New Study Finds No Reason To Replace Fructose With Glucose

Researchers at St. Michael’s Hospital have found there is no benefit in replacing fructose, the sugar most commonly blamed for obesity, with glucose in commercially prepared foods.

The findings, published in the February edition of Current Opinion in Lipidology, show that when portion sizes and calories are the same, fructose does not cause any more harm than glucose.

“Despite concerns about fructose’s link to obesity, there is no justification to replace fructose with glucose because there is no evidence of net harm,” said Dr. John Sievenpiper, a researcher in the Clinical Nutrition and Risk Factor Modification Centre of St. Michael’s.

Using data from previous research trials, Dr. Sievenpiper and his team compared the effects of fructose and glucose against several health risk factors. The study found that consuming fructose may increase total cholesterol and postprandial triglycerides, a type of fat found in blood. However, fructose did not appear to affect insulin production, other fat levels in the blood stream or markers of fatty liver disease any more than glucose did.

In fact, fructose showed potential benefits over glucose in some key risk factor categories.

“Some health care analysts have thought fructose to be the cause of obesity because it’s metabolized differently than glucose,” said Dr. Sievenpiper. “In calorie-matched conditions, we found that fructose may actually be better at promoting healthy body weight, blood pressure and glycemic control than glucose.”

Fructose, a simple sugar found in honey, fruit, vegetables and other plants, is also the basis of high-fructose corn syrup – a sweetener often found in commercially prepared foods. The combination of both fructose and glucose produces sucrose, generally known as table sugar.

Dr. Sievenpiper said he feels that overconsumption, rather than a type of sugar, is one of the leading causes of obesity.

“Overall, it’s not about swapping fructose with glucose,” said Dr. Sievenpiper. “Overeating, portion size and calories are what we should be refocusing on – they’re our biggest problems.”

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Russia’s Love Of Vodka Drives Premature Death Rates In Men

Brett Smith for redOrbit.com – Your Universe Online
Vodka has long been a part of Russian culture and that culture needs to change if the country wants to save the lives of thousands of its people.
According to a new study published in The Lancet, vodka is a major cause of the high risk of premature death in Russian adults  – with a quarter of all Russian men dying before reaching 55.
“Russian death rates have fluctuated wildly over the last 30 years as alcohol restrictions and social stability varied under Presidents Gorbachev, Yeltsin, and Putin, and the main thing driving these wild fluctuations in death was vodka,” study author Richard Peto, an epidemiologist from the University of Oxford, told BBC News‘ Tulip Mazumdar.
In 1985, laws enacted under Soviet Premier Mikhail Gorbachev drastically cut vodka manufacturing and did not permit it to be sold before lunch-time. The study team said alcohol intake fell by around 25 percent when the restrictions came in, and so did overall death rates. Then, when communism faded, people began drinking more – causing the death rate to rise yet again.
“When President Yeltsin took over from President Gorbachev, the overall death rates in young men more than doubled. This was as society collapsed and vodka became much more freely available,” Peto said. “There was a huge increase in drinking and they were drinking in a destructive way. They were getting drunk on spirits and then buying and drinking more, producing a big risk of death.”
The research team noted the usage rates for women also changed with the politics, but women drank less on average so fatality rates for them were also reduced.
Many drinkers were smokers as well, which scientists said “aggravated” the fatality rates. Russia introduced stricter alcohol control actions in 2006, including increasing taxes and limiting sales. The study team said alcohol intake has dropped by a third since then and the percentage of men dying before they reach 55 years old has decreased from 37 percent to 25 percent. In 2011, each Russian adult consumed an average of nearly 3 gallons of pure alcohol each year, of which 1.8 gallons was in spirits, mainly vodka.
The study team said the main issue driving the high mortality rate is the way Russians drink alcohol.
“They binge drink. That’s the main problem,” said study author David Zaridze, from the Russian Cancer Research Centre. “It’s the pattern of drinking not the per-capita amount they are drinking.”
“Russians have always drunk a lot,” Zaridze continued. “They sometimes say it’s because of the cold weather but this is just an excuse. This is the nation’s lifestyle that needs to change.”
“Since the average life expectancy from birth for men in Russia is still only 64 years, ranking among the lowest 50 countries in the world, more effective alcohol and tobacco policy measures are urgently needed,” he concluded.
Heavy drinking is so ingrained in Russian culture – they even have a word for a multiple-day drinking bender – “zapoi.”

Secrets Of Potato Blight Evolution Could Aid Farmers In Fighting Back

University of Oxford
Scientists have discovered vital clues as to how the pathogen responsible for the Irish potato famine adapted to spread between different plant species.
Researchers at Oxford University and The Sainsbury Laboratory (Norwich, UK) looked in unprecedented detail at how Phytophthora infestans, a pathogen that continues to blight potatoes and tomatoes today, evolved to target other plants.
The study, published today in the journal Science, is the first to show how pathogens switch from targeting one species to another through changes at the molecular level. Researchers examined the biochemical differences between Phytophthora infestans and sister species Phytophthora mirabilis, a pathogen that split from P. infestans around 1300 years ago to target the Mirabilis jalapa plant, commonly known as the four o’clock flower. They found that each pathogen species secretes specialized substances to shut down the defenses of their target hosts.
‘Plants have these enzymes called proteases that play a key role in their defence systems,’ said Dr Renier van der Hoorn, co-author of the study from Oxford University’s Department of Plant Sciences. ‘When a plant becomes infected, proteases help plants to attack the invading pathogens and trigger immune responses. P. infestans secretes substances called effectors that disable proteases in potatoes and tomatoes. These are highly specialized to block specific proteases in the host plant, fitting like a key into a lock.’
The effectors secreted by P. infestans are less effective against proteases in other plants such as the four o’clock, as they do not fit well into the ‘locks’. The researchers found that P. mirabilis evolved effectors that disable the defenses of the four o’clock plant but are no longer effective against potatoes or tomatoes.
“For the first time, we have found a direct molecular mechanism underpinning the change in host specialisation,” said Dr van der Hoorn. “We looked at specialisation in the blight pathogens’ secret weapon, a key family of effectors called ‘EPIC’ that can pass through plants’ defences undetected to disable the proteases. The EPIC effectors secreted by P. infestans have evolved to fit the structure of potato proteases just as P. mirabilis has evolved effectors that fit four o’clock proteases.
“If we could breed plants with proteases that can detect these stealthy EPIC effectors, we could prevent them from ‘sneaking in’ and thus make more resistant plants. Within the next decade, we plan to exploit the specialized nature of these effectors to develop proteases that are resistant to their action or can even trap them and destroy the pathogen. Potato and tomato plants with such proteases would be resistant to the blight pathogens, and combined with other resistant traits could provide another ‘wall’ of defence against the pathogens.”

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Drugged Driving Fatalities On The Rise

April Flowers for redOrbit.com – Your Universe Online

The number of fatally-injured drivers in the US that test positive for non-alcohol drugs has been steadily rising. From 1999 to 2010, the number tripled for drivers who tested positive for marijuana, which is the most commonly detected non-alcohol drug. This increase suggests that drugged driving may be playing an increasing role in fatal motor vehicle collisions.

Researchers at Columbia University’s Mailman School of Public Health used toxicological testing data from the National Highway Traffic Safety Administration’s Fatality Analysis Reporting System to understand these trends. The research team looked at 23,591 drivers who died within one hour of the crash, finding that 39.7 percent tested positive for alcohol and another 24.8 percent tested positive for other drugs. The results showed that the alcohol-related deaths remained stable, while the prevalence of non-alcohol drugs rose significantly — from 16.6 percent in 1999 to 28.3 percent in 2010. For marijuana specifically, fatality rates rose from 4.2 percent to 12.2 percent.

The study, published online in the American Journal of Epidemiology, is based on data collected from six states that routinely perform toxicological testing on drivers involved in fatal crashes. The six states are California, Hawaii, Illinois, New Hampshire, Rhode Island, and West Virginia.

According to the findings, men were more prone to alcohol being involved (43.6 percent) than women (26.1 percent), although the trends remained stable for both sexes. The substantial increase in marijuana, in contrast, was consistent across all ages and genders.

“Although earlier research showed that drug use is associated with impaired driving performance and increased crash risk, trends in narcotic involvement in driver fatalities have been understudied,” said Guohua Li, MD, DrPH, professor of Epidemiology and Anesthesiology and director of the Center for Injury Epidemiology and Prevention. “Given the increasing availability of marijuana and the ongoing opioid overdose epidemic, understanding the role of controlled substances in motor vehicle crashes is of significant public health importance.”

Prior research from 2003 to 2013 revealed an increase in drivers testing positive for marijuana in roadside surveys, according to Joanne Brady, PhD candidate in epidemiology, as well as for California drivers involved in fatal accidents. Marijuana use also increased in Colorado during this time among patients treated in healthcare settings. “The marked increase in its prevalence as reported in the present study is likely germane to the growing decriminalization of marijuana,” noted Ms. Brady. During the last two decades, 20 states and Washington, DC have enacted legislation to decriminalize marijuana for medical use, and four more states have legislation pending. “Although each of these states has laws that prohibit driving under the influence of marijuana, it is still conceivable that its decriminalization may result in increases in crashes involving marijuana.”

The authors note that while their results provide evidence that non-alcohol drugs in fatally injured drives has increased significantly, there are some limitations to the results that must be considered. The study is based on data collected in only six states, and the effects of drugs on driving performance and crash risk vary by drug type, dosage, and the driver’s physiological response and tolerance level. Another limit of the data is that it is possible to test positive for marijuana in the blood for up to one week after use.

Dr. Li said, “it is important to interpret the prevalence of non-alcohol drugs reported in this study as an indicator of drug use but not necessarily as a measurement of drug impairment. To control the ongoing epidemic of drugged driving, it is imperative to strengthen and expand drug testing and intervention programs for drivers.”

Effects Of Catch-and-release Fishing On Sharks Examined

[ Watch The Video: Catch-And-Releasing Sharks ]

University of Miami Rosenstiel School of Marine & Atmospheric Science

Researchers analyze blood chemistry, reflexes, and post-release survival of five coastal shark species in South Florida

A new study led by scientists at the University of Miami (UM) Abess Center for Ecosystem Science and Policy and the Rosenstiel School of Marine and Atmospheric Science investigated how several species of coastal sharks respond to stress from catch-and-release fishing. The results revealed that each of the shark species responded differently. Hammerhead sharks were by far the most vulnerable to fighting on a fishing line.

The UM scientists experimentally simulated catch-and-release fishing on five shark species – hammerhead, blacktip, bull, lemon and tiger sharks – in South Florida and Bahamian waters. Researchers took blood samples to examine stress, including pH, carbon dioxide and lactate levels, conducted reflex tests, as well as used satellite tags to look at their post-release survival. Fighting on a fishing line significantly affected the blood lactate levels of sharks, similar to what happens to humans during intense or exhaustive physical exercise, which has been linked to mortality in many species of fish. The study revealed that even with minimal degrees of fighting on a fishing line, hammerhead exhibited the highest levels of lactic acid build of all species studied, followed by blacktip, bull, lemon and tiger sharks. Tagging results also suggested that, after release, hammerheads were also prone to delayed mortality.

“Our results show that while some species, like tiger sharks, can sustain and even recover from minimal catch and release fishing, other sharks, such as hammerheads are more sensitive” said lead author and Abess Center Ph.D candidate Austin Gallagher. “Our study also revealed that just because a shark swims away after it is released, doesn’t mean that it will survive the encounter. This has serious conservation implications because those fragile species might need to be managed separately, especially if we are striving for sustainability in catch and release fishing and even in bycatch scenarios.”

Adds study co-author Dr. Neil Hammerschlag, a Research Assistant Professor at UM, “Many shark populations globally are declining due to overfishing. Shark anglers are some of the biggest advocates for shark conservation. Most have been making the switch from catch and kill to all catch and release. Our study helps concerned fisherman make informed decisions on which sharks make good candidates for catch and release fishing, and which do not, such as hammerheads.”

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Long-awaited Synthetic Particle Discovered By Scientists

Aalto University

Researchers at Aalto University and Amherst College have now created and photographed synthetic magnetic monopoles under laboratory conditions. These observations lay the foundation for the underlying structure of the natural magnetic monopole – the detection of which would be a revolutionary event comparable to the discovery of the electron. The results were recently published in Nature magazine.

Although predicted over 80 years ago, the fundamentally quantum-mechanical configuration of the monopoles has not previously been observed in any physical system. The reported results demonstrate the structure in an ultracold atomic gas.

“Our achievement opens up amazing avenues for quantum research. It feels incredible to have been a part of such a major breakthrough,” says a delighted Dr. Mikko Möttönen from Aalto University, Finland.

Evidence for magnetic monopoles has been sought in sources as diverse as lunar samples and ancient micas. The multibillion-euro LHC particle accelerator at CERN has also been used in the search – but no magnetic monopoles have been convincingly identified. The discovery of the synthetic monopole provides a stronger foundation for these efforts.

“The creation of a synthetic magnetic monopole should provide us with unprecedented insight into aspects of the natural monopole,” says Prof. David S. Hall from Amherst College, USA. “It’s not every day that you get to poke and prod the analogue of an elusive fundamental particle under highly controlled conditions in the laboratory,” he continues.

“Synthesis of the monopole is the starting point for many new breakthroughs in quantum physics research. In the future, we want to get even a more complete correspondence with the natural magnetic monopole,” says Dr. Möttönen.

A magnetic monopole is a particle just like an electron, but with a magnetic rather than an electric charge. Some 80 years ago Paul A. M. Dirac, one of the founders of quantum physics, discovered a quantum-mechanical structure allowing the existence of magnetic monopoles. Dirac’s original framework has now been experimentally realized for the first time.

[ Watch The Video: Monopole Creation ]

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Google’s Latest Gmail Glitch May Have Deleted Your Emails

Peter Suciu for redOrbit.com – Your Universe Online

This week search giant Google reported that it had resolved a glitch that may have caused some incoming emails to its Gmail service to be marked as spam while other emails were simply deleted. On Tuesday the company assured users this bug was fixed, but encouraged users to carefully monitor their incoming email for the next couple of weeks.

Some Gmail users received the following notification, as first reported by the Verge:

“You may have been impacted by a recent issue in Gmail that inadvertently caused some actions (e.g. delete, report spam) taken while viewing a message to be applied to a different message. The issue occurred between January 15 and January 22 and is now fixed.”

“We encourage you to check your Trash and Spam folders before February 14, 2014 for any items you did not intend to delete or mark as spam and move them back to your inbox. We apologize for any inconvenience.”

According to online reports this particular outage occurred following a software update on a few Gmail platforms that included the iOS app, the mobile browser version or the offline version of Gmail. However, this particular snafu apparently wasn’t all that widespread.

Google has since announced this issue did not affect all users, and it has been fixed. To date it is still not clear exactly how many users may have had emails inadvertently marked as spam or simply deleted. As noted, the company has encouraged all users to check trash and spam folders to ensure that no email was inadvertently deleted or marked as spam.

This also was not the only glitch that Gmail users have experienced this month. On January 24, Gmail along with other Google services actually went down for approximately 10 percent of users, and the particular outage lasted for nearly half an hour. The search giant attributed this to a piece of buggy code.

“Earlier today, most Google users who use logged-in services like Gmail, Google+, Calendar and Documents found they were unable to access those services for approximately 25 minutes,” Ben Treynor, vice president of engineering at Google, posted on the company’s blog. “For about 10 percent of users, the problem persisted for as much as 30 minutes longer. Whether the effect was brief or lasted the better part of an hour, please accept our apologies—we strive to make all of Google’s services available and fast for you, all the time, and we missed the mark today.”

“The issue has been resolved, and we’re now focused on correcting the bug that caused the outage, as well as putting more checks and monitors in place to ensure that this kind of problem doesn’t happen again,” Treynor added. “If you’re interested in the technical explanation for what occurred and how it was fixed, read on.”

Reports of the most recent outage hit Twitter at 2pm ET, and apparently it affected Gmail as well as Google+ and Google Hangouts. While the official statement from Google claimed this disruption lasted 25 minutes, PC Mag reported the Gmail problem was only fixed by 3:23pm with the issues for Google+ and Hangouts lasting about another 10 minutes. That suggests the outage may have lasted more than a hour.

For some users it no doubt felt like an eternity.

Natural Remedies to Relieve the Symptoms of Fibromyalgia

Natural Remedies to Relieve the Symptoms of Fibromyalgia

Fibromyalgia is a syndrome that is as little known as it is painfully real. Just a few decades ago, this syndrome was considered to be either simply inexistent, or just a form of depression.

Nowadays though, most of the professionals out there agree that Fibromyalgia is a syndrome in itself and that there may be a wide variety of causes to trigger its development.

When it comes to these causes, opinions are split among the medical professionals. Some simply say that there is no actual cause, while some link the development of this syndrome with the levels of serotonin in the brain.

Also, some of the specialists believe that Fibromyalgia is linked to a traumatic event, stress, and other types of illness and/or that the hereditary factors may play a very important part.

Although its causes may be relatively unknown, and its symptoms may sometimes be as confusing as the causes, one thing is sure about Fibromyalgia: its symptoms can be relieved.

Most of the times, the doctors will recommend a combination of drugs and alternative remedies to help patients relieve themselves from pain, depression, anxiety, sleep issues and the other symptoms and disorders that are commonly linked to Fibromyalgia.

While the prescription of drugs is up to the doctor and you cannot do anything about it on your own, the other half of the prescriptions may help you in ways you did not think it was possible. Natural remedies can have an amazing effect on Fibromyalgia patients and, believe it or not, they can actually relieve you from pain.

One of the most common and easiest things you can do is to change your diet. Although unhealthy eating may not be an actual trigger of this syndrome, it can worsen its symptoms considerably. Foods containing additives, for instance, may irritate the bowels and if your bowels are already irritable, you will most likely want to avoid anything that may make it worse.

Furthermore, coffee, caffeinated products and sweets may make you feel good for a short amount of time and they may make you feel like making up for the sleepless nights, but in the end, they will only worsen your sleep issues and they will push you into a vicious cycle.

