 15 Years

On December 2, 1995, the Solar and Heliospheric Observatory or SOHO was launched into space from Cape Canaveral aboard an Atlas IIAS rocket. The joint ESA/NASA project began its work observing the sun at a time when the term “solar weather” was almost never used.

Fifteen years later, SOHO has revolutionized what we know about the solar atmosphere and violent solar storms produced by the sun. SOHO has become an expert comet-hunter, nightly news leader and a workhorse that helped create the field of near-real-time space weather reporting as we know it ““- but it started as a tool to answer three scientific questions about the sun.

“We were looking for answers to three long-standing problems in solar physics,” said Joe Gurman, “the solar neutrino problem, the coronal heating mystery, and the question of what causes solar wind acceleration.” Gurman works at NASA’s Goddard Space Flight Center in Greenbelt, Md., and has been the U.S. project scientist for SOHO since 1998.

Placed into orbit around the L1 Lagrangian point between Earth and the sun, SOHO was able to observe the sun continuously without Earth ever obstructing its view. With its uninterrupted observations, says Gurman, SOHO has significantly helped with all three original questions.

First, the so-called solar neutrino problem was a conflict between how many neutrinos were predicted by fusion and models of the solar interior versus how many were in fact detected. SOHO confirmed that the interior models were correct and helped show that, instead, the detectors were not finding all the neutrinos since they were changing after they left the sun. Second is the coronal heating mystery, so called because the Sun’s outermost atmosphere, or corona, is unexpectedly hundreds of times hotter than the sun’s surface. SOHO helped determine that the movement of the Sun’s small-scale magnetic fields themselves could contribute, in principle, sufficient energy to heat the corona. Third, SOHO observed that the acceleration of the solar wind appears to be powered by a special kind of waves that can accelerate certain particles preferentially.

SOHO is perhaps best known for its observations of coronal mass ejections, or CMEs. These blasts of gas and magnetic fields are a fundamental concern for those who track and attempt to forecast space weather. But when SOHO launched in 1995, there was disagreement over what a CME headed for earth looked like. The first ever videos of a CME wave in the lower corona in April of 1997, combined with SOHO’s white light coronagraph observations of the accompanying “halo” CME, changed all that.

Steele Hill, who leads public outreach for SOHO at Goddard, had then only been working for the SOHO team for six months. “It was the first time we had witnessed an event like that. We could track it, predict its direction, and say that in two to three days it will have some impact on Earth.” Hill pulled together some SOHO files and made a movie. . . and it was the first story on the national news that night in April 1997.

An unexpected destiny for SOHO is that it has become the greatest comet-finder of all time. With its data stream available publicly, anyone can be a comet hunter — and as of November 1, 2010, SOHO had spotted more than 1,940 of them. (A contest to predict the day on which the 2,000th will be spotted is here.)   

After a good 15-years, SOHO isn’t easing in to retirement yet. A long archive of data such as SOHO’s is necessary to spot some of the tiniest waves that propagate through the body of the sun. Known as buoyancy or gravity-mode waves, these waves only disturb the surface of the sun at a speed of a millimeter per second.

“That’s a pretty hard measurement to do,” says Gurman. “With 15 years of observations, we just might have a strong enough signal.”

In addition, SOHO is still our only solar observatory to have gathered images of the sun during a solar maximum. The last maximum was in 2000. As we move into the next peak in 2013, it will be SOHO’s legacy that allows scientists to compare and contrast what we see now in newer missions such as the Solar Dynamics Observatory (SDO) and the Solar TErrestrial RElations Observatory (STEREO) to what was seen then.

“Every mission stands on the shoulders of the missions that came before it,” says Gurman. “Without the success of SOHO we never would have had the opportunity to get even better measurements with STEREO, Hinode, and SDO.”

Karen C. Fox, NASA’s Goddard Space Flight Center

Image 1: Artist’s Concept of SOHO spacecraft observing the sun. Credit: NASA/A. Lutkus/H. Zell

Image 2: SOHO launching on the Atlas II-AS (AC-121) at Cape Canaveral Air Station on December 2, 1995. Credit: NASA

Image 3: This coronal mass ejection — observed by SOHO’s EIT 195 instrument on April 7, 1997 — was the first visual image of such an ejection headed for Earth. It appeared as the lead story on the national news. Credit: SOHO/ESA/NASA

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Anti-Whaling Activists Unveil New High-Speed Interceptor

The Sea Shepherd Conservation Society, a group of Australian anti-whaling activists, has announced the christening of a new, $4 million, high-speed vessel that they claim is the fastest and strongest interceptor in the organization’s history.

The craft, dubbed Gojira (the Japanese name of famous movie monster Godzilla), was christened earlier this week during a ceremony held at the Fremantle fishing boat harbor in Western Australia, according to a press release posted Monday to the organization’s official website.

According to that press release, the 100-foot monohull vehicle was already en route to Tasmania, where it would join the rest of the Sea Shepherd’s fleet to battle whalers in the Southern Ocean Whale Sanctuary. It will replace the Ady Gil, which was lost in January following a conflict.

“This vessel can outrun any Japanese vessel which means that we will have the element of surprise,” Jeff Hansen, Director of the Sea Shepherd Conservation Society, told the Daily Mail on Wednesday. “We can find the factory ship and the factory ship is the one we’re after. If we can find the factory ship we can shut down whaling.”

The goal, Hansen told the Daily Mail, it to prevent their foes from reaching their 1,000 whale quota in the Southern Ocean sanctuary. Gojira is the first Australian-registered vessel in the group’s 33-year history, and according to a statement released by Hansen on their website, it will solidify the continent’s position as “the most passionate defender of whales in the world.”

Just how fast is the ship? Hansen isn’t saying.

“We are not going to release the speed (it can reach), we are just saying that it is going to go faster than a harpoon ship,” he told the AFP on Wednesday, though he did note that he believed it would help the group reach their destination before the whalers for the very first time.

“This vessel is purely to be used for its speed advantage,” Hansen added. “We’re in a very, very good position right now. We’re the best prepared we’ve ever been.”

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Breast Cancer Survivor? Consider Yearly MRI and Mammography

(Ivanhoe Newswire)– Whether a mother, daughter, sister or aunt, your role as a woman often leads you caring more about others than yourself.  It’s time to take your health personal and if you’ve had a bout with breast cancer before, considering a yearly breast MRI in addition to mammography is far from a bad idea.

The American Cancer Society (ACS) guidelines currently recommend annual screening with breast MRI in women with a known gene mutation or with a strong family history indicating a lifetime risk of breast cancer greater than 20 percent. However, the guidelines say there is insufficient evidence to recommend for or against MRI screening in women who have already had breast cancer themselves.

“In our study using breast MRI screening, we actually detected proportionally more cancers in women with a personal history of breast cancer, compared with those women with a genetic mutation or strong family history who are currently recommended to have breast MRI,” Wendy B. DeMartini, M.D., assistant professor in the Department of Radiology at the University of Washington Medical Center and Seattle Cancer Care Alliance in Seattle, was quoted as saying. “Further, women with a personal history were less likely to be recalled for additional testing and less likely to have a biopsy for a false positive MRI finding.”

Dr. DeMartini and colleagues performed a retrospective review of initial screening breast MRI examinations of 1,026 women from January 2004 to June 2009. Of the 1,026 women, 327 had a genetic or family history of breast cancer and 646 had a personal history of treated breast cancer.

Overall, MRI testing identified 25 of 27 cancers in the group for a sensitivity rate of 92.6 percent.

The cancer yield in the women with a personal history of breast cancer (3.1 percent) was double that of the women with a genetic or family history (1.5 percent). Specificity in women with a personal history was 93.6 percent, compared with 86.3 percent for the other group. Specificity refers to the accuracy of the exam in correctly ruling out cancer where it is not present, resulting in lower recall and biopsy rates due to false-positive findings.

Biopsy was recommended in 9.3 percent of the women with a personal history of breast cancer, compared with 15 percent of the genetic and family history group. The positive predictive value of biopsy was also higher in the personal history group, with 35.7 percent of biopsies yielding cancer, compared with only 12.2 percent in the other group.

“Our findings show that the diagnostic performance of MRI in patients with a personal history of treated breast cancer supports consideration of screening MRI as an adjunct to mammography,” Dr. DeMartini said. “Additional studies such as ours are necessary to establish guidelines for screening this important group of women.”

SOURCE: Radiological Society of North America, December 2010

More Americans Should Get HIV/AIDS Test

Guidelines set to make AIDS testing a part of routine healthcare checkups have helped get more Americans tested for the disease that claims the lives of more than 2 million people annually worldwide, but more than half of US adults still have no idea if they are infected or not, government researchers reported Tuesday.

Nearly 83 million Americans have been tested for AIDS, 11.4 million since the guidelines were established in 2006, according to the US Centers for Disease Control and Prevention (CDC).

But CDC director Dr. Thomas Frieden said as many as 200,000 Americans are infected with the virus and do not know it. “The numbers show that progress is possible,” he told a news conference.

But the numbers also show that “progress is needed,” he added. “To see a steady improvement in just a two or three year period, I think, is quite encouraging. It’s progress but it’s not success.”

The CDC estimates that 1.1 million Americans are infected with human immunodeficiency virus that causes AIDS, with 56,000 new infections every year.

The CDC’s Dr. Jonathan Mermin told Reuters that people who do not know they are infected are far more likely to infect someone else with the incurable virus. 

“People who know they are positive cut their risky behaviors in half,” Frieden said.

While there is no known cure for HIV and AIDS, a host of drugs can keep people healthy and studies also show that HIV patients who take the drugs are less likely to transmit the virus, which is spread through blood, semen, breast milk and by use of contaminated needles.

In 2006, instead of having people ask for HIV tests, the CDC said people should be automatically tested for the disease unless they opt out. “It should be a normal, routine part of care,” said Frieden.

“Today’s data shows that following those recommendations, there was a significant increase in the number of Americans who were tested for the first time,” he added.

Last year, an estimated 45 percent of Americans between ages 18 and 64 reported that they had an HIV test at least once in their lives, up from 40 percent in 2006. That equals an increase of 11 million people who have ever been screened, the CDC reported.

“Despite this progress, 55 percent of adults, and 28.3 percent of adults with a risk factor for HIV, have not been tested,” the CDC noted.

And 32 percent of people diagnosed with HIV in 2007 progressed to AIDS within 12 months. “In other words, they had unknowingly been infected with HIV for years without being diagnosed,” Mermin said.

On average, it takes 10 years for a person infected with HIV to develop AIDS if he or she is not treated.

Because more people are getting tested, fewer people are being diagnosed late with HIV, said Frieden. In 2007, about a third of infections were discovered late, an improvement from 37 percent diagnosed earlier in the decade. Frieden said those cases are often only detected when the disease has progressed to AIDS.

Dr. John Bartlett of Johns Hopkins University called the testing figures disappointing. “It’s an incremental gain,” Bartlett, an infectious disease specialist, told The Associated Press.

He said that when the CDC changed the guidelines, many states still had laws that required special counseling before and after HIV tests. Most states have since dropped the restrictions, but there are still some obstructions. Maryland, for example, still requires doctors to note the patient’s consent on charts.

More screening could be done if hospitals were pressured to adopt routine testing of patients by Medicare or hospital groups, said Bartlett.

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The Couch Potato Effect

Deletion of key muscle protein inhibits exercise

Daniel Kelly, M.D., and his colleagues at Sanford-Burnham Medical Research Institute (Sanford-Burnham) at Lake Nona have unveiled a surprising new model for studying muscle function: the couch potato mouse. While these mice maintain normal activity and body weight, they do not have the energy to exercise. In the December 1 issue of Cell Metabolism, Dr. Kelly’s team reports what happens when muscle tissue lacks PGC-1, a protein coactivator that muscles need to convert fuel into energy.

“Part of our interest in understanding the factors that allow muscles to exercise is the knowledge that whatever this machinery is, it becomes inactive in obesity, aging, diabetes and other chronic conditions that affect mobility,” Dr. Kelly explained.

