Sexually harassed women leave workplace

Women who encounter workplace sexual harassment tend to leave the organization, researchers in Israel said.

Research student Chana Levi and Professor Eran Vigoda-Gadot of the University of Haifa surveyed 192 women who work in the public sector in Israel. The purpose of the study was to observe whether women who had been sexually harassed would tend to leave their place of work, develop behaviors of work neglect or attempt to change the situation by means of taking particular action.

The study found that the level of reported sexual harassment was rather low.

The workers were asked to rank harassment experiences on a scale of 1-5 with 1 indicating no sexual harassment at all and 5 indicating constant harassment. Sexual harassment was defined as offensive sexually suggestive comments, repeated harassment intended to lead to sexual relations and actual sexual coercion.

The reported level of sexual harassment was 1.38, but one-third of the women reported having experienced gender harassment at medium or high frequency. Almost 90 percent of the women never experienced repeated attempts at sexual relations or seldom experienced it and 95.37 percent of the workers never or seldom experienced sexual blackmail.

The second stage of the study examined behavioral patterns of women who had experienced sexual harassment. It revealed that harassed women tend to leave their jobs.

Honey Badger

The Honey Badger (Mellivora capensis), also known as the Ratel, is a member of the Mustelidae family. It is found throughout most of Africa and western and southern Asian regions of
Baluchistan (eastern Iran), southern Iraq, Pakistan and Rajasthan (western India). Its natural habitat is arid grasslands and savannahs. It is the only species in genus Mellivora. It has been named the most fearless animal for several years in the Guinness Book of World Records.

The Honey Badgers is similar in size and build to the European Badger (Meles meles). It is heavily built, with a broad head, small eyes, and a blunt snout. Its total body length is 30 to 52 inches. The tail alone is up to 12 inches long. It stands 9 to 12 inches high at the shoulder. Adults vary in weight from 12 to 30 pounds. The sizes between the male and female is considerable. Males can weigh up to two times as much as the female. Females have a maximum weight of 22 pounds.

The Honey Badger is a fierce carnivore with a keen sense of smell. It is popularly known for its snake killing abilities. Adult honey badgers can devour an entire 5 foot snake in as little as 15 minutes. It also has a huge appetite for beehives, hence the name “Ëœhoney’ badger. There have been cases of honey badgers being stung to death within hives they were trying to eat. Commercial honey producers do not take kindly to this destruction and will often shoot, trap, or poison honey badgers they suspect have damaged their hives. Some sources indicate that the honeyguide bird has a habit of leading honey badgers to bees’ nests. When the honey badger breaks into the nest, the bird will take its share too. Many sources disregard this statement and believe that honeyguides only guide humans to the hives.

The Honey Badger is among the fiercest hunters in its range. Its prey includes earthworms, termites, scorpions, porcupines, hares, tortoises, crocodiles (up to 40 inches), and snakes (including venomous snakes). Its ferocious reputation extends to attacks on animals much larger than itself. There is a case of a honey badger being bitten by a puff adder as it is eating it, and becomes paralyzed for about 5 minutes. Once the paralysis wears off, the badger continues with its meal and resumes it journey. The badger may even steal a snake’s kill and eats it for itself before continuing to hunt down the snake.

The Honey Badger will also dig into burrows of small rodents and flush them out for a small meal. The badger’s large front claws enable to dig into burrows effectively and most opportunities for a meal are successful. The one problem with this is that once it flushes out the meal, other predators and birds of prey may be in the area waiting to steal the kill from the Honey Badger. It is also very intelligent and is one of the few animals capable of using tools. In a 1997 documentary (Land of the Tiger), a honey badger rolled a log and stood on it to reach a kingfisher fledgling stuck up in the roots coming down from the ceiling in an underground cave.

The adult Honey Badger has few predators. Its ferocity and thick, loose skin makes it difficult for larger animals to grip or suffocate them. Leopards, lions, and large pythons are the only predators that rarely will attack a Honey Badger. An old, weak Honey Badger is more likely to fall prey to an attack, however it will defend itself vigorously. In one case, an old female honey badger that was blind in one eye and nearly toothless was attacked by a leopard. It took the leopard about one hour to kill the honey badger.

Courtship of the Honey Badger is very energetic. Once a female comes into heat, it will deliberate for days before accepting a male to mate with and the honey badgers will remain in the burrow for 3 to 4 days of mating. The female will give birth to a cub 2 months later. The cub relies on the mother for food and shelter as they regularly move and she digs new burrows. Cubs can make adults vulnerable while they are hunting, so they are often left behind at the burrow. This is dangerous for the cub, which is vulnerable to predators, including other honey badgers that will drag the cub out of the burrow and eat it. This cannibalistic practice is why only half of Honey Badgers make it to adulthood. As a cub grows, it is taught by the mother how to survive. The Honey Badger is not born with the vital skills it needs for survival. Once the cub is old enough to thrive on its own (about two months old), the mother will come back into heat and be ready to mate again.

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Study Compares Stress Levels In Soldiers

A U.S. researcher said on Sunday that soldiers who perform best under extreme stress have higher levels of chemicals that dampen the fear response, Reuters reported.

Many say the finding could lead to new drugs or training strategies to help others cope better with intense combat situations.

Deane Aikins of Yale University in New Haven, Connecticut said that certain individuals just don’t get as stressed as others.

“Their stress hormones are actually lower,” she told reporters at the American Association for the Advancement of Science meeting in Chicago.

The research at Yale University involved the study of stress hormone levels in soldiers undergoing survival training.

Aikins and colleagues observe soldiers under a series of war-simulated stress tests including mock prisoner of war experiences.

After blood tests, those soldiers who fared best under extreme stress had lower levels of the stress hormone cortisol and higher levels of neuropeptide y, a chemical that dampens the body’s stress response.

“All of the recovery hormone systems, all of the systems that turn it down, really kick in for these resilient individuals,” Aikins said.

The researchers now hope to find out how to help soldiers that aren’t as cool under stress.

Aikins said his team is now looking into whether giving other soldiers a dose of this stress-dampening neuropeptide might help people fare better in combat situations.

Mental training exercises such as meditation also might help improve the performance of soldiers under stress, researchers added.

Image Courtesy US Army

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Plaster Is The Best Option For Sprains

British researchers have found that people with a sprained ankle recover faster if they are given a plaster cast, BBC News reported.

A 10-day below-knee cast is more effective than standard treatment with a tubular bandage, according to a study of 600 patients.

For years, the general medical opinion was that the best thing for a sprained ankle is to keep it moving.

In the UK, sprained ankles account for some 3-5 percent of all emergency room visits and they vary from minor stretching of the ligament to complete tears.

Doctors typically treat such sprains with ice, elevation, tubular compression bandage and advice to exercise.

However, tubular bandaging was consistently found to be the worst treatment, researchers said.

The researchers noted that in patients with severe ankle sprains, a 10-day below-knee cast was associated with a speedier recovery in terms of ankle function, pain, symptoms and activity after three months.

The Aircast brace, which limits movement of the ankle, was found to be the second best method of treatment.

The study also showed that the Bledsoe boot””another type of brace designed to restrict movement of the ankle while allowing users to walk””was no more effective than a tubular bandage. The study further recommended that neither treatment be used for ankle sprains.

A plaster cast is also one of the more modestly priced procedures for these types of injuries.

“The finding that immobilization is the best strategy is contrary to popular clinical opinion,” said Professor Sallie Lamb, an expert in rehabilitation at the University of Warwick.

“Tubular compression bandage, which is currently the most commonly used of all the supports investigated, was, consistently, the worst treatment.”

She said the speed with which people are able to get back to normal activities is an important finding.

“I think plaster should be given as standard management.”

John Heyworth, president of the College of Emergency Medicine, called the study “practice-changing, high quality research”.

Heyworth said, until this paper, the evidence suggested that early mobility provided a better outcome. “This provides some good evidence that immobilization can provide greater benefits.”

Doctors have tried to avoid immobilizing the ankle because of the risk of deep vein thrombosis, according to Dr. Martin Shalley, A&E consultant at Birmingham Heartlands Hospital.

“That has to be balanced and we can discuss the pros and cons with the patient and work out the best treatment program for them.”

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Silver nanoparticle ink is developed

U.S. scientists say they’ve developed a silver nanoparticle ink that can create flexible, stretchable and spanning microelectrodes.

University of Illinois Professor Jennifer Lewis and colleagues said such printed microelectrodes can withstand repeated bending and stretching with minimal change in their electrical properties.

Unlike inkjet or screen printing, our approach enables the microelectrodes to be printed out-of-plane, allowing them to directly cross pre-existing patterned features through the formation of spanning arches, Lewis said. Typically, insulating layers or bypass electrode arrays are required in conventional layouts.

When printed, the silver nanoparticles are not yet bonded together, the scientists said. The bonding process occurs when the printed structure is heated to 150 degrees Celsius or higher. During thermal annealing, the nanoparticles fuse into an interconnected structure and, since only modest processing temperatures are required, the printed features are compatible with flexible, organic substrates.

The research that included Bok Yeop Ahn, Eric Duoss and Professors Ralph Nuzzo and John Rogers, appears in the online journal Science Express.

Removing Wrinkles With RHAMM

Hollywood stars of a certain age take note: Research at Berkeley Lab suggests that a protein linked to the spread of several major human cancers may also hold great potential for the elimination of wrinkles and the rejuvenation of the skin. If this promise bears fruit, controlling concentrations of the RHAMM protein could one day replace surgical procedures or injections with neurotoxins that carry such unpleasant side-effects as muscle paralysis and loss of facial expressions.

RHAMM stands for Receptor for Hyaluronan Mediated Motility. Mina Bissell, a cell biologist with Berkeley Lab’s Life Sciences Division and a leading authority on breast cancer, was collaborating with Eva Turley, an oncology professor at the University of Western Ontario and leading authority on tissue polysaccharides, on a study of the role that RHAMM plays in regulating the signaling of adipocytes (fat cells) during the repairing of tissue wounds from injuries such as skin cuts, heart attacks and stroke. Earlier research by Turley, who discovered RHAMM, had shown that over-expression of this protein points to a poor patient outcome for such human cancers as breast, colon, rectal and stomach.

In the course of their collaborative study, Bissell and Turley, working with mice, discovered that blocking the expression of the RHAMM protein – either by deleting its gene, or through the introduction of a blocking reagent – can be used to selectively induce the generation of fat cells to replace those lost in the aging process. At the same time blocking RHAMM expression also reduces deposits of unhealthy visceral fat.

“This technique could be developed as a means of providing a non-surgical approach for normalizing skin appearance after reconstructive surgery, for wrinkle reduction, and for face lifts and figure enhancement,” said Bissell.

Said Turley, “Unlike neurotoxin agents, which have to be injected periodically, a localized injection of a RHAMM inhibitor should produce long-lasting skin volumizing effects and would not involve muscle paralysis, which means there would be no loss of expression if it were to be injected into the face.”

There are compounds now on the market that promote the production of adipocyte cells and result in increased subcutaneous fat, however, these adipocyte-promoting factors also increase the production of visceral fat. The mouse studies led by Bissell and Turley have shown that blocking RHAMM expression significantly increases subcutaneous fat while decreasing visceral fat. This suggests that blocking RHAMM should also have a beneficial effect on patients with obesity-related diseases, cardiovascular disease or diabetes. Another unique advantage of RHAMM is that its expression in normal adult human tissues is restricted.

“Therefore, anti-RHAMM agents should have low toxicity and according to preliminary animal studies, could be beneficial to patients with a tumor or inflammation-related disease,” said Turley.

Potential applications of RHAMM modulation in addition to wrinkle reduction include normalizing skin appearance after reconstructive or cosmetic surgery, e.g., grafted tissue on burn victims. It has also been shown to have a beneficial effect on tumors and inflammatory diseases in mice.

Lynn Yarris, Berkeley Lab

Image 1: As we get older, fat cells in the subcutaneous layer of the skin become smaller and fewer in number so that they are not longer able to “fill in” damage to the epidermal and dermal skin layers. The results are wrinkles and sagging.

Image 2: In these images of stained normal mouse wound tissue (left), and mouse tissue with RHAMM blocked, the green stain shows collagen, the white layers are fat, and the red stain highlights keratinocytes, hair follicles and muscle. The images show that the subcutaneous fat layers in the RHAMM blocked tissue are significantly thicker than those of the normal mouse wound tissue.

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Video Games Beneficial For Children

A new report by the European Parliament Committee on the Internal Market and Consumer Protection says that video games may be good for children, promoting cooperation and creativity.

The report, which found a number of benefits and no definitive link to aggressive behavior, counters the violent reputation of some titles, and may help reassure nervous parents of game addicts.

“Video games are in most cases not dangerous and can even contribute to the development of important skills,” Toine Manders, the Dutch liberal lawmaker who authored the report, told Reuters.

“(They stimulate) learning of facts and skills such as strategic reflection, creativity, cooperation and a sense of innovation,” said a news release about the findings.

Rather than issuing a call for new legislation banning certain games, the report instead urged EU states to collaborate in strengthening the current voluntary code known as “PEGI”, which rates games according to their content.

Last year, total revenues from the video gaming industry were more than seven billion euros ($9 billion), the report said.  In Britain, video games outsold music and other video products for the first time last year, according to a separate study.

However, the EU report said that not all games are appropriate for children, and noted that some books and movies are targeted solely to an older audience.  It also conceded that some games that contain violent content could “stimulate” aggressive behavior in certain situations.

The report emphasized parental involvement, and proposed the development of a “red button” to allow parental control of game content and the duration of play.  However, the report did not provide specific details about what form such a button might take.

The report questioned prevailing wisdom that games were targeted mainly towards children, citing data that showed the European video game player is 33 years of age.

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How to avoid fish oil burps

A U.S. newsletter advises how to take those very healthy fish oil supplements, but avoid that fishy aftertaste.

People who want the benefits of omega-3 fatty acids but don’t want to eat a lot of fish often turn to supplements. The Mayo Clinic Health Letter advises putting capsules in the freezer before swallowing to avoid the fishy burp.

Swallow the capsule frozen, the newsletter said. This slows the breakdown of fish oil in the stomach, often reducing fishy burps. The fish oil is still digested effectively.

Other fish burp avoidance techniques include:

— Trying an odorless supplement. This type of coated capsule passes through the stomach and dissolves in the intestines.

— Switching brands. A different brand may taste less fishy.

— Paying more. Some manufacturers make a pure omega-3 fatty acids product that doesn’t taste fishy, although it is likely to cost more than standard products.

In the long run, the occasional fishy burp may be a small disadvantage compared to the mega health benefits of omega-3 fatty acids.

The Mayo newsletter said fish oil supplements often are prescribed for heart attack survivors. The supplements can help prevent future heart problems. They also are prescribed for people with high triglycerides, a type of fat in the blood.

Cotton Candy used To Generate Network Of Blood Vessels

Scientists are turning to cotton candy as a novel tool to help grow replacement tissues for people. It seems the long-time favorite treat may provide an ideal way to generate a network of blood vessels within lab-grown skin, bone, muscle or fat for breast reconstruction, researchers say.

Dr. Jason Spector of New York-Presbyterian Hospital/Weill Cornell Medical Center in New York and Leon Bellan of Cornell University conducted the research on the new technique. 

It works by first pouring a thick liquid chemical over the cotton candy, and waiting for the liquid to solidify into a chunk. The chunk is then put in to warm water to dissolve the cotton candy, leaving small channels where the strands of cotton candy used to be.  Eventually, what is left is a piece of material containing a network of fine channels.

These channels are then lined with cells to create artificial blood vessels.  The solid chunk can be seeded with immature cells of the type of tissue scientists wish to make.

Since the block is biodegradable, as it disappears it is slowly replaced by growing tissue. Ultimately what remains is a piece of tissue permeated with tiny blood vessels.

The researchers have so far made these blocks of material with rat blood running through the channels.  While they may eventually change to something other than cotton candy as the research progresses, Bellan hopes to keep using the inexpensive candy as long as possible.

Spector, who keeps a jar of jelly beans on his desk, told the AP he enjoys cotton candy and that with the current research, “it’s taken on a whole new meaning.”

But Bellan sees things differently.  

“I actually hate cotton candy,” he told the AP.

“It’s disgusting. I won’t eat it.”

The research was published online this week in the journal Soft Matter.

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Obesity In The Military On The Rise

The obesity rate among US troops has more than doubled since the start of the Iraq war in 2003, according to a new Pentagon report.