Instead, put a lot of emphasis on fatty acids contained by olive oil, fatty fish (salmon, tuna), nuts, and so on. These foods will give you a general state of well-being, you will start feeling more energized and your body will be in a better state.

Furthermore, there is a series of herbs that may ameliorate various Fibromyalgia symptoms. For instance, chamomile tea can be extremely relaxing and it can help you fall asleep easier. Lavender oil can have the same effect and so can the passionflower.

Other herbs, for instance, may have an energizing effect, but you will have to make sure not to use them other time than the mornings, since you do not want to be energized right before bedtime.

What may surprise you is the fact that cayenne pepper can act as an analgesic and that, as long as you use it with measure, it can help relieving you from pain. Furthermore, there are creams and oils based on cayenne pepper that, applied on the painful area, will help with the pain as well, since it will help increasing the circulation and it will warm up the area.

Ginger and ginseng will also have analgesic effects and they are quite well-known for that. Even more, they are very healthy additions to your diet even when you don’t suffer from Fibromyalgia.

Another natural remedy you can take benefit from is exercising. Of course, it will have to be of a low impact, but as long as you do not strain yourself too much, there will only be good things coming out of it.

A bit of stretching or low-impact yoga can help releasing endorphins and it can help with the muscle pain. Make sure you do talk to your doctor about this though and that you will not force your body too much since you can achieve the exact opposite if you do so.

Oriental remedies, such as acupuncture and Tai-Chi, are also believed to relieve patients from a series of Fibromyalgia symptoms (and pain is the most important of them). If you are willing to try these out, you may discover that they are actually very beneficial for you.

The most important thing is to stay positive though. A positive attitude will help you get through more graciously. Furthermore, you will be less inclined to feel depressed and anxious and that will help a lot with the development of your treatment!

Migrating Monarch Butterfly Numbers Are At A Record Low

[ Watch the Video: Where Have All The Monarchs Gone? ]

April Flowers for redOrbit.com – Your Universe Online

A new report, based on a December 2013 survey of Mexico’s Monarch Butterfly Biosphere Reserve, claims that migrating monarch butterflies are in “grave danger.” The butterfly colonies currently occupy the smallest area since records began in 1993.

The butterflies spend their winter hibernating in the forest of the reserve. In December 2013, the butterflies only occupied 1.65 acres. National Geographic reports that this represents a 44 percent drop from 2012 when they covered 2.76 acres of land. Additionally, the Associated Press (AP) reports that at the peak of recorded populations, the butterflies covered more than 44.5 acres in 1996.

Monarch butterflies are found in many parts of the world, including North and South America, Australia, New Zealand, and many South Pacific Islands. The most studied subspecies, however, is the migratory monarch, since it is the group at most risk.

“The monarch butterfly as a species is not endangered. What is endangered is its migratory phenomenon from Canada to Mexico and back,” noted Omar Vidal, director of WWF-Mexico, in an email to National Geographic reporter Christine Dell’Amore.

There are a few reasons  why migrating monarch numbers are falling: widespread loss of a plant called milkweed, which their young rely on for food; extreme climate fluctuations in North America, including freezing temperatures and heavy rain; and deforestation. The loss of these populations could spell disaster for many ecosystems because monarchs pollinate plants, including corn, that humans rely on for food.

Researchers have been seeing this decline for the past three years. “Data from previous time periods usually show a pattern of ups and downs,” Karen Oberhauser, a monarch expert at the University of Minnesota in Minneapolis, told Dell’Amore. Oberhauser worries the survey may be underestimating the population loss.

The monarch butterfly weighs in between 0.0095 to 0.026 ounces. The most noteworthy aspect of the insect, however, is the annual migration. Every autumn, millions of butterflies head south and west from Canada and the US, headed to Mexico. They stop at sites along the way to breed and feed. The butterflies who migrate one year are not the ones who arrived in Mexico the year before. The migration covers thousands of miles, and spans five generations of butterflies to complete.

Most adult butterflies live only one month. The fifth generation, however, are different. They live approximately seven to eight months, which is just enough time to make the trip from Canada or the US to central Mexico where they hibernate in the Mexican states of Michoacan and Mexico. These hibernation grounds were discovered in 1976 by Dr. Fred A. Urquhart and a team of volunteers.

Milkweed is a necessary ingredient in the monarch’s lifecycle and migration. It is the only plant they will lay their eggs on, and the newly hatched larvae eat the plant as their first meal.

The problem is that milkweed is not popular with farmers and ranchers because it is poisonous to livestock. The weed was once widespread throughout the United States, but today it only holds 58 percent of its historical range due to herbicide use, especially on corn and soybean fields.

According to AP reporter Mark Stevenson, Lincoln Brower, a leading entomologist at Sweet Briar College in Virginia, wrote that “the migration is definitely proving to be an endangered biological phenomenon.”

“The main culprit,” he wrote in an email to Stevenson, is now genetically modified “herbicide-resistant corn and soybean crops and herbicides in the USA,” which “leads to the wholesale killing of the monarch’s principal food plant, common milkweed.”

The butterflies are also threatened by climate extremes, such as the droughts, heat waves, and storms that have hit North America in recent years. Monarch numbers were very low in 2005 and 2006, which has been attributed to a severe drought in the US.

The final threat to the butterflies is logging, both in Mexico and the US. Loss of habitat on both ends of the migration is squeezing the population into smaller and smaller areas.

Oberhauser said there are ways to halt the decline by recruiting the help of all three North American countries, although she admits this will not be easy.

She notes that one strategy would be incorporating milkweed into large scale plantings wherever possible—including marginal lands like roadsides.

Gardeners in North America can also contribute to conservation efforts by planting milkweed and making their gardens more butterfly-friendly.

“Given the conservation challenges facing monarchs, it’s vitally important that we mobilize as many people as possible,” Oberhauser said. “Through our collective efforts, monarch populations can rebound, so that their migrations may be appreciated by many generations to come.”

The survey’s results were announced shortly after the 20th anniversary of the North American Free Trade Agreement (NAFTA), in which Canada, the US and Mexico signed environmental accords to protect migratory species such as the monarch. The butterfly was adopted as the symbol of the trilateral cooperation.

President Obama is scheduled to visit Mexico on February 19, with events in Toluca, a city just a few dozen miles from the butterfly reserve.

“I think President Obama should take some step to support the survival of the Monarch butterflies,” writer and environmentalist Homero Aridjis, who has been a lifelong proponent of the monarch, told Stevenson. “The governments of the United States and Canada have washed their hands of the problem, and left it all to Mexico.”

Mexico’s National Commission for Protected Areas collaborated in the survey with World Wildlife Fund (WWF) Telcel Alliance.

23andMe Helps Find New Genetic Associations For Asthma-With-Hay Fever

23andMe

First Ever Genome-Wide Association Study of Combined Phenotype May Allow for Improved Identification of Variants Associated with Asthma-With-Hay Fever

23andMe, the leading personal genetics company, has participated in the first ever genome-wide association study of the combined asthma-with-hay fever phenotype.  Led by researchers at the QIMR Berghofer Medical Research Institute, the study identified 11 independent genetic markers associated with the development of asthma-with-hay fever, including two associations reaching a level of significance with allergic disease for the first time. Through these findings, 23andMe aims to substantially improve the ability to detect genetic risk factors shared between both diseases.

Previous research has shown that both asthma and hay fever share 50-90 percent of their genetic susceptibility and 20-50 percent of their environmental susceptibility. 23andMe has collected information on both conditions through its asthma symptoms survey, and in this analysis used data contributed by 15,072 of its customers. Data was also collected from three additional studies conducted in Australia and the United Kingdom, with cases defined as persons who reported a physician diagnosis of asthma and also hay fever (total N=6,685). This group was compared to a control group of individuals who reported neither a diagnosis of asthma or hay fever (total N=14,091).

“While previous analyses provided evidence of a stronger genetic association of this combined phenotype, there has not been a genome-wide association study exploring the connection in further detail,” said David Hinds, Ph.D., study author and 23andMe principal scientist, statistical genetics. “In this first-of-its-kind study, we’ve identified new genetic associations that can provide the means to identify people at risk for allergic disease with greater efficiency.”

By considering the phenotype of asthma-with-hay fever, 11 independent variants with genome-wide significant associations with disease risk were identified, amongst which were variants in the 8q21 and 16p13 regions, which have now been established as containing genetic risk factors for allergic disease. The study also found that genetic risk factors for allergic disease are located in or near variants ZBTB10 and CLEC16A. Further investigations of the entities underlying both associations may help identify previously unrecognized pathways in the development of asthma and hay fever.

The study, titled “Genome-wide association analysis of the phenotype asthma-with-hay fever for 20,000 persons identified 11 risk loci, including variants near ZBTB10 and CLEC16A” was published on January 2, 2014 in the Journal of Allergy and Clinical Immunology.

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Animal Model Demonstrates Role For Metabolic Enzyme In Acute Myeloid Leukemia

Genetically engineered mouse model validates the mutant IDH2 protein as candidate for targeted anticancer therapies; provides new tool for future investigations

In recent years, mutations in two metabolic enzymes, isocitrate dehydrogenase-1 and 2 (IDH1 and IDH2), have been identified in approximately 20 percent of all acute myeloid leukemias (AML). As a result, mutant IDH proteins have been proposed as attractive drug targets for this common form of adult leukemia.

Now a scientific team at Beth Israel Deaconess Medical Center (BIDMC) has generated a transgenic mouse model of the most common IDH2 mutation in human AML, and, in the process, answered a central question of whether these mutant IDH proteins are required for leukemia initiation and maintenance in a living organism.

Currently published on-line in the journal Cell Stem Cell and scheduled to appear in print in March, these new findings confirm a potent oncogenic role for IDH2, and support its relevance as a therapeutic target for the treatment of this widespread blood cancer. Equally important, this transgenic model provides an important new tool for evaluating the pharmacological efficacy of potential mutant IDH2 inhibitors, either alone or in combination with other compounds.

“The real hope is that we would one day be able to treat IDH2-mutant leukemia patients with a drug that targets this genetic abnormality,” explains senior author Pier Paolo Pandolfi, MD, PhD, Director of the Cancer Center and the Cancer Research Institute at BIDMC and the George C. Reisman Professor of Medicine at Harvard Medical School. “Our transgenic animal model has now demonstrated that the IDH mutation contributes to the initiation of acute leukemia in vivo and that mutant IDH is essential for the maintenance of leukemic cells even in a genetic setting where mutant IDH is not required for cancer initiation.”

IDH1 and IDH2 proteins are critical enzymes in the TCA cycle, which is centrally important to many biochemical pathways. Mutated forms of these proteins gain a novel ability to produce 2-hydroxyglutarate (2HG), a metabolite that has been shown to accumulate at high levels in cancer patients and is therefore described as an “oncometabolite.”

“Our goal was to generate an animal model of mutant IDH that was both inducible and reversible,” explains co-lead author Markus Reschke, PhD, an investigator in BIDMC’s Cancer Research Institute and Research Fellow in the Pandolfi laboratory. “This enabled us to address an important unanswered question: Does inhibition of mutant IDH proteins in active disease have an effect on tumor maintenance or progression in a living organism?”

Reschke and co-lead author Lev Kats, PhD, also a Research Fellow in the Pandolfi lab, studied two different models: a retroviral transduction model and a genetically engineered model in which IDH mice were crossed to mice harboring other leukemia-relevant mutations.

In the first model, the IDH mutation was combined with the oncogenes HoxA9 and Meis1a, two downstream targets of numerous pathways that are deregulated in AML. The results showed evidence of differentiation within two weeks of genetic deinduction of mutant IDH, and two weeks later, six of eight animals showed complete remission with elimination of any detectable leukemic cells.

These results, say the authors, were both surprising and encouraging, demonstrating a situation in which IDH mutation occurs as an early event and leukemic transformation occurs as a result of subsequent genetic “hits.”

“The retroviral model enabled us to observe that mutant IDH2 is essential for the maintenance of HoxA9/Meis1a-induced AML,” explains Kats. “But this was still a surrogate model – this isn’t what happens in human patients, per se.”

The investigators, therefore, went on to develop a transgenic model that more closely recapitulates the genetics of human AML.

“By crossing the mutant IDH2 animals with other leukemia-relevant mutations, including mutations in the FMS-like tyrosine kinase 3 [FLT3], we observed that compound mutant animals developed acute leukemias,” explains Reschke. “This exciting finding told us that mutant IDH2 contributes to leukemia initiation in vivo.” As with the retroviral transduction model, genetic deinduction of mutant IDH2 in the context of a cooperating Flt3 mutation resulted in reduced proliferation and/or differentiation of leukemic cells, further demonstrating that mutant IDH2 expression is required for leukemia maintenance.

“This model has validated mutant IDH proteins as very strong candidates for continued development of targeted anticancer therapeutics,” says Pandolfi. “The model will also be of paramount importance to study mechanisms of resistance to treatment that may occur.”

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Controversial Scientist Sues NASA For Not Investigating Alien Life

Brett Smith for redOrbit.com – Your Universe Online

Last week, NASA released images from its Mars rover Opportunity of a strange looking rock that was not in pictures taken weeks earlier of the same swath of Martian surface. The “sudden” appearance of the rock spurred speculation that the rock was in fact an alien life form.

While, NASA quickly dismissed speculation by saying the rock was simply kicked out by one of Opportunity’s wheels or knocked toward the rover by a nearby impact – theories persisted and now an author and self-described scientist is suing NASA over its failure to investigate the potential discovery of alien life.

Aimed at NASA and its administrator Charles Bolden, the lawsuit filed by Rhawn Joseph is calling for the space agency to “perform a public, scientific, and statutory duty which is to closely photograph and thoroughly scientifically examine and investigate a putative biological organism.”

The images at the center of the lawsuit are from Opportunity’s panoramic camera (Pancam): one from 3,528th Martian day, or sol, which was taken on Dec. 26, 2013, and one from Sol 3540, taken on Jan. 8, 2014. The rock is mostly white, with a portion that is deep red in color. Some have compared it to a smashed jelly donut. The images were taken on Murray Ridge, a section of the rim of Endeavour Crater where Opportunity is working on north-facing slopes during the rover’s sixth Martian winter.

The lawsuit asserted that the “rock” is actually a living organism that grew until it became visible.

“(W)hen examined by Petitioner the same structure in miniature was clearly visible upon magnification and appears to have just germinated from spores,” the suit said. “The refusal to take close up photos from various angles, the refusal to take microscopicimages [sic] of the specimen, the refusal to release high resolution photos, is inexplicable, recklessly negligent, and bizarre.”

Joseph has contacted multiple NASA officials, but received no response, according to the lawsuit.

“Petitioner has specifically requested and has demanded in writing the following of NASA, NASA’s chief administrator Bolden, and NASA’s rover team: A) take 100 high resolution close-up infocus [sic] photos of the specimen identified in Sol 3540, at various angles, from all sides, and from above down into the “bowl” of the specimen, and under appropriate lighting conditions which minimize glare. B) Take a minimum of 24 microscopic in-focus images of the exterior, lip, walls, and interior of the specimen under appropriate lighting conditions. C) NASA, and the rover team must make public and supply Petitioner with all high resolution photos and images of that specimen as demanded in A and B,” the suit said.

Last week, a newly published study based on data collected from the Opportunity rover found that an ancient wet environment existed on Mars that was milder and older than the acidic and oxidizing conditions told by rocks the rover examined previously.

“These rocks are older than any we examined earlier in the mission, and they reveal more favorable conditions for microbial life than any evidence previously examined by investigations with Opportunity,” said study author Ray Arvidson, a professor at Washington University in St. Louis.

Supplements and vitamins for fibromyalgia

Fibromyalgia is a syndrome that is very little understood even nowadays and even by medical professionals. Mysterious and still not completely known, this syndrome affects millions of Americans and it influences the way they live their lives: from how they wake up, to what they eat and to their daily activities.

There are a lot of symptoms that appear with Fibromyalgia, and some of them have also been considered to be causes and risk factors. The entire image of this syndrome is, in general, quite foggy, and this is precisely what makes it so hard to diagnose and so difficult to treat.

From depression to joint pain and from losing cognitive abilities to digestive issues, Fibromyalgia patients can experience a wide range of symptoms and each patient can be special.

Thus, once a medical professional has put the Fibromyalgia diagnosis, he/she will also prescribe the patient a combination of drugs and remedies that he/she can apply. All these suggestions are made according to the most common causes that may have led to this point and their main purpose is that of ameliorating the negative effect and potentially reversing the process.

Proper nutrition is absolutely crucial for patients with Fibromyalgia. Since this syndrome can affect all the areas of one’s body, making sure that you are not making your condition any worse by eating poorly is very important.

All unhealthy foods should be eliminated from your diet. Foods containing saturated fats (such as the fast-food products), foods rich in sugar, caffeinated products and, in the case of those with gluten sensitivity, foods containing gluten – these are the most common harmful things you should replace in your diet.

What to replace them with? Fatty fish, nuts, coconut oil and olive oil, vegetables, gluten-free products – these are just some of the foods you can start incorporating into your diet. Furthermore, milk may be appropriate for you, since you will need calcium and vitamin D, but if you have lactose intolerance, dairy products can worsen your condition.

Other than proper diet, your doctor will also recommend you to take some supplements and vitamins that will help with ameliorating your symptoms. Among these, vitamin D is probably the most commonly encountered.Supplements and vitamins for fibromyalgia

Very often, patients with Fibromyalgia will experience comorbid depression and anxiety, in addition to chronic pain (the main Fibromyalgia symptom). Vitamin D deficiency has been associated with these disorders, as well as with muscle pain, so making sure that you get enough of it may help.

Another supplement a medical professional may recommend you if you are diagnosed with Fibromyalgia is fish oil. Unless you do eat a lot of fatty fish (salmon, tuna, and so on), you will most likely need the omega-3 fatty acids contained by it and you may take it from fish oil. Furthermore, this supplement has an anti-inflammatory effect, which will also be helpful with relieving pain symptoms.

