Growth in Research Comes at a Steep Price

A study released this month confirms and quantifies what many medical school deans and financial administrators have long understood: Basic science research can be an expensive luxury. The study, which was conducted by the University of Rochester School of Medicine and Dentistry, found that the school had to add 40 cents to every dollar of external grant support received by newly recruited scientists in order to achieve financial equilibrium. This is in contrast to support required for established scientists, which is considerably less.

“The benefit of research, both to an institution and society, is greater than the sum of the parts,” said David Guzick, M.D., Ph.D., dean of the University of Rochester School of Medicine and Dentistry and a co-author of the study. “However, grant revenue never comes close to paying for the total cost of research. This is especially true in the start-up phase of newly hired investigators.”

The authors are quick to point out that, regardless of the financial implications, research should remain a core mission of academic medicine in that this activity is critical for the advancement of medical knowledge. Research is also an important source of prestige, and an institution’s national reputation is often closely linked to the success (and size) of its research enterprise ““ an important factor in the competition for faculty, patients, partnerships, and philanthropy. Furthermore, in places like Rochester, academic medical centers play an important role in their local economies, both as employers and as a source of technological innovation for biotechnology and medical device companies. But these benefits come at a cost.

The study, which appears in the January edition of Academic Medicine, followed 25 basic biomedical science faculty members who were recruited to the University of Rochester between 1999 and 2004. Of that number, 23 were hired from outside the University. At the time, the University of Rochester Medical Center (URMC) was in the midst of a major expansion of its biomedical research enterprise which included two new buildings, several new research centers, and a push to increase the number of scientists and research funding.

Total expenses for the 25 faculty members, as well as the revenues they obtained through grant support, were calculated through 2006. Over this period, the researchers were highly successful at generating research revenue; cumulatively they were awarded $99.7 million extramural research grants, measured in 2006 dollars. Of that amount, $70.7 million directly supported their research (salaries, lab supplies, equipment expenses, etc.) and $29.1 million was indirect support ““ revenue provided by funding agencies such as the National Institutes of Health to help defray overhead costs of the scientists’ home institution. Other potential sources of revenue generated directly by the scientists ““ such as philanthropy, royalty revenue from intellectual property, and clinical and education revenue ““ were found to be minimal.

The report’s authors then tallied the start-up costs associated with the 25 faculty. This included recruitment packages that consisted of salaries and benefits for the scientists and their research assistants not recovered by grants, laboratory renovations, equipment, and other costs. The total amount provided by the school in the form of start-up packages for these 25 scientists was $33.1 million.

The study also calculated the indirect costs born by the school to support each of the researcher’s activities. This included a prorated share of the school’s overall facility and administrative expenses, such as utilities, housekeeping, research administration and oversight, and shared research resources and technologies. The indirect (overhead) expenses associated with the 25 scientists over the eight year period were $35.9 million.

The medical school’s cumulative expenses for the group were $69 million ($33.1 million in start-up and $35.9 million in indirect costs), of which the school was able to recover only $29.1 million in the form of indirect revenue from granting agencies, for a shortfall of $39.9 million. Thus, every dollar of research funding brought in by the scientists required an additional 40 cents of support from the school. To plug this hole, the medical school was compelled to tap other forms of revenue such as its endowment, philanthropy, royalty revenue from its licensed technologies, and transfers from other divisions of the Medical Center.

“Basic science is not necessarily a self funding activity,” said neurologist Ray Dorsey, M.D., the lead author of the study. “It often requires substantial support from an institution above and beyond the research grants and indirect revenue it receives from NIH and other funding sources.”

While conventional wisdom is that, once scientists begin to build a portfolio of research grants, this revenue will cover the cost of research and institutional overhead expenses, this is not the case. Other studies have shown that universities must contribute anywhere between 15 to 20 cents for every research dollar received by established faculty to support their research missions.

However, the University of Rochester study showed that this disparity is even more pronounced when start up costs for new faculty are added to the mix, a factor that has significant implications for institutions that are looking to expand their research enterprise and climb the rankings ladder in terms of research funding. The Rochester study shows that additional costs associated with recruiting a new scientist essentially doubles the subsidy that medical schools must pay to support their work.

“The investments that academic health centers must make in order for basic science to occur are growing, much of which will never be fully recovered,” said Dorsey. “This report illustrates that while funding agencies such as the NIH continue to play a leading role in biomedical research, other sources of revenue such as philanthropy, medical school endowments, and private and government support are of equal and increasing importance to the advancement of science.”

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Student Teams Selected To ‘Fly Their Theses!’

Four teams of postgraduate students have been selected to fly their experiments during a new ESA program called ‘Fly Your Thesis!’.

This exciting program, launched by the ESA Education Office in 2008, offers a rare opportunity for students to design, build, and eventually fly, a scientific experiment that requires an investigation to be performed in microgravity, as part of their Masters or PhD thesis. The chosen teams will participate in a series of parabolic flights on the Airbus A300 Zero-G aircraft.

During the final phase of the selection process, 16 student teams were asked to write a scientific proposal and make an oral presentation during a workshop held at the European Astronaut Center in Cologne, Germany, in early December 2008. 

At the end of this workshop, a jury composed of experts from the ESA Education Office, ESA’s Directorate of Human Spaceflight and ELGRA (European Low Gravity Research Association) made the selection of the four teams to be offered flight opportunities.

The selected teams are:

  • Complex, a team of four students from the Norwegian University of Science and Technology, in Trondheim, Norway. They will study the flow birefringence of a solution of clay particles in salty water, allowing them to have a deeper understanding of the self-organization of those small particles.
  • The Dust Side of the Force, a team of four German students from the Institute of Planetology at the University of Mnster, Germany. The experiment is about the greenhouse and thermophoretic effect, which can lift particles off the ground in low gravity conditions. This effect is thought to be important in planet formation and the formation of dust storms on Mars.
  • AstEx, a team of two British students from the Open University in the United Kingdom and the University of Nice-Sophia Antipolis, France. Their experiment will investigate the behavior of granular material under shear stress, with the possibility of using their results in the design of future asteroid sample return missions.
  • ABCtr MicroG, a team of three students from the Autonomous University of Barcelona and the Polytechnic University of Catalonia in Spain. Their experiment will investigate the behavior of particular biological agents involved in the assimilation of drugs by the human body. The results could help to improve treatments in space.

“We were very pleased with the high quality of the proposals and the excellent work performed by all the participant teams,” said Javier Ventura-Traveset of ESA’s Education Office. “The collaboration between various ESA departments and ELGRA also proved to be excellent and very helpful to this new program.”

More news on this program and the evolution of the design of the selected teams will be posted on the ESA Education website in the coming months. The flights are scheduled to take place in autumn 2009.

Image Courtesy ESA

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Research Claims Earth Facing Ice Age

Scientists are now making an alarming claim that the earth is on the brink of entering another Ice Age that could last the next 100,000 years.

They believe a 12,000-year warming period is currently winding down.

They say ice cores, ocean sediment cores, the geologic record, and studies of ancient plant and animal populations all demonstrate a regular cyclic pattern of Ice Age patterns, separated by intervening warm interglacials, each lasting about 12,000 years.

Experts point out that most of the long-term climate data collected from various sources also shows a strong correlation with the three astronomical cycles which are together known as the Milankovich cycles.

The three Milankovich cycles include the tilt of the earth, the shape of the earth’s orbit, and the Precession of the Equinoxes, which gradually rotates the direction of the earth’s axis over a period of 26,000 years.

The Milankovich theory of Ice Age causation claims that these three astronomical cycles work together to produce the cycle of cold Ice Age maximums and warm interglacials.

Since the late 1970s, the Milankovich theory has been recognized as the predominant theory to account for Ice Age causation among climate scientists.

However, during the 1970s the famous American astronomer Carl Sagan and other scientists began promoting the theory that “Ëœgreenhouse gasses’ such as carbon dioxide, or CO2, produced by human industries could lead to catastrophic global warming.

Now global warming is accepted as fact by most of the academic establishment, and scientists are encouraging governments to make pivotal changes to prevent its theoretical effects.

The main evidence cited in support of the global warming theory is the famous “Ëœhockey stick’ graph presented by Al Gore in his 2006 film “An Inconvenient Truth.”

The “Ëœhockey stick’ graph shows an acute upward spike in global temperatures that began during the 1970s and continued through the winter of 2006 and 2007.

Yet, this warming trend was interrupted when the winter of 2007 and 2008 delivered the deepest snow cover to the Northern Hemisphere since 1966 and the coldest temperatures since 2001.

Some experts believe the current Northern Hemisphere winter of 2008 and 2009 will probably equal or surpass the previous winter in both snow depth and cold temperatures.

A few researchers claim global warming is flawed because it focuses on evidence from the past one thousand years, while ignoring the evidence from the past million years.

However, some believe the data from paleoclimatology provides an alternative and more credible explanation for the recent global temperature spike, based on the natural cycle of Ice Age maximums and interglacials.

The British journal “Nature” published the results of data derived from glacial ice cores collected at the Russia ‘s Vostok station in Antarctica during the 1990s.

The graph of the Vostok ice core data shows that the Ice Age maximums and the warm interglacials occur within a regular cyclic pattern.

The Vostok data graph also shows that changes in global CO2 levels lag behind global temperature changes by about eight hundred years, which means global temperatures precede or cause global CO2 changes, and not the reverse as claimed by global warming.

In other words, increasing atmospheric CO2 is not causing global temperature to rise; instead the natural cyclic increase in global temperature is causing global CO2 to rise.

Some say the release of CO2 by the warming oceans lags behind the changes in the earth’s temperature.

So global CO2 levels could continue to rise for another eight hundred years after the end of the earth’s current Interglacial warm period. Scientists believe we will be eight hundred years into the coming Ice Age before global CO2 levels begin to drop in response to the increased chilling of the world’s oceans.

The Vostok ice core data graph reveals that global CO2 levels regularly rose and fell in a direct response to the natural cycle of Ice Age minimums and maximums during the past four hundred and twenty thousand years. Within that natural cycle, about every 110,000 years global temperatures, followed by global CO2 levels, have peaked at approximately the same levels that they are at today.

Image Courtesy UPI

Original Source: Gregory F. Fegel / Pravda

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CDC Study: 1 In 200 Children Are Vegetarian

About 1 in 200 young Americans are vegetarians, according to the first government study to provide a nationwide estimate of how many children eat meat.

The new estimate comes from a recent Centers for Disease Control and Prevention study of thousands of Americans in 2007. The study used surveys to gather information about the eating habits of children and teens from about 9,000 parents or guardians.

The survey found that about 367,000 US children are vegetarians ““ meaning their diet consists of no meat. Other surveys suggest the rate could be four to six times that among older teens who have more control over what they eat than young children do.

Many children are prompted to turn down meat after learning about the slaughter process of many animals for food.

“Compassion for animals is the major, major reason,” Richard Schwartz, president of Jewish Vegetarians of North America, an organization with a newsletter mailing list of about 800, told the Associated Press. “When kids find out the things they are eating are living animals – and if they have a pet….”

Nichole Nightingale, 14, was exposed to a YouTube video that showed the graphic details of how chickens are slaughtered for meat. The letter ended with an invitation to visit the Web site of People for the Ethical Treatment of Animals for more information.

This information prompted Nightingale to become a vegan ““ meaning she consumes no animal meat or animal products such as eggs or milk.

“A lot more kids are using the Internet. They’re curious about stuff and trying to become independent and they’re trying to find out who they are,” she said.

Previous studies have shown that vegetarians are more often females from higher-income families.

“Vegetarian doesn’t mean low-calorie,” said Dr. Christopher Bolling, who directs weight management research at Cincinnati Children’s Hospital Medical Center. He said roughly 10 to 15 percent of the overweight kids who come to his medical center’s weight loss program have tried a vegetarian diet at some point before starting the program.

However, vegetarian diets can be very healthy, although typical vegetarian diets miss out on key nutrients such as vitamins B12 and D, iron, calcium mostly obtained from meat.

Experts say this highlights the need for children who want to be vegetarians to discover non-meat options that will still provide them with the proper amount of nutrients.

These options include soybeans, fortified soy milk and nuts, which can be good sources of protein, iron, zinc, calcium and vitamin D.

Dr. David Ludwig of Children’s Hospital Boston, a specialist in pediatric nutrition, told AP that vegetarian diets for children are very feasible, but vegan diets can be much tougher.

“It really requires much more attention to avoid nutrient deficiencies,” Ludwig said.

As children age, the amount of protein needed in their diets continues to increase.

The CDC offers certain alternatives including legumes (dry beans and peas), tofu, nuts and seeds, grains and some fruits and vegetables that include important sources of protein.

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The Carbon Footprint Of Google Searches Revealed

A Harvard University physicist has determined a way to measure the carbon footprint of performing a search on Google.

“A Google search has a definite environmental impact,” said Alex Wissner-Gross, who conducted research on how much power is demanded by a typical search.

He found that a normal search generates about 7g of CO2.

The reason, Wissner-Gross said, is that “Google operates huge data centers around the world that consume a great deal of power.”

Most people who click over to Google don’t even consider that their searches may have a measurable consequence on the environment.

Google is secretive about its energy consumption and carbon footprint. It also refuses to divulge the locations of its data centers. However, with more than 200 million Internet searches estimated globally daily, the electricity consumption and greenhouse gas emissions caused by computers and the Internet is provoking concern, according to a report on Sunday in The Times of London.

The global IT industry generates about 2 percent of global carbon dioxide emissions, or about as much greenhouse gas as the world’s airlines, according to a recent Gartner study.

“Data centers are among the most energy-intensive facilities imaginable,” said Evan Mills, a scientist at the Lawrence Berkeley National Laboratory in California.

A typical phrase search on Google requires information to be sent to servers across the globe, which demands a high amount of energy and generates high levels of CO2.

Wissner-Gross has submitted his research for publication by the US Institute of Electrical and Electronics Engineers and has also set up a Web site aimed at “making websites green.”

Still, Google maintains that it is among the most efficient of all Internet search providers.