“In the past decade among active military members in general, the percent of military members who experienced medical encounters for overweight/obesity has steadily increased; and since 2003, rates of increase have generally accelerated,” said the report published in January’s edition of the Defense Department’s Medical Surveillance Monthly Report.

This result reflects a national trend of increasing obesity rates among Americans, however it also indicates the heightened stress of continuing combat deployments, the study said.

“Stress and return from deployment were the most frequently cited reasons for recent weight gain,” the report said.

In 1998, 25,652, or 1.6 percent of the entire armed forces were diagnosed overweight. In 2003, that figure increased to 34,333 – 2.1 percent, and has since risen to 68,786 – 4.4 percent of the total.

Additionally, the Army reports problems of obesity among recruits. One in five Americans between ages 18 to 34 is obese, the study says.

“Overweight/obesity is a significant military medical concern because it is associated with decreased military operational effectiveness.”

Last week, Army officials voiced concerns about the increasing rate of suicide among its soldiers in 2009, following a year that saw record US military suicide rates.

Confirmed and unconfirmed combined would amount to 24 suicide deaths among Army soldiers in January alone ““ six times the rate in January 2008. Furthermore, Pentagon data shows that there were 16 US combat deaths in Afghanistan and Iraq in January, making the number of suicide deaths one third larger than those occurring in combat.

The Army’s confirmed rate of suicides in 2008 was 20.2 per 100,000 soldiers. The nation’s suicide rate was 19.5 per 100,000 people in 2005, the most recent figure available, Army officials said last month.

Suicides for Marines were also up in 2008. There were 41 in 2008, up from 33 in 2007 and 25 in 2006, according to a Marines report.

“When people are apart you have infidelity, financial problems, substance abuse and child behavioral problems,” said Col. Kathy Platoni, chief clinical psychologist for the Army Reserve and National Guard. “The more deployments, the more it is exacerbated.”

The Pentagon also notes a rise in divorce rates among soldiers and Marines and increased use of prescription drugs in the Army.

Image Courtesy US Army

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Research Highlights Potential For Improved Solar Cells

Certain nanocrystals shown to generate more than one electron

A team of Los Alamos researchers led by Victor Klimov has shown that carrier multiplication””when a photon creates multiple electrons””is a real phenomenon in tiny semiconductor crystals and not a false observation born of extraneous effects that mimic carrier multiplication. The research, explained in a recent issue of Accounts of Chemical Research, shows the possibility of solar cells that create more than one unit of energy per photon.

Questions about the ability to increase the energy output of solar cells have prompted Los Alamos National Laboratory researchers to reassess carrier multiplication in extremely small semiconductor particles.

When a conventional solar cell absorbs a photon of light, it frees an electron to generate an electrical current. Energy in excess of the amount needed to promote an electron into a conducting state is lost as heat to atomic vibrations (phonons) in the material lattice. Through carrier multiplication, excess energy can be transferred to another electron instead of the material lattice, freeing it to generate electrical current””thereby yielding a more efficient solar cell.

Klimov and colleagues have shown that nanocrystals of certain semiconductor materials can generate more than one electron after absorbing a photon. This is partly due to strengthened interactions between electrons squeezed together within the confines of the nanoscale particles.

In 2004, Los Alamos researchers Richard Schaller and Klimov reported the first observations of strong carrier multiplication in nanosized crystals of lead selenide resulting in up to two electron-hole pairs per absorbed photon. A year later, Arthur Nozik and coworkers at the National Renewable Energy Laboratory reproduced these results. Eventually, spectroscopic signatures of carrier multiplication were observed in nanocrystals of various compositions, including silicon.

Recently, the claims in carrier multiplication research have become contentious. Specifically, some recent studies described low or negligible carrier multiplication efficiencies, which seemed to run contrary to earlier findings. To sort out these discrepancies, Los Alamos researchers analyzed factors that could have led to a spread in the reported carrier multiplication results. These factors included variations between samples, differences in detection techniques, and effects mimicking the signatures of carrier multiplication in spectroscopic measurements.

To analyze how a particular detection technique might affect an outcome, John McGuire, a postdoctoral researcher on Klimov’s team, investigated carrier multiplication using two different spectroscopic techniques””transient absorption and time-resolved photoluminescence. The results obtained by these two methods were in remarkable agreement, indicating that the use of different detection techniques is unlikely to explain discrepancies highlighted by other researchers. Further, although these measurements revealed some sample-to-sample variation in carrier multiplication yields, these variations were much smaller than the spread in reported data.

After ruling out these two potential causes of discrepancies, the researchers focused on effects that could mimic carrier multiplication. One such effect is photoionization of nanocrystals.

“When a nanocrystal absorbs a high-energy photon, an electron can acquire enough energy to escape the material,” Klimov explained. “This leaves behind a charged nanocrystal, which contains a positive ‘hole.’ Photogeneration of another electron by a second photon results in a two-hole, one-electron state, reminiscent of one produced by carrier multiplication, which can lead to false positives,” he said.

To evaluate the influence of photoionization, the Los Alamos researchers conducted back-to-back studies of static and stirred solutions of nanocrystals. Stirring removes charged nanocrystals from the measured region of the sample. Therefore, when crystals are subjected to light, the stirring eliminates the possibility that charged nanocrystals will absorb a second photon. While stirring of some samples did not affect the results of the measurements, other samples showed a significant difference in the apparent carrier multiplication yields measured under static and stirred conditions. Since most previous studies were performed on static samples, these results suggest that discrepancies noted by other researchers arise at least in part from uncontrolled photoionization, which stirring seeks to eliminate.

The Los Alamos researchers re-evaluated carrier multiplication efficiencies when photoionization was suppressed. The results are encouraging.

While the newly measured electron yields are lower than previously reported, the efficiency of carrier multiplication is still greater than in bulk solids. Specifically, both the energetic onset and the energy required to generate an extra electron in nanocrystals are about half of those in bulk solids.

These results indicate significant promise for nanosized crystals as efficient harvesters of solar radiation.

“Researchers still have a lot of work to do,” Klimov cautioned. “One important challenge is to figure out how to design a material in which the energetic cost to create an extra electron can approach the limit defined by a semiconductor band gap. Such a material could raise the fundamental power conversion limit of a solar cell from 31 percent to above 40 percent.”

The Los Alamos nanocrystal team’s research is funded by the U.S. Department of Energy Office of Basic Energy Sciences and Los Alamos’ Laboratory-Directed Research and Development (LDRD) program.

By James E. Rickman, Los Alamos National Laboratory

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As Temps Rise, Plants Move Upwards

A UA-led research team has found that as the climate warms, plants are flowering at higher elevations in the Santa Catalina Mountains.

Plants are flowering at higher elevations in Arizona’s Santa Catalina Mountains as summer temperatures rise, according to new research from the University of Arizona in Tucson.

The flowering ranges of 93 plant species moved uphill during 1994 to 2003, compared to where the same species flowered the previous ten years. During the 20-year study period, summer temperatures in the region increased about 1.8 degree Fahrenheit (1 degree C.).

“For years, probably decades now, scientists have been trying to understand how species are going to respond to the anticipated global changes and global warming,” said Theresa Crimmins, research specialist for the UA’s Arid Lands Information Center and the network liaison for the USA National Phenology Network.

To better understand how plants respond to climate change, Crimmins and her husband, UA climatologist Michael Crimmins, teamed up with naturalist Dave Bertelsen. He’s been hiking the Finger Rock trail about one to two times a week since 1983 and recording what plants were in flower.

The 5-mile hike starts in desert scrub vegetation and climbs 4158 feet (1200 meters), ending in pine forest. Bertelsen has completed 1,206 round-trip hikes and recorded data along the trail for nearly 600 plant species, he said in an e-mail.

Lead author Theresa Crimmins said Bertelsen’s data shows that some species flowered farther upslope than before, others stopped flowering at lower elevations, and some species did both.

Because some plant species are moving and others staying put, she said the changes may divide plant communities, increase the growth of invasive species and even cause local extinctions by affecting the food sources of local insects and animals.

“I think we can be confident that things are going to continue to change and we don’t necessarily know the ripple effects of all these changes in flowering ranges,” Crimmins said.

Theresa Crimmins, Michael Crimmins, assistant professor and climate science extension specialist for the UA’s department of soil, water, and environmental science, and Bertelsen will publish their paper, “Flowering range changes across an elevation gradient in response to warming summer temperatures.”

The paper is published in the online Early View of the journal Global Change Biology. The U.S. National Park Service provided data management support for the project.

Many scientists have wanted to study the movement of flowering ranges, but lack the years of detailed data required for this research, Theresa Crimmins said.

At a meeting about monitoring plant species held by the U.S. Bureau of Land Management in 2005, Crimmins discussed his need for data to study the effect of climate change on ecosystems over time.

Bertelsen was at the meeting and told Crimmins about the extensive data he had collected during his many years hiking Finger Rock trail. Bertelsen had the sense some plants were flowering farther uphill and had observed many changes he attributed to drought.

Bertelsen had begun hiking the trail in 1981 and fell in love with the flora and fauna. He had just taken up macrophotography and took close-up pictures of all types of plants and animals while recording his observations in a journal.

“Somebody once said that I have this compulsion. I don’t feel driven at all, it’s drawn. If I miss a week, I miss it. I just feel that I’m really part of that canyon and it’s a part of what I am. It’s just good old human curiosity,” Bertelsen said. “There’s always something different. It’s just absolutely amazing.”

In 1983 he developed a checklist to document each species in bloom along each of five one-mile long trail segments. Thus, on a single day, if a particular plant was seen in bloom in three segments, there would be three different records. Bertelsen collected flowering data from 1984 to 2003.

To see whether the plants had shifted their flowering, the Crimminses compared Bertelsen’s location records from 1984 to 1993 for 363 plant species with his records from 1994 to 2003 for the same species.

The Crimminses used climate data from six National Weather Service Cooperative Observer Network stations surrounding the trail to see how the temperature varied during the 20-year study period.

The Crimminses’ collaboration with Bertelsen is a great example of how scientists and amateur naturalists can work together, Theresa Crimmins said. As part of its mission, the USA National Phenology Network encourages such collaborations to document events in the life cycles of plants and other organisms.

Theresa and Michael Crimmins plan to do additional analyses of the data to determine whether climate change is also causing flowers to bloom earlier in the year.

“The changes are happening fast enough now that more eyes on the ground are going to be much more useful as the human species tries to understand how these other systems, that we rely upon so dearly, are going to change,” Theresa Crimmins said.

“We can really start to think about what the true impacts of those changes are and how can we mitigate these impacts.”

By Megan Levardo, NASA Space Grant Intern, University of Arizona

Image 1: Miniature woolly star, known to scientists as Eriastrum diffusum, is one of the plants that has been blooming at higher elevations in Arizona’s Santa Catalina Mountains as the summer temperatures warm. (Credit: C. David Bertelsen)

Image 2: Dave Bertelsen hikes Finger Rock trail in the Santa Catalina Mountains. Tucson, Arizona can be seen in the valley below. Bertelsen has been hiking the trail and recording the locations of plants in bloom for more than 25 years. (Credit: Ben Wilder)

Image 3: Theresa Crimmins, a research specialist for the UA’s Arid Lands Information Center, is among those who have been studying the flowering ranges of various plant species.

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Blowing Your Nose May Be More Hazardous Than Helpful

Although it may come as second nature to blow your nose to alleviate stuffiness, some argue that it reverses the flow of mucus into the sinuses and slows down the drainage.

Dr. J Owen Hendley, and other pediatric infectious disease researchers at the University of Virginia, conducted CT scans and other measurements as subjects coughed, sneezed and blew their noses, according to the New York Times.  The subjects, in some cases, had an opaque dye dripped into their rear nasal cavities.

Coughing and sneezing generated little, if any, pressure in the nasal cavities.  However, nose blowing generated enormous pressure, equivalent to a person’s diastolic blood pressure reading, Hendley said.  This pressure propelled mucus into the sinuses every time.  Hendley also said that it was unclear whether this was harmful, but added that during sickness it could shoot viruses or bacteria into the sinuses, and possibly cause further infection.

Dr. Anil Kumar Lalwani, the chairman of the department of otolaryngology at the New York University Langone Medical Center, said the proper method is to blow one nostril at a time and to take decongestants.  This prevents a buildup of excess pressure.

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System Provides Real-Time Look At Human Muscle Movement

Dutch researchers have developed a digital imaging system they hope to use to shorten the rehabilitation period for people who have sustained an injury or suffered from a stroke.

Owned by Dutch firm Motek Medical, the system gives doctors and patients a real-time glimpse at the human body while highlighting muscle movement.

“Forces are invisible to the eye. HBM changes that and allows forces to become visible to the eye through color space changes in the muscle model representing the patient immersed in the system,” Motek explains on its Web site.

“Much like an X-ray system can show the bones in the body, HBM will be able to show the transference of forces in the body as they occur.”

“It’s like we’re stripping off the skin and helping the doctor to see more clearly than they have before,” said Michiel Westermann, chief executive of Motek.

The system uses infrared strobe lights and eight cameras to track muscle movement in patients while they wear reflective suits during exercise.

Dutch researchers said the system could help doctors analyze the conditions of their patients more effectively, which would also speed up rehabilitation time and get them back on their feet sooner.

Other applications of the system include: explorations of the muscle force interactions with spatial environments, better understanding of sensory inputs & motors in posture and motion, identification of “wasted” muscle force, and identification of muscle force related lower back pain complaints.

“Usually when patients are requested to activate a muscle, they will have a problem to understand which muscle, and the therapist will have a problem verifying the patient understood. With this they have immediate feedback,” said Westermann.

Westermann said the system is being tested in hospitals this year and should be ready for use by the beginning of 2010.

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Postpartum Psychosis Most Common In Older Women

A Swedish study on Tuesday showed that first-time mothers over the age of 35 are more than twice as likely as younger mothers to suffer postpartum psychosis that could involve a danger to the newborn child.

According to the AFP, the study, conducted by researchers at the Karolinska Institute in Stockholm, said the risk of developing psychosis during the first 90 days after childbirth increased with age.

The research was based on data gathered from all of the nearly 750,000 first-time mothers who gave birth in Sweden between 1983 and 2000. It showed that women over 35 giving birth for the first time were 2.4 times more likely to develop postpartum psychosis than those younger than 19.

The study also found that while some 80 percent of new mothers experience some kind of mental disturbance or light depression, only about one in 1,000 women suffer from actual psychosis in the first months of motherhood.

Postpartum psychosis is a serious mental disorder that can cause delusions, hallucinations, severe eating or sleeping disturbances, suicidal tendencies and can even be dangerous for newborn babies.

Doctors recommend women suffering from postpartum psychosis seek immediate medical attention, including the administration of anti-psychotic drugs and hospitalization.

Prior psychotic histories often accompany women who experience post partum psychosis, but nearly 50 percent of the cases appeared in women without prior psychotic hospitalization, according to the Karolinska research.

Meanwhile, the study suggested other factors like smoking and not living with the baby’s father had no impact on whether a woman developed postpartum psychosis.

The study, published in the Public Library of Science medical journal, said women suffering from diabetes and giving birth to babies with high birth weights reduced the risk of developing the disorder.

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Video Game Is Educational Complement

Playing and studying are not incompatible activities. A team of researchers from Madrid’s Complutense University (UCM) looks to integrating virtual graphic adventures into online education platforms and analyzes the educational and technological aspects that they should have to promote expansion.

“Video games in virtual educational environments are a complement to traditional teaching for the student”, Pablo Moreno-Ger, lead author of the study and member of the e-UCM educational technologies research group, led by Baltasar Fernández Manj³n in UCM’s Software Engineering and Artificial Intelligence Department, tells SINC.

According to research, the graphical adventure genre (e-Adventure) is the most flexible, covering the greatest number of subjects or areas of knowledge, and the one that, possibly, “works best in the area of education”. In these games, a wide variety of problems must be resolved through a story line designed to aid in the learning process.

The Spanish researchers believe that including video games in the online education platforms is the best way to achieve mass, economic distribution of this tool, the educational effectiveness of which is now rarely a topic of debate in the academic field.

However, widespread use of video games in these environments must still overcome certain educational and technical difficulties. According to the authors, an educational video game must be designed with three key elements in mind: the possibility for evaluation, adaptability and ease of integration.