Magnesium deficiency is very common in general and most of the patients with Fibromyalgia will show it as well. This mineral will basically help every single part of your body function properly, starting with your heart and ending with your kidneys.

Furthermore, muscle pain and back pain are also associated with this deficiency, and I is quite likely you will not be getting enough magnesium from food alone. Thus, taking a magnesium supplement daily can help you if you suffer from Fibromyalgia.

B vitamin deficiency is also very common and your doctor may also recommend B-complex supplements. B6 is one of those vitamins that will always help as an anti-inflammatory, and this is why patients with Fibromyalgia may be especially recommended to take it.

SAMe may be something you have not heard of before. As a matter of fact, it wasn’t until several decades ago that specialists discovered that it can be linked to certain diseases and disorders, such as osteoarthritis and depression.

Ever since then, SAMe started to be produced in the laboratory and it is now considered to be a supplement in the United States of America and a prescription drug in other parts of the world. This supplement can help with relieving chronic pain in the case of those with Fibromyalgia, but it can also be used for those with Alzheimer’s, Parkinson’s, liver diseases, dementia, ADHD, lead poisoning and many, many other medical conditions.

Whatever supplements it may be that you want to take, make sure that it was recommended by a doctor, since some of them may harm you more than do you any good. Other than that, eat healthy and maintain yourself positive!

Unlocking The Mysteries Of The Cuttlefish’s Camouflage

[ Watch the Video: What Mechanisms Are Behind Cuttlefish Camouflage? ]

Brett Smith for redOrbit.com – Your Universe Online

Capable of producing zebra-like camouflage or ‘hypnotic’ color oscillations, the skin of the cuttlefish has long fascinated scientists looking to unlock its secrets. Now, a new study from Harvard University has revealed a natural nanoscale photonic device that allows the so-called ‘chameleon of the sea’ to dynamically change its colors.

“Nature solved the riddle of adaptive camouflage a long time ago,” said study author Kevin Kit Parker, a professor of bioengineering and applied physics at the Harvard. “Now the challenge is to reverse-engineer this system in a cost-efficient, synthetic system that is amenable to mass manufacturing.”

By using pigmented organs called chromatophores, the cephalopod can change the look of its skin in response to visual stimuli. Scientists have been unable to understand the biological, chemical, and optical mechanics behind this adaptive coloration.

To change skin color, the cuttlefish uses a system of vertically arranged optical components: the leucophore, a light scatterer that spreads light evenly over the visible spectrum; the iridophore, a reflector made from thin films; and the chromatophore. This layered system allows the cuttlefish skin to selectively absorb or reflect light of different colors, the researchers said.

“Chromatophores were previously considered to be pigmentary organs that acted simply as selective color filters,” said study author Leila F. Deravi, a research associate in bioengineering at Harvard. “But our results suggest that they play a more complex role; they contain luminescent protein nanostructures that enable the cuttlefish to make quick and elaborate changes in its skin pigmentation.”

When the cuttlefish changes its skin color, each chromatophore expands – changing the surface area of each by as much as 500 percent. In the new study, which was published in the Journal of the Royal Society Interface, researchers revealed that fully-expanded chromatophore has two factors related to maintaining skin color intensity: the presence of certain proteins – reflectin and crystallin – in pigment granules and pigment layers as thin as three granules that maintain optical effectiveness – effectively functioning as nanoscale photonic elements.

“The cuttlefish uses an ingenious approach to materials composition and structure, one that we have never employed in our engineered displays,” said co-author Evelyn Hu, a professor of applied physics and of electrical engineering at Harvard.

“It is extremely challenging for us to replicate the mechanisms that the cuttlefish uses,” she added. “For example, we cannot yet engineer materials that have the elasticity to expand 500 times in surface area. And were we able to do so, the richness of color of the expanded and unexpanded material would be dramatically different – think of stretching and shrinking a balloon.”

“The cuttlefish may have found a way to compensate for this change in richness of color by being an ‘active’ light emitter (fluorescent), not simply modulating light through passive reflection,” Hu said.

By studying the cuttlefish skin, the researchers say they hope to engineer new types of military camouflage.

“Throughout history, people have dreamed of having an ‘invisible suit,'” said Parker, an Army reservist who completed two tours of duty in Afghanistan. “Nature solved that problem, and now it’s up to us to replicate this genius so, like the cuttlefish, we can avoid our predators.”

Nigella Sativa May Help Fibromyalgia

Nigella Sativa May Help Fibromyalgia

People with fibromyalgia have chronic pain that results from inflamed muscle and tissue.  Fibromyalgia causes painful and achy spots in the muscle, and can prevent people from being active.  Pain can range from mild to severe, and some people who have fibromyalgia have a hard time getting out of bed.

Aside from the chronic muscle pain, fibromyalgia can also lead to anxiety, depression, isolation, and others due to the pain endured by sufferers.

As treatment, people try various different methods including: massage, acupuncture, drug treatments, homeopathy, stress relief exercises, meditation, exercise, and others.  There are many lifestyle changes that people with fibromyalgia pain must make.

People with fibromyalgia often suffer from fatigue, and have a hard time sleeping.  Even when they first wake up, they may feel tired and not rested. Therefore, it is important for people to manage their stress levels, and to work to try to avoid depression and isolation.

There are different drug treatments used to ease the pain of fibromyalgia.  Corticosteroids and NSAIDS are treatments that can ease pain, but they can also have adverse side effects.

Many people are seeking alternative methods of healing, including homeopathic and natural/alternative medicine.  These methods use natural substances to treat conditions and diseases.

One natural method to ease fibromyalgia is taking colloidal silver (2-4 ounces per day).  Proteolytic and digestic enzymes can be taken to help dissolve fibrin.

Other natural supplements that may help include: curcumin, magnesium, Nigella sativa (blackseed oil), and herbal oleander.  All of these work with the immune system.  Nigella sativa may help fibromyalgia.

It has been estimated that 80-95% of people with fibromyalgia are magnesium deficient. Magnesium is a necessary nutrient for over 300 biochemical functions in the body.

Colloidal silver has been very effective in helping to treat fibromyalgia symptoms.  Herbal oleander is a powerful immune booster and can be helpful in relieving fibromyalgia.  This should be taken in a proven supplement form, as it can be toxic in high doses.

Vitamin D3 is am immune modulator and D3 deficiency has been linked to immune disorders. Circumin is the active ingredient in turmeric and is an immune modulator that relieves pain and inflammation.

Garlic and Echinacea strengthen the immune system and improve circulation.  Capsaicin cream uses an ingredient from peppers to relieve pain topically.

A vitamin B12 deficiency can contribute to fibromyalgia.  And people who are not sleeping well can try skullcap and valerian to assist in sleep.

Eating apples and drinking apple juice can be helpful, as apples contain malic acid, which has been shown to ease inflammation and pain.

It is also suggested to eat omega 3’s and other essential fatty acids.  Eating yogurt is also beneficial, as yogurt contains active cultures.

It is recommended to avoid sugar and artificial sweeteners, and to cut back on whole grain foods and bleached flour.

Another alternative medicine method is acupuncture.  This has been accepted by the National Institutes of Health (NIH) as a verified pain management solution.  Acupuncture is a traditional Chinese practice that involves using small needed to poke the skin, opening qi and allowing body energy to flow.

Natural foods and supplements including parsley, chlorella and cilantro are all good for helping the body remove heavy metals.

Niacin and niacinamide are also recommended supplements.  Niacinamide slows down the body’s natural detox phase, while niacin speeds up phase 2 of the body’s natural detox process.  In the first phase, the toxins are reduced to smaller fragments, and in phase 2 the fragments are bound to other molecules.  In this process, other non-toxic molecules are eliminated by urine or stool.

If someone has an overload of toxins, it can cause a problem.  This problem is believed to lead in part to fibromyalgia and to other issues such as chronic fatigue.

People with fibromyalgia should also be sure to exercise, and should try low-impact sports and activities such as cycling and swimming.  Staying active is great for muscles and joints.

All of these mentioned are alternative medicines to traditional drugs.  These treatments are safe when used in the appropriate doses, and have less interaction and adverse affects than pharmaceutical drugs.

Many people are turning to alternative medicine after years spent on pharmaceutical drugs to no avail.  These supplements are all-natural and are a great option for those who do not want to take drugs that are produced by the pharmaceutical industry.

It is important to consult a homeopathic or naturopathic doctor to discuss the proper supplements to take for fibromyalgia.  Natural treatments such as Nigella seeds and others should be strongly considered for those who want an alternative method for dealing with chronic pain from fibromyalgia.

Researchers Say ‘Caffeine Use Disorder’ Is A Major Health Concern

[ Watch the Video: Caffeine Addiction Can Cause Withdrawals ]

Brett Smith for redOrbit.com – Your Universe Online

Some people like to chalk up their regular caffeine use as a personality quirk, but a new research review has asserted that habitual use of the stimulant can actually be classified as a condition – Caffeine Use Disorder.

According to the study, published in the Journal of Caffeine Research, many people are reliant on caffeine to the point they experience withdrawal symptoms when they abstain from use and are unable to stop their caffeine intake even if they have a condition that calls for it —such as pregnancy, a heart condition, or a bleeding disorder.

“The negative effects of caffeine are often not recognized as such because it is a socially acceptable and widely consumed drug that is well integrated into our customs and routines,” said study author Laura Juliano, a psychology professor at American University. “And while many people can consume caffeine without harm, for some it produces negative effects, physical dependence, interferes with daily functioning, and can be difficult to give up, which are signs of problematic use.”

In their review, the scientists considered previously published caffeine research looking for biological proof of caffeine dependence, data that indicated how prevalent dependence is, and noteworthy physical or psychological symptoms experienced by habitual caffeine users.

The researchers concluded that healthy adults should limit caffeine usage to no greater than 400 mg per day, the same as about two to three cups of coffee. Expectant women should take in less than 200 mg per day and individuals who suffer from anxiety or insomnia as well as people who have high blood pressure, heart issues, or urinary incontinence should also reduce caffeine intake.

The team also discussed the diagnostic criteria for Caffeine Use Disorder and outline an agenda to help direct future caffeine dependence research.

“There is misconception among professionals and lay people alike that caffeine is not difficult to give up,” Juliano said. “However, in population-based studies, more than 50 percent of regular caffeine consumers report that they have had difficulty quitting or reducing caffeine use.”

The study authors noted that, for many people, limiting caffeine intake can be difficult as most people don’t actually know how much caffeine they drink daily.

“At this time, manufacturers are not required to label caffeine amounts and some products such as energy drinks do not have regulated limits on caffeine,” Juliano said, adding that people could perhaps better limit their consumption and avoid caffeine’s negative effects with better labeling.

She noted that research in the review indicated there is a demand among caffeine users to cut back on their daily habit.

“Through our research, we have observed that people who have been unable to quit or cut back on caffeine on their own would be interested in receiving formal treatment—similar to the outside assistance people can turn to if they want to quit smoking or tobacco use,” Juliano said.

Last spring, the American Psychiatric Association formally accepted Caffeine Use Disorder as a health issue in need of additional research in the Diagnostic and Statistical Manual of Mental Health Disorders – the standard reference for mental disorders.

How Fibromyalgia Affects Sleep & Mood

How Fibromyalgia Affects Sleep & Mood

Understanding fibromyalgia

In order to successfully combat any disease it is important to first understand it in its entirety before developing treatments and therapies there are actually effective. Fibromyalgia is a complex disease whose roots lie in the central nervous system.

This is a disease that is caused by the improper functioning of the pain centers and other elements of the central nervous system. The most common malfunction that is seen in patients suffering from this disease is that their central nervous systems are more active while processing pain than any other sensation.

The pain centers of a patient suffering from fibromyalgia overreact and tend to amplify any pain sensations that come in from the sensory nerves.  This can particularly be seen in neurons close to the spinal cord.

Patients who suffer from fibromyalgia commonly a report other psychological problems as well.  Most of the psychological problems can also be tight two of the improper functioning of certain elements of the central nervous system. One of the most common problems that is reported by patients suffering from fibromyalgia is depression.

It is thought that the mechanisms of the malfunctions that cause depression are similar to those that cause of chronic pain and other symptoms that are associated with fibromyalgia.

Symptoms & effects of fibromyalgia

Fibromyalgia has a variety of symptoms that show up differently in different patients. Not all symptoms of fibromyalgia may be present in one single patient. Certain patients have one set of symptoms while others have a completely different set of symptoms.

The most common symptom however, that is seen in nearly every single patient to fibromyalgia is chronic pain.  This pain can be concentrated in certain areas of the body or it can be diffuse.  Another symptom is a lack of cognitive function and the ability to concentrate on tasks.

Patients suffering from fibromyalgia tend to have difficulty in multitasking and concentrating on tasks that require undivided attention. They also have irregular and abnormal sleep patterns that further propagate their cognitive problems.

Mood swings are another symptom of fibromyalgia. One condition that has a role both as an effect and a trigger of fibromyalgia is depression. People with fibromyalgia tend to have problems with depression. This depression can arise due to the constant in chronic pain that these people experience.

Patients of this disease also experienced a heightened pain response to tactile pressure on various locations of the body. The effects of fibromyalgia are not just limited to those related to the central nervous system. One of the symptoms is irritable bowel syndrome and other kinds of gastric distress.

How sleep and mood are affected by fibromyalgia

As fibromyalgia affects the central nervous system and the way processes different sensation from different parts of the body it can cause a great deal of problems in sleep and mood regulation. One common sleep problem that is reported by people suffering from fibromyalgia is that of continuous fatigue.

These patients complain of being tired even after sleeping for long periods of time. Another problem is that of sleep interruption. Patients who suffer from fibromyalgia usually have interrupted sleep patterns during which they wake up for short periods of time and then go back to sleep.  These wakeful periods are so short that they are not remembered after waking up.

The result of this is a constant feeling of tiredness even after a long period of sleep. This is because while the patient remembers that they slept for a long period of time, they were in fact waking up for short periods which causes the brain to remain active and not going to a relaxed state. The sleep interruptions can also happen due to sleep apnea.

Another thing that contributes to regular sleep is the constant and chronic pain that comes with fibromyalgia.  Other disorders also complicate sleep such as restless legs syndrome and tremors.

Due to the disruption of sleep patterns the moods of patients suffering with fibromyalgia are also deeply affected.  Nearly all the mood problems that are associated with sleep deprivation can be seen in patients who suffer from interrupted sleep patterns due to fibromyalgia.

The constant and chronic pain can also lead to depression that further worsens the moods and mood regulation in patients of this disease.  It is important to ensure proper sleep patterns and sleep regulation in order to solve the problems associated with irregular moods caused due to fibromyalgia.  Improper sleep is also caused due to the anxiety associated with fibromyalgia.

Greenhouse Gas Reduction Program Doing Better Than Expected

Steven Siceloff – NASA’s Kennedy Space Center, Fla.

Early figures from a pilot program at Kennedy Space Center show that electric cars are reducing greenhouse gas emissions by a far greater amount than expected, according to the program’s coordinator.

“The numbers are 10 times better than we thought we’d ever see,” said Frank Kline with Kennedy’s Sustainability office. “No one’s ever done a pilot where you get actual numbers. It’s always been estimates only.”

The results are more than academic since all federal agencies are under a presidential order to reduce greenhouse gas emissions. For NASA, the goal is a 12.3 percent reduction by 2020. The executive order includes a category that judges how much gas is emitted from sources that are not controlled by the agency, including things ranging from the gases produced by an airliner carrying a NASA employee on assignment to the emissions from an employee’s car during the daily commute.

“The biggest one is federal employee commutes — that’s the easiest target to go after,” Kline said. “If we want to stop you from producing greenhouse gases, electric vehicles don’t produce any greenhouse gases.”

Even with electric cars, the reduction is not 100 percent because even though an electric car itself produces no emissions, the power plant that made the electricity produced greenhouse gases in the process.

“The average car puts out about a pound of carbon dioxide per mile,” Kline said. “We’re reducing that by 3/5ths by letting you plug in at the Kennedy Space Center.”

The program is working with 10 Kennedy workers who commute daily and plug in their cars at the center’s charging stations. In return for receiving free charging, each of the workers fills out a spreadsheet each day documenting how many miles were driven and the road and traffic conditions.

“What we’re trying to capture is fully electric plug-ins,” Kline said. “The hybrid is not that different from gasoline-powered cars. It’s better, but if you go electric, that’s really where you see the bang for the buck. Fully electric is where we want to be.”

Calculations made from that information is showing a dramatic reduction in the amount of emissions from the daily commute.

“The numbers are really insane,” Kline said. “The program’s first three months only cost $148, and we eliminated over 15,000 pounds of carbon dioxide into the atmosphere. Over a whole year, we’ll save over 60,000 pounds and that’s just with 10 drivers.”

Considering the center employs some 8,000 people, the potential to significantly alter the amount of emissions from daily commutes by installing even a modest network of outlets is compelling, Kline said, and not very expensive.

“If you just put some infrastructure in and get people to plug in, you can do more to reduce carbon dioxide and you won’t have to spend multi-million dollars,” Kline said.

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Obesity In Women Could Be Prevented With Certain Probiotics: Study

redOrbit Staff & Wire Reports – Your Universe Online

Certain types of probiotics could help women combat obesity by restoring the balance of their intestinal microbiota in favor of bacteria that helps promote healthy weight, according to new research recently published in the British Journal of Nutrition.

While previous studies have demonstrated that obese men and women have a different intestinal flora than those of their fitter counterparts, the study authors set out to determine whether or not consuming probiotics could have a positive impact on those gut-based microorganisms, they explained in a statement Tuesday.

Dr. Angelo Tremblay, of Université Laval, and colleagues tested their hypothesis by recruiting 125 overweight individuals. Those individuals then took part in a 12-week weight-loss diet, followed by a 12-week period designed to maintain body weight.

Half of the study group were given two daily pills containing probiotics from the Lactobacillus rhamnosus family, while the other half received a placebo. Following the 12-week diet period, women who received probiotics lost more weight 9.7 lbs. on average — than those who were given placebos — 5.7 lbs.