“Google are very efficient but their primary concern is to make searches fast and that means they have a lot of extra capacity that burns energy,” he said.

Nicholas Carr, author of The Big Switch, Rewiring the World, has calculated that maintaining a character (known as an avatar) in the Second Life virtual reality game, requires 1,752 kilowatt hours of electricity per year. That is almost as much used by the average Brazilian.

“It’s not an unreasonable comparison,” Liam Newcombe, an expert on data centers at the British Computer Society, told The Times. “It tells us how much energy westerners use on entertainment versus the energy poverty in some countries.”

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Quakes In Yellowstone Stir Fear Of Eruption

A series of seismic activity events in Yellowstone National Park has sparked public concerns that the quakes could lead to a catastrophic eruption from one of the world’s largest volcanoes.

Seismic activity at Yellowstone Lake in Yellowstone National Park increased in late December 2008, according to the Yellowstone Volcano Observatory (YVO), which monitors volcanic and earthquake unrest in the Yellowstone National Park region.

About 900 earthquakes occurred during the period of December 26 through January 8. Five hundred of the earthquakes were reviewed by seismologists, according to YVO.

However, the seismic activity has markedly decreased since January 8, 2009. Earthquake swarms within the Yellowstone caldera are typical, with magnitudes occasionally ranging above 4.0. The largest earthquake in the recent swarm was a magnitude 3.9.

“All earthquakes with magnitudes greater than 2.0 have now been reviewed by YVO seismologists,” said YVO. “It is possible that the swarm has ended, although a return of activity may occur as previous Yellowstone swarms of this size have lasted for tens of days to many weeks.”

But to outside observers, the quakes are a sign of danger to come.

“To those of us who have been following these events, we know that something is brewing, especially considering that Yellowstone is over 40,000 years overdue for a major eruption,” warned a posting on the online disaster forum Armageddononline.org.

Another Web site, which has been shut down, carried the U.S. Geological Survey logo and made false claims of a “Yellowstone Warning” urging people to leave the National Park for 100 miles around the volcano caldera “because of the danger in poisonous gasses that can escape from the hundreds of recent earthquakes.”

Yellowstone spokesman Al Nash said the site was misleading.

“A casual observer would be led to believe that was an official source,” said Nash.

In the ancient history of the park, the volcano has erupted 1,000 times more powerfully than the 1980 blast at Mount St. Helens, hurling ash as far away as Louisiana.

“Statistically, it would be surprising to see an eruption the next hundred years,” said Jake Lowenstern, the Menlo Park, Calif.-based scientist in charge of YVO.

Much more likely, he said, would be a hydrothermal explosion in which underground water encounters a hot spot and blasts through the surface.

The Observatory maintains that the volcano’s alert level has not changed from “normal.”

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Scientists Discover Rare, Venomous Shrew-like Mammal

Researchers have released new footage of one of the world’s rarest mammals ““ a giant shrew-like creature that packs a venomous bite.

Discovered in the Caribbean, the Hispaniolan solenodon resembles a large shrew with a long thin snout.

The insect-eating mammal can be found only in the Dominican Republic and Haiti, researchers say.

“My colleagues were excited and thrilled when they found it in the trap,” said Dr Richard Young, from Durrell Wildlife Conservation Trust.
“But despite a month’s worth of trapping effort, they only ever caught a single individual.”

Researchers studied the mammal by taking samples of its DNA and other information before releasing it back into its natural habitat.
The mammal has special teeth that allow it to deliver venom through its bite. It is unclear whether the “dental venom delivery systems” are for self-defense or predatory means.

Reports of the footage, taken in the summer of 2008 have already spurred the call for added conservation efforts for the mysterious mammal.
Still, little is known about its ecology, its behavior, its population status or its genetics, Young said, which makes conservation efforts hard to determine.

The Hispaniolan solenodon is one of the creatures highlighted by the Zoological Society of London’s (ZSL) Edge of Existence programme, which focuses its efforts on conservation plans for animals that are both endangered and evolutionarily distinctive.

“It is an amazing creature – it is one of the most evolutionary distinct mammals in the world,” Dr Sam Turvey, a ZSL researcher involved with the program, told BBC News.

“Along with the other species of solenodon, which is found in Cuba (Solenodon cubanus), it is the only living mammal that can actually inject venom into their prey through specialized teeth,” he said.

“The fossil record shows that some other now-extinct mammal groups also had so-called dental venom delivery systems. So this might have been a more general ancient mammalian characteristic that has been lost in most modern mammals, and is only retained in a couple of very ancient lineages.”

Turvey said his team had previously considered the mammal to be extinct, but were surprised upon discovering it in the wild.

“They are still incredibly vulnerable and fragile. So it is really important to get back out there to work how these animals are surviving,” said Turvey.

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Image:Wikipedia

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Preterm Births Increase 36 Percent Since early 1980s

Late preterm infants drive the increase

New government statistics confirm that the decades-long rise in the United States preterm birth rate continues, putting more infants than ever at increased risk of death and disability.

Nearly 543,000 babies were born too soon in 2006, according to the National Center for Health Statistics, which today released “Births: Final data for 2006,” National Vital Statistics Reports; Vol. 57, No. 7. The nation’s preterm birth rate (birth before 37 completed weeks gestation) rose to 12.8 percent in 2006 — that’s a 36 percent increase since the early 1980s.

The report attributed much of the increase to the growing number of late preterm infants (those born at 34 to 36 weeks gestation), which increased 25 percent since 1990. The report also noted an increase in preterm births to Hispanic women, while rates were unchanged for non-Hispanic whites and blacks. However, black women continue to have the highest preterm birth rate, at 18.5 percent.

The preterm birth rate continued to rise despite the fact that multiple births, a known risk factor for preterm birth, have begun to stabilize. The rate of twin births was unchanged in 2005 and 2006, and triplets and higher order multiples declined 5 percent in 2006.

“The health consequences for babies who survive an early birth can be devastating and we know that preterm birth exacts a toll on the entire family ““ emotionally and financially,” said Dr. Jennifer L. Howse, president of the March of Dimes.

“We are committed to raising public awareness about premature birth, and we believe there are concrete steps we can take to solve this problem, including ensuring that all women of childbearing age have access to health insurance and expanding our nation’s investment in research into the causes and strategies to prevent preterm birth,” Dr. Howse continued.

Preterm birth is the leading cause of death in the first month of life and a contributing cause in more than a third of all infant deaths. Babies who survive an early birth face the risk of serious lifelong health problems and even late preterm infants have a greater risk of breathing problems, feeding difficulties, temperature instability (hypothermia), jaundice, delayed brain development and an increased risk of cerebral palsy and mental retardation.

Last month, the March of Dimes issued its first-ever Premature Birth Report Card, which gave the United States a “D” — and not a single “A” to any state — by comparing 2005 preterm birth rates to the national Healthy People 2010 objective of 7.6 percent. The report card is online at www.marchofdimes.com/petition.

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Novel Treatment Extends Life of Boy with Pompe Disease

The life of a Minnesota boy suffering with a rare and serious form of the genetic disorder Pompe disease has been extended after treatment with a drug typically used to suppress the immune system of those with cancer and rheumatoid arthritis.

Rituxan, or rituximab,  is a monoclonal antibody made by Genentech Inc and Biogen Idec.  It consists of genetically engineered immune system molecules, and is used to treat non-Hodgkin’s lymphoma, rheumatoid arthritis and other conditions.

Dr. Nancy Mendelsohn of Children’s Hospitals and Clinics of Minnesota led a team of researchers that devised a novel treatment plan for the boy using Rituxan in combination with the rheumatoid arthritis drug methotrexate and intravenous gamma globulin.  The researchers’ goal was to dampen the boy’s immune response.

“It seems to have worked,” Dr. Mendelsohn told Reuters.

Pompe is an enzyme disease that robs many of its youngest victims of a gene that makes GAA, or alpha-glucosidase, which is required to break down glycogen.  If not broken down, the glycogen, a stored form of sugar, builds up and damages the muscles.  The condition is particularly damaging to the heart and skeletal muscles.

While older patients with Pompe usually respond to enzyme replacement therapy, many infants with the “CRIM negative” form of the disease quickly produce antibodies to the enzyme and rarely live even one year.

However, that has not been the case for Ira Brown of Minneapolis, whose symptoms first appeared at five weeks of age.  

Dismayed by the poor prognosis of infants who develop the disorder, Mendelsohn and her team wanted to try to suppress the child’s immune system, hoping that would allow him to better respond to the enzyme replacement treatment.

At 2-1/2, Brown is now the oldest survivor of the CRIM negative form of Pompe disease after receiving the new treatment.
Mendelsohn is optimistic the treatment will produce a tolerance to enzyme-replacement therapy, so that the Rituxan could ultimately be discontinued.  The treatment is being tried on other children, she said, and may work for other diseases such as hemophilia A and B, Gaucher’s disease and Fabry’s disease.

Mendelsohn’s report about Brown’s case was published Wednesday in the New England Journal of Medicine on Wednesday.  A summary can be viewed here.

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Newest Anti-Clotting Drug Made From Goat’s Milk?

Does your family have a history of blood clots? If you do, the good news is that the newest anti-clotting medication is moving closer to distribution in the US. The interesting and unusual thing about the drug is that that is made from”¦. goat’s milk.

The scientific first, the drug, prepared from the milk of genetically engineered goats received approval from the experts at the Food and Drug Administration. The FDA has announced that the medication is effective and safe.

Named ATryn, the drug is meant to aid those suffering from an unusual hereditary disorder that caused accelerated vulnerability to blood clots.

The medicine’s authorization would be a huge step toward innovative medications made from active organisms genetically altered by scientists. Related drugs could become accessible in the next following years for a variety of problems, including hemophilia.

A Massachusetts biotechnology corporation, GTC Biotherapeutics, created ATryn by shifting around the genes of goats so they would make milk loaded with antithrombin, a protein that in performs like a natural blood thinner.

1 in 5,000 individuals do not make antithrombin, which raises the risk of developing blood clots. These clots can be painful, and if move into the bloodstream, lungs or brain, the results can be deadly. Pregnant women affected with the disorder are more likely to miscarriage or have a stillbirth, due to clots in the placenta.

Karen Janes, who lost her teen daughter Mary Karen from a brain clot connected to the disorder, says the important thing is that the drug is effective, not that it is made from goat’s milk.

“I think this goat thing is just wonderful,” said Janes. “I do want this drug to go through all the rigors of testing by the FDA. But if it can work, and it can save other families from what we went through, I think that’s marvelous.”

The FDA will consider the hazards and benefits of ATryn at a meeting on Friday, and make a proposal to, or not to, approve the medicine.

“It’s the first time we’ve held an advisory committee meeting on any product from a genetically engineered animal,” said FDA spokeswoman Siobhan DeLancey.

If the drug passes the tests, the FDA could call for additional monitoring to ensure that patients’ immune systems avoid creating antibodies in response to the medicine.

“I think this is an important tipping point,” said Geoffrey Cox, chairman of GTC, the drug maker. “The real dramatic thing that is happening here is that we’ve been able to reduce some very clever science to the practical level of producing a drug that’s safe and efficacious. Those things aren’t trivial.”

In the past, antithrombin was manufactured from blood products harvested from human donors. Creating the goat protein could be healthier for humans, stated Dr. Stephan Moll, a hematologist at the University of North Carolina. It would guarantee a continual supply and lessen worries about infection.

“It’s a new mechanism by which drugs could be produced in pretty large volume in the future,” said Moll.

ATryn is already on the market in Europe.

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FDA Approved Drugs Restore Sensitivity to Appetite Suppressant Fat Hormone

A new study in the January 7th issue of Cell Metabolism, a Cell Press publication, helps to explain why obese people and animals fail to respond to leptin, a hormone produced by fat that signals the brain to stop eating. What’s more, they show that two FDA-approved drugs might restore leptin sensitivity, offering a novel treatment for obesity.

” Most importantly, our study is the first success in sensitizing obese mice on a high-fat diet to leptin,” said Umut Ozcan of Harvard Medical School. “If it works in humans, it could treat obesity.”

When leptin was first discovered some 13 years ago, it led to great excitement in the field, Ozcan said. Studies showed that leptin administered to obese mice that lacked the hormone lost weight. The buzz over leptin’s potential as an obesity therapy soon waned, however, because obese animals and people don’t respond to the hormone. Efforts to find drugs that act as leptin sensitizers over the years have also failed.

However, the underlying reason why obese individuals become leptin resistant in the first place remained open to question. The new study by Ozcan’s team has shed some light on that issue.

Recent studies by him and his colleagues showed that a condition known as endoplasmic reticulum (ER) stress in peripheral organs plays an important role in obesity-induced insulin resistance and type 2 diabetes. Ozcan describes ERs as protein factories within cells. Within those cellular components, molecular chaperones, which serve as the factory workers, facilitate the folding and transport of proteins. When the chaperones can’t keep up, it triggers a stress response known as the unfolded protein response (UPR).

Ozcan suspected that ER stress and the UPR response might also lead to leptin resistance in the brain’s hypothalamus. The hypothalamus is the primary brain region that responds to leptin, sending a signal that curbs appetite. Mice engineered to have reduced ER capacity or increased ER stress throughout their bodies do gain more weight on a high-fat diet, according to earlier studies.

Ozcan now reports that obese mice manipulated to have increased ER stress only in the hypothalamus show less response to leptin. The animals are not only more leptin resistant, but they also grow significantly more obese on a high-fat diet.

The question then became whether the animals could be resensitized by treating them with either of two pre-existing drugs (4-Phenyl Butyric Acid [PBA] and Tauroursodeoxycholic acid [TUDCA]) that act as ER stress reducers. And the answer, they report, is yes.

” It was very exciting,” Ozcan said of the discovery. “Normal mice treated with the drugs dropped some weight and quickly rebounded, but the knockout mice [that were genetically predisposed to ER stress in the brain] continued to lose weight. It shows that ER stress relievers are leptin sensitizers.”

That makes PBA and TUDCA the first leptin sensitizers, Ozcan emphasized.