According to this research, “teachers must be able to determine the progress of students playing at home, how they interact with the game, how they perform”. The problem is that it is not possible to completely track all of the actions taken by the students during the game, since that would hinder follow-up, nor limit the evaluation to one or a few actions. The idea, says the researcher, “is to identify the points that are relevant from an educational point of view”.

The technology must also enable the video game to be adapted to the specific educational needs of each student. “The machine needs to be taken advantage of so that the game is not static, rather it varies depending on the student’s profile”, explains Moreno-Ger, who also indicates that video games are “the ideal medium for adaptation; much richer than web pages”.

The final important element in designing educational video games is standardization; that is, “packaging the content so that it can move from one platform to another, launching it without problems”, the experts explain. This characteristic must also make the technical difficulties as transparent as possible, enabling the teacher to concentrate solely on preparing the content.

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AlphaGalileo

England’s High Blood Pressure Control Improving

Awareness, treatment and control of high blood pressure have increased significantly in England, according to a nationally representative health survey reported in Hypertension: Journal of the American Heart Association.

Researchers evaluated blood pressure management in 2006 compared to 2003, focusing on heart disease and its prevention. The key findings showed that among those treated, 53 percent of women and 52 percent of men achieved control of high blood pressure in 2006 compared to 44 percent of women and 48 percent of men in 2003.

“This is the first time in England that the majority of those on treatment are actually controlled,” said Neil R. Poulter, M.B.B.S., M.Sc., F.R.C.P., senior author of the study and professor and chairman of Preventive Cardiovascular Medicine at Imperial College London. “That’s a first and that’s good news.”

Analyzing 7,478 people (3,314 men and 4,164 women) ages 16 and older (average age 47), researchers found:

  • Awareness of high blood pressure reached 71 percent of women and 62 percent of men in 2006 compared to 64 percent of women and 60 percent of men in 2003.
  • Treatment was under way in 62 percent of women and 47 percent of men in 2006 compared to 52 percent of women and 43 percent of men in 2003.
  • Overall control was achieved in 32 percent of women and 24 percent of men in 2006 compared to 23 percent of women and 21 percent of men in 2003.

“This increase in the rate of awareness, treatment and control of hypertension continues a trend that was started in 1994,” said Emanuela Falaschetti, M.Sc., lead author of the study and a statistician at University College London.

Researchers also found the use of medications changed from 2003 to 2006. In 2006, more than 60 percent of those treated were receiving two or more anti-hypertensive medications compared to 56 percent in 2003. Of one-, two-, three- or four-drug regimens, the single biggest percentage of people were on a two-drug regimen in 2006.

In April 2004, the Quality and Outcomes Framework (QOF) was introduced in the new General Medical Services (GMS) contract in the UK. In this pay-for-performance system, general practitioners receive compensation for achieving various clinical targets, with points and payments awarded according to the level of achievement. As a voluntary part of the new GMS contract, general practices can aspire to achieve all, part or none of the points available in QOF. Most practices with a GMS contract have participated fully.

One of the measured achievements is lowering blood pressure levels to less than 150 millimeters of mercury (mm Hg) systolic and less than 90 mm Hg diastolic. The potential impact of this aspect of practitioners’ new contract on blood pressure control in the population has not been evaluated in any rigorous way using a population-based sample in England. However, a recent study on data from general practices from April 2004 to March 2007 attributed for the first time improved blood pressure monitoring and control in the UK to the physician pay-for-performance incentives.

“Controlling blood pressure is one of the most cost-effective ways of reducing the risk of heart attacks, strokes and deaths,” Poulter said. “The control rates we have witnessed in England are big, probably the best in Europe in controlling blood pressure. This can be put down to the increased use of medications and highlights the fact that it can be done.”

In an accompanying editorial, Sailesh Mohan, M.D., and Norm R.C. Campbell, M.D., of the University of Calgary, Canada, wrote: “It is critical to discern the impact of Performance for Pay on hypertension management so that other countries can assess the potential to improve hypertension management using this tactic. The basis for improved hypertension in England prior to and following the introduction for pay for performance requires more rigorous exploration.”

Despite improving trends, hypertension rates in England are far from the optimum and “more intensive efforts are clearly warranted to prevent and control hypertension so that a meaningful impact can be achieved in reducing hypertension-associated cardiovascular disease,” they wrote.

The Department of Health and the NHS Information Centre for health and social care funded the two surveys.

Other co-authors are: Moushumi Chaudbury, M.Sc., nutritionist; and Jennifer Mindell, M.B., B.S., Ph.D. Individual author disclosures are available on the manuscript.

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Soccer Players Dissatisfied With Physique

Body composition, anthropometrical dimensions and morphological characteristics play a key role in the success of soccer players. The objective of the new study was to evaluate the body composition and body image of a group of top-flight soccer players and compare the results with those of a group of university students used as control subjects.

Marta Arroyo, lead author of the study and researcher at the University of the Basque Country explained to SINC that “the initial hypothesis was that athletes in general and, in this case, soccer players, have a better perception and are more satisfied with their body image than young men their age with similar weights who do not play sports professionally”.

Researches did not find significant differences in body image satisfaction between the soccer players and the control subjects. However, “the university students perceived their image much more precisely than the soccer players”, said Arroyo.

The body composition study revealed that soccer players had more muscle mass and less fat than the control subjects; that is, they were thinner and more defined than the volunteer group. It is important to note that the professional soccer players are required to check these parameters periodically.

“While the control subjects tended to want a more muscular body with the same amount of fat or less than they had, the soccer players expressed that they wanted more muscle mass, but also more body fat”, the researcher told SINC.

The soccer players’ ideal image was more like that of the rest of the young men their age. “This shows that what is considered ideal from the point of view of sports is not the same as what is considered an ideal image from the social point of view”, she added.

A total of 56 individuals took part in the study; half of them were soccer players and half university students. The soccer players who participated in the study play in the Junior Honor Division, 3rd Division and 2nd Division B in the Spanish league. “Currently, some of them have played with Real Sociedad’s top team, while others play on 2nd division teams”, said Arroyo.

To assess body image, the researchers used a computer program that showed participants real silhouettes on which they could modify several parameters, such as muscle mass or body fat. The soccer players and the control subjects used this technique to select the image with which they identified and the one they would like to have; their ideal.

The experts expect the results to be useful to all people who work in the field of sport nutrition and in areas related to psychology. “Although body composition is very important in the selection of soccer players, aspects related to satisfaction and body image are becoming more and more important”, the researcher concludes.

Full bibliographic information: Marta Arroyo, Jos© Manuel González-de-Suso, Celia Sánchez, Laura Ansotegui, Ana M. Rocandio. “Body image and body composition: comparisons of young male elite soccer players and controls”. International Journal of Sport Nutrition and Exercise Metabolism 16:628-638 diciembre de 2008.

Image Caption: Match between Real Sociedad and Gimnastic de Tarragona. Photo: Óscar Alonso Algote.

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Carbon Nanotube Avalanche Nearly Doubles Current Capacity

By pushing carbon nanotubes close to their breaking point, researchers at the University of Illinois have demonstrated a remarkable increase in the current-carrying capacity of the nanotubes, well beyond what was previously thought possible.

The researchers drove semiconducting carbon nanotubes into an avalanche process that carries more electrons down more paths, similar to the way a multilane highway carries more traffic than a one-lane road.

“Single-wall carbon nanotubes are already known to carry current densities up to 100 times higher than the best metals like copper,” said Eric Pop, a professor of electrical and computer engineering at the U. of I. “We now show that semiconducting nanotubes can carry nearly twice as much current as previously thought.”

As reported in the journal Physical Review Letters, the researchers found that at high electric fields (10 volts per micron), energetic electrons and holes can create additional electron-hole pairs, leading to an avalanche effect where the free carriers multiply and the current rapidly increases until the nanotube breaks down.

The sharp increase in current, Pop said, is due to the onset of avalanche impact ionization, a phenomenon observed in certain semiconductor diodes and transistors at high electric fields, but not previously seen in nanotubes.

While the maximum current carrying capacity for metallic nanotubes has been measured at about 25 microamps, the maximum current carrying capacity for semiconducting nanotubes is less established. Previous theoretical predictions suggested a similar limit for single-band conduction in semiconducting nanotubes.

To study current behavior, Pop, graduate student Albert Liao and undergraduate student Yang Zhao first grew single-wall carbon nanotubes by chemical vapor deposition from a patterned iron catalyst. Palladium contacts were used for measurement purposes. The researchers then pushed the nanotubes close to their breaking point in an oxygen-free environment.

“We found that the current first plateaus near 25 microamps, and then sharply increases at higher electric fields,” said Pop, who also is affiliated with the Beckman Institute and the Micro and Nanotechnology Laboratory at the U. of I. “We performed repeated measurements, obtaining currents of up to 40 microamps, nearly twice those of previous reports.”

By inducing very high electric fields in the nanotubes, the researchers drove some of the charge carriers into nearby subbands, as part of the avalanche process. Instead of being in just one “lane,” the electrons and holes could occupy several available lanes, resulting in much greater current.

The avalanche process (which cannot be observed in metallic carbon nanotubes because an energy gap is required for electron-hole multiplication) offers additional functionality to semiconducting nanotubes, Pop said. “Our results suggest that avalanche-driven devices with highly nonlinear turn-on characteristics can be fashioned from semiconducting single wall nanotubes.”

Funding was provided by the National Science Foundation and the National Institute of Standards and Technology through the Nanoelectronics Research Initiative.

James E. Kloeppel, Physical Sciences Editor, University of Illinois at Urbana-Champaign

Image Caption: Electrical and computer engineering professor Eric Pop, from left, worked with undergraduate Yang Zhao and graduate student Albert Liao, both in ECE, to demonstrate a remarkable increase in the current-carrying capacity of carbon nanotubes. Photo by L. Brian Stauffer

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MESSENGER Continues Hunt For Vulcanoids

MESSENGER reaches its orbital perihelion today and passes within 0.31 astronomical units (AU) of the Sun (one AU is nearly 150 million kilometers or 93 million miles). The mission’s imaging team is taking advantage of the probe’s proximity to the fiery sphere to continue their search for vulcanoids ““ small, rocky asteroids that have been postulated to circle the Sun in stable orbits inside the orbit of Mercury.

Vulcanoids are named after Vulcan, a planet once proposed to explain unusual motions in Mercury’s orbit. Scientists have long suspected that these small, faint “space rocks” exist. There is a gravitationally stable region between the orbit of Mercury and the Sun, which means that any objects that originally formed there could have remained for billions of years and might still be there today. All other such regions in the solar system are occupied by some type of debris (e.g., Trojan asteroids at stable points along the orbits of Jupiter and Neptune and Kuiper Belt objects near and beyond the orbit of Pluto).

The so-called vulcanoid region between the orbit of Mercury and the Sun is the main gravitationally stable region that is not known to be occupied. The region is, however, the most difficult to observe. Any vulcanoids would be difficult to detect from Earth because of the strong glare of the Sun. Previous vulcanoid searches have revealed no bodies larger than 60 kilometers in diameter. But MESSENGER’s travels in near-Mercury space enable a search for vulcanoids from a vantage never before attempted, says MESSENGER Science Team Member Clark Chapman, who is spearheading the team’s search along with his associate, William Merline.

“With MESSENGER, we can search for vulcanoids as small as 15 kilometers across,” said Chapman, a senior scientist at the Southwest Research Institute in Boulder, Colorado. Between February 7 and 11, the wide-angle camera of MESSENGER’s Mercury Dual Imaging System will have snapped 256 images in the areas east and west of the Sun. Because of the danger of the Sun’s glare, the camera will have to peek just past the probe’s sunshade to capture images.

“We are making the same observations on each day,” MESSENGER team member Nancy Chabot explained. “This cadence will allow us to reject cosmic rays and to distinguish, by its motion, the class of each object imaged” (e.g., vulcanoid vs. near- or inner-Earth asteroid).

The team carried out a similar imaging campaign over a nine-day period in June 2008, capturing 240 images of the outer portions of the would-be vulcanoid belt. “This sequence was designed to refine our observing techniques, assess limiting magnitudes, verify detectability of known objects, and make an initial search,” Chapman explained.

“Vulcanoids, should they be found, may provide scientists with insights into the conditions prevalent in the early solar system,” Chapman said. “In particular, if they exist or once existed, they would represent an additional population of impactors that would have cratered no other planet but Mercury, implying that the geological processes on Mercury have happened more recently than we would calculate if we assumed that Mercury’s craters formed at rates equivalent to cratering on the Moon and Mars.”

If vulcanoids are found not to exist, then we could be more confident that most of Mercury’s volcanic plains formed billions of years ago, as on the Moon, according to Chapman. The absence of vulcanoids would also focus scientists’ thinking on why vulcanoids never formed or, if they did form, why they are no longer there.

The Mercury-bound MESSENGER spacecraft will be assaulted by temperatures as high as 700°F as it orbits the planet closest to the Sun, and the only thing that will stand between its room-temperature science instruments and the blistering heat is a handmade ceramic-cloth quilt just one-quarter of an inch thick. Carl Jack Ercol, the man largely responsible for making sure that MESSENGER will be able to stand up to such harsh heat once imagined he’d make his living in a darker, much cooler environment: the coal mining industry.

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Enzyme Appears To Stunt Growth Of Breast Cancer Cells

Japanese scientists have reported discovering an enzyme that may suppress breast cancer cells and inhibit growth.

Writing in the journal Nature Cell Biology, scientists found that an enzyme called CHIP successfully suppressed breast cancer in mice.

Two kinds of human breast cancer cells were injected into mice ““ one carried the CHIP enzyme and the other did not. Scientists noted that tumors were far smaller among those who had been injected with the set carrying the CHIP enzyme.

Junn Yanagisawa, from the University of Tsukuba, Japan, and colleagues hope their findings will be used to design new treatments and drugs that target growth and metastasis.

“Our conclusion is that we have found that CHIP protein prevents breast tumor growth and metastasis,” Yanagisawa told Reuters.

Yanagisawa added that CHIP while acts to target the gene regulator SRC-3, it is also known to degrade a number of cancer causing proteins.

“In breast tumor treatments, measurement of the CHIP protein levels in the tumors may be valuable information for the treatment. Furthermore, designing a new therapy that increases CHIP protein levels or its activity could be useful for breast tumor treatment,” Yanagisawa said.

Breast cancer is the second most common form of cancer in the world, killing more than 500,000 people each year.

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Marburg Fever Confirmed In Colorado Patient

Authorities at the U.S. Centers for Disease Control and Prevention (CDC) reported that the country’s first case of Marburg hemorrhagic fever has been confirmed in a patient in Colorado.

The patient contracted the illness during a trip to Uganda, and has since recovered from the rare disease, which is caused by a virus indigenous to Africa.  The virus is spread through contact with infected animals or the bodily fluids of infected people.

Authorities did not disclose the identity of the patient.

A CDC spokesman said that no previous cases of Marburg hemorrhagic fever have been reported in the United States.

The patient had traveled to Uganda, and had spent time in a python cave in Maramagambo Forest in Queen Elizabeth Park, encountering fruit bats that can carry the Marburg virus.

The Ugandan government had closed the cave after a Dutch tourist died from Marburg in July.  The Colorado patient was treated in January 2008 at Lutheran Medical Center, and sought follow-up care in July after learning of the Dutch tourist’s death.

Pierre Rollin, acting chief of the Special Pathogens Branch of the CDC, told the AP that specialized tests of the initial sample obtained in January 2008 confirmed the illness.

Identifying the virus and determining the way in which a particular patient contracted it can be problematic, according to CDC officials.   It often depends on the timing and the quality of the sample being tested, since samples obtained early in the patient’s illness make it easier for authorities to identify the virus.

Marburg hemorrhagic fever is extremely rare. Indeed, fewer than 500 confirmed cases have been identified by the CDC since the virus was first recognized in 1967, the agency said on its Web site.   However, it is a serious disease, with more than 80 percent of the known cases having been fatal.

The Marburg virus has an incubation period of 5 to 10 days. Initial symptoms include headaches, fever and chills, which substantially worsen after the fifth day of illness.

Rollin said the CDC is testing hospital staff to determine whether any illnesses were undetected at the time.

Kim Kobel, a Lutheran hospital spokeswoman, said none of the staff and physicians who cared for the patient have developed symptoms of the disease.

Image Caption: Marburg virions (Image: CDC USA)

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Darwin’s Diaries Reveal Meticulous, Caring Husband, Dad

The name Charles Darwin is synonymous with the infamous theory of evolution that infuriated many because it conflicted with the Biblical view of creation. However, not many know that his theory also launched problems in Darwin’s marriage with his very religious wife, Emma.