Normally, physical stimulation boosts PGC-1 activity in muscle cells, which switches on genes that increase fuel storage, ultimately leading to “trained” muscle (the physical condition most people hope to attain through exercise). In obese individuals, PGC-1 levels drop, possibly further reducing a person’s capacity to exercise ““ creating a vicious cycle. In this study, mice without muscle PGC-1 looked normal and walked around without difficulty, but could not run on a treadmill.

This is the first time that PGC-1 has been completely removed from muscle tissue, providing researchers with a new model to unravel the protein’s role in muscle development, exercise and metabolism. So what happens to mice with muscles short on PGC-1? Their mitochondria ““ the part of the cell that converts fuel into energy ““ can’t function properly, so cells have to work harder to stay vigorous. This extra effort rapidly depletes carbohydrate fuel stores, leading to premature fatigue. In short, PGC-1 is necessary for exercise, but not normal muscle development and activity.

But these mice held another surprise. PGC-1-deficient couch potato mice were not obese and still respond normally to insulin ““ meaning they are not at risk for developing diabetes despite their sedentary lifestyles and mitochondrial problems. This was unexpected because many scientists believe that dysfunctional mitochondria trigger a cascade of insulin resistance and diabetes. This study dispels that notion, instead suggesting that perhaps malfunctioning mitochondria are a result of diabetes, rather than a cause.

“Lo and behold, even though these animals couldn’t run, they showed no evidence of insulin resistance,” Dr. Kelly said. “We are now investigating what happens when we boost PGC-1 activity intermittently, as normally occurs when a person exercises.”

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Volunteers Needed For HIV Vaccine Trial

Baylor College of Medicine is recruiting volunteers for a nationwide vaccine trial testing the safety and efficacy of a combination of two potential HIV vaccines and to see if they will stimulate an immune response to HIV.

“The HIV epidemic is still out of control. While HIV medications have improved the survival of people infected with HIV, developing methods to prevent or modify disease are badly needed to change the outlook of this epidemic,” said Dr. Hana El Sahly, assistant professor of molecular virology and microbiology at BCM and principal investigator of the study.

The study is being conducted by the HIV Vaccine Trials Network and Baylor is one of 15 sites across the country participating in the trials. Neither of the vaccines can cause HIV infection.

Researchers are seeking HIV-uninfected (negative) men between 18 and 50 years of age who have sex with men or transgender women who have sex with men.

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Caffeinated Alcoholic Beverages Are A Growing Public Health Problem

Study in American Journal of Preventive Medicine explains consequences

In the wake of multiple state bans on caffeinated alcoholic beverages (CABs) and an FDA warning to four companies to remove their products from the marketplace, an article published online Nov. 29 in the American Journal of Preventive Medicine delineates the scope of the public health problem and suggests areas of research that might help address it.

“Although several manufacturers of caffeinated beer have withdrawn their products from the market, there is no sign that young people have decreased the practice of combining alcohol and energy drinks,” commented lead author Jonathan Howland, PhD, Department of Community Health Sciences and Department of Emergency Medicine, Boston University. “Critically, CABs may increase alcohol-related risks in a number of different domains, but have been subject to very little systematic research.”

The article provides 44 references gathered from newspapers, magazines, and the scientific literature showing the current understanding of the effects of stimulants combined with alcohol. One study found that bar patrons who consumed CABs had a three-fold risk of leaving the bar highly intoxicated, compared to those who consumed alcohol without caffeine, and a fourfold risk of intending to drive after leaving the bar. Another compelling study concluded that students who consumed CABs had approximately double the risk of experiencing or committing sexual assault, riding with an intoxicated driver, having an alcohol-related accident, or requiring medical treatment.

The root of the problem may have started with so-called energy drinks. Depending on the brand, these beverages contain several stimulants, primarily caffeine, but also guarana, taurine, and sugar derivatives. Of the 577 caffeinated beverages listed on the Energy Fiend website in 2008, at least 130 contained more than the 0.02% caffeine limit for soft drinks imposed by the U.S. Food and Drug Administration (FDA).

Combining these energy drinks with alcohol became popular when marketers promoted the perception that energy drinks counteract the sedating effects of alcohol and related impairment and suggested that caffeine will increase enjoyment by allowing one to party for a longer time. According to a 2006 survey, 24% of college students reported mixing energy drinks with alcohol in the past month.

The FDA issued warning letters on November 17, 2010 to the following companies, indicating that further actions, including seizure of their products, is possible under federal law.

    * Charge Beverages Corp.: Core High Gravity HG Green, Core High Gravity HG Orange, and Lemon Lime Core Spiked
      (http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/ucm233990.htm)
    * New Century Brewing Co., LLC: Moonshot
      (http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/ucm234028.htm)
    * Phusion Projects, LLC (doing business as Drink Four Brewing Co.): Four Loko
      (http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/ucm234023.htm)
    * United Brands Company Inc.: Joose and Max
      (http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/ucm234002.htm)

States with previously announced bans are New York, Washington, Iowa, Kansas, Massachusetts, Oregon, and Michigan. The FDA announcement will likely pre-empt further state bans.

The article is “Caffeinated Alcoholic Beverages: An Emerging Public Health Problem” by Jonathan Howland, PhD, Damaris J. Rohsenow, PhD, Tamara Vehige Calise, DrPH, James MacKillop, PhD, and Jane Metrik, PhD. It has been published online in advance of publication in the American Journal of Preventive Medicine, Volume 40, Issue 2 (February 2011) published by Elsevier. doi: 10.1016/j.amepre.2010.10.026

Image Courtesy Wikipedia

Taking Vitamin D, Calcium Supplements Not Necessary

Most people get enough vitamin D from the sun, and there’s no evidence that taking supplements of the so-called sunshine vitamin will fight off cancer, prevent diabetes, or strengthen a person’s immune system, a panel of U.S. and Canadian doctors said on Tuesday.

The announcement comes as part of a new set of dietary intake guidelines for both calcium and vitamin D, released this week by the Institute of Medicine (IOM), an independent American health agency established in 1863.

Using expert testimony and nearly 1,000 published studies analyzing the two nutrients, the IOM discerned that most North Americans 70 years of age or under need just 600 international units (IUs) of vitamin D per day, and those over the age of 71 need 800 IUs. Calcium intake, on the other hand, can vary from 700 to 1,300 milligrams daily.

“The committee that wrote the report also reviewed hundreds of studies and reports on other possible health effects of vitamin D, such as protection against cancer, heart disease, autoimmune diseases, and diabetes,” the IOM said in a Tuesday press release. “While these studies point to possibilities that warrant further investigation, they have yielded conflicting and mixed results and do not offer the evidence needed to confirm that vitamin D has these effects.”

However, both calcium and vitamin D were proven to have positive effects when it comes to bone health and skeletal growth and maintenance, the researchers noted.

“There is abundant science to confidently state how much vitamin D and calcium people need,” Committee Chairperson Catharine Ross, a professor with the Pennsylvania State University Department of Nutritional Sciences, said in a statement. “We scrutinized the evidence, looking for indications of beneficial effects at all levels of intake.  Amounts higher than those specified in this report are not necessary to maintain bone health.”

Children between the ages of 1 and 3 should consume 700mg of calcium per day, while kids between the ages of 4 and 8 should up their intake to 1,000mg, the IOM said. Individuals between the ages of 9 and 18 need no more than 1,300mg of calcium daily, while most adults between the ages of 19 and 50 can reduce their calcium intake back down to 1,000mg. Men over the age of 50 and under the age of 71 can maintain that level, while women are advised to up their consumption to 1,200mg daily.

“The majority of Americans and Canadians are getting enough vitamin D and calcium, the committee determined from reviewing national surveys of blood levels,” the IOM reported. “Some adolescent girls may not get quite enough calcium, and there is a greater chance that elderly individuals may fall short of the necessary amounts of calcium and vitamin D.  These individuals should increase their intake of foods containing these nutrients and possibly take a supplement.”

Overdosing on either nutrient can be dangerous, the researchers reported. Consuming high levels of vitamin D (at least 10,000 IUs daily) are known to cause kidney and tissue damage, they claim, and even taking 4,000 IUs daily could be risky. In terms of calcium, the IOM says that taking more than 2,000mg each day could lead to kidney stones, especially in post-menopausal women.

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Critical Habitat Set Aside For Alaskan Polar Bears

The Obama administration is setting aside more than 187,000 square miles (120 million acres) along the northern coast of Alaska designating it as a “critical habitat” for polar bears as a result of a partial settlement in an ongoing lawsuit brought by the Center for Biological Diversity, the Natural Resources Defense Council, and Greenpeace against the Department of Interior.

The total, which includes large areas of sea ice off the Alaskan coast, is about 13,000 square miles less than in a preliminary plan released last year.

Tom Strickland, Interior secretary for fish, wildlife and parks, said the designated area would help polar bears stave off extinction, recognizing that the greatest threat is the melting sea ice caused by ever-worsening climate change.

“This critical habitat designation enables us to work with federal partners to ensure their actions within its boundaries do not harm polar bear populations,” Strickland told AFP. “We will continue to work toward comprehensive strategies for the long-term survival of this iconic species.”

The designation does not in itself block economic activity or other development, but does require federal officials to consider whether a proposed action would adversely affect the polar bear’s habitat and interfere with its recovery.

Nearly 95 percent of the designated area is sea ice in the Beaufort and Chukchi seas off the northern coast of Alaska, where polar bears spend most of their time hunting for food, breeding and traveling.

Alaska’s Governor Sean Parnell, along with the state’s oil and gas industry, complained that the plan released last year was too large and dramatically underestimated the potential economic impact. The designation could lead to hundreds of millions of dollars in lost economic revenue, they said.

The US Fish and Wildlife Service said the reductions in designated habitat were mostly due to corrections that more accurately reflect the US border in the Arctic Ocean.

The Interior Department has declared that polar bears are threatened and likely to become endangered, largely in part to a dramatic loss of sea ice that is important to the survival of polar bears. Officials face a December 23 deadline to explain why the bears are listed as threatened instead of a more protective “endangered” status.

Kassie Siegel, a lawyer for the Center for Biological Diversity, one of the environmental groups that filed the lawsuit to increase protections for the polar bear, hailed the designation of critical habitat.

“Now we need the Obama administration to actually make it mean something so we can write the bear’s recovery plan — not its obituary,” Siegel told The Associated Press.

Siegel called for the administration to impose a ban on oil and gas drilling in polar bear habitat areas. “An oil spill there would be a catastrophe,” she said.

The US government is considering opening the Chukchi Sea to drilling but is reviewing leases awarded in 2008 after a lawsuit was filed by indigenous people and environmental groups that contended that the government does not have enough knowledge about how drilling would impact the environment.

Oil companies such as Royal Dutch Shell want to begin drilling in the upcoming months, once winter ice begins to break up, and are submitting plans to show they can meet tougher government rules and regulations.

The US Geological Survey said in 2008 that within the Arctic circle there are 90 billion barrels of oil and vast quantities of natural gas waiting to be tapped, most of it offshore.

The Interior Department listed the polar bear as a threatened species under the Endangered Species Act in May 2008, and issued a special rule exempting greenhouse gas emissions from being regulated as a result of the listing. The Center for Biological Diversity, NRDC and Greenpeace continue to challenge the regulation in court.

“Designating polar bear critical habitat is a good first step toward protecting this species,” said Melanie Duchin, a Greenpeace campaigner in Alaska. “However, as long as the secretary of the interior maintains that he can do nothing about greenhouse emissions and global warming, protections for the polar bear will ultimately be ineffective.”

Scientists have made it clear that polar bears need help soon. Global warming is continuing to reduce the sea ice that polar bears depend on to hunt, mate and raise cubs. If current greenhouse gas trends continue, scientists predict more than 30 percent of the world’s polar bears — including all the polar bears in Alaska — will probably be gone in as little as 40 years.

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IVF Donor Eggs May Lead To Preeclampsia

A new study suggests that women who use donated eggs to get pregnant by in vitro fertilization (IVF) might be more at risk for a potentially dangerous complication than women who use traditional IVF methods.