” A leptin-sensitizing agent has not been previously described despite the long-standing efforts in both academia and industry,” he wrote. “The results presented in this study provide evidence that chemical chaperones, particularly the PBA and TUDCA, can be used as leptin-sensitizing agents. When the high safety profiles of PBA, TUDCA, and leptin are taken into consideration, our results may define a novel treatment option for obesity.”

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Drinking Coffee Halves Cancer Risk

A new Japanese study suggests that drinking coffee may reduce a person’s risk of developing oral cancers.

The Japanese consume relatively high amounts of coffee, and Japanese men also experience comparatively high incidences of esophageal cancer. Dr. Toru Naganuma of Tohoku University, Sendai, and his colleagues wanted to examine whether the consumption of coffee provided any protective effects from these cancers.

They analyzed data from the population-based Miyagi Cohort Study in Japan, which included information about diet, including coffee consumption.  Of the more than 38,000 participants, all of which were aged 40 to 64 years with no prior history of cancer, 157 cases of cancer of the mouth, pharynx and esophagus occurred during 13 years of follow up.

The researchers found that those who drank one or more daily cups of coffee had a 50 percent reduced risk of these cancers compared with those who did not drink coffee.  Furthermore, the reduction in risk applied to all participants, including those who were current drinkers and/or smokers at the start of the study and were therefore at higher risk for these cancers.

“We had not expected that we could observe such a substantial inverse association with coffee consumption and the risk of these cancers, and the inverse association in high-risk groups for these cancers as well,” Naganuma said in an interview with Reuters.

“Although cessation of alcohol consumption and cigarette smoking is currently the best known way to help reduce the risk of developing these cancers, coffee could be a preventive factor in both low-risk and high-risk populations,” the researchers wrote in a report about their study, published in the American Journal of Epidemiology, December 15, 2008.

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3-D Model Of SARS-Causing Virus Reveals New Information

Scientists have developed a three-dimensional model of a virus that causes SARS, which they believe will assist future efforts to battle the disease.

Dutch researchers created the model using a hepatitis coronavirus from mice, they reported in the Jan. 13 issue of the journal Proceedings of the National Academy of Sciences.

“I think we can translate what we found for this virus to the SARS virus,” Berend Jan Bosch, a virologist at Utrecht University who worked on the study, told Reuters.

“If you are going to study the SARS virus you will basically find the same features.”

Coronaviruses are enveloped viruses containing the largest reported RNA genomes, which are known to cause hepatitis C, influenza, and SARS. They primarily infect the upper respiratory and gastrointestinal tract of animals and birds.

There are about five known forms of coronaviruses that infect humans. They are considered to be a significant percentage of all common colds in human adults.

Bosch and his colleagues used 3-D electron microscopy to photograph frozen samples of the virus. The outer layer of the virus appeared to be thicker than expected, researchers said. The virus uses the layer to stick to healthy cells to spread.

“Because we take so many pictures from different angles, we could combine the images to recreate the virus in 3D,” Bosch said.

“It is a broader understanding of the architecture of coronaviruses,” he said. “It is really fundamental knowledge.”

Scientists hope their findings will help them gain a better understanding of the deadly SARS outbreak in China in 2002 that killed some 800 people worldwide ad cost as much as $100 billion. The disease was ultimately kept under control after travel restrictions and quarantines were applied.

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There Are New Findings Shed Light on Why Smokers Struggle to Quit

Just seeing someone smoke can trigger smokers to abandon their nascent efforts to kick the habit, according to new research conducted at Duke University Medical Center.

Brain scans taken during normal smoking activity and 24 hours after quitting show there is a marked increase in a particular kind of brain activity when quitters see photographs of people smoking.

The study, which appears online in Psychopharmacology, sheds important light on why it’s so hard for people to quit smoking, and why they relapse so quickly, explains Joseph McClernon, an associate professor in the department of psychiatry and behavioral sciences at Duke University Medical Center.

“Only five percent of unaided quit attempts result in successful abstinence,” says McClernon. “Most smokers who try to quit return to smoking again. We are trying to understand how that process works in the brain, and this research brings us one step closer.”

The Duke researchers used a brain-imaging tool called functional MRI to visualize changes in brain activity that occurs when smokers quit. The smokers were scanned once before quitting and again 24 hours after they quit. Each time they were scanned while being shown photographs of people smoking.

“Quitting smoking dramatically increased brain activity in response to seeing the smoking cues,” says McClernon, “which seems to indicate that quitting smoking is actually sensitizing the brain to these smoking cues.”

Even more surprising, he adds, is the area of the brain that was activated by the cues. “We saw activation in the dorsal striatum, an area involved in learning habits or things we do by rote, like riding a bike or brushing our teeth. Our research shows us that when smokers encounter these cues after quitting, it activates the area of the brain responsible for automatic responses. That means quitting smoking may not be a matter of conscious control. So, if we’re really going to help people quit, this emphasizes the need to do more than tell people to resist temptation. We also have to help them break that habitual response.”

New treatment options at Duke are aiming to do just that. One area of research is focusing on the use of a nicotine patch prior to quitting smoking.

In previously published research, Jed Rose, Director of the Duke Center for Nicotine and Smoking Cessation Research and co-author of this paper as well, showed that wearing the patch and smoking a cigarette with no nicotine proved successful at breaking the learned behavior. “The smoking behavior is not reinforced because the act of smoking is not leading them to get the nicotine,” Rose said. “Doing this before people actually quit helps them break the habit so they start smoking less. We’re seeing people quit longer this way.”

——

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Duke University Medical Center

Entomologists Warn Of ‘Insect-Based’ Biological Terrorism

An academic at Wyoming University has warned that it would be “relatively easy” for terrorists to launch a devastating attack using swarms of insects to spread a deadly disease.

“Rift Valley Fever or other diseases could be transported into a country by a terrorist with a suitcase,” said Jeffrey Lockwood, a professor of entomology and author of Six-legged Soldiers: Using Insects as Weapons of War.

“I think a small terrorist cell could very easily develop an insect-based weapon,” he added.

Lockwood believes it would probably be much easier than developing a nuclear or chemical weapon since the “raw material is in the back yard.”

He said it would be a relatively easy and simple process.

He warned that with a few hundred dollars and a plane ticket a terrorist could have a pretty good stab at it.

He suggests that governments develop a robust “pest management infrastructure that’s able to absorb and respond to an introduction” of infected insects.

He said trying to stop everything coming in at the border would not work.

The World Health Organization lists Rift Valley Fever as an east African disease that “can cause severe disease in both animals and humans, leading to high rates of disease and death.

“However, the vast majority of human infections result from direct or indirect contact with the blood or organs of infected animals,” WHO said.

The disease was first reported among livestock in Kenya around 1915, but the virus was not isolated until 1931.

Approximately 1% of human sufferers die of the disease.

Image Caption: This transmission electron micrograph (TEM) depicted a highly magnified view of a tissue that had been infected with Rift Valley fever (RVF) virus. CDC

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New Generation Golf Clubs Linked To Hearing Loss

Doctors are warning patients who use new titanium drivers that they should use earplugs to protect against hearing loss.

New generation titanium drivers are becoming more popular because they add distance to golfers’ strokes. But doctors say the ultra-thin faced clubs can create a “sonic boom” sound when it strikes the ball.

This sound may be loud enough to damage hearing, M.A. Buchanan, an ear nose and throat specialist, and colleagues at the Norfolk and Norwich University Hospital reported in the British Medical Journal.

Researchers analyzed the case of a 55-year-old man who had entered the outpatient clinic with tinnitus ““ ringing in the ears ““ and reduced hearing in his right ear.

The man had been playing golf with a King Cobra LD titanium club three times a week for 18 months, and he told doctors that the sound of the club face striking the ball was similar to the sound of a gun going off.

After MRI scans of the man’s middle and inner ear, doctors concluded that the hearing loss was linked to the loud noise coming from the golf club.

Researchers found other interesting reviews of the King Cobra LD club on the Internet.

“Drives my mates crazy with that distinctive loud “ËœBANG’ sound. Have never heard another club that makes so distinctive a sound. It can be heard all over the course, it is mad!!” one golfer wrote.

“This is not so much a ting but a sonic boom which resonates across the course!” said another.

Researchers use something known as the coefficient of restitution (COR) to measure of the elasticity or efficiency of energy transfer between a golf ball and club head.

“The United States Golf Association, in conjunction with the Royal and Ancient, St Andrews, Scotland, stipulates that the upper limit of COR for a golf club in competition use is 0.83.3 This means that a club head striking a ball at 100 miles per hour (mph) will cause the ball to travel at 83 mph. Thinner faced titanium clubs, such as the King Cobra LD, have a greater COR and deform on impact more easily, the so called trampoline effect, not only propelling the ball further, but resulting in a louder noise.”

The doctors asked a professional golfer to participate in the study by hitting three two-piece golf balls with six thin-faced titanium golf drivers and six standard thicker faced stainless steel golf drivers.

They used a modular precision sound level meter to determine the level of sound resonating from each club.

They found that each of the thin faced clubs were louder than the traditional stainless steel clubs. However, they noted, the King Cobra LD was not the loudest one of the bunch.

“The study presents anecdotal evidence that caution should be exercised by golfers who play regularly with thin faced titanium drivers to avoid damage to their hearing,” researchers concluded.

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Adult-Onset Diabetes Slows Mental Functioning

Adults with diabetes experience a slowdown in several types of mental processing, which appears early in the disease and persists into old age, according to new research. Given the sharp rise in new cases of diabetes, this finding means that more adults may soon be living with mild but lasting deficits in their thought processes.

A full analysis appears in the January issue of Neuropsychology, which is published by the American Psychological Association.

Researchers at Canada’s University of Alberta analyzed a cross-section of adults with and without adult-onset Type 2 diabetes, all followed in the Victoria Longitudinal Study. At three-year intervals, this study tracks three independent samples of initially healthy older adults to assess biomedical, health, cognitive and neurocognitive aspects of aging. The Neuropsychology study involved 41 adults with diabetes and 424 adults in good health, between ages 53 and 90.

The research confirmed previous reports that diabetes impairs cognition and added two important findings. First, it teased out the specific domains hurt by diabetes. Second, it revealed that the performance gap was not worse in the older group. Thus, the reductions in executive function and processing speed seem to begin earlier in the disease.

Healthy adults performed significantly better than adults with diabetes on two of the five domains tested: executive functioning, with significant differences across four different tests, and speed, with significant differences or trends across five different tests. There were no significant differences on tests of episodic and semantic memory, verbal fluency, reaction time and perceptual speed.

When researchers divided participants into young-old and old-old, with age 70 as the cutoff, they found the same pattern of cognitive differences between young-old and old-old in the diabetes and control groups. Thus, the researchers concluded, the diabetes-linked cognitive deficits appear early and remain stable.

“Speed and executive functioning are thought to be among the major components of cognitive health,” says co-author Roger Dixon, PhD. With Type 2 diabetes a growing concern among adults of all ages, but especially those above age 30, Dixon says that public health programs could check the cognitive status of people with more advanced or severe cases; ensure that diet and medications are effectively employed in all early diagnosed cases; and enact possible cognitive monitoring or training programs for people with diabetes. According to the U.S. Centers for Disease Control and Prevention, new cases of diabetes nearly doubled in the past decade, with nearly one new case for every 100 adults between the years 2005 and 2007.

The normal age-related slowing of thought processes could be exacerbated by diseases such as Type 2 diabetes, says Dixon. But, he continues, “There could be some ways to compensate for these declines, at least early and with proper management.” The level of impairment detected, he adds, should not make it hard for people to manage their condition.

Diabetes is a known risk factor for late-life neurodegenerative diseases such as Alzheimer’s. Although the deficits detected in the current sample were not clinically significant, they appear (according to subsequent research by the authors) to foreshadow additional deficits. Only further study would reveal whether it’s possible to “connect the dots” between mild early deficits in speed and executive function, and later signs of a progressive cognitive impairment.

Article: “Exploring Effects of Type 2 Diabetes on Cognitive Functioning in Older Adults,” Sophie E. Yeung, PhD, Ashley L. Fischer, PhD, and Roger A. Dixon, PhD, University of Alberta; Neuropsychology, Vol. 23, No. 1.

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New Nano Device Aids Drug Dispersal

Researchers found a more accurate way to deliver cancer drugs, by harnessing the power of gold nanoparticles.

They wrote in the journal ACS Nano that the system could release a number of drugs in a specific part of the body at desired times.

The device relies on the fact that different particles melt when exposed to different levels of infrared light. Therefore, different drugs on the particles could be released in a controlled way.

Researchers say delivering drugs directly to a specific site within the body is beneficial because you can use relatively toxic drugs without causing widespread damage to healthy tissue.

A number of trials are using nanoparticles to take drugs directly to the site of a tumor.

Doctors shine near-infrared light on the site, penetrating the skin to reach the tumor. It causes the particles to heat up and release the drugs contained inside.

The device developed by the MIT team involves two differently shaped nanoparticles which have separate melting points, meaning complex HIV/Aids drugs can be released in a controlled way at appropriate intervals.

“Just by controlling the infrared wavelength, we can choose the release time,” said lead author Andy Wijaya.

Kat Arney, of Cancer Research UK, said that nanoparticles were a “hot topic in cancer research because they can directly target tumors to deliver a payload of drugs”.

“This new technique is clever because it means a number of different drugs can be released. But although it’s exciting the work is still at an early stage and is not yet ready to be used in patients.”

Image 2: The top image shows a mixture of gold nanoparticles. The longer particles are called nanobones, and the smaller are nanocapsules. Bottom left: After the nanoparticles are hit with 800 nanometer wavelength infrared light, the nanocapsules melt and release their payload. Nanobones remain intact. Right: After the nanoparticles are hit with 1100 nanometer wavelength infrared light, the nanobones melt and release their payload. Nanocapsules remain intact. Image / Andy Wijaya

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LA funeral held for Majel Roddenberry

About 300 people, some in Star Trek costumes, attended the Los Angeles funeral of Majel Barrett Roddenberry on Sunday, E! News reported.

