Loneliness Can Pose Major Health Risks For Seniors

William Harms, University of Chicago

Feeling extreme loneliness can increase an older person’s chances of premature death by 14 percent, according to research by John Cacioppo, professor of psychology at the University of Chicago.

Cacioppo and his colleagues’ work shows that the impact of loneliness on premature death is nearly as strong as the impact of disadvantaged socioeconomic status, which they found increases the chances of dying early by 19 percent. A 2010 meta-analysis showed that loneliness has twice the impact on early death as does obesity, he said.

Cacioppo, the Tiffany & Margaret Blake Distinguished Service Professor in Psychology at the University, joined other scholars at a seminar on “The Science of Resilient Aging” Feb. 16 at the American Association for the Advancement of Science annual meeting in Chicago.

The researchers looked at dramatic differences in the rate of decline in physical and mental health as people age. Cacioppo and colleagues have examined the role of satisfying relationships on older people to develop their resilience, the ability to bounce back after adversity and grow from stresses in life.

The consequences to health are dramatic, as feeling isolated from others can disrupt sleep, elevate blood pressure, increase morning rises in the stress hormone cortisol, alter gene expression in immune cells, and increase depression and lower overall subjective well-being, Cacioppo pointed out in a talk, “Rewarding Social Connections Promote Successful Aging.”

Cacioppo, one of the nation’s leading experts on loneliness, said older people can avoid the consequences of loneliness by staying in touch with former co-workers, taking part in family traditions, and sharing good times with family and friends – all of which gives older adults a chance to connect others about whom they care and who care about them.

“Retiring to Florida to live in a warmer climate among strangers isn’t necessarily a good idea if it means you are disconnected from the people who mean the most to you,” Cacioppo told University of Chicago’s William Harms. Population changes make understanding the role of loneliness and health all the more important, he explained.

“We are experiencing a silver tsunami demographically. The baby boomers are reaching retirement age. Each day between 2011 and 2030, an average of 10,000 people will turn 65,” he said. “People have to think about how to protect themselves from depression, low subjective well-being and early mortality.”

Although some people are happy to be alone, most people thrive from social situations in which they provide mutual support and develop strong rapport. Evolution encouraged people to work together to survive and accordingly most people enjoy companionship over being alone.

Research by Cacioppo and his colleagues has identified three core dimensions to healthy relationships — intimate connectedness, which comes from having someone in your life you feel affirms who you are; relational connectedness, which comes from having face-to-face contacts that are mutually rewarding; and collective connectedness, which comes from feeling that you’re part of a group or collective beyond individual existence.

It is not solitude or physical isolation itself, but rather the subjective sense of isolation that Cacioppo’s work shows to be so profoundly disruptive. Older people living alone are not necessary lonely if they remain socially engaged and enjoy the company of those around them. Some aspects of aging, such as blindness and loss of hearing, however, place people at a special risk for becoming isolated and lonely, he said.

Research To Unlock The Brain’s Mysteries Detailed At AAAS Conference

redOrbit Staff & Wire Reports – Your Universe Online

Experts from the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland are combining experimental data with the core principles of brain organization in order to create a detailed computer model which will allow them to conduct supercomputer-based simulations of the brain’s inner workings.

“Brain simulation allows measurements and manipulations impossible in the lab, opening the road to a new kind of in silico experimentation,” said the EPFL’s Henry Markram. The amount of neuroscience data is resulting in a tremendous deluge of brain-related information, with more constantly on the way – making it a challenge to search, access and analyze all this data.

The project is one of several being pursued by scientists affiliated with the Human Brain Project, a 10-year, $1.3 billion project designed to construct a new information and communications technology infrastructure for neuroscience and brain-related research in medicine.

The project was launched in October 2013 and involved over 80 top universities and research institutions from Japan, China, the US and 22 European nations. The group plans to announce over a dozen new research partnerships prior to the end of the month, and gave an update on their ongoing projects Sunday during “Inventing New Ways to Understand the Human Brain” at the 2014 AAAS Annual Meeting in Chicago.

“Understanding the human brain is one of the greatest challenges facing 21st century science,” officials from the EPFL said in a statement Sunday. “If we can rise to this challenge, we will gain profound insights into what makes us human, develop new treatments for brain diseases, and build revolutionary new computing technologies that will have far reaching effects, not only in neuroscience.”

In the panel discussion, EPFL’s Sean Hill, leader of the Human Brain Project’s Neuroinformatics Platform, explained that the newly-developed platform will provide scientists with the tools they need to manage, navigate and annotate spatially-referenced atlases of the human brain. These tools will be a fundamental part of the project’s brain-modeling effort, he added.

The Human Brain Project’s Neuroinformatics Platform will combine several different types of information, the researchers explained. For example, Seth Grant of the University of Edinburgh Centre for Neuroregeneration explained that he and his colleagues were developing new techniques to decode the underlying molecular principles of the brain’s organization.

One aspect of that is how individual proteins assemble into larger complexes, and as Grant explained during the AAAS meeting, this research could be applied to treat the genetic mutations behind disorders such as autism and schizophrenia. Likewise, understanding more about how the brain computers can assist the development of new technology, combining realistic brain models with hardware for an entirely new paradigm of computing.

Furthermore, Dr. Christof Koch explained at the conference that he and colleagues from the Allen Institute for Brain Science were working on a 10-year plan to understand the brain’s structure and function by mapping mice and human cell types with computer simulations.

Their goal is to figure out the cell’s network, as well as how they encode, relay and process information. “The project… promises massive, multimodal, and open-access datasets and methodology that will be reproducible and scalable,” the researchers explained.

Harvard University scientists are also participating in the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, which is designed to map all of the brain’s neurons using advancing technology. At the meeting, genetics professor George Church gave a progress report on new tools for measuring brain cell development and connectivity in both rodent and human samples.

Natural Management of Fibromyalgia

Natural Management of Fibromyalgia

A look at what fibromyalgia really is

Fibromyalgia is a disease that affects the central nervous system of a patient and results in chronic in widespread pain that cannot be pinpointed to one particular physiological cause.  Patients affected by this disease tend to have pain centers that are hyperactive when compared to healthy people.

Even the slightest tactile pressure can cause intense pain.  This is because the central nervous system of a patient suffering from fibromyalgia overreacts to and amplifies the sensations of pain and tactile pressure that come in from various parts of the body.

The chronic pain that is associated with this disease can cause people to lapse into depression and further cause different psychological problems.  Other problems that are associated with this disease include gastric problems, sleep deprivation and the irregular sleep, irregular moods and other psychological and physiological issues.

One of the major causes of fibromyalgia is thought to be an irregular action of dopamine receptors and serotonin receptors in the central nervous system.  Another thing that can contribute to fibromyalgia is stress.

Current hypotheses about cause & treatment

Even with the best minds in medical science and medical research working on the problem of fibromyalgia no single cause has diffidently been identified.  There are a number of problems and similarities that are observed in all fibromyalgia patients.  There currently three identified areas that may contain potential causes for fibromyalgia.  The first of these is genetics.  People have parents are close relatives who have suffer from fibromyalgia in the past are at a higher risk for developing this disease.

This is because some of the problems that are thought to contribute to the development of fibromyalgia are hereditary and thus genetically linked.  Another potential cause of fibromyalgia is thought to be infections by certain diseases.  This is because it has been seen that some diseases and infections by certain pathogens act as triggers that start fibromyalgia.

Another major cause of fibromyalgia is thought to be physical and mental trauma.  Psychological from a such as posttraumatic stress disorder or physical trauma such as injuries to the neck or the head place people at a higher risk of contracting fibromyalgia.

Simple & effective natural remedies

As fibromyalgia is currently best understood as a physiological problem, most of the treatments prescribe for this disease consists of medications and chemical drugs that tend to suppress the psychological and physiological aspects of fibromyalgia.  There are however, certain simple and actual measures that can be taken to mitigate the effects of fibromyalgia.

It should be remembered that this is a disease whose problems are triggered by stress and psychological distress.  One of the best natural remedies for people suffering from fibromyalgia is to take a diet that is rich in natural painkillers and analgesics.

There are several natural herbs and foods network to calm the central nervous system and hence help with the chronic pain that is associated with fibromyalgia.  Another great problem that is faced by patients suffering from fibromyalgia is a lack of proper sleep.

This is caused you to interruptions in their sleep patterns that role of the entire sleep cycle.  This causes continuous fatigue and tiredness even after long periods of sleep.  This in turn increases the general widespread pains their cause by fibromyalgia and also wreaks havoc on the regulation of moods, cognitive ability, ability to concentrate and the ability to perform well in social situations.  These problems can be greatly mitigated and reduced by taking natural supplements and diet that promotes sound sleep and reduces problems like sleep apnea.

One of the best things that of fibromyalgia patient can do is to get a good night’s sleep.  There are several national remedies that help accomplish this.  One of these is to drink a warm glass of milk with a teaspoon of honey in order to promote deep sleep.  Another remedy is to sleep on the side rather than facing upward as this greatly reduces the problems associated with snoring and sleep apnea.

The best way to combat the problems associated with fibromyalgia is to make certain import and lifestyle changes and live a healthier life.  This includes balancing the diet and regularly exercising.

Exercise is very helpful in reducing stress and regulating good moods.  It also help to strengthen the muscles and skeletal structure of the body and combat pain.

Smoking and alcohol consumption should either be eliminated or reduced as much as possible to minimize the physiological stress that the body undergoes on consumption of the substances.

Two other things a patient can do is to limit caffeine intake and that pays the activity levels throughout the day to reduce any unnatural stresses that maybe physiological or psychological.

Implanted Occipital Nerve Stimulator Proves Beneficial for Fibromyalgia

Implanted Occipital Nerve Stimulator Proves Beneficial for Fibromyalgia

People with fibromyalgia deal with a great amount of chronic pain resulting from muscle tenderness and stiffness.  This can be debilitating, as pain can range from moderate to severe.  It is important that people with fibromyalgia learn to manage their pain in whatever way works best for them.  Each individual will have different ways to ease and deal with pain, and it is important to set a routine based on what works best for individuals.

There is no cure for fibromyalgia, so pain management is the most important focus of treatment.  Pain management can involve exercise practices, medications, stress-relief techniques, and other practices.  Another type of pain management is done through an implanted occipital nerve stimulator.  This has recently been proven as beneficial for those with fibromyalgia pain.

Occipital nerve stimulation (ONS) has improved pain and quality of life for people with fibromyalgia.  This treatment is associated with changed in activation patterns of the areas of the brain that produce pain response.

One experiment conducted in Belgium involved 25 patients with fibromyalgia.  Each patient had a lead implanted underneath the occipital protuberans, and ONS was conducted for six months.  After six months of treatment, significant improvements in pain were noted.  This was based on a questionnaire designed specifically for this study to examine levels of pain, awareness, quality of life etc. This study did conclude that pain was reduced as a result of ONS.

In a follow up study, positron emission tomography scans were done on six patients who had fibromyalgia and implanted occipital nerve stimulators, both with the stimulation and without it.  The researchers found significant differences in the patters of those who had and did not have ONS activators.  During the stimulation, the radioactive traver profile was altered significantly in multiple regions of the brain.  These altered regions include the cingulated cortex, posterior cingulated cortex, dorsolateral prefrontal cortex, and others.

In this study, other factors were controlled as best as possible.  Before being treated, patients were tested for their baseline mood, pain, fatigue, and other information.  This was a double-blind experiment, meaning that neither the participants nor the researcher knew which participants were assigned to each group.  This type of study eliminates any behavior by the participants or researcher that may affect the outcome of the study.

The results indicated that there was a significant decrease in pain intensity, and pain catastrophizing during the stimulations.  Nine of eleven participants responded to trial treatment, although two may have been due to placebo effect.  Permanent implantation was done on nine patients following the initial trial.  Pain for these patients continued to remain decreased even after six months.  Other improvements include less fatigue, less trigger points, and other improvements.

Through these experiments, researchers concluded that ONS is a beneficial treatment for fibromyalgia.  The positive effects become stable after six months of implementation, and continue after.

People with fibromyalgia are always looking for different ways to control their pain.  ONS in an invasive measure that can make a positive impact on those who are suffering greatly from pain.

Others prefer non-invasive methods, including massage, exercise, and other.  People with fibromyalgia regularly receive massage, either from a professional or at home.  Those who choose to see a professional should inform the masseuse of the condition and be sure that the bodywork done is gentle and not painful.  Massage done at home can also be helpful in reducing pain, as it can be done daily and at a person’s convenience.  At home massage can be done with a tennis ball, gently rolling over tight and sore muscles with gentle pressure.

Another treatment involves movement and exercise.  Exercise can increase serotonin levels in the brain and can lead to positive affect.  There are a few types of exercise that are recommended for people suffering from fibromyalgia pain.  Yoga is a great way to gain flexibility and strength.  Restorative or gentle yoga is good for people who have fibromyalgia, as this type of yoga moves slowly and is gentle.  Tai Chi has also been recommended, as it involves steady slow movements and conscious breathing.  Practicing yoga or tai chi can reduce stress levels and can be meditative for people, allowing them to take a break and relax their mind and body.

Warm showers or baths can also be helpful, especially in the morning as many people wake up with great stiffness in their muscles and joints.  Taking a warm shower or bath will relax muscles and alleviate some stiffness.

There are many different treatments for fibromyalgia pain management, and individuals should consult with a doctor to find the treatment program best for them.

Mystery Of Missing Genetic Disease Risk May Have Been Solved

redOrbit Staff & Wire Reports – Your Universe Online

If a combination of genetic variants are at least partially responsible for a person’s susceptibility to common diseases, then why has research to look for those genetic causes only successfully explained a fraction of the heritable risk of developing them? That’s the question that the authors of a new PLOS Genetics study set out to answer.

The study, which was led by scientists at the Institute of Cancer Research (ICR), London, demonstrates for the first time in cancer that some common genetic variants could actually indicate the presence of far more influential rare mutations that have not yet been discovered. Experts from over two dozen leading academic institutions participated in the research, which could help explain what the authors refer to as the mystery of the missing genetic risk.

“One important unanswered question in cancer genetics – and in genetics of common disease more generally – is why the genetic mutations we’ve discovered so far each seem to have such a small effect, when studies of families have shown that our genetic make-up has a very large influence on our risk of cancer,” said study co-leader and ICR oncogenetics professor Ros Eeles.

“Our study is an important step forward in our understanding of where we might find this ‘missing’ genetic risk in cancer,” Eeles, who is also an Honorary Clinical Consultant at The Royal Marsden NHS Foundation Trust, added in a statement. “At least in part, it might lie in rarer mutations which current research tools have struggled to find, because individually each does not affect a large number of people.”

Eeles and her colleagues recruited 20,440 men suffering from prostate cancer, as well as 21,469 without the disease, and identified a cluster of four common genetic variants on chromosome 17 which appeared to give rise to a slight increase in the risk of developing the condition (using standard statistical techniques). However, the study also revealed an alternative explanation for that risk signal in some of the study participants.

As it turns out, a small proportion of the men with the common chromosome 17 variants were also carriers of a rare mutation in a nearby gene (HOXB13) known to be associated with prostate cancer. With this so-called synthetic association, the number of men carrying a cancer risk variant was far lower than experts had initially believed, but those who did inherit a variant faced a higher-than-expected prostate cancer risk.

“The discovery shows that the prevailing genetic theory – that common cancers are predominantly caused by the combined action of many common genetic variants, each with only a very small effect – could potentially underestimate the impact of rare, as yet undiscovered mutations,” the Institute said. “The results are important because they show that there is a need for renewed effort by geneticists to find the causal variants, whether common or rare, behind the many common cancer-associated variants identified in recent years.”

“As far as we are aware, this is the first known example of a ‘synthetic association’ in cancer genetics,” study co-leader and ICR senior staff scientist Dr. Zsofia Kote-Jarai added. “It was exciting to find evidence for this theory, which predicts that common genetic variants that appear to increase risk of disease by only a modest amount may indeed sometimes be detected purely due to their correlation with a rarer variant which confers a greater risk.”

Dr. Kote-Jarai went on to note that their research does not imply how widespread the phenomenon might be, but that it demonstrated how important it was to pinpoint the causal genetic changes behind the common variants already proven to influence disease susceptibility. The doctor also reported that large-scale sequencing studies might be needed to identify possible causal variants when fine-mapping genetic associations with disease.

In Regards To Science Fiction, Truth Is Often Stranger

April Flowers for redOrbit.com – Your Universe Online

Science fiction borrows from, and sometimes anticipates, the state of the art in scientific progress. This can be seen from warp drives to hyperspace, and has resulted in the perception that science and science fiction have a causal relationship. People assume that science finds direction from and fulfills the science fantasy laid out before it.

According to Lawrence Krauss, a Foundation professor in the School of Space and Earth Exploration and the Department of Physics at Arizona State University, this is rarely the case. Krauss admits that science fiction has taken inspiration from the cutting edge science of its day. It is also true, as Stephen Hawking wrote in the preface to Krauss’s bestselling book, ‘The Physics of Star Trek,’ science fiction helps inspire our imaginations. Despite this, Krauss believes that science fiction is not a match for reality.

“Truth is stranger than fiction,” Krauss, a renowned theoretical physicist and science popularizer, said at the 2014 annual meeting of the American Association for the Advancement of Science (AAAS) in Chicago. His talk, “Physics of the future,” was part of a session entitled “Where’s my flying car? Science, science fiction and a changing vision of the future.”

“The imagination of nature far exceeds the human imagination, which is why we constantly need to probe the universe via experimentation to make progress,” he said. “In fact, I tend to think that what makes science fiction most interesting is what they missed, not what they got right.”

Krauss cited such examples as the World Wide Web, developed at the CERN scientific laboratory, and which governs the world in ways we could never have anticipated. Another example given was H. G. Wells’ “The World Set Free,” which is often quoted as a prophetic book. The novel was published in 1914 and anticipated the development of atomic weapons that would be used in war. Decades before they became a harsh reality in the modern world — and perhaps influencing some of the scientists who created the real weapons — the novel coined the term “atomic bombs.”

“Nevertheless not only did Wells’ continually burning atomic weapons bear no resemblance to the engines of destruction in the real world,” Krauss emphasized, “he thought it would unite the world into one society whereas we are painfully aware that it hasn’t changed human thinking, except to divide the world into nuclear haves and have-nots.”

“Nevertheless it is instructive, and fun, to compare the ‘science’ of science fiction with that of the real world,” said Krauss, who also is the director of the Origins Project at ASU. “Rather than dwelling on things that don’t work, it is fun to explore closely related things in the real world that might work.”