“Darwin tried not to hurt his wife,” Ruth Padel, the naturalist’s great great granddaughter, told the Associated Press. “She said he seemed to be putting God further and further off. But they talked it through, and she said, ‘Don’t change any of your ideas for fear of hurting me’ ,” she said.

The 1859 release of “On the Origin of Species” altered scientific reason evermore and produced resistance that exists even now. With Darwin’s 200th birthday approaching on Feb. 12, there are more than 300 birthday celebrations in Britain alone, where Darwin’s face is on the 10-pound bill.

Other events are planned, including the Second World Summit on Evolution on the Galapagos Islands. In Australia, the Perth Mint is releasing a commemorative silver coin. Even those opposed to Darwin’s theories admit that he is an important figure.

“He was clearly extremely important, his thinking changed the world,” said Paul Taylor, a spokesman for Answers in Genesis, a group that denies Darwin’s theory of evolution.

“We disagree with his conclusions, with the way he made extrapolations, but he was a very careful observer and we’ve got a lot to be grateful for.”

Bob Bloomfield, a director at London’s Museum of Natural History, thinks that Darwin was careful not only because he was concerned about his wife, but also because he knew that the theory was controversial.

“He knew he had to make an absolutely iron-cast case for his theory,” Bloomfield said. “He was one of the earliest true scientists where everything he was prepared to write about had to be based on evidence.”

Darwin’s handwritten diaries are on display to the public at an exhibit at the Museum of Natural History, including specimens he collected. The diaries may provide insight into Darwin’s scrupulous, analytical approaches.

Darwin even listed the reasons why he should, and should not, get married.

In the end, Darwin agreed to the union: “One cannot live this solitary life, with groggy old age, friendless & cold, & childless staring one in ones face, already beginning to wrinkle,” he concluded.

That’s where his real life was,” Padel said about the diaries, a commended poet. “He had the most amazing sense of wonder. He was always thinking, ‘How does that work?’ And that led him to everything.”

Stephen Keynes, a great-grandson, stated that Darwin also recruited his children to toss flour on bees so their paths could be followed.

“He was the most wonderful father, ever,” said Keynes, 81. “He allowed his children access to his study where he was working at any time.”

Darwin was a regular visitor to the London Zoo, where he was a friend to an orangutan named Jenny. He gave Jenny a mouth organ and a mirror to see her reflection. He wrote that when she was denied an apple, she sulked like a child. These notes aided Darwin in developing his idea that man evolved from primates.

“He was very interested in the expressions of animals and in particular primates and how similar they could be to humans,” said Becky Coe, an education director at the zoo.

Darwin’s curiosity lasted longer than his physical energy.

“Late in life when he was quite ill, he would look at plants curling up at the window, bending to the light, and he would wonder, ‘How do they do that?'” said Padel. “He was constantly thinking of relationships and that led him to understand natural selection. He realized that every population is in competition with every other. He realized that is how species adapt, because they are always competing for light, water and food.”

What does Padel think he would be doing if he were living today?

She says he would most likely be investigating DNA and the immune system. She also thinks the scientist would be online a lot.

“He’d be a demon at e-mail,” Padel said.

On the Net:

Plague Bacteria Wiped Out Nuns

Nuns and priests risked their lives to care for plague victims in Renaissance France, says a new study that associates contact with infectious plague victims to the demise of many religious order constituents.

The study is one of the first to discover that the plague, a fatal bacterial disease called “the Black Death,” can be swiftly and precisely found in ancient human remains.

A few women who perished after aiding plague victims were Benedictine nuns that lived in the Sainte-Croix Abbey’s chapter house near Poitiers, France.

“The Abbess of Sainte-Croix was known to be an extremely generous person who spent all of her life looking after the poor,” lead researcher Raffaella Bianucci told Discovery News.

Bianucci, an anthropologist in the Department of Animal and Human Biology at the University of Turin, says that the abbess was the Countess Charlotte Flandrina of Nassau, fourth daughter of Prince William I of Orange.

When the countess took her religious vows, she gave the majority of her valuables to help pay for food and medical attention for the region’s unfortunates, several of whom got the plague from soldiers combating in the Thirty Years War.

“There is evidence of food distribution to the people, and it seems that laymen had free access to the convent’s infirmary,” Bianucci said.

Historical records imply that the nuns helping the plague victims got the disease between 1628 and 1632. During this time, General Vicar Jean Filleau demanded that the surviving nuns depart the cloister and house themselves in a seaside abode.

Bianucci and her research team examined the skeletons of Saint-Croix Abbey nuns whose remains were discovered lying on disinfectant calcium oxide, or lime.

The researchers put an “RDT dipstick test” on the bones and the teeth. Comparable to a home pregnancy test, the “dipstick” colors if it finds the occurrence of markers for Yersinia pestis, the plague bacteria.

The nuns tested positive for the plague, says the study, soon to be in print in the March issue of the Journal of Archaeological Science.

The scientists also executed the plague test on priests lain to rest at the altar of Saint-Nicolas’ Church in La Chaize-le-Vicomte, in the central area France. They tested positive for the disease as well.

Even though historical records are vague about the priests’ involvement with the plague victims, Bianucci thinks that the men surely were in contact with “the parishioners, as their ministry required, and certainly assisted people who were dying,” like giving the dying the last rights.

“It will be most interesting to see it (the plague dipstick test) applied to a wide array of tissues of varying ages in the future,” stated Arthur Aufderheide, director of the Paleobiology Laboratory at the University of Minnesota’s Medical School.

Image 1: Countess Charlotte Flandrina of Nassau

Image 2: Scanning electron micrograph depicting a mass of Yersinia pestis bacteria (the cause of bubonic plague) in the foregut of the flea vector. Credit: Rocky Mountain Laboratories, NIAID, NIH

On the Net:

Could Erectile Dysfunction Herald Heart Disease?

Men with erectile dysfunction may also have an increased risk for developing heart disease, said an expert at Baylor College of Medicine in Houston.

“There have been numerous studies demonstrating that cardiovascular disease and erectile dysfunction are linked,” said Dr. Mohit Khera, an assistant professor in the Scott Department of Urology at BCM specializing in male and female sexual dysfunction.

“Fifteen percent of men who have had erectile dysfunction will develop some form of cardiovascular adverse event within the next seven years. It may be the first sign or predictor for problems that will occur years from now.”

Khera said there are similarities between the blood flow in the heart and the penis. However, blood flow problems show up in the penis sooner.

“Penile arteries are much smaller than coronary arteries and thus are much more sensitive to cholesterol, plaque formation and hypertension (high blood pressure), thus the penis may get less blood flow,” said Khera. “If your penile arteries are clogged, then your coronary arteries could be next.”

Men who have erectile dysfunction should be screened for heart disease, especially if they have other risk factors, Khera said. “If a man has erectile dysfunction and has two or more cardiac risk factors, I refer him for a cardiac evaluation,” he said.

Cardiac risk factors include:

  • Obesity
  • High blood pressure
  • Diabetes
  • Smoking
  • High levels of circulating fat in the blood stream
  • High cholesterol

“The endothelium or inner lining of blood vessels regulates how the heart relaxes and contracts. When there is a problem with this, you have bad blood flow and develop heart disease,” said Khera. “We now know that endothelial malfunction in the penis causes erectile dysfunction.”

“One of seven men who develop erectile dysfunction today will develop cardiovascular disease in the coming years,” said Khera. “If we could identify these patients, we could save lives.”

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US Approves Drug From Genetically Altered Goats

On Friday, U.S. health officials approved the first drug made using genetically engineered animals in the midst of concerns about genetic implications.

ATryn, made by GTC Biotherapeutics, is a drug that is manufactured using milk from goats that have been scientifically altered to produce extra antithrombin, a protein that acts as a natural blood thinner.

The drug aims to prevent excessive blood clots in patients with a disorder known as hereditary antithrombin deficiency.  The company estimates that this disorder affects anywhere from 60,000 to 600,000 people in the United States.

The drug was approved by the Food and Drug Administration to help prevent blood cots from surgery or childbirth in patients with the condition, but no wider use to treat the disorder itself, the company said in a statement.

The company had been looking for approval for both uses, and earlier predicted the drug could generate $40 million to $50 million in annual sales in the U.S. in the first five years on the market.

“The approval of Atryn marks a significant milestone in the development of this innovative recombinant technology,” GTC Chairman and CEO Geoffrey Cox said in a statement.

According to GTC, about 1 in 5,000 people do not produce enough antithrombin protein.  As a result, their blood is more likely to stick together, occasionally causing clots that can travel to the lungs or brain, causing death.  Half of patients with the disorder experience their first life threatening clot before age 25.

Women that are pregnant and have the disorder are at higher risk of miscarriage or stillbirth, because of blood clots in the placenta.

Currently, patients suffering from hereditary antithrombin deficiency are prescribed conventional blood thinners, such as Plavix from Bristol-Myers and Sano-Aventis. 

Some genetic safety and animal advocates have raised doubts about using so-called transgenic animals to make pharmaceuticals, saying the FDA needs to provide more information about genetically engineered animals.

Last month, the FDA issued final guidelines on its plans to regulate animals who’s DNA had been altered.  It has yet to show a genetically engineered animals for human consumption.  Agency officials said they aimed to make the regulatory process more transparent, but some critics said they did not go far enough.

A policy analyst for the nonprofit group Center for Food Safety, Jaydee Hanson, said treating GTC’s goats as a drug rather than as an animals left many questions unanswered, such as what would happen to the goats that die.  Dead animals are sometimes processed for pet food.

“This is a backdoor way to approve genetically engineered animals,” Hanson told Reuters.

The goats that GTC uses are bred using cell injected with human DNA.  The company has a herd of about 200 at its Massachusetts facility.  GTC also says that the heard is otherwise normal and healthy.

The company said that the drug is licensed to Ovation Pharmaceuticals Inc. in the U.S. and should be available by the second quarter this year.

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Study Links Violent Video Games To Anti-Social Behavior

A new study suggests the frequency and type of video games played among young college students appears to parallel risky drug and alcohol use, poorer personal relationships, and low levels of self-esteem.

Laura M. Padilla-Walker, an associate professor at the School of Family Life at Brigham Young University, told Reuters Health the findings do not necessarily mean that every person who plays video games has low self-worth, or that playing video games will lead to drug use.

“The findings simply indicate video gaming may cluster with a number of negative outcomes, at least for some segment of the population,” she said.

The study looked at the previous 12-months’ frequency and type of video game and Internet use reported by 500 female and 313 male U.S. undergraduate college students.

The students involved with the study also recounted their drug and alcohol use, perceptions of self-worth and social acceptance, as well as the quality of their relationships with friends and family.

Padilla-Walker said the findings showed stark gender differences in video game and Internet use.

The research showed young men played video games three times as often as young women and reported playing violent video games nearly eight times as often.

Young women more often used the Internet for email and schoolwork, while young men were more likely to use the Internet for entertainment, daily headline news, and pornography.

Gender differences aside, the study noted correlations between frequent gaming and more frequent alcohol and drug use and lower quality personal relationships, as well as more frequent violent gaming and a greater number of sexual partners and low quality personal relationships.

Similar negative outcomes were linked with Internet use for chat rooms, shopping, entertainment, and pornography, but a contrasting “plethora of positive outcomes” with Internet use for schoolwork were also cited.

“These findings as a starting point for future research,” Padilla-Walker said.

Her team concluded that continued analyses of video game and Internet use should improve the overall understanding of health and development among emerging young adults.

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Link Between Control Of Chromosome Duplication, Segregation Discovered

Team finds that Orc1, part of machinery that initiates DNA replication, prevents excess centrosome duplication

Before a cell can divide into two, first it must duplicate its genetic material–the DNA packed in its chromosomes. The two new sets of chromosomes then have to be separated from one another and correctly distributed to the resulting “daughter” cells, so that both daughter cells are genetically identical to the original, or “parent,” cell.

During cell division, a cellular organ called the centrosome, and a copy of the centrosome, position themselves at opposite ends of the dividing cell. Each centrosome serves as an anchor for a spindle, a complex structure of filament-like tubules that radiates out from each centrosome and connects with special sites called centromeres on the chromosomes. By pulling on the chromosomes, the spindles separate them into two sets, each divided equally into the two emerging daughter cells.

It’s crucial that cells duplicate their centrosome only once during each division cycle. Extra copies can result in incorrect distribution of chromosomes, which can lead to genomic instability and cancer. Hence the importance of new research by Professor Bruce Stillman, Ph.D., and his lab group at Cold Spring Harbor Laboratory (CSHL). They have identified a protein molecule that controls the copying of the centrosome in human cells and prevents it from being re-duplicated. Their findings will appear in the February 6th issue of the journal Science.

Double duty for Orc1

The molecule shown by Dr. Stillman and his colleagues to control centrosome duplication is Orc1, one of six proteins that comprise the Origin Recognition Complex. ORC, as it is called, is an assembly that attaches to particular sequences within all the DNA in the cell and prepares it for duplication. Recently it had become clear that some ORC proteins might be doing more than jump-starting DNA duplication; the accumulation of extra centrosome copies in cells that lack ORC suggested that some or all ORC proteins might play a role in centrosome duplication as well.

To investigate which of the ORC proteins limit centrosome copying, Stillman and co-investigators Adriana Hemerly, Supriya Prasanth and Khalid Siddiqui, used RNA interference, or RNAi, a technique that uses small pieces of RNA to shut off specific genes. They blocked the production of each of the proteins that combine to form ORC in human cells. Loss of Orc1 alone, the scientists found, spurred cells to accumulate excess centrosomes.

Cells that were induced to produce more Orc1, on the other hand, had the normal amount of centrosomes, even when centrosomes were induced to re-duplicate via drug treatment of cells. It was thus deduced that Orc1 allows cells to duplicate centrosomes once per division cycle, but prevents centrosomes from being re-duplicated.

This new role for Orc1 seems to be separate from its duties in helping cells copy DNA. The CSHL team found that a shortened version of Orc1 that lacked the ability to start DNA duplication was still able to limit centrosome copying to once per cell-division cycle.

Orc1 forces new centrosomes to stay in touch

Within each centrosome are a pair of tiny machines called centrioles. These duplicate during cell division to produce two centriole pairs. Stillman’s laboratory found that Orc1 also controls the number of centrioles in a cell. Before a pair is copied, the two centrioles normally stay connected to each other. Upon the cell’s commitment to cell division, however, the centriole pair is duplicated to produce two new centriole pairs; this occurs precisely as copying of the chromosomes gets under way.

Stillman’s team hypothesizes that it is this “engagement” of the paired centrioles that stops the original centriole pair from duplicating. In cells that lacked Orc1, the CSHL scientists found that the centrioles were “disengaged” from the original, suggesting that Orc1 might prevent re-duplication by helping the new centrosomes to stay connected to the old.

This function of Orc1 depends on its ability to physically associate with the centrosomes, the researchers showed. They suggest that Orc1 is ferried to the centrosomes by the action of a protein known as Cyclin A. This protein is found at high levels in cells at the start of the division cycle and helps cells make one copy of their DNA.

But a related protein called Cyclin E may be the target of Orc1. Cyclin E, which was also found to associate with Orc1, is known to be required for centriole and centrosome duplication and also stimulates the duplication of DNA in chromosomes. Orc1 antagonizes Cyclin E activity so that it duplicates centrosomes but cannot re-duplicate them.

The scientists thus propose that Orc1 enforces the number of centrosome copies by moving to centrosomes during the short temporal window in the cell division cycle when Cyclin E is still present in the cell. “During this time, if the effects of Cyclin E activity aren’t counteracted by Orc1, centrosome re-duplication can occur,” explains Stillman.

“I also think that this discovery suggests an ancient link between the processes that duplicate DNA and the processes that separate the DNA in cells before cell division,” he added.

“Orc1 controls centriole and centrosome copy number in human cells” will appear in the February 6th issue of Science. The full citation is: Adriana S. Hemerly, Supriya G. Prasanth, Khalid Siddiqui and Bruce Stillman. Bruce Stillman is President of the Laboratory in addition to running his own research laboratory.

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Black Wolf Mystery Solved

The reason North American wolves have black coats may surprise you; scientists found it’s the result of historical matings between black dogs and gray wolves.

Gray wolves have that name because of their color, but in North America many of them have dark or black coats instead of the standard gray.