The woman known as the First Lady of Star Trek died Dec. 18, reportedly from leukemia, at the age of 76. She was married to late Star Trek creator Gene Roddenberry from 1969 until he died in 1991 at the age of 70. She played Nurse Christina Chapel on the original Star Trek TV series and also lent her voice to the USS Enterprise’s computer in various other Trek projects.

Majel Barrett Roddenberry was buried at Forest Lawn Hollywood Hills cemetery during a public service attended by family, friends and Star Trek fans. Among the mourners were original Trek stars Walter Koenig, Nichelle Nichols and George Takei, E! News said.

Infertile Couples More Likely To Suffer Depression, Anxiety

A new Italian study finds that anxiety, depression and certain other mental health conditions are more prevalent among infertile couples than those who are not infertile.

The small study, led by Dr. Chiara Sbaragli of the University of Siena School of Medicine in Italy, suggests that mental health screenings might be beneficial to those being treated for infertility, researchers say.

Although most of the 81 infertile couples involved in the study did not experience any of the psychiatric conditions the researchers looked for, they did have higher rates of certain disorders when compared with 70 couples that were not infertile.

The biggest discrepancy was in the diagnosis of “adjustment disorder,” something that refers to symptoms of depression and anxiety in response to an identifiable cause.  In this case, that cause was likely patients’ infertility. 

The researchers found the discrepancy was particular notable among women.  Among infertile women, 28 percent had an adjustment disorder marked by anxiety and depression, compared with only 3 percent of fertile women. Furthermore, 18 percent of infertile women currently had binge-eating disorder, while none of the fertile women did, reported the researchers.

Among men, infertility patients had higher rates of “subclinical” obsessive-compulsive disorder and social phobia.  “Subclinical” means signs and symptoms of anxiety disorders were present, but not in a degree to which a diagnosis could be made.

The researchers said it wasn’t possible to determine whether these mental health conditions were the result of, rather than a contributing factor to, the patients’ infertility. In the case of adjustment disorders, it’s likely that patients’ symptoms were a response to their fertility problems, Sbaragli and her colleagues wrote in a report about the study.

However, these symptoms could perhaps make it harder for patients to recover from infertility, the researchers added.  Indeed, the effects of anxiety and on the body’s nervous system, for example, could affect reproductive function.

If larger studies confirm the current findings, doctors may choose to  routinely screen infertile patients for anxiety disorders, depression and eating disorders, the researchers said.

The study was published in the December 2008 journal Fertility and Sterility.  

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New Chinese Solar Plant Could Become World’s Largest

China Technology Development Group Corp and privately held Qinghai New Energy Group announced Friday their plans to construct a solar power plant in northwestern China that could become the world’s largest photovoltaic solar project.

Shares of China Technology Development rose 29 percent to $2.61 on Nasdaq following the announcement.  Shares of most solar power companies were also up on the news, bolstered by higher oil prices and an upswing in the broader market.

Construction of the 30-megawatt solar power station in China’s Qaidam Basin will begin this year with an initial investment of $150 million, the joint statement said.

The project will combine thin-film and traditional silicon-based technologies that convert the sun’s rays into electricity.  While the companies did not disclose timelines for the project, they said the plant will eventually produce 1 gigawatt of power.

Pavel Molchanov, an analyst with Raymond James, said the largest photovoltaic solar project announced to date is the 550 MW  collaboration between thin-film company OptiSolar and PG&E Corp., a California utility.

“The initial phase of the project is … itself one of the largest solar farms ever announced in China,” wrote Molchanov in a client note.

The Chinese government is starting to offer additional incentives for solar power projects, he noted.

“While PV demand has been historically driven by a small number of key countries, the demand profile should become more geographically diverse over time.”

The news offered investors in solar companies a welcome reprieve.  Shares of such companies have been badly bruised in recent weeks due to a lack of funding for new projects, declining prices on solar panels and plunging oil prices, which have dampened appetite for investments in renewable energy.

Friday’s announcement ignited a rally across the entire solar power industry, with shares of U.S. solar equipment maker GT Solar International Inc. up 24.6 percent to $3.60, and shares of Chinese solar cell maker JA Solar Holdings Co Ltd up 12.6 percent to $4.92.  Shares of  U.S. cell maker SunPower Corp rose 12.8 percent to $41.74, while China’s Yingli Green Energy Holding Co Ltd was up 13.1 percent to $6.90.

A spike in the price of crude oil to over $46 a barrel, along with a 2 percent rise in Wall Street’s main indexes, also bolstered solar stocks, Molchanov told Reuters.

The rally came despite a downward revision of earnings estimates of Evergreen Solar Inc, GT Solar, Canadian Solar Inc, LDK Solar Co Ltd and Renesola Ltd. by Piper Jaffray analyst Jesse Pichel.

“We cautiously assume Q1 will be the industry shipment trough,” Pichel wrote. 

Shares of solar “stocks could trade higher in the next 12 months depending on credit and the extent renewables play in the Obama recovery package,” he added.

Image Caption: Solar array at Nellis Air Force Base. These panels track the sun in one axis. Courtesy USAF

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New Congenital Neutropenia Syndrome and Causative Gene Mutation

A team of scientists has discovered a new syndrome associated with severe congenital neutropenia (SCN), a rare disorder in which children lack sufficient infection-fighting white cells, and identified the genetic cause of the syndrome: mutations in the gene Glucose-6-phosphatase, catalytic subunit 3 (G6PC3). The findings, which are published in the Jan. 1, 2009 issue of The New England Journal of Medicine, were made by an international team of scientists, composed of 14 researchers from the Medical School of Hannover in Germany and 12 from other research institutions, including the National Center for Biotechnology Information at the National Library of Medicine, National Institutes of Health.

“Our discovery will help facilitate genetic diagnosis in this newly defined group of severe congenital neutropenia patients,” said Christoph Klein, M.D., Ph.D., Hannover Medical School, the principal investigator of the study. “Knowledge about the underlying genetic defect is an important first step in developing a targeted therapy.”

The research also identified a novel pathway that is critical in controlling the life and death of immune cells. “This may eventually open new horizons for the development of drugs interfering with that pathway, which is important not only for patients with SCN, but potentially also for patients with other blood disorders,” said Kaan Boztug, M.D., Hannover Medical School, lead author of the study.

Severe congenital neutropenia (SCN) is a rare disorder, with an incidence of less than one in 200,000 births. The disorder is characterized by insufficient quantity of neutrophils, a type of white blood cell important in fighting infection. Children born with SCN suffer from frequent bacterial infections, and until the introduction of treatment with recombinant human granulocyte colony-stimulating factor (GCSF) in the 1990s, about three-fourths of affected children would die before 3 years of age. Treatment with GCSF usually reduces the duration and severity of neutropenia and results in improved clinical outcome and survival. However, SCN patients eventually may develop myelodysplasia or acute myelogenous leukemia.

In recent years, significant progress has been made in identifying the genetic defects that cause SCN, but in many patients, the underlying genetic cause remains unknown. The most common cause of inherited SCN is a heterozygous mutation (where one copy of the gene is mutated and the other is not) in the neutrophil elastase (ELA2) gene. In 2007, Klein’s lab identified another causative mutation in a subgroup of SCN patients: homozygous mutations (where the defect is present in both copies of the gene) in the HAX1 gene.

To conduct the current study, the researchers focused on five children of Turkish descent, four of whom were known to be related; the children did not have identified mutations but had recessive SCN (i.e., the children inherited mutations from both of their parents, who each carried one mutated gene but were themselves unaffected). The children were identified for the study using the SCN International Registry.

A researcher from NCBI analyzed data on the children to look for suspect genes, and determined that the gene of interest was among 258 on chromosome 17. Further positional analysis at NCBI reduced the number of suspect genes to 36. A big break in the research came in early 2007 when a team headed by Janice Chou, Ph.D., at NIH’s National Institute of Child Health and Human Development, published research showing impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking the protein glucose-6-phosphatase, catalytic subunit 3 (also known as G6PC3). The G6PC3 gene happened to be among the 36 genes Klein’s team was examining, and DNA analysis indeed showed that all five study patients had the same mutations in this gene.

The researchers then sequenced the DNA of 104 additional patients from the SCN International Registry with unknown mutations and found G6PC3 mutations in seven. These seven children had different types of G6PC3 mutations than the original five study subjects, but they shared a constellation of clinical symptoms. Eleven of the 12 patients had heart defects or urogenital malformations, and 10 had unusually prominent subcutaneous veins. This grouping of clinical characteristics has not previously been described with SCN and defines a new syndrome associated with G6PC3 mutation.

The study also clarifies the importance of maintaining adequate glucose levels in keeping neutrophils alive and ensuring an adequate immune response to infections. The researchers found that insufficient supply of glucose causes neutrophils to undergo stress, and if the body’s stress response is not adequate, the neutrophils will die. This connection between insufficient glucose and cellular stress response may be relevant to other more common diseases, especially those related to glucose disorders and glycogen-storage disorders.

“The study’s findings are important for the care of patients with SCN, and for building an understanding of the diverse genetic causes of this disease,” said David Dale, M.D., University of Washington, who wrote an accompanying editorial on the study in The New England Journal of Medicine. “We do not know yet if patients with mutations in the G6PC pathway are at risk of developing leukemia and if they will need as frequent blood tests as other SCN patients. Knowledge of G6PC3 mutations will also alert physicians to look for cardiac defects in children with severe neutropenia as a clue to making this specific diagnosis.”

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Ethnicity, Socioeconomic Status Linked To Gestational Diabetes

New Australian research finds that some ethnic groups and women with lower socioeconomic status are at higher risk of developing diabetes while pregnant, or gestational diabetes.

The study found that 30 percent of women who develop gestational diabetes will go on to develop type 2 diabetes within the next 7 to 10 years.

“In some groups, the incidence may increase to 50 percent in 5 years,” said Dr. Hidde P. van der Ploeg of the University of Sydney, Australia, in an interview with Reuters.

Dr. van der Ploeg and colleagues reviewed data on nearly a million births in New South Wales, Australia, between 1995 and 2005.  During that time, the incidence of gestational diabetes jumped 45 percent, increasing from 3.0 to 4.4 percent.

The analysis showed that women born in South Asia were roughly four times more likely than women born in Australia to develop gestational diabetes.  Meanwhile, women born in North Africa or Middle East were 2.4 times more likely to develop pregnancy-related diabetes.

Furthermore, women of lower socioeconomic status were 54 to 74 percent more likely to develop diabetes while pregnant that women in the highest socioeconomic status.  

Increased age was also a significant risk factor, with those over 40 experiencing a six-fold increase of gestational diabetes compared to women in their 20s.

The researchers said that pregnancy-related diabetes is an important risk factor for type 2 diabetes, and ethnicity and socioeconomic status appear to significantly influence the risk of gestational diabetes.

“Cultural specific interventions should be developed to prevent the development of type 2 diabetes in these women at high risk,” said van der Ploeg, “

The study was published in Diabetes Care, December 2008. 

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Male Gene May Control Offspring’s Gender

UK researcher Corry Gellatly believes he has a new explanation for how the human race keeps a balance of males and females.

The research scientist from Newcastle University proposes that a gene determines whether a man will father more sons or daughters. 

According to Gellatly, when the female population is low, women have a better chance of finding a mate, which makes them more likely to pass the gene for fathering daughters to their children.  When men are scarce, they also have a better chance of finding a mate and passing along the gene for more sons to their offspring.

“It’s kind of a counterbalancing mechanism,” Gellatly told Reuters. “You can’t get a population that becomes too skewed toward males or too skewed toward females.”

At the end of each world war, the ratio of male to female births jumped in countries involved in the fighting.  Many hypotheses have been made to explain why.  One says that returning soldiers have extra sex with their partners, leading to fertilization earlier in the menstrual cycle which could lead to more male births. 

Another hypothesis says that larger males are more likely to survive battles, and to have male offspring.

Gellatly devised his hypothesis after sorting through 927 family trees from North America and Europe.

The researcher suggests that men carry a gene controlling their ratio of X to Y sperm.

Gellatly made a computer model to simulate how the gene would work over 500 generations, and studied whether offspring sex ratios in real family trees could support his idea.

Both experiments supported his hypothesis.

Gellatly believes the gene is very ancient, and is probably carried by any species that produces sexually.  He also believes the gene comes in twos in a male (X) and female (Y) version with three combinations of the pair:  XX to produce more male sperm, YY to produce more female sperm, and XY to remain neutral.

“The structure of the proposed gene is essentially very basic, and its function is simply to say ‘produce more boys’ or ‘produce more girls,'” Gellatly added.

Gellatly’s theory explains why male births increased after the world wars.  Families with many sons are more likely to have surviving male children who can pass along genes.  Families with fewer male offspring would be less to likely to have sons who survived the wars.

Academic paper: Trends in Population Sex Ratios May be Explained by Changes in the Frequencies of Polymorphic Alleles of a Sex Ratio Gene. Corry Gellatly. Published in: Evolutionary Biology, DOI 10.1007/s11692-008-9046-3

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Migraine Sufferers Report Stroke Warning Sign

People who regularly suffer from migraines are more apt to have a headache before a stroke, according to new research by Italian scientists.

The report is published in the current issue of the journal Headache.

Lead investigator Dr. Paola Sarchielli said, “Headache is a common clinical symptom preceding or accompanying stroke, and migraine patients have a greater probability of complaining of headache, often with migraine-like features, before and during acute stroke than non-migraineur patients.”

Sarchielli and her research team from the University of Perugia said there is limited information available on the characteristics of headaches associated with ischemia.

Researchers analyzed 146 ischemic stroke patients, 70 who had a lifetime history of migraine and 76 who did not.

Ischemic stroke, the most common type of stroke, stems from a blockage of a vessel in the brain.

The blockage stops the supply of blood and the supply of oxygen to surrounding brain tissue.

Eighty percent of the migraine patients report a headache in the 24 hours before their stroke, compared with 20 percent of those without migraine.

This “suggests that cerebral ischemia lowers the threshold for head pain more easily in these ‘susceptible’ patients,” the researchers wrote.