A variety of classical science fiction standbys were the focus of Krauss’s talk — including space exploration, faster than light travel, time travel and teleportation. In science fiction, space travelers move freely about the universe, fulfilling their manifest destiny in space, while in reality, we remain stuck on Earth. According to Krauss, the reality of the situation is vastly different. The cost of space travel is exorbitantly high, in both money and energy. It is a very risky endeavor and humans, as “hundred-pound bags of water,” are not built for space.

Krauss did have positive news for science fiction lovers. He described how exotica live warp drive and time travel are not ruled out by our current knowledge of the laws of nature. From a practical perspective, however, even if they are possible in principle, they are likely to be impossible in practice. While he doubts that people will ever be “beamed” from one place to another, quantum teleportation may revolutionize computing in ways that science fiction has just begun to come to grips with.

Krauss has authored more than 300 scientific publications and nine books, including the international bestseller ‘The Physics of Star Trek,’ a tour of the Star Trek universe and our universe, and ‘Beyond Star Trek,’ which addressed recent exciting discoveries in physics and astronomy and takes a look at how the laws of physics relate to notions from popular culture.

Krauss concluded his talk with the prediction that the future of science fiction is fraught with problems.

“The best part of physics of the future is that we have no idea what the exciting discoveries of the future will be,” he said. “If I knew what the next big thing would be, I would be working on it now!”

Image 2 (below): Lawrence Krauss, Foundation professor at Arizona State University, says science fact is stranger than science fiction. Credit: Tom Story, Arizona State University

Sleep Apnea May Contribute To Fatigue In Multiple Sclerosis

April Flowers for redOrbit.com – Your Universe Online

The fatigue that many people with multiple sclerosis (MS) feel is often written off as just being part of the territory of their chronic neurological condition.

A new study from the University of Michigan, published in the Journal of Clinical Sleep Medicine, suggests that a large number of MS patients might have an undiagnosed — and treatable — sleep disorder, known to cause fatigue: obstructive sleep apnea, or OSA.

The research team, from the U-M Health System’s Sleep Disorders Center, conducted a study involving 195 patients at the U-M Multiple Sclerosis Center. Based on a method of screening for the condition known as the STOP-Bang questionnaire, they found that 56 percent were at an increased risk for OSA. Most of those had never had a formal diagnosis, however, and less than half who had been told they had sleep apnea were using standard treatment for it.

The results also showed that patients who were more fatigued were more likely to have an increased risk for sleep apnea. This was true even factoring in other aspects that might have contributed to feelings of fatigue, such as age, gender, body mass index (BMI), sleep duration, depression, and other nighttime symptoms.

The results are based on data gathered from one questionnaire designed by the authors, and four validated instruments designed to assess daytime sleepiness, fatigue severity, insomnia severity and obstructive sleep apnea risk. The researchers also accessed the patients’ medical records to examine clinical characteristics that may predict fatigue or obstructive sleep apnea risk.

“We were particularly surprised by the difference between the proportion of patients who carried an established diagnosis of obstructive sleep apnea – 21 percent – and the proportion at risk for obstructive sleep apnea based on their STOP-Bang scores, which was 56 percent,” says Tiffany Braley, MD, MS.

“These findings suggest that OSA may be a highly prevalent and yet under-recognized contributor to fatigue in persons with MS. Our study suggests that clinicians should have a low threshold to evaluate MS patients for underlying sleep disturbances.”

The research team consisted of Braley, who is an assistant professor of Neurology and multiple sclerosis specialist at the U-M Medical School; Ronald Chervin, MD, MS, director of the U-M Sleep Disorders Center; and Benjamin Segal, MD, director of the U-M MS Center.

MS is an immune-mediated disease of the central nervous system. It causes inflammation and damage of the brain and spinal cord, as well as a number of chronic symptoms. For MS patients, fatigue is one of the most disabling of the chronic symptoms.

“Obstructive sleep apnea is a chronic illness that can have a destructive impact on your health and quality of life,” said American Academy of Sleep Medicine President Dr. M. Safwan Badr. “People with multiple sclerosis who are found to have a high risk of OSA should be referred to a board certified sleep medicine physician for a comprehensive sleep evaluation.”

Braley cautions that the researchers can’t prove that the patients felt more fatigued because they had a high score on a sleep apnea risk survey simply based on survey results. However, she notes, “the findings should prompt doctors who treat MS patients to consider sleep apnea as a possible contributor to their patients’ fatigue, and recommend appropriate testing and treatment.”

Traditionally, sleep apnea is treated with a CPAP, or continuous positive airway pressure, machine. The CPAP machine has a mask device that applies a stream of air to the upper airway to keep it open during sleep.

The study participants had an average age of 47 and, on average, had lived with MS for 10 years. Consistent with the prevalence of MS in the United States, two-thirds of the participants were female and two-thirds were taking a medication to treat their MS, while three-quarters had the relapsing-remitting form of the disease.

MS is the most common disabling neurological disease among young adults, with approximately 400,000 people in the US affected, according to the National Multiple Sclerosis Society. OSA affects up to seven percent of men and five percent of women, according to the American Academy of Sleep Medicine.

Parents Who Keep Work And Family Tasks Separate Find Life More Meaningful

redOrbit Staff & Wire Reports – Your Universe Online

Conflict between earning a living and caring for their children can make working parents feel as though what they are doing at any given time is less meaningful, according to research presented Friday at the Society for Personality and Social Psychology (SPSP) conference in Austin, Texas.

According to Kostadin Kushlev, of the University of British Columbia (UBC), and his colleagues, simply thinking about money diminishes the meaning that mothers and fathers derive from parenting. Their findings are among an increasing number of scientific research identifying how, when and why parenthood results in either joy or misery.

“The relationship between parenthood and well-being is not one and the same for all parents,” Kushlev said. While that would appear to be a fairly obvious statement, social scientists had not previously determined which psychological and demographic factors affect a parent’s level of happiness.

The study authors were inspired by previous research associating parenthood with a reduced level of well-being.

In their research, the doctoral student and his adviser, Dr. Elizabeth Dunn of the UBC Department of Psychology, set out to determine which aspects of life could influence the amount of pleasure and/or pain that men and women derived from being parents. They focused specifically on the issue of wealth.

One study, appearing in a recent edition of Journal of Experimental Social Psychology, Kushlev and Dr. Dunn discovered that parents with a higher socioeconomic status experienced a reduced sense of meaning while caring for their youngsters, but not when it came to other day-to-day activities.

Furthermore, a field study conducted as part of that same paper revealed that showing people images of currency while having them complete a questionnaire at a festival with their children also lowered their levels of meaning in life. In later research, the duo expanded on that study by showing participants money while testing the influence of parental objectives while they were also caring for kids at this type of event.

In the latter study, Kushlev’s team had one group of parents read a paragraph about the festival in terms of achievement and productivity and a second group read a different paragraph that discussed the event solely in terms of satisfying their children’s needs. Both groups were then polled about parenting and their sense of meaning.

“This design allowed us to see whether money compromises meaning because of the conflict between the goals associated with money and the goals and the behaviors that parenting normally demands,” Kushlev explained.

They discovered that activating goals related to both money-making and child-satisfying created an internal conflict within parents in which those men and women felt less meaning in what they were doing. While the effect was also experienced by fathers, the researchers said that it was more pronounced in women.

“Money seems to compromise meaning for mothers but not for fathers when they are spending time with their children,” Kushlev explained. “This finding is consistent with other, unpublished research that suggests that money tends to activate achievement and self-promotion motivations more strongly in women than men.”

While he and Dr. Dunn work to better understand this gender discrepancy, he advises parents to make sure that they keep their work life and their family life as distinct from one another as possible, “so that work- or money-related goals are not active when parents are spending time with their children. The less we mix our various goals and motivations, the more meaning in life we may be able to experience from our various daily activities.”

The Lifespan Of The Worm Predicted With Accuracy In New Study

Lee Rannals for redOrbit.com – Your Universe Online
Scientists claim they have found a way to accurately predict the lifespan of a worm, meaning fortune tellers should be updating their LinkedIn profiles pretty soon.
Researchers, publishing a paper in the journal Nature, say they have found a way to determine an organism’s lifespan by looking at the bursts of activity in the mitochondria, which is part of the cell which generates energy.
“Mitochondrial flashes have an amazing power to predict the remaining lifespan in animals,” study lead Meng-Qiu Dong, a geneticist who studies ageing in the Caenorhabditis elegans worm at the National Institute of Biological Sciences in Beijing, said in a statement. “There is truth in the mitochondrial theory of aging.”
The worms in the study usually live for about 21 days and are at their peak of reproductive fitness at just three days old. The team found that worms with low mitoflash activity lived longer, while those with high mitoflash activity died before 21 days.
“Mitoflash activity in Caenorhabditis elegans pharyngeal muscles peaked on adult day 3 during active reproduction and on day 9 when animals started to die off,” the authors wrote in the journal. “A plethora of genetic mutations and environmental factors inversely modified the lifespan and the day-3 mitoflash frequency. Even within an isogenic population, the day-3 mitoflash frequency was negatively correlated with the lifespan of individual animals. Furthermore, enhanced activity of the glyoxylate cycle contributed to the decreased day-3 mitoflash frequency and the longevity of daf-2 mutant animals.”
According to the study, worms carrying a genetic mutation known to extend life to 39 days exhibited fewer mitoflash bursts than genetically healthy worms. The same pattern was seen when the researchers exposed the worms to short periods of starvation and heat shock.
The researchers said the most shocking finding came when Dong treated a long-lived worm to increase its production to reactive oxygen molecules. This technique shortened the worm’s life and increased the rate of mitoflashes.
“These results demonstrate that the day-3 mitoflash frequency is a powerful predictor of C. elegans lifespan across genetic, environmental and stochastic factors,” the team wrote in the journal. “They also support the notion that the rate of aging, although adjustable in later life, has been set to a considerable degree before reproduction ceases.”

Deep Brain Region Controls How Quickly We Make Decisions About Love

Lee Rannals for redOrbit.com – Your Universe Online

According to a study published in the journal Current Trends in Neurology, a region found deep within the brain is able to control how quickly people make decisions about love.

The research is the first to provide causal clinical evidence that an area of the brain known as the anterior insula plays an instrumental role in love.

“The current work makes it possible to disentangle love from other biological drives,” the authors wrote. “Such studies could also help researchers examine feelings of love by studying neurological activity rather than subjective questionnaires.”

The 48-year-old patient made decisions normally about lust but showed slower reaction times when making decision about love when compared to a typical patient matched on age, sex and ethnicity.

“This distinction has been interpreted to mean that desire is a relatively concrete representation of sensory experiences, while love is a more abstract representation of those experiences,” Stephanie Cacioppo, lead author of the study and a neuroscientist at the University of Chicago, said in a statement.

During the study, the patient and the control group of seven other males were shown 40 photographs at random of attractive, young women dressed in appealing dresses. They were asked whether these women were objects of sexual desire or love. The patient with a damaged anterior insula from the stroke showed a much slower response when asked if the women in the photos could be objects of love.

“We reasoned that if the anterior insula was the origin of the love response, we would find evidence for that in brain scans of someone whose anterior insula was damaged,” Cacioppo said in a statement.

The findings suggest that the posterior insula is implicated in feelings of lust or disease, while the anterior insula has a role in the more abstract representations involved in love.

Study Highlights Indigenous Response To Natural Disaster

Experience in American Samoa could be replicated elsewhere
When a tsunami struck American Samoa in 2009, indigenous institutions on the islands provided effective disaster relief that could help federal emergency managers in similar communities nationwide, according to a study from the University of Colorado Denver and the University of Hawaii at Manoa.
The study found that following the tsunami, residents of the remote U.S. territory in the South Pacific relied on Fa’aSamoa or The Samoan Way, an umbrella term incorporating a variety of traditional institutions governing the lives of its citizens.
“We found that communities like this have strong traditions that may not fit into the Federal Emergency Management Agency (FEMA) model but they are still highly effective,” said study author Andrew Rumbach, PhD, assistant professor of planning and design at CU Denver’s College of Architecture and Planning. “We think these same kinds of traditions could play important roles in disaster preparation, response and recover in American Indian communities, Alaskan villages, and among other indigenous people.”
The study was published Thursday in the journal Ecology and Society.
The 2009 tsunami resulted from three undersea earthquakes that sent a wall of water crashing into American Samoa, killing 34, injuring hundreds more and causing tens of millions of dollars in damage.
Immediately after, the leaders or matai began organizing the young men or aumaga to begin rescuing tsunami victims and clearing debris from roads and critical infrastructure, said Rumbach.
“The aumaga were crucially important for emergency response because with such widespread devastation across the island, they were the de facto first responders,” he said. “Based in each village they are capable of responding to events locally and without having to be dispatched from larger population centers.”
The association of village women, aualuma, provided first aid, food and water to the victims.
Another traditional institution, the pulenu’u or village mayors, helped mitigate the destruction by sounding alarms in each community to warn of the impending tsunami. That action is credited with saving Amanave, a community of 300 that was able to evacuate before water destroyed virtually the entire village.
All the while, extended families known as aigas offered shelter, food and other aid to vulnerable individuals.
“Supporting indigenous institutions through disaster management policies and programs leverages existing networks with high levels of social capital, while simultaneously strengthening those institutions and making them relevant to contemporary challenges,” the study said. “It’s a `win-win’ scenario.”
Rumbach said FEMA’s recent turn toward more community-based disaster management efforts offers the chance to create more flexible response plans for diverse conditions, needs and priorities.
“In times of crisis these institutions played role of first responder all without specific training,” said Rumbach. “That response could be improved by being trained in CPR, evacuation of the elderly and other skills. But we could incorporate these kinds of traditional responses into FEMA.”
The lessons learned from American Samoa could be used in other island territories or traditional communities in the U.S.
“We often come in after disasters and set up whole new systems but in these places we could use institutions already in place,” Rumbach said. “Traditional communities have a lot of capacity.

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For Understanding Family Structure To Trauma: New Technology Is Yielding Bigger Data

Social media can do more than just entertain us and keep us connected. It also can help scientists better understand human behavior and social dynamics. The volume of data created through new technology and social media such as Facebook and Twitter is lending insight into everything from mapping modern family dynamics to predicting postpartum depression.

“By analyzing different types of social media, search terms, or even blogs, we are able to capture people’s thinking, communication patterns, health, beliefs, prejudices, group behaviors – essentially everything that has ever been studied in social and personality psychology,” says James Pennebaker, president of the Society of Personality and Social Psychology (SPSP), which is kicking off its annual conference today in Austin. “We can examine thousands, even hundreds of thousands of people at once or track them over time.”

Pennebaker of the University of Texas-Austin, whose work has explored the power of language in revealing our personality and behavior, is chairing a session today on the opportunities enabled by big data and new technology. No longer do research psychologists need to rely on traditional experimental designs, “running one upper middle class college student at a time,” he says. “We now have access to the world of social behavior in ways never imagined before.”

For example, a recent study by research scientists at Facebook analyzed 400,000 Facebook posts to determine differences in how parents talk to their children versus other friends and how they address their adult versus teen children. The posts, stripped of identifiable user information, showed that children’s communication with their parents decreases in frequency from age 13 on, but then rises when they move out. Counter to previous research on familial communication, they also found that being farther away from each other does not diminish how much parents and children talk on Facebook.

The study also found differences between how mothers and fathers use Facebook. Automatic language coding showed that mothers’ posts showed more emotion, using phrases like “poor baby” or “so proud of,” while fathers’ posts were more abstract, with phrases such as “keep it up” or “got your back.” Also, mothers were more likely to ask children to call them, while fathers talked more about shared interests, such as politics or sports.

“The Internet offers a tremendous opportunity to understand important social phenomena like family structure and also to help us explore how sharing information influences people’s emotional states and decision-making,” says Adam Kramer, a data scientist at Facebook. Kramer will be presenting such varying examples at the SPSP conference in Austin today.

Eric Horvitz, distinguished scientist and director of Microsoft Research lab in Redmond, Wash., has been analyzing data from Twitter and other online media to better understand and predict people’s health and well-being. “Large-scale data analyses generate insights about people – their mood, goals, intentions, health, and well-being – over both short and long periods of time,” he says.

In recent work, Horvitz and colleagues used Twitter to identify 376 new mothers who might be at risk of postpartum depression. They analyzed some 36,000 tweets during the 3 months leading up to the births and some 40,000 tweets for 3 months after the births to detect changes in mood and behavior. They looked at everything from networks of social engagement to word usage, using Pennebaker and colleagues’ measures of language shifts linked to downward mood shifts. For example, one potential indicator of postpartum depression is a shift from using third-person pronouns to first-person pronouns. Other indicators include a decrease in volume of tweets, a shrinking in the moms’ social networks, and use of words indicating negative mood.

Based on these factors, Horvitz’s team constructed a predictive model that can forecast significant postpartum shifts in mood in new mothers, using only observations available before the births. The model can identify mothers at risk of having such dramatic mood shifts as accurately as 70%. Next, the researchers need to test their model with women who have been already diagnosed with postpartum depression.

In other recent work, Horvitz and colleagues used participant reporting, along with pattern and network analysis, to examine the onset of major depressive episodes. His team first identified about 1,500 people with depression through an online assessment tool and then gave them the option of providing their Twitter handles. The researchers were then able to look at the Twitter feeds of the approximate 630 people who opted in to identify factors that predict the onset of major depressive disorders.

The hope, Horvitz says, is to develop new public health tools by leveraging the vast data available via social media with machine learning and linguistics analysis. He is also working on projects aimed understanding how women cope with breast cancer diagnoses, by analyzing patterns among anonymized Web search logs. Other work has explored how cognitive biases interact with search engine biases to fuel phenomena such as “cyberchondria” – the rise in anxiety about rare illnesses during Web searches of common, benign symptoms.

“We have reached an intriguing moment, perhaps unprecedented, when the data available to a handful of private companies – for example, Google, Facebook, Twitter, – could in principle make enormous impacts on social science research, especially social and personality psychology,” says J.B. Michel of the Institute for Quantitative Social Science at Harvard. With Erez Aiden, Michel recently used millions of books digitized by Google to build a scientific tool for measuring trends in our shared culture, history, and language going back hundreds of years.

“Never before could we in principle know so much about so many people over such long periods of time with such ease. But, these data are virtually unused in this way,” Michel says. “Addressing this divide is, in my mind, a transformative opportunity for the community of researchers interested in the human experience.”

Social media is not the only tool scientists have in gathering bigger data. Roxane Cohen Silver of the University of California, Irvine, has been using online surveys to study how people cope with trauma in the aftermath of disaster. “The ability to collect data online after national events is far more efficient and useful than the prior way of collecting post-disaster data from representative samples, which required collecting data by telephone using ‘random digit dialing,'” Silver says. She has studied the effects of 9/11 and more recently the Boston Marathon bombing, linking repeated media exposure in the early aftermath of the disaster to greater acute stress than being directly at or near the marathon.