Women who use IVF — in which an egg is fertilized outside the body, then implanted into a woman’s uterus — are already believed to be at an increased risk for preeclampsia — a condition that occurs when a woman’s blood pressure rises during her second or third trimester and her kidneys fail to continue to retain protein.

Now, the study suggests that using donated eggs could possibly increase that risk even further. But doctors say more research is needed to confirm the findings.

Dr. Peter Klatsky, the lead author of the paper from Women and Infants Hospital in Providence, Rhode Island, said results from the study “should not be alarming or frightening.” Rather, the findings could help doctors understand what causes the condition and how to counsel patients who are at risk.

Preeclampsia is not a well-described condition, although being relatively common. About one in 20 pregnant women develop the condition, and the only cure is to give birth.

For those women who carry a baby to full term — at least 37 weeks — doctors can induce labor. In those who are in the earlier stages of pregnancy, doctors can only closely monitor the symptoms to make sure they do not progress.

Studies in the past have shown that women who use donor sperm and those who get pregnant with a new sexual partner have higher rates of preeclampsia than in other women. Those studies suggested that the condition could be related to the body’s immune response to cells it doesn’t recognize.

Klatsky and colleagues decided to start their own study to test if that pattern held true for eggs that the body would consider “foreign.”

The team of researchers compared 77 women who had given birth using donated eggs between 1998 and 2005 with 81 similar women who had gotten pregnant using IVF with their own eggs.

The researchers noted how many women in each group were diagnosed with either preeclampsia or pregnancy-related high blood pressure, as well as how many gave birth to their babies prematurely.

Their results show that about 5 percent of women who used their own eggs for IVF developed preeclampsia, compared to nearly 17 percent of women who used donor eggs. Women using donor eggs were also more likely to get high blood pressure without kidney problems and to deliver premature.

Their findings also showed that women who got pregnant using embryos that had been frozen and then thawed were more at risk for preeclampsia than women using fresh embryos. Klatsky said it’s a possible effect that is worth looking into with future studies.

Dr. Sacha Krieg, an obstetrician who studies infertility at the Kansas University Medical Center and was not involved with the study, agreed that doctors should counsel patients at increased risk for preeclampsia and monitor them more closely during pregnancy. But cautioned against trying to draw too much of a conclusion from a small study.

Krieg told Reuters Health she hopes that future studies will start with women who are just getting pregnant and track their health as they go through their pregnancy. While harder to conduct, such studies can often give researchers more accurate information.

However, both she and Klatsky hopes that the current study will give researchers more clues about how preeclampsia develops.

Having more information about the condition could help doctors “develop better treatments and better ways to prevent it, and better ways to counsel patients about their risks,” Klatsky told Reuters.

There are still signs that preeclampsia has something to do with the body’s immune response when it recognizes foreign cells. It would make sense, says Krieg. “We know that the immune response is important for both implantation and development of the fetus.”

Doctors need to learn more about how a fetus implants in the uterus, she added, because this is probably where the early stages of preeclampsia start, even if women do not show symptoms until much later.

Klatsky said the main message of the study is that doctors should be aware of possible risks to their patients, and most importantly that researchers should keep tracking the immune system response in pregnant women.

Results of the study are published in the journal Obstetrics & Gynecology. 

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Adjusting The Prostate Cancer Staging System

(Ivanhoe Newswire) — A novel study faces up to the current staging system that ultimately determines the degree or severity of prostate cancer that has not metastasized.  The study found that there is no link between localized prostate cancer’s clinical stage and a patient’s risk of cancer recurrence after having his prostate removed.

One of the central purposes of staging prostate cancers is to assist physicians in determining a patient’s prognosis.  For example, a more advanced clinical stage should indicate an elevated risk of cancer recurrence after treatment. Surprisingly, however, researchers have found that clinical stage is of questionable utility for predicting disease recurrence after surgical removal of the prostate (radical prostatectomy) in patients with localized prostate cancer.

Adam Reese, MD, of the University of California, San Francisco, and his colleagues questioned whether staging errors are accountable for this inconsistency.  In other words, do physicians often mistakenly stage prostate cancer cases, and in doing so, does this account for the differing consistency of clinical staging for predicting prostate cancer outcomes?

The investigators reported that clinical stage was allocated erroneously in 35.4 percent of 3,875 men in a multi-institutional national disease registry.  The preponderance of these staging errors occurred for the reason that physicians generally discounted the results of transrectal ultrasound tests and wrongly incorporated biopsy results when assigning stage.

Even after correcting these staging errors, nevertheless, there was no distinct connection between clinical stage and prostate cancer recurrence subsequent to radical prostatectomy.  “Our findings question the utility of our current staging system for localized prostate cancer,” which Dr. Reese was quoted as saying.

SOURCE: CANCER, 22 November 2010

Hospital Safety Not Improving, Study Claims

A new study, published Thursday in the New England Journal of Medicine (NEJM), says that efforts to make American hospitals safer over the past decade have fallen short.

A team of researchers, led by Christopher Landrigan of Boston’s Brigham and Women’s Hospital, studied a reported 2,300 patient admissions records from 10 North Carolina hospitals selected at random. They discovered that in 588 cases, patients were somehow harmed as a result of medical procedures, medications, or other related causes.

“Of 588 harms that were identified, 245 (41.7%) were temporary harms requiring intervention”¦ and 251 (42.7%) were temporary harms requiring initial or prolonged hospitalization,” Landrigan and his colleagues wrote. “An additional 17 harms (2.9%) were permanent, 50 (8.5%) were life-threatening, and 14 (2.4%) caused or contributed to a patient’s death.”

Furthermore, they reported that 63 percent of the incidents were avoidable.

“These harms are still very common, and there’s no evidence that they’re improving,” Landrigan told Reuters on Wednesday. “The problem is that the methods that have been best proven to improve care have not been implemented across the nation.”

The methods to which Landrigan was referring include computerizing patient information and prescription records, limiting the number of consecutive hours that nurses spend on the job, and implementing checklists for surgical operations and other medical procedures, according to Reuters.

The study discovered that the most common incidents involved procedural error (186 cases), medication-related problems (162 cases), and hospital-acquired nosocomial infections (87 cases). Other causes included flawed diagnostic evaluations and even falls.

The results of the study show that “harm resulting from medical care was common” and that there is “little evidence that the rate of harm had decreased substantially” from 2001 to 2007, the researchers said in their report. They added that their findings “validate concern raised by patient-safety experts in the United States and Europe that harm resulting from medical care remains very common.”

Landrigan and his colleagues said that the results were “disappointing” but “not entirely surprising”¦ Despite substantial resource allocation and efforts to draw attention to the patient-safety epidemic on the part of government agencies, health care regulators, and private organizations, the penetration of evidence-based safety practices has been quite modest.”

While the report did focus on solely on health care facilities in the North Carolina area, Landrigan told Denise Grady of the New York Times on Wednesday that it was “unlikely that other regions of the country have fared better.”

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Study: Alternative Causes Of Weight Gain

(Ivanhoe Newswire) — Fighting obesity may not be as clear cut as eating right and exercising. A recent study conducted at the University of Alabama at Birmingham demonstrates that there is much more to the obesity epidemic than meets the eye.

Led by biostatistics professor David B. Allison, Ph.D., the study began with the analysis of previous data about little primates called marmosets, which was collected at the Wisconsin Non-Human Primate Center.  The population had gradually demonstrated significant weight gain, but no obvious reason could be found to explain it.  In particular, controlled diet change appeared to have little effect on the strange occurrence.

Allison set out to find more data, looking at studies of mammals living around humans for at least ten years.  He separated his findings into 24 data sets on 12 groups of 20,000 animals.  Some of the groups were lab primates and rodents, some were domestic animals and others were strays, but one constant was observed among them all: a gradual, overall weight gain in their respective populations.  Out of the 24 sets, 23 had an increase in the amount of obese members within the groups.

“And yet there was no single through running through all 24 data sets that would explain a gain in weight,” Allison was quoted as saying.  “The animals in some of the data sets might have had access to richer food, but that was not the case in all data sets.  Some of the animals might have become less active, but others would have remained at normal activity levels.  Yet, they all showed overall weight gain.  The consistency of these findings among animals living in different environments, including some where diet is highly controlled and has been constant for decades, suggests the intriguing possibility that increasing body weight may involve some unidentified or poorly understood factors.”

Although the common culprits of increased food intake and low activity level are certainly valid, scientists are starting to look at a few alternatives.  The first is light exposure. According to various studies, eating habits are influenced by the amount of light one absorbs each day, so even small changes in exposure can make an impact.  Allison questions if the light pollution brought on by industrial age has been a factor in obesity.

A second alternative cause of obesity is viruses such as adenovirus-36, which has been linked to obesity due to the amount of AD36-fighting antibodies typically present in obese individuals.

Epigenetics are another possible cause.  These are the genetic modifications resulting from environmental factors such as stress, availability of resources, predation and climate change.  Any number of adaptive modifications could influence weight gain.

Understanding these alternative causes, and finding the many solutions needed to fight them, will require greater exploration and research.

SOURCE: University of Alabama at Birmingham, November 2010

Polar Bears Threatened With Loss Of Food Sources

A continuation of current climate trends could eliminate the primary food source of polar bears amid fierce competition with grizzly bears as the two species are forced into a shared habitat, said evolutionary biologists at the University of California, Los Angeles.

The scientists used 3-D computer modeling to compare the skull and jaw strength of polar bears and brown bears, and found that polar bears are less suited to processing the tough omnivorous or herbivorous diets of their grizzly cousins.

The findings add to growing signs of threats to polar bears as a result of climate change that scientists attribute to man-made greenhouse gas emissions.

“This is one additional piece of evidence that things look pretty bleak for the polar bear, if current trends continue,” said Graham Slater, the study’s lead author, in an interview with Reuters.

Polar bears are already are losing habitat amid rising Arctic temperatures that are depleting the sea ice they depend on to hunt for seals. As the ice continues to diminish, the bears will be forced to seek additional food sources.

“To people who say polar bears can just change their diet, we are saying … they will have to, but it probably will not be sufficient for them, especially if they are co-existing with grizzly bears,” said Blair Van Valkenburgh, the study’s senior author.

The grizzlies have begun moving north in Canada as their natural habitat grows milder.  Simultaneously, polar bears are moving farther south due to melting ice, putting the two species on a collision course towards land best suited to the grizzly.

“These two species are already starting to come into contact,” Slater added.

The polar bear is expected to lose in the growing competition for the plant life that makes up the bulk of the grizzly’s diet because they lack the skull strength and tooth size needed for chewing plants, grass, tree bark and berries, the scientists said.

“Polar bears would not be able to break up the food as well in their mouths and would not digest it as well,” Van Valkenburgh told Reuters.

Seal blubber is softer and requires less chewing, putting less strain on the skull by comparison, he added.

Grizzly bears are a subspecies of brown bears, from which the polar bears evolved relatively recently.

And while the two are closely related, the split between them occurring roughly half a million years ago in response to the swift onset of glacial climates during the ice ages.

Polar bears are a “marvelous example of rapid adaptation to an extreme environment,” Slater told Reuters.

“The fact that we can lose them equally as rapidly as a result of human-mediated climate change is rather striking.”

The study, funded by the National Science Foundation, was published November 5, 2010 in the journal of the Public Library of Science, and can be viewed at http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0013870.

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University of California, Los Angeles

School Lunch Programs Can Reverse Poor Academic Performance

School lunch programs could help reverse the negative effects of food scarcity on the academic performance of teens, according to a new study published Monday.

The researchers said the government food-assistance programs could help break the cycle of poverty in which poor children go hungry, receive poor grades, don’t advance to college and fail to escape their socioeconomic status, which results in their children repeating the cycle.

“Food insecurity is more problematic in the long term if it occurs prior to adolescence, but it doesn’t mean that adolescents are more resilient than younger children,” said study leader Christelle Roustit during an interview with Reuters.

Food insecurity is believed to weaken scholastic achievement in two ways: by depriving the body of the necessary nutrients for normal mental and physical development, and by creating an environment of stress and insecurity that diminishes a child’s desire to attend school and succeed in class.