A team of researchers led by Gregory S. Barsh of Stanford University found a genetic mutation producing dark coats appears to have occurred in dogs, and then spread from them to wolves when the species mated.

The research, federally funded by the National Science Foundation, is published in the online edition of the journal Science.

Researchers discovered that dark-coated wolves are almost exclusive to North America and are common in forested areas where they make up 62 percent of the wolf population, compared with 7 percent in open tundra.

But wildlife biologists don’t think wolves rely much on camouflage, Barsh said. “It’s possible there is something else going on here.”

“It’s sort of intuitively appealing, when you see animals that sort of blend in with their environment, to say … that explains natural selection, that somehow they are better camouflaged either as predator or prey,” said Barsh.

However, he said wolves don’t have a lot of predators, and there’s no evidence a black coat color leads to any increase in a wolf’s ability to capture its prey.

The scientists used molecular genetic techniques to analyze DNA sequences from 150 wolves, about half of them black, in Yellowstone National Park, which covers parts of Wyoming, Montana and Idaho.

Researchers found that a mutated gene in dogs, known as the K locus, is responsible for black coat color.

The same protein responsible for coat color is associated with fighting inflammation and infection in humans.

Thus, it “might give black animals an advantage that is distinct from its effect on pigmentation,” Barsh said.

Researcher Tovi Anderson said humans have cultivated the mutation for black coats in the domestic dog for thousands of years.

“Now we see that it not only entered the wild population, but also is benefiting them,” she said.

Genetic tests show the mutation was introduced into wolves by dogs sometime in the last 10,000 to 15,000 years, Anderson said.

“We usually think of domestication as something that is carried out to benefit humans,” Barsh said. “So we were really surprised to find that domestic animals can serve as a genetic reservoir that can benefit the natural populations from which they were derived.”

“Although it happened by accident, black wolves are the first example of wolves being genetically engineered by people,” added co-author Marco Musiani of the University of Calgary in Canada.

“It is somewhat ironic that a trait that was created by humans may now prove to be beneficial for wolves as they deal with human-caused changes to their habitat.”

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Hollywood Studios Battle Digital Theft

Hollywood may at last be joining the ranks of Napster and other companies who are fighting back in the battle against what some companies call “digital theft.”

Media companies say that piracy is fast becoming a mainstream pursuit.  This digital looting comes at a time when sales of DVDs, a large percentage of film studio revenues, are trending downward.  Indeed, in 2008, DVD shipments plunged to their lowest levels in five years.  

Executives are now concerned that the recession will cause more users to view stolen shows and movies.

“Young people, in particular, conclude that if it’s so easy, it can’t be wrong,” Richard Cotton, general counsel for NBC Universal, told the New York Times.

For years people have exchanged illegal copies of TV shows, songs and films via the Internet.   However, the slow download process, often using a peer-to-peer technology called BitTorrent, required a healthy dose of patience and sophisticated users.

But now, with help from a simple search engine, users don’t need to even download such content.  Anyone can locate free copies of current movie releases still in theaters in a matter of minutes.  And classic TV shows, like every “Seinfeld” episode ever made, is also freely available for streaming, according to a New York Times report.

Some of these digital copies originate from bootlegs, while others are copies of the advance review videos that studios distribute prior to a release.

TorrentFreak.com, a German Web site that keeps track of which shows are downloaded the most, estimates that each episode of the NBC series “Heroes” is downloaded five million times at a substantial loss to the network.  The show averages roughly 10 million American viewers each week on TV.

A number of streaming sites are making it easier than ever to view free Hollywood content online.   Such sites allow users to start watching video immediately, without the need to transfer a full copy to their hard drive, making it easier than ever to view the free content online.

Since many of these sites are located in countries such as China with poor piracy enforcement efforts, they are difficult to monitor, and media firms do not have a true sense of just how much content is being stolen.

Many experts say the practice is becoming much more ubiquitous.

“Streaming has gotten efficient and cheap enough and it gives users more control than downloads do. This is where piracy is headed,” Forrester Research analyst James L. McQuivey told The New York Times.

“Consumers are under the impression that everything they want to watch should be easily streamable.”

Some of the initial battles over Internet video piracy involved YouTube, a Google -owned Web site that introduced many people to streaming.  

However, although some legal issues between YouTube and copyright owners remain, such as a $1 billion lawsuit filed by Viacom, the environment “has improved markedly,” said Mr. Cotton.

YouTube currently employs digital flags and filters to weed out illegal content.

However, if media companies are winning the fight against illegal video clips, they are losing the war over illicit copies of full-length films and TV episodes.  Indeed, illegal streams and downloads now comprise about 40 percent of the revenue the industry loses annually as a result of piracy, according to the Motion Picture Association of America (MPAA).

“It is becoming, among some demographics, a very mainstream behavior,” Eric Garland, CEO of BigChampagne, told the New York Times.

The files are alarmingly easy to locate, in part because of work by people like Mohy Mir, who started the Toronto-based video streaming Web site SuperNova Tube.

The site is run by Mr. Mir, 23, and one other employee, and allows anyone to post a video clip of any length.  As the site has grown in popularity, SuperNova Tube has become a warehouse for copyrighted content.

The new movies “Taken” and “Paul Blart: Mall Cop” could easily be found on the site in recent days by simply following “link farms,” links from other sites, which guide users to secret hoards of copyrighted content at various Web locations.

Mr. Mir says he was unaware the files were there, and that his company swiftly responds to requests from majority rights-holders.

He also says that piracy is actually his biggest problem, since advertisers tend to flee when they are made aware of any potential infringing material.  He said is constantly removing files at the request of Hollywood studios.

However, some might think Mr. Mir’s reluctance is contradicted by his site’s name and its slogan: “We Work with uploaders, not against them.”

The site’s name is based on the popular SuperNova BitTorrent hub.

“I think about getting sued every day. If that happens it will definitely take us out of business,” he told the New York Times.

Mr. Mir does indeed have cause for concern. In December, the MPAA sued three Web sites that it claimed were assisting copyright infringement by identifying and indexing Web links to pirated material.

The MPAA’s director of worldwide antipiracy operations, John Malcolm, told the New York Times that although the association does not sue individuals for viewing pirated films, additional lawsuits against Web sites are in the pipeline.  However, he admitted the challenge is fierce.

“There are a lot of very technologically sophisticated people out there who are very good at this and very good at hiding,” he said.

“We have limited resources to bring to the fight.”

With the vast amount of pirated material available online, Hollywood studios are turning to technological solutions to battle the problem.

Additionally, media firms are learning from the music industry’s mistakes and trying to avoid widespread implementation of piracy techniques.   The top lesson is providing video on a platform users want.

Mark Ishikawa, founder and CEO of Bay TSP’s, sees a relationship between the availability of content through legal means and their popularity on pirate networks.

“When DVD releases are postponed, demand always goes up, because people don’t have an authorized channel to buy,” he told the New York Times.

As a partial response to the piracy problem, a plethora of video Web sites now include the latest episodes of virtually every broadcast TV show.  

And studios are testing video-on-demand releases and other means to offer films on demand.   The studios hope that legal alternatives will stop the pirating.   By comparison, waited three years to provide legal options for online listeners.

“That’s how you start to marginalize piracy “” not just by using the stick, but by using the carrot,” said Mr. Garland.

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MIT Develops Device That Offers ‘Sixth Sense’

A portable “sixth sense” device powered by commercial products that can channel Internet information into daily routines has been developed by U.S. university researchers.

Massachusetts Institute of Technology (MIT) scientists have created a device that can turn any surface into a touch-screen for computer, controlled by simple hand gestures.

The device can even allow a user to take a photograph of a scene with their hands, or project a watch face with the proper time on a wrist when he or she makes a circle there with their finger.

The scientists from MIT cobbled a Web camera, a battery-powered projector and a mobile telephone into a gadget that can be worn like jewelry.  Signals from the camera and projector are relayed to phones with Internet connections.

“Other than letting some of you live out your fantasy of looking as cool as Tom Cruise in ‘Minority Report’ it can really let you connect as a sixth sense device with whatever is in front of you,” said MIT researcher Patty Maes.

At a Technology Entertainment Design Conference stage in Southern California Wednesday, Maes unveiled the futuristic device made from the store-bought components costing about $300.

The gadget can recognize items on store shelves, then retrieve and project information about products or even provide data with other choices that are prone to the users tastes.

It also can look at an airplane ticket and let him or her know whether their flight is on time, or even see books in a book store and project reviews or author information from the Internet onto blank pages.

“You can use any surface, including your hand if nothing else is available, and interact with the data,” Maes said.

“It is very much a work in progress. Maybe in ten years we will be here with the ultimate sixth-sense brain implant.”

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Deep Sea Study Returns With Climate Change Info, New Creatures

A research team returned from a month long underwater voyage that shed the light on never before seen species of fish and the effects of climate change in the deepest areas of the ocean.

Scientists from the California Institute of Technology and an international team of collaborators traveled around Tasmania, Australia with a 502-pound video camera.

The Eye-in-the-Sea is part of a new brand of scientific investigation to evaluate how global warming affects marine life.

“It was truly one of those transcendent moments,” says Caltech’s Jess Adkins. Adkins is the lead scientist and an associate professor of geochemistry and global environmental science at Caltech. “We were flying–literally flying–over these deep-sea structures that look like English gardens, but are actually filled with all of these carnivorous, Seuss-like creatures that no one else has ever seen.”

A preceding deep sea study used battery-operated instruments. However, the new camera uses real time data that streams to the shore, allowing researchers to have an improved comprehension of how pollution is affecting the ocean.

The ocean absorbs the majority of its carbon dioxide pollution from the burning of fossil fuels, creating increased acidity. Greenhouse gas pollution is also warming the ocean, a trend that can wipe out an extensive collection of marine life.

The area of the ocean being studied, the Tasman Fracture Zone, was previously explored at a depth of 5,900 feet. Using the new camera system, the researchers descended to 13,000 feet.

“We set out to search for life deeper than any previous voyage in Australian waters,” scientist Ron Thresher said.

“The revolution in oceanography is to replace expeditionary science with a permanent presence in the ocean in the deep sea,” added Widder.

“With rising sea levels as a result of ocean warming and ice caps melting, we need better observations recorded regularly and openly to better quantify what’s happening to the oceans and the planet,” said John Orcutt, a professor of geophysics at University of California.

The mission had two goals, stated Adkins: to try and use samples of deep-sea corals to recreate the paleoclimate and to comprehend the variations in CO2 discovered in the ice-core records.

Investigators also wanted to see the shifts in the ocean’s life over the last hundred to one thousand years ago.

“We want to see what’s happened to the corals over the Industrial Revolution timescale,” says Adkins. “And we want to see if we can document those changes.”

They also just wanted to see what is down there.

“In one sense, the deep ocean is less explored than Mars,” Adkins adds. “So every time you go to look down there you see new things, magical things.”

Amid the “magical things” discovered on the voyage was a new kind of carnivorous sea squirt that “looks and behaves like a Venus fly trap,” says Adkins; new kinds of barnacles and a brand new species of sea anemone dubbed by Adkins to be “the bane of our existence,” because it resembled the coral they were collecting.

The sea anemone was irritating, said the researchers, because they wanted to locate deep-sea samples of the fossilized coral, but could not find the coral below 7,800 feet.

“Not being able to find the coral down deeper was our single biggest disappointment on the trip,” says Adkins.

However, the 10,000 samples found will aid the researchers in their work of decoding what has been going on in the ocean during the centuries of climate change. They will begin by dating the fossils gathered to conclude what part of history they came from.

“The deep ocean is part and parcel of these rapid climate changes,” says Adkins. “These corals will be our window into what their impact is on climate, and how they have that impact. The info is there; now we just have to unpack it.”

Image 1: The coral the researchers were looking for, d. dianthus, can be seen in the upper middle of the picture. Its look-alike anemone, a new species, is below and to the left. Credit: Advanced Imaging and Visualization Laboratory, WHOI/Jess Adkins, Caltech

Image 2: This is one of the new species seen during the voyage of the RV Thompson. Credit: Advanced Imaging and Visualization Laboratory, WHOI/Jess Adkins, Caltech

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Singles: Valentine’s Day Doesn’t Have To Be Lonely

Does the sight of heart-shaped boxes of chocolate and cuddly teddy bears make you cringe at the idea of spending another Valentine’s Day alone? The over-hyped holiday can be hard on singles, said a behavioral sciences expert at Baylor College of Medicine, but there are plenty of ways to channel negative emotions.

“If people are fairly content not being in a relationship, then they’re not going to be quite as affected by the Valentine’s Day hype, but it can be very difficult for single people who want to be in a relationship,” said Dr. Catherine Romero, assistant professor in the Menninger Department of Psychiatry and Behavioral Sciences at BCM.

The first thing singles should do, Romero recommended, is to make sure they’re taking care of themselves by getting enough sleep, staying physically active, eating right and avoiding excessive alcohol use.

“If you’re already not taking care of yourself, you’re going to be a lot more vulnerable to extreme feelings of sadness or loneliness during this time,” she said.

Distraction is also a good strategy, Romero said. Surrounding yourself with friends and family or volunteering, for example, can make you feel good about yourself and take your mind off the Valentine’s Day hype.

“I also think it’s important to do something that sort of celebrates you on Valentine’s Day,” she said. “Treat yourself to something fun ““ a pedicure or something a little indulgent without going way overboard.”

Some of Romero’s other tips for singles on Valentine’s Day include:

-Don’t fall into the trap of thinking that if you’re not in a relationship now, you never will be.

-For those who attend a singles event on Valentine’s Day, have fun and keep an open mind, but don’t have the expectation that you must meet somebody. You may be setting yourself up for disappointment.

-Remember that Valentine’s Day does not just celebrate romantic love, but also the love between parents and children, siblings and even friends.

Romero cautioned that the holiday may cause some single people to start thinking about the reasons why they can’t find a relationship or make one work. Valentine’s Day may not be the right time to deal with this, however.

“It will probably be easier and more productive to focus your time on problem solving and identifying reasons why you’re not in a relationship and things that you might need to do to find a healthy relationship when you’re past this period of hype and increased emotion and vulnerability,” she said.

If feelings of loneliness and sadness don’t go away when Valentine’s Day is over, this could signify a deeper depression. Warning signs of depression include changes in sleeping patterns and appetite, trouble concentrating, sad moods that last all day, crying spells and thoughts of death or suicide. If these symptoms or behaviors last for more than two weeks, consult a physician or mental health specialist.

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Handedness May Be Linked To Fertility

A new study suggests people who are “mixed-handed,” those who are able to use both hands with equal dexterity, may have a harder time conceiving a child than righties or lefties.

A study of more than 9,000 Danish couples showed that those in which one partner was mixed-handed, rather than exclusively right- or left-handed, tended to take slightly longer to conceive.

Mixed-handedness, also known as cross-dominance, is being able to do different tasks better with different hands. For example, mixed-handed persons might write better with their right hand but throw a ball more efficiently with their left hand.

Lead researcher Dr. Jinliang Zhu of the University of Aarhus in Denmark said the findings suggest that mixed-handedness and lower fertility may share a common cause.

Zhu told Reuters Health it was possible that hormonal exposure during prenatal development affects both a person’s eventual handedness and his or her fertility.

The researchers wrote in the medical journal Epidemiology that the theory needs further study.

But numerous studies in the past have looked at the connection between handedness and health, and several linked being left-handed or mixed-handed to having a higher risk of some diseases and disorders, including breast cancer, schizophrenia, dyslexia and autism.

It has been theorized that people who are not right-handed had some type of exposure that interfered with brain development in the womb, such as abnormal hormonal levels.

Zhu’s study concluded that mixed-handedness in both men and women were related to a longer time to conceive.

However, he said that while the study raises the possibility of the two having a common cause, other explanations are also possible.

He acknowledged that it is still unclear whether mixed-handedness is a signal that something went wrong during a person’s fetal development. “So far we know little about the origins of handedness,” Zhu said.

“At this time, it is difficult to say that mixed-handedness is pathological.”

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Japanese scientists find archaean genes

Japanese scientists say they have made the world’s first discovery of genes, in jigsaw-like pieces, taken from an archaean living in a hot spring.

The Keio University researchers led by Professor Akio Kanai said their findings are expected to lead to an explanation of the origin and evolution of genes since archaeans, unicellular organisms, are one of the earliest forms of life on Earth.