Now Silver, with colleague Baruch Fischhoff from Carnegie Mellon University, is planning a project using a mobile app to study communities at-risk for severe weather events. “The goal is to collect assessments of risk, thoughts, and feelings before a hurricane, during the storm, and post-disaster reactions over time,” she says.

As technological capabilities grow, so too will the possibilities for research psychology. “Look around you,” Pennebaker says. “Ask your friends about their reliance on electronic communication. And then start figuring out ways to harness this technology to understand the world around us.”

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New Construction Robots Inspired By Building Habits Of Termites

[ Watch the Video: Termites Inspire Robots ]

redOrbit Staff & Wire Reports – Your Universe Online

Inspired by the way termites are capable of building mounds that are hundreds of times their size without detailed plans, researchers from the Wyss Institute for Biologically Inspired Engineering and the Harvard School of Engineering and Applied Sciences (SEAS) have developed robots capable of mimicking the behavior.

The TERMES system, as it is known, was developed by a team of computer scientists and engineers and essentially serves as an autonomous mechanical construction crew. Unlike human builders, the robots require no blueprints or detailed instructions, no supervisor, and no centralized communications director – similar to how termites take cues from one another and from their environment to place individual dirt clumps and complete a structure.

“Termites are what inspired this whole research topic for us,” explained lead investigator and Wyss Institute researcher Justin Werfel. “We learned the incredible things these tiny insects can build and said: Fantastic. Now how do we create and program robots that work in similar ways but build what humans want?”

The technique through which termites use the information around them is known as stigmergy, and Werfel and his colleagues adapted the approach to create algorithms which allowed the TERMES project robots to behave in a similar manner. Their results were presented this week during the 2014 AAAS Annual Meeting, as well as in Friday’s edition of the journal Science.

Using sensors, the bots move along a grid, lift bricks and deposit them in new locations, the researchers said. They are capable of building towers, castles and pyramids out of foam bricks, and also demonstrated their ability to build staircases to reach higher levels and add bricks where needed. Ultimately, the developers believe that the robots could be used to build structures on Mars or defend against natural disasters.

“A long-term vision is for robot teams like this to build full-scale structures for human use, maybe with particular utility in settings where it’s difficult or dangerous for humans to work (e.g., building shelters after an earthquake or habitats underwater or on other planets),” Werfel said. “While that’s likely a long way out, a shorter-term application could be something like building levees out of sandbags for flood protection.”

Each robot follows a series of simple instructions to work independently, functioning together towards a common goal but without knowing what tasks any of the other machines are performing at the same time. If one robot breaks down, the others are unaffected, and the technology is scalable, meaning that the same instructions can be executed regardless of how many robots are working on a given structure.

According to Werfel, each of the machines is given just two basic types of instructions. “The rules that are the same for any structure the robots build, and the ‘traffic laws’ that correspond to the specific structure,” he said. “The [traffic laws] tell robots at any site which sites they’re allowed to go to next: traffic can only flow in one direction between any two adjacent sites, which keeps a flow of robots and material moving through the structure.”

“We co-designed robots and bricks in an effort to make the system as minimalist and reliable as possible,” added co-author Kirstin Petersen, who spearheaded the design and construction of the machines. “Not only does this help to make the system more robust; it also greatly simplifies the amount of computing required of the onboard processor. The idea is not just to reduce the number of small-scale errors, but more so to detect and correct them before they propagate into errors that can be fatal to the entire system.”

Image 2 (below): Harvard graduate student Kirstin Petersen and staff scientist Justin Werfel admire a termite mound in Namibia. Credit: Self-Organizing Systems Research Group, Harvard SEAS

Advanced Techniques Yield New Insights Into Ribosome Self-Assembly

Ribosomes, the cellular machines that build proteins, are themselves made up of dozens of proteins and a few looping strands of RNA. A new study, reported in the journal Nature, offers new clues about how the ribosome, the master assembler of proteins, also assembles itself.

“The ribosome has more than 50 different parts – it has the complexity of a sewing machine in terms of the number of parts,” said University of Illinois physics professor Taekjip Ha, who led the research with U. of I. chemistry professor Zaida Luthey-Schulten and Johns Hopkins University biophysics professor Sarah Woodson. “A sewing machine assembles other things but it cannot assemble itself if you have the parts lying around,” Ha said. “The ribosome, however, can do that. It’s quite amazing.”

In 2000, scientists published precise atomic structures of intact ribosomes (a feat that won them a 2009 Nobel Prize in chemistry) and for decades researchers have delved into the mechanics of ribosome function. But scientists have much to learn about how the ribosome itself is built from its component parts, Luthey-Schulten said.

Solving the atomic structure was a huge step forward “that tells us what the ribosome looks like once it’s assembled,” she said. “But it doesn’t tell you anything about how it gets there, how all these parts come together.”

All ribosomes consist of two subunits, each a cluster of precisely folded proteins and RNA. The team focused on the small ribosomal subunit of the E. coli bacterium. It is made up of about 20 proteins and a ribosomal RNA (known as 16S).

The researchers labeled one of those ribosomal proteins. Known as S4, it is thought to be the first to interact with the 16S RNA during assembly. They also labeled two sites on the 16S RNA. Each label fluoresced a different color, and was designed to glow more brightly when in close proximity to another label (a technology known as FRET). These signals offered clues about how the RNA and proteins were interacting.

The team was most interested in a central region of the 16s RNA because it contains signature sequences that differentiate the three cellular “domains,” or superkingdoms, of life. Previous studies suggested that this region also was key to the RNA-protein interactions that occur in the earliest stages of ribosome assembly.

Using a “computational microscope,” the team compared data from their FRET experiments with an all-atom simulation of the protein and RNA interaction. Their analysis revealed that the S4 protein and the 16S ribosomal RNA were a surprisingly “dynamic duo,” Ha said. The protein constrained the RNA somewhat, but still allowed it to undulate and change its conformation.

The team found that the S4 protein tends to bind to the RNA when the RNA takes on an unusual conformation – one not seen in the fully assembled ribosome. This was a surprise, since scientists generally assume that ribosomal proteins lock RNA into its final, three-dimensional shape.

“We found that the S4 and RNA complex is not static,” Ha said. “It actually is dynamic and that dynamism is likely to allow binding of the next protein” in the sequence of ribosome assembly.

“Once the S4 binds, it induces other conformational changes that allow the binding sites for other proteins to appear,” he said. “So the binding site for the third protein doesn’t appear until after the second protein is there.”

This intricate dance of molecules leading to the assembly of ribosomes occurs very fast, Luthey-Schulten said. “You can go from as few as 1,000 to 30,000 ribosomes in a bacterial cell during its cell cycle,” she said. “More than 80 percent of the RNA that’s in the cell is in the ribosomes.”

Knowing how the ribosome is put together offers new antibiotic targets, said Ha, who is a Howard Hughes Medical Institute investigator and a co-director of the Center for the Physics of Living Cells at Illinois.

“Instead of waiting until your enemy has fully assembled its army, you want to intervene early to prevent that from happening,” he said. “We know that this protein/RNA region has unique signatures in bacteria, so maybe we can target this process while keeping the human ribosome intact.”

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Well-Child Doctor Visits Lead To Higher Risk Of Illness: Study

Brett Smith for redOrbit.com – Your Universe Online

A new study from researchers at the University of Iowa presents parents with an interesting dilemma – bringing a healthy child in for a check-up or vaccination might be the right thing to do for their health, but it could expose them to a higher risk of illness.

According to the study, which was published in the journal Infection Control and Hospital Epidemiology, “well child” visits to the doctor could be causing more than 700,000 potentially avoidable flu-like illnesses each year.

“Well child visits are critically important. However, our results demonstrate that healthcare professionals should devote more attention to reducing the risk of spreading infections in waiting rooms and clinics,” said Dr. Phil Polgreen, an epidemiologist at the University of Iowa. “Infection control guidelines currently exist. To increase patient safety in outpatient settings, more attention should be paid to these guidelines by healthcare professionals, patients, and their families.”

In the study, the researchers used data culled from the Agency for Healthcare Research and Quality’s (AHRQ) Medical Expenditure Panel Survey from 1996 to 2008 to look at the healthcare trends of nearly 85,000 families. Included in the evaluation were demographic, office-based, hospital, and outpatient case records. After controlling for confounding factors, such as demographics, the authors learned that well-child visits for patients younger than six years old boosted the odds of a flu-like illness in these children or their families during the following two weeks by 3.2 percent.

The study authors conclude that the more than 700,000 avoidable cases of illness each year result in over $490 million in direct and indirect costs.

In an editorial published alongside the study, Dr. Lisa Saiman, a pediatrician from Columbia University Medical Center, wrote that “the true cost of flu-like illnesses are much higher since only a fraction result in ambulatory visits and many more cases are likely to result in missed work or school days.”

“Furthermore, these flu-like illness visits are associated with inappropriate antimicrobial use,” she added.

The authors noted that their study emphasized the importance of infection reduction and management. They suggested that relevant healthcare facilities follow infection mitigation guidelines, which include maintaining cleaning regimens, practicing proper cough etiquette, and following hand hygiene rules.

Sailman wrote that there may be some resistance among healthcare staff to changing routines or recognizing bad habits.

“One can imagine the complexity of implementing infection prevention and control practices to prevent (flu-like illness) in a pediatric primary care setting, and numerous barriers exist to do so,” she wrote. “These include knowledge, attitude, and practice barriers.”

“Attitude barriers experienced by staff may include disagreement with the recommendations, lack of confidence that infection prevention and control practices can be implemented in the ambulatory care setting, lack of belief that the practices may improve their patients’ outcomes, and the inertia of current practice,” she continued. “Practice barriers may be particularly relevant for ambulatory settings and include lack of time, space, money, administrative support, and/or ancillary personnel.”

Polgreen noted that infections can easily spread if all proper steps are not taken.

“Even with interventions, such as the restricted use of communal toys or separate sick and well-child waiting areas, if hand-hygiene compliance is poor, and potentially infectious patients are not wearing masks, preventable infections will continue to occur,” he said.

MIT Develops Unprecedented System That Lets Robots Work Together

redOrbit Staff & Wire Reports – Your Universe Online

Researchers at MIT have developed a new system that combines simple control programs to enable fleets of robots or other “multiagent systems” to collaborate in extraordinary ways.

Due to the difficulty of designing control programs for “multiagent systems” – groups of robots or networks of devices with different functions – engineers have typically restricted themselves to scenarios in which reliable information about the environment can be presumed, or to relatively simple collaborative tasks that can be clearly specified in advance.

However, researchers from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) will soon present a new system that stitches existing control programs together to allow multiagent systems to collaborate in much more sophisticated ways.

The engineers, who will present their system at the International Conference on Autonomous Agents and Multiagent Systems in May, said their work focuses on mitigating uncertainty. This could include, for example, factoring in the odds that a particular communications link might drop, or that an algorithm might inadvertently steer a robot into a dead end. The new system would account for this uncertainty, and automatically circumventing these events.

For small collaborative tasks, the system can guarantee that its combination of programs is optimal, and will yield the best possible results given the uncertainty of the environment and the limitations of the programs themselves.

The researchers said they are currently testing their system in a simulation of a warehousing application, where small groups of iRobot Creates – programmable robots that have the same chassis as the Roomba vacuum cleaner – are required to retrieve arbitrary objects from indeterminate locations, collaborating as needed to transport heavy loads.

“In [multiagent] systems, in general, in the real world, it’s very hard for them to communicate effectively,” said Christopher Amato, a postdoc in CSAIL and first author of a paper about the work.

“If you have a camera, it’s impossible for the camera to be constantly streaming all of its information to all the other cameras. Similarly, robots are on networks that are imperfect, so it takes some amount of time to get messages to other robots, and maybe they can’t communicate in certain situations around obstacles,” he said in a statement.

An agent may not even have perfect information about its own location, such as which aisle of the warehouse it is actually in, Amato added.

“When you try to make a decision, there’s some uncertainty about how that’s going to unfold,” he said.

“Maybe you try to move in a certain direction, and there’s wind or wheel slippage, or there’s uncertainty across networks due to packet loss. So in these real-world domains with all this communication noise and uncertainty about what’s happening, it’s hard to make decisions.”

The new MIT system, which Amato developed alongside co-authors Leslie Kaelbling, professor of Computer Science and Engineering at MIT, and fellow posdoc George Konidaris, takes three inputs. One is a set of low-level control algorithms, or “macro-actions,” which control agents’ behaviors collectively or individually. The second is a set of statistics about those programs’ execution in a particular environment, while the third is a structure for valuing different outcomes.

The system would take these inputs, and decide how to best combine macro-actions to maximize the system’s value function. It might use all the macro-actions, or only a tiny subset, and perhaps in ways that a human designer would never have imagined.

The researchers gave an example of a scenario in which each robot has a small bank of colored lights that it can use to communicate with its counterparts if a wireless link goes down.

“What typically happens is, the programmer decides that red light means go to this room and help somebody, green light means go to that room and help somebody,” Amato explained. “In our case, we can just say that there are three lights, and the algorithm spits out whether or not to use them and what each color means.”

The researchers’ work frames the problem of multiagent control as something known as a partially observable Markov decision process, or POMDP.

“POMDPs, and especially Dec-POMDPs, which are the decentralized version, are basically intractable for real multirobot problems because they’re so complex and computationally expensive to solve that they just explode when you increase the number of robots,” said multirobot systems expert Nora Ayanian, an assistant professor of computer science at the University of Southern California.

“So they’re not really very popular in the multirobot world,” she added.

“Normally, when you’re using these Dec-POMDPs, you work at a very low level of granularity,” said Ayanian in a statement. “The interesting thing about this paper is that they take these very complex tools and kind of decrease the resolution. This will definitely get these POMDPs on the radar of multirobot-systems people.”

“It’s something that really makes it way more capable to be applied to complex problems,” she concluded.

Common Pizza Spice Can Launch Brutal Attack On Nasty Norovirus

[ Watch the Video: An Unorthodox, Spicy Cure For Norovirus ]

Brett Smith for redOrbit.com – Your Universe Online

New research from the University of Arizona has found that pizza contains an effective weapon against the norovirus, which causes a nasty illness marked by vomiting and diarrhea.

According to a report published Wednesday in the Journal of Applied Microbiology, carvacrol – the substance in oregano oil that gives pizza its distinctive smell – effectively breaks down the tough, protective exterior of the norovirus.

Often the cause of food-borne epidemics, the norovirus is especially problematic in confined living quarters such as hospitals, cruise ships, and schools. Even though the disease is unpleasant, most people get better within a few days. However, the virus can be deadly for people with an existing significant medical problem.

“Carvacrol could potentially be used as a food sanitizer and possibly as a surface sanitizer, particularly in conjunction with other antimicrobials,” said study author Kelly Bright. “We have some work to do to assess its potential but carvacrol has a unique way of attacking the virus, which makes it an interesting prospect.”

Using mice to model the disease, the scientists learned that carvacrol seemed to act directly on the virus capsid, a robust layer of proteins that encompasses the virus, causing it to disintegrate. This action would give a different antimicrobial the chance to enter the sensitive interior of the virus and destroy it. The researchers also noted that carvacrol is relatively slow acting and suggested that a routine cleaning regimen would offer a long-lasting antimicrobial layer on surfaces.

One main benefit of carvacrol is that it acts on the external proteins of the virus, meaning it is improbable that norovirus would ever build up a resistance. A carvacrol disinfectant would also be safe, non-corrosive and it wouldn’t produce any harmful by-products. This makes it appreciably attractive for use in highly-populated settings including schools, medical centers, long-term care facilities and substance rehabilitation centers.

Unfortunately, the researchers said a steady diet of pizza would not provide enough carvacrol to offer significant protection against the norovirus.

According to research presented at the IDWeek 2013 infectious diseases conference in October, an experimental norovirus vaccine has been found to reduce the main symptoms of the gastrointestinal infection by more than half.

The study team conducted a randomized, multi-center trial featuring 98 individuals who agreed to drink water contaminated with a significant amount of the virus. Fifty of those participants were injected with the vaccine, and the remaining 48 were given a placebo injection. Neither group knew in advance which group had received the vaccine and which group had not.

Twenty-six members of the vaccine group (52 percent) were infected, as were 29 members (60 percent) of those in the placebo group. Among those who did not receive the vaccine, 20 members (42 percent) suffered from mild, moderate or severe vomiting and/or diarrhea. In comparison, 10 (20 percent) of the vaccine group experienced those symptoms – a reduction of 52 percent.

“Norovirus truly is a global issue and most if not everyone has experienced it to some degree. The results of our study are promising and our next step is to test this vaccine in a real-world setting,” said lead researcher David I. Bernstein of Cincinnati Children’s Hospital Medical Center.

Juggling Reveals Clues On Role Of Sensory Feedback In Running

[ Watch the Video: Juggling For Prosthetics Research ]

redOrbit Staff & Wire Reports – Your Universe Online

The act of juggling is shedding new light on the role our vision and sense of touch have in helping control the way we engage in rhythmic movements such as running, researchers from John Hopkins University reported in the Journal of Neurophysiology.

The study’s findings could someday aid in the treatment of people with neurological diseases, and help improve prosthetic limbs, the researchers said.

The Johns Hopkins engineers, led by Noah Cowan, associate professor of mechanical engineering, noted that juggling involves repeated rhythmic motions to keep multiple balls aloft. These motions are similar to forms of rhythmic movement commonly seen in the animal world, where effective locomotion is critical.

“It turns out that the art of juggling provides an interesting window into many of the same questions that you try to answer when you study forms of locomotion, such as walking or running,” said Cowan, an amateur juggler since he was a teenager.

“In our study, we had participants stand still and use their hands in a rhythmic way. It’s very much like watching them move their feet as they run. But we used juggling as a model for rhythmic motor coordination because it’s a simpler system to study.”

[ Watch the Video: Juggling Study Shows How Senses Help Us Run ]

Cowan and his team wanted to examine how the brain uses vision and the sense of touch to control this type of behavior, so they set up a simple virtual juggling scenario. Study participants held a physical paddle connected to a computer, and were instructed to bounce an on-screen ball repeatedly up to a target area between two lines, also drawn on the monitor.

In some trials, the participants had only their vision to guide them, while in others they also received a brief impulse on their real-world paddle whenever the digital ball hit the onscreen paddle. This mimicked the sensation a participant would feel if a real ball had actually struck the paddle they were holding.

With the added touch sensation, or haptic feedback, the participants made about half as many errors in the task, the study revealed.

“We have a pretty good understanding as to why,” said Cowan.