In the current study, Roustit and her colleagues at the Research Group on the Social Determinants of Health and Healthcare in Paris, France, analyzed surveys given to 2,346 public high school students in Quebec, Canada, along with 2,000 of their parents.

The questionnaires asked about academic performance and socioeconomic status.  The survey also included several questions about food security at home, such as whether a lack of money kept the family from eating enough, or from purchasing an adequate variety of foods.

Just over 11 percent of teens reported food insecurity at home, the researchers said.  Of those, two-thirds attended schools that provided free or low-cost breakfast, lunch or snacks.  This allowed the researchers to examine the impact the meals programs had on academic performance.

Not surprisingly, the researchers found that food insecurity was strongly associated with academic problems.  However, teens with home food insecurity performed dramatically better academically if their school offered meal assistance.

These adolescents were much less likely to be held back a year, or to score poorly in language testing or to rate their overall academic performance as poor.

The data used in the study was obtained during the 1990s, but Roustit said a new survey of Quebec adolescents is now underway.

“We would be able to compare the results of 1999 to 2009 in few years,” she told Reuters.

The current recession has taken a heavy toll on food security within the U.S., with a recent report by the Department of Agriculture finding that nearly 15% of American households faced food insecurity at some point in 2009.  This is the highest level since 1995, when this measurement began being kept.

More than 31 million U.S. school children now receive free or inexpensive lunches through the National School Lunch Program under the federal Child Nutrition Act.  The program cost $9.8 billion in 2009, according to data from the U.S. Department of Agriculture.

Under the program, children from families with incomes at or below 130 percent of the poverty level ($28,665 for a family of four) are eligible for free meals, while those with incomes between 130 and 185 percent of the poverty level ($40,793 for a family of four) are eligible to receive lunch for a cost of no more than 40 cents.

U.S. teachers and school administrators say that children who participate in government food assistance programs exhibit improved behavior, and have fewer absences and better test scores.

The findings were published online November 22, 2010, in the journal Pediatrics.

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Thanksgiving Dinner A Real Food Fight For Your Teeth

Never mind conflict with the in-laws; it’s cake vs. cranberry, pie vs. wine

If you’re lucky, it will all be kisses and hugs around the Thanksgiving dinner table, with friends and family near and dear gathered about, and puppies at your feet waiting for table scraps.

But peace won’t reign within the confines of the oral cavity, where Streptococcus mutans and other harmful bacteria will await their own holiday feast. Your meal will enable S. mutans to launch one of its biggest assaults of the year on your tooth enamel.

New work by dental researchers at the University of Rochester Medical Center brings both good and bad news. While bacterial forces in your mouth will exploit your delectables in newly discovered ways, some foods common at the holiday dinner table ““ like the cranberry and even wine ““ offer new leads in the effort to stop tooth decay.

The Thanksgiving Day battle for oral health hinges on microbes like S. mutans. Most cookies, pies and the like contain mountains of sugar, but it’s not the sugar itself that causes tooth decay. Rather, S. mutans and other bacteria in our mouths ““ billions of individual microbes all waiting for their next snack ““ feast on the sugars, stick on your teeth and then churn out acid that eats away at tooth enamel.

At the front lines is Hyun “Michel” Koo, D.D.S, Ph.D., a dentist turned food scientist and microbiologist who is both exploring the destructive power of S. mutans and scouring foods and natural substances to harness their ability to prevent cavities. With every portion of bad news he delivers about cavities comes good news about compounds that may help prevent tooth decay.

“Natural substances offer tremendous possibilities for stopping tooth decay,” said Koo, who earlier this year received a $1.6 million from the National Institute of Dental and Craniofacial Research to conduct his research. “Our time spent in the laboratory is aimed at harnessing the potential of some of these compounds, perhaps eventually incorporating them into a toothpaste or mouth rinse to stop dental decay.”

Good news at the dinner table

Koo is hot on the trail of the cranberry as a potential ally in the fight against S. mutans, which is a threat to our teeth primarily because of its ability to form plaque. What appears to us as sticky white gunk along our teeth is actually a formidable fortress of molecules known as glucans ““ building blocks of plaque, stacked like bricks in a wall, rife with bacteria. It’s a gunky fortress that covers the tooth and gives bacteria a safe haven to munch on sugar, thrive, and churn out acid.

Koo has discovered that compounds within the cranberry disrupt enzymes known as glucosyltransferases that bacteria use to build glucans. Without its glucans, S. mutans and other bad bacteria in plaque becomes vulnerable.

Together with Nicholi Vorsa, Ph.D., director of the Philip E. Marucci Center for Blueberry and Cranberry Research and Extension at Rutgers University, Koo is working to isolate the compounds within the cranberry that are most protective. The pair has identified molecules known as A-type proanthocyanidins as having potential to reduce cavities dramatically. Earlier this year in the journal Caries Research, the team reported that when the molecules were applied, glucan and acid production by S. mutans was reduced by up to 70 percent, and cavity formation in rats was slashed by up to 45 percent.

“Maintaining the natural balance of resident flora in the oral cavity is important for keeping opportunistic pathogens in check,” said Koo, a researcher in the Center for Oral Biology and an associate professor in the Eastman Institute for Oral Health and the Department of Microbiology and Immunology. “These molecules don’t outright kill S. mutans. Instead, they disrupt the two most harmful actions of this pathogenic organism, acid production and glucan production.”

More good news

More good news comes from that delicious glass of wine, or at least the waste in its wake. With funding from the U.S. Department of Agriculture, Koo began a research project with Olga I. Padilla-Zakour, Ph.D., associate professor of Food Processing at the New York Agricultural Experiment Station of Cornell University. They found that the abundant waste from the red-wine-making process ““ materials such as fermented seeds and skins collectively known as pomace that are cast away after grapes are pressed ““ contains compounds that fight S. mutans. In particular, some polyphenols can inhibit the activity of S. mutans’ crucial enzymes by as much as 85 percent and also reduce the amount of acid the bacteria produce.

And the bad news

Last month in PloS One, Koo showed that S. mutans is even more powerful than scientists have realized, responding readily to changing environmental conditions in the presence of starch and sucrose to thrive in the mouth.

In work led by Marlise Klein, D.D.S., Ph.D., research assistant professor, Koo’s team analyzed the activity of more than 300 genes in S. mutans under changing conditions. The team found that certain key proteins boost their activity dramatically in the presence not only of sugar but also complex carbohydrates derived from starch digestion. Once the body’s own amylase enzymes naturally present in saliva break down starches, S. mutans kicks its glucan-forming machinery into high gear.

“The new research shows how two pillars of the modern diet, starch and sugar, can work cooperatively to bring about tooth decay,” said Koo. “A cookie, sugar-covered doughnut, or a piece of pie filled with both sugar and starch provide the perfect recipe for the bacteria that destroy teeth.”

Even when the amount of sugar was slashed in half, certain genes central to the ability of S. mutans to create its formidable glucan fortress boosted their activity five-fold in the presence of starch-derived carbohydrates. That enabled the bacteria to create plaque that is hardier, stickier, and capable of producing more acid than plaque created without significant starch present.

On Thanksgiving Day “¦”¦

Koo notes people shouldn’t simply eat more cranberry sauce or drink more wine to try to prevent cavities. His work is aimed at identifying and then exploiting specific compounds that give the benefit without, for instance, the high levels of acidity or the added sugar that cranberry products might include. Rather, at this point, everything your dentist keeps telling you remains the best advice to prevent cavities.

“On Thanksgiving Day, like any day, brush your teeth, avoid foods filled with sugars as best you can, and don’t snack often ““ and if you do, brush your teeth again,” said Koo. “Consider using a mouth rinse, get some fluoride in there ““ and be sure to see a dentist regularly.”

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New Children’s Benadryl, Motrin Recalls Issued

Johnson & Johnson (J&J) has issued yet another recall of children’s medication, this time issuing a voluntary recall of Children’s Benadryl allergy tablets and Junior Strength Motrin pain reliever/fever reducer caplets, according to various media reports Tuesday.

The voluntary recalls were issued by J&J’s McNeil Consumer Healthcare division on November 15 and include the cherry and grape flavors of Children’s Benadryl FASTMELT tablets and 24-count Junior Strength Motrin caplets, according to the McNeil Product Recall website.

According to Bloomberg reports, some 4 million packages of the allergy medication and over 800,000 bottles of the pain reliever have been affected. Both products were distributed in the United States, while the Benadryl was also sold in Belize, Barbados, Canada, Puerto Rico, St. Martin, and St. Thomas.

“This is a wholesale and retail level recall. No action is required by consumers or healthcare providers and consumers can continue to use the product,” the company said in a statement. “The recall was initiated after a review”¦ revealed insufficiencies in the development of the manufacturing process. There is no indication that the recalled products do not meet quality standards, and this recall is not being undertaken on the basis of adverse events.”

Also on November 15, McNeil Consumer Healthcare issued a recall for 36-count packages of Cherry-flavored Rolaids Extra Strength Softchews antacids. According to the recall website, the action was triggered as a precaution following consumer complaints. Like the Benadryl and Motrin recalls, the company is identifying this as a wholesale and retail level recall, requiring no action from consumers and healthcare providers.

“Consumers can continue to use the product,” the company said in a statement.

These are the latest in a series of recalls to his Johnson & Johnson. In October, a recall was issued for one lot of Tylenol 8-Hour caplets sold in the U.S. and Puerto Rico. Over the summer, Tylenol Extra Strength, Tylenol PM, Children’s Tylenol Meltaways, Benadryl Ultratab Tables, and Motrin IB products were recalled, and in April, recalls were issued for multiple varieties of infants’ and children’s Tylenol, Motrin, Zyrtec, and Benadryl products.

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‘Rosetta Stone’ For T-dwarf Stars Discovered

An international team of astronomers have discovered a unique and exotic star system with a very cool methane-rich (or T-) dwarf star and a “Ëœdying’ white dwarf stellar remnant in orbit around each other. The system is a “ËœRosetta Stone’ for T-dwarf stars, giving scientists the first good handle on their mass and age.

The team, led by Dr Avril Day-Jones of the Universidad de Chile and including Dr David Pinfield of the University of Hertfordshire as well as astronomers from the University of Montreal, publish their results in the journal Monthly Notices of the Royal Astronomical Society.

The system is the first of its type to be found. The two stars are low in mass and have a weak mutual gravitational attraction as they are separated by about a quarter of a light year or 2.5 trillion km (to put this in context Neptune is only 4.5 billion km from the Sun). Despite the frailty of the system it has stayed together for billions of years, but its stars are cooling down to a dark demise.

Methane dwarfs are on the star / planet boundary and are about the size of the giant planet Jupiter. They have temperatures of less than 1000 degrees Celsius (in comparison the Sun’s surface is at 5500 degrees Celsius). Methane is a fragile molecule destroyed at warmer temperatures, so is only seen in very cool stars and objects like Jupiter. Neither giant planets nor T-dwarf stars are hot enough for the hydrogen fusion that powers the Sun to take place, meaning that they simply cool and fade over time.

White dwarfs are the end state of stars similar to and including the Sun. Once such stars have exhausted the available nuclear fuel in their cores, they expel most of their outer layers into space forming a remnant planetary nebula and leaving behind a hot, but cooling core or white dwarf about the size of the Earth. For our Sun this process will begin about 5 billion years in the future.

In the newly-discovered binary, the remnant nebula has long since dissipated and all that is left is the cooling white dwarf and methane dwarf pair.

Dr Day-Jones puts this in context, commenting, “In about 6 billion years’ time, when our Sun ‘dies’ and becomes a white dwarf itself, the stars in the newly-discovered system will have changed dramatically. The methane dwarf will have cooled to around room temperature, and the white dwarf will have cooled to 2700 Celsius or the temperature of the methane dwarf at the start of its life”.

This binary is providing a crucial test of the physics of ultra-cool (temperatures less than 1000 degrees Celsius) stellar atmospheres because the white dwarf lets us establish the age of both objects. It calibrates properties of the methane dwarf such as its mass, making it a kind of “ËœRosetta Stone’ for similar stars with complex, hazy ultra-cool atmospheres.