The researchers said they discovered combinations of 3 individual RNAs produced from separate genes can generate transfer RNA that are essential for decoding the genomic information during protein biosynthesis. The scientists said they also discovered, through computational analysis and experimental verification, different tRNA genes are produced by various combinations of split tRNA.

It is hard to believe that long functional genes existed from the early time of ancient life. It may be possible that, as in the tRNA genes we’ve found, long genes may have evolved from the combination of short genes through trial and error, said graduate student Kosuke Fujishima, the first author of the research.

The scientists said their discovery represents a very rare phenomenon found in the deep-branching archaean and suggests that in ancient life, short genes could have been used in multiple combinations.

The study is reported in the Proceedings of the National Academy of Science.

Drugmakers Should Focus On Science Instead Of Marketing

As public trust in drugmakers and doctors is at an all time low, two Harvard professors have released a list of recommendations that they said should be taken in order to restore public confidence.

“We’ve seen a lot of transgressions — people who have taken advantage of the system for their own self-aggrandizement or profit. It’s got to stop,” said Dr. Harlan Krumholz of Yale University in New Haven, Connecticut.

Krumholz, alongside Professor Joseph Ross, came up with six proposals that would help drug companies and doctors regain public trust.

“The relationship between drug and device companies, the medical profession, and the public is at a critical juncture,” they wrote in the British Medical Journal.

“The public is well served when industry, clinicians, and academicians work together for the common good, generating new knowledge and ensuring appropriate and rapid dissemination of effective products to save lives and improve quality of life.”

Ross and Krumholz propose that the industry should do away with “promotional activities such as direct to consumer advertising and distribution of drug samples in settings where prescribing decisions are made.”

Secondly, they advise that doctors should not receive gifts, including notepads, pens or other promotional memorabilia.

“Small gifts may seem innocuous, but cognitive psychologists have shown that they have outsized influence.5 The value of the interaction between industry representatives and physicians should relate to information exchanged, not the gift received,” they said.

Third, they recommend that all clinicians, researchers, academic institutions, clinics, and hospitals should be completely transparent about gifts and payments from industry.

Additionally, physicians should fund their own education, therefore ending “industry sponsorship of continuing medical education.”

“Fifthly, industry sponsored clinical studies should be visible, accountable, and comply with mandatory standards set by institutional review boards, data safety and monitoring boards, and steering committees to protect patient volunteers,” they wrote.

And last, Ross and Krumholz advise that doctors and industry “defend free speech, and acknowledge that there is great value in the respectful exchange of ideas.”

“We need to overcome an unfortunate history of intimidation exhibited by some companies against physicians who have expressed opinions that did not favor their product,” they added.

Dr. Marcia Angell of Harvard Medical School in Boston said doctors should no longer be so closely linked to the drug industry.

“I believe there should be no relationship between the drug industry and either prescribers or patients,” wrote Angell, former editor of the New England Journal of Medicine.

“You might have to go down the local high school instead of playing golf in Hawaii, but the education would be better because it would be impartial,” she told Reuters Health.

Scott Gottlieb, a health policy analyst in Washington DC, said industry needs to be transparent in their interactions with doctors and patients, while focusing more on science than marketing.

“Relationships should be predicated on genuine scientific work,” he wrote.

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Meth Use Cost The US About $23 Billion In 2005

The economic cost of methamphetamine use in the United States reached $23.4 billion in 2005, including the burden of addiction, premature death, drug treatment and many other aspects of the drug, according to a new RAND Corporation study.

The RAND study is the first effort to construct a comprehensive national assessment of the costs of the methamphetamine problem in the United States.

“Our findings show that the economic burden of methamphetamine abuse is substantial,” said Nancy Nicosia, the study’s lead author and an economist at RAND, a nonprofit research organization.

Although methamphetamine causes some unique harms, the study finds that many of the primary issues that account for the burden of methamphetamine use are similar to those identified in economic assessments of other illicit drugs.

Given the uncertainty in estimating the costs of methamphetamine use, researchers created a range of estimates. The lowest estimate for the cost of methamphetamine use in 2005 was $16.2 billion, while $48.3 billion was the highest estimate. Researchers’ best estimate of the overall economic burden of methamphetamine use is $23.4 billion

The study was sponsored by the Meth Project Foundation, a nonprofit group dedicated to reducing first-time methamphetamine use. Additional support was provided by the National Institute on Drug Abuse.

“We commissioned this study to provide decision makers with the best possible estimate of the financial burden that methamphetamine use places on the American public,” said Tom Siebel, founder and chairman of the Meth Project. “This is the first comprehensive economic impact study ever to be conducted with the rigor of a traditional cost of illness study, applied specifically to methamphetamine. It provides a conservative estimate of the total cost of meth, and it reinforces the need to invest in serious prevention programs that work.”

The RAND analysis found that nearly two-thirds of the economic costs caused by methamphetamine use resulted from the burden of addiction and an estimated 900 premature deaths among users in 2005. The burden of addiction was measured by quantifying the impact of the lower quality of life experienced by those addicted to the drug.

Crime and criminal justice expenses account for the second-largest category of economic costs, according to researchers. These costs include the burden of arresting and incarcerating drug offenders, as well as the costs of additional non-drug crimes caused by methamphetamine use, such as thefts committed to support a drug habit.

Other costs that significantly contribute to the RAND estimate include lost productivity, the expense of removing children from their parents’ homes because of methamphetamine use and spending for drug treatment.

One new category of cost captured in the analysis is the expense associated with the production of methamphetamine. Producing methamphetamine requires toxic chemicals that can result in fire, explosions and other events. The resulting costs include the injuries suffered by emergency personnel and other victims, and efforts to clean up the hazardous waste generated by the production process.

Researchers caution that their estimates are in some cases based on an emerging understanding of methamphetamine’s role in these harms and should be further refined as understanding of these issues matures. The RAND report also identifies costs that cannot yet be adequately quantified.

“Estimates of the economic costs of illicit drug use can highlight the consequences of illegal drug use on our society and focus attention on the primary drivers of those costs,” Nicosia said. “But more work is needed to identify areas where interventions to reduce these harms could prove most effective.”

Methamphetamine is a highly addictive substance that can be taken orally, injected, snorted or smoked. While national surveys suggest that methamphetamine use is far from common, there is evidence that the harms of methamphetamine may be concentrated in certain regions. One indicator of the problem locally is treatment admissions. Methamphetamine was the primary drug of abuse in 59 percent of the treatment admissions in Hawaii in 2004 and accounted for 38 percent of such admissions in Arizona in 2004.

The report, “The Economic Costs of Methamphetamine Use in the United States – 2005,” is available at www.rand.org. Other authors of the report are Rosalie Liccardo Pacula, Beau Kilmer, Russell Lundberg and James Chiesa.

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Study Finds African-Americans More Distrusting Of Research Than Whites

Distrust toward medicine and research plays a significant role in African-Americans’ lack of participation in clinical trials, according to a study by researchers at Children’s Hospital of Pittsburgh of UPMC and the University of Pittsburgh Graduate School of Public Health.

African-Americans are significantly underrepresented in clinical research. A recent study published in the February issue of Archives of Pediatrics & Adolescent Medicine addresses the racial differences in parental trust toward medicine and research and their implications for enrollment of children into clinical research. The researchers found that enrollment of children into clinical research studies depends on parental attitudes, beliefs and expectations.

In a research survey of 190 parents (140 African-American and 50 white) of patients seen at Children’s Hospital’s Primary Care Center, African-American parents were twice as likely to be distrusting of medical research as white parents. This study was conducted by Kumaravel Rajakumar, MD, a pediatrician in Children’s Hospital of Pittsburgh’s Division of General Academic Pediatrics, in collaboration with Stephen Thomas, PhD, the Philip Hallen Professor of Community Health and Social Justice and director of the Center for Minority Health in the Graduate School of Public Health at the University of Pittsburgh.

“Parental distrust toward medicine and research can be a barrier for enrollment of children in clinical research studies. The higher levels of distrust among African-American parents can mean that they are less likely to enroll their children in clinical trials, which can have profound implications for eliminating racial and ethnic health disparities, as it impacts the extent to which research findings can be applied to the general population including minorities,” said Dr. Rajakumar, also an assistant professor of Pediatrics in the University of Pittsburgh School of Medicine. “Our study also found that financial and other incentives would only be moderately effective in increasing participation. As a medical community, we need to develop better strategies for overcoming the distrust of African-American parents to help achieve adequate participation of African-American children in clinical research.”

As compared with white parents, African-American parents:

  • More often reported distrust of medical research, when questions assessing trust were combined and analyzed (67 percent vs. 50 percent)
  • More often believed that physicians prescribe medications as a way of experimenting on unknowing patients (40 percent vs. 28 percent)
  • Were more likely to believe that medical research involves too much risk to the participant (46.8 percent vs. 26 percent), that physicians will not make full disclosures regarding their child’s participation (24.6 percent vs. 10 percent) and that research participants would be favored and receive better medical care (48.6 percent vs. 28 percent)
  • Education level also was associated with distrust, with high distrust scores among 74 percent of those with less than a high school education vs. 44 percent of college graduates. However, race remained associated with higher levels of distrust even after the researchers controlled for education, with African-American parents being two times more likely of being distrusting compared with white parents.

“Race matters,” Dr. Thomas said. “It is important for the biomedical research community to acknowledge that African-American distrust toward medicine and research is not irrational; on the contrary, it reflects the legitimate discontent of far too many black families who experience racial discrimination when seeking medical care along with the clear and convincing evidence of racial disparities in their health status compared with whites’. The experience of discrimination is not limited to one individual or one generation but is passed on through word of mouth, keeping alive the cultural memory of how medical science was used to justify the racial inferiority of African-Americans.”

The authors conclude that the use of culturally appropriate recruitment materials, as well as using research assistants with similar racial and cultural backgrounds as the subject population, can help provide accurate information and quell parental distrust toward clinical research. Additionally, the establishment of community research advisory boards, which provide feedback at all stages of a research study, as has been done in Pittsburgh, is another means to ensure that minority community members participate and disseminate information about studies while protecting the interests of research subjects and potentially reducing distrust.

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Children’s Hospital of Pittsburgh

New Evidence From Excavartions IN Arcadia, Greece

In the third century BCE, the Greek poet Callimachus wrote a ‘Hymn to Zeus’ asking the ancient, and most powerful, Greek god whether he was born in Arcadia on Mt. Lykaion or in Crete on Mt. Ida.

A Greek and American team of archaeologists working on the Mt. Lykaion Excavation and Survey Project believe they have at least a partial answer to the poet’s query. New excavation evidence indicates that Zeus’ worship was established on Mt. Lykaion as early as the Late Helladic period, if not before, more than 3,200 years ago. According to Dr. David Gilman Romano, Senior Research Scientist, Mediterranean Section, University of Pennsylvania Museum, and one of the project’s co-directors, it is likely that a memory of the cult’s great antiquity survived there, leading to the claim that Zeus was born in Arcadia.

Dr. Romano will present his team’s new discoveries””and their implications for our understanding of the beginnings of ancient Greek religion””at a free public lecture, The Search for Zeus: The Mt. Lykaion Excavation and Survey Project, Tuesday, January 27, 6 p.m. in the Rainey Auditorium of the University of Pennsylvania Museum. Reservations (suggested) may be made online through the Museum calendar (www.museum.upenn.edu), or by calling 215/898-4890.

New evidence to support the ancient myth that Zeus was born on Mt. Lykaion in Arcadia has come from a small trench from the southern peak of the mountain, known from the historical period as the ash altar of Zeus Lykaios. Over fifty Mycenaean drinking vessels, or kylikes, were found on the bedrock at the bottom of the trench along with fragments
of human and animal figurines and a miniature double headed axe. Also found were burned animal bones, mostly of goats and sheep, another indication consistent with Mycenaean cult activity.

“This new evidence strongly suggests that there were drinking (and perhaps feasting) parties taking place on the top of the mountain in the Late Helladic period, around 3,300 or 3,400 years ago,” said Dr. Romano.

In mainland Greece there are very few if any Mycenaean mountain-top altars or shrines. This time period “” 14th-13th centuries BC “” is approximately the same time that documents inscribed with a syllabic script called Linear B (an archaic form of the Greek language) first mention Zeus as a deity receiving votive offerings. Linear B also provides a word for an ‘open fire altar’ that might describe this altar on Mt. Lykaion as well as a word for a sacred area, temenos, a term known from later historical sources. The shrine on Mt. Lykaion is characterized by simple arrangements: an open air altar and a nearby sacred area, or temenos, which appears to have had no temple or other architectural feature at any time at this site.

Evidence from subsequent periods in the same trench indicate that cult activity at the altar seems to have continued uninterrupted from the Mycenaean period down through the Hellenistic period (4th ““ 2nd centuries BCE), something that has been documented at very few sites in the Greek world. Miniature bronze tripods, silver coins, and other dedications to Zeus including a bronze hand of Zeus holding a silver lightning bolt, have been found in later levels in the same trench. Zeus as the god of thunder and lightning is often depicted with a lightning bolt in his hand.

Also found in the altar trench was a sample of fulgurite or petrified lightning. This is a glass-like substance formed when lightning strikes sandy soil. It is not clear if the fulgurite was formed on the mountain-top or if it was brought to the site as a dedication to Zeus. Evidence for earlier activity at the site of the altar, from the Final Neolithic and the Early and Middle Helladic periods, continues to be found.

The Mt. Lykaion Excavation and Survey Project is a collaboration between the
University of Pennsylvania Museum of Archaeology and Anthropology in
Philadelphia, the University of Arizona, and the Greek Archaeological Service in Tripolis, Greece. Project directors are Dr. Romano, Dr. Mary Voyatzis of the University of Arizona, and Dr. Michalis Petropoulos, Ephor of Prehistoric and Classical Antiquties of the Greek Archaeological Service in Tripolis. The project is under the auspices of the American School of Classical Studies in Athens. Investigations at the Sanctuary of Zeus also include excavations and survey of a number of buildings and monuments from the lower sanctuary where athletic contests were held as a part of the festival for Zeus in the Archaic, Classical and Hellenistic periods. These include a hippodrome, stadium, stoa, bath, xenon (hotel building) and fountain house. The Project, which began in 2004, will continue in the summer 2009. Further information about the research project can be found at the project website: http://corinth.sas.upenn.edu/lykaion/lykaion.html

Support for the Mt. Lykaion Excavation and Survey Project comes from a number of foundations including the Karabots Foundation, the Samuel H. Kress Foundation, the 1984 Foundation, the Niarchos Program for the Promotion of the Hellenic Heritage at the University of Pennsylvania, as well as from numerous individual donors.

The University of Pennsylvania Museum of Archaeology and Anthropology, 3260 South Street on the University of Pennsylvania’s campus in Philadelphia, is dedicated to the study and understanding of human history and diversity. Founded in 1887, Penn Museum has sent more than 400 archaeological and anthropological expeditions to all the inhabited continents of the world. With an active exhibition schedule and educational programming for children and adults, the Museum offers the public an opportunity to share in the ongoing discovery of humankind’s collective heritage. The Museum can be found on the worldwide web at www.museum.upenn.edu. For general information call 215/898-4000.

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Virginia Tech

Driving Affected By Cold, Flu Symptoms

Some insurers claim that having a bad cold or the flu can significantly affect a driver’s responses, BBC News reported.

Lloyds TSB Insurance used a hazard simulator to test 100 drivers with a range of conditions including colds, stress and headaches and 50 who were healthy.

The research showed that drivers with colds scored, on average, 11 percent worse “” equivalent to the effect of a double whisky.

Experts said being ill could affect driving ability.

The PCP research agency performed a study on 60 people with colds and flu as well as 40 with other conditions including premenstrual syndrome and found that applying the 11 percent effect to reaction times would add 3.3ft to stopping distance if traveling at 30mph – on top of a normal distance of 40ft.

It would add 7.5ft onto the normal stopping distance of 315ft if traveling at 70mph.

YouGov carried out a separate poll of 4,000 people for the insurance companies, and found 22 people had had an accident while fighting a bad cold and five while they had flu.

Among the 33.5 million adults who in Britain, the YouGov figures would equate to 125,000 accidents caused last year by motorists with colds and flu.

The report warned that being sick at the wheel, particularly when combined with medication, fatigue or a small amount of alcohol, could all have a significant impact on a person’s ability to drive.

“Getting behind the wheel when ill causes thousands of accidents every year,” said Paula Llewellyn, a spokesperson for the company.

She advised people to try and avoid driving if suffering from cold or flu.