“One of the tricky challenges in juggling is catching a rhythm; that is, getting yourself entrained with the movement of the ball. It’s about timing your own action with the action in the environment. When you get the pulse of haptic feedback at the exact moment the ball hits the paddle, it give you a precise sense of the timing for the juggling pattern that you’re trying to achieve.”

M. Mert Ankarali, a Johns Hopkins mechanical engineering doctoral student who was lead author of the study, said our sense of touch provides us with important timing cues.

“The human nervous system gets feedback all of the time from our sense of vision. But the important thing about the sense of touch while juggling is that we get a precise timing cue that complements the continuous visual feedback. This timing cue is very important for us to get the rhythm of the juggling task.”

Although adding the touch feedback did not appear to improve the participants’ ability to correct for any juggling errors made while trying to hit the ball into the target zone, it did enable the participants to make fewer errors overall.

“The haptic sensation is just a tiny bit of feedback that’s provided once per juggling cycle,” Cowan explained.

“Yet that tiny bit of information seems to be critical for people to improve their juggling performance. We think that’s because while vision provides excellent spatial and positioning information, the haptic information provides very important timing information.”

When humans and animals walk or run, their sense of touch plays a vital role, Cowan said. As the runner’s feet touch the ground, they alert the nervous system to adjust the movement of the legs to accommodate changes in the running surface. The brain’s ability to instantly integrate information coming from both the eyes and the sense of touch is a critical part of successful running, juggling and other repetitive movements, he said.

The researchers said that future studies of the connection between sensory feedback, timing and limb movements could improve understanding about how some neurological diseases might disrupt the brain’s timing of movements by arms and legs. Future findings may also assist engineers in making better touch-sensitive artificial limbs and robots.

Chronic Stress Generates Long-Term Changes In The Brain Which Could Lead To Mental Illness

April Flowers for redOrbit.com – Your Universe Online
Chronic stress generates long-term changes in the brain, according to a new study from the University of California, Berkeley. These changes may explain why people suffering from chronic stress are prone to mental problems such as anxiety and mood disorders.
The findings, published in the journal Molecular Psychiatry, might lead to new therapies to reduce the risk of developing mental illness after stressful events.
Robert Sanders of UC Berkeley reports doctors have known for a while that people with stress-related illnesses, such as post-traumatic stress disorder (PTSD), have abnormalities in the brain. These abnormalities include differences in the amount of gray matter versus white matter. Grey matter is mainly formed of cells — neurons, which store and process information, and support cells called glia. White matter, in contrast, consists mainly of axons, which create a network of fibers that interconnect neurons, and gets its name from the white, fatty myelin sheath that surrounds the axons and speeds the flow of electrical signals from cell to cell.
Researchers are only now starting to unravel the mystery of how chronic stress creates these long-lasting changes in brain structure.
Daniela Kaufer, UC Berkeley associate professor of integrative biology, and a team of colleagues performed a series of experiments, discovering that chronic stress generates more myelin-producing cells and fewer neurons than normal. The delicate balance and timing of communication within the brain is disrupted by this resulting excess of myelin — and thus white matter — in some areas of the brain.
“We studied only one part of the brain, the hippocampus, but our findings could provide insight into how white matter is changing in conditions such as schizophrenia, autism, depression, suicide, ADHD and PTSD,” Kaufer told Sanders.
Memory and emotions are regulated by the hippocampus, which also plays a role in various emotional disorders.
Kaufer’s findings, for example, suggest a mechanism that might explain some changes in brain connectivity in individuals with PTSD. Kaufer said that it is easy to imagine that PTSD patients could develop a stronger connectivity between the hippocampus and the amygdala — which is the seat of the brain’s fight of flight response — and a lower than average connectivity between the hippocampus and the prefrontal cortex — which moderates our responses to stimuli.
“You can imagine that if your amygdala and hippocampus are better connected, that could mean that your fear responses are much quicker, which is something you see in stress survivors,” she said. “On the other hand, if your connections are not so good to the prefrontal cortex, your ability to shut down responses is impaired. So, when you are in a stressful situation, the inhibitory pathways from the prefrontal cortex telling you not to get stressed don’t work as well as the amygdala shouting to the hippocampus, ‘This is terrible!’ You have a much bigger response than you should.”
Kaufer is involved in a study to test her hypothesis in PTSD patients, as well as continuing to study brain changes in rodents subjected to chronic stress or adverse environments early in life.
Kaufer’s lab conducts research on the molecular and cellular effects of acute and chronic stress. This study focused on neural stem cells in the hippocampus of the brains of adult rats. Previously, these stem cells were thought to mature only into neurons or a type of glial cell called an astrocyte. Kaufer’s team found, however, that chronic stress also made stem cells in the hippocampus mature into another type of glial cell called an oligodendrocyte, which produces myelin that sheaths nerves cells.
The team demonstrated their findings in rats and cultured rat brain cells, suggesting a key role for oligodendrocytes in long-term and perhaps permanent changes in the brain that could set the stage for later mental problems. These cells also help form synapses — areas where one cell communicates with another – and help control the growth pathway of axons, which make those synapse connections.
Kaufer said that the fact that chronic stress also decreases the number of stem cells that mature into neurons could suggest an explanation for how chronic stress also affects learning and memory.
Kaufer’s research team is continuing their investigations with experiments designed to determine how stress in infancy affects the brain’s white matter, and whether chronic early-life stress decreases resilience later in life. They are also examining the effects of therapies, ranging from exercise to antidepressant drugs, that reduce the impact of stress and stress hormones.
Image 2 (below): Myelin is stained blue in this cross section of a rat hippocampus. Myelin, which speeds electrical signals flowing through axons, is produced by oligodendrocytes, which increase in number as a result of chronic stress. New oligodendrocytes are shown in yellow. Credit: Aaron Friedman and Daniela Kaufer

Relationships In The Digital Age: How Technology Affects Couples

April Flowers for redOrbit.com – Your Universe Online

The internet, and especially social media, is having an impact on American couples as technology becomes more deeply integrated into people’s lives.

A new study published by Pew Internet & American Life Project reveals that couples are feeling both the positive and negative effects of digital communication tools in their relationships.

The researchers found that 27 percent of American adults online who are married or in committed relationships report that the internet has had an impact on their relationships. A majority report that the impact has been positive. However, in some relationships, technology has been seen as a negative source of distraction. For example, 25 percent of cell phone users in serious relationships report that the phone distracts their spouse or partner when they are alone together.

The data was collected from telephone interviews with 2,252 adults aged 18 and older, conducted by Princeton Survey Research Associates International from April 17 to May  19, 2013. The interviews — 1,125 by landline, 1,125 by cell phone, including 571 without landlines — were conducted in both English and Spanish.

Technology has changed the face of many relationships, affecting the way the couples communicate, grow closer, plan, fight and make up. The findings examine the role of technology in the lives of married or partnered adults, exploring both the positive and negative effects.

This is the second of two reports about the impact of technology — the internet, social media and mobile phones, specifically — on online dating and romantic relationships. The companion report focuses on the internet’s impact on meeting and dating, rather than couples.

Kaspersky Labs Warns Of State-Sponsored Spanish Language Malware

Peter Suciu for redOrbit.com – Your Universe Online

On Monday security researchers at Kaspersky Labs announced the discovery of cyber-espionage malware, which may have targeted governments and companies in 31 countries. Dubbed “The Mask,” or “Careto,” it is believed to be one of the first Spanish language attacks to have been discovered – yet it may have been active since 2007.

This particular malware is quite insidious in that it can siphon sensitive documents from infected computers. It is also unusually complex and has versions that may have been targeting mobile phones and tablets, including those running Apple’s iOS and Google’s Android operating systems. Kaspersky noted that this is a particularly complex toolset that is extremely sophisticated and includes malware, rootkit, bootkit and is even found in Mac OS X and Linux versions.

The malware has been targeting government institutions including diplomatic offices and embassies, as well as energy companies (oil and gas), research facilities and even activist websites. Kaspersky said they found that victims have been uncovered in 31 countries around the world from the Middle East, Europe, Africa and the Americans.

In the Executive Summary of the report, Kaspersky noted: “The Mask is an advanced threat actor that has been involved in cyber-espionage operations since at least 2007. The name ‘Mask’ comes from the Spanish slang word ‘Careto’ (‘Ugly Face’ or ‘Mask’), which the authors included in some of the malware modules.”

It added that when active in a victim system, “The Mask can intercept network traffic, keystrokes, Skype conversations, PGP keys, analyse WiFi traffic, fetch all information from Nokia devices, screen captures and monitor all file operations.”

The malware reportedly collects information from documents, and this can include encryption keys, VPN configurations, SSH keys and RDP files. More than 380 unique victims over the course of the last five years have been discovered.

The question now is who might be beyond the Mask? Kaspersky researchers believe this could be state-sponsored malware.

“Several reasons make us believe this could be a nation-state sponsored campaign,” said Costin Raiu, director of the Global Research and Analysis Team (GReAT) at Kaspersky Lab. “First of all, we observed a very high degree of professionalism in the operational procedures of the group behind this attack. From infrastructure management, shutdown of the operation, avoiding curious eyes through access rules and using wiping instead of deletion of log files. These combine to put this APT ahead of Duqu in terms of sophistication, making it one of the most advanced threats at the moment. This level of operational security is not normal for cyber-criminal groups.”

The Telegraph noted that the suspected involvement of a Spanish-speaking nation is most unusual, as past sophisticated cyber spying operations have been linked to the United States, China, Russia and Israel.

The researchers at Kaspersky believe the Mask has Spanish roots because of Spanish words found in the malware – notably “careto” – as well as slang terms. This could have been added to throw researchers off the trail, however.

“This is all speculation since these could be false flags,” Cesar Cerrudo, chief technology officer at security firm IOactive, told Mashable. “Others could have created the malware and put those strings on purpose to mislead — I wouldn’t discount that.”

While the malware did appear to use phishing emails that included links that pointed to Spanish news sites including El Mundo and El Pais, fake links also pointed to The Guardian, The Washington Post and Time. This suggests that the malware authors were going for a large target audience.

Whoever is behind The Mask so far has yet to be revealed.

Smoking Not Only Bad For Lungs, But Also For Breasts: Study

[ Watch the Video: Smoking Can Also Give You Breast Cancer ]

Brett Smith for redOrbit.com – Your Universe Online

Cigarette smoking has frequently been linked to cancers of the respiratory system, but a new study has found that smoking can also greatly increase the risk of a certain breast cancer in women.

According to a study recently published in the journal Cancer, young women who smoke a pack per day for a decade or longer have a much greater risk of having the most common kind of breast cancer.

While some past reports have established the relationship between smoking and elevated breast cancer risk among young women, not many have looked into risks based on different subtypes of breast cancer.

“I think there is a growing appreciation that breast cancer is not just one disease and there are many different subtypes,” study author Dr. Christopher Li, of the Fred Hutchinson Cancer Research Center in Seattle, told Reuters. “In this study, we were able to look at the different molecular subtypes and how smoking affects them.”

To investigate, the study team recruited nearly 780 patients with estrogen receptor positive breast cancer and just over 180 patients with triple-negative breast cancer. Estrogen receptor positive breast cancer is the most typical subtype of breast cancer, while triple-negative breast cancer is less frequent but can be more aggressive. Female participants were 20 to 44 years old and were diagnosed between 2004 and 2010 in the Seattle-Puget Sound metropolitan area in Washington State. The study also included nearly 940 participants who did not have a cancer diagnosis.

Overall, study participants who had smoked were about 30 percent more likely to develop any type of breast cancer, compared to non-smokers. The scientists also found that participants who were smokers during the study – or had recently quit and had been smoking a pack daily for at least 10 years – had a 60 percent elevated risk of estrogen receptor positive breast cancer. The researchers did not find a connection between triple-negative breast cancer and smoking.

The researchers speculated that some of the substances found in cigarettes could be acting like estrogen and disrupt that hormonal cycle, which would explain the elevated risk of estrogen receptor-positive breast cancer.

“There are so many different chemicals in cigarette smoke that can have so many kinds of effects,” Li said.

“The health hazards associated with smoking are numerous and well known,” he added. “This study adds to our knowledge in suggesting that with respect to breast cancer, smoking may increase the risk of the most common molecular subtype of breast cancer but not influence risk of one of the rarer, more aggressive subtypes.”

While smoking is a personal choice that could affect the risk of developing cancer, some people are genetically predisposed to contracting the disease. A recent poll from the University of Utah’s Huntsman Cancer Institute found that 34 percent of respondents would not request genetic testing to predict their likelihood of developing a genetic cancer – even if the cost of the testing was not an issue.

The poll also found that 35 percent of respondents would be extremely or very likely to seek aggressive preventive treatment, such as a mastectomy, if they had a family history of cancer and genetic testing indicated a high genetic risk for the disease.

Australian Astronomers Discover Oldest Star With The SkyMapper Telescope

Australian National University

A team led by astronomers at The Australian National University has discovered the oldest known star in the Universe, which formed shortly after the Big Bang 13.7 billion years ago.

The discovery has allowed astronomers for the first time to study the chemistry of the first stars, giving scientists a clearer idea of what the Universe was like in its infancy.

“This is the first time that we’ve been able to unambiguously say that we’ve found the chemical fingerprint of a first star,” said lead researcher, Dr Stefan Keller of the ANU Research School of Astronomy and Astrophysics.

“This is one of the first steps in understanding what those first stars were like. What this star has enabled us to do is record the fingerprint of those first stars.”

The star was discovered using the ANU SkyMapper telescope at the Siding Spring Observatory, which is searching for ancient stars as it conducts a five-year project to produce the first digital map the southern sky.

The ancient star is around 6,000 light years from Earth, which Dr Keller says is relatively close in astronomical terms. It is one of the 60 million stars photographed by SkyMapper in its first year.

“The stars we are finding number one in a million,” says team member Professor Mike Bessell, who worked with Keller on the research.

“Finding such needles in a haystack is possible thanks to the ANU SkyMapper telescope that is unique in its ability to find stars with low iron from their color.”

Dr Keller and Professor Bessell confirmed the discovery using the Magellan telescope in Chile.

The composition of the newly discovered star shows it formed in the wake of a primordial star, which had a mass 60 times that of our Sun.

“To make a star like our Sun, you take the basic ingredients of hydrogen and helium from the Big Bang and add an enormous amount of iron – the equivalent of about 1,000 times the Earth’s mass,” Dr Keller says.

“To make this ancient star, you need no more than an Australia-sized asteroid of iron and lots of carbon. It’s a very different recipe that tells us a lot about the nature of the first stars and how they died.”

Dr Keller says it was previously thought that primordial stars died in extremely violent explosions which polluted huge volumes of space with iron. But the ancient star shows signs of pollution with lighter elements such as carbon and magnesium, and no sign of pollution with iron.

“This indicates the primordial star’s supernova explosion was of surprisingly low energy. Although sufficient to disintegrate the primordial star, almost all of the heavy elements such as iron, were consumed by a black hole that formed at the heart of the explosion,” he says.

The result may resolve a long-standing discrepancy between observations and predictions of the Big Bang.

The discovery was published in the latest edition of the journal Nature.

Image 2 (below): Dr. Stephen Keller is shown working in the SkyMapper Telescope at the Australian National University’s Siding Spring Observatory. Credit: Martyn Pearce, ANU

New Hearing Implant Uses Less Power, No External Hardware

[ Watch the Video: The Sound Of Innovation For Deafness ]

Lawrence LeBlond for redOrbit.com – Your Universe Online

Hundreds of thousands of deaf, or near-deaf, people around the world have benefited from cochlear implants. While these devices are undoubtedly a good thing, the hardware to make them work has been somewhat of a pain.

Cochlear implants typically require a small transmitter affixed to the skull with a wire dangling down to a microphone, as well as a battery pack that must be worn around the patient’s ear. While the pros may seemingly outweigh the cons, some people may opt to not use the devices at all.

Now, researchers from MIT’s Microsystems Technology Laboratory (MTL), working with physicians from Harvard Medical School and the Massachusetts Eye and Ear Infirmary (MEEI), may have a solution to this problem.

The team has developed a new, low-power signal-processing chip that works with a cochlear implant and requires no external hardware. The researchers say the implant could work for eight hours between charges, which would be done wirelessly without the need for an unsightly battery pack on the outer ear.

Presenting the developments in a paper at this week’s International Solid-State Circuits Conference, lead author Marcus Yip, PhD, and coauthors Rui Jin and Nathan Ickes, both of MIT’s Department of Electrical Engineering and Computer Science, will exhibit a prototype charger at the conference that plugs into a smartphone and can recharge the chip in two minutes.

“The idea with this design is that you could use a phone, with an adaptor, to charge the cochlear implant, so you don’t have to be plugged in,” Anantha Chandrakasan, the Joseph F. and Nancy P. Keithley Professor of Electrical Engineering and corresponding author on the new paper, said in a statement. “Or you could imagine a smart pillow, so you charge overnight, and the next day, it just functions.”

Along with losing the bulky battery pack, the team show that the external microphone is no longer needed. Instead, the chip will implement the natural microphone of the middle ear, which is almost always intact in cochlear-implant patients.

The newly designed chip uses technology from another common device known as the middle-ear implant. The ossicles – three delicate bones (malleus, incus, and the stapes) located in the middle ear – convey vibrations of the eardrum to the small chamber (cochlea) within the inner ear and converts acoustic sounds to electrical signals. The cochlea remains functional in patients with middle-ear implants; however, the stapes doesn’t vibrate with enough force to stimulate the auditory nerve. The middle-ear implant uses a tiny sensor that detects vibrations from the ossicles and an actuator that helps the stapes work accordingly.

A key component of the new device was lower power consumption. Chandrakasan and his team at MTL specialize in low-power chips and the new device employs several tricks developed in his lab over the years. But the team have also developed a new signal-generating circuit that reduces power consumption of the chip by an additional 20 to 30 percent.

With a developed prototype in their hands, the next thing to do was to test it.

MEEI researchers Konstantina Stankovic, MD, PhD, an ear surgeon who co-led the study with Chandrakasan, and Don Eddington, PhD, tested the new device on four patients who were already using cochlear implants, finding that the new device had no effect on their ability to hear. Then, along with Heidi Nakajima, MD, PhD, another MEEI collaborator, the team tested the chip and sensor on a human cadaver. They showed that both the chip and sensor are able to pick up and process speech played into the ear of the cadaver.

“It’s very cool,” said Lawrence Lustig, MD, director of the Cochlear Implant Center at the University of California at San Francisco. “There’s a much greater stigma of having a hearing loss than there is of having a visual loss. So people would be very keen on losing the externals for that reason alone. But then there’s also the added functional benefit of not having to take it off when you’re near water or worrying about components getting lost or broken or stolen. So there are some important practical considerations as well.”