However, no such effect was observed in men, according to Dr. Tremblay, who also serves as the Canada Research Chair in Environment and Energy Balance. “We don’t know why the probiotics didn’t have any effect on men,” he said. “It may be a question of dosage, or the study period may have been too short.”

At the conclusion of the 12-week maintenance period, the weight of the women in the placebo group remained stable. However, those in the probiotic group continued to lose weight, raising the total to an average of 11.46 lbs. per person, the researchers said. All told, the women taking probiotics lost twice as much weight over the course of the study.

Dr. Tremblay’s team also observed a decrease in the appetite-regulating hormone leptin and a lower overall concentration in obesity-related intestinal bacteria in this group. They believe that the probiotics could be altering the permeability of the intestinal wall, preventing some types of proinflammatory molecules from reaching the bloodstream and ultimately helping to prevent glucose intolerance, Type 2 diabetes, and obesity.

While the L. rhamnosus strain involved in the study is used by yogurts made by Nestle in Europe, the investigators believe that probiotics found in North American dairy products could have a similar impact. However, they emphasize that the benefits of these microorganisms “are more likely to be observed in a favorable nutritional context that promotes low fat and adequate fiber intake,” the university explained.

Melatonin Therapy May Help Slow Breast Cancer Tumor Growth

Brett Smith for redOrbit.com – Your Universe Online

Produced by the brain in response to darkness and often taken as a sleep aid supplement, melatonin could be effective in slowing the growth of certain breast cancer tumors, according to a new report published in the open-access journal PLOS ONE.

More specifically, melatonin may stunt tumor growth and tumor cell production, as well as obstruct the generation of new blood vessels in breast cancer cells that test negative for estrogen receptors, referred to as ER-negative.

“These early stage research results with the melatonin drug in a triple-negative breast cancer animal models achieved in our lab has not been seen anywhere else,” said study author Adarsh Shankar, a radiology researcher at Henry Ford Hospital in Detroit. “The key finding of the study is that we now know that we can trace this drug and its effect on tumor growth, which opens the door for more research on this topic.”

A promising approach in reducing cancer progression is finding a way to mitigate angiogenesis, the tumor’s development of new arteries. Once a tumor exceeds several millimeters in diameter, a lack of oxygen triggers a series of events that enable angiogenesis and tumor growth.

To determine the effectiveness of melatonin on tumor expansion, the international team of study researchers evaluated the action of the naturally produced substance on angiogenesis in ER-negative breast cancer using both in vitro and in vivo using cell and mouse models respectively.

The mice were randomly assigned to either melatonin or control groups. The melatonin group was treated every night for 21 days. Melatonin was administered at a pharmacologic dose one hour before the lights in lab were turned off. Melatonin is thought to be more effective before sleep because tissues are most sensitive to the hormone at this time.

At the end of the 21-day regimen, scientists used single photon emission computed tomography (SPECT) to establish whether melatonin therapy properly decreased the size of human triple negative breast cancer in the rodents and if there was any modifications in the development of new blood vessels. The researchers also measured tumor volume each week. Tumor tissue was analyzed at the end of the 21-day period.

The study said none of the treated mice showed any loss of weight or energy during the 21-day treatment — in fact, most showed excessive movement, yet no irritability or hostile behavior.

Those treated showed considerably smaller tumors after 21 days while the mean tumor volume heightened noticeably in the control group. The researcher also found less vascular growth in the tumors of the treated group.

The study team said they found similar results in their cellular models.

The scientists called for more research on this potential treatment – particularly on how melatonin affects angiogenesis in various cancers – before human trials can be carried out.

In another study investigating the link between cancer and sleep, a team of American researchers found that disrupted sleep patterns can accelerate the progression of cancer.

Are Stem Cells The Cure To Baldness?

[ Watch the Video: Bald Men May One Day Get Help From Stem Cells ]

Brett Smith for redOrbit.com – Your Universe Online

While a Chinese cream may not have cured George Costanza’s baldness in a classic Seinfeld episode, stem cell research from scientists at the University of Pennsylvania has shown the potential for regenerating hair follicles – which could lead to relief for hair-challenged men everywhere.

According to a new report published in the journal Nature Communications, the Pennsylvania researchers have developed a groundbreaking method for converting adult cells into epithelial stem cells (EpSCs). Similar previous efforts have failed to generate an adequate number of hair-follicle-generating stem cells.

In the study, epithelial stem cells were inserted into immunocompromised mice. The stem cells regenerated the various cell types for human skin and hair follicles, and provided structurally identifiable hair shafts, raising the possibility of hair regeneration in humans.

The study team began with human skin cells referred to as dermal fibroblasts. By incorporating three genes, they modified those cells into induced pluripotent stem cells (iPSCs), which have the capacity to differentiate into any cell types in the human body. Next, they modified the iPS cells into epithelial stem cells, commonly located at the base of hair follicles.

Starting with procedures other research groups had worked out to transfer iPSCs into skin cells, Xu’s team figured out that by carefully manipulating the timing of the cell growth factors, they could drive the iPSCs to produce large quantities of epithelial stem cells. This method was able to turn more than 25 percent of the iPSCs into epithelial stem cells within 18 days. Those cells were then purified based on the proteins they showed on their surfaces.

Comparison of the engineered cells with epithelial stem tissue obtained from hair follicles revealed the team succeeded in making the cells they set out to produce. After mixing all those cells with mouse follicular inductive dermal cells and attaching them onto the pores and skin of immunodeficient mice, the team was able to produce efficient outer layers of human skin tissue and follicles structurally similar to those generated by human hair.

“This is the first time anyone has made scalable amounts of epithelial stem cells that are capable of generating the epithelial component of hair follicles,” said study author Dr. Xiaowei “George” Xu, associate professor of pathology and laboratory medicine and dermatology at the university. He added that these cells could be used for healing, cosmetics and hair regeneration.

Xu cautioned that iPSC-derived epithelial stem cells are not yet ready for human subjects.

“When a person loses hair, they lose (two) types of cells.” Xu said. “We have solved one major problem, the epithelial component of the hair follicle. We need to figure out a way to also make new dermal papillae cells, and no one has figured that part out yet.”

Dermal papillae are small extensions of the dermis into the epidermis. They appear as ridges on the skin and are most commonly known as the ridges that make up fingerprints.

Xu also noted that the process his team used to create iPSCs involves genetic alterations to human cells with genes encoding proteins linked to cancer, and therefore needs refinement. He said stem-cell researchers are currently working on solutions, including methods using only chemical agents.

Making Music Videos Helps Young Cancer Patients Cope With Treatment

Ranjini Raghunath for redOrbit.com – Your Universe Online

Cancer treatment – through chemotherapy, radiation or stem cell therapies – can be physically and mentally exhausting for patients, especially younger ones. Many factors can help them feel positive about themselves and their treatment, including spiritual practices, supportive home environments and strong social connections with friends, family and physicians.

Now, a new study shows that making music videos and writing song lyrics may also help young cancer patients better cope with their treatment.

Researchers at the Indiana University School of Nursing, Indianapolis, carried out the music therapy intervention study, which was published online in the journal Cancer.

113 young patients aged 11-24 undergoing stem cell transplants for cancer were selected randomly for the study. Half of them were given audiobooks (the control group) and the other half were given three weeks to write down song lyrics, collect images and record music videos.

Patients in the second (test) group went through six “training” sessions each with a music therapist, who helped them identify and write about what was important to them, and guided them in creating the videos.

“It really targeted them writing, having an opportunity to write about what’s important to them,” co-author of the study and music therapist, Sheri Robb, told Reuters. “A lot of these kids as they’re going through treatment, they tend to not talk about these things.”

The patients also had a chance to share the videos they created with family and friends. After about 100 days of treatment, patients in the test group reported that making those videos helped them better connect with their loved ones.

The intervention therapy helped the young patients feel stronger, more positive and helped improve their relationships with family and physicians, based on their responses to follow-up questionnaires, the researchers reported.

The patients’ parents also found the videos to be very helpful in understanding the experiences their children were going through during their treatment, the researchers found.

“The availability of music therapy services from a board-certified music therapist in the United States has become more widespread, and through studies like this one, we hope to see increased availability and access to this important allied health service,” Robb said in a statement. “One of the challenges in healthcare today is making sure that research findings from studies such as ours are used to inform healthcare practices and service delivery.”

The research team plans to carry out further studies to test the potential benefits of including parents in the intervention, and how best to integrate such therapy into standard care for cancer patients.

Exercise Found To Reduce Risk Of Cancer-Related Deaths In Men

redOrbit Staff & Wire Reports – Your Universe Online

Regular physical activity could reduce the risk of death in male cancer patients by nearly half, according to research appearing in the latest edition of the Journal of Physical Activity & Health.

As part of the study, researchers from the Loyola University Chicago Stritch School of Medicine and Harvard Medical School looked at data from 1,021 men with an average age of 71. Each of the men had previously been diagnosed with cancer, and completed questionnaires on their exercise habits in 1988, 1993 and 2008.

According to the Huffington Post, men that burned at least 12,600 calories each week reduced fatality risk by 48 percent over a 15-year period compared to those who burned less than 2,100 calories weekly.

Those who exercised most also had a 49 percent decreased risk of cardiovascular disease-related deaths, and were 38-percent less likely to die from cancer-related causes, Medical Express reported on Friday.

The physical activities reported included walking, stair-climbing and participation in sports and similar recreational activities. The findings were adjusted for age, body mass index (BMI), dietary variables, early parental mortality and smoking habits and involved men who enrolled in the Harvard Alumni Health Study between 1916 and 1950.

“Physical activity should be actively promoted to such individuals to enhance longevity,” study co-author Dr. Kathleen Y. Wolin of the Loyola University Chicago Stritch School of Medicine said, according to Sarah Griffiths of the Daily Mail.

“The research supports a previous study that found the most physically active cancer survivors are much less likely to die of cancer and heart disease,” Griffiths added. “While there has been plenty of research that shows regular exercise boosts the life expectancy of healthy people, this study is among very few that show exercise also extended the life of cancer survivors.”

The research conducted by Dr. Wolin and her colleagues was a prospective cohort study, and during the 15-year period, 777 of the men died (337 from cancer and 190 from cardiovascular disease). I-Min Lee, Sarah E. Freeman, Jacob Sattelmair, and Howard D. Sesso were also credited as authors of the paper.

The new study, which looked at cancers other than nonmelanoma skin cancer, is the latest in a long line of studies showing that exercise can help prevent cancer or cancer-related deaths.

Earlier this month, medical experts identified the reasons behind the association between walking and prostate cancer outcomes, while in October 2013, regular physical activity was found to significantly reduce the risk of breast cancer in postmenopausal women.

Interstellar Dust Particles Carry Water, Organic Compounds To Earth

[ Watch the Video: What Could Be Raining Down Life In Our Solar System? ]
redOrbit Staff & Wire Reports – Your Universe Online
Dust that originates from comets, asteroids and leftover debris from the birth of the Solar System could deliver water and organic material to the Earth and other terrestrial planets, according to a recent Proceedings of the National Academy of Science paper.
In the study, researchers from the University of Hawaii-Manoa (UHM) School of Ocean and Earth Science and Technology (SOEST), the Lawrence Livermore National Laboratory (LLNL), the Lawrence Berkeley National Laboratory and the University of California-Berkeley explain that these interplanetary dust particles (IDPs) continually rain down upon our planet and other worlds in our Solar System.
The IDPs are bombarded by solar wind, especially hydrogen ions, and these ions disturb the order of the atoms in the silicate mineral crystal. This process leaves behind oxygen, which is more readily available to react with hydrogen in order to create water molecules, the study authors explained in a statement Friday.
“It is a thrilling possibility that this influx of dust has acted as a continuous rainfall of little reaction vessels containing both the water and organics needed for the eventual origin of life on Earth and possibly Mars,” said study co-author and UHM SOEST Hawaii Institute of Geophysics and Planetology (HIGP) associate researcher Hope Ishii.
“This mechanism of delivering both water and organics simultaneously would also work for exoplanets, worlds that orbit other stars. These raw ingredients of dust and hydrogen ions from their parent star would allow the process to happen in almost any planetary system,” the university added. “Implications of this work are potentially huge.”
For example, airless bodies such as the Moon and asteroids, with abundant amounts of silicate minerals, are being exposed to solar wind irradiation constantly. This mechanism could generate water, and would help explain remotely sensed Moon data that detected OH and preliminary water, the researchers said. Furthermore, it might help explain what caused water ice to form in the permanently shadowed areas of the lunar surface.
“Perhaps more exciting,” Ishii said, “interplanetary dust, especially dust from primitive asteroids and comets, has long been known to carry organic carbon species that survive entering the Earth’s atmosphere, and we have now demonstrated that it also carries solar-wind-generated water. So we have shown for the first time that water and organics can be delivered together.”
“It has been known since the Apollo-era, when astronauts brought back rocks and soil from the Moon, that solar wind causes the chemical makeup of the dust’s surface layer to change,” the university added. “Hence, the idea that solar wind irradiation might produce water-species has been around since then, but whether it actually does produce water has been debated.”
The reasons for the uncertainty is that only small quantities of water are produced, and only in specific areas (thin surface rims of silicate minerals). As such, older analytical techniques were unable to confirm the presence of water, but scientists have actually managed to use a state-of-the-art transmission electron microscope to detect water produced by solar-wind irradiation in the space-weathered rims on silicate minerals in IDPs.
Furthermore, on laboratory-irradiated mineral bases with similar amorphous rims, Ishii and her colleagues were able to determine that water forms from the interaction between solar wind hydrogen ions (H+) and oxygen in the silicate mineral grains. However, they do not know how much water may have been delivered to Earth using this method.
“In no way do we suggest that it was sufficient to form oceans, for example,” Ishii said. “However, the relevance of our work is not the origin of the Earth’s oceans but that we have shown continuous, co-delivery of water and organics intimately intermixed.”
“In future work, the scientists will attempt to estimate water abundances delivered to Earth by IDPs,” the university added. “Further, they will explore in more detail what other organic (carbon-based) and inorganic species are present in the water in the vesicles in interplanetary dust rims.”

Engineers Create Flexible Battery That Runs On Organ Movement

[ Watch the Video: An Organic Solution To Battery Power ]

Ranjini Raghunath for redOrbit.com – Your Universe Online

A tiny, patch-like battery that uses the natural movement of organs such as the heart or lungs to generate electricity inside the human body has been developed by engineers at the University of Illinois at Urbana-Champaign.

A paper describing the device was recently published online in the journal Proceedings of National Academy of Sciences.

The device, about the size of a stamp, is made up of a metal nanoribbon embedded in ultra-thin, flexible plastic material that’s “almost like Saran Wrap,” lead author and University of Illinois material scientist John Rogers told Popular Mechanics. “It can cling to the surface of an organ.”

Many artificial devices – pacemakers for treating irregular heartbeats or nerve stimulators for treating Parkinson’s, for instance – use batteries that run out after a few years. The new invention could one day take over for such batteries and save patients the repetitive, painful and expensive surgeries needed to replace their expired batteries.

The device works on the principle of piezoelectricity, where a metal or metal composite – lead zirconate titanate, in this case – generates electricity under mechanical stress. The device can generate up to 8 volts of electricity as it bends and stretches with the movement of the heart, lungs or diaphragm it is implanted upon.

It can generate more electricity than needed by conventional implants, the authors wrote. Its flexible design also ensures that it harvests power from the organ without hampering or adding strain to the organ’s movements.

The Illinois team, along with doctors at the University of Arizona, surgically implanted the device onto the organs of live sheep, cows and pigs. Their most recent prototypes were able to generate three to five times more electricity than previous trials in living animals.

“In addition to uses on internal organs, the same types of systems can be implemented in skin-mounted configurations for health/wellness monitors or non-biomedical devices,” the authors wrote.

The device could also be used one day to harvest energy from arm or leg muscles, or skin cells, or “pretty much anything that moves,” Rogers said.

Although the device prototypes have been tested for their capacity for only a few hours, Rogers’ team is working on testing and checking their electric output over longer time periods. They are also working on additional tests to make sure it is safe and compatible for long-term use inside the human body.

The challenge would be to make the batteries last longer than the lifetime of current pacemaker batteries, which can last for 5 to 10 years without needing to be replaced.

Rogers’ previous work includes a similar “tattoo” patch to monitor patients’ heart and brain activity, and the world’s first flexible lithium-ion battery.