“The more frequent involvement of brainstem in migraineur patients with ischemic infarction supports the hypothesis that vascular events preceding the clinical stroke…can cause a dysfunction of this structure, which may be more predisposed to be abnormally activated,” concluded Sarchielli.

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Despite winter, ‘striving for 5’ possible

The produce section may be a bit skimpy, but it is still possible to strive for five servings of fruits and vegetables a day, a U.S. expert suggests.

Dr. Jo Ann Carson, a professor of clinical nutrition at the University of Texas Southwestern Medical Center in Dallas, says the solution lies in choosing as much fresh seasonal produce as possible and adding frozen and canned fruits and vegetables.

Frozen fruits and vegetables often contain nearly as many nutrients as fresh produce because they have been picked, frozen and packaged at their peak, Carson says. In fact, some canned vegetables, including pumpkin, provide more vitamins per serving than their fresh counterparts.

The key, is to watch the sugar and sodium content, because canned produce can be higher in both, Carson says in a statement.

A good principle is to look for fruit without added sugar or syrups and vegetables without extra butter, salt or cream sauces.

Grape Seed Extract Causes Leukemia Cell Suicide

Leukemia cells are no match for grape seed extract, according to a team of researchers from the University of Kentucky.

Their recent finding, published in the January issue of Clinical Cancer Research, suggests that grape seed extract is effective ““ killing 76 percent of all leukemia cells that were exposed to the extract.

Xianglin Shi, professor in the Graduate Center for Toxicology at the University of Kentucky, led a team of researchers who sought to study the extract’s activity in hematological cancers. Previous research had shown that grape seed extract was effective against several laboratory cancer cells such as skin, breast and colon

One powerful antioxidant found in grape seed extract is resveratrol, which is known to have anti-cancer properties, as well as positive effect on the heart.

“These results could have implications for the incorporation of agents such as grape seed extract into prevention or treatment of hematological malignancies and possibly other cancers,” said Shi.

“What everyone seeks is an agent that has an effect on cancer cells but leaves normal cells alone, and this shows that grape seed extract fits into this category.”

Shi and his colleagues have been studying chemicals known as proanthocyanidins in fruits that prevent cancer growth. Shi has found that apple peel extract contains these flavonoids, which have antioxidant activity, and which cause apoptosis in several cancer cell lines but not in normal cells.

“This is a natural compound that appears to have relatively important properties,” Shi said.

Additionally, the team discovered a natural method of pushing the cancer cells to commit suicide by using higher doses of the extract. The extract activates a protein called JNK, which causes the natural cell suicide to occur.

While the study could hold promising benefits in the future, scientists said it’s too early to suggest that people increase their grape consumption in order to fight their risk of cancer.

“This is very promising research, but it is too early to say this is chemo-protective,” Shi said.

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Study Questions Effectiveness Of Teen Virginity Pledges

A new study released today by John Hopkins Bloomberg School of Public Health finds that teens who make a pledge of abstinence until they marry are just as likely to engage in premarital sex as those who don’t. Furthermore, those making a “virginity pledge” are substantially less likely to use condoms and other birth control methods.

The study is based on a new analysis of data from a large federal survey. It found that more 50 percent of young people became sexually active before marriage, regardless of whether they had made a pledge of abstinence. 

However, the percentage of those who took precautions against pregnancy or sexually transmitted diseases (STDs) was 10 points lower for those who made the pledge than for those who did not.

“Taking a pledge doesn’t seem to make any difference at all in any sexual behavior,” wrote Janet E. Rosenbaum, the study’s lead author.

“But it does seem to make a difference in condom use and other forms of birth control that is quite striking.”

The study is only the latest to raise questions about the effectiveness of abstinence programs, including those that involve students publicly declaring their intention to remain virgins. However, the new analysis extends beyond earlier studies by focusing on teenagers with similar values about sex and other issues prior to making the abstinence pledge.

“Previous studies would compare a mixture of apples and oranges,” said Rosenbaum.

“I tried to pull out the apples and compare only the apples to other apples.”

The findings have restarted the debate about the effectiveness of abstinence-based sexual education. They come just as Congress is set to reconsider the more than $176 million in annual funding for such programs.

“This study again raises the issue of why the federal government is continuing to invest in abstinence-only programs,” Sarah Brown of the National Campaign to Prevent Teen and Unplanned Pregnancy told the Washington Post.

“What have we gained if we only encourage young people to delay sex until they are older, but then when they do become sexually active — and most do well before marriage — they don’t protect themselves or their partners?”

Supporters of such programs dismissed the study as faulty, and claim that true abstinence programs go much further than simply asking teens to make one-time pledges.

“It is remarkable that an author who employs rigorous research methodology would then compromise those standards by making wild, ideologically tainted and inaccurate analysis regarding the content of abstinence education programs,” Valerie Huber of the National Abstinence Education Association told the Washington Post.

In the current study, Rosenbaum looked at data collected by the federal government’s National Longitudinal Study of Adolescent Health.  The survey collected detailed information from roughly 11,000 students in grades seven through 12 in 1995, 1996 and 2001.

And while researchers have analyzed the survey data before, Rosenbaum’s study is the first to use a more stringent way to account for other factors that could influence the teenagers’ behavior, such as their sexual attitudes before making the pledge.

Rosenbaum centered the study on roughly 3,400 students who had not had sex or who had made a virginity pledge in 1995. She compared 289 students who were on average 17 years old in 1996 when they made a virginity pledge, with 645 who did not make a pledge but were similar in other ways. These similarities were based on 100 variables such as the youths’ sexual attitudes and their parents’ and friends’ attitudes about sex and birth control.

“This study came about because somebody who decides to take a virginity pledge tends to be different from the average American teenager. The pledgers tend to be more religious. They tend to be more conservative. They tend to be less positive about sex. There are some striking differences,” Rosenbaum said.

“So comparing pledgers to all non-pledgers doesn’t make a lot of sense.”

By 2001, 82 percent of those who had taken a virginity pledge had gone back on their promise, and there was no significant difference in the percentage of students in either group who had engaged in sexual activity.  This included vaginal intercourse or giving or receiving oral sex.  Furthermore, there were no differences seen at the age at which the teen first had sex, or the number of partners.  

Rosenbaum found that more than half of both groups had engaged in various types of sexual activity, and had an average of three sexual partners. By the age of 21, they had engaged in sex for the first time, regardless of marital status.

“It seems that pledgers aren’t really internalizing the pledge,” Rosenbaum said.

“Participating in a program doesn’t appear to be motivating them to change their behavior. It seems like abstinence has to come from an individual conviction rather than participating in a program.”

Rosenbaum found no difference in the rate of STDs in the two groups, but the percentage of students who said they used condoms was roughly 10 points lower among those who had made the virginity pledge, and they were 6 points less likely to have used any form of contraception at all.

For instance, nearly one in four of those who had pledged abstinence reported that they always used a condom, compared with about 34 percent of those who had not made the pledge.

Rosenbaum said the difference in the two groups is due to what the youths learn about condom use in abstinence programs.

“There’s been a lot of work that has found that teenagers who take part in abstinence-only education have more negative views about condoms,” she said.

“They tend not to give accurate information about condoms and birth control.”

However, Huber disagreed.

“Abstinence education programs provide accurate information on the level of protection offered through the typical use of condoms and contraception,” she said.

“Students understand that while condoms may reduce the risk of infection and/or pregnancy, they do not remove the risk.”

Rosenbaum’s report appears in the January issue of the journal Pediatrics.

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Doctors Study New Methods Of Preventing Lymphedema

Hospitals in many states nationwide are looking into new simple methods of reducing breast cancer survivors’ risk of developing lymphedema.

Lymphedema is a painful condition that causes a patient’s arm to swell. It is a common side effect of cancer treatments such as surgery and radiation.

“I have ladies tell me the lymphedema is much worse than their cancer because the cancer’s cured,” says Dr. Electra Paskett, an epidemiologist at Ohio State University. Paskett is among those health care professionals who are trying to find the most effective methods of keeping lymphedema at bay.

One of such methods involves elastic sleeves when doing activities that may cause arms to swell.

“The theory is building up muscles in your arm acts as a natural pneumatic pump to move the fluid,” explains Paskett, herself a breast cancer survivor who developed lymphedema.

Since lymphedema is caused by an uncontrolled infection, other limbs, such as the legs, can swell as a result of damaged nodes from other cancers. Former presidential candidate John McCain suffered from facial swelling as a result of melanoma treatment.

But, as it affects an estimated 20 percent to 30 percent of patients who have 10 or more under-the-arm nodes examined, called “axillary lymph node dissections,” the condition is assumed to be most common among breast cancer survivors

In November, researchers reported findings in the Journal of Clinical Oncology that suggests few such women may be aware that they have the condition.

University of Minnesota researchers analyzed records from the huge Iowa Women’s Health study, to cull more than 1,200 patients who’d had breast cancer between 1986 and 2003. Only 8 percent of patients had been diagnosed and another 37 percent of the women suffered persistent lymphedema symptoms, including a swollen arm.

Researchers in the Iowa study found that only 40 percent of the women with swollen arms but no diagnosis had heard of lymphedema and less than 2 percent had sought care for their arm symptoms.

Early treatment of lymphedema is crucial. After 61-year-old Minna Manalo, a nurse practitioner at Georgetown University Hospital’s breast cancer unit, was diagnosed with the condition she underwent what’s called complete decongestive therapy, where a machine massaged fluid from her arm and it then was tightly bandaged to counter swelling. Once her arm shrank, Holman was prescribed a lifelong therapy: A tight elastic sleeve and fingerless glove to wear regularly, especially during her job as an international flight attendant, plus arm exercises to help push out returning fluid.

“I’m trying to stay ahead of the game,” says Holman. “You can’t cure this, but you can manage it.”

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Many ER Workers Carry Highly Resistant Bacteria

Two reports in the Annals of Emergency Medicine say health care workers in emergency departments are often carriers of the methicillin-resistant Staphylococcus aureus, or (MRSA), potentially putting patients at risk.

Dr. Elise O. Lovell from Advocate Christ Medical Center, Oak Lawn, Illinois, said the results of the study, along with the findings of the second report, reinforce concerns that MRSA carriers are an important part of the transmission of MRSA among patients.

The researchers collected nasal swabs from a sample of 105 emergency department staff at their institution. Sixteen subjects (15 percent) tested positive for MRSA, including 12 nurses, 2 physicians, and 2 technicians.

Dr. Lovell said the MRSA positivity rates in surrounding emergency department health care workers was much higher than that found in the general US population, but is similar to rates seen in other studies of non-ED medical personnel.

In the second report, Dr. Brian P. Suffoletto and colleagues from the University of Pittsburgh Department of Emergency Medicine measured the prevalence of Staphylococcus aureus and MRSA in 255 emergency department health care workers.

The researchers reported that just under one third of nasal cultures (31.8 percent) were positive for S. aureus, and the overall prevalence of MRSA 0was 4.3 percent.

The investigators say none of the demographic and exposure characteristics examined were significantly associated with MRSA colonization, but MRSA colonization was restricted to nurses, nursing assistants, and radiology and respiratory technicians.

“The varying prevalence among the different health care workers was unexpected,” Suffoletto said.

Suffoletto said the relationship between MRSA-positive ED personnel and patient transmission is still largely unexplored.

“First we will need to establish if MRSA in ED personnel is transient or persistent. Then we wish to determine the rate of unprotected contacts between ED personnel and patients.”

However, both Lovell and Suffoletto emphasized the importance of using universal infection control practices in the emergency department.

“It’s been demonstrated repeatedly that these hygiene techniques are poorly followed in the ED, yet they represent the best (and simplest) way to minimize the spread of MRSA between our patients and to keep our patients and ourselves safe,” Lovell said.

Dr. John A. Jernigan from the U.S. Centers for Disease Control and Prevention, Atlanta, agreed, saying the findings in these reports may have important implications for infection control practice.

“Better implementation of current recommendations for preventing transmission of MRSA and other multidrug-resistant organisms will likely yield important benefits for both patients and health care personnel.”

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Gold Nanoparticles Deliver Drugs To Treat Cancer, Other Diseases

Using tiny gold particles and infrared light, MIT researchers have developed a drug-delivery system that allows multiple drugs to be released in a controlled fashion.

Such a system could one day be used to provide more control when battling diseases commonly treated with more than one drug, according to the researchers.

“With a lot of diseases, especially cancer and AIDS, you get a synergistic effect with more than one drug,” said Kimberly Hamad-Schifferli, assistant professor of biological and mechanical engineering and senior author of a paper on the work that recently appeared in the journal ACS Nano.

Delivery devices already exist that can release two drugs, but the timing of the release must be built into the device — it cannot be controlled from outside the body. The new system is controlled externally and theoretically could deliver up to three or four drugs.

The new technique takes advantage of the fact that when gold nanoparticles are exposed to infrared light, they melt and release drug payloads attached to their surfaces.

Nanoparticles of different shapes respond to different infrared wavelengths, so “just by controlling the infrared wavelength, we can choose the release time” for each drug, said Andy Wijaya, graduate student in chemical engineering and lead author of the paper.

The team built two different shapes of nanoparticles, which they call “nanobones” and “nanocapsules.” Nanobones melt at light wavelengths of 1,100 nanometers, and nanocapsules at 800 nanometers.

In the ACS Nano study, the researchers tested the particles with a payload of DNA. Each nanoparticle can carry hundreds of strands of DNA, and could also be engineered to transport other types of drugs.

In theory, up to four different-shaped particles could be developed, each releasing its payload at different wavelengths.

Other authors of the paper are Stefan Schaffer and Ivan Pallares, who were National Science Foundation REU (Research Experiences for Undergraduates) summer students through the MIT Department of Biological Engineering in 2008.