While the cons of the existing technology insist on the patient wearing somewhat unsightly external hardware, Lustig noted that the new technology isn’t necessarily less-invasive. The new cochlear implant requires a more complex surgery than what the existing implants do.

“A current cochlear-implant operation takes an hour, hour and a half,” he said. “My guess is that the first surgeries will take three to four hours.”

“As we get better and better and better, that time will shorten,” Lustig noted. “And three to four hours is still a relatively straightforward operation. I don’t anticipate putting a lot of extra risk into the procedure.”

Researchers Uncover Link Between Birth Order And Being Overweight

redOrbit Staff & Wire Reports – Your Universe Online

First-born children could be more likely than their younger siblings to be overweight later on in life, researchers from the University of Auckland in New Zealand claim in research appearing in Thursday’s edition of the journal Scientific Reports.

The study found that children who were born first into a family were approximately 7 kilograms heavier and had a higher BMI than those born second, according to Helen Briggs of BBC News. Furthermore, they were found to be more resistant to insulin, which could lead to other health issues.

In the study, Dr. Wayne Cutfield, director of the university’s Liggins Institute and a professor of pediatric endocrinology, and his colleagues studied 50 overweight but otherwise healthy men between the ages of 39 to 51. They found that first-born men weighed more than second-born men, tended to be heavier for their height and were also roughly one-third less sensitive to insulin.

“The study… is the first of its kind in mid-life,” said New Zealand Herald reporter Martin Johnston. “It follows Liggins’ findings last year in children that those born first had higher blood pressure and 21 per cent lower insulin sensitivity than those with older siblings.”

Dr. Cutfield and his associates recruited 26 first-borns and 24 second-borns as part of their research, and used an oral glucose tolerance test in order to assess each subject’s insulin sensitivity. In addition, they report using other assessment methods, including DXA-derived body composition, lipid profiles and 24-hour ambulatory blood pressure in order to gauge the overall fitness levels of each study participant.

Despite the weight and insulin resistance differences, the investigators found no significant difference between first and second-born men in terms of ambulatory blood pressure, lipid profile or carotid intima-media thickness. Even so, the results suggest that first-born adults could face an increased risk of metabolic and cardiovascular diseases.

According to Christopher Allen, senior cardiac nurse at the British Heart Foundation, lower insulin sensitivity increases a person’s risk of developing type 2 diabetes. In addition, he said that it was important to “note where you carry your weight,” as those who carry extra fat in their middle are more likely to be insulin resistant.

“The significance of the latest study, although it is only a snapshot of one age group, is that it may reflect the metabolic effects of the shrinking of the typical New Zealand family since the 1960s,” Johnson added. “The fertility rate shrank from a peak of 4.3 births per woman in 1961, to 3.2 in 1971 – and was 2 in 2012. Smaller families mean a higher proportion of first-born people in a society.”

Mountainous Ecosystems Acted Like A Thermostat For Millions Of Years

University of Oxford

For the first time, scientists have discovered how tree roots in the mountains may play an important role in controlling long-term global temperatures. Researchers from Oxford and Sheffield Universities have found that temperatures affect the thickness of the leaf litter and organic soil layers, as well as the rate at which the tree roots grow. In a warmer world, this means that tree roots are more likely to grow into the mineral layer of the soil, breaking down rock into component parts which will eventually combine with carbon dioxide. This process, called weathering, draws carbon dioxide out of the atmosphere and cools the planet. The researchers say this theory suggests that mountainous ecosystems have acted like the Earth’s thermostat, addressing the risk of ‘catastrophic’ overheating or cooling over millions of years.

In their research paper published online in Geophysical Research Letters, the researchers carried out studies in tropical rain forests in Peru, measuring tree roots across different sites of varying altitude – from the warm Amazonian Lowlands to the cooler mountain ranges of the Andes. They measured the growth of the tree roots to 30 cm beneath the surface, every three months over several years. At each of the sites, they also measured the thickness of the organic layer above the soil. This information was then combined with existing data of monthly temperature, humidity, rainfall, and soil moisture in order to calculate the likely breakdown process of the basalt and granite rocks found in the mountain ranges of Peru.

Using this model, based on field data in Peru, the scientists were able to scale up in order to calculate the likely contribution of mountain forests worldwide to global weathering rates. The researchers then calculated the likely amount of carbon to be pulled out of the atmosphere through weathering when the Earth became very hot. They looked at the volcanic eruptions in India 65 million years ago (known as the Deccan traps). The model also allowed them to calculate the weathering process and carbon feedback after the Earth’s cooling 45 million years ago, when great mountain ranges like the Andes and the Himalayas were first formed.

The paper suggests that mountainous regions may play a particularly important role in drawing carbon out of the atmosphere because they have abundant volcanic rock which is highly reactive to weathering when it disintegrates.

Lead researcher Chris Doughty, from the School of Geography and the Environment at the University of Oxford, said: This is a simple process driven by tree root growth and the decomposition of organic material. Yet it may contribute to Earth’s long-term climate stability. It seems to act like a thermostat, drawing more carbon dioxide out of the atmosphere when it is warm and less when it is cooler.

“A series of climatic events over the last 65 million years ago have resulted in global temperatures rising and falling. However, the weathering process that regulates carbon dioxide in the atmosphere may be buffered by forests that grow in mountainous parts of the world. In the past, this natural process may have prevented the planet from reaching temperatures that are catastrophic for life.”

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Can Eating More Low-Fat Yogurt Lessen Type 2 Diabetes Risk?

[ Watch the Video: Eat More Yogurt To Lower Diabetes Risk ]

Brett Smith for redOrbit.com – Your Universe Online

New research has shown that regular consumption of low-fat yogurt can reduce the risk of developing type 2 diabetes, according to a study published in the journal Diabetologia.

The study researchers found that a higher consumption of low-fat fermented dairy products, which included some low-fat cheeses, cut the risk of type 2 diabetes onset by 28 percent and reduced the relative risk of diabetes by 24 percent overall.

Previous analyses on connections between dairy product usage and diabetes have had inconclusive findings, prompting scientists at the University of Cambridge in the UK to carry out this new investigation using a more detailed evaluation of dairy product intake than was done in previous efforts.

“This research highlights that specific foods may have an important role in the prevention of type 2 diabetes and are relevant for public health messages,” said Dr. Nita Forouhi, from the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge.

The team reached their conclusion using the EPIC-Norfolk study, which included greater than 25,000 men and women living in Norfolk, UK. The study included an in-depth analysis of daily food and drink records from over 750 people who developed new-onset type 2 diabetes over 11 years, along with over 3,500 randomly selected study participants. The analysis allowed the scientists to look at the risk of diabetes in terms of the intake of overall dairy products and also kinds of individual dairy products being eaten.

The intake of overall dairy, overall high-fat dairy or overall low-fat dairy was not connected with new-onset diabetes when confounding factors like healthier lifestyles, education, obesity levels, other consuming habits and overall calorie intake were considered. Overall, milk and cheese intakes were also not connected with diabetes risk. Those with the highest usage of low-fat fermented dairy products were 24 percent less likely to develop type 2 diabetes over the course of the study, compared with those who didn’t eat the dairy products.

When considered separately from the other low-fat fermented dairy products, yogurt, which makes up greater than 85 percent of these products, was connected with a 28 percent decreased risk of getting diabetes. This risk reduction was seen among individuals who ate an average of four-and-a-half standard portions of yogurt per week. The same finding applied to other low-fat fermented dairy products such as low-fat non-fermented cheeses, like low-fat cottage cheese. The researchers also found that consuming yogurt in place of other snacks, like potato chips, also reduced the risk of establishing type 2 diabetes.

The authors noted the limitations of dietary research which depends on participants’ self-reports and not considering changes in diets over time. However, they noted that their study was large with long follow-up, and had a comprehensive assessment of people’s diets that was gathered in real-time as people ate the foods, as opposed to relying on past memory.

The study team concluded that their study supplies robust evidence that intake of low-fat fermented dairy products is linked with a lowered risk of creating future type 2 diabetes.

“At a time when we have a lot of other evidence that consuming high amounts of certain foods, such as added sugars and sugary drinks, is bad for our health, it is very reassuring to have messages about other foods like yoghurt and low-fat fermented dairy products, that could be good for our health,” Forouhi said.

Illuminating The Complexities Of Endometriosis

April Flowers for redOrbit.com – Your Universe Online
Affecting at least 10 percent of women, endometriosis is a disease characterized by endometrial-like tissue found in places other than the lining of the womb, resulting in chronic pelvic pain, infertility and organ dysfunction. Endometriosis is often misdiagnosed, and little is known about how it arises, even though it can cause severe pain and even infertility.
In 2009, the Center for Gynepathology Research was launched at MIT by biological engineer Linda Griffith, with the goal of learning more about the molecular and cellular basis for endometriosis. This would give scientists better drug targets and help doctors decide how to best treat individual patients.
Griffith collaborated with Keith Isaacson, director of the Newton-Wellesley Hospital Center for Minimally Invasive Gynecologic Surgery, and Michael Beste, a postdoc in MIT’s Department of Biological Engineering, to identify pattern of immune system signaling molecules that correlates with certain symptoms of endometriosis. The team also identified the underlying cellular activity that produces this signature, which was described in a recent issue of Science Translational Medicine.
The identification of this signature could help researchers develop a patient stratification system similar to that used for breast cancer patients, which tailors treatments to the specific molecular profile of the tumor.
“Endometriosis patients report symptoms of infertility and pain, and beyond that, it’s just kind of a guessing game. There are few molecular mechanisms known,” Griffith told Anne Trafton of the MIT News Office.
Due to widespread lack of awareness, endometriosis is often undiagnosed or misdiagnosed for many years. The symptoms and severity of the disease can vary, making it difficult to study.
“The delay to a conclusive diagnosis can range anywhere from three to 15 years,” Beste said. “There’s a real need in the field to improve our understanding of both the basic biology and the clinical manifestations of the disease to better treat and improve the quality of life of affected women.”
Endometriosis is often called a “disease of theories” because so little is known about how it works. The theories range from genetics, to environmental toxicants, to a “broken” immune system to reflux menstruation — but so far, no definitive answer has been found for why so many women are afflicted with this disease.
“We know there is a genetic component, we know there is an environmental component, and we know there is an inflammatory component. But it’s very difficult to say for individual patients what particular sequence of events led to particular symptoms,” Beste said.
Because the disease itself is so little understood, the treatments are not reliable as cures. It is often treated with hormones to produce a menopausal state — which is impractical for women wanting to become pregnant. Select medications are currently used in endometriosis treatment, but these merely minimize symptoms and do not actually treat the disease. Laparoscopic Excision surgery has the highest success rate, but is also not a universal cure. Some women may undergo surgery several times over the course of their life, particularly if endometriosis is superficially treated and not excised.
The new study analyzed peritoneal fluid from 77 patients who reported a wide range of symptom severity. Fifty proteins, including inflammatory compounds known as cytokines, were measured for each sample. Cytokines are used by the body to regulate infectious agents, but can also cause inflammation in the absence of any pathogen, as they do during endometriosis.
A distinctive profile of cytokine activity was found by the researchers to be associated with certain symptoms, specifically ovarian and rectovaginal lesions. Thirteen cytokines were included in the pattern, which also negatively correlated with patient infertility.
Many of the inflammatory compounds that are included in the signature have been previously implicated in endometriosis. The researchers identified c-Jun, a protein that drives inflammation, as one of the key regulators of the newly discovered signature. c-Jun has been linked to endometriosis by prior research, and clinical trials are proceeding on a drug to inhibit the protein.
The team also discovered that many of the molecules that make up the signature are secreted by macrophages, which are a type of immune cell that acts as a guardian. Macrophages patrol tissues, digest foreign materials and present them to other immune cells.
The researchers are continuing their research by investigating the triggers for this immune response, which are likely not the same in every patient. The new study will analyze tissue from subsets of endometriosis patients, including those who experience infertility and those with deeply infiltrating lesions affecting the colon and other pelvic organs. Additionally, they hope to conduct a long-term study of patients who will be tracked from the first report of symptoms. Studies such as these could lead to targeted drugs, as well as a better understanding of a highly complex disease.
“This paper isn’t to say we discovered the answer. We’re trying to start a conversation with a broad translational science community about this because it is such a terrible disease,” Griffith said. “We found something really interesting, but it’s only the tip of the iceberg, and if other clinicians are interesting in setting up a similar study with their patients, we’re happy to talk about collaborating with them.”
Heather C. Guidone, Surgical Program Director at the Center for Endometriosis Care, commented on the new research: “Having been with Dr. Griffith and her team at their Center’s launch in 2009, I am always encouraged to see their research progression. It is without question that endometriosis continues to negatively impact the social, physical, emotional and sexual quality of life for 176 million women and adolescents globally; not to mention the profound economic consequences of the disease on society as a whole. There remains an urgent need for continued clarity on pathogenesis, pain mechanisms and potential links to other morbidities; while preliminary, the collaborative conversation started by Dr. Griffith and the MIT team gives us hope that the isolation, lack of public understanding and barriers to quality care faced by so many struggling with this insidious disease may one day – hopefully soon – become things of the past.”

Black Holes Heated The Early Universe Later Than Previously Believed

[ Watch the Video: Black Holes Heated Gas Later Than Believed ]

redOrbit Staff & Wire Reports – Your Universe Online

In what is being described as a landmark discovery about the origins of the universe, Tel Aviv University researchers report in the journal Nature that black holes, formed from the first-ever stars, heated the gas throughout space much later than previously believed.

In addition, study authors Professor Rennan Barkana of TAU’s School of Physics and Astronomy, Dr. Anastasia Fialkov of the École Normale Supérieure in Paris and Dr. Eli Visbal of Harvard University imprinted a clear signature in radio waves that can be searched for by astronomers.

“One of the exciting frontiers in astronomy is the era of the formation of the first stars,” Barkana explained in a statement. “Since the universe was filled with hydrogen atoms at that time, the most promising method for observing the epoch of the first stars is by measuring the emission of hydrogen using radio waves.”

Just like archaeologists here on Earth, astronomers often work to explore the universe during its earliest days, only they are able to see directly into the past thanks to the length of time it takes far-off objects to reach our world. This phenomenon allows scientists to view objects as they were when the light was first emitted, the investigators explained, and can even allow them to observe the first stars as they actually were in the ancient past.

“Thus, the new finding that cosmic heating occurred later than previously thought means that observers do not have to search as far, and it will be easier to see this cosmic milestone,” TAU said. “Cosmic heating may offer a way to directly investigate the earliest black holes, since it was likely driven by star systems called ‘black-hole binaries.’”

Black-hole binaries are pairs of stars in which the larger of the two ended its lifespan with a supernova explosion that left behind a black-hole remnant, the authors said. It then pulls in gas from the surviving companion star, ripping it apart with its strong gravitational forces and emitting high-energy X-rays capable of traveling great distances. This radiation is believed to have re-heated cosmic gases cooled following the original cosmic expansion.

However, Prof. Barkana and his colleagues now report that the heating did not occur very early on, as they had previously believed. On the basis of their research, they discovered that “this standard picture delicately depends on the precise energy with which the X-rays come out.”

“Taking into account up-to-date observations of nearby black-hole binaries changes the expectations for the history of cosmic heating,” he added. “It results in a new prediction of an early time (when the universe was only 400 million years old) at which the sky was uniformly filled with radio waves emitted by the hydrogen gas.”

These discoveries contradict the common view that cosmic heating took place too early to be visible – an assumption upon which modern radio telescope arrays were constructed. Those instruments were designed to detect radio waves given off by hydrogen resulting from later cosmic events. However, the study authors claim that their findings indicate that these telescopes could also be used to locate cosmic heating from the earliest black holes.

Do Birds Communicate With Their Eyes?

University of Cambridge

Researchers in Cambridge and Exeter have discovered that jackdaws use their eyes to communicate with each other – the first time this has been shown in non-primates.

While what humans do with their eyes has been well studied, we know almost nothing about whether birds communicate with members of the same species with their eyes.

The new study, published today in Biology Letters, shows that jackdaw eyes are used as a warning signal to successfully deter competitors from coming near their nest boxes.

Gabrielle Davidson of the University of Cambridge, who led the study, said: “Jackdaw eyes are very unusual. Unlike their close relatives, the rooks and crows – which have very dark eyed – jackdaw eyes are almost white and their striking pale irises are very conspicuous against their dark feathers.”

While most birds have black or dark brown eyes, bright eyes are not unknown in the avian world, and around 10% of passerines (perching birds) have colored irises. The question Davidson wanted to answer was do jackdaws use their bright eyes to communicate with fellow jackdaws?

Just before the spring breeding season arrived last year, Davidson installed one of four different pictures in 100 jackdaw nest boxes on the outskirts of Cambridge. The pictures were either black (the control), a pair of jackdaw eyes, a pair of jackdaw eyes in a jackdaw’s face, or a jackdaw’s face with a pair of black rook eyes. She then filmed the effect the different pictures had on the birds’ behavior.

“Jackdaws are unique among the crow family in that they nest in cavities in trees. These hollows are natural – the birds cannot excavate their own nest cavities as some woodpeckers do – so they have to compete for a limited resource. And because jackdaws nest in close proximity to each other, they fight a lot to gain the best nesting sites,” she explained. Often what initiates these fights are jackdaws approaching nest boxes that are not their own.

After analyzing 40 videos of jackdaws peeking into each other’s nest boxes, she found that compared with the other nest boxes, those that contained the picture of a jackdaw with its bright eyes was much more likely to deter the birds from landing on it, and that the birds spent less time near such a nest box.

Davidson’s study is the first to show the eyes being used as a means of communication between members of the same species outside primates.

“Before now we knew very little about why some birds have brightly coloured eyes. In jackdaws, the pale eyes may function to improve their ability to defend their nest and chicks from competitors. It also raises the question of whether this is unique to jackdaws, or if other cavity nesting birds also use their eyes in a similar way,” she added.

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How Do Honeybees Taste?

Frontiers

New research on the ability of honeybees to taste with claws on their forelegs reveals details on how this information is processed, according to a study published in the open-access journal, Frontiers in Behavioral Neuroscience.

Insects taste through sensilla, hair-like structures on the body that contain receptor nerve cells, each of which is sensitive to a particular substance. In many insects, for example the honeybee, sensilla are found on the mouthparts, antenna and the tarsi – the end part of the legs. Honeybees weigh information from both front tarsi to decide whether to feed, finds the latest study led by Dr. Gabriela de Brito Sanchez, researcher, University of Toulouse, and Dr. Martin Giurfa, Director of the Research Centre on Animal Cognition, University of Toulouse, France.