Stephen Hawking Challenges Conventional Thinking On Black Holes

redOrbit Staff & Wire Reports – Your Universe Online
If most physicists claimed that the popular notion of black holes as event horizons from which light cannot escape is wrong, they would be almost immediately dismissed (and possibly even scoffed at). However, when Stephen Hawking makes such an assertion, the scientific community stands up and takes notice.
Hawking, the well-known University of Cambridge physicist who was one of the developers of modern black hole theory, has published a new paper in which he says there is no invisible firewall surrounding these black holes, and that matter and energy are only temporarily constrained before they are eventually released in an altered form.
As the professor told Nature‘s Zeeya Merali on Friday, there is “no escape from a black hole in classical theory,” but quantum theory makes it possible for “energy and information to escape from a black hole.” However, a full explanation of the process would require a theory that merges gravity with other fundamental natural forces, which physicists have been unable to find.
According to Mark Prigg of the Daily Mail, the theory advanced by Hawking in his new study is known as the “grey hole theory” and has not yet passed the peer-review process. It is based on a discussion he conducted via Skype during a meeting of the California-based Kavli Institute for Theoretical Physics last August.
Merali refers to the paper as an attempt to solve what is known as the “black hole firewall paradox,” an issue which has been puzzling theoretical physicists for nearly two years. During a thought experiment, researchers at the Kavli Institute asked what would become of an astronaut that fell into a black hole.
“Event horizons are mathematically simple consequences of Einstein’s general theory of relativity that were first pointed out by German physicist Karl Schwarzschild in 1916,” Merali explained. “In that picture, physicists had long assumed, the astronaut would happily pass through the event horizon, unaware of his or her impending doom, before gradually being pulled inwards – stretched out along the way, like spaghetti – and eventually crushed at the ‘singularity’, the black hole’s hypothetical infinitely dense core.”
However, after conducting a detailed analysis of the problem, the Kavli Institute investigators realized that the laws of quantum mechanics governing particles on a smaller scale changed the situation entirely. They claimed quantum theory would dictate that the event horizon would have to be transformed into a “firewall” – an extremely energetic region that would cause the astronaut to burn up completely.
“This was alarming because, while the firewall obeyed quantum rules, it flouted Einstein’s general theory of relativity,” Merali said. “According to that theory, someone in free fall should perceive the laws of physics as being identical everywhere in the Universe – whether they are falling into a black hole or floating in empty intergalactic space. As far as Einstein is concerned, the event horizon should be an unremarkable place.”
Hawking’s new theory takes another approach to the issue. He suggests both quantum mechanics and general relativity remain unchanged, only black holes do not actually have an event horizon to catch fire. Merali explained that this notion is based on the fact that quantum effects surrounding the black hole would cause too many unpredictable spacetime fluctuations around the phenomenon for this kind of boundary surface to exist.
Instead, Hawking suggests that there is an “apparent horizon” around the black holes, and that this surface suspends light rays attempting to flee its core. In terms of general relativity, both types of horizons are identical in an unchanging black hole, because light attempting to escape from the inside would only be able to reach the black hole before it is held there. However, in principle, both horizons can be distinguished from one another. If the black hole swallows more matter, its event horizon would swell and grow larger than the apparent horizon.
As SmithsonianMag.com’s Colin Schultz explains it, Hawking says that while there is “something like a black hole… out there,” their grip “is not quite so enduring or destructive as we thought.” Basically, he “wants to do away with the idea of the black hole’s iconic ‘event horizon’ and turn this ultimate gravitational cliff into something a little less steep.”
Former Hawking student and University of California, Berkeley theoretical physicist Raphael Bousso told Prigg that many physicists may find Hawking’s newest work “abhorrent.” However, he added, “the fact that we’re still discussing such questions 40 years after Hawking’s first papers on black holes and information is testament to their enormous significance.”

Food Addiction Linked To Impulsive Personality In Some Cases

April Flowers for redOrbit.com – Your Universe Online

New research from the University of Georgia (UGA), published in the journal Appetite, reveals that the same kinds of impulsive behavior that leads some individuals to abuse alcohol and drugs may also contribute to an unhealthy relationship with food.

The research team found that people with impulsive personalities were more likely to report higher levels of food addiction, which can lead to obesity. Food addiction is a compulsive pattern of eating that is similar to drug addiction.

“The notion of food addiction is a very new one, and one that has generated a lot of interest,” James MacKillop, associate professor of psychology at the Franklin College of Arts and Sciences, told UGA’s James Hataway. “My lab generally studies alcohol, nicotine and other forms of drug addiction, but we think it’s possible to think about impulsivity, food addiction and obesity using some of the same techniques.”

According to the Centers for Disease Control and Prevention (CDC), more than one-third of American adults are obese. This puts them at greater risk for heart disease, stroke, type 2 diabetes and certain types of cancer. Researchers estimated the annual medical cost of obesity to be $147 billion in 2008, while obese individuals pay, on average, $1,429 more in medical expenses than those of normal weight.

MacKillop collaborated with doctoral students Cara Murphy and Monika Stojek on this study. The team hopes that their research will ultimately help physicians and other experts plan treatments and interventions for obese people who have developed an addiction to food, paving the way for a healthier lifestyle.

Two different scales were used to determine levels of food addition and impulsivity among the 223 study participants—the Yale Food Addiction Scale and the UPPS-P Impulsive Behavior Scale. The results of these scales were compared with the participant’s body mass index (BMI), which is used to determine obesity.

“Our study shows that impulsive behavior was not necessarily associated with obesity, but impulsive behaviors can lead to food addiction,” MacKillop said.

Not everyone who exhibits impulsive behavior will become obese. However, an increase in certain impulsive behaviors is linked to food addiction, the study shows, which appeared to be the driving force behind higher BMI in study participants.

The findings of the study are amongst the first to examine addictive eating habits and how they contribute to obesity. MacKillop’s team plans to expand their research by analyzing brain activity of different individuals as they make decisions about food.

Currently, the food industry has created a wide variety of eating options. MacKillop says that foods high in fat, sodium, sugar and other flavorful additives appear to produce cravings much like illicit drugs. The team wants to understand how those intense cravings might play a role in the development of obesity.

“Modern neuroscience has helped us understand how substances like drugs and alcohol co-opt areas of the brain that evolved to release dopamine and create a sense of happiness or satisfaction,” he said. “And now we realize that certain types of food also hijack these brain circuits and lay the foundation for compulsive eating habits that are similar to drug addiction.”

Researchers Find No Significant Health Benefits From Vitamin D Supplements

redOrbit Staff & Wire Reports – Your Universe Online
Healthy people taking vitamin D supplements are unlikely to see any significant impact when it comes to preventing broken bones or cardiovascular conditions, claims new research appearing in the latest edition of The Lancet Diabetes & Endocrinology.
According to the AFP news agency, the study authors reviewed more than 40 previous trials in order to determine whether or not use of these vitamin supplements achieved a benchmark of reducing the risk of heart attacks, strokes, cancer or bone fractures by at least 15 percent.
“Previous research had seen a strong link between vitamin D deficiency and poor health in these areas,” the news agency said. However, the new study “strengthens arguments that vitamin D deficiency is usually the result of ill health – not the cause of it,” and the authors report that “there is ‘little justification’ for doctors to prescribe vitamin D supplements as a preventive measure for these disorders.”
All told, the investigators reported that the use of vitamin D supplements failed to significantly reduce a person’s risk of death, heart disease, cancer or stroke among the study participants. Likewise, in both healthy and hospitalized men and women, it also failed to result in a noticeable reduction of hip fracture risk, according to FoxNews.com.
In their study, the researchers reviewed randomized controlled trials of vitamin D supplement use both with and without calcium, BBC News explained. The research was led by University of Auckland senior research fellow Dr. Mark Bolland and funded by the Health Research Council of New Zealand.
“Previous research has shown that vitamin D deficiency is associated with poor health and early death,” but the new evidence suggests that “that low levels of vitamin D are a result, not a cause, of poor health,” HealthDay News explained. Likewise, in an editorial accompanying the paper, one university professor said that there is legitimate concern that using the supplements could cause harm in healthy men and women.
“The impression that vitamin D is a sunshine vitamin and that increasing doses lead to improved health is far from clear,” Karl Michaelsson of the department of surgical sciences at Uppsala University, told BBC News. He urged caution when it came to taking vitamin D supplements until scientists can glean more information about the effect of doing so.

How A South American Tree Adapts To Volcanic Soils

American Journal of Botany
Low soil nitrogen, not soil phosphorus levels, stimulate cluster root adaptation in the Proteaceae, Embothrium coccineum, a tree that may be key to reforestation in Patagonia
Soils of southern South America, including Patagonia, have endured a high frequency of disturbances from volcanic eruptions, earthquakes, landslides, and erosion. In addition, massive fires in the mid-20th century were set to forests in the region in an effort to promote colonization. In 2010, another 17,000 acres of Patagonia burned, fueling an international reforestation effort. Although the young soils of southern South America may contain high phosphorus levels, the element is tightly bound to the soil, offering limited phosphorus available to plants.
So how can plants in this area take root and access that phosphorus?
According to a recent article published in the American Journal of Botany, scientists have identified a mechanism enabling a native tree species access to this limiting nutrient. As a result, the Chilean fire bush (Proteaceae, Embothrium coccineum), a tree endemic to Chile and Argentina, could have an important role in the reforestation of Patagonia. In the wild, E. coccineum colonizes highly disturbed land where other tree species rarely occur. Proteaceae species, common in the southern hemisphere, are known for a root structure adaptation that increases phosphorus acquisition from weathered, phosphorus-poor soils. The greater surface area of cluster roots increases root exudates of organic acids and phosphatases. These exudates enhance plant phosphorus acquisition from unavailable forms in the soil.
“I was particularly curious of the ecological role of this root adaptation,” explained Frida Piper, a terrestrial ecosystem ecologist at the remote research center Centro de Investigación en Ecosistemas de la Patagonia (CIEP) in Coyhaique, Chile. Piper designed a field study to better understand the role of cluster roots of E. coccineum across a natural precipitation and phosphorus gradient in its native habitat. How does the production of cluster roots in this Proteaceae enable successful establishment in young volcanic soils of South America?
Small and large E. coccineum seedlings and topsoil were collected at four sites in the Aysén Region of Patagonia, Chile, in 2010-2013. Seedlings were assessed for number and biomass of cluster roots, plant size and growth, and foliar phosphorus levels. Soil samples were analyzed for pH, total nitrogen (N), available phosphorus (P) and organic matter. Based on biomass and chemical analyses, four dominant factors were identified: soil P, soil N, foliar P, and seedling age. A suite of generalized linear mixed–effect model regressions were fitted to the data.
In contrast to previous studies of Proteaceae in Australia and South Africa, the best-fit model for predicting the number of cluster roots in this study did not contain any soil P factor; foliar P levels correlated with cluster root formation. The number of cluster roots was significantly higher in large seedlings, yet biomass investment in cluster roots was greater for small seedlings.
Piper found that cluster roots mediate a decoupling of foliar P from soil P concentrations for small seedlings. This enabled small seedlings to maintain adequate foliar P levels, critical to their ontogenetic growth. The relative investment in cluster roots was directly linked to both low soil N and leaf P. Seedlings from sites with lower total soil N had more cluster roots, regardless of other soil characteristics. The cluster root adaptation is very sensitive and highly expressed at low total soil N levels but rapidly disappears as soil N levels increase. The investment in cluster roots declines after seedling establishment, most likely as aerial growth is increasingly important for light competition.
Embothrium coccineum may have an important role in reforestation of Patagonia as an early successional species. Cluster roots have been identified in other plant species, including some agronomic crops in the Cucurbitaceae. “The biotechnology potential of these traits is being studied now,” Piper says. Piper’s research clarifying the mechanism of seedling establishment success for E. coccineum in conditions with limited availability of N and P may lead to advantageous root adaptation in other plants.
Piper is already exploring further research to understand how E. coccineum benefits neighbors by providing increased nutrient availability from root exudates or leaf litter decomposition. As a result of this study, nitrogen status of soil and plants, in addition to phosphorus, will always be included in Proteaceae studies by Piper. “Proteaceae can do something no other plant can do,” Piper explains. “They are accessing nutrients that no other plants can access.”

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Unexpected Optical Mechanism Behind Insulating Power Of Polar Bear Fur

[ Watch the Video: Looking To Polar Bears For Insulation Tips ]

Brett Smith for redOrbit.com – Your Universe Online

In work which has major connotations for enhancing the performance of artificial insulation, a team of international researchers has determined hairs and feathers that reflect infrared light might contribute considerable insulating capacity to the remarkably warm winter coats of polar bears and other Arctic animals.

Published by the journal Optics Express, the study was partially motivated by observations of polar bears to maintaining their bodies at temperatures over 98 degrees F, even during very long, cold winter months when outdoor temperatures can reach a frigid -40 degrees F, particularly impressive provided that the bears have a covering of hair that is only 2 inches thick.)

“Why do we need to have at least 60 cm of rockwool or glasswool to obtain a temperature of (68 degrees F) inside from about (23 degrees F) outdoors?” asked study author Priscilla Simonis, a researcher at the University of Namur. “Why is the polar bear hair much more successful than what we could develop for the housing?”

The study team looked at how heat moves thermal energy via electromagnetic waves, also referred to as radiation. Additionally, they considered how thermal energy is moved via the vibrations of nearby molecules and atoms – a principle known as conduction. While feathers and fur keep animals warm by trapping a layer of warm air below, the study team suspected that radiation might play a bigger role. The scientists performed some initial calculations that showed heat loss between two bodies separated by air would be mostly by radiation, not conduction.

To further explore the heat loss from radiation, the team created a simple computer model consisting of a hot and a cold thermostat that roughly simulated an animal’s warm body and the outside, colder environment. The two thermostats were separated by an empty space into which were added “radiative shields” that could mimic the individual hairs in a fur coat.

In one edition of the model, the researchers incorporated so-called black-body shields, which absorb all of the radiation that strikes them. In a second version, solid grey-body shields were used.

“A grey body has some reflection and transmission as well,” Simonis said.

The researchers established that as the reflectivity of the radiative shields increased, the rate of heat transfer between the hot and cold thermostat was markedly lowered. Inserting more shields also significantly reduced the energy loss. The model indicated that the continued backscattering of infrared light between the shields, acting like individual hairs and feathers, could be the chief mechanism for the thermal insulation advantage of fur and feathers.

The light scattering features of animals’ coats also have another purpose, Simonis said. These coats can generate capable thermal insulation in the far infrared range while also giving a white appearance in the visible wavelength range.

“This is particularly useful to animals, such as mammals and birds, that live in snowy areas,” Simonis said, noting that the bears’ fur provides both warmth and camouflage against the white snow.

For our purposes, looking at ways to reduce radiative heat loss could lead to new types of insulation.

“The idea is to multiply the interaction of electromagnetic waves with grey bodies – reflecting bodies, like metals, with very low emissivity and no transparency – in a very thin material,” Simonis said. “It can be done by either a multilayer or a kind of ‘fur’ optimized for that purpose.”

Opportunity Rover’s 10th Anniversary Honored By Ray Arvidson

[ Watch The Video: Celebrating the Opportunity Rover’s 10th Anniversary ]

Washington University in St. Louis

Whirlwind tour of the past 10 years of adventures and discoveries by mission scientist Ray Arvidson

Ten years ago, on Jan. 24, 2004, the Opportunity rover landed on a flat plain in the southern highlands of the planet Mars and rolled into an impact crater scientists didn’t even know existed. The mission team, understandable giddy that it hadn’t crashed or mysteriously gone silent during the descent (as other Mars missions have done) called it “a hole in one.”

In honor of the rover’s 10th anniversary, Ray Arvidson, PhD, deputy principal investigator of the dual-rover mission, recently took an audience at Washington University in St. Louis on a whirlwind tour of the past decade’s exploration of Mars, cheered on by students holding signs reading “Boffins.” (“Boffin” is British slang for “scientist.”)

Introducing Arvidson, Bill McKinnon, PhD, a fellow WUSTL planetary scientist, said Arvidson had done graduate work under Tim Mutch of Brown University, who led the Lander Imaging Team for the Viking mission to Mars. When Mutch stepped down as team leader in 1977, Arvidson took over for him. Arvidson, the James S. McDonnelll Distinguished University Professor in Arts & Sciences, has been involved in every significant US interplanetary mission to Mars and Venus since then, McKinnon said.

Arvidson had a good story to tell. The 10-year-old rover, dirty and arthritic though it may be, just found evidence of conditions that would support the chemistry of life in the planet’s past, work that earned it a spot in the Jan. 24 issue of Science magazine, just in time for Opportunity’s anniversary.

Why are we on Mars?

“We’re exploring Mars to better understand Earth,” Arvidson said. “On Mars, we can learn about geological processes and environmental processes — maybe habitability, maybe life, that remains to be seen — for a period of time that’s lost on Earth.

“Mars preserves the whole geologic record,” he said, “because there’s so little erosion there. We have the whole stratigraphic section; minerals are well preserved. So by touring and exploring Mars, we can travel back into early geologic time.

“The punch line is that the farther back we look in the rock record, the more we find evidence of the interaction of relatively mild waters with the Martian crust. And the farther back we look, the better the chemical conditions for life.

“Today, Mars is dry and cold. But in the past, there were exploding volcanoes with hydrothermal vents, there were fumaroles (steam-charged vents), there were rivers, there were dendritic streams, there were lakes.

“The older you look, the better it gets in terms of warm and wet,” Arvidson said.

The MER rovers

“The rovers are really field geologists,” Arvidson said. “They’re robotically driven, but they’re doing what we would be doing if we had boots on Mars with rock hammers, collection bags, microscopes and little huts where we could do some chemical analyses.

“What people don’t realize is that on any given day, in the afternoon Mars time, when the data come down through the Deep Space Net, we get just 100 to 200 megabits. That’s a soda straw, not a fire hose. So we have to be really careful about what we command and prioritize what we acquire.

“But operating at 100 to 200 megabits per sol, we’ve attempted to reconstruct the past environment from the geologic record just as a field geologist would do. (Sols, or Martian days, are 39 minutes longer than Earth days.)

“We lost Spirit, Opportunity’s twin, back in 2010,” Arvidson said. Stuck in the sand, it was unable to point its solar arrays in the correct direction to survive winter, and it went quiet March 22, 2010, or sol 2,210.

But Arvidson is not complaining; the rovers were expected to survive only about 90 to 180 sols. “They were supposed to last three or six months and it’s been 10 years,” he said. “They were supposed to drive maybe a thousand meters, and Opportunity is now about to break 40,000 meters.”

Crater-hopping on Mars

Early in its mission although already past its expiry date (on sol 134), Opportunity drove into a 430-foot-wide crater named Endurance. It spent the next half-year exploring sedimentary layers exposed in the crater wall.

They were named the Burns formation for Roger Burns, a geologist who predicted the importance of sulfate mineralogy on Mars based on results obtained by the Viking missions and his laboratory analyses. “The formation consists of many thin layers of sulfate sandstone that formed in ancient lakebeds, were reworked into sand dunes by the wind, and then recemented into rock by rising groundwater,” Arvidson said.

Looking at the chemistry of the rocks, the mission scientists inferred that they had formed under acidic and oxidizing conditions. The rover, they quipped, had discovered evidence not of water but of acid on Mars.

Nothing daunted, Opportunity struggled out of Endurance and trundled off toward Argo, the next-nearest crater. It was to crater-hop for the next nine years, checking out Argo, Vostok, Erebus, Victoria, Conception and Santa Maria, but encountering the Burns Formation everywhere it went.