The methane dwarf was identified in the UKIRT Infrared Deep Sky Survey (UKIDSS) as part of a project to identify the coolest objects in the galaxy. Its temperature and spectrum were measured by the Gemini North Telescope in Hawaii.

The team then found that the methane dwarf shares its motion across the sky with a nearby blue object catalogued as LSPM 1459+0857. They studied the blue object using the world’s largest optical telescope, the European Southern Observatory’s Very Large Telescope (VLT) in Chile. The new VLT observations revealed the blue object to be a cool white dwarf and companion to the methane dwarf. The objects were thus re-christened LSPM 1459+0857 A and B.

The two stars are today separated by at least 2.5 trillion km, but would have been closer in the past before the white dwarf was formed. Once the star that formed the white dwarf reached the end of its life and expelled its outer layers, the loss of mass weakened the gravitational pull between the stars, causing the methane dwarf to spiral outwards to create the gravitationally fragile system that we see today. But the current age of the white dwarf indicates that this system has survived for several billion years. So the new discovery shows that despite their fragility, such binaries are able to remain united even as they move through the maelstrom of the disc of our Galaxy.

“Binary systems like this provide vital information and allow us to better understand ultra-cool atmospheres and the very low-mass dwarfs and planets they enshroud” says Dr Pinfield. “The fact that these binaries survive intact for billions of years means that we could find many more lurking out there in the future.”

Reference: “Discovery of a T dwarf + white dwarf binary system”, A. C. Jones et al, Monthly Notices of the Royal Astronomical Society, in press.

Image Caption: An artist’s impression of the binary as it might appear from a point in space near the methane dwarf. From here the distant white dwarf would appear as a bright star, only gently illuminating its cooling companion. Credit: Andrew McDonagh

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Daydreaming Linked To ADHD Gene

(Ivanhoe Newswire) — A recent study finds a gene linked to attention deficit hyperactivity disorder (ADHD) leads to daydreaming.  Researchers believe these findings are the first to show ““ through brain scanning ““ the dissimilarities in the brain network relationships between individuals with this specific form of gene and others with a different form.

“Our goal is to narrow down the function of candidate genes associated with ADHD, and in this study, we find this gene is tied to competition between brain networks.  This could lead to increased inattention, but it likely has nothing to do with hyperactivity,” which the study’s lead author, Evan Gordon, a doctoral candidate in the interdisciplinary program in neuroscience at Georgetown University Medical Center, was quoted as saying.  “This is just one gene, and it does not cause ADHD but likely contributes to it. The disorder is believed to be due to a myriad of genetic factors.”

DAT1 is the gene in question. Its protein produces the dopamine transporter that aids in regulating dopamine transmission between brain cells.  Furthermore, the DAT1 gene comes in two alleles (forms): DAT1 10 and DAT1 9.  Individuals who inherit two 10 alleles (10/10) are at greater risk for developing ADHD than those who inherit one of each allele (10/9).  Gordon adds that people rarely inherit two 9 alleles, and that the 10 allele is more frequent than the 9 allele.

The biological significance in regards to inheriting a DAT1 10 allele is that the brain produces excess quantities of dopamine transporters, which results in less dopamine signaling between neurons.  If too many dopamine transporters scoop up the dopamine released by those neurons, then fewer of them are able to actually reach other neurons and pass on a signal.  If there are fewer transporters, more dopamine stays in the synapse between neurons, resulting in a triggered reaction.

The dopamine is important for “gating” the transfer of information between brain regions ““ allowing or preventing new information to come in.  “The belief is that dopamine helps teach certain brain regions how and when to gate, and that 10/10 carriers are not gating as quickly or effectively as is possible,” Gordon said.   That is exactly what the researchers discovered when they used functional MRI (fMRI) on 38 individuals who participated in the study.  Half of the groups were 10/10 carriers and half were 10/9 carriers; none of them were diagnosed with ADHD.

Researchers ultimately investigated the activity in two areas of the brain, the default mode network (DMN) ““ associated with mind wondering or daydreaming ““ and task-positive networks (TPNs) ““ which are triggered and stay active during problem solving as well as other cognitive work.  In the study, participants were asked to remember letters they saw on a screen inside the fMRI machine, and to recall them, thus activating TPNs.

Scanning determined that in 10/10 carriers, the mind wandering areas tended to communicate with regions engaged in memory tasks much stronger than it did in 10/9 carriers.

“Dopamine in the 10/10 carriers was not doing a good enough job in preventing the mind wandering regions from interfering with memory performance regions, resulting in less efficient cognition,” Gordon adds.

They also found no differences between genotype when the participants were at rest after their memory tasks.  “That tells us that the DAT1 genotype affects gating only when release of dopamine is high, such as during a memory task, and that less dopamine signaling leads to increased inattention,” he concluded.

SOURCE: Annual Meeting of the Society for Neuroscience, November 2010

Dead Sea May Boost Understanding Of Future Climate

A research team drilling into the bed of the Dead Sea hopes to uncover a half a million years of history and potential secrets of past climate change and natural disasters.

According to a Reuters report, the engineers and scientists began extracting layers of the earth’s core on Sunday, and will continue to drill for about two months until they reach a depth of 4,000 feet below sea level.

“The sediments of the Dead Sea are the best climate and earthquake recorders for the entire Middle East,” project head Zvi Ben-Avraham of the Israel Academy of Sciences told the news agency.

The Dead Sea, which is nearly 1,400 feet below sea level, collects water run-off from Egypt’s Sinai desert up to the Golan Heights, an area of around 26,000 square miles, providing plenty of material for climate research, Ben-Avraham said.

It is also on a fault line between two continental plates moving at different speeds, causing tectonic activity.

Ben-Avraham said the sea bed is like a tree that has growth rings; it adds two layers of sediment every year. The team will study 500,000 years worth of geological history that could help them understand the future.

From the extracted layers of sediment, the team hopes to find information on ancient rainfall, floods and droughts, and even earthquakes that can be used in studies on how to best deal with global warming.

Scientists and environmentalists have also been rushing in recent years to find a solution to the lake’s receding shoreline, for which many experts blame regional water mismanagement. The team hopes drilling will provide some historical insight.

The project is part of the International Continental Drilling Program, which has drilled dozens of holes all across the globe in an effort to find the best way to manage the earth’s resources and environment.

Scientists from around the world are involved in the Dead Sea drilling project, Ben-Avraham said.

Utah-based DOSECC, a non-profit corporation, was awarded the task of drilling, operating both day and night. It will drill a 2-inch-wide hole, which is smaller than those used to find oil. The drilling will continue until they reach 1600 feet, said operations manager Beau Marshall. Samples will be analyzed and archived, he said.

“We’ve drilled a lot of fresh water lakes, we’ve done some salt water activity as well, but the Dead Sea is quite unique,” Marshall told Reuters.

“It’s going to require us to keep everything well lubricated and cleaned up because the salt will wreak havoc on our equipment,” he said.

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Babies And Robots Learn From Each Other

Interdisciplinary research combines infant learning and computer science

A few years ago, AnthroTronix, Inc., an engineering research and development firm in College Park, Md., introduced Cosmobot, a type of social robot for therapists and educators who work with developmentally and learning disabled children.

By imitating human joint movement in its shoulders, arms, hands and head, Cosmobot motivates children to develop new skills more quickly than is typical with traditional therapy. Supported in part by the National Science Foundation’s (NSF) Small Business Innovation Research Program, scientists developed the assistive social robot primarily to work with children ages 5-12, including those with autism and cerebral palsy.

But why does this work? Why do children respond so favorably to educational programs taught by technology?  And when the technology is a robot made from inanimate materials, how do children learn to distinguish between the robot and a living thing?

The answer, it turns out, may have far-reaching implications for interaction with “social” robots for both children and adults.

Working with a group of 18-month-old toddlers and a metallic robot, a team of scientists from the University of Washington (UW) recently determined that it is not only what something looks like, but how it moves and interacts with others that give even inanimate objects social significance. In fact, they say these characteristics give lifeless objects meaning to all humans regardless of age.

Their interdisciplinary experiment was funded in part by the LIFE Center at the University of Washington, which is part of NSF’s Science of Learning Center program.

“Over the past 10 years, research in developmental science has taught us that social interaction is important for children’s learning,” said project co-director psychologist Andrew Meltzoff of UW’s Institute for Learning & Brain Sciences.

But what makes something “social?” Meltzoff’s group has a particular interest in this question not only because it is relevant to children with autism, but also because of its importance for typical child development and the design of new learning technologies. “It is not so much what an entity looks like–its physical features–or even how it moves, but how it interacts and reacts that is important to a child,” he said.

UW computer scientist and co-director of the project Rajesh Rao agreed. “From a robotics point of view, the results shift the emphasis from designing robots that look like humans to robots that can interact credibly with humans,” he said applying the findings to his particular area of building adaptive robotic systems.

The research team programmed a metal robot named Morphy to copy some basic human social skills and designed an experiment to see if 18-month-olds would interact with it. During the experiment, 64 babies individually sat on their parents’ lap facing Rechele Brooks, a co-author of the UW study. The babies played with toys for a few minutes to get used to the environment and then Brooks revealed Morphy, who was hidden behind a barrier.

Following a script, Brooks said, “Oh, hi! That’s our robot!” and asked Morphy if it wanted to play a game.  Controlled by a researcher hidden from the baby, Morphy responded by waving its arms and shaking its head. Brooks then asked, “Where is your tummy?” and “Where is your head?” and the robot pointed to its torso and head. Then Brooks demonstrated arm movements and Morphy imitated them. All the while, the babies watched, looking back and forth as if at a ping pong match.

Then when Brooks excused herself from the room, researchers measured whether the baby would interact with and take cues from the robot as if it was a sentient being. When the robot looked at a toy in the room, 13 out of 16 babies, who had watched the robot play with Brooks, followed the robot’s gaze as compared to a control group in which babies did not see Morphy engage in games. Only 3 of 16 of these babies turned to where the robot was looking.

“Remember, the robot did not directly interact with the child. The child simply observed as the adult and the robot communicated,” said Meltzoff.  “Yet, they were deeply influenced by what they saw.”

Traditional theories picture infants learning about space, objects, causality, and time by playing alone. But newer theories suggest that when they’re born, young children are prepared to learn from so-called social agents, who are other members in a group or society who pass on skills, values, beliefs, knowledge and modes of behavior through social interaction. Findings and theories also suggest this type of social interaction is also important over a person’s lifetime.

Computer scientists are using this knowledge to fashion acceptable robots that can assist people from childhood well into adulthood.

“The research places important constraints on the design of companion robots and provides clues as to what aspects of human behavior robotics researchers will need to focus on,” said Rao.

So-called “companion robots” have a number of potential applications, ranging from helping and caring for the elderly and disabled to doing household chores and acting as playmates or personalized tutors for children. But robotics researchers have long wondered how human-like in appearance they need to be for adults to accept them.

The study indicates that more than appearance, robots will need to possess sophisticated cognitive abilities such as being able to understand speech and imitate human actions in order to pass the test of human social acceptance. The specific set of movements or gestures a robot should have will depend on a number of factors such as the domain in which it operates–whether the robot is an emergency responder or a child’s tutor, for example.  Programming for local culture also is important for determining whether humans will interact with it.

“Some skills such as being able to interact through speech and understand a human’s intentions are universally applicable to all robots that interact with humans,” said Rao. “Other skills will need to be learned on-the-fly, which is one of the reasons why we have focused our robotics research on learning by imitating humans.”

The relationship between Meltzoff’s work and Rao’s work appears to be quite symbiotic with children learning from robots and robots learning from children.

Robots were a crucial help to Meltzoff. “We were able to ‘manipulate the stimulus’ to investigate the key features of sociality,” he said. “In short, if you want a child to learn from a robot, and possibly other types of technology, designers are best advised to infuse it with social characteristics.

“We are making headway into specifying those parameters in some useful detail.  For a variety of technical reasons we could not do this with dolls, puppets, or trained human actors. The robots were the key.”