Hundreds of honeybees were included in the study. Sugary, bitter and salty solutions were applied to the tarsi of the forelegs to test if this stimulated the bees to extend or retract their tongue – reflex actions that indicate whether or not they like the taste and are preparing to drink. Results revealed that honeybee tarsi are highly sensitive to sugar: even dilute sucrose solutions prompted the bees to extend their tongue. Measurements of nerve cell activity showed that the part of the honeybee tarsus most sensitive to sugary tastes is the double claw at its end. Also, the segments of the tarsus before the claws, known as the tarsomeres, were found to be highly sensitive to saline solutions.

“Honeybees rely on their color vision, memory, and sense of smell and taste to find nectar and pollen in the ever-changing environment around the colony,” says Dr. Giurfa. “The high sensitivity to salts of the tarsomeres and to sugar of the tarsal claws is impressive given that each tarsus has fewer sensilla than the other sense organs. The claw’s sense of taste allows workers to detect nectar immediately when they land on flowers. Also, bees hovering over water ponds can promptly detect the presence of salts in water through the tarsomeres of their hanging legs.”

But what if honeybees receive contradictory information, for example, about tasty sucrose from the right foreleg, but about water or distasteful caffeine from the left? The central nervous system of honeybees weighs this information from both sides, but unequally: input from the side that is first to taste something tasty or distasteful counts for more. For example, if a bee first tasted sucrose on one side, she would typically extend her tongue and subsequently ignore less attractive tastes on the other. But if the order was reversed, she was around 50% less likely than normally to extend her tongue for sucrose.

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Educational Toolkit Did Not Improve Quality Of Care Or Outcomes For Patients With Diabetes

An educational toolkit designed to improve care of patients with diabetes was not effective, Baiju R Shah and colleagues (University of Toronto) found in a cluster randomized trial conducted in 2009-2011. During 10 months of follow-up, patients of Canadian family physicians who had been cluster-randomized to receive the toolkit did not receive improved care and their outcomes did not differ compared with patients of physicians who did not receive the toolkit. All 933,789 people aged ≥40 years with diagnosed diabetes in Ontario, Canada, were studied using population-level administrative databases and evaluated for the primary outcome in the administrative data study, death or non-fatal myocardial infarction. This composite outcome occurred in 11,736 (2.5%) patients in the intervention group and 11,536 (2.5%) in the control group (p = 0.77). Additional clinical outcome data was collected from a random sample of 1,592 high risk patients. The primary outcome in this clinical data study was use of a statin; this occurred in 700 (88.1%) patients in the intervention group and 725 (90.1%) in the control group (p = 0.26). Other secondary outcomes, including other clinical events, were also not improved by the intervention. In a few cases the educational toolkit was actually associated with slightly worse process-of-care outcomes. A limitation was that a very high proportion of the high risk patients in the clinical study group were already prescribed statins. The authors conclude, “The results of this study highlight the need for a rigorous and scientifically based approach to the development, dissemination, and evaluation of quality improvement interventions.”

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Self-Healing Polymers From Off-The-Shelf Materials

University of Illinois at Urbana-Champaign

Look out, super glue and paint thinner. Thanks to new dynamic materials developed at the University of Illinois, removable paint and self-healing plastics soon could be household products.

U. of I. materials science and engineering professor Jianjun Cheng, graduate student Hanze Ying and postdoctoral researcher Yanfeng Zhang published their work in the journal Nature Communications.

“The key advantage of using this material is that it’s catalyst-free and low-temperature, and can be healed multiple times,” Cheng said. “These are very nice materials for internal cracks. This can heal the crack before it causes major problems by propagating.”

Other self-healing material systems have focused on solid, strong materials. However, the new study uses softer elastic materials made of polyurea, one of the most widely used classes of polymers in consumer goods such as paints, coatings, elastics and plastics.

After the polymer is cut or torn, the researchers press the two pieces back together and let the sample sit for about a day to heal – no extra chemicals or catalysts required. The materials can heal at room temperature, but the process can be sped up by curing at slightly higher temperatures (37 degrees Celsius, or about body temperature). The polymer bonds back together on the molecular level nearly as strongly as before it was cut. In fact, tests found that some healed samples, stretched to their limits, tore in a new place rather than the healed spot, evidence that the samples had healed completely.

See a video demonstrating the preparation and self-healing properties.

The researchers use commercially available ingredients to create their polymer. By slightly tweaking the structure of the molecules that join up to make the polymer, they can make the bonds between the molecules longer so that they can more easily pull apart and stick back together – the key for healing. This molecular-level re-bonding is called dynamic chemistry.

Dynamic chemistry has been explored in some other polymers, but those materials tend to be for specialized applications or laboratory settings, rather than the conventional polymers used commercially. By focusing on consumer materials and using readily available ingredients, the researchers hope that manufacturers could easily integrate dynamic materials.

“We just buy commercial materials and mix them together, no fancy controls or special apparatus,” said Cheng. “It’s a very simple, low-cost, inexpensive process. Anybody can do this on any scale.”

Now that they’ve established the chemistry required, the researchers are exploring how dynamic polyurea could bolster different applications. For example, they could fine-tune the mixture so that a polyurethane coating or paint could be removable.

“In some areas, when it’s not necessary for the coating to be permanent and you want it to be removable, this chemistry may be applied to existing coating materials to make it reversible,” Cheng said. “In general, polyurea and polyurethane are widely used. This chemistry could modify existing materials to make them more dynamic, healable.”

The National Science Foundation and the National Institutes of Health supported this research. Cheng also is affiliated with the departments of chemistry and of bioengineering, the Beckman Institute for Advanced Science and Technology, the Institute for Genomic Biology, the Frederick Seitz Materials Research Laboratory and the Micro and Nano Technology Laboratory at the U. of I.

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Brain Edits, Splices Past Memories With Current Events

[ Watch the Video: Brains Edits Past Memories ]

Brett Smith for redOrbit.com – Your Universe Online

While we may like to think of our brains as a video camera that records events exactly as they happen, a new study from scientists at Northwestern University has found that the brain acts more like an editing studio, cutting and splicing past events based on present circumstances.

“When you think back to when you met your current partner, you may recall this feeling of love and euphoria,” said Donna Jo Bridge, a postdoctoral fellow in medical social sciences at Northwestern University and lead author of the new study, set to be published this week in the Journal of Neuroscience.

“But you may be projecting your current feelings back to the original encounter with this person,” Bridge added.

The study team found that editing happens in the hippocampus, which reframes and edits events to create a narrative that fits an observer’s current world view.

For the study, 17 men and women studied nearly 170 object locations on a computer screen with diverse backdrops such as an underwater scene or an aerial view of farmland. Next, scientists asked volunteers to try to place the object in the original location but on a new backdrop. Study researchers found that their volunteers would always place the objects in a wrong location on the screen.

For the last part of the study, volunteers were shown the item in three locations on the original backdrop and asked to select the correct location. Their options were: the location they originally saw the item, the location they placed it in part two of the experiment or a completely new location.

“People always chose the location they picked in part two,” Bridge said. “This shows their original memory of the location has changed to reflect the location they recalled on the new background screen. Their memory has updated the information by inserting the new information into the old memory.”

Study volunteers performed the test in an MRI scanner so researchers could observe their brain activity. The study team also tracked participants’ eye motions, which at times were more revealing about their memories – and if there had been conflict in their selections – than the location they wound up choosing.

Study author Joel Voss, an assistant professor of medical social sciences and of neurology at Northwestern, said the idea of a perfect memory is a myth.

“Everyone likes to think of memory as this thing that lets us vividly remember our childhoods or what we did last week,” Voss said. “But memory is designed to help us make good decisions in the moment and, therefore, memory has to stay up-to-date. The information that is relevant right now can overwrite what was there to begin with.”

Bridge noted the study could have consequences for analyzing testimony in a court of law.

“Our memory is built to change, not regurgitate facts, so we are not very reliable witnesses,” she said.

Bridge did note that the study was conducted in a controlled experimental setting.

“Although this occurred in a laboratory setting, it’s reasonable to think the memory behaves like this in the real world,” Bridge said.

Americans Excited Over DNA Breakthroughs, But Many Worry About The Implications: Poll

[ Watch the Video: What Do People Really Think About DNA Research? ]
April Flowers for redOrbit.com – Your Universe Online
A new poll from the Huffington Post and YouGov finds that although most Americans are excited by the possibility of the scientific breakthroughs made possible by DNA research, many of them worry that research could go too far — and the scientists could begin “playing God.”
The possibility that DNA research could create major scientific and medical breakthroughs is exciting to most Americans (71 percent). However, 44 percent also worry that DNA research involves dangers that are not well understood or anticipated. Another 33 percent expressed both excitement and trepidation.
The poll was conducted January 16-17, 2014 among 1,000 American adults. The sample was selected from YouGov’s opt-in online panel to match the demographics and other characteristics of the adult population of the nation. Factors such as age, race, gender, education, employment, income, marital status, number of children, voter registration, time and location of Internet access, interest in politics, religion and church attendance were all taken into consideration.
HuffPo reports that the results show the public is more optimistic about the possibilities than pessimistic about potential negative effects. The findings also reveal that Americans believe genetic research should have limits.
For example, when asked about the idea of cloning extinct species — like in the Jurassic Park franchise — most said they were against the idea of resurrecting woolly mammoths and other long extinct species by a 55 to 27 percent margin.
Even more disturbing to American respondents is the idea of using genetic research to create “designer babies,” with seventy-two percent disapproving of efforts to create children with unusually high intelligence or other advantageous traits. Of all the respondents, only 16 percent approved of designer babies.
The poll also found that most were at least somewhat worried about the possibility of scientists “playing God” by trying to tweak phenomena they think should remain outside the realm of science — with 35 percent being very worried and another 37 percent being somewhat worried. A combined 19 percent said they were not very worried or not at all worried.
This poll is not the first time such concerns have been raised. In 2008, a team of legal, scientific and ethics experts were calling for research guidelines to be established in the search for the human genome. The team, led by Timothy Caulfield from the Health Law Institute at the University of Alberta in Canada, put forward eight key recommendations for developing ethical oversight.
“Yes, these are early days in the field of human-genome research, but research ethics guidance is needed immediately,” said Caulfield. “With how fast this research is growing, it is necessary that we develop carefully considered consensus guidelines to ensure ethical research practices are defined for all.”
The key recommendations include such things as the right for participants to withdraw consent (which includes the destruction of tissue samples and written information); the issues associated with participants’ family members and relevant groups; and the means of obtaining clear consent from participants for possible future use of their genes.
In 2013, the Catholic Church weighed in on the issue as well. At that time, the chairman of the Committee on Pro-Life Activities of the U.S. Conference of Catholic Bishops (USCCB), Cardinal Sean O’Malley, OFM Cap., of Boston, said that human cloning for any reason is inconsistent with moral responsibility. O’Malley was responding specifically to the nose that researchers in Oregon had succeeded in producing cloned human embryos to obtain embryonic stem cells.
“Creating new human lives in the laboratory solely to destroy them is an abuse denounced even by many who do not share the Catholic Church’s convictions on human life,” said Cardinal O’Malley. “Whether used for one purpose or the other, human cloning treats human beings as products, manufactured to order to suit other people’s wishes.” He added, “A technical advance in human cloning is not progress for humanity but its opposite.”
The HuffPo/YouGov poll seems to reflect some of this discomfort in the general public, as well as showing excitement at the possible advances to come.

Teens Who Consume Energy Drinks Are At Higher Risk Of Substance Abuse

Lee Rannals for redOrbit.com – Your Universe Online

Teens who constantly crack open a Red Bull or Monster energy drink could be at a higher risk of using alcohol and drugs, according to a new study published in the Journal of Addiction Medicine.

The energy drink industry has grown immensely over the past decade, and studies show that nearly one-third of US adolescents consume the high-caffeinated drinks. However, the latest research says that these teens also show higher rates of alcohol, cigarette or drug use.

Researchers analyzed data from nearly 22,000 US secondary students who participated in a University of Michigan study entitled “Monitoring the Future.” The team said the same characteristics that attract young people to consume energy drinks could make them more susceptible to abusing other substances as well.

Energy drinks in the study were classified as those marketed as aids to help increase energy, concentration or alertness.

The study found that 30 percent of the teens reported using energy drinks or shots, while more than 40 percent said they regularly drank soft drinks. The team discovered that boys were more likely to use energy drinks than girls, and teens without two parents at home were also more prone to drink the caffeinated beverages.

According to the study, students who used energy drinks were more likely to report recent use of alcohol, cigarettes and illicit drugs. Energy drinks were linked to certain behavior patterns in young adults as well, such as looking for a different sensation or risk. Drinking soft drinks regularly was linked to a higher use of substance abuse, but it was not as prevalent of a finding as energy drinks.

“The current study indicates that adolescent consumption of energy drinks/shots is widespread and that energy drink users also report heightened risk for substance use,” the researchers from the University of Michigan wrote in the journal.

The study is one of the first to look at the link between energy drink consumption among young adults and substance abuse. The researchers said they believe the link in young adults could be relevant for adolescents as well.

“Education for parents and prevention efforts among adolescents should include education on the masking effects of caffeine in energy drinks on alcohol- and other substance-related impairments, and recognition that some groups (such as high sensation–seeking youth) may be particularly likely to consume energy drinks and to be substance users,” the researchers wrote in the journal.

The team says that energy drinks are not a good dietary choice for teens due to their high caffeine and sugar content. They said that these beverages have “no place in the diet of children and adolescents.”

California Researchers To Begin Testing Kelp For Fukushima Radioactivity

Brett Smith for redOrbit.com – Your Universe Online

With radiation-tainted waters from the Fukushima nuclear disaster expected to wash up on American shores this year, California scientists are taking steps to monitor West Coast waters for radioactivity.

According to a U-T San Diego report, researchers from San Diego State University will begin testing kelp beds off the coast of California for radiation levels. The San Diego scientists said hazardous radioisotopes cesium-134 and cesium-137 from Japan’s Fukushima Daiichi power station could make their way to our shores very soon.

“We don’t know if we’re going to find a signal of the radiation,” project scientist Matt Edwards told U-T San Diego. “And I personally don’t believe it’ll represent a health threat if there is one. But it’s worth asking whether there’s a reason to be concerned about a disaster that occurred on the other side of the planet some time ago.”

The testing is being executed by the Kelp Project, a research program launched by Steve Manley, a California State University Long Beach biologist who has been investigating the ecological effect of the magnitude-9.0 earthquake that hit Japan on March 11, 2011. The earthquake produced a tsunami that hit the Fukushima plant, producing a massive discharge of radioactive material into the ocean.

Less than a month following the catastrophe, Manley discovered small amounts of the radioactive isotope iodine-131 in kelp near Los Angeles. The isotope traveled across the ocean by air – then got rinsed into California’s coastal seas by a rainstorm. Manley published a research paper on his discoveries that stirred public concern, even though he stated that the material didn’t seem to pose a health threat.

“I got emails and calls from people who wanted to know if it was safe to visit the coast and to eat the fish,” Manley says. “I still get emails like that.”

In trying to allay people’s anxieties by more clearly and broadly gauging the radiation in coastal waters, Manley contacted marine scientists along the California coast to question if they would collect kelp samples that would be tested for a couple of kinds of cesium. Manley quickly saw dozens of offers for help, including one from Edwards.

The kelp researchers are expected to plot a course for the Point Loma kelp forest, the largest virtually contiguous area of giant kelp in the northern hemisphere. They also may gather kelp off the coast of northern San Diego County. Samples will be extracted from a minimum of 30 spots off California, and a handful in the Pacific Northwest, Alaska and Baja California. Further north, researchers will collect another related species, known as bull kelp.

The kelp will be dried then grounded into a powder, to facilitate the radioactivity analysis. These tests will be carried out quarterly, for around a year.

“Kelp is the perfect ‘sentinel’ organism for a project like this because it absorbs and concentrates things like radioactive material,” said Manley, a seaweed biologist. “Right now, the radioactivity from Fukushima has not reached here. If it does, we’ll be able to measure it, even though it will be really diluted.”

Scientists Call For Most Women To Have Mammography Screening Every Two Years

Elizabeth Fernandez – University of California – San Francisco
Study led by UCSF breast cancer expert recommends screening guidelines developed by US Preventive Services Task Force
Adoption of new guidelines recommending screening mammography every two years for women ages 50 to 74 would result in breast cancer screening that is equally effective, while saving the United States $4.3 billion a year in health care costs, according to a study led by UC San Francisco.
The study compares three possible mammography screening strategies with a model of current US screening practices.
The article appears on February 4, 2014 in Annals of Internal Medicine.
The authors call for the adoption of guidelines developed in 2009 by the U.S. Preventive Services Task Force (USPSTF). Under those guidelines, in addition to biennial screening for women age 50 to 74, women age 40 to 49 would be screened according to other risk factors, and women 75 and older would be screened depending on the presence or absence of other diseases.
The study was led by Laura J. Esserman, MD, MBA, professor of surgery and radiology at UCSF and an internationally known leader in the field of breast cancer.
“The USPSTF guidelines are based on the best scientific evidence to date,” said Esserman, director of the Carol Franc Buck Breast Care Center at the UCSF Helen Diller Family Comprehensive Cancer Care Center. “What we need now is a better way to assess breast cancer risk and implement a more risk-based approach to screening. We have demonstrated that the resources for doing this are already in the system. We should redirect them to learning, enabling change, and improving outcomes.”
According to the authors’ estimate, approximately 70 percent of women in the US were screened for breast cancer in 2010, at a cost of $7.8 billion. Some women are screened annually, some biennially, and some are screened on an irregular basis.
The scientists compared this current picture of breast cancer screening with three simulated models: annual screening of 85 percent of women age 40 to 84, in accordance with recommendations from the American Cancer Society and many other policymaking organizations, at an annual estimated cost of $10.1 billion; biennial screening of 85 percent of women age 50 to 70, in line with guidelines used in many European countries, at an annual estimated cost of $2.6 billion; and screening in accordance with USPSTF recommendations, which the authors estimate would cost $3.5 billion per year at a screening rate of 85 percent.
“Over the last decade, in study after study, it has become very clear that – apart from limited, specific high risk groups – biennial screening is as effective as annual screening mammography,” said Esserman. “At the same time, annual screening is associated with a greater likelihood of false positive results, which have an adverse impact on women’s well-being and quality of life. From the viewpoint of women’s health, the USPSTF screening recommendations make sense.
“We can go one step further and learn who is at risk for what kind of breast cancer, and over time, further tailor screening by adjusting the age to start and frequency as well as include recommendations for prevention,” Esserman said.
Lead author Cristina O’Donoghue, MD, currently at the University of Illinois at Chicago but with UCSF at the time of the study, noted that the billions of dollars saved from avoiding less-effective mammography screening could be used to improve women’s health.
“We could increase women’s participation in screening, improve routine assessment of breast cancer risk and referral services for women at high risk, offer better genetic counseling for women with a family history of breast cancer and work on improving the quality of screening, with an emphasis on higher-quality mammography read by specialized mammographers,” said O’Donoghue. “These would be only some of the potential benefits of using our health care resources more intelligently.”