And then, finally, it drove to Endeavour, a monster crater, measuring a full 14 miles across. Formed by the impact of an asteroid or a comet, perhaps 4 billion years ago, the crater has been filled in by Burns Formation sandstones, but a few islands of rock still stand exposed on the rim.

“They’re ancient rocks that predate the Endeavour impact,” Arvidson said. Rather than enter the crater, Opportunity stayed on its rim to look at those rocks.

“We drove to a spot on the rim called Cape York because the CRISM instrument on the Mars Reconnaissance Orbiter had identified the spectral signature of clay materials on its eastern side,” Arvidson explained.

At Cape York, the rover ground into a rock called Espérance. The deeper it ground, the more the rock’s composition resembled that of an aluminum-rich clay called montmorillonite.

“To make an aluminum-rich clay,” Arvidson explained, “you have to leach many other elements out of the rock, such as iron and magnesium. So this is a place a lot of water flowed through, probably because fracturing made the rock very permeable.

“If you go through the chemistry and infer characteristics of the water, it was mildly acidic at best and reducing, not oxidizing, and those are habitable conditions. We think this kind of environment existed many places on Mars,” he said.

What happened to Mars?

But if Mars was once warm and wet, what happened to turn it cold and dry?

“Early Mars was volcanically active,” Arvidson said. “The volcanoes would have pumped greenhouse gases into the atmosphere that warmed the planet. It also had an internal magnetic field that deflected the solar wind, preventing it from stripping away the atmosphere. But as the core of the planet froze, its magnetic field diminished, the solar wind scoured away the atmosphere, and without a dense atmosphere, it became the cold, dry planet we know today.

“That’s what the geologists think,” he said. “So we’re convincing the atmosphere modelers to give us enough greenhouse oomph, with whatever gas they want, in order to get up to temperature where there would be liquid water on the surface. Because the geological evidence says, ‘That’s a fact, Jack.'”

The Boffins-in-training all stood up and cheered.

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Disturbingly High Levels Of Carcinogen Found In Diet Sodas

Brett Smith for redOrbit.com – Your Universe Online

An investigation by Consumer Reports has revealed troublingly high levels of a carcinogenic brown food coloring in Pepsi One and Goya Malta sodas.

Although there are no limits on the use of the investigated food additive, also known as 4-methylimidazole (4-MeI) or caramel color, California has the substance on its Proposition 65 list of carcinogens. Passed in 2011, the California law requires a food or beverage to have a health warning label if it exposes consumers to over 29 micrograms of 4-MeI a day.

“There’s no reason why consumers should be exposed to an avoidable and unnecessary risk that can stem from coloring food brown,” said Urvashi Rangan, a toxicologist and executive director of Consumer Reports’ Food Safety & Sustainability Center. “Manufacturers have lower 4-MeI alternatives available to them. Ideally there would be no 4-MeI in food.”

To reach their conclusion, researchers with Consumer Reports tested 81 cans and bottles of various soft drinks from five manufacturers between April and September 2013. The soft drinks were purchased from stores in California and the greater New York City area. In December 2013, the research team tested 29 new samples bought in the same areas of those brands that had initially tested above 29 micrograms per container.

“While our study was not large enough to recommend one brand over another, both rounds of testing found that the level of 4-MeI in the samples of Pepsi One and Malta Goya purchased in both locations exceeded 29 micrograms per can or bottle,” Consumer reports said in a press release. “The products we purchased in California did not have a cancer-risk warning label.”

The researchers said their initial testing on brands purchased in California had average 4-Mel levels around or below 29 micrograms per can. However, the New York area samples of those same brands tested significantly higher. During follow-up testing, 4-Mel levels in the New York samples were lower. For example, original Pepsi from the New York City area averaged over 170 micrograms in the first test and 32 micrograms in the second.

“The fact that we found lower amounts of 4-MeI in our last round of tests suggests that some manufacturers may be taking steps to reduce levels, which would be a step in the right direction,” Rangan said.

The researchers noted that Coke, Diet Coke, and Coke Zero all tested below 5 micrograms per can, a level Consumer Reports’ determined to be much more acceptable.

Consumer Reports said it contacted PepsiCo and Goya in January 2014 to find out if their products sold in California complied with the state law.

“When the regulatory requirements changed in California, PepsiCo moved immediately to meet the new requirements,” a PepsiCo spokesperson responded via e-mail, adding that reformulated products with lower levels of 4-MeI would be available nationwide by February 2014. Goya did not respond to the request.

After PepsiCo was informed of the test results, the company released a statement that noted Proposition 65 is based on per day, not per can, exposure – adding that government data shows the standard amount consumed by diet soda drinkers is 100 milliliters per day, or less than one-third of a 12-ounce can.

“No matter how much consumers drink they don’t expect their beverages to have a potential carcinogen in them,” Rangan said. “And we don’t think 4-MeI should be in foods at all. Our tests of Coke samples show that it is possible to get to much lower levels.”

Study Re-examines The Evolutionary Origins Of Lactose Tolerance

Ranjini Raghunath for redOrbit.com – Your Universe Online

Life in current times sure beats living in the Stone Ages. But there is one trait that many modern humans often take for granted – a trait that their primitive ancestors didn’t have: lactose persistence, or the ability to drink milk and not get cramps, flatulence or diarrhea.

How and why humans evolved this ability to tolerate lactose has long fascinated evolutionary biologists, as milk has now become a dietary staple throughout much of the world. Most modern humans of European descent are lactose persistent, which means they can produce the enzyme lactase which breaks down the milk sugar lactose into glucose during digestion.

Our Stone Age ancestors, however, didn’t have this luxury. Lactose persistence has evolved only over the last ten thousand years. The secret lies in the genes: over time, European descendents have developed a unique mutation in their genes that allows them to produce the enzyme lactase.

Archaeologists have shown that the ability first evolved in farming populations. A popular theory fielded by biologists is that natural selection favored its evolution so farming populations would not succumb to calcium deficiency. This was especially likely among early European farmers who didn’t get much sunlight which helps the body naturally synthesize vitamin D. In turn, vitamin D is needed for the body to absorb calcium. Milk fortunately has plenty of both calcium and vitamins.

Now, a new study by researchers at Uppsala University and Stockholm University, Sweden shows that the calcium-and-sunlight theory might not give the entire picture.

One question that the theory raises is: what about people who used to live in sunny regions such as Spain? They had all the vitamin D they ever needed. Why did they also need to develop this ability to digest milk if there was no evolutionary pressure to do so?

“If natural selection is driving lactase persistence evolution in a place where people have no problems making vitamin D in their skin, then clearly the vitamin D and calcium explanation (known as the calcium assimilation hypothesis) isn’t cutting it,” said Oddný Sverrisdóttir, lead author of the paper said. “So while the calcium assimilation hypothesis may have some relevance in Northern Europe it’s clearly not the whole story.”

To test the theory, the researchers carefully recovered DNA samples from the bones of ancient Spanish farmers and examined them. To their surprise, they found that the lactose mutation was absent in their genes, although most Spanish descendants today do have lactose persistence.

“The evolution of lactase persistence is one of the best known and most dramatic examples of recent human evolution. One of the ironies of working in this area is that we know it happened but we still don’t fully know why,” Sverrisdóttir stated.

He and his colleagues have proposed an alternate explanation. Famine could have been the trigger, they suggest in their paper published in the journal Molecular Biology and Evolution.

Before early European farmers developed this ability, when they couldn’t drink milk without showing the related symptoms, they could still opt for fermented milk products such as yogurt and cheese. This is because, during fermentation, most of the lactose gets converted into fats.

When crops failed and famine hit, however, they most likely ran out of their fermented products supply and had no choice but to go for milk and other high-lactose products. Given a choice between dying from hunger and diarrhea from milk, they most likely chose the latter. Over time, they probably began to develop a stronger stomach and a tolerance to the effects of milk, the researchers believe.

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What Is Adam’s Rightful Place In Evolutionary History?

University of Sheffield

Our most common male ancestor walked the earth 209,000 years ago – earlier than scientists commonly thought – according to new research from the University of Sheffield.

The pioneering study, conducted by Dr Eran Elhaik from the University of Sheffield and Dr Dan Graur from the University of Houston, also debunked the discovery of the Y chromosome that supposedly predated humanity.

In the new research, published in the European Journal of Human Genetics, Dr Elhaik and Dr Graur used conventional biological models to date our most common male ancestor ‘Adam’ in his rightful place in evolutionary history. The ground breaking results showed that this is 9,000 years earlier than scientists originally believed.

Their findings put ‘Adam’ within the time frame of his other half ‘Eve’, the genetic maternal ancestor of mankind. This contradicts a recent study which had claimed the human Y chromosome originated in a different species through interbreeding which dates ‘Adam’ to be twice as old.

Debunking unscientific theories is not new to Dr Elhaik. Earlier this year he debunked Hammer’s previous work on the unity of the Jewish genome and together with Dr Graur they refuted the proclamations made by the ENCODE project on junk DNA.

“We can say with some certainty that modern humans emerged in Africa a little over 200,000 years ago,” said Dr Elhaik.

“It is obvious that modern humans did not interbreed with hominins living over 500,000 years ago. It is also clear that there was no single ‘Adam’ and ‘Eve’ but rather groups of ‘Adams and ‘Eves’ living side by side and wandering together in our world.”

Dr Elhaik added: “We have shown that the University of Arizona study lacks any scientific merit.

“In fact, their hypothesis creates a sort of ‘space-time paradox ‘whereby the most ancient individual belonging to Homo sapiens species has not yet been born. If we take the numerical results from previous studies seriously we can conclude that the past may be altered by the mother of ‘Adam’ deciding not to conceive him in the future, thus, bringing a retroactive end to our species.

“Think of the movie Back to the Future, when Marty was worried that his parents would not meet and as a result he wouldn’t be born – it’s the same idea.

“The question to what extend did our humans forbearers interbreed with their closest relatives is one of the hottest questions in anthropology that remains open.”

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‘Space Cop’ Mini-Satellites Set To Patrol Interstellar Traffic Beat

redOrbit Staff & Wire Reports – Your Universe Online

Researchers from the Lawrence Livermore National Laboratory (LLNL) in California have developed and tested a series of ground-based mini-satellites that will be used to help control traffic in space.

These so-called “space cops” were used by the LLNL team to capture a series of six images over a 60-hour period to prove that they can be used to alter the orbit of other probes traveling in low-earth orbit. The plan is to use the satellite network to help prevent increasingly-common collisions of satellites and space debris.

“Eventually our satellite will be orbiting and making the same sort of observations to help prevent satellite-on-satellite and satellite-on-debris collisions in space,” explained Lance Simms, a computational engineer at LLNL and the lead author of a paper appearing in a future edition of the Journal of Small Satellites.

According to Sharon Gaudin of Computerworld, potential collisions between non-operational satellites and other bits of space junk are becoming an increasing area of concern for probe operators. For example, last spring, NASA’s Fermi Gamma-ray Space Telescope had a near-miss with a defunct 3000-pound Cold War era Soviet spy satellite.

Without an “eleventh-hour maneuver” completed by engineers with the US space agency, “the two objects, which are speeding around the Earth at thousands of miles an hour in perpendicular orbits, were expected to come within 700 feet of each other,” she added. “A collision would have led to further problems since NASA calculated that, with a speed relative to Fermi’s of 27,000 mph, a collision would have released as much energy as two-and-a-half tons of high explosives, destroying both spacecraft and further littering Earth’s orbit with dangerous debris.”

The LLNL’s Space-Based Telescopes for Actionable Refinement of Ephemeris (STARE) mission is an effort to prevent these types of collision scares. STARE will consist of a constellation of low-earth orbit nano-satellites designed in order to refine the orbits of satellites and space debris to less than 100 meters.

Project leader Wim de Vries and the rest of the STARE team have used the ground-based satellite to refine the orbit of the NORAD 27006 satellite based on four observations made during the first 24 hours of its flight. In addition, they predicted its trajectory to within less than 50 meters over the next 36 hours, the researchers explained.

“By refining the trajectory of NORAD 27006 with their ground-based payload, the team believes they will be able to do the same thing for other satellites and debris once their payload is orbiting earth,” the team told LLNL’s Anne M Stark in a statement. “The tools and analysis used to capture the images of NORAD 27006 and refine its orbit are the same ones that will be used during the STARE mission.”

“Accurately predicting the location of a satellite in low earth orbit at any given time is difficult mainly because of the uncertainty in the quantities needed for the equations of motion,” the researchers added. “These uncertainties and the incompleteness of the equations of motion lead to a quickly growing error in the position and velocity of any satellite being tracked in low earth orbit.”

In order to account for those errors, the Space Surveillance Network (SSN) needs to repeatedly observe all of the approximately 20,000 objects it tracks. However, since the positional uncertainty of an object is roughly one kilometer, there are approximately 10,000 false alarms for each anticipated collision.

“With these large uncertainties and high false alarm rates, satellite operators are rarely motivated to move their assets after a collision warning is issued,” the researchers said, adding that while the STARE mission is looking to reduce that margin of uncertainly to “100 meters or smaller,” the LLNL team was “able to reduce the uncertainty to 50 meters, well below the 100-meter goal.”

Image 2 (below): From left to right: Brian Bauman, Vincent Riot, Darrell Carter, Lance Simms and Wim De Vries have developed and tested land-based mini-satellites that eventually will be used in space to help control traffic in space. Photo by Julie Russell/LLNL

‘Icy’ Technique Improves Robotic Kidney Transplants

A collaboration of surgeons at Henry Ford Hospital and Medanta Hospital in India successfully transplanted kidneys into 50 recipients using an innovative robot-assisted procedure in which the organ is cooled with sterile ice during the operation.

The research project – published online ahead of print in European Urology, the journal of the European Association of Urology – advances minimally invasive robotic surgery as a safe alternative to traditional open surgery.

“Minimally invasive surgery reduces post-operative pain and minimizes complications in comparison to conventional surgery,” says Mani Menon, M.D., chair of Henry Ford’s Vattikuti Urology Institute and co-author of the study.

“The benefits of minimally invasive surgery in removing donor kidneys has been well established in earlier studies, but the use of robot-assisted surgery in transplanting those kidneys is comparatively a frontier,” Dr. Menon adds.

The Henry Ford researchers and their counterparts in Gurgaon, India, reasoned that since minimally invasive robotic surgery has proven to be a great benefit to healthy kidney donors, it might also be a boon to the ill and weakened transplant recipients who are at greater risk of complications. But they noted British research from 1971 that showed that kidney function was partially impaired in recipients if blood flow was interrupted for longer than 30 minutes during transplant.

So they decided to chill both the donor kidney and the transplant site with sterile ice slush in hopes of increasing the amount of time in which they could safely learn and perfect the robot-assisted surgery.

“To our knowledge, ours is the first study to use renal cooling during robotic kidney transplant,” Dr. Menon says. “It had already proved useful during minimally invasive prostate surgeries.”

After three years of planning and simulated surgeries at Henry Ford, 50 consecutive transplant patients who had volunteered for the minimally invasive procedure underwent robotic kidney transplant at Medanta Hospital between January and October 2013.

In all, Medanta Hospital has performed 54 operations and International Kidney and Renal Diseases at Ahmedabad, India, has done 56 operations, for a total of 110 transplants in one year. The surgeons in charge of the two programs are Dr. Rajesh Ahlawat and Dr. Pranjal Modi.

In each case, surgeons filled the kidney cavity with ice slush through a specially designed port in the patient’s abdomen before transplanting the donor kidney, which was also chilled with ice slurry held in place by gauze wrapping.

Blood vessels were attached to the transplanted kidney using suturing techniques refined in other types of minimally invasive procedures. Immediately after transplant, all of the grafted kidneys functioned normally and patient levels of creatinine – used to measure kidney function – were well within normal range.

None of the patients developed blood or urine leaks, infections or other complications from their surgical wounds. None required dialysis after surgery.

When given follow-up exams six months after surgery, nearly all of the first 25 patients who underwent the procedure developed no complications, although two required exploratory surgery and one died of acute congestive heart failure.

Dr. Menon attributed the success of the study in part to “the seamless collaboration” between surgeons experienced in conventional “open surgery” kidney transplants and surgeons skilled in using robotic techniques.

By the time they began the study, the teams from Henry Ford and Medanta hospitals had performed more than 10,000 robotic procedures and 2,500 conventional kidney transplants.

“The individual surgeons involved had built an atmosphere of trust and mutual respect over 30 years of collaborative work,” Dr. Menon says. “While this benefit can’t be precisely measured, it clearly contributed to the success of this endeavor.”

The researchers noted that further studies will be needed before robotic kidney transplant is widely accepted as a “reasonable” alternative to conventional transplantation.