Meanwhile, during the last five years, Rao’s group has been developing methods by which humanoid robots can learn new skills by observing humans directly. “Our approach to building robots that learn is inspired by how children learn from watching and imitating adults or other children,” he said. “Such an approach provides a flexible and powerful way of programming robots through demonstration.”

“When we know “Ëœwhat makes a social agent’ for a child, we may be able to embody the key features in technology to help children learn,” Meltzoff said. “We may be able to make technology more social for children, especially for elementary school children, who are quite curious about all kinds of technology and can profit from it.”

The researchers say they’re not suggesting robot nannies, but the basic principles of learning they’re uncovering from infant-robot interaction has implications for future robot use. As the project moves forward, the Seattle infant-robotics team will conduct a range of studies using social robots to investigate social cognition in typical children and children with autism.

“We hope to illuminate the basic mechanisms of social-cognitive development, and with our colleagues in clinical psychology, may be able to contribute to more effective diagnoses and treatment interventions for children with autism,” said Meltzoff.

The goal of the NSF-supported Science of Learning Centers is to foster interdisciplinary research on learning and to conduct basic research on the science of learning and apply it in the real world.

By Bobbie Mixon, National Science Foundation

Image Caption: A team of scientists from the University of Washington co-led by psychologist Andrew Meltzoff and computer scientist Rajesh Rao recently determined that it is not only what something looks like, but how it moves and interacts with others that gives even inanimate objects social significance. Credit: Mary Levin, University of Washington

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Vitamin C: A Potential Life-Saving Treatment For Sepsis

Physicians caring for patients with sepsis may soon have a new safe and cost-effective treatment for this life-threatening illness. Research led by Dr. Karel Tyml and his colleagues at The University of Western Ontario and Lawson Health Research Institute have found that vitamin C can not only prevent the onset of sepsis, but can reverse the disease.

Sepsis is caused by a bacterial infection that can begin anywhere in your body. Your immune system goes into overdrive, overwhelming normal processes in your blood. The result is that small blood clots form, blocking blood flow to vital organs. This can lead to organ failure. Babies, the elderly and those with weakened immune systems are most likely to get sepsis. But even healthy people can become deathly ill from the disease.

According to Dr. Tyml, a professor at Western’s Schulich School of Medicine & Dentistry, patients with severe sepsis have a high mortality rate, nearly 40 percent, because there is no effective treatment.

“There are many facets to sepsis, but the one we have focused on for the past 10 years is the plugging of capillaries,” says Dr. Tyml. Plugged capillaries prevent oxygenation and the supply of life-supporting materials to your organ tissue and stop the removal of metabolic waste product. Plugged capillaries are seen in organs of septic patients. These organs may eventually fail, leading to multiple organ failure and death. Dr. Tyml’s lab was the first to discover this plugging by using intravital microscopy, a technique Dr. Tyml pioneered in Canada.

According to Dr. Tyml’s most recent publication, oxidative stress and the activated blood clotting pathway are the major factors responsible for the capillary plugging in sepsis. Through his research, Dr. Tyml has discovered that a single bolus of vitamin C injected early at the time of induction of sepsis, prevents capillary plugging. He has also found that a delayed bolus injection of vitamin C can reverse plugging by restoring blood flow in previously plugged capillaries.

“Our research in mice with sepsis has found that early as well as delayed injections of vitamin C improves chance of survival significantly,” explains Dr. Tyml. “Furthermore, the beneficial effect of a single bolus injection of vitamin C is long lasting and prevents capillary plugging for up to 24 hours post-injection.”

Dr. Tyml and his colleagues are eager to find appropriate support to move this research from the bench to the bedside to see if these findings translate to patients with sepsis.

The potential benefit of this treatment is substantial. “Vitamin C is cheap and safe. Previous studies have shown that it can be injected intravenously into patients with no side effects,” says Dr. Tyml. “It has the potential to significantly improve the outcome of sepsis patients world-wide. This could be especially beneficially in developing countries where sepsis is more common and expensive treatments are not affordable.”

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Post-Traumatic Stress Disorder Linked To Death, Atherosclerosis In Veterans

Study Highlights:

    * Veterans with post-traumatic stress disorder (PTSD) have more than double the risk of death from any causes and a higher risk of cardiovascular death compared to veterans without the syndrome.
    * Greater calcium buildup in the arteries among those with PTSD may be the reason for the greater risk of death.
    * PTSD may be an independent risk factor for cardiovascular disease, and veterans who suffer from it should receive early evaluation and aggressive treatment of cardiovascular risk factors.

Post-traumatic stress disorder (PTSD) more than doubles a veteran’s risk of death from any cause and is an independent risk factor for cardiovascular disease, according to research presented at the American Heart Association’s Scientific Sessions 2010.

PTSD is more than a psychological disorder, and the study suggests that physicians should provide early and aggressive evaluation and treatment of cardiovascular risk factors in patients with PTSD, said Naser Ahmadi, M.D., M.S., and Ramin Ebrahimi, M.D., co-principal investigators of the study. PTSD is a cluster of symptoms that can include emotional numbing, avoidance of certain situations, hyperarousal, sleep disruptions and impaired concentration.

“This study for the first time appears to point to the mechanism for the cardiovascular part of that excess mortality risk: accelerated atherosclerosis,” said Ahmadi, a research scientist at the Greater Los Angeles Veterans Administration (VA) Medical Center. “Our trial is the first to make a direct association between PTSD and atherosclerotic coronary disease as measured by coronary artery calcification (CAC), a standard test that is commonly used in studies such as ours because it can be measured non-invasively.”

Researchers studied the electronic medical records of 286,194 veterans (average age 63, 85.1 percent male) treated at VA medical centers in southern California and Nevada. The veterans participated in conflicts dating back to the Korean War.

During an average follow-up of nearly 10 years and after adjusting for age, gender, and common cardiovascular risk factors, the researchers found that veterans diagnosed with PTSD had 2.41 times the rate of death from all causes compared to non-PTSD veterans “” making PTSD an independent predictor of death from all causes.

PTSD patients made up 10.6 percent (30,460) of the entire group of veterans, but 28.9 percent of veterans who died had PTSD, said Ahmadi, who is also a member of the research faculty at the Greater Los Angeles VA Health Care System.

In a 637-veteran sub-study that used a non-invasive technique to measure the amount of coronary artery calcium, researchers found that 76.1 percent of veterans with PTSD showed at least some CAC, compared to 59 percent of non-PTSD veterans. As a group, the PTSD veterans had more severe disease of their arteries with an average CAC score of 448 compared to 332 in non-PTSD veterans.

The researchers sorted the subgroup according to their calcium buildup. After controlling for known cardiovascular risk factors and mental status, they found that at every level of calcium buildup, the PTSD veterans had a higher risk of all-cause mortality. Among veterans with calcium buildup, those with PTSD had a 48 percent greater risk of death from any cause and a 41 percent greater risk of death due to cardiovascular disease compared to non-PTSD veterans.

“The current PTSD treatment protocol is to provide relief of symptoms alone,” Ahmadi said. “PTSD is a very debilitating disorder. It makes the patient feel hopeless. These patients constantly struggle with many different (psychological) problems.”

The study’s findings are important because they show that PTSD predicts death independently of known cardiovascular risk factors, Ahmadi said. “We also believe we have found a mechanism by which PTSD could increase the risk of cardiovascular events via atherosclerosis. If we focus on early detection and management of cardiovascular risk factors in veterans with PTSD, we might be able to delay the onset of cardiovascular disease.”

Co-authors are Fereshteh Hajsadeghi, M.D.; Harmoz Babaei Mirshkarlo, M.D.; Rachel Yehuda, Ph.D.; and Ramin Ebrahimi, M.D. (co-principal investigator). Author disclosures are on the abstract.

The study received no outside funding.

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Nurse Practitioner-Led Spinal Clinic Produced Impressive Results And Shorter Waiting Times

Study reports 100 percent agreement on clinical diagnosis and 96 percent patient satisfaction

Ninety-six per cent of patients with back problems were satisfied with the assessment carried out by a specially trained nurse practitioner, according to a study in the December issue of the Journal of Advanced Nursing.

Seventy-four per cent were happy to see her rather than wait up to a year to see a surgeon, with less than a quarter of those who preferred to see a surgeon saying that the extra wait was acceptable.

The pilot study at Toronto Western Hospital in Ontario, Canada, was judged a resounding success after nurse practitioner Angela Sarro came up with exactly the same clinical diagnosis as orthopaedic spine surgeons Dr Yoga Raja Rampersaud and Dr Stephen Lewis in 100 per cent of the 177 patients she assessed. She also suggested the same management plan as the two surgeons in 95 per cent of cases.

“Waiting times for specialty consultations in public healthcare systems worldwide are lengthy and impose undue stress on patients waiting for further information and management of their condition” says Angela Sarro. “Back pain can be very unpleasant and debilitating and 85 per cent of us will experience it at some point in our lives.

“According to the College of Family Physicians of Canada, 57 per cent of people in Canada waited longer than four weeks for specialty care in 2006, compared with 60 per cent in the USA, 46 per cent in Australia, 40 per cent in the UK, 23 per cent in Germany and 22 per cent in New Zealand.

“The aim of our study was to see whether a clinic led by a nurse practitioner could speed up the diagnosis and management of patients with certain spinal conditions pre-selected by the surgeons’ offices.”

The 96 male and 81 female patients ranged from 23 to 85 years of age, with an average age of 52. All had been referred by their family doctor with suspected disc herniation, spinal stenosis or degenerative disc disease.

Key findings included:

    * Overall satisfaction was very high (96 per cent), with the nurse practitioner consultation scoring 97 per cent and the thoroughness of the examination scoring 94 per cent. Just over nine out of ten patients (91 per cent) understood their condition better after seeing the nurse practitioner.

    * Patients waited ten to 21 weeks to see the nurse practitioner, with an average wait of 12 weeks. This compared with ten to 52 weeks to be seen by the surgeons in a conventional clinic, with average waiting times ranging from three to four months for disc herniations to eight to twelve months for spinal stenosis.

    * Just over a quarter of the patients (26 per cent) said that they would have preferred to have been seen by a surgeon in a conventional clinic, but 77 per cent of those patients would not have been prepared to wait an extra three to four months to do so.

    * Just under ten per cent (18 patients) were correctly identified as surgical candidates by the nurse practitioner. In addition, 66 were referred for specific nerve root block, 14 for facet block and 26 for further radiological imaging.

“Nurse practitioners are nurses who have received additional specialist training” explains Angela Sarro. “They typically work in healthcare centres and primary care practices in the community, but their role is advancing into areas such as emergency departments and long-term care settings.

“At the moment there are clinical, legal and funding barriers in the Canadian health system that prevent nurse practitioners from being fully independent when it comes to assessing and managing patients who require specialist care.

“However, we feel that there may be scope for government-funded triage clinics led by nurse practitioners to reduce waiting times for spine consultations.

“This initiative would expand the role of the nurse practitioners and provide faster consultation and improved health outcomes for patients, families and communities.”

Co-author Dr Yoga Raja Rampersaud adds: “We believe that our study demonstrates that nurse practitioners can play an effective and efficient role in delivering timely healthcare to patients requiring specific disease management in a specialty setting.

“Although skill levels will vary from one nurse practitioner to another, physicians can work with them to help them to develop expertise in their specialty area. Ongoing evaluation is also important to ensure that quality of care is maintained and that patients are satisfied with the consultation.”

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FDA Could Ban Caffeinated Alcoholic Beverages

U.S. regulators are expected to ban the sale of alcoholic drinks that contain caffeine amid rising safety concerns.

The Wall Street Journal reported that alcoholic beverages like Four Loko and Joose will no longer be able to contain caffeine under a series of regulatory actions expected from the Food and Drug Administration (FDA) and other agencies this week.

Phusion Projects LLC, the maker of Four LoKo, said Tuesday that it would remove the stimulants caffeine, guarana and taurine from its products nationally.

“We are confident that we will continue to grow our brands and remain innovative,” Chris Hunter, a co-founder of Phusion Projects, said in an interview with the Journal.

He said that the company’s contract manufacturers already have stopped making caffeinated versions of Four Loko.  He also said that Phusion is taking the step after trying unsuccessfully “to navigate a difficult and politically charged regulatory environment at both the state and federal levels.”