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WHO Report Warns Of Impending Global Cancer Disaster

[ Watch the Video: World Cancer Day 2014 ]

Lawrence LeBlond for redOrbit.com – Your Universe Online

Coinciding with World Cancer Day, the World Health Organization’s (WHO) International Agency for Research on Cancer (IACR) released the World Cancer Report 2014, which highlights the need for health professionals around the world to strengthen prevention efforts on a disease that is quickly becoming a global health disaster.

The report maintains that the “global battle against cancer won’t be won with treatment alone [and] effective prevention measures [are] urgently needed to prevent cancer crisis.”

The World Cancer Report 2014 is a collaboration of more than 250 leading scientists from more than 40 countries, describing multiple aspects of cancer research and control. Based on the latest statistics on trends in cancer incidence and mortality across the world, the new report reveals how the cancer burden is growing at an alarming rate and emphasizes the need for urgent implementation of prevention protocols to curb the deadly disease.

“Despite exciting advances, this Report shows that we cannot treat our way out of the cancer problem,” warned Dr Christopher Wild, Director of IARC and co-editor of the World Cancer Report 2014. “More commitment to prevention and early detection is desperately needed in order to complement improved treatments and address the alarming rise in cancer burden globally.”

The report estimates that cancer cases worldwide will rise from 14 million new cases per year now to more than 22 million new cases per year within two decades, a 57 percent increase. Over the same twenty-year period, cancer deaths are expected to rise similarly, from 8.2 million to 13 million annually.

In 2012, the most common cancers diagnosed were lung (1.8 million cases), breast (1.7 million cases) and large bowel (1.4 million cases). The most common causes of cancer death were lung (1.6 million), liver (0.8 million) and stomach (0.7 million).

While cancer is a burden the world over, no place is perhaps harder hit than underdeveloped nations. The report says that more than 60 percent of all cancer cases occur in countries in Africa, Asia and Central and South America – typically where early detection and treatment programs do not exist. These countries also face the burden of accounting for 70 percent of all cancer deaths around the world.

To reverse these trends, better access to effective and affordable cancer treatment programs in developing countries are needed, especially for childhood cancers. Better diagnostic and treatment programs would go a long way in reducing the mortality rates in such countries, even in settings where healthcare services are less well-developed.

However, even the richest countries are experiencing hardships in trying to win the war on cancer, due to the spiraling costs associated with cancer research, prevention, diagnosis and treatment programs and it will only get worse as the number of cases rise. This will make it even more difficult for cancer help to reach developing nations, putting an even greater strain on the global healthcare system.

“In 2010, the total annual economic cost of cancer was estimated to reach approximately US$ 1.16 trillion. Yet about half of all cancers could be avoided if current knowledge was adequately implemented,” reads a statement on the report.

“The rise of cancer worldwide is a major obstacle to human development and well-being. These new figures and projections send a strong signal that immediate action is needed to confront this human disaster, which touches every community worldwide, without exception,” stressed Dr Wild.

While many countries continue to struggle with the double burden of high infection-related cancers – i.e. cervix, liver, stomach – and the rising incidence of cancers – i.e. lung, breast, large bowel – that are associated with industrialized lifestyles, the report authors maintain that implementation of effective vaccine programs can reduce some cancers.

Vaccines given for protection against hepatitis B and human papillomavirus have shown the ability to significantly reduce cancer risks associated with liver and cervix, respectively.

As well, a number of preventable cancer measures can be taken to significantly reduce the risk of disease. These include smoking cessation, alcohol avoidance, obesity and inactivity avoidance, reducing radiation exposure (both from the sun and medical scans), and avoiding air pollution and environmental factors.

In regards to smoking and other forms of tobacco use, cessation campaigns have gone a long way to reduce the exposure and risk behaviors associated with tobacco use. Some of these cancer control measures in high-income countries have worked well, but adequate legislation plays a much bigger role in reducing overall exposure and risk behaviors, the authors stressed.

The WHO’s Framework Convention on Tobacco Control (FCTC) has been one legislative measure that has been critical in reducing tobacco consumption through taxes, advertising restrictions and other regulations to control and discourage the use of tobacco.

The report also maintains that similar approaches would do well for other risky behaviors, such as those associated with alcohol and sugar-sweetened beverage consumption.

“Adequate legislation can encourage healthier behaviour, as well as having its recognized role in protecting people from workplace hazards and environmental pollutants,” report coauthor Dr Bernard Stewart, of the University of New South Wales in Australia, said in a statement. “In low- and middle-income countries, it is critical that governments commit to enforcing regulatory measures to protect their populations and implement cancer prevention plans.”

Reasons For Age-Related Cancer Incidence Increase Identified

redOrbit Staff & Wire Reports – Your Universe Online

Age-related changes in a biochemical process known as DNA methylation could be responsible for the increased risk of cancer in older men and women, according to research appearing in the latest edition of the journal Carcinogenesis.

While medical experts have long known that the aging process is a leading risk factor for the development of several different types of cancer, the exact reasons for that phenomenon have remained unclear. However, many experts have long suspected that DNA methylation might be involved.

As the researchers explained in a statement Monday, DNA methylation is a process during which chemical tags known as methyl groups bind themselves onto genetic material. Methyl groups activate or silence genes by influencing the interactions between DNA and the protein-making mechanisms of cells.

“You can think of methylation as dust settling on an unused switch, which then prevents the cell from turning on certain genes,” study author Dr. Jack Taylor of the National Institute of Environmental Health Sciences (NIEHS) said in a statement. “If a cell can no longer turn on critical developmental programs, it might be easier for it to become a cancer cell.”

As part of their research, Dr. Taylor and his NIEHS colleague Dr. Zongli Xu conducted a genome-wide analysis in search of age-related DNA methylation sites that changed with age, then examined their relationships to cancer and other underlying epigenetic marks. They found that one subset of those sites that become increasingly methylated with age are also disproportionately methylated in multiple types of human cancers.

Using blood samples obtained from more than 1,000 35- to 76-year-old women participating in the Sister Study (a national research initiative to detect the environmental and genetic causes of breast cancer and similar diseases), they focused their efforts on a microarray of 27,000 specific methylation sites.

Dr. Taylor and Dr. Xu found age-related increases in DNA methylation in nearly one-third of those sites, the NIEHS explained in a statement. Next, they looked at three additional data sets from similar research using the same microarray, and located 749 methylation sites that behaved consistently across all four data sets.

“Based on The Cancer Genome Atlas data, we show that these age-related changes are largely concordant in a broad variety of normal tissues and that a significantly higher… that expected proportion” of increasingly methylated age-related sites in several different types of tumors, the authors wrote.

Genes containing those areas were found to be “highly enriched for developmental and signaling pathways,” they added. “Our findings suggest that as cells acquire methylation at age-related sites, they have a lower threshold for malignant transformation that may explain in part the increase in cancer incidence with age.”

FDA Clears The Path For Colon Camera Pill

Brett Smith for redOrbit.com – Your Universe Online

Uncomfortable, but a medically important procedure – many colonoscopies cannot be completed due to physiological reasons or a patient’s history of complexities and procedures in their abdomen.

A camera-in-a-pill device from Given Imaging that recently received federal approval could change how colonoscopies are performed and possibly lower the rate of incomplete colonoscopies.

“PillCam COLON will improve patient care by offering a new and effective colon imaging option for patients who have experienced an incomplete colonoscopy,” Dr. Douglas Rex, a professor of medicine at Indiana University School of Medicine, said in a statement from the company. “Among the limited alternatives available after incomplete colonoscopy, PillCam COLON gives us a minimally invasive, radiation-free option that provides endoscopic images of the same basic type that have made colonoscopy so useful.”

Incomplete colonoscopies occur in about 750,000 patients in the United States each year. Patients with incomplete colonoscopies often receive more costs along with the trouble and danger of other procedures to accomplish the colorectal examination. The occurrence of incomplete colonoscopies is greater in women as a consequence of increase in past pelvic operations and the varying anatomy of women that includes significantly acute angles in thin women. Patients with a redundant or particularly lengthy colon, background of abdominal surgery or progressed diverticular disease may also be at a higher risk for enduring an incomplete colonoscopy.

“We have made tremendous strides in increasing the number of people who are getting screened for colon cancer, starting at age 50 for the average risk individual,” said Eric Hargis, CEO, Colon Cancer Alliance, in the company statement. “Colonoscopy is the most comprehensive option, but for up to 10 percent of individuals, achieving a complete colonoscopy may not be possible.”

“For those individuals, PillCam COLON capsule endoscopy could be an effective option to allow their gastroenterologist to complete a colon examination,” Hargis said.

In seeking approval of the camera pill, Given Imaging conducted an 884-patient, 16-site clinical trial investigating the consistency and safety of PillCam COLON compared to optical colonoscopy in finding benign growths 6 millimeters or larger. The outcome of this clinical trial indicated that the sensitivity for PillCam COLON was 88 percent and specificity was 82 percent in finding adenomas at least 6 millimeters in size.

The FDA established its clearance decision on an investigation of this clinical trial data that used a more limited methodology for matching polyps, Given Imaging said. In this analysis, which was conducted on hyperplastic polyps and benign growths, the positive percent match between PillCam COLON and optical colonoscopy was 69 percent and negative percent agreement was 81 percent for polyps not less than 6 millimeters in size.

“The clearance of PillCam COLON by the FDA represents a pivotal moment in the evolution of Given Imaging as a GI medical device leader,” said Homi Shamir, President and CEO, Given Imaging. “We look forward to working closely with the US gastroenterology community to bring this clinically-proven, diagnostic tool to patients who need to have a thorough colorectal exam following an incomplete colonoscopy.”

“While we believe that PillCam COLON will ultimately play an important role in both the global colorectal cancer diagnostic and screening market, this initial indication is an important first step,” Shamir added. “To this end, we are making good progress in advancing additional clinical studies that should support the expanded indications.”

New Microscopy Method Could Spot Dozens Of Distinct Types Of Biomolecules At The Same Time

Wyss Institute for Biologically Inspired Engineering at Harvard

A new microscopy method could enable scientists to generate snapshots of dozens of different biomolecules at once in a single human cell, a team from the Wyss Institute of Biologically Inspired Engineering at Harvard University reported Sunday in Nature Methods.

Such images could shed light on complex cellular pathways and potentially lead to new ways to diagnose disease, track its prognosis, or monitor the effectiveness of therapies at a cellular level.

Cells often employ dozens or even hundreds of different proteins and RNA molecules to get a complex job done. As a result, cellular job sites can resemble a busy construction site, with many different types of these tiny cellular workers coming and going. Today’s methods typically only spot at most three or four types of these tiny workers simultaneously. But to truly understand complex cellular functions, it’s important to be able to visualize most or all of those workers at once, said Peng Yin, Ph.D., a Core Faculty member at the Wyss Institute and Assistant Professor of Systems Biology at Harvard Medical School.

“If you can see only a few things at a time, you are missing the big picture,” Yin said.

Yin’s team sought a way to take aerial views of job sites that could spot up to dozens of types of biomolecules that make up large cellular work crews.

To capture ultrasharp images of biomolecules, they had to overcome laws of physics that stymied microscopists for most of the last century. When two objects are closer than about 200 nanometers apart — about one five-hundredth the width of a human hair — they cannot be distinguished using a traditional light microscope: the viewer sees one blurry blob where in reality there are two objects.

Since the mid-1990s, scientists have developed several ways to overcome this problem using combinations of specialized optics, special fluorescent proteins or dyes that tag cellular components.

Ralf Jungmann, Ph.D., now a postdoctoral fellow working with Yin at the Wyss Institute and Harvard Medical School, helped develop one of those super-resolution methods, called DNA-PAINT, as a graduate student. DNA-PAINT can create ultrasharp snapshots of up to three cellular workers at once by labeling them with different colored dyes.

To visualize cellular job sites with crews of dozens of cellular workers, Yin’s team, including Jungmann, Maier Avendano, M.S., a graduate student at Harvard Medical School, and Johannes Woehrstein, a postgraduate research fellow at the Wyss Institute, modified DNA-PAINT to create a new method called Exchange-PAINT.

Exchange-PAINT relies on the fact that DNA strands with the correct sequence of letters, or nucleotides, bind specifically to partner strands with complementary sequences. The researchers label a biomolecule they want to visualize with a short DNA tag, then add to the solution a partner strand carrying a fluorescent dye that lights up only when the two strands pair up. When that partner strand binds the tagged biomolecule, it lights up, then lets go, causing the biomolecule to “blink” at a precise rate the researchers can control. The researchers use this blinking to obtain ultrasharp images.

They then repeat the process to visualize a second target, a third, and so on. Then they overlay the resulting images to create a composite image in which each biomolecule – each cellular worker — is assigned a different color. This allows them to create false-color images that simultaneously show many types of biomolecules — far more than they could simultaneously visualize by labeling them with different colored dyes. And these false-color images allow them to spot enough cellular workers at once to capture the entire scene.

To test Exchange-PAINT, the researchers created 10 unique pieces of folded DNA, or DNA origami, that resembled the numerals 0 through 9. These numerals could be resolved with less than 10 nanometers resolution, or one-twentieth of the diffraction limit.

The team was able to use Exchange-PAINT to capture clear images of the 10 different types of miniscule DNA origami structures in one image. They also used the method to capture detailed, ultrasharp images of fixed human cells, with each color tagging an important cellular component – microtubules, mitochondria, Golgi apparatus, or peroxisomes.

Yin expects the method, with further development, to be able to visualize dozens of cellular components at once.

“Peng’s exciting new imaging work gives biologists an important new tool to understand how multiple cellular components work together in complex pathways,” said Wyss Institute Founding Director Don Ingber, M.D., Ph.D. “I expect insights from those experiments to lead to new ways to diagnose and monitor disease.” Ingber is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children’s Hospital and Professor of Bioengineering at Harvard School of Engineering & Applied Sciences.

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Magnesium & fibromyalgia

Magnesium & fibromyalgia

Fibromyalgia is a chronic pain condition that affects the muscles and joints in the body.  Those with fibromyalgia are consistently looking for pain relief alternatives that are safe and natural. There are some natural solutions that claim to alleviate and make better the pains of fibromyalgia. Each treatment and combination works well for different people, so it can take quite a bit of time to find a combination of natural treatments that can improve conditions and quality of life.

There is no cure for fibromyalgia, but traditional treatments include drug treatments and medications, as well as alternative therapy and physical therapy. Pharmaceutical drugs often prescribed and recommended include corticosteroids and NSAIDS, as well as acetaminophen and other medications.  Some people have success with these methods of treatment, and others do not do so well, it really depends on the person.

Many people use physical therapies such as massage to alleviate their pains.  Regular massage can help loosen tight muscles and can help with stiffness and other pain.  Some people choose to go to a massage therapist in order to get total relaxation out of the experience, which can also be great for stress management.

Other people choose to do massage at home, as it is free and can be done on a daily basis whenever necessary.  The recommended way to do at home massage involves using a tennis ball to massage and roll over the painful muscles, using gentle pressure.

A warm bath or shower in the morning can also help to ease stiffness, and is recommended for those who are very stiff and sore in the morning.

There are various other natural remedies for the pain of fibromyalgia including trigger point therapy. Other treatment plans for the occurrence of irritable bowel syndrome include removing toxins from the body and using natural supplements to improve health.

Magnesium is a supplement that has gained popularity for those suffering from fibromyalgia.  Magnesium supports over 300 functions in the body and is a necessary element. Studies have found that people with lower levels of magnesium have greater symptoms of fibromyalgia.

Magnesium is often measures in the serum (clear liquid portion of the blood) and in the red blood cells.  Lower levels of magnesium led to higher amounts of fatigue, headache, numbness, irritability, depression and anxiety, as well as reduced physical functioning.

Those with low magnesium levels in the serum also had trouble sleeping and had some stomach issues. If the magnesium levels in the red blood cells were low, people were more likely to experience greater pain and tenderness.

In a study conducted, magnesium reduced muscle cramps and increased physical functioning.  This study went on to test a combination treatment when magnesium was administered with amitriptyline, which is an antidepressant. When these two (magnesium and amitriptyline were taken together, there was significant reduction in pain, fatigue, sleep disorder, irritability, and anxiety.

Supplementing with magnesium led to reduced muscle tenderness and also taking magnesium at bedtime helped improve sleep when done with the anti-depressant.

One treatment is the Four-R plan for gastrointestinal health.  The first step is to remove harmful toxins.  This involves eliminating different foods that are causing problems and inflammation in the digestive tract. This can range in items, and could include gluten, dairy, eggs, corn, potatoes and other.

Instead food is supplemented with antifungal materials including fish, vegetables, rice, coconut and olive oil, and others.  The second R is to replace digestive functioning by taking an enzyme to aid digestion.  Next, good bacteria are introduced into the body with probiotics.  Finally, the gut lining should be repaired by taking supplements including l-glutamine, fish oils and other.

This treatment is to treat the digestive and intestinal problems that are often associated with fibromyalgia.  Clearing the digestive tract can also clear the mind, resulting in a clearer thought process, concentration and memory.

Patients who are looking for a natural treatment for fibromyalgia can consider many different varieties of treatment.  Massage and physical therapy are hands-on approaches that can decrease pain and stiffness and can relieve some of the tender points on the body.

Eating healthy foods can be helpful in easing the digestive tract and improving the bowels.  It is also important to maintain and implement an exercise plan that is easy on the muscles and joints.  Exercise is not only great for the body but it also increases serotonin levels, which can combat depression and anxiety.

Adding a natural supplement such as magnesium, and others, can also be helpful in managing pain and improving symptoms.