“Safe driving requires concentration and good reactions, both of which are significantly reduced, even by just a mild cold,” added Dr. Dawn Harper, who is supporting the campaign.

She suggested drivers suffering from these conditions should avoid getting behind the wheel until they are better.

“If you are not well enough to undertake a journey, it could be dangerous for yourself and other road users,” said Duncan Vernon, road safety manager at the Royal Society for the Prevention of Accidents (RoSPA).

He warned that severe bouts of common conditions, such as colds, flu, migraine, stomach upsets, infections and hay fever, can affect a driver’s ability to drive safely.

“A heavy cold, for example, can have symptoms that include a headache, blocked sinuses, sneezing and tiredness, and these can impair a driver’s mood, concentration, reactions and judgment.”

“It is important that, when you are ill, you weigh up how necessary journeys are and whether alternative arrangements can be made,” he added.

Vernon recommended a common sense approach is needed, as it is possible to drive safely when feeling ‘slightly under the weather’, but a point may be reached when it is unwise to drive.

“People need to be honest with themselves about their ability to drive safely.”

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Drinking Water During Labor Carries Risk

A new Swedish study finds that pregnant women who consume too much water during labor are at greater risk of hyponatraemia, a potentially dangerous condition that results when an excess of water causes levels of sodium in the bloodstream to fall.

The study revealed that women who drank more than 2.5 liters during labor had a 25 percent greater chance of hyponatraemia, which can produce nausea, vomiting, headaches or more dangerous problems if left unchecked. In severe cases it can cause swelling of the brain or even coma.

The study tracked 287 participants who were allowed to drink freely during labor.  Researchers took blood samples upon hospital admission and again after the birth. In total, 61 women consumed more than 2.5 liters of water, 16 of which were found to have hyponatraemia.

“We conclude that hyponatraemia is not uncommon following labor, and is potentially harmful, but is also easily avoidable,” said Dr Vibeke Moen of the Sweden’s Karolinska Institute, who led the study.

“Women should not be encouraged to drink excessively during labor, and the policy of liberal fluid administration should be questioned.”

Dr. Meon said further research is needed on whether lower blood sodium levels are linked with longer labors, as it might be influencing the ability of the womb to contract.

“At one time, a myth became prevalent that drinking lots of water each day was a healthy habit,” said Professor Philip Steer, chief editor of the obstetrics and gynecology journal BJOG, which published the current study.

“However, recent research shows clearly that in general, one can trust one’s natural body messages, and that we only need to drink more when we feel thirsty.”

Professor Steer recommends that doctors and midwives monitor how much water women drink during labor.

Gail Johnson of Britain’s Royal College of Midwives told BBC News she was unaware of any trend among midwives to ask women to drink water when not thirsty. Some British midwives encourage women to sip, rather than drink a lot, of water during labor.

“We’re not encouraging women to drink massive amounts of water, although perhaps we might suggest they take a sip to keep their mouths moist,” she said.

“One of the reasons is that the stomach does not empty as efficiently during labor, so drinking lots increases the risk of vomiting.

“The key thing is for the woman to listen to what her own body is telling her – many women would not want to drink much at all.”

The study was published in the journal BJOG.  An abstract can be viewed here.  

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How Vision Sends Messages To The Brain

New article in the FASEB Journal reports that scientists have finally captured the elusive signaling device our retinas use to tell us what we see

Scientists have known for more than 200 years that vision begins with a series of chemical reactions when light strikes the retina, but the specific chemical processes have largely been a mystery. A team of researchers from the United States and Switzerland, have she new light on this process by “capturing” this chemical communication for future study. This research, published in the February 2009 issue of The FASEB Journal, may lead to the development of new treatments for some forms of blindness and vision disorders.

At the center of the discovery is the signaling of rhodopsin to transducin. Rhodopsin is a pigment in the eye that helps detect light. Transducin is a protein (sometimes called “GPCR”) which ultimately signals the brain that light is present. The researchers were able to “freeze frame” the chemical communication between rhodopsin and transducin to study how this takes place and what goes wrong at the molecular level in certain disorders.

According to Krzysztof Palczewski, a senior scientist involved in the research, “The results may have important implications for discovery and development of more specific medicines to treat GPCR-linked dysfunction and disease.” Examples of health problems involving GPCR dysfunction include blindness, diabetes, allergies, depression, cardiovascular defects and some forms of cancer.

To make their discovery, scientists isolated rhodopsin/transducin directly from bovine retinas. These membranes were suspended in solution and exposed to light to start the chemical signaling process. After light exposure, any contaminating proteins were removed, and the remaining rhodopsin and transducin “locked” in their chemical communication were removed using a centrifuge. In addition to helping scientists understand how vision begins, this research may also impact disorders affecting heart beat, blood pressure, memory, pain sensation, and infection response because it is believed that they are regulated by similar chemical communications involving similar proteins.

“Until now, scientists have been in the dark when it comes to exactly how vision begins. This exciting new work shows how light becomes a chemical signal to the brain,” said Gerald Weissmann, Editor-in-Chief of The FASEB Journal. “Now that we see the light, so to speak, entirely new types of custom-fit become possible for a wide range of diseases.”

A recent and related article in The FASEB Journal on milestones in photochemistry is available at http://www.fasebj.org/cgi/content/full/22/12/4038.

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Scientists Fly Pole-To-Pole To Map Atmosphere

Scientists have completed the first of five pole-to-pole flights intended to determine how greenhouse gases travel.

The Harvard University-led project based in Colorado conducted the three-week $4.5 million mission using a high performance jet this month, and researchers have already reported valuable new findings.

Scientists left on January 8, aboard the specially equipped jet, which took air samples while flying from Colorado to the Arctic before heading back down to the Hawaiian Islands toward Antarctica. Researchers hope to be able to better understand how the Earth stores carbon dioxide.

“There’s a strong need to understand what the forests and oceans are doing now so we can predict whether or not they’ll continue to protect (us) in the future,” said Britton Stephens of the Boulder, Colorado-based National Center for Atmospheric Research (NCAR).

Their first findings show that carbon dioxide appears to be building up over the Arctic. This may be caused by industrial pollution and burning of trees over the last few centuries, scientists told Reuters on Thursday.

Using a specially equipped Gulfstream V aircraft, owned by the National Science Foundation (NSF) and operated by NCAR, scientists hope to have the first “Ëœmap’ of the atmosphere by the time they complete the three-year project.

“We were essentially retracing Captain Cook’s voyages ““ obviously much later and with much more sophisticated instruments ““ but with some very similar parallels,” said Stephens.

“When he set sail, he knew the ocean was out there, but didn’t really know the details. Similarly, we’ve been standing on the edge of the atmosphere – the surface ““ but we don’t really know the details.”

The research jet, known as the High-performance Instrumented Airborne Platform for Environmental Research (HIAPER), has a range of about 7,000 miles which allows scientists to traverse large regions of the Pacific Ocean without refueling, gathering air samples along the way, NCAR said.

Each of the remaining missions will follow similar routes and take place through mid-2011.

“We’re flying this wonderful plane all over the globe and taking a slice out of the atmosphere to see what’s in it,” said principal investigator Steven Wofsy of Harvard.

“It’s the first time we’ll be able to see the whole globe all at once in great detail. This is giving us a completely new picture of how greenhouse gases are entering the atmosphere and being removed from it, both by natural processes and by humans.”

On Thursday, NASA announced plans to launch a satellite next month to measure carbon dioxide in the atmosphere, and Japan is also working on satellite research.

Stephens told Reuters that data from flights on the research jet will complement some 20 models that predict how greenhouse gases move through the atmosphere. Until now, these models run by universities and governments, have been based on observations from the surface of the planet.

“By using the unique capabilities of the research jet, we are gaining tremendous insights into the atmosphere,” said Anne-Marie Schmoltner, who is helping to oversee the project as NSF section head for lower atmosphere research.

“Scientists who work with computer models will be busy for years using this information to refine our understanding of atmospheric processes and the role of greenhouse gases.”

Image Caption: The NSF/NCAR Gulfstream V research aircraft, known as HIAPER (High-performance Instrumented Airborne Platform for Environmental Research). (©UCAR, photo by Carlye Calvin)

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Acupuncture Being Used Increasingly By Military Physicians

The ancient practice of acupuncture has gained traction in recent years, taking steps toward being legitimized among medical professionals. Now, the practice is being increasingly used among the Air Force’s health providers as a way to reduce pain in troops who have been wounded in battle.

The Air Force runs the military’s only acupuncture clinic and has begun training doctors to use the practice on the field of combat in Iraq and Afghanistan.

A pilot program starting in March will prepare 44 Air Force, Navy and Army doctors to use acupuncture as part of emergency care in combat, according to the Associated Press.

Chief Warrant Officer James Brad Smith can attest to the benefits of acupuncture. He returned from battle to Walter Reed Army Medical Center in Washington. Having fallen 20 feet from a Black Hawk helicopter in Baghdad, Smith broke five of his ribs, punctured his lung and broke bones in his hand and thigh.

Recently, Air Force physician Col. Richard Niemtzow met with Smith to perform an acupuncture procedure. Niemtzow is responsible for the development of “battlefield acupuncture” in 2001. The technique uses shorter needles to better fit under combat helmets so soldiers can continue their missions with the needles inserted to relieve pain.

Revered by the ancient Chinese, acupuncture involves inserting small needles into specific points in the body in order to relieve pain.

During a recent procedure, Col. Niemtzow inserted gold alloy needles around Smith’s ear, and his pain began to subside.

“My ribs feel numb now and I feel it a little less in my hand,” Smith told the AP, raising his injured arm. “The pain isn’t as sharp. It’s maybe 50 percent better.”

Niemtzow said most of his patients say their pain decreases within minutes.

Now the Navy has begun trials of a program to train its physicians to use a form of acupuncture at Camp Pendleton in California.

According to AP, the US military first encountered acupuncture during the Vietnam War, when an Army surgeon wrote in a 1967 edition of Military Medicine magazine about local physicians who were allowed to practice at a U.S. Army surgical hospital and administered acupuncture to Vietnamese patients.

Niemtzow has been providing acupuncture for soldiers since 1995, when he worked at McGuire Air Force Base in New Jersey. Years later, he became the first full-time military medical acupuncturist for the Navy, which also provides health care for the Marines.

Niemtzow acknowledged that acupuncture will not cure a patient, but he referred to it as “another tool in one’s toolbox to be used in addition to painkillers.”

“In the beginning, many people were skeptical, but after seeing it demonstrated on patients and the benefits achieved — especially in the area of pain — the majority of physicians embraced it and learned how to use it in their practice as an adjunctive therapy,” said Niemtzow.

“The history of military medicine is rich in development,” he said, “and a lot of people say that if the military is using it, then it must be good for the civilian world.”

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Process Found to Play Role in Rheumatoid Arthritis Could Lead to New Treatment

Although the origin of rheumatoid arthritis (RA) remains unclear, bioactive proteins known as cytokines, particularly TNFÃŽ± and IL-6, which are involved in inflammation, play a major role in the disease by contributing to joint and tissue destruction. Placenta growth factor (PIGF), another cytokine, has been thought to be critical for a new blood vessel formation in the placenta to sufficiently deliver oxygen and nutrients to fetus. A new study examined the effects of PIGF on the inflammatory process of RA. The results suggest that PIGF may play an important role in inflammation in RA joints. The study was published in the February issue of Arthritis & Rheumatism (http://www3.interscience.wiley.com/journal/76509746/home).

Led by Wan-Uk Kim of Catholic University of Korea inSeoul, Korea, researchers analyzed blood and synovial fluid cells from RA patients and healthy controls and found that synovial cells were the major source of PIGF production in RA patients and that PIGF stimulates TNFÃŽ± and IL-6 production. They also found that the PlGF-induced increases in TNFÃŽ± and IL-6 production may be caused by high levels of flt-1, a PlGF receptor, which are linked to the inflammatory response of RA patients. In addition, the researchers identified a novel peptide to inhibit PlGF action. When injected into arthritic mice, this peptide reduced the severity of arthritis and prevented its progression. They also found that elimination of PIGF gene in mice prevented the development of antibody-induced arthritis.

The peptide they identified inhibits binding of PIGF to its receptor flt-1and could be valuable from a clinical standpoint, since it is easily synthesized and does not elicit unwanted immune response.

“These findings provide new insight into the pathogenic mechanism of RA and emphasize the importance of PIGF and flt-1 as potential candidates for therapy, in addition to their being a common cue of angiogenesis and the inflammatory process,” the authors conclude. They are currently conducting research to improve the activity of the anti-flt-1 peptide by modifying its structure and length.

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Wiley-Blackwell

Researchers Have Developed Test For Mad Cow Disease

A blood test has been developed by Canadian researchers that can diagnose fatal chronic wasting disease in elk, and may provide an inexpensive approach to screening for mad cow disease.

According to the researchers, the test looks for damaged cells in the blood, and may also provide a way to diagnose Creutzfeldt-Jakob disease in humans.

The report appears in the journal Nucleic Acids Research.

“We can now take a blood sample from a live animal and look at the DNA patterns in the blood and predict six months ahead of time whether an animal is infected with chronic wasting disease,” said Christoph Sensen of the University of Calgary.

The secret, according to Sensen, is that they look for circulating nucleic acids which are released by dying cells instead of searching for the prions that cause mad cow disease.

Researchers discovered three patterns in these circulating strands of DNA that appeared three months prior to elk showing symptoms of disease.  Each pattern could be linked to a genetic mutation that puts the animal at risk of catching the disease.

Transmissible spongiform encephalopathies (TSEs) such as mad cow disease, chronic wasting disease, and CJD destroy the brain, and can be transmitted when an animal eats another’s infected tissue.

In the 1980s, mad cow disease swept through Britain infecting herds and people who ate contaminated beef products. 

Fewer than 200 people globally have died by contracting the disease in this manner.

Outbreaks of mad cow disease can halt a nation’s beef exports, so governments and breeders are enthusiastic about an inexpensive way to test for mad cow disease.

According to Sensen, the test they have developed is a simply polymerase chain reaction (PCR) that intensifies the DNA so it may be sequenced.

The researchers suggest pooling the blood of several animals for traces of BSE.  If traces are found, then individual tests can be performed.

Sensen and his team tested their methods on 19 elk and two BSE-infected cattle from Germany.  The researchers were able to identify the infected animals each time.

It may take up to four years to replicate the findings in cattle, said Sensen.

“There is currently no reliable way to tell if an animal may have a prion infection before it becomes obviously sick,” said Kevin Keough of the Alberta Prion Research Institute.

“If there were a reliable way to know, it would be of great benefit to producers, processors and wildlife managers.”

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New York City Starts Push To Reduce Dietary Salt

After a series of victories that include a smoking ban, a ban on trans fats and mandating restaurants to post the calorie contents of their foods, New York City is now waging a new campaign to clamp down on the amount of sodium New Yorkers consume.

Dr. Frieden, the commissioner of New York City’s Department of Health and Mental Hygiene, said the initiative would be aimed at packaged foods and mass-produced restaurant meals, which contribute 80 percent of the sodium in a typical American’s diet.

During a luncheon last October, Dr. Frieden made his case to some of the biggest names in food processing, telling executives the city sought to reduce sodium levels by 25 percent within the next five years, and 50 percent within a decade.

During an interview last week, Frieden suggested he might seek legal action against companies that don’t comply.

“If there’s not progress in a few years, we’ll have to consider other options, like legislation,” he said.

Dr. Frieden’s last foray into the nutrition arena involved his support of a nationwide move to ban trans fats and to list calorie counts on restaurant menus.

“The one thing that’s disturbing is that he seems to be able to do just about anything he wants in New York City, and New York City serves as a model for the rest of the world,” said E. Charles Hunt of the New York Restaurant Association told the New York Times.

However, this campaign will likely prove more difficult for Dr. Frieden in both practical and political terms.  For one thing, salt is harder to remove from the nation’s food supply, and its link to cardiovascular disease is less understood.  Also, the food industry claims it is already addressing sodium levels.

Furthermore, the scale and scope of Dr. Frieden’s plan, which seeks to enlist a majority of the major food and restaurant companies to do the same thing simultaneously, is ambitious.

Reducing salt consumption and quitting smoking are two areas in which a broad public health effort can have the most impact on the most people, the New York Times quoted Dr. Frieden as saying.

The gradual reduction of sodium levels, so customers don’t notice the difference, is a critical component of the plan. 