United Brands Co., the maker of Joose, said it plans to follow the new regulations.  Chief Executive Michael Michail said the San Diego, California company would continue to “market Joose products in a legal and responsible manner.”

The federal restrictions follow a series of hospitalizations and deaths blamed in part of Phusion’s drinks.  Its Four Loko beverage comes in a colorful 23.5-ounce can and contains up to 12% alcohol by volume.

Senator Charles E. Schumer (D., N.Y.) said in a statement to the Journal that the FDA plans to rule that caffeine is an unsafe food additive for alcoholic beverages.

The FDA has been reviewing the safety of malt beverages, vodkas and other alcoholic beverages infused with stimulants including caffeine for about a year.

The FDA plans to notify manufacturers of the drinks that “they are engaged in the potential illegal marketing of unsafe alcoholic drinks,” Schumer said.

The new restrictions could have the greatest impact on Phusion Projects because its Four Loko generates about $200 million in annual sales according to Beer Marketer’s estimates.

Phusion Projects says it markets its products responsibly and that consumers combine alcohol and caffeine safely in mixed drinks like rum-and-coke.  The company said on Sunday that it would start selling a non-caffeinated version of Four Loko in New York.

“We’re not turning a deaf ear to what’s going on,” Jaisen Freeman, a co-founder of Phusion Projects, said in a statement Sunday after the New York state accord was disclosed.

According to an ABC report, Jason Keiran, a 20-year-old college student, died after becoming wired and drunk after drinking at least three cans of the energy drink Four Loko.  This would be equivalent of 18 light beers and 6 cups of coffee.

The Keiran’s attorney said the Florida State sophomore picked up a friend’s gun after partying with his roommates for 30 hours straight on September 17.

“They say he started to act crazy. He pointed the gun at his head and everyone else. He said ‘I realize I’m freaking you guys out take the gun away from me,'” attorney Don Van Dingenen told ABC news.

The Keirans said that they believe the drink caused their son to become so manic and erratic that he accidentally shot himself.

The makers of Four Loko had no comment on the Keirans’ lawsuit, but told ABC that they condemned underage drinking, adding that their product was intended for only adults.

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Bioengineers Provide Adult Stem Cells With Friendly Environment: Simultaneous Chemical, Electrical And Mechanical Cues

Bioengineers from the University of California, San Diego have achieved the “Triple Crown” of stem cell culture ““ they created an artificial environment for stem cells that simultaneously provides the chemical, mechanical and electrical cues necessary for stem cell growth and differentiation. Building better microenvironments for nurturing stem cells is critical for realizing the promises of stem-cell-based regenerative medicine, including cartilage for joint repair, cardiac cells for damaged hearts, and healthy skeletal myoblasts for muscular dystrophy patients. The advance could also lead to better model systems for fundamental stem cell research.

This work appears in a paper published online in Advanced Functional Materials on November 13.

While researchers have already created artificial environments for stem cells that provide chemical cues combined with either mechanical or electrical cues, the UC San Diego bioengineers say this is the first material reported in the scientific literature, to the best of their knowledge, that simultaneously provides all three cues to stem cells in a three dimensional supportive environment. Remarkably, the development of the new material was led entirely by bioengineering undergraduate students at UC San Diego.

In nature, stem cells communicate with other cells and with the extracellular matrix through chemical, electrical, and mechanical cues. “We mimicked all these cues that the native environment provides to the cells. This work is therefore fundamental to creating more life-like environments for stem cells in order to steer stem cells toward specific cell types such as chondrocytes, osteoblasts, myoblasts or cardiomyocytes,” said Shyni Varghese, the bioengineering professor who advised the student researchers working in her Biomimetic Polymers and Stem Cell Engineering laboratory at the UC San Diego Jacobs School of Engineering.

Realistic in vitro microenvironments for stem cells would also serve as excellent model systems for systematically studying cell function, signaling pathways, disease progression, and tissue growth and development.

Multifunctional Gel Matrix

The stem cells are embedded in a gelatin-like hydrogel bathed in an electrolyte solution compatible for cell growth. When an electric potential passes through the hydrogel, the gel bends and exerts mechanical strain on the cells that is designed to mimic the mechanical cues stem cells experience in natural microenvironments.

“Our hydrogel provides the chemical cues, and when you expose them to an electric field, the hydrogel surrounding the stem cells bends, which provides mechanical strain to the cells,” said Varghese.

In the new paper, the bioengineers report results of human bone marrow derived mesenchymal stem cells growing in the new microenvironment. The chemical, electrical, and mechanical cues steered the embedded cells to differentiate into cartilage cells.

The researchers continue to improve their system, with the goal of coaxing healthy tissue from stem cells. “The ultimate goal of regenerative medicine is to make healthy tissues and differentiated cells with regenerating ability that can save lives. We are not there yet, but this work takes us one step closer,” said Varghese, who is a faculty member of the UC San Diego Institute of Engineering in Medicine.

In addition, the work will be useful to researchers involved in basic stem cell research as well as stem-cell-based clinical trials. For example, in current clinical trials involving human stem cells, the cells are often conditioned in an artificial environment so that when they are implanted into humans, they are more apt to differentiate into the right kinds of cells. Additional control over the cues the cells receive during this conditioning phase could be critical to future regenerative therapy successes.

Crucial Undergraduate Input

“A significant portion of the credit goes to Han Lim, who did this work as an undergraduate bioengineering student. A lot of ideas bounced back and forth between he and I,” said Varghese. “Han also sought out collaboration with NanoEngineering professor Gaurav Arya in order to incorporate mathematical modeling into the project. Han and the other undergraduates on this project were very active. They were coming to me and saying, “ËœWhy don’t we do this, why don’t we do that? Let us do this, let us do that!’,” said Varghese.

“I feel really excited and privileged to be given this opportunity to work independently with my colleagues, all of them being undergraduates except Professors Arya and Varghese. I must say initially it was very daunting, but I received a lot of help along the way,” said Han Lim, the first author on the paper who performed this work as a bioengineering undergraduate, including a 2008 stint at a Calit2 Summer Undergraduate Research Scholar. (Video: watch Han Lim’s poster presentation on SciVEE.)

“I’d like to thank all my collaborators for their contributions, and especially Dr. Varghese for believing in our potential. With this research, I hope that somewhere in the future we will be able to manipulate chemical, mechanical, and electrical cues such that one can create better biomimicking materials for applications in tissue engineering. As for myself, it would be great if I can further my studies in this field by looking at other ways of studying and manipulating cell behavior. After my studies, I aim to pursue a career in academia and continue to work for the advancement of the field as well as improve the quality of medicine and life,” said Lim.

Varghese’s bioengineering research projects span the continuum from basic research to translational work aimed at bridging the bench-to-bed divide. The lab, however, is united by one overarching goal: to treat dysfunctional tissues or organs using stem cells and healthy tissues derived from stem cells.

“I strongly believe that if we don’t fundamentally understand the science, then the translational work cannot happen. We need to know what is happening in nature before we can successfully mimic it,” said Varghese.

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Preservative-Free Nasal Spray Appears Safe, Remains Sterile

In a small, short-term study, a preservative-free, acidified nasal spray appears safe and well tolerated and maintained its sterility in an applicator used multiple times, according to a report in the November issue of Archives of Otolaryngology”“Head & Neck Surgery, one of the JAMA/Archives journals.

“The health of a topical nasal spray user relies on the prevention of contamination of the solution,” the authors write as background information in the article. “Pharmaceutical manufacturers add various preservatives to destroy or inhibit the growth of micro-organisms that may be introduced into the solution after the opening of its container.” However, some of these preservatives have been association with injury to the mucus membrane of the nose and sinuses, changes to the cells in the nasal lining, immobility of nasal hairs or cilia, damage to DNA and other adverse effects.

Making saline nasal spray more acidic is an alternative way of maintaining sterility without chemical preservatives. William R. Ryan, M.D., now of the University of California, San Francisco, and Peter H. Hwang, M.D., of Stanford University School of Medicine, Stanford, Calif., evaluated a saline solution formula acidified by hydrochloric acid. Twenty volunteers used the preservative-free nasal spray and a saline spray containing preservatives for one week each in random order, separated by a one-week washout period. At the beginning of the study and after the week of using each solution, participants reported their symptoms and underwent examination of their nasal passages with an endoscope. A sample from each nasal spray bottle was cultured for microorganism growth.

No differences were observed in symptoms or in endoscopy findings after using the preservative-free vs. preservative-containing spray. In addition, microorganism growth was not detected in any samples from either solution.

“Of those analyzed, we believe that the most important symptoms for determining the safety and tolerance of the preservative-free acidified solution nasal spray are nasal burning, smell disturbance, taste disturbance, nasal bleeding, purulent rhinorrhea [runny nose with pus], sore throat, need to blow nose, sneezing, runny nose, postnasal discharge, thick nasal discharge, ear fullness, ear pain and facial pain or pressure,” the authors write. “There were no discernible differences in these symptoms between the two nasal sprays used.” There were also no differences in discharge, swelling, redness and the growth of polyps in the nasal passages.

“In conclusion, the preservative-free acidified solution nasal spray used in this study seems to be safe, well tolerated and effective at maintaining a sterile solution in a multidose applicator among a small sample of users over a short period,” the authors write. “A larger series with longer follow-up is planned. Further studies are also necessary to explore use of a preservative-free acidified solution as a medium for drug delivery.”

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Drumlin Field Discovery Gives Answers About Glaciation And Climate

The landform known as a drumlin, created when the ice advanced during the Ice Age, can also be produced by today’s glaciers. This discovery, made by researchers from the University of Gothenburg, Sweden, has just been published in the scientific journal Geology.

Drumlins generally consist of an accumulation of glacial debris ““ till ““ and are found in areas that were covered by ice sheet. As the ice advanced, it moved rocks, gravel and sand and created tear-shaped raised ridges running parallel with the movement of the ice.

“Until now, scientists have been divided on how drumlins were created,” says Mark Johnson from the Department of Earth Sciences at the University of Gothenburg. “Because they are formed under the ice, it’s not an observable process. Drumlins are common almost everywhere the Ice Age ice sheets existed, but they’re almost unknown with modern-day glaciers. Now, though, we’ve found a new drumlin field by the Múlajökull glacier on Iceland. It’s quite unique.”

The melting of glaciers reveals drumlins

The melting of glaciers as a result of climate change has helped the researchers to study this geological phenomenon. The drumlin discovery on Iceland has presented unique opportunities to study their structure.

“One of the drumlins we found was sliced through by erosion. This gave us an opportunity to study it layer by layer, and it was clear that it had been built up only recently. In other words, the glacier has not just retreated to reveal old drumlins, but is continuing to create new ones.”

There are currently multiple theories about the origins of drumlins. The Gothenburg researchers’ discovery shows that they can form within two kilometers of the edge of the ice.

“A surging glacier can move 100 meters a day, as opposed to the more normal 100 meters a year. If we can link drumlins to fast-moving glaciers, this would mean that the ice sheet advanced much more quickly than scientists currently believe.”

Can affect climate research

The link between drumlins and rapid ice movements is important for climate research. When modeling climate change, we need to know how high and how cold a glacier was in order to understand the last Ice Age. A glacier that moves quickly will not be as thick. This discovery could therefore affect how scientists approach climate modeling.

Solving the riddle of the drumlin is a longstanding dream for Mark Johnson:

“We discovered the drumlin field while flying in towards the edge of the glacier to do a completely different study. It was the most exciting thing I’ve been involved in during my research. All geologists know about drumlins, and when I began to study geology in Wisconsin in the 1980s, many people would come there to study the drumlins in the area. Coming up with a theory for how they formed was a big question even then.”

The discovery of the new drumlin field was made by Mark Johnson from the Department of Earth Sciences at the University of Gothenburg in collaboration with researchers from Iceland, Norway and the UK.