Image Caption: The top image shows a mixture of gold nanoparticles. The longer particles are called nanobones, and the smaller are nanocapsules. Bottom left: After the nanoparticles are hit with 800 nanometer wavelength infrared light, the nanocapsules melt and release their payload. Nanobones remain intact. Right: After the nanoparticles are hit with 1100 nanometer wavelength infrared light, the nanobones melt and release their payload. Nanocapsules remain intact. Image / Andy Wijaya

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Weakness In Internet Security Uncovered

Independent security researchers in California and researchers at the Centrum Wiskunde & Informatica (CWI) in the Netherlands, EPFL in Switzerland, and Eindhoven University of Technology (TU/e) in the Netherlands have found a weakness in the Internet digital certificate infrastructure that allows attackers to forge certificates that are fully trusted by all commonly used web browsers. As a result of this weakness it is possible to impersonate secure websites and email servers and to perform virtually undetectable phishing attacks, implying that visiting secure websites is not as safe as it should be and is believed to be. By presenting their results at the 25C3 security congress in Berlin on the 30th of December, the experts hope to increase the adoption of more secure cryptographic standards on the Internet and therewith increase the safety of the internet.

When you visit a website whose URL starts with “https”, a small padlock symbol appears in the browser window. This indicates that the website is secured using a digital certificate issued by one of a few trusted Certification Authorities (CAs). To ensure that the digital certificate is legitimate, the browser verifies its signature using standard cryptographic algorithms. The team of researchers has discovered that one of these algorithms, known as MD5, can be misused.

The first significant weakness in the MD5 algorithm was presented in 2004 at the annual cryptology conference “Crypto” by a team of Chinese researchers. They had managed to pull off a so-called “collision attack” and were able to create two different messages with the same digital signature. While this initial construction was severely limited, a much stronger collision construction was announced by the researchers from CWI, EPFL and TU/e in May 2007. Their method showed that it was possible to have almost complete freedom in the choice of both messages. The team of researchers has now discovered that it is possible to create a rogue certification authority (CA) that is trusted by all major web browsers by using an advanced implementation of the collision construction and a cluster of more than 200 commercially available game consoles.

The team of researchers has thus managed to demonstrate that a critical part of the Internet’s infrastructure is not safe. A rogue CA, in combination with known weaknesses in the DNS (Domain Name System) protocol, can open the door for virtually undetectable phishing attacks. For example, without being aware of it, users could be redirected to malicious sites that appear exactly the same as the trusted banking or e-commerce websites they believe to be visiting. The web browser could then receive a forged certificate that will be erroneously trusted, and users’ passwords and other private data can fall in the wrong hands. Besides secure websites and email servers, the weakness also affects other commonly used software.

“The major browsers and Internet players ““ such as Mozilla and Microsoft ““ have been contacted to inform them of our discovery and some have already taken action to better protect their users,” reassures Arjen Lenstra, head of EPFL’s Laboratory for Cryptologic Algorithms. “To prevent any damage from occurring, the certificate we created had a validity of only one month ““ August 2004 ““ which expired more than four years ago. The only objective of our research was to stimulate better Internet security with adequate protocols that provide the necessary security.”

According to the researchers, their discovery shows that MD5 can no longer be considered a secure cryptographic algorithm for use in digital signatures and certificates. Currently MD5 is still used by certain certificate authorities to issue digital certificates for a large number of secure websites. “Theoretically it has been possible to create a rogue CA since the publication of our stronger collision attack in 2007,” says cryptanalyst Marc Stevens (CWI). “It’s imperative that browsers and CAs stop using MD5, and migrate to more robust alternatives such as SHA-2 and the upcoming SHA-3 standard,” insists Lenstra.

Additional information

The expert team of researchers consists of: Alexander Sotirov (independent security researcher), Marc Stevens (Cryptology Group, CWI), Jacob Appelbaum (Noisebridge, The Tor Project), Arjen Lenstra (EPFL), David Molnar (UC Berkeley), Dag Arne Osvik (EPFL) and Benne de Weger (TU/e).

More information on the discovery may be found on the websites of the researchers:

Severed-arm man hopes to return to garden

A British man says he hopes to return to his garden to plant tomatoes, four months after surgery to reattach an arm he accidentally cut off with a chainsaw.

I was trying my fork and spade one-handed over Christmas — and I’m very optimistic about putting my tomato seeds in in January, John Stirling told The Times of London.

Stirling, 59, of Peacehaven, near Brighton, cut off his left arm below the elbow in September when he slipped while trimming a tree in his yard.

I was so preoccupied with surviving that I discounted the arm, he told the newspaper. I left it on the lawn and thought, ‘That’s the last I’ll see of that.’

Gripping his wound with his right hand to staunch the bleeding, he ran along a road to get help.

He eventually found neighbor Steve Francis at home and kicked the door rather than remove his hand from his injured arm to knock.

So the first thing was I apologized for kicking his door and then said, ‘I’ve cut my arm off’. But he could see that, Stirling said.

Francis tied Stirling’s arm with a belt and a towel and recovered the arm from Stirling’s lawn, putting it in a bag of frozen sausage rolls to keep it cold, the Times said.

Twelve surgeons at Queen Victoria Hospital in East Grinstead reattached the limb in two operations lasting almost 18 hours.

Brain Affects Hearing

New Year’s Eve is marked by constant celebration and time spent with friends, but if you find yourself straining to hear, it’s your brain – not your ears – that could be to blame.

Scientists are now learning why and how age affects the brain’s dimmer switch for controlling the level of input from your ears.

Researchers say if you have trouble understanding conversation in a noisy room, you’re experiencing what’s sometimes called the cocktail party problem.

It’s just one of the first signs of an age-related hearing loss; it affects one-third of adults ages 65 to 75.

Scientists want to slow down or reverse hearing loss, and are trying to discover why our hearing goes downhill with age.

Researchers say they’re still trying to determine what else besides the dimmer switch contributes the cocktail party problem.

“I think it’s a significant player,” said Robert Frisina of the University of Rochester in New York, who is studying it.

Scientists understand that the brain can receive signals from the ears, and also talk back to them. So, when there’s too much noise, the dimmer-switch brain circuitry tells the ears to reduce their flow of signals to the brain.

Frisina said since background noise at a party tends to be lower-pitched than speech sounds, the dimmer switch probably can block out that distracting noise more than it does the speech.

In 2002, Frisina and colleagues published evidence that the dimmer switch effectiveness declines with age.

They noted the same trends occur in mice, which meant they could study those animals to get clues to what’s going on in people.

Frisina hopes to use genetically altered mice to focus his studies on particular parts of the dimmer switch circuitry. There is some evidence that shortcomings in this wiring harm the inner ear as well, he said.

While it is not yet clear how big a role the dimmer switch plays in the cocktail party problem, Frisina’s work “makes a good case that it’s got to be one of the important factors,” said Charles Liberman, who directs a research laboratory at the Massachusetts Eye and Ear Infirmary.

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Treasury invests $6 billion in GMAC

The U.S. Treasury said it purchased $5 billion in preferred GMAC stock and would lend General Motors Corp. $1 billion to invest in the company.

GM, struggling to survive a massive sales slump, owns 49 percent of GMAC and relies on the financial company to make loans to auto buyers and dealerships. Cerberus Capital Management, owning 51 percent, agreed to pump $250 million into GMAC, The Washington Post reported Tuesday.

The Treasury used money from the Troubled Asset Relief Fund. A Treasury official said the first half of the $700 billion program had not been distributed to financial firms. The deal, however, pushes the Treasury over the brink of released funds, forcing the department to ask Congress to release the second half of the $700 billion program, the Post said.

Although GM will invest in the lender, the Federal Reserve granted GMAC tentative permission to become a bank holding company on Dec. 24. That requires GM to cut its share in GMAC to 10 percent, The New York Times said.

Cerberus, similarly, must cut its company shares to 33 percent to trim its voting stake to under 15 percent.

Researchers Investigate 1918 Flu Epidemic

Researchers have discovered what caused the 1918 flu pandemic to be so fatal: a combination of three genes that allows the virus to enter the lungs and produce pneumonia.

They combined samples of the 1918 influenza with contemporary flu viruses to locate the three genes and stated that their investigation may aid in the expansion of newer flu drugs.

The findings may indicate mutations that could cause the regular flu virus to mutate into a hazardous pandemic strain.

Yoshihiro Kawaoka of the University of Wisconsin and colleagues at the Universities of Kobe and Tokyo in Japan worked with ferrets, which have the flu in a comparable way to humans.

Normally the flu produces an upper respiratory infection distressing the nose and throat, as well as fever, muscle aches and weakness.

Nevertheless, many individuals become dangerously ill and build up to pneumonia. In pandemics, like in 1918, a perilous flu strain materializes.

“The 1918 influenza pandemic was the most devastating outbreak of infectious disease in human history, accounting for about 50 million deaths worldwide,” Kawaoka’s team wrote.

It was fatal to 2.5 percent of those who fell ill, contrasting the 1 percent who dies in the yearly flu epidemic. Autopsies indicated numerous victims perished from acute pneumonia.

“We wanted to know why the 1918 flu caused severe pneumonia,” Kawaoka said.

The three genes, alongside a 1918 adaptation of the nucleoprotein, or NP gene, made contemporary seasonal flu destroy ferrets in the same way as the 1918 flu.

Flu experts concur that a pandemic of influenza will occur in the future.

Four licensed drugs can combat the flu but the viruses normally transform into defiant forms, like bacteria shifts into kinds that shirk antibiotics.

Image Caption: American Red Cross nurses tend to flu patients in temporary wards set up inside Oakland Municipal Auditorium, 1918

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Watch Our For Elderly During Winter Months

When the weather outside is frightful, it can take a heavy toll on elderly members of the community, according to an expert at Baylor College of Medicine in Houston.

“It’s essential for elders to prepare for the winter season,” said Dr. Robert Roush of the Huffington Center on Aging at BCM.

One of the main concerns is the cold winter weather, but it’s important to be sure that the precautions don’t turn into the problems.

“As we age, the body loses the ability to regulate temperature,” said Roush, also an associate professor of medicine – geriatrics at BCM. “Frail elders may turn the heat on higher than most of us, which can lead to dehydration and that causes confusion, increasing one’s risk of falling or taking too much or not enough essential medications.”

Elders must be careful to control the temperature to avoid having their places of residence become too hot or conversely too cold, leading to hypothermia. And since older people often lose their sense of thirst, always be sure to drink plenty of liquids.

Extremely cold weather can also cause severe conditions including ice and snow and power outages, so Roush recommends stocking up on essential groceries and other items ahead of time. Older people also lose lean muscle mass, and bones become more brittle; thus, there is less padding around the hips and even a small slip or fall on ice can result in a broken hip or forearm, leading to severe medical complications. 

Roush recommends having someone frequently check on elderly family members or neighbors, and help them with driving as the sun goes down earlier and it becomes difficult to see on the roads. Roush also recommends elders always have a form of communication with others, whether it’s a portable phone, cell phone or even an emergency response system. 

Another important precaution to take is getting a flu shot, but this is not just for elders.

“We recommend that elders do get the flu shot, but other family members, especially young children, should also get vaccinated to prevent spreading it to others,” said Roush.

Because the immune system is affected by age, elders should seek medical care if symptoms of a cold or flu don’t subside.

Aside from these physical and safety concerns, Roush also emphasizes preventing the holiday blues. Bereavement and other stress issues require special attention during the holidays to prevent one from becoming unduly depressed.

Roush encourages elders to get involved in holiday festivities and ask for help once in a while.  Family members and neighbors can also lend a helping hand by putting up decorations or running errands to make the holidays a joyous time for elders.

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Recession, Credit Woes Hit Hospitals

Gainesville, Florida’s first community hospital has been struggling since it was acquired by the Shands Healthcare system in northern Florida twelve years ago. But now the plug is being pulled from the 80-year-old, money-losing Shands AGH because of the recession.

Its eight-hospital not-for-profit parent company will close the 220-bed hospital next fall. Patients and staff will be moved to a nearby newer, larger teaching hospital as part of an effort to conserve $65 million over three years throughout the healthcare system.

Like many U.S. hospitals, Shands is being hit by higher borrowing costs, tight credit, investment losses and a spike in non-paying patients, many of which are recently unemployed or otherwise underinsured.

These factors have conspired to trigger more hospital closings, layoffs and other cost-cutting measures along with the abandonment or delay of many new building projects.

Experts say more closings and mergers are on the way.

“They’ll get swallowed up by somebody else, if they need to exist, and if they don’t, they’ll just close,”  Tuck Crocker, vice president of BearingPoint’s healthcare practice, told the Associated Press.

Those most at risk include rural hospitals and urban healthcare facilities in areas with excess hospital beds and many poor, uninsured patients.

Hospitals are reporting a sharp decrease in donations and investment returns, while patient visits are flat. Meanwhile, profitable diagnostic procedures and elective surgeries are on the decline as those with inadequate insurance put off healthcare.  Eventually, however, these patients turn up at emergency rooms, often seriously ill, making it difficult for hospitals to lay off staff.

These problems are magnifying many long-standing stresses, such as low reimbursements from insurance companies, even-lower payments that typically don’t cover costs for Medicare and Medicaid patients, and high technology and labor costs.

Industry consultants and hospital executives say the increasing number of people with high-deductible health plans is driving up unpaid patient bills. Many are concerned that health reform efforts by the Obama administration could mean cuts in Medicare reimbursements.  Indeed, many states short on cash have already started reducing payments for poor people covered by Medicaid.

Patients and insurers, who have been paying hospital bills more slowly during the past few months, have been complicating matters further. As a result, some think hospitals will begin requiring up-front payments for elective procedures.

Citing “prospects of a protracted recession,” bad debt and the credit crunch, Moody’s Investors Service changed its 12- to 18-month outlook from “stable” to “negative” in November for nonprofit and for-profit hospitals.

“Looking forward, the cost of borrowing will likely be higher – and may be nonexistent for lower-rated hospitals,” Moody’s said.  This is problematic because hospitals typically borrow for everything from payroll and supplies to expansions and equipment.

Paul Keckley of the Deloitte Center for Health Solutions said  he’s seen a “dramatic slowdown” in plans for new building projects since October.

“It probably means we won’t have as many new things in the hospital,” he told the AP.