“We’ve created a whole society of people accustomed to food that is really, really salty. We have to undo that,” Dr. Sonia Angell, director of cardiovascular health for the city, told the New York Times.

Because other nutritional culprits have been in the spotlight lately, sodium reduction has often lingered in the background.  And while most heart researchers agree that high blood pressure is a leading factor in the incidence of stroke and heart attack, salt does not cause high blood pressure in everyone.

But supporters of a salt reduction campaign say that while hypertension is often treated with medications, not everyone has access to the drugs.  And many patients ignore their doctors’ recommendations to cut back on consumption of salt.

That’s why Dr. Frieden says a subtle, large-scale reduction in sodium levels  might be a more effective approach.  Lowering sodium levels by half, he said, would save up to 150,000 American lives each year.

Dr. Frieden’s plan is modeled after one in Britain, which sets sodium reduction targets for certain categories of food like breakfast cereals, cheese, bread, pasta products, cake mixes, soups and condiments.  The ultimate targets will be based on a formula that factors in the amount of sodium in a product as well as how much food in that particular category people consume.

However, the Dr. Frieden’s goal is not to force small bakers or high-end chefs to abstain from using salt.  Rather, health officials believe large food companies can have the most significant impact on sodium consumption.

“If they bring it down by 5 percent, that is going to do more than Danny Meyer bringing it down by 50 percent,” Geoffrey Cowley, an associate commissioner of the Health Department, told the New York Times, in reference to the New York restaurateur.

Although Dr. Frieden’s jurisdiction includes only New York City, he is touting his plan as a “national salt-reduction initiative”.  Indeed, the campaign has the support of six other health departments around the country, along with organizations like the American Medical Association.

Dr. Frieden convened his series of salt talks to expand his idea beyond the city.  The first discussions took place last October,  when he asked companies like PepsiCo, Unilever and Goya to Gracie Mansion.   And he plans to meet with a number of chain restaurant executives in February.

Some in the Health Department thought the October luncheon was so successful they celebrated over drinks later that day.   But some industry leaders took a different view.

“I would say the invitations to come to Gracie Mansion weren’t very inviting,” a New York Times report quoted a food company executive as saying. 

There was certainly a sense of “ËœDon’t make us shame you.’ “

Robert Earl, the Grocery Manufacturers Association’s vice president for science policy, nutrition and health, said his members would prefer more of a national campaign that includes a broader variety of players, including consumer and advocacy groups.

There are other problems as well, he said. Getting many companies to do the same thing simultaneously could have antitrust implications.   And further research is required to understand what consumers are seeking, as well as the complex health implications of sodium reduction.

The association issued its own sodium policy paper on January 12.

“We need to look at these things more holistically and over the long term,” Mr. Earl told the New York Times.

The federal government has been looking at sodium levels for years. During the 1980s, federal dietary guidelines advised against excess sodium.  Shortly thereafter, the U.S. Food and Drug Administration (FDA) called on the food industry to voluntarily cut sodium levels in processed foods.

However, that didn’t work, and by 2000 men consumed 48 percent more salt than they did in the early 1970s, according to the most recent data from a large national study.  Women consumed 69 percent more sodium. The trend was due, in part, to saltier foods, along with the growing consumption of calories the average person consumed during that time.

The federal Institute of Medicine is expected to release a comprehensive study on sodium this year that could alter national dietary guidelines.  Current guidelines call for people consume no more than 2,300 milligrams of sodium a day.  However, some food labels set an upper limit of sodium of 2,400 milligrams for a 2,000 daily calorie diet.   That’s equivalent to teaspoon of salt, half of what many people typically consume.  African-Americans, older people and others prone to high blood pressure are advices to consume much less sodium.

The food industry is also considering the issue of sodium reduction.  The grocery manufacturers’ group and the National Restaurant Association each held sodium conferences recently in which finding an attractive salt substitute was a central theme.

“It’s frankly been one of those holy grails in the food industry for a number of years,” Todd Abraham, a senior vice president for Kraft foods, told the New York Times.

Kraft has invested $20 million on sodium reduction research, experimenting with yeast or potassium as potential substitutes and studying chemicals that block taste receptors.

Although it’s fairly easy for food makers to reduce topically applied salt, such as that on potato chips, salt’s role in processing packaged foods goes beyond flavor. For instance, while potato chips may taste saltier, they typically contain less sodium than foods such as muffins.  Such items use salt to create structure and to encourage browning.  Salt also helps emulsify ingredients in foods such as American cheese and bologna, and helps keep pathogens at bay.

Nevertheless, sodium levels can vary greatly within food categories.  For instance, Sam’s Choice Thick and Chunky salsa has about twice the amount sodium as Muir Glen organic salsa.

Beyond other obstacles, Dr. Frieden might see some scientific resistance in his battle against salt.   Some medical researchers question whether mass sodium reduction is the best way to allocate scarce public-health resources when weight loss and smoking cessation would do more for the country’s heart health.

People’s reactions to salt are often based on their genes, and some are more sensitive than others.  In fact, for some people even relatively low levels of sodium can be unhealthy.

However, public health officials say there is a broad consensus that salt leads to higher rates of heart attacks and strokes.

That view concerns Dr. Michael Alderman, editor in chief of the American Journal of Hypertension, who believes more clinical studies are needed, and emphasizes that wild swings in dietary regulation haven’t always produced results.

For instance, health officials once promoted the trans fat form of margarine as healthier than butter, a belief later found untrue.  Indeed,  it turns out that trans fats were far worse for cardiovascular health than saturated fats.

“Diet is an incredibly complicated business,” Dr. Alderman said.

On the Net:

Seismic Slip And Tremor Linked, With Subduction Zone Implications

In the last decade, scientists have recorded regular episodes of tectonic plates slowly, quietly slipping past each other in western Washington and British Columbia over periods of two weeks or more, releasing as much energy as a magnitude 6 earthquake.

The slip events coincide with regular occurrences of what scientists call nonvolcanic tremor, which showed up clearly on seismometers but for which the origins were uncertain.

Now researchers from Italy and the University of Washington have concluded that both phenomena are signs of the same processes taking place about 25 miles deep at what is believed to be the interface between the Juan de Fuca and North American tectonic plates.

“We are now more confident that the tremor and the slip are both products of the same slip process,” said Kenneth Creager, a UW professor of Earth and space sciences and a co-author of a paper describing the research being published Jan. 30 in Science.

The findings could have major implications for megathrust earthquakes in the Cascadia subduction zone, an area along the West Coast from northern California to southern British Columbia. Megathrust events are huge earthquakes, often in the range of magnitude 9, that occur in areas where one tectonic plate is forced beneath another.

The slow slip events appear to be building stress on the megathrust fault, where the Juan de Fuca plate is sliding beneath the North American plate, with the two locked together most of the time. That pressure is relieved when the plates slip during megathrust earthquakes such as one determined to have occurred off the coast of Washington on Jan. 26, 1700, estimated at magnitude 9.2. That quake was similar to the great Sumatra-Andaman Islands earthquake the day after Christmas in 2004, which also measured 9.2 and triggered a devastating Indian Ocean tsunami.

In such events, the plates are locked together for hundreds of years and then slip past each other by sliding 50 feet or more during a megathrust earthquake.

“The same amount of slip must also occur onshore along the Washington coast,” Creager said. “While megathrust earthquakes account for most of the plate motion offshore, and perhaps slightly onshore, episodic tremor and slip harmlessly accommodates much of the plate motion that is taking place on plate interface just west of the Puget Sound region’s major population centers.”

The paper’s lead author is Mario La Rocca of Italy’s National Institute of Geophysics and Volcanology Vesuvius Observatory. Other authors are Danilo Galluzzo, also of Italy’s geophysics and volcanology institute, and Steve Malone, John Vidale, Justin Sweet and Aaron Wech of the UW.

Slip events occur on the interface between tectonic plates, but previous research has suggested that nonvolcanic tremor occurs in a broad range of depths from the plate boundary to 15 miles above it. The new research indicates the tremor is at the plate boundary, in essentially the same place as the slip.

The researchers used seismometer arrays at Sequim and Lopez Island in Washington state and at Sooke on the southern edge of Canada’s Vancouver Island to record an episodic tremor and slip event in 2004. La Rocca devised a novel method using the different times that specific waves generated by the tremor were detected by seismometers, and the data helped the scientists pinpoint the depth of the tremor. At the same time, GPS measurements recorded the slow plate slippage.

Since they were discovered in the last decade, slow slip and tremor events in western Washington and British Columbia have been recorded on a regular basis about every 15 months. GPS signals indicate slip of about 1 inch during an average episode.

“We are quite confident that each episodic tremor and slip event will increase the stress on the megathrust fault,” Creager said. “If a megathrust earthquake were to begin off the Washington coast, one might expect it to occur during one of these slow slip events.”

But he said the findings demonstrate that much research remains to be done.

“We’re just scratching the surface in understanding how all of this works.”

The work was funded by Italy’s National Institute of Geophysics and Volcanology, the National Science Foundation and the U.S. Geological Survey.

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‘Rescue Course’ Of Antenatal Steroids Improves Outcome In Preemies

In a study to be presented today at the Society for Maternal-Fetal Medicine’s (SMFM) annual meeting, researchers will unveil findings that show that premature babies born before 34 weeks have a 31 percent reduction in serious complications when given a “rescue course” of Antenatal Corticosteroids (ACS) steroids with no adverse side effects noted.

“Premature babies are very susceptible to respiratory problems which may lead to additional severe complications,” said Dr. James Kurtzman, M.D. (Associate Professor, UC Irvine Medical Center). “Antenatal steroids clearly reduce the risk of these respiratory complications.”

Years ago doctors gave multiple courses of antenatal steroids to mothers who were at risk for delivering prematurely. However, certain studies found that there were possible adverse affects to multiple ACS courses because babies were found to have slightly smaller head circumferences and lower birth weights. As a result the National Institutes of Health (NIH) recommended further study.

“The effect (of the NIH recommendation) was that doctors were only giving one ACS course, and they were nervous about when to give it for the best effect. They often waited until the last minute, and some women didn’t get a complete treatment or didn’t get it at all,” said Dr. Kurtzman. “What this study has found is that we can give women who threaten to deliver prematurely an initial ACS course, and if they remain pregnant, we can give one ‘rescue course’ closer to delivery. By doing so, the babies’ complications are reduced by about a third with no adverse side effects found.”

In this study, which took place over five years in 18 different medical centers and was supported by the Pediatrix Medical Group, 437 patients were randomized (233 in the study group, and 214 in the placebo group). The results showed a significant reduction in composite neonatal morbidity for babies born prior to 34 weeks in the “rescue steroid” group vs. placebo (43.9% vs. 63.6%) as well as significant decrease in respiratory distress syndrome, ventilator support, and surfactant use. When all neonates were included in the analysis (regardless of the gestational age at delivery), a significant reduction in composite morbidity in the “rescue steroid” group was still demonstrated (32.1% vs. 42.6%).

The study was authored by James Kurtzman, M.D., University of California Irvine and Saddleback Women’s Hospital; Thomas Garite, M.D., University of California Irvine; Reese Clark, M.D., and Kimberly Maurel, R.N., M.S.N., Pediatrix Medical Group on behalf of the Pediatrix Collaborative Research Network..

The study will be published in the March 2009 issue of the American Journal of Obstetrics and Gynecology.

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Some Climate Troubles Should Face Burial At Sea

Making bales with 30 percent of global crop residues ““ the stalks and such left after harvesting ““ and then sinking the bales into the deep ocean could reduce the build up of global carbon dioxide in the atmosphere by up to 15 percent a year, according to just published calculations.

That is a significant amount of carbon, the process can be accomplished with existing technology and it can be done year after year, according to Stuart Strand, a University of Washington research professor. Further the technique would sequester ““ or lock up ““ the carbon in seafloor sediments and deep ocean waters for thousands of years, he says.

All these things cannot be said for other proposed solutions for taking carbon dioxide out of the atmosphere, methods such as ocean fertilization, growing new forests or using crop residues in other ways, says Strand, who is lead author of a paper on the subject in the journal Environmental Science & Technology, published by the American Chemical Society.

Strand has devised a formula to measure the carbon-sequestration efficiency of this process and others using crop residues, something no one has done before.

Carefully tallying how much carbon would be released during the harvest, transportation and sinking of 30 percent of U.S. crop residues and comparing that to how much carbon could be sequestered, Strand says the process would be 92 percent efficient. That’s more efficient than any other use of crop residue he considered, including simply leaving crop residue in the field, which is 14 percent efficient at sequestering carbon, or using crop residue to produce ethanol, which avoids the use fossil fuels, but is only 32 percent efficient.

Worldwide, farming is mankind’s largest-scale activity. Thirty percent of the world’s crop residue represents 600 megatons of carbon that, if sequestered in the deep ocean with 92 percent efficiency, would mean the amount of carbon dioxide in the atmosphere would be reduced from 4,000 megatons of carbon to 3,400 megatons annually, Strand says. That’s about a 15 percent decrease.

The proposed process would remove only above-ground residue. Strand bases his calculations on using 30 percent of crop residue because that’s what agricultural scientists say could sustainably be removed, the rest being needed to maintain carbon in the soil. Crop residue would be baled with existing equipment and transported by trucks, barges or trains to ports, just as crops are. The bales would be barged to where the ocean is 1,500 meters, or nearly a mile, deep and then the bales would be weighted with rock and sunk.

“The ocean waters below 1,500 meters do not mix significantly with the upper waters,” Strand says. “In the deep ocean it is cold, oxygen is limited and there are few marine organisms that can break down crop residue. That means what is put there will stay there for thousands of years.”

The article calls for research on the environmental effects of sinking crop residues in the ocean, effects that most likely will be borne by organisms living in the ocean sediments where the bales fall.

Strand says one way to minimize environmental effects would be to drop the residue onto alluvial fans found off the continental shelf wherever rivers pour into the ocean. Alluvial fans, sometimes call submarine fans when underwater, form as silt and debris from river water settles to the seafloor. Runoff from current agricultural fields means alluvial fans in the ocean are already partly made up of crop residue. Any bales dumped there would quickly be covered with silt, further ensuring the carbon would be sequestered for long periods.

Effects might also be minimized by concentrating the residue in a compact area. At the Mississippi alluvial fan in the Gulf of Mexico, spreading 30 percent of U.S. crop residue in an annual layer 4 meters, or 13 feet, deep would cover 260 square kilometers, or 100 square miles. That’s about 0.02 percent of the area of the Gulf of Mexico, Strand says.

“Whatever the environmental impacts of sinking crop residue in the oceans turn out to be, they will need to be viewed in light of the damage to oceans because of acidification and global warming if we don’t remove carbon dioxide from the atmosphere,” Strand says.

Co-author of the paper is Gregory Benford, a professor of physics at the University of California, Irvine.

Strand, a faculty member with the UW’s College of Forest Resources, is an environmental engineer known for his work on using plants to remediate contaminated groundwater, soil and sediment. He said he’s been interested in ways to remove carbon dioxide from the atmosphere for nearly a decade and first read about sequestering crop residue in the deep ocean in Climatic Science in 2001. Benford was a co-author on that paper.

Strand says he thinks any method for removing excess carbon dioxide must do seven things: move hundreds of megatons of carbon, sequester that carbon for thousands of years, be repeatable for centuries, be something that can be implemented immediately using methods already at hand, not cause unacceptable environmental damage and be economical. He says sequestering crop residue in the deep ocean fits the criteria better than any other proposed solution.

“To help save the upper ocean and continental ecosystems from severe disruption by climate change, we must not only stop our dependence on fossil fuels, but also go carbon negative,” Strand says. “Fossil fuels that are removed from sediments and burned are producing the increased atmospheric carbon that is driving climate warming. Sequestering crop residue biomass in the deep ocean is essentially recycling atmospheric carbon back into deep sediments.”

“Ocean Sequestration of Crop Residue Carbon: Recycling Fossil Fuel Carbon Back to Deep Sediments” is available online to subscribers of Environmental Science & Technology (see Jan. 12) and is expected to appear in the print edition next month.

Image 2: Just past the continental shelf in the Gulf of Mexico ““ the shelf is marked with the blue line ““ a fan of sediment has formed on the seafloor made up of silt and debris that settles out of Mississippi River waters flowing into the gulf. These alluvial, or submarine, fans are found wherever rivers run into the ocean. Crop residues sunk in such fans would become covered with silt, further ensuring that carbon would be locked away for long periods. Credit: S. Strand/UW/U.S. Geological Survey

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