Image 1: This is the edge of the Múlajökull glacier on Iceland. The ridges between the lakes are drumlins. Credit: ÃÂvar ×rn Benediktsson

Image 2: This is a drumlin by the Múlajökull glacier on Iceland. The ravines cutting into the drumlin have given researchers an opportunity to study its structure. Credit: Mark Johnson

Image 3: This is a drumlin in Wisconsin, USA. Credit: Donna Harris

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Important Brain Area Organized By Color, Orientation

A brain area known to play a critical role in vision is divided into compartments that respond separately to different colors and orientations, Vanderbilt University researchers have discovered. The findings have important implications for furthering our understanding of perception and attention.

The research was published Nov. 14, 2010, in Nature Neuroscience.

“In vision, objects are defined by both their shape and their surface properties, such as color and brightness. For example, to identify a red apple, your visual system must process both the shape of the apple and its color,” Anna Roe, professor of psychology and co-author of the new research, said. “Our study showed that in V4, which is a brain area that plays a role in visual object recognition, there is significant segregation of color/brightness and shape processing regions.

“We also found that processing regions come in different flavors,” she continued. “There are

color processing domains, for example, for purple, green and yellow. Shape processing domains come with preference for different orientations, such as horizontal or vertical. This is a functional segregation that has never been seen before in V4.”

The researchers made their discovery by examining V4 in awake macaque monkeys. V4 was already known to play a key role in shape and color perception, but uncertainty about its organization has led to debates among researchers about the overall role it plays in vision.

“One reason this segregation is important relates to visual attention. For example, in your multicolored world, you can easily pick out a purple object if you’re looking for it. How does your brain direct your attention to only purple? The fact that there are purple domains in V4 that are distinct from green or yellow domains gives us a handle on the specificity with which we can focus our attention,” Roe said. “These domain-based ideas about how attention is implemented in the brain are exciting directions that we are currently investigating.”

The researchers speculate the compartmentalization may reflect groups of neurons that are processing more complex aspects of color and form, such as integrating different contours that are the same color, to achieve overall shape perception.

Though V4 is segregated, the different areas do work together to process information.

“Functional segregation does not mean that shape and surface information do not interact.  What it means is that there are distinct circuits for color vs. shape,” Roe said.

The researchers obtained their data by using novel imaging methods that will open up new ways of studying cognitive functions such as attention and memory and new ways to study behavior. The team is the first to be able to obtain images that allow the viewer to see the different cortical organizations in awake, behaving monkeys.

Hisashi Tanigawa, research associate in the Department of Psychology, was the paper’s lead author. Haidong D. Lu, now a researcher at the Institute of Neuroscience, Chinese Academy of Science, was a co-author.

Grants from the National Institutes of Health, Vanderbilt Vision Research Center and Vanderbilt University Center for Integrative and Cognitive Neuroscience supported the research.

Image 2: Different areas of the brain area V4 respond specifically to color and orientation. In this image of V4, the magenta-colored areas are those that responded most to color and luminance, while the green areas were most sensitive to orientation. (Image courtesy of Anna Roe)

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Lead Discovered In Reusable Shopping Bags

A New York Senator is calling for a probe into environmentally friendly reusable grocery bags following reports that they may contain dangerous levels of lead.

Senator Charles Schumer of New York announced on Monday that he has or will contact the Food and Drug Administration (FDA), the Consumer Product Safety Commission (CPSC), and the Environmental Protection Agency (EPA) after an investigation by the Tampa Tribune, in which lead was discovered in bags purchased at Winn-Dixie, Publix, Sweetbay, Walmart and Target.

“Federal agencies need to put a ban in place for reusable bags that have lead in them,” Schumer said in a statement, according to Stephanie Armour of USA Today. Armour also notes that the Democratic Senator sent a letter to the FDA, asking them to open an investigation into the issue and saying that “any situation where lead bags are coming into contact with the food being purchased by Americans needs to be immediately investigated and resolved.”

According to a CBS News reports, Schumer claims that many of the reusable grocery bags found in the U.S. are actually made in China, the source of several other products that have faced recalls or probes over their lead content in recent months. The reusable bags are made available by retailers in an attempt to cut down on the use of plastic bags, but lead-tainted ones could contaminate the food contained within them or seep into landfills, causing environmental harm.

Lead is a toxic substance that has been linked to learning disabilities in children and fertility problems in adults, according to the Associated Press (AP).

As part of the original investigation, Richard Mullins of the Tampa Tribune wrote that the newspaper purchased two-dozen reusable bags from the largest grocers in the area. They then put the bags through two sets of tests at Tampa-based Thornton Laboratories–a group “which regularly tests food and chemicals for industrial clients, and has tested children’s jewelry for the Tribune,” according to Mullins.

While Mullins noted that the packaging industry is attempting to limit lead levels of 100 parts per million, Florida currently has no official policy regulating such content. Bags from Winn-Dixie showed lead levels of 121 and 117 in each of the two tests respectively, while Publix bags yielded results of 87 and 194 in separate tests.

“The bags tested by the Tribune with the highest lead levels tended to have the most elaborate designs or illustrations that covered the entire surface,” said Mullins. “By contrast, a nylon bag sold by Target with almost no illustrations had almost undetectable levels of lead. Also, the simplest bags from Sweetbay, Walmart and Publix contained little lead.”

In an email sent to the AP late last week, Winn-Dixie spokesperson Robin Miller said that she was confident that the bags were safe and that the supermarket chain would “continue to work closely with our suppliers to make certain that we are in compliance with industry standards.” Miller also said any consumer who was concerned over the bags’ lead content could return them for a refund.

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Fiberglass

Fiberglass consists of numerous extremely fine fibers of glass. Although experimented with throughout history actual glass fibers were not mass produced until the invention of finer machine tooling.

A dress with glass fibers was first worn in 1893 by stage actress Georgia Cayvan. Russell Games Slayter invented, in 1938, what is commonly known as fiberglass today. It is commonly used for insulation. Carbon fiber is also a somewhat similar but more expensive technology used in place of fiberglass when high strength and low weight is necessary.

To form glass fibers thin strands of silica-based glass is extruded into many fibers with small diameters that are suitable for textile processing. The process of creating these fibers has been known for a while; however, the use of the fibers for textile application is more recent. In 1936 the first commercial production of fiberglass took place. After Owens-Illinois Glass Company and Corning Glass Works joined they introduced continuous filament glass fibers. Owens-Corning is still the major fiberglass producer in the market today.
E-glass is most commonly used although A-glass, E-CR-glass, C-glass, D-glass, R-glass, and S-glass are also used. Silica is the basis for textile-grade glass fibers. Its pure form exists as a polymer and has no true melting point. Since the vitreous and crystalline states of silica have similar energy levels on a molecular basis it is implied that the glassy form is extremely stable. It has to be heated to temperatures above 2,190 °F for long periods of time.

Pure silica is viable glass and glass fiber but has to be worked with at very high temperatures. In order to lower the necessary work temperature other materials are introduced. Soda lime glass, A-glass, was the first type of glass used for fiber. E-glass, which is alkali free, was the first glass formulation used for continuous filament formation. The E-glass makes up most of the fiberglass production in the world. E is used since the fibers were originally used for electrical applications. Chloride ions will also attack and dissolve E-glass surfaces. S-glass is used when tensile strength is most important. C-glass is resistant to attack from chemicals along with T-glass which is the North American variant of C-glass. A-glass refers to cullet glass made into fiber.

The fibers are useful due to their high ratio of surface are to weight and by being able to trap air within them making blocks of glass fiber good thermal insulation. The strength is tested and reported right after manufacturing. The more the surface is scratched the less the resulting tenacity. Humidity is also an important factor in tensile strength because the moisture can worsen cracks and surface defects which lessen tenacity.

Glass is capable of undergoing more elongation before it breaks than carbon fiber. For manufacturing success one of the important keys is the viscosity of molten glass. This viscosity should be relatively low during drawing because if it is too high the fiber will break and if it is too low the glass will form droplets rather than drawing out in the fiber.

Fiberglass gained in popularity when it was found that asbestos causes cancer, however, recent research shows that the composition of this material causes similar toxicity as asbestos. These stats are debatable. The North American Insulation Manufacturers Association believes that since fiberglass is man-made it differs from naturally occurring asbestos. The NAIMA claims asbestos to be more dangerous due to its crystalline structure. Since fiberglass has synthetic vitreous fibers they don’t split longitudinally to form thinner fibers like asbestos. They also have less bio-persistence in biological tissues than asbestos fibers.

Fiberglass can be used in mats, thermal insulation, electrical insulation, sound insulation, reinforcement of various materials, tent poles, sound absorption, automobile bodies, hockey sticks, surfboards, boat hulls, and paper honeycomb. It can be used in medical purposes in casts.

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Tetris Could Help With Flashbacks

Researchers have found that the video game Tetris may reduce flashbacks or traumatic events in a way that other kinds of games cannot.

Tetris involves moving and rotating shapes falling down a playing field with the goal of creating horizontal lines of blocks without gaps.

Scientists at Oxford University in England found that playing Tetris after traumatic events could reduce flashbacks in healthy volunteers.  The hope of this research is to reduce the painful memories linked with post-traumatic stress disorder (PTSD).

The researchers compared the game with Pub Quiz Machine 2008 to see if this effect was found only in Tetris or with other games as well.  The investigators began showing volunteers a gruesome film with traumatic images of injury and death, like fatal traffic accidents and graphic scenes of human surgery.

Twenty volunteers played Tetris for 10 minutes, while 20 played Pub Quiz and 20 others did nothing.  The researchers found that Tetris significantly reduced flashbacks while Pub Quiz significantly increased them. 

“Our latest findings suggest Tetris is still effective as long as it is played within a four-hour window after viewing a stressful film,” said researcher Emily Holmes, a research clinical psychologist at Oxford University. “Whilst playing Tetris can reduce flashback-type memories without wiping out the ability to make sense of the event, we have shown that not all computer games have this beneficial effect “” some may even have a detrimental effect on how people deal with traumatic memories.”

Past research has found that there is a timeframe of up to six hours after a trauma in which one can interfere with the way traumatic memories are formed in the mind.  Certain tasks can compete during this window of opportunity with the same mental channels needed to form those memories.

The Oxford team said that Tetris achieves its beneficial effects regarding flashbacks by competing with traumatic details on the sensory channel.  However, Pub Quiz might compete with the conceptual channel, reinforcing sensory details of traumatic events.

“These laboratory experiments can help us understand how unwanted flashback memories may be formed,” Holmes told LiveScience. “This can help us better understand this fundamental aspect of human memory. It may also lead us to think about new ways to develop preventative treatments after trauma.”

However, Holmes said: “Whist this work is still experimental, and any potential treatment is a long way off, we are beginning to understand how intrusive memories/flashbacks are formed after trauma, and how we can use science to explore new preventative treatments.”

The scientists reported their findings in the journal PLoS ONE on November 10.

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Amazon To Hire Thousands Of Seasonal Workers

Amazon.com on Friday said it will be hiring more than 15,000 people to fill temporary jobs at shipping centers around the country this holiday season to help with the upcoming busy shopping months, more than it hired a year ago.

The online retailer said it will hire more than 5,000 people at its Phoenix and Goodyear, Arizona centers, and 4,000 in Pennsylvania at locations including Allentown, Hazleton and Lewisberry.

It will also hire 2,500 people in Whitestown and Plainfield, Indiana and more than 2,000 each in Hebron, Kentucky and Fernley, Nevada.

Amazon said it is hiring more people this year than last, but did not say exactly how many more.

Many retailers are also hiring more temporary workers for the holiday season, including Kohl’s Corp., Macy’s Inc., Toys R Us, Pier 1 Imports Inc. and American Eagle Outfitters Inc.

Upwards of 650,000 jobs will be filled at retailers around the country this season, according to an updated forecast from national outsourcing firm Challenger, Gray and Christmas.

That is a big increase from the 500,000 added last year, but still far below the 720,000 added in 2007 when the recession began.

Online sales account for about 10 percent of US holiday sales, but are growing. Research firm comScore said it expects the online retail sector to grow 7 to 9 percent compared with a year ago, when online holiday sales were 4 percent higher than the year before.

Amazon.com shares fell $4.55 or 2.7 percent to $165.82 on Friday.

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