Tim Goldfarb, CEO of Gainesville-based Shands Healthcare, Florida’s second-largest provider of charity care, said his system has seen bad debt jump 20 percent this year from uninsured patients.

“We write them off,” Goldfarb said.

“It’s a burden that we cannot carry any longer.”

Florida began reducing Medicaid reimbursements two years ago when its economy started to slow, Goldfarb added. He worries about another significant cut next year.

Shands already has delayed variable-rate bonds to avoid higher interest rates, deferred nearly $25 million in equipment purchases, moved management meetings to church halls and enacted employee suggestions to save millions more.

Goldfarb believes closing Shands AGH will result in nearly $100 million in cost savings over seven years, primarily by avoiding expensive renovations.  However, some administrative jobs will go away.

Although some hospitals still are doing well, closings and bankruptcies appear to be accelerating throughout the nation.

In New Jersey, for instance, where 47 percent of hospitals lost money last year, five of the 79 acute-care hospitals closed this year, and a sixth may close soon. And nearly every hospital is struggling in Hawaii, with two filing for bankruptcy and one nearly closing recently.

Throughout the country hospitals are reducing costs by outsourcing services such as security and housekeeping and cutting staff through attrition, layoffs and hiring freezes.

Most are trying not to affect those jobs that directly affect patient care, such as nurses, therapists, pharmacists and X-ray technicians.  Many of these positions already have staff shortages.

“The last thing we can do is skinny down our staffing right where we need it the most,”  Mike Killian, vice president of marketing for the three Beaumont Hospitals in suburban Detroit, told the Associated Press.

In Detroit, job losses from the auto industry and other factors now mean fewer patients with commercial insurance.  The system now predicts a $22 million loss, its first in at least four decades according to Killian.

As a result, this fall Beaumont announced a $60 million restructuring program, including a 4-10 percent pay reduction for doctors and managers, reduced overtime for some employees and the elimination of 500 jobs.

Some of the hardest-hit hospitals started cutting staff and services last spring, with more to follow, according to Rich Umbdenstock, CEO of the American Hospital Association.

Umbdenstock expects that some facilities would eliminate services that lose money, such as behavioral health treatment, or those with high operating costs such as burn units, instead of making broad-based cuts across their entire operation.

An association survey of more than 700 hospitals revealed that two-thirds have seen a decline in elective procedures and overall admissions since July, while 50 percent have seen moderate or significant increases in nonpaying patients. Meanwhile, a database on more than 550 hospitals found their third-quarter investment returns amounted to a combined loss of $832 million, a sharp reduction from last year’s $396 million gain.

Additionally, those hospitals paid 15 percent more in borrowing costs during the quarter, swinging to a 1.6 percent average loss, down from an average 6.1 percent profit margin a year ago.

“They’re having serious problems getting the capital they need for needed renovations and upgrading their facilities,” Mike Rock, an AHA lobbyist, told the AP. 

The AHA is currently seeking increased federal reimbursements from both Medicare and Medicaid.

At Exempla Healthcare, which has three hospitals in Denver and its surrounding suburbs, CEO Jeff Selberg said there’s typically a 5-7 percent annual profit margin.  However, this year’s investment losses wiped that out.  He’s now reduced a $200 million plan to upgrade facilities, information technology and clinical equipment and may stop the building of a new maternity unit and operating rooms at one of the hospitals.

Selberg said he’s seen a small increase in bad debt, but predicts more problems ahead.

“We feel like the wave is coming, but it hasn’t hit yet, and we don’t know how big this wave is going to be,” he said.

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Smoking Raises Risk Of Atrial Fibrillation

New research from the Netherlands provides yet another reason not to smoke. 

The study found that current and former smokers have an increased risk of a condition known as atrial fibrillation, or AF, the most common type of heart arrhythmia in the United States.

Those with AF experience abnormal electrical activity in the heart, which causes its two upper chambers to beat in a fast, uncoordinated rhythm. And while arrhythmia itself is not life threatening, over time AF can contribute to heart failure or stroke in some people. In the United States AF affects nearly 2 million people.

Although smoking has long been known to be a risk factor for heart disease, it was not clear whether it raised the risk of AF.  However, the latest study suggests that it does, for both current and former smokers.

Researchers in the Netherlands found that of the roughly 5,700 Dutch adults age 55 and older whose records they examined, current and former smokers were about 50 percent more likely to develop AF over 7 years.

AF “has to be added to the long list of diseases” associated with smoking, said Dr. Jan Heeringa of Erasmus Medical Center in Rotterdam, the Netherlands, in an interview with Reuters.

“An independent effect of smoking on atrial fibrillation has never been found, until now, in our study,” said Heeringa, the study’s lead researcher.

Even after the scientists accounted for factors such as age, high blood pressure and history of heart attacks, smoking remained linked to an increased AF risk.

Heeringa was surprised that former smokers had an AF risk comparable to that of current smokers.

However, the results do not suggest that kicking the habit is “meaningless,” since it is well known that smokers who quit lower their risk of developing lung cancer and heart attacks, Heeringa said.

“Stopping of smoking, at any age, has huge beneficial effects on health,” he added.

The study was published December 2008 in the American Heart Journal.

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Harvard researcher quits Shaklee

A Harvard professor and the California-based Shaklee Corp. differ on whether he approved the use of his name to promote a purportedly life-extending syrup.

David Sinclair, a anti-aging researcher at Harvard Medical School, disputes Shaklee’s contention that he approved use of his name in advertisements for the Vivix Cellular Anti-Aging Tonic, The Wall Street Journal reported Friday.

Sinclair resigned from Shaklee’s advisory board last week after the Journal questioned his seeming endorsement of Vivex, which costs $100 for a month’s supply and is made of resveratrol, a chemical found in red wine.

Shaklee Corp. calls Vivix the world’s best anti-aging supplement and asks on its Web site, How would you like to feel 25 years younger and live 25 years longer?

The question is rhetorical and is designed to engage people in a dialogue, not guarantee longer life, said Shaklee Chief Executive Roger Barnett.

In studies, resveratrol has proven beneficial in mice, not people, the Journal noted.

Lack of Sleep Can Cause Artery Calcium Deposits

U.S. researchers announced on Tuesday that an extra hour of sleep a day lowers the possibility of calcium deposits in the arteries, a forerunner to heart disease.

The discovery contributes to the list of health outcomes, like weight gain, diabetes, high blood pressure.

“We found that people who on average slept longer were at reduced risk of developing new coronary artery calcifications over five years,” said Diane Lauderdale of the University of Chicago Medical Center.

“It was surprisingly strong,” said Lauderdale. Calcium deposits in the coronary arteries are a warning of heart disease. “It’s a very early marker of future risk,” she said.

Contrasting other studies, Lauderdale’s team measured specific sleep patterns instead of taking a written survey.

They fitted a wristband on 495 people aged 35 to 47 that noted delicate body movements. Data is put into a computer program that detected specific sleep patterns.

The team took CT scans to evaluate the buildup of calcium in heart arteries, taking one scan at the beginning of the examination and one five years after.

The team noted that sleep length played an important part in the development of coronary artery calcification.

12 percent of the people in the study had artery calcification develop in the five-year study. In those who had less than five hours, 27 percent had artery calcification.

That decreased to 11 percent in those who had five to seven hours, and 6 percent in those who had seven hours a night.

Lauderdale said it unclear why this difference happened in those who slept less, but had some premises. Since blood pressure falls off while you are sleeping, it might be that those who had more sleep saw lower blood pressure in a 24-hour period.

“It’s something of a mystery,” Lauderdale said.

Kathy Parker, a sleep researcher from the University of Rochester’s School of Nursing in New York, stated that the investigation emphasizes the importance of sleep.

“People think that sleep doesn’t matter but clearly it does. Sleep deprivation is a public health problem and studies such as this show how increasing sleep duration can have tremendously positive effects,” Parker said.

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University of Chicago Medical Center

University of Rochester’s School of Nursing

In economic downturn, many turn to food

The economic downturn results in increased stress, which prompts many people to eat more than usual, a U.S. physician says.

Dr. Kendall-Reed, co-author of The No Crave Diet with husband Dr. Stephen Reed, says many people become more stressed about work stability and the economic downturn and compulsively turn to food.

I’ve been seeing nearly three new patients a day for months, and 90 percent of them have stress-related eating issues, Kendall-Reed says in a statement.

Stress stimulates the hunger center in the brain, destabilizes our blood sugar, makes us resistant to our anti-hunger messengers, and reduces our levels of ‘happy hormone’ serotonin, all of which trigger cravings that inevitably lead to weight gain.

Patients often complain at a time like this is that their diets are not working, Kendall-Reed said.

That’s simply because stress promotes storage of calories, particularly around the midsection, which is the most dangerous place to gain weight and the hardest to remove, Kendall-Reed says.

Maternal CMV Infection Raises Risk of Child’s Hearing Loss

A new study by researchers in Belgium has found that children have a higher risk of hearing loss due to congenital cytomegalovirus (CMV) infection if their mother was infected with the virus during the first trimester of pregnancy rather than in the later stages.

CMV, a type of herpesvirus, has infected nearly 50 percent of the population.  And although the virus rarely causes symptoms in those with healthy immune systems, it can cause problems when passed from a mother to her fetus during pregnancy.

Congenital CMV infection is the most common viral infection affecting the fetus, wrote Dr. Ina Foulon and colleagues from Universitair Ziekenhuis in Brussels, Belgium, in a report about their study.

The researchers had found in a previous study that children with congenital CMV carried a 22 percent risk of developing sensorineural hearing loss –the type caused by nerve damage.

In the current study, the scientists looked at the link between CMV infection occurring at different stages of pregnancy and sensorineural hearing loss in 34 children with congenital CMV infection. 

During the course of the study, 5 children were lost to follow-up and 1 died, leaving 28 remaining children.  Of these, sensorineural hearing loss occurred in 80 percent of the children born to mothers who had a CMV infection during their first trimester of pregnancy, and 8 percent of those born to mothers with a CMV infection during the second trimester.

None of the children born to mothers with CMV infections during their third trimester of pregnancy experienced sensorineural hearing loss. Progression of sensorineural hearing loss was seen in 2 children born after a maternal CMV infection during the first trimester.

The researchers explain that the vulnerability of hearing to early CMV infection in the womb may be explained by the embryological development of the ear, which occurs in large part between the 3rd and 10th week of gestation.

The study was published in the December 2008 journal Pediatrics.

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Image:University Of Utah

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journal Pediatrics

Myanmar Has Widespread Maternal Health Problems

The maternal health care issues facing women in eastern Burma (also known as Myanmar) are widespread and underreported, according to surveys by researchers at the Johns Hopkins Bloomberg School of Public Health. The researchers report that more than 88 percent of women had a home delivery during their last pregnancy and displaced women were more than 5 time as likely to receive no antenatal care. Human rights violations, like displacement and forced labor, were are also widespread and found to affect access to maternal health care. The findings are published in the December 2008 issue of PLoS Medicine.

“Health indicators are poor and human rights violations are widespread in eastern Burma,” said Luke Mullany, PhD, MHS, lead author of the study and assistant professor with the Bloomberg School’s Department of International Health. “In conflict-affected regions of Burma, research indicates that infant and child mortality rates are higher than other areas due to widespread exposure to gross human rights violations.”

According to the study, among the women surveyed, 60 percent expressed an unmet need for modern contraceptives and nearly 95 percent gave birth without the assistance of a skilled attendant or someone with labor and delivery training. Many of these women displayed signs of poor nutrition and very few received vital iron supplements or utilized insecticide-treated bed nets. In addition, more than half of the women were diagnosed as anemic and more than 7 percent tested positive for the malaria parasite.

For the study, the researchers conducted two-stage cluster sampling surveys among reproductive-aged women (15 to 45). The surveys were conducted between September 2006 and January 2007 in the Shan, Mon, Karen, and Karenni communities in eastern Burma. Mullany, along with colleagues, documented access to antenatal care, skilled attendants at birth, postnatal care, family planning services and recent exposure to human rights violations such as displacement and forced labor. With the assistance of trained survey workers who spoke the local language and were known in the community, researchers explored strategies to increase access to maternal health interventions and examined the estimated coverage of maternal health services prior to the Mobile Obstetric Maternal Health Workers (MOM) Project, a program designed to assist in providing maternal health care in eastern Burma.

“The indicators and coverage estimates provided here are strikingly worse than the already low national estimates for Burma that have been provided by various institutional reports,” said Chris Beyrer, MD, MPH, senior author of the study and professor with the Bloomberg School’s Department of Epidemiology. “Increased access to antenatal, labor delivery and newborn care services in eastern Burma is essential to improve the overall health status of these vulnerable populations. In addition, considerable political, financial and human resources are necessary to improve access to care. There needs to be emphasis on maternal and more comprehensively, reproductive health services in health programs targeting these communities.”

“Access to Essential Maternal Health Interventions and Human Rights Violations among Vulnerable Communities in Eastern Burma” was written by Luke C. Mullany, Catherine I. Lee, Lin Yone, Palae Paw, Eh Kalu Swe Oo, Cynthia Maung, Thomas J. Lee and Chris Beyrer.

The researchers were funded by grants from the Bill and Melinda Gates Institute for Population and Reproductive Health at the Johns Hopkins Bloomberg School of Public Health and the Foundation for the People of Burma.

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Reduction in Antibody Gene Rearrangement in B Cells Related to Type 1 Diabetes, Lupus

Implications for new tests and more personalized treatments for autoimmune diseases

More drafts usually mean a better product and so it also seems to go with the human immune system. As B cells develop, genes rearrange to allow their antibodies to recognize different foreign invaders or pathogens. But sometimes antibodies are created that recognize and attack the body’s own cells. These self-reactive antibodies, like early drafts of a manuscript, must be edited into safer versions. This process is called receptor editing and is important for central or early B cell tolerance, which occurs while B cells are still developing in the bone marrow. A research team led by Nina Luning Prak, M.D., Ph.D, Assistant Professor in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine, has discovered that this editing process may go awry in people with certain types of autoimmune diseases.