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Bio-Inspired Robotic Device Could Help Patients With Ankle-foot Disorders

Carnegie Mellon University
A soft, wearable device that mimics the muscles, tendons and ligaments of the lower leg could aid in the rehabilitation of patients with ankle-foot disorders such as drop foot, said Yong-Lae Park, an assistant professor of robotics at Carnegie Mellon University.
Park, working with collaborators at Harvard University, the University of Southern California, MIT and BioSensics, developed an active orthotic device using soft plastics and composite materials, instead of a rigid exoskeleton. The soft materials, combined with pneumatic artificial muscles (PAMs), lightweight sensors and advanced control software, made it possible for the robotic device to achieve natural motions in the ankle.
The researchers reported on the development in the journal Bioinspiration & Biomimetics.
Park, who did the work while a post-doctoral researcher at Harvard’s Wyss Institute for Biologically Inspired Engineering, said the same approach could be used to create rehabilitative devices for other joints of the body or even to create soft exoskeletons that increase the strength of the wearer.
The robotic device would be suitable for aiding people with neuromuscular disorders of the foot and ankle associated with cerebral palsy, amyotrophic lateral sclerosis, multiple sclerosis or stroke. These gait disorders include drop foot, in which the forefoot drops because of weakness or paralysis, and equinus, in which the upward bending motion of the ankle is limited. Conventional passive ankle braces can improve gait, but long-term use can lead to muscle atrophy because of disuse.
Active, powered devices can improve function and also help re-educate the neuromuscular system, Park said. “But the limitation of a traditional exoskeleton is that it limits the natural degrees of freedom of the body,” he added. The ankle is naturally capable of a complicated three-dimensional motion, but most rigid exoskeletons allow only a single pivot point.
The soft orthotic device, by contrast, enabled the researchers to mimic the biological structure of the lower leg. The device’s artificial tendons were attached to four PAMs, which correspond with three muscles in the foreleg and one in the back that control ankle motion. The prototype was capable of generating an ankle range of sagittal motion of 27 degrees — sufficient for a normal walking gait.
The tradeoff, however, is that the soft device is more difficult to control than a rigid exoskeleton. It thus required more sophisticated sensing to track the position of the ankle and foot and a more intelligent scheme for controlling foot motion, Park said.
Among the innovations in the device are sensors made of a touch-sensitive artificial skin, thin rubber sheets that contain long microchannels filled with a liquid metal alloy. When these rubber sheets are stretched or pressed, the shapes of the microchannels change, which in turn causes changes in the electrical resistance of the alloy. These sensors were positioned on the top and at the side of the ankle.
Park said additional work will be necessary to improve the wearability of the device. This includes artificial muscles that are less bulky than the commercially produced PAMs used in this project. Park said a subsequent project, which will be presented at an upcoming technical conference, used flat, strap-like actuators instead of the cylindrical PAMs.
The device has yet to be tested on patients to determine its performance as a rehabilitative tool.
[ Watch The Video: Bio-Inspired Active Soft Orthotic Device ]
This research was sponsored by the Wyss Institute and the National Science Foundation.

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Late Night Smartphone Work Disrupts Sleep, Drains Productivity

redOrbit Staff & Wire Reports – Your Universe Online
Working on a smartphone late at night can ruin a good night’s sleep and drain productivity the following day, according to new research from the University of Washington’s Foster School of Business.
“Smartphones are enormously valuable for helping people fit work activity into times and places outside of the office,” the researchers said. “However, our new research indicates the greater connectivity comes at a cost: using a smartphone to cram more work into a given evening results in less work done the next day,” the researchers wrote in a Harvard Business Review blog post summarizing the study’s findings.
“Smartphones are bad for sleep, and sleep is very important to effectiveness as an employee.”
Lead researcher Christopher Barnes, assistant professor of management at the UW’s Foster School of Business, said smartphones are almost perfectly designed to disrupt sleep. They keep us mentally engaged with work late into the evening, making it harder to detach, relax, and get the deep sleep needed to recharge our mental batteries.
They also encourage poor sleep hygiene, a set of behaviors that make it harder to both fall asleep and stay asleep. Perhaps the most difficult aspect of smartphones when it comes to sleep is that they expose us to light, including blue light, which in even small amounts inhibits the sleep-promoting chemical melatonin.
Barnes and colleagues conducted two studies to evaluate the effect of late night smartphone work on sleep and productivity. In the first study, 82 mid- to high-level managers completed multiple daily surveys over the course of two weeks. The results confirmed that late night smartphone use cut into sleep and made the managers tired and less engaged in work the following day.
In the second study, 161 employees from a variety of occupations (both managers and non-managers) completed the same set of surveys, with the addition of measures of late night usage of television, laptop computers and tablets. The results showed that the harmful effects of smartphones on sleep and work engagement held true even after accounting for these other electronic devices. Indeed, out of all those devices, smartphones were associated with the most powerful effects.
The researchers advise managers to find new ways to balance the positive and negative aspects of smartphone use, such as adopting a predictable time off each day and a set time to power down and psychologically disengage from work. They also recommend establishing new norms for times employees are expected to respond to e-mails and other messages.
“As smartphones become more embedded in our daily lives, we should continue to seek solutions that will enable us to stay in touch with smartphones and still get the sleep we need to be effective the next day,” they wrote.
“In contrast to a short-term perspective that puts the current work item as the top priority, a perspective that focuses on longer-term performance will leave more room for managing smartphones in a manner that preserves sleep.”
“The more important the job, the more important it is to work with a fresh brain. We would do well to remember that, and not let our phones call the shots.”
A report about the study, entitled: “Beginning the Workday yet Already Depleted? Consequences of Late-Night Smartphone Use and Sleep,” will be published later this year in the journal Organizational Behavior and Human Decision Processes.

Sitting: Is It As Bad For You As Smoking?

[ Watch the Video: Get Up And Move! Sitting May Be As Bad As Smoking ]

redOrbit Staff & Wire Reports – Your Universe Online

Spending long hours sitting on the job has already been established as a potential health hazard, but now medical experts are saying that it could be as harmful to a person’s overall welfare as smoking cigarettes.

According to a special report by CBS New York, published research has already linked prolonged period of sitting to an increased risk of cardiovascular disease, obesity, diabetes, cancer and premature death. But is it as hazardous to your health as smoking?

“Smoking certainly is a major cardiovascular risk factor, and sitting can be equivalent in many cases,” explained Dr. David Coven, a cardiologist at St. Luke’s-Roosevelt Hospital Center. “The fact of being sedentary causes factors to happen in the body that are very detrimental.”

The answer, recent studies have suggested, is to become more physically active. Exercising more and sitting less were positively linked to improved overall health and quality of life, but it can be difficult to be adequately active when a person has to be parked at a desk or in front of a computer for eight or more hours per day.

Fortunately, Dr. Dermont Phelan of the Cleveland Clinic said that being active doesn’t necessarily mean that a person has “to go to the gym for 30 minutes in the day.” Instead, just taking “a brisk walk” for about “10 minutes three times a day” is sufficient.

“While not an equal substitute for exercise, some doctors recommend getting up once an hour from your desk, even if it’s just to walk around briefly or go to the bathroom,” CBS New York said. “Some people have even started using combination treadmill desks at work — anything that contracts our muscles and gets blood flowing.”

However, research published Tuesday in the American Heart Association journal Circulation: Heart Failure suggests that even men who exercise regularly experienced an increased risk of heart failure if they spend long periods of time sitting.

This finding, lead researcher and Kaiser Permanente scientist Dr. Deborah Rohm Young and her colleagues reported, suggests that both high levels of physical activity and low levels of sedentary time were required to remain healthy.

Dr. Young’s team followed a group of over 84,000 males between the ages of 45 and 69, and found that men with lower levels of physical activity were 52 percent more likely to develop heart failure than those with high physical activity levels, even after adjusting for differences in sedentary time.

“Outside of work, men who spent five or more hours a day sitting were 34 percent more likely to develop heart failure than men who spent no more than two hours a day sitting, regardless of how much they exercised,” the American Heart Association said in a statement. “Heart failure risk more than doubled in men who sat for at least five hours a day and got little exercise compared to men who were very physically active and sat for two hours or less a day.”

Similarly, in February 2013, research published in the International Journal of Behavioral Nutrition and Physical Activity found that the more time a person spent in the seated position, the higher risk they faced of developing a chronic disease such as diabetes, cancer or high blood pressure.

In that study, researchers from Kansas State University and the University of Western Sydney looked at over 63,000 Australian men between the ages of 45 and 65 years old. The study participants answered questions about any existing chronic diseases and reported their daily sitting time, and were then divided into four different categories based on the number of time they were sedentary during an average day.

Those who reported sitting for less than four hours per day were found to be no more likely to develop a chronic disease, but the risk rate increased in correlation with the amount of time spent sitting, the study found. Those who sat for eight hours or more on a daily basis were the most likely to develop a chronic disease.

Occurrence Of Deadly Amphibian Disease Dictated By Micropredators

Helmholtz-Center for Environmental Research
An international team of researchers has made important progress in understanding the distribution of the deadly amphibian chytrid pathogen. In some regions, the deadly impact of the pathogen appears to be hampered by small predators, naturally occurring in freshwater bodies. These micropredators may efficiently reduce the number of free-swimming infectious stages (zoospores) by consuming them. This natural behavior will reduce the infection pressure on potential amphibian hosts and a goes a long way towards explaining the occurrence of chytridiomycosis, at least in temporal climatic regions. These results were published in the renowned scientific journal Current Biology. The team of researchers state that their results raise the hope of successfully fighting chytridiomycosis, nowadays one of the most deadly wildlife diseases.
The entire class of the amphibians is greatly affected by the current wave of global extinctions. Although anthropogenic habitat alteration and fragmentation are the most important causes of amphibian biodiversity loss, mere conservation of amphibian habitats no longer guarantees amphibian survival. Indeed, the introduction of infectious diseases has been shown to drive amphibians to extinction even in seemingly pristine habitats. “The current amphibian decline is a disaster for ecosystems around the world,” says Dr. Dirk S. Schmeller from the Helmholtz-Center for Environmental Research (UFZ) and the CNRS Unit Ecolab, and adds “Amphibians have key roles in freshwater ecosystems, and when they are gone, far going changes are unavoidable.”
Chytridiomycosis is a disease which is devastating amphibians around the world. It is caused by the deadly chytrid skin fungus (Batrachochytrium dendrobatidis), or Bd, as scientists call it in short. Bd infects the skin of amphibians, which is an important respiratory organ for them, allowing them to breathe also in the water. “Bd needs to establish in a new environment and has usually a tight time window to infect a suitable host, either an adult amphibian or tadpoles and larvae of this species group,” says veterinarian Prof. Dr. Frank Pasmans from the University of Ghent.
If Bd successfully establishes, infections will steadily increase and above a certain threshold, amphibians will start dying. In vulnerable species, local extinction can occur. In this manner many species have been lost, especially in Central America and tropical Australia. However, this worst case scenario did not occur in all populations of the Midwife Toad A. obstetricans in the Pyrenean Mountains, the main study area of the Biodiversa-project RACE, which intrigued scientists. They started a whole range of experiments, which took over three years to complete, to understand, which differences between different ponds and lakes of the Pyrenees could explain such a pattern. “The infected lakes and ponds did not look like the uninfected ones, neither in regard to the vegetation nor in regard to the geological characteristics,” says Dirk S. Schmeller. “When we brought in water from infected and uninfected sites, in some cases with help from donkeys, we saw clear differences in laboratory cultures of the pathogen, as well as in the infection dynamics.” A series of additional experiments than clearly established that some microscopic aquatic predators, such as protozoans and rotifers, are capable of consuming large quantities of the infectious stage of Bd. “The consumption of zoospores reduces the infection pressure for the whole population by reducing the number of infected tadpoles,” says Mark Blooi from the University of Ghent.
Water bodies that do not support a diverse and abundant micropredator community, such as those that suffer from anthropogenic and environmental pressures, could lead to higher infection rates that lead to outbreaks of disease and amphibian population crashes. Dr. Adeline Loyau from the Helmholtz-Center for Environmental Research and the CNRS Unit Ecolab adds: “The big question to rapidly answer is, if by steering micropredator abundance and community composition, can we alleviate the impact of chytridiomycosis in natural amphibian populations? And if so, does this offer a realistic method for preservation of amphibians in Bd infected areas around the world.” The work, conducted by an international research team financed by the Biodiversa-Project RACE, raises the hope for an effective biocontrol against the Chytrid fungus, one without the downsides associated with introducing nonnative biocontrol agents, such as the use of antifungal chemicals or release of nonnative skin bacteria into the environment, or the reliance of unpredictable environmental temperature to ‘‘cure’’ infections. The study also contributes to a better understanding on how ecosystem health is linked to the establishment of pathogens in new environments, as only in healthy ecosystems the community of microorganisms might be able to consume zoospores effectively.

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Real-Time Neurofeedback Helps Retrain The Brain

Brett Smith for redOrbit.com – Your Universe Online

Ever wonder what your brain is thinking? Well, a new device developed by scientists from the Montreal Neurological Institute and Hospital at McGill University enables people to see their own brain activity in real time and control or adjust function in specific brain regions.

In their report, which was published in the journal NeuroImage, The McGill team speculated that their device could be used as a possible remedial tool to manage and train targeted brain regions.

The novel device uses magnetoencephalography (MEG), a non-invasive imaging technology that tracks magnetic fields generated by neurons in the brain. The team said the main advantage MEG has over other imaging technologies is its unmatched time resolution.

“This means you can observe your own brain activity as it happens,” said study author Sylvain Baillet, acting director at the neurological institute. “We can use MEG for neurofeedback – a process by which people can see on-going physiological information that they aren’t usually aware of, in this case, their own brain activity, and use that information to train themselves to self-regulate.”

“Our ultimate hope and aim is to enable patients to train specific regions of their own brain, in a way that relates to their particular condition,” Baillet added. “For example neurofeedback can be used by people with epilepsy so that they could train to modify brain activity in order to avoid a seizure.”

In the study, participants were asked to look at a colored disc on a display screen and use their brain activity to change the disc’s color from dark red to bright yellow white, as well as maintain that bright color for as long as possible. Study researchers tied disc color to very specific regions of the motor cortex in the participants’ brain. The disc color would change based on a predefined permutation of slow and fast brain activity within these regions. Participants had nine sessions in the MEG to reach their target.

“The remarkable thing is that with each training session, the participants were able to reach the target aim faster, even though we were raising the bar for the target objective in each session, the way you raise the bar each time in a high jump competition,” the researchers said.

“These results showed that participants were successfully using neurofeedback to alter their pattern of brain activity according to a predefined objective in specific regions of their brain’s motor cortex, without moving any body part. This demonstrates that MEG source imaging can provide brain region-specific real time neurofeedback and that longitudinal neurofeedback training is possible with this technique.”

The technology has shown promise in treating epileptic patients. The McGill team said there is great potential in using MEG to investigate other neurological syndromes and disorders.

The team is currently using the technology to work with people that have amusia, a condition that disrupts the processing musical pitch. Amusia is thought to be caused by poor communication between the auditory cortex and prefrontal regions in the brain. By measuring the intensity of connectivity between these brain regions in amusic patients, the team is trying to take advantage of the brain’s agility to strengthen the functional connectivity between the brain regions. If researchers see an improvement in pitch discrimination for participants, it will show the clinical and rehabilitative applications of this technology.

As WhatsApp Hits 430M Users, Founder Vows No Ads, No Games, No Gimmicks

Brett Smith for redOrbit.com – Your Universe Online
The WhatsApp messaging app has just passed the 430 million-user mark and at a recent conference in Munich, Germany. WhatsApp founder Jan Koum said his company is focused primarily on user experience and not “gimmicks” such as games or disappearing photos – the latter an obvious reference to the messaging app Snapchat.
Koum said the app will continue to be ad-free, relying on subscription fees to bring in revenue. The app was originally offered for free, but now costs .99 cents per year to use after the first year.
“No ads, no games, no gimmicks,” Koum said.
That has become something of a company motto – originally written on a Post-It note by co-founder Brian Acton, who used to work with Koum at Yahoo. Koum said he keeps the note as a reminder of where WhatsApp should remain focused.
“We just want to focus on messaging. If people want to play games there are plenty of other sites and also a lot of great companies building services around advertising,” Koum noted.
The company founder and chief executive refused to mention whether WhatsApp is currently profitable or disclose any significant financial details.
“We are not focus on monetization today because we are still growing,” the Ukrainian-born Koum said. “Someday in the future we will focus on monetization but today we’re more interested in making sure that those people who signed up have a great user experience.”
Koum said his experiences growing up in a satellite-state of the Soviet Union and emigrating to the United States have played a significant role in how WhatsApp’s business model was envisioned and developed, from the no-ads policy, to the reliable and inexpensive communications, to the startup’s privacy policy. As an example, Koum recalled how expensive and difficult it was for immigrants with limited resources to make phone calls from the US to the Ukraine.
“With WhatsApp you don’t have to pay (excessive) fees,” he said.
He added that the ad-free nature of Whatsapp is inspired by his life before experiencing the onslaught of American advertising.
“I grew up in a country where advertising didn’t exist and I had a remarkable childhood,” he said. “Looking back it was an idealistic environment. Even though there were thousands of problems, the joy of growing up in an uncluttered lifestyle (meant) you could focus on other things.”
Koum said his Cold War upbringing has also inspired the company’s privacy policy.
“I remember my parents having no conversations on the phone. The walls had ears and you couldn’t speak freely,” Koum recalled. “It is extremely important (for us) to provide a level of security and privacy…. We don’t collect people’s personal information. We just know your phone number and those of the people you want to message with.”
In the conference discussion hosted by Wired’s David Rowan, the tech mogul also admitted a preference for Android over iOS.
“Android is a lot more open,” Koum said. “We are able to build new features and prototype faster on Android, not to mention that we have a lot more users on Android.”
Despite this personal preference, Koum said his company ultimately wants “to be on every smartphone.”

Vitamin D Can Help Slow Progression Of Early-Stage Multiple Sclerosis

Karen Feldscher, Harvard School of Public Health

For patients in the early stages of multiple sclerosis (MS), low levels of vitamin D were found to strongly predict disease severity and hasten its progression, according to a new study led by Harvard School of Public Health (HSPH) investigators in collaboration with Bayer HealthCare. The findings suggest that patients in the early stages of MS could stave off disease symptoms by increasing their vitamin D intake.

“Because low vitamin D levels are common and can be easily and safely increased by oral supplementation, these findings may contribute to better outcomes for many MS patients,” said lead author Alberto Ascherio, professor of epidemiology and nutrition at HSPH.

The study was published online January 20, 2014 in JAMA Neurology.

MS is a central nervous system disease that causes problems with muscle control and strength, vision, balance, feeling, and thinking. It’s estimated by the World Health Organization that roughly 2.5 million people in the world have MS.

Previous research indicated a connection between low levels of vitamin D and risk of developing MS or having MS symptoms worsen, but those studies included patients with longstanding MS whose vitamin D levels could partly be a consequence, not a predictor, of disease severity. The new study looked at vitamin D levels among patients at the time of their first symptoms of the disease.

Researchers analyzed data from 465 MS patients from 18 European countries, Israel, and Canada who enrolled in 2002 and 2003 in the BENEFIT (Betaseron in Newly Emerging Multiple Sclerosis for Initial Treatment) trial, which was aimed at comparing the effectiveness of early versus late interferon beta-1b in treating the disease. The scientists looked at how the patients’ vitamin D levels—which were measured at the onset of their symptoms and at regular intervals over a 24-month period—correlated with their disease symptoms and progression over a period of five years.