Unmanned Military Convoy Completes Successful Demonstrations

[ Watch the Video: Autonomous Convoys Tested By The US Army ]

redOrbit Staff & Wire Reports – Your Universe Online
As part of an initiative to develop military trucks capable of traversing dangerous territory without risking the lives of soldiers, the US Army has successfully conducted a series of demonstrations involving fully autonomous convoys.
The tests were conducted earlier this month at Fort Hood in Texas, and according to Wired’s Allen McDuffee, the Army’s Tank-Automotive Research, Development and Engineering Center (TARDEC) and Lockheed Martin successfully showed that convoys comprised of various types of driverless vehicles of various models were capable of operating in urban environments.
During the tests, the vehicles were tasked with navigating a series of hazards and obstacles, including road intersections, oncoming traffic, stalled vehicles, pedestrians and traffic circles. The demonstration completed the AMAS program’s Capabilities Advancement Demonstration (CAD), Lockheed Martin said in a statement.
“The AMAS CAD hardware and software performed exactly as designed, and dealt successfully with all of the real-world obstacles that a real-world convoy would encounter,” said David Simon, AMAS program manager for Lockheed Martin Missiles and Fire Control. Development and testing of this platform is the result of an $11 million contract awarded to Lockheed Martin by the Defense Department last October.
“Somewhat like the jury-rigged systems seen on the first generation of robotized cars, the AMAS program for the Pentagon’s ground troops uses standard-issue vehicles outfitted with a kit of gear including a high-performance LIDAR sensor and a second GPS receiver, locked and loaded with a range of algorithms,” added Jonathan Skillings of CNET. “That gear, Lockheed said, could be used on virtually any military vehicle, but in these tests was affixed to the Army’s M915 tractor-trailer trucks and to Palletized Loading System vehicles.”
Lockheed Martin explained that the AMAS hardware and software were developed to automate the driving mechanisms on modern-day tactical vehicles. The Unmanned Mission Module portion of this system, which comes equipped with a high performance LIDAR sensor, a second GPS receiver and additional algorithms, comes as part of a kit which can be installed and used on just about any type of military vehicle.
For the purpose of this month’s demonstrations, that kit was integrated onto the Army’s M915 trucks and the Palletized Loading System (PLS) vehicle. Senior officials from the Army Materiel Command (AMC), the Army Capabilities Integration Center (ARCIC), the Combined Arms Support Command (CASCOM) and TARDEC were on hand to witness the demonstration.
“It was very important that we had representation from the technology, acquisition and user bases, along with our industry partners, here at the CAD,” explained TARDEC technical manager Bernard Theisen. “We are very pleased with the results of the demonstration, because it adds substantial weight to the Army’s determination to get robotic systems into the hands of the warfighter.”

DNA Verification Of Peanut Allergy Treatments

Brett Smith for redOrbit.com – Your Universe Online

Scientists with Stanford University are finding that healing a peanut allergy with oral immunotherapy alters the DNA of the patient’s immune cells. The finding could serve as the basis for a simple blood test to monitor the long-term effectiveness of the allergy therapy.

Allergy scientists are currently performing clinical trials of doctor-supervised immunotherapy involving peanut-allergy sufferers taking escalating amounts of peanut powder in an attempt to desensitize them to the nuts. At the conclusion of the trial, patients are usually expected to eat some peanuts every day throughout their lives.

“At first, eating two peanut butter cups a day might seem fun, but it gets a little boring and a lot of people might stop,” said Dr. Kari Nadeau, an immunologist at Stanford Hospital & Clinics and Lucile Packard Children’s Hospital Stanford.

Until now, doctors couldn’t test if patients who had finished immunotherapy could safely give up eating daily doses of peanuts, she said.

“Our new finding can help us try to determine whether, for the long term, someone’s allergy has truly been shut off so people can eat ad lib,” Nadeau said.

In the study, which was published in the Journal of Allergy and Clinical Immunology, the scientists evaluated 20 peanut-allergic adults and children who had concluded two years of immunotherapy, which made it possible for them to eat one 4-gram serving of peanuts daily without experiencing a major allergic reaction.

The patients were asked to stop consuming peanuts for three months and were then given a bit of peanut powder to see if their allergy returned. Thirteen of the patients had a relapse of their allergy, while seven did not. The scientists evaluated the immune cells in the blood of patients from the two groups. Blood samples from peanut-allergic participants who had never acquired the immunotherapy were utilized as a control.

The scientists focused on the regulating T cells, which are white blood cells that help to reduce an allergic reaction. In these cells, the DNA at a gene called forkhead box protein 3 (FOXP3) was somewhat different in each of the three sets of patients. The FOXP3 gene has been previously found to play a role in allergies.

The scientists did not detect transformations in the genetic code. Instead, there were distinctive numbers of methyl groups connected to the DNA. These molecular attachments to the DNA control the pace at which the gene is expressed, turning the thermostat up or down on the gene’s activity. Patients who preserved their tolerance to peanuts had lower levels of DNA methylation at FOXP3, while those who got back their allergy had more moderate levels. Peanut-allergic patients in the control group had a relatively high level of DNA methylation at the FOXP3 gene.

The DNA change may be used to monitor the efficiency of oral immunotherapy, Nadeau said, but needs further evaluating. The blood test vital to monitor the DNA is reasonably priced, requires only a bit of blood and uses common lab equipment. However, Food and Drug Administration validation would be needed before the test might be used clinically for this explicit purpose.

“It’s interesting that the change we saw is at the epigenetic level,” Nadeau said, referring to alterations in genetic activity. “This might help us tell people if they can safely go off of immunotherapy, or if they need to continue to eat the food every day.”

Cold Atom Lab To Study Matter At Near Absolute Zero On The ISS

[ Watch the Video: Getting Cold In Space ]

redOrbit Staff & Wire Reports – Your Universe Online

The coldest spot in the universe will soon be aboard the International Space Station (ISS), as NASA researchers are developing a new device that will allow them to study matter at temperatures nearing absolute zero, the US space agency has announced.

At absolute zero, all of the thermal activity of atoms theoretically halts and the ordinary concepts pertaining to the states of matter are no longer relevant. The new device, the Cold Atom Lab, will ideally create conditions equal to just one ten-billionth of a degree above absolute zero when it launches in 2016.

“We’re going to study matter at temperatures far colder than are found naturally,” explained project scientist Rob Thompson of NASA’s Jet Propulsion Laboratory (JPL) in Pasadena, California. “We aim to push effective temperatures down to 100 pico-Kelvin.”

By studying atoms interacting at that temperature, the researchers could potentially discover new forms of matter and novel quantum phenomena. The branch of physics known as quantum mechanics describes the bizarre rules of light and matter on atomic scales. In this uncertain world that runs on probability, the researchers explained that matter could be in two places at the same time and objects could behave as both particles and waves.

According to Thompson, he and his colleagues will begin by analyzing Bose-Einstein Condensates (BECs), a state of matter of a dilute gas of bosons cooled to near-absolute zero. Under these conditions, the majority of those bosons could occupy the lowest quantum state. If you create two BECs and put them together, they interfere with each other like waves rather than mixing like ordinary gases, the research team explained.

An atom in one BEC can add itself to an atom in another BEC, somehow producing no atom at all, Thompson’s team said. Thanks to the Cold Atom Lab, they will be able to look at this phenomenon at potentially the lowest temperatures ever. They will also be able to mix super-cool atomic gasses and observe the results.

[ Watch the Video: ScienceCasts: The Coolest Spot in the Universe ]

“Mixtures of different types of atoms can float together almost completely free of perturbations, allowing us to make sensitive measurements of very weak interactions. This could lead to the discovery of interesting and novel quantum phenomena,” Thompson said.

“The space station is the best place to do this research. Microgravity allows researchers to cool materials to temperatures much colder than are possible on the ground,” the space agency added. As Thompson explained, quantum gases behave much like regular gases in that they cool when they expand.

With normal gases, when you spray gases in an aerosol can, the can cools. The Cold Atom Lab will use a similar approach, using what is known as a magnetic trap in lieu of the can. On the ISS, Thompson said, the traps can be made weaker since they do not have to deal with gravity’s impact on the atoms. The weaker traps will allow gases to expand and cool to temperatures that are lower than what can be achieved on Earth.

“No one knows where this fundamental research will lead.  Even the ‘practical’ applications listed by Thompson – quantum sensors, matter wave interferometers, and atomic lasers, just to name a few – sound like science fiction,” NASA said. “Researchers like Thompson think of the Cold Atom Lab as a doorway into the quantum world.”

Children Could Benefit From Physical Activity Through Gardening

Peter Suciu for redOrbit.com – Your Universe Online
A garden can grow food, become a thing of beauty, and it can also be good for one’s health. A recent study published the British Journal of Sports Medicine found that gardening – and other simple activities such as home repair – could reduce the risk of a heart attack or stroke and even prolong life by as much as 30 percent among seniors. The study found that these everyday activities could serve as a workout for people of a “certain age” who wouldn’t otherwise get exercise.
A new study has found that this activity, which is usually one reserved for adults, could help children stay fit as well. Researchers in South Korea reported that children can reap the benefits from digging, raking and weeding. It may sound a lot like “chores” that many kids already are required to perform, but the team said that specific garden-based programs could also help engage children in physical activity and promote more healthy lifestyles.
The study, which was conducted by researchers Sin-Ae Park, Ho-Sang Lee, Kwan-Suk Lee, Ki-Cheol Son, and Candice Shoemaker, was recently published in the online journal HortTechnology.
For this study, which was conducted in two South Korean garden environments, the researchers looked at the activities conducted by 17 children as they engaged in 10 specific gardening tasks including: digging, raking, weeding, mulching, hoeing, sowing seeds, harvesting, watering, mixing growing medium and planting transplants.
“The children performed the 10 gardening tasks at a garden previously established in Cheongju, Chungbuk, South Korea,” the authors noted in the paper’s summary. “They visited the garden twice and performed five different tasks on each visit. Five minutes were provided to complete each gardening task and a 5-minute rest was allowed between each task. The children wore a portable telemetric calorimeter and a heart rate monitor for measurement of oxygen uptake and heart rate during the gardening tasks.”
The sensors that the children wore allowed the researchers to measure the activities, and the results suggested that these 10 gardening tasks actually represented moderate- to high-intensity physical activity for the children, with digging and raking being among the most “high intensity” of the physical activities. Other tasks, which included weeding, mulching, hoeing, sowing seeds, harvesting, watering, mixing growing medium and planting transplants were still determined to be “moderate-intensity” physical activities by the researchers.
The researchers believe the findings from the study would be useful information for programs that utilize garden-based therapeutic interventions for children with low levels of physical ability; and moreover could even facilitate the development of future garden-based exercise programs for some children.
Another recent study, conducted by Professor Guy Faulkner at Toronto University found that a small amount of exercise or other physical activity, which would even include just gardening for 30 minutes every day, could be helpful in warding off depression in people of all ages.
A similar study, conducted at the Cooper Research Institute in Dallas, Texas, found that as little as three hours of regular exercise or other physical activity each week could reduce the symptoms of mild to moderate depression as effectively as Prozac or other anti-depressants. It also found that gardening could be a part of daily moderate physical activity and could have a profound impact on treating and even preventing depression.

Iris Aging Controversy In Biometrics

April Flowers for redOrbit.com – Your Universe Online

Will age affect the ability of biometric scanners to recognize your iris or not? This is an important question with an aging American workforce and the increasing reliance on technology for security.

Last year, redOrbit reported that the National Institute of Standards and Technology (NIST) released findings showing that no “consistent change occurs in the distinguishing texture of the iris for at least a decade.” A new study from the University of Notre Dame’s Kevin Bowyer and Estefan Ortiz points out errors of methodology in the NIST report and presents suggestions for revisions to be addressed in future versions of the “IREX VI: Temporal Stability of Iris Recognition Accuracy” report.

The debate rages on, according to Planet Biometrics, because the new NIST results are in direct conflict with several prior research studies from Notre Dame, Michigan State University, Clarkson University, West Virginia University and others. These previous studies analyzed different datasets, and all report observing significant iris template aging effect.

Bowyer, the Schubmehl-Prein Professor and the chair of the Department of Computer Science and Engineering, and Ortiz, a PhD candidate in the same department, point out various flaws in the IREX VI methodology, including using a definition of “iris aging” that is fundamentally different from the ISO standard definition of “iris template aging” used by previous researchers. This new definition is a sub-set of the overall definition. For example, previous studies have attempted to measure change in error rate for iris recognition over time, without excluding any possible cause for the increase in error rate. The IREX VI team, on the other hand, focused only on the change in error rate tied to appearance of the iris, and specifically excluded any changes in the iris related to pupil dilation. Bowyer and Ortiz concede that it is possible for the IREX report to be correct for the sub-set phenomenon that they studied, and the more general iris template aging to also be correct.

The more alarming part of the findings from Notre Dame includes claims of errors of methodology for the IREX report. Bowyer and Ortiz point out errors specifically in the regression analysis.

The first error is that the IREX researchers used a dataset that was “truncated” — meaning that all data points with a value over a certain threshold were deleted. The regression analysis performed on this truncated dataset did not take account of those data points, resulting in an estimate for iris aging that was biased to be lower than it should be in reality.

The second error Bowyer and Ortiz found concerns the regression analysis itself. The researchers assert that the IREX VI report takes one result out of context to represent the effects of iris aging. They say that the effects of aging may, in fact, be present in several results in the IREX VI regression model.

Bowyer and Ortiz point out a third methodology error: the data set used in IREX VI is a mixture of data points resulting from first, second and third attempts at iris recognition in the border-crossing application. This mixture could introduce bias that caused the estimated effect to be smaller than it is in reality.

The Notre Dame team included suggestions for improving a revised IREX VI report, including obtaining a new version of the data set used in the analysis, and using regression analysis methods appropriate to the data set.

Research findings from Notre Dame have played a role in previous IREX reports issued by NIST, including research on the effects of varying pupil dilation on the accuracy of iris recognition is discussed in the IREX I and the IREX III reports.

Lyrica May Ease Pain for Depressed Fibromyalgia Patients

Fibromyalgia is a complex puzzle in which many pieces are still missing.

Of course, the last few years (and decades, in general) have seen an important improvement in the way this syndrome is perceived, but up to the moment, specialists haven’t been able to agree on the exact symptoms and on the exact causes that may lead to its development.

While some of the medical professionals and researchers out there believe that Fibromyalgia is simply impossible to be linked to a very clear set of symptoms, others are still working on deciding which symptoms are typical for Fibromyalgia and which ones develop along with comorbid conditions.

Fibromyalgia is very difficult to diagnose precisely for the reasons described above. Very often, medical professionals will be misled by the development of certain symptoms that are more similar to other conditions and by the fact that patients tend to be very different.

As a matter of fact, the symptoms of certain patients can be so different from what is common that they may not even appear to be anything like Fibromyalgia.

Chronic depression is one of the most common conditions with which Fibromyalgia is both comorbid and which it is very often mistaken. For a very long time, Fibromyalgia has been considered to be an actual form of depression, but nowadays most of the professionals out there will agree that it is a stand-alone condition.

However, some of them still believe that depression can be a cause or a risk factor in the case of those suffering from Fibromyalgia.

The relationship between the two conditions is relatively unknown, although one thing is for sure: they “come” together in the large majority of the cases.

Proper diagnosis is absolutely essential for administering correct treatment. Since Fibromyalgia and chronic depression are so close connected to each other, the treatment prescribed in both of the cases can appear to be quite common.Lyrica May Ease Pain for Depressed Fibromyalgia Patients

Still, in the end, it is pain that will make the difference between the two of them. In most of the cases, patients suffering from depression alone will not need pain killers, but Fibromyalgia patients will most likely need anti-depressants.

Since most of the anti-depressants cannot be taken with powerful analgesics, this can pose an issue for a lot of patients out there. Still, recent studies have shown that Lyrica, a drug produced by Pfizer, can be useful for those suffering from Fibromyalgia and chronic depression together.

It is worth mentioning the fact that this drug is not an anti-depressant proper, and that it works by decreasing the number of signals from the nerves, which can help patients with Fibromyalgia relieve themselves from pain.

Since Fibromyalgia is, as it is most commonly agreed on, a syndrome related to the nerves and how they perceive the pain signals, Lyrica can actually be helpful for those suffering from this syndrome.

Furthermore, Lyrica already has a history of being prescribed for patients with diabetic neuropathy or other types of medical conditions that cause nerve pain.

Up until the moment, two major tests have been run to see if Lyrica can become a treatment for those with Fibromyalgia. Both of them showed the same results, but the second one is different because it was run on patients who were also taking antidepressants.

In both of the cases, Lyrica appeared to show positive outcomes and the FDA (Food and Drug Administration) has already approved it as a drug that can be prescribed for this syndrome.

In addition with helping with the pain relieving process, Lyrica can help Fibromyalgia patients in other ways as well. For instance, it can have a calming effect and it can ease the troubled sleep of these people. Patients on whom Lyrica has a beneficial effect have been able to do what they used to do when they weren’t suffering from this syndrome.

However, you should bear in mind that Lyrica is a prescription drug for a reason and that it may not be good for you. If you suffer from other medical conditions and you are taking drugs for it, Lyrica can become dangerous and you should tell your doctor about every kind of drug you have been previously prescribed.

For example, blood pressure drugs combined with Lyrica can lead to swelling and hives, while some diabetes drugs can cause weight gain and swelling as well if they are taken with Lyrica.

Furthermore, drinking alcohol when on Lyrica is completely forbidden and driving while on the same drug can become dangerous, since it can cause dizziness, sleepiness and it can draw your attention from the road.

Fruit Flies Offering Clues About An Astronaut’s Immune System

Lee Rannals for redOrbit.com – Your Universe Online
Researchers, publishing a paper in the journal PLOS ONE, say fruit fly studies could give insight into how microgravity impacts an astronaut’s immune system.
A team from the University of California at Davis and the University of Central Florida studied how fruit flies handle being in microgravity. Fruit flies have a similar immune system to that of humans and other mammals, so it makes them a great subject to study the impact of weightlessness on our immune system.
Zero gravity can have negative impacts on muscle, bone mass and the immune system, but so far scientists have been puzzled as to why. The latest study shows one way in which the immune system may suffer from a microgravity environment.
The team bred flies in space while aboard the Space Shuttle Discovery in 2006 and waited as the flies developed into adults during the 12-day mission. Once the mission landed scientists retrieved the flies and subsequently found they were more apt to get fungal infections.
“Our study showed that a biochemical pathway needed to fight fungal infections is seriously compromised in the flies after space flight,” Laurence Von Kalm, a UCF biologist who worked on the study, said in a statement. “More work will be needed to determine if similar effects occur in humans, but this gives us some clues. Getting a better understanding is particularly important, especially as we look to engage in long-term missions such as interplanetary space flights.”
The researchers also found that the system the flies use for detecting and defending against fungal infection was deactivated. However, another system used to defend against bacterial infections did not suffer during the space flight.
“We speculate on possible linkage between functional Toll signaling and the heat shock chaperone system. Our major findings are that hypergravity and spaceflight have opposing effects, and that spaceflight produces stress-related transcriptional responses and results in a specific inability to mount a Toll-mediated infection response,” the team wrote in the journal.
Understanding the impacts of microgravity on our body is crucial to knowing what astronauts should expect for long-duration missions, such as traveling to Mars or an asteroid. The researchers hope to continue this study by bringing the experiment to the International Space Station.