Prak and her colleagues, including the study’s first author, Penn MD-PhD student Anil Panigrahi, observed that the amount of antibody edits in the development of B cells is related to two types of autoimmune disease, lupus and type 1 diabetes. The findings, which appeared online this month in the Journal of Experimental Medicine, have implications for new tests and more personalized treatments for autoimmune diseases.

The investigators found a lower level of antibody editing in mouse models and in blood samples from lupus and diabetes patients. In the samples from autoimmune patients, 30 percent had low editing levels, a high proportion, but also indicative that not all autoimmunity is caused by errors in editing. A targeted, personalized approach may be necessary to treat these complex diseases, according to the researchers. New assays derived from this study to assess the level of editing may help direct appropriate therapies.

“Right now we have a very crude approach to treating autoimmunity: depleting or inactivating circulating B or T cells wholesale,” explains Prak. “Editing errors develop before B cells leave the bone marrow. However, treatments such as B-cell depletion might be less likely to work in patients with editing errors because the self-attacking B cells can be regenerated rapidly as they develop in the bone marrow.”

The researchers found a way to look at the editing history of B cells in the human and mouse samples, by monitoring the frequency of a non-functional light chain genetic rearrangement in the B cell antibody, which is termed RS. The investigators surmise that a decrease in RS levels indicates that B cells that react with self can evade editing of their self-reactivity and that defects in editing, in turn, may lead to an increased risk of developing autoimmune disease.

The measurement of RS frequency is independent of antibody specificity and, because it is non-functional and irrevertible, it can be used to monitor the level of antibody gene rearrangement in any B cell population and in any autoimmune disease. The team is now interested in testing if RS frequency is altered in other autoimmune diseases and if a low RS level in an apparently healthy person is predictive of future autoimmunity. The RS assay may also be of use to clinicians who treat patients with established autoimmunity and to researchers who are mapping genes that are associated with different underlying causes of autoimmunity.

In addition to Nina Luning Prak and Anil Panigrahi, Penn co-authors are Noah G. Goodman, Robert A. Eisenberg, Michael R. Rickels, and Ali Naji.

This work was funded by the National Institute of Diabetes and Digestive and Kidney Diseases, the Alliance for Lupus Research, the Lupus Foundation of Southern New Jersey, and the Lupus Foundation of America, Philadelphia Tri-State Chapter, Inc.

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Researchers Close In On Rotavirus

Researchers at Griffith University’s Institute for Glycomics in collaboration with colleagues at the University of Melbourne have moved a step closer to identifying a broad spectrum treatment for the dreaded ‘viral tummy bug’ or rotavirus.

These highly-infectious viruses are the leading cause of severe diarrhea in young children, responsible for thousands of hospitalizations in the developed world, and hundreds of thousands of deaths each year in developing countries.

Institute Executive Director Professor Mark von Itzstein said research findings published in the world-leading chemical biology journal Nature Chemical Biology this week demanded a total rethink of how these viruses work.

“Rotaviruses are thought to infect the bodies by sticking to certain types of sugars called sialic acids on the surface of our stomach cells. They then enter cells and reproduce rapidly, causing illness,” he said.

“Rotavirus vaccines are still in their infancy, as problems emerged with the first vaccine that was trialed a number of years ago. While other vaccines are now in clinical use, new directions are required in the development of potential drugs to prevent or treat this deadly virus.”

He said that to better understand how carbohydrates are involved in rotavirus infection, researchers had focused on treating mammalian cells with a protein called sialidase which cuts these surface sugars so the virus cannot attach.

Previous to his group’s work most scientists believed only some of the many strains of rotavirus infection could be prevented with sialidase treatment while others were apparently immune to its effects.

This led to the conclusion that some viruses depend on sialic acid to infect the body while others were thought to cause infection independent of sialic acid.

“Unsuccessful attempts to reduce rotavirus infection with this treatment led scientists to group rotaviruses into two classes: ‘sialidase-sensitive’ and ‘sialidase-insensitive’ strains,” he said.

The team used nuclear magnetic resonance spectroscopy, 3D modeling and cell-based assays to observe the interaction between the virus and host cells.

“We found that a human strain previously through insensitive to sialidase does in fact recognize and bind to sialic acid, but it is a sialic acid not accessible to sialidase treatment.” Professor von Itzstein said.

“This reveals that there is a common chink in the armor of these rotaviruses.

“This discovery is the first step in designing a broad-spectrum drug able to exploit this weakness to combat many types of human and animal rotaviruses.”

Image Courtesy Wikipedia

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College Students Comforted By Pets

A new study suggests that college students may handle stressful situations better if they have a pet.

Research has already shown that pets can improve the quality of life for people who are aging or those who are chronically ill.  But researchers at Ohio State University recently found that many college students may also benefit from owning a cat or a dog. 

A survey of students at a large university and other adults in the area found that nearly a quarter of college students surveyed believed their pets helped them get through difficult times in life.  Students who chose to live with at least one dog, one cat, or a combination of the two were less likely to report feeling lonely and depressed; something they directly attributed to their beloved pet.

These findings highlight how even younger, healthier young adults can benefit from living with our four-legged friends, said Sara Staats, lead author of the study and professor emeritus of psychology at Ohio State’s Newark Campus.

“We might not think of college students as being lonely, but a lot of freshman and sophomores are in an early transition from living at home to living in dorms or off-campus.  College is a very stressful environment for them and sometimes they can feel isolated or overwhelmed with the change,” she said.

“We found that a lot of young adults are choosing to have an animal companion for important reasons.  Many feel their pets will help get them through these difficult and stressful situations, and many more say that without their pet, they would feel lonely.”

The study was based on survey responses from nearly 350 college students at a Midwestern commuter campus and nearby community members. Only those people who currently or previously owned a cat, a dog, or a combination of the two were included in the present study.  People who were 18 to 87 years of age were all surveyed to study the differences between adults and students.

Participants were asked to indicate their current level of health, the type of pet(s) owned, and whether they believed a pet affected their overall health.  They were then asked to identify their top reasons for owning a pet in both multiple-choice and open-ended surveys.  The results were recently published in the journal Society and Animals.

The results showed that most adults and college students chose to own a pet for similar reasons.  Although the results were based on self-reports, many of those surveyed believed their pet contributed to their overall health in a number of ways. 

Nearly a quarter of all college students and adults reported that their pet was useful in keeping them active.  This answer was more common for those who owned dogs, but those who had feline friends also reported their cat helped keep them active.

Likewise, 18 percent of college students and 13 percent of adults said their pet was important to helping them cope during difficult times.  This belief was far more likely among those who were single rather than married, but it was listed by both groups in both open-ended and multiple choice questions.

But the results showed that avoiding loneliness was the top reason given by both students and adults.  Nearly identical percentages of married and single persons gave this response, but students and those over 50 years of age were far more likely to list this as their top reason.

While previous work has demonstrated that the elderly benefit from animal companionship, this study is the one of the first to suggest that animal companions help those younger than 30 years of age, Staats said.

“Most of the studies on pet ownership focus directly on those adults and older generations who have heart problems or special needs.  But there hasn’t been much recognition of that fact that young, healthy college students also derive benefits from pet ownership such as hedge against loneliness and improved ability to cope,” she said.

While the reasons for keeping a pet may be similar among adults and college students, the lifestyles differences between the two may provide clues as to why students rely on their pets more often, Staats said.

Many people in their late twenties to mid-forties have established circles of friends.  Adults usually live in areas with friends, colleagues, and family nearby, making their lives more stable than those beginning to build their lives. Many more adults are married or have started raising a family, and have years of experience learning how to cope with difficult situations.
 
Many first and second-year students, however, are in the beginning stages of building a new network of friends.  College students living far from home may find it harder to deal with difficult situations because they are thrown into a new environment and expected to find their way, often for the first time in their lives.

As a result, many students may find themselves feeling isolated and withdrawn from their environment.

“Many students said that their pets fulfill a significant role that is missing in their lives.  The pets are not a substitute for human social interaction and support, but they do provide important interaction for these kids who might otherwise feel isolated from their current environment,” Staats said.

“I wouldn’t advise everyone to go out and buy a puppy. But I think this research clearly shows that many students can benefit both psychologically and socially from living with an animal companion.”

Staats conducted the study with undergraduate psychology students Heidi Wallace and Tara Anderson.

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Migraine Medicine Can Become Addictive

Careful migraine sufferers: overusing painkillers can hurt migraine patients, causing worse headaches that can require further medication.

Taking care of migraines is important. However, it is more important to use migraine-preventing medicines to avoid the painkiller rut Rena Cerbone fell into.

“It was a double-edged sword,” Cerbone, 41, of Montclair, N.J., says. “I was taking Fiorinal on a daily basis just to function.”

Luckily for the majority of patients, migraines are not very common. Studies imply that a third of migraine sufferers are candidates for prevention medications. However, only 10 percent take them.

Having a dependence on painkillers for a few days a week can hint to overuse.

“Most people outside the specialty community are not aware of the concept,” said Dr. Stephen Silberstein of Thomas Jefferson University.

“I think there’s an epidemic in the U.S. of patients having frequent headaches, taking their pain pills over and over again,” and winding up in more pain.

Overusing any kind of medication can trigger a rebound headache after it is over.

Unfortunately for recurrent migraine sufferers, the brain becomes more receptive to pain and they get worse. If it lasts for 15 days or more a month, it’s a chronic migraine or “transformed migraine.” Dr. Richard Lipton of the Albert Einstein College of Medicine says some statistics infer there are 5 million chronic migraine sufferers.

“Chronic migraine is a condition we should be trying to prevent,” says Lipton, who also heads New York’s Montefiore Headache Center. Lipton studied if specific medicines are connected to this chronic pain.

The study followed 8,200 episodic migraine sufferers for one year. They noted that 2.5 percent developed a state of chronic migraine. Those who took drugs like Percocet, or Fiorinal, were most likely to become worse, said Lipton and his colleagues.

Several patients will require narcotics or barbiturates to treat their migraines, especially for chronic ones, Lipton admits. However, “the reality is they’re overused” in migraines, he states, warning that patients who need these medications should limit themselves to weekly doses.

Getting yourself off migraine medication is still very difficult. Cerbone employed numerous attempts to quit before she located a migraine specialist who eliminated her prescription painkiller completely and put her on a daily prevention medication. It’s working very well, she says.

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Shape-Changing Molecules Drive Frangrance

Shakespeare wrote “a rose by any other name would smell as sweet.” But would it if the molecules that generate its fragrance were to change their shape?

That’s what Dr. Kevin Ryan, Assistant Professor of Chemistry at The City College of New York (CCNY) and collaborators in the laboratory of Dr. Stuart Firestein, Professor of Biology at Columbia University, set out to investigate. Their findings, reported today in the journal “Chemistry & Biology,” shed new insight into how our sense of smell works and have potential applications in the design of flavors and fragrances.

When odor-producing molecules, known as odorants, pass through the nose, they trigger intracellular changes in a subset of the approximately 400 different varieties olfactory sensory neurons (OSN) housed in the nose’s internal membrane tissue, Professor Ryan explained. The unique reaction pattern produced, known as the olfactory code, is sent as a signal to the brain, which leads to perception of odors.

Professor Ryan and his team wanted to learn how these receptor cells respond when odorants change their shape. They studied the odorant octanal, an eight-carbon aldehyde that occurs in many flowers and citrus fruits. Octanal is a structurally flexible molecule that can adapt to many different shapes by rotating its chemical bonds.

The researchers designed and synthesized eight-carbon aldehydes that resembled octanal, but had their carbon chains locked by adding one additional bond. These molecules were tested on genetically engineered OSNs known to respond to octanal. This work was done in Professor Firestein’s laboratory at Columbia.

The aldehyde molecules that could stretch to their greatest length triggered strong activity in the OSNs. However, those molecules whose carbon chains were constrained into a U shape blocked the receptor and left the cell unable to sense octanal.

“Conformationally constrained odorants were more selective in the number of OSNs they activated,” Professor Ryan noted. “The results indicate that these odorant molecules might be able to alter fragrance mixture odors in two ways: by muting the activity of flexible odorants present in a mixture and by activating a smaller subset of OSNs than chemically related flexible odorants. This would produce a different olfactory code signature.”

Olfactory receptors belong to the G-protein coupled receptor (GPCR) class of proteins, a family of molecules found in cell membranes throughout the body. Professor Ryan pointed out that half of all commercial pharmaceuticals work by interaction with proteins within this family. Thus, the findings could also have applications to GPCR drug design, as well.

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Navigating Through Maze Is Possible For Blind Man

It has been discovered that a blind person could navigate through a maze of obstacles unaided using the power of sense alone.

A man left blind by a stroke was able to intuitively walk around chairs and boxes without bumping into them using hidden pathways in the brain.

According to the study, we all use subconscious brain resources and can do things we think we are unable to do.

Research was published in Current Biology by the Harvard Medical School.

The patient was left blind after damage to the visual (striate) cortex in both hemispheres of the brain following consecutive strokes.

The patient, known as TN, has normal eyes but his brain cannot process the information they send in, rendering him totally blind.

He was previously known to have “blindsight” which is the ability to detect things in the environment without being aware of seeing them.

For example, he responds to the facial expressions of others.

However, he walks like a blind person, using a stick to track obstacles and requires guidance by other when walking around buildings.

The scientist set up video recording around him that showed him completing the obstacle course set up, without the aid of his cane or another person.

Dr. Beatrice de Gelder of Tilber University, said that TN was “not aware of doing anything exceptional” and thought all he had done was walk straight ahead along a long corridor.

She said that it was an important message for those with brain damage in particular.

“You can experience a total loss of your cortical vision but still retain some capacity to move around inside and out without damage to yourself,” she told the BBC.

“It shows us the importance of these evolutionary ancient visual paths. They contribute more than we think they do for us to function in the real world.”

Sonai Rughani, an optometrist and senior advisor to the RNIB, a U.K. charity, said it was a striking observation, and further evidence that the brain is very flexible.

She also added that a relatively few number of people were left behind through brain injury, and most people with sight problems following a stroke could be helped by complex therapy regimes.

“These are very exciting findings but it will require further research,” she added.

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