They found that early-stage MS patients who had adequate levels of vitamin D had a 57% lower rate of new brain lesions, a 57% lower relapse rate, and a 25% lower yearly increase in lesion volume than those with lower levels of vitamin D. Loss in brain volume, which is an important predictor of disability, was also lower among patients with adequate vitamin D levels. The results suggest that vitamin D has a strong protective effect on the disease process underlying MS, and underscore the importance of correcting vitamin D insufficiency, which is widespread in Europe and the U.S., the researchers said.

“The benefits of vitamin D appeared to be additive to those of interferon beta-1b, a drug that is very effective in reducing MS activity. The findings of our study indicate that identifying and correcting vitamin D insufficiency should become part of the standard of care for newly diagnosed MS patients,” said Ascherio.

HSPH’s Kassandra Munger, research associate in the Department of Nutrition, was a co-author on the study.

Funding for the study came from the National Institute of Neurological Diseases and Stroke and the National Multiple Sclerosis Society.

Sunlight May Help Lower Blood Pressure

University of Southampton
Exposing skin to sunlight may help to reduce blood pressure and thus cut the risk of heart attack and stroke, a study published in the Journal of Investigative Dermatology suggests.
Research carried out at the Universities of Southampton and Edinburgh shows that sunlight alters levels of the small messenger molecule, nitric oxide (NO) in the skin and blood, reducing blood pressure.
Martin Feelisch, Professor of Experimental Medicine and Integrative Biology at the University of Southampton, comments: “NO along with its breakdown products, known to be abundant in skin, is involved in the regulation of blood pressure. When exposed to sunlight, small amounts of NO are transferred from the skin to the circulation, lowering blood vessel tone; as blood pressure drops, so does the risk of heart attack and stroke.”
While limiting sunlight exposure is important to prevent skin cancer, the authors of the study, including Dr Richard Weller of the University of Edinburgh, suggest that minimizing exposure may be disadvantageous by increasing the risk of prevalent conditions related to cardiovascular disease.
Cardiovascular disease, often associated with high blood pressure, accounts for 30 per cent of deaths globally each year. Blood pressure and cardiovascular disease are known to vary according to season and latitude, with higher levels observed in winter and in countries further from the equator, where ultraviolet radiation from the sun is lower.
During the study, the skin of 24 healthy individuals was exposed to ultraviolet (UVA) light from tanning lamps for two sessions of 20 minutes each. In one session, the volunteers were exposed to both the UVA rays and the heat of the lamps. In another, the UV rays were blocked so that only the heat of the lamps affected the skin.
The results suggest that UVA exposure dilates blood vessels, significantly lowers blood pressure, and alters NO metabolite levels in the circulation, without changing vitamin D levels. Further experiments indicate that pre-formed stores of NO in the upper skin layers are involved in mediating these effects. The data are consistent with the seasonal variation of blood pressure and cardiovascular risk at temperate latitudes.
Professor Feelisch adds: “These results are significant to the ongoing debate about potential health benefits of sunlight and the role of Vitamin D in this process. It may be an opportune time to reassess the risks and benefits of sunlight for human health and to take a fresh look at current public health advice. Avoiding excess sunlight exposure is critical to prevent skin cancer, but not being exposed to it at all, out of fear or as a result of a certain lifestyle, could increase the risk of cardiovascular disease. Perhaps with the exception of bone health, the effects of oral vitamin D supplementation have been disappointing.
“We believe that NO from the skin is an important, so far overlooked contributor to cardiovascular health. In future studies we intend to test whether the effects hold true in a more chronic setting and identify new nutritional strategies targeted at maximizing the skin’s ability to store NO and deliver it to the circulation more efficiently.”

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Researchers Identify Process By Which Gut Bacteria Process Dietary Fiber

redOrbit Staff & Wire Reports – Your Universe Online

Scientists from the US, the UK, Canada and Sweden have discovered how our bodies process dietary fiber, a substance which can improve digestion and help people control their weight by making them feel full faster.

In the January 19 edition of the journal Nature, researchers from the Royal Institute of Technology (KTH), the University of British Columbia (UBC), the University of York and the University of Michigan Medical School explain how the complex dietary carbohydrates found in fruits and vegetables are metabolized by gut bacteria.

According to the researchers, there are roughly 100 trillion microbiota (bacteria living in human intestines) in the average person’s body, and they all play a vital role in human metabolism and overall well-being. One specific type of gut bacteria, Bacteroidetes, is responsible for digesting a type of complex sugar known as xyloglucans.

This sugar comprises up to one-fourth the dry weight of dietary fruit and vegetables, including onions, lettuce and tomatoes, and fully understanding the processes by which microbiota digest complex carbohydrates can help shed new insight on several different nutritional issues, such as the effect of prebiotics and probiotics on the body.

“While they are vital to our diet, the long chains of natural polymeric carbohydrates that make up dietary fiber are impossible for humans to digest without the aid of our resident bacteria,” explained senior author and UBC professor Harry Brumer. “This newly discovered sequence of genes enables Bacteroides ovatus to chop up xyloglucan, a major type of dietary fiber found in many vegetables.”

B. ovatus and its complex system of enzymes provide a crucial part of our digestive toolkit,” he added. “The next question is whether other groups in the consortium of gut bacteria work in concert with, or in competition with, Bacteroides ovatus to target these, and other, complex carbohydrates.”

Based on a survey of public genome data from 250 adults, Brumer and his co-authors reported that approximately 92 percent of the population possesses bacteria with a variant of this gene sequence. The findings could lead to tailored gut bacteria transplants in order to improve intestinal health following illness or antibiotic use.

“Despite our omnivorous diet, humans aren’t well equipped to eat complex plant matter; for this we rely on our gut bacteria. This work is helping us to understand the science of that process,” said professor Gideon Davies, who led the research at the University of York.

“The possible implications for commerce and industry extend beyond the realm of human nutrition, however,” he added. “The study of how enzymes break down plant matter is also of direct relevance to the development of processes for environmentally-friendly energy solutions such as biofuels.”

Self-Propelled Hybrid Bio-Bots Developed At University Of Illinois

redOrbit Staff & Wire Reports – Your Universe Online

Engineers from the University of Illinois have developed a new line of miniature, swimming bio-bots – the first class of synthetic structures capable of traveling through viscous biological fluids on their own.

Their bio-hybrid machines, which are detailed in the January 17 edition of the journal Nature Communications, can swim like sperm and are modeled after flagella, or single-celled creatures that have long tails, the researchers explained in a statement.

“Micro-organisms have a whole world that we only glimpse through the microscope,” said lead investigator Taher Saif, a mechanical science and engineering professor at the university. “This is the first time that an engineered system has reached this underworld.”

Saif and his colleagues began by creating the body of this bio-bot using a flexible polymer, and then they cultured heart cells near the junction of its head and tail. Those cells self-aligned and synchronized to beat together, sending a wave down the machines’ tails and propelling them forward, they explained.

According to the university, this self-organization is “a remarkable emergent phenomenon” and while they do not fully understand exactly how the cells on the flexible polymer tail are able to communicate with one-another, they have to beat together in the correct direction in order for movement to occur in the tail.

Saif explained that the bio-bots require “the minimal amount of engineering – just a head and a wire.” After that, the cells are introduced and begin interacting with the structure so that it can become functional. His team also built machines with two tails, which are capable of swimming even more quickly.

Creating aquatic bio-bots with multiple tails also makes it possible for them to navigate, the researchers said. They predict that future versions of these machines could be constructed in order to detect certain chemicals, sense light, or be instructed to travel towards a specific target for environmental or medical purposes.

“The long-term vision is simple,” explained Saif, who is also part of the university’s Beckman Institute for Advanced Science and Technology. “Could we make elementary structures and seed them with stem cells that would differentiate into smart structures to deliver drugs, perform minimally invasive surgery or target cancer?”

Saif was joined on the project by fellow University of Illinois researchers Brian J. Williams and Sandeep V. Anand, as well as Arizona State University’s Jagannathan Rajagopalan. Their work was completed as part of Emergent Behaviors in Integrated Cellular Systems (EBICS), a National Science Foundation-funded Science and Technology Center dedicated to building living, multi-cellular machines to solve real world problems.

“The most intriguing aspect of this work is that it demonstrates the capability to use computational modeling in conjunction with biological design to optimize performance, or design entirely different types of swimming bio-bots,” said EBICS director Roger Kamm, a professor of biological and mechanical engineering at the Massachusetts Institute of Technology (MIT). “This opens the field up to a tremendous diversity of possibilities. Truly an exciting advance.”

See an animation of the bio-bots in motion and a video of a free-swimming bot.

Image 2 (below): Engineers developed the first tiny, synthetic machines that can swim by themselves, powered by beating heart cells. Credit: Alex Jerez Roman, Beckman Institute for Advanced Science and Technology

Traditional Chinese Medicine May Stall Onset Of Diabetes

Brett Smith for redOrbit.com – Your Universe Online

Traditional Chinese medicine has been around for thousands of years, and a new study in the Journal of Clinical Endocrinology & Metabolism has found that a mixture of 10 Chinese herbal medicines called Tianqi may help stall the progression from a pre-diabetes condition to a formal diabetes diagnosis.

Patients are considered to have pre-diabetes when they develop elevated blood sugar levels, but not to the point of those with type-2 diabetes. Those with pre-diabetes face an elevated risk of developing full-blown type-2 diabetes, in addition to heart disease and stroke. According to the Centers for Disease Control and Prevention (CDC), approximately 79 million American adults age 20 years or older could be considered pre-diabetic.

“With diabetes evolving into a serious public health burden worldwide, it is crucial to take steps to stem the flood of cases,” said study authors Dr. Chun-Su Yuan, a recognized expert of herbal medicine at the University of Chicago. “Patients often struggle to make the necessary lifestyle changes to control blood sugar levels, and current medications have limitations and can have adverse gastrointestinal side effects. Traditional Chinese herbs may offer a new option for managing blood sugar levels, either alone or in combination with other treatments.”

In the study, nearly 390 volunteers at 11 research sites in China were randomly assigned to take either a capsule containing Tianqi or a placebo three times a day before meals for an entire year. All participants received healthy lifestyle instruction at the start of the trial and met intermittently with nutritionists. Researchers measured participants’ glucose tolerance on a quarterly basis.

After the year-long trial, 36 participants in the Tianqi group and 56 in the placebo group had developed type-2 diabetes. The study team found that the herbal medicine cut the risk of diabetes by over 32 percent compared to a placebo, after considering participants’ age and gender.

The team noted that risk reduction seen for Tianqi was as good as that seen in studies of the diabetes medications acarbose and metformin. Tianqi does include herbs that have been found to cut blood glucose levels and boost control of blood glucose levels after meals.

“Few controlled clinical trials have examined traditional Chinese medicine’s impact on diabetes, and the findings from our study showed this approach can be very useful in slowing the disease’s progression,” said study author Dr. Xiaolin Tong, from Guang’anmen Hospital in Beijing. “More research is needed to evaluate the role Chinese herbal medicine can play in preventing and controlling diabetes.”

Another study on traditional Chinese medicine published earlier this month in the journal Current Biology found that a chemical compound in the Corydalis plant can ease pain in mice. A chemical analysis performed by study researchers revealed a chemical in the plant – DHCB – was an effective pain reliever in the laboratory rodents.

“This medicine goes back thousands of years, and it is still around because it works,” Olivier Civelli, a study author and pharmacologist at the University of California, Irvine told the Los Angeles Times. “The question is, what makes it work. There are many compounds inside this plant.”

Over Time, Warning Labels Lead To Increased Purchases

Rebekah Eliason for redOrbit.com – Your Universe Online
Numerous products, such as cigarettes and medications, have elaborate warning labels that caution consumers about their risks. Most people would assume these warnings help lead people to make safer choices about the products.
Surprisingly, new research has discovered warning labels often have the opposite effect. According to Dr. Yael Steinhart of Tel Aviv University’s Recanati Business School, Professor Ziv Carmon of INSEAD in Singapore and Professor Yaacov Trope of New York University, if time elapses between product purchase and buying, consuming or evaluating the associated products, the presence of a warning label may encourage trust. This makes the potentially dangerous products seem less threatening.
“We showed that warnings may immediately increase concern and decrease consumption,” said Dr. Steinhart. “But over time, they paradoxically promote trust in a product and consequently lead to more positive product evaluation and more actual purchases.”
This discovery has significant implications for the regulators and managers of fields such as consumer products, healthcare and finance.
Professor Trope and Professor Nira Liberman of TAU’s School of Psychological Sciences developed “the construal-level theory” (CLT), which this study is based on. As people reflect on objects over time, the CLT suggests they often construe them abstractly and emphasize the “high-level” features while suppressing the “low-level features.”
Warning labels have a high-level feature by building trust and giving consumers the impression that all of the relevant information regarding the product has been presented. They also have a low-level feature by informing and making consumers aware of the negative side effects of the product.
According to the CLT, over long periods of time, consumers will de-emphasize the side effects and accentuate the feelings of trust from the warnings. This tendency may actually increase the purchase, consumption and assessment of the associated products.
In this study, the theory was tested using a series of experiments. For the first experiment, smokers were shown one of two ads, one with a health warning and one without, of an unfamiliar cigarette brand. Participants were separated into two groups. In the first group, people were told the cigarettes would arrive the following day. Those who had seen the warning showed an average decrease in cigarette purchases by 75 percent when compared to those who had not seen a warning. The second group was told the cigarettes would arrive in three months. The participants who had seen the warning increased their purchases by 493 percent when compared to those who were not shown the warning.
An additional experiment was conducted that presented ads to women for an artificial sweetener. Like the previous experiment they were either shown an ad with or without a health warning. If women were asked to order the sweetener immediately the warning was effective and decreased purchase of the sweetener an average of 94 percent. Women were then given the opportunity to buy the sweetener after two weeks and the amount of purchases increased by 265 percent.
Researchers suggest that consumer entities who want to minimize the deterrent effect of warnings should build in a purchase delay instead of hiding the warnings in fine print. On the contrary if the purpose is to genuinely inform customers about the risk of a product, they should repeat the warnings or ensure they are seen within a short time of purchase or consumption. This study was published in Psychological Science.

Anti-bullying Efforts May Boost Physical Fitness

Brigham Young University
A new study found that children who were bullied during P.E. class or other physical activities were less likely to participate in physical activity one year later.
Overweight or obese children who experienced teasing during physical activity had a lower perceived health-related quality of life (referring to physical, social, academic and emotional functioning) one year later. Even children with a healthy weight who were bullied during physical activity tended to exercise less often one year later.
Many previous studies have already correlated bullying with decreased physical activity among kids who are obese or overweight, but it was surprising to find that the correlation didn’t end there.
“Our finding that this applies to normal-weight kids also was novel,” said Chad Jensen, a psychology professor at BYU and lead author on the study published in the Journal of Pediatric Psychology.
This study looked at associations between bullying, physical activity and quality of life over time, following up with the same participants after a full year.
The participants in this study were 4th and 5th grade students from six different elementary schools in the Midwest. Participants completed three surveys at the beginning of the study and then completed the same three surveys again one year later.
The first survey asked questions about problems with health and activities, emotional well-being, getting along with classmates and academic abilities. The second survey assessed teasing experiences during physical activity. The third survey asked specific situational questions to determine whether the student had been bullied during physical activity and the emotional effect it had. The questions explored experiences such as:

  • Being made fun of when playing sports or exercising.
  • Not being chosen to be on a sports team or other children looking or acting upset when the child was placed on the team.
  • Being called insulting names when playing sports or exercising.

Study results showed a decrease in physical activity of healthy-weight students who are bullied, and a decrease in health-related quality of life for students who were overweight or obese who reported teasing in the first survey.
“Overweight kids who were teased reported poorer functional ability across domains (physical, social, academic and physical),” said Jensen. “If we can help them to have a better perception of their physical and social skills, then physical activity may increase and health-related quality is likely to improve.”
While most schools participate in comprehensive anti-bullying programs, Jensen recommends implementing policies that discourage peer victimization based on physical abilities.
“We hope our study will raise awareness that educators should consider bullying prevention during physical education and free play (recess) when kids may be discouraged from being physically active because of teasing experiences,” Jensen said.

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Using Progesterone For Hot Flashes Shown Safe For Women’s Cardiovascular Health

Treatment with progesterone, a naturally occurring hormone that has been shown to alleviate severe hot flashes and night sweats in post-menopausal women, poses little or no cardiovascular risk, according to a new study by the University of British Columbia and Vancouver Coastal Health.

The findings, published today in PLOS ONE, help to dispel a major impediment to widespread use of progesterone as a treatment for hot flashes and night sweats, said lead author Dr. Jerilynn C. Prior, a professor of endocrinology and the head of Centre for Menstrual Cycle and Ovulation Research.

For decades, women used a combination of synthetic estrogen and progesterone to reduce the frequency and severity of hot flashes and night sweats, as well as to prevent osteoporosis. Use of this so-called “hormone replacement therapy” dropped dramatically after 2002, when a large study revealed that it increased risk of heart disease, breast cancer, strokes and other serious conditions.

To evaluate the cardiovascular risk of using progesterone to alleviate symptoms, Prior and her collaborators recruited 110 healthy Vancouver-area women who had recently reached postmenopause (a year after the final menstruation), giving half of them oral progesterone and the others a placebo for three months.

The team used each woman’s age and changes in blood pressure and cholesterol levels to calculate their 10-year risk of a heart attack and other blood vessel diseases, and found no difference between those taking progesterone and the control group. The study also found no significant difference on most other markers for cardiovascular disease.

“Many women are apprehensive about taking progesterone for hot flashes because of a belief that it carries the same – or even greater – risks than estrogen,” Prior said. “We have already shown that the benefits of progesterone alone have been overlooked. This study demonstrates that progesterone’s risks have been overblown